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文章速递<i>Aloe vera</i>—Mechanisms of Action, Uses, and Potential Uses in Plastic Surgery and Wound Healing 认领
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作者 Waylon M. Zeng Anamaria Parus +3 位作者 Connor W. Barnes Matthew E. Hiro Martin C. Robson Wyatt G. Payne 《外科学(英文)》 2020年第10期312-328,共17页
<em>Aloe vera</em> has been used for centuries for medicinal purposes. Clinical and experimental evidence indicates usefulness for skin moisturization, promoting wound healing, thermal skin injury, frostbi... <em>Aloe vera</em> has been used for centuries for medicinal purposes. Clinical and experimental evidence indicates usefulness for skin moisturization, promoting wound healing, thermal skin injury, frostbite, and ischemic skin insults. <em>Aloe vera</em> has anti-inflammatory, vasodilatory, antimicrobial, and proliferative actions, which have been investigated in various experimental models and in various in vitro studies. This extensive literature review of the properties and actions of <em>Aloe vera</em> finds substantial evidence for the reported and also likely clinical usefulness for <em>Aloe vera</em> in Plastic Surgery and in wound care and wound healing. Though further clinical investigation is warranted, Aloe vera use may likely be indicated in situations where its effects could positively influence outcomes, such as wound healing, flap vascularity, and inflammatory skin pathologies. 展开更多
关键词 Aloe vera Wound Healing Anti-Inflammatory Prostaglandin Anti-Microbial Anti-Oxidant Angiogenesis
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纳米硒在医药领域中的应用研究进展 认领
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作者 王皓 王玉丽 +4 位作者 孙洁洁 佟瑶 杨阳 高春生 韩翠艳 《国际药学研究杂志》 CAS 北大核心 2020年第5期337-341,346,共6页
硒是一种人体必需的微量元素,可作为硒半胱氨酸结合到硒蛋白中,通过影响某些酶(如谷胱甘肽过氧化物酶)的活性进而发挥各种生理功能,对人体的健康起着至关重要的作用。纳米硒由单质硒聚集而成,具有更高的生物活性和更低的毒性,因此在医... 硒是一种人体必需的微量元素,可作为硒半胱氨酸结合到硒蛋白中,通过影响某些酶(如谷胱甘肽过氧化物酶)的活性进而发挥各种生理功能,对人体的健康起着至关重要的作用。纳米硒由单质硒聚集而成,具有更高的生物活性和更低的毒性,因此在医药领域具有十分广阔的应用前景。本文综述了纳米硒在抗癌、抗炎、抗糖尿病、抗阿尔茨海默病以及降低药物毒性等领域研究进展,并对未来的发展做出了展望,为今后的生物医学应用提供参考。 展开更多
关键词 纳米硒 抗癌 抗炎 抗糖尿病 抗阿尔茨海默病
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迷迭香酸烷基酯的来源及药理活性研究进展 认领
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作者 丁丽敏 赵紫燕 +1 位作者 刘茜茜 刘荣霞 《天然产物研究与开发》 CAS CSCD 北大核心 2020年第3期525-531,共7页
迷迭香酸是一种广泛存在于唇形科植物中的天然水溶性酚酸化合物,由咖啡酸和3,4-二羟基苯基乳酸酯化缩合而成,其具有抗氧化、抗菌、抗炎、抗肿瘤等广泛的药理活性。迷迭香酸衍生物主要是通过对迷迭香酸侧链羧基进行结构改造所得到的一系... 迷迭香酸是一种广泛存在于唇形科植物中的天然水溶性酚酸化合物,由咖啡酸和3,4-二羟基苯基乳酸酯化缩合而成,其具有抗氧化、抗菌、抗炎、抗肿瘤等广泛的药理活性。迷迭香酸衍生物主要是通过对迷迭香酸侧链羧基进行结构改造所得到的一系列化合物,其中具有不同长度烷基链的迷迭香烷基酯,研究最为广泛。迷迭香酸烷基酯体外药理活性研究显示,其具有抗心血管疾病、抗氧化、抗菌、抗炎、抗过敏等药理活性,而且随着酯链长度的不同其活性强度及作用机理存在一定差异。本文主要对迷迭香酸烷基酯的来源及其药理活性进行综述,为迷迭香酸及迷迭香酸烷基酯在临床上的进一步开发利用提供理论依据。 展开更多
关键词 迷迭香酸 迷迭香酸烷基酯 抗心血管疾病 抗氧化 抗炎 抗菌
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Kidney Function in Frequent Users of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) 认领
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作者 Uduagbamen PK Salako BL +2 位作者 Hamzat MA Kadiri S Arogundade FA 《内科学期刊(英文)》 2020年第1期69-82,共14页
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are used for managing painful conditions. They are available as cheap, over-the-counter drugs, and commonly abused. NSAIDs inhibit prostaglandins (PGs) action... Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are used for managing painful conditions. They are available as cheap, over-the-counter drugs, and commonly abused. NSAIDs inhibit prostaglandins (PGs) actions on the kidneys and can cause kidney disease and hypertension, especially when used in excess doses, for prolonged period or in stressed states. Methods: The descriptive study was carried at the Orthopaedic and Family Medicine units of the Federal Medical Centre, Abeokuta. Two hundred respondents participated in the study. One hundred frequent users of NSAIDs (with daily use for ≥ 4 weeks) and age and sex-matched controls with no known risk for kidney disease and had consented were consecutively recruited. Data were entered from history, examination and investigations (urinalysis, serum electrolyte, kidney scan and biopsy). Cases with estimated glomerular filtration rate (eGFR) 2) and dip strip proteinuria ≥ 1+ had kidney biopsy. Statistical analysis was with SPSS 21 software. Student t-test and Chi-square tests were used to compare means and proportions respectively. Pearson’s correlation test was used to determine the strength of association between independent risk factors and kidney dysfunction (KD). Results: Two hundred respondents participated in the study. Fifty one (51) females and Forty nine (49) males were recruited as cases and controls respectively. Thirteen (13) females had KD compared to 9 males, (P = 0.02). The mean age of cases with KD (63.04 yrs ± 4.21) was statistically higher than those without KD (P = 0.01). Majority of the cases were in the working population (30 - 59 yrs). Twenty two (22) frequent NSAIDs users had kidney dysfunction (KD) while six (6%) controls had KD. The proportion of subjects that used herbal medicines was higher in cases with KD than in cases without KD as well as in the controls respectively (P = 0.01). The mean kidney length and cortical thickness were significantly lower in cases with KD than in cases without KD, (P = 0.03) and (P = 0.017) respect 展开更多
关键词 NON-STEROIDAL ANTI-INFLAMMATORY Drugs Glomerular FILTRATION Rate Kidney DYSFUNCTION Body Mass Index Blood Pressure
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The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea 认领
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作者 Daniel Shock Steven Roche +1 位作者 Denis Nagel Merle Olson 《兽医学(英文)》 2020年第3期27-38,共12页
The non-steroidal anti-inflammatory drug meloxicam is commonly used as adjunct therapy for neonatal calf diarrhea to control pain and inflammation. The objective of this study was to compare the pharmacokinetics of me... The non-steroidal anti-inflammatory drug meloxicam is commonly used as adjunct therapy for neonatal calf diarrhea to control pain and inflammation. The objective of this study was to compare the pharmacokinetics of meloxicam in diarrheic pre-ruminant dairy calves dosed either orally or subcutaneously. Twelve pre-ruminant male dairy calves with mild to moderate diarrhea were randomly assigned to receive one of four treatments (three per group): subcutaneous meloxicam (SM, 0.5 mg/kg body weight);an oral bolus meloxicam suspension (OM, 1 mg/kg body weight);an oral meloxicam suspension added to a feeding of oral electrolytes (EM, 1 mg/kg body weight);and an oral meloxicam suspension added to a feeding of milk replacer (MM, 1 mg/kg body weight). The predicted pharmacokinetic parameters for OM, MM, EM, and SM groups were: half-life (56.8 ± 21.7 vs. 136.0 ± 26.6 vs. 85.2 ± 21.7 vs. 36.3 ± 21.7 h), Cmax (4.3 ± 0.4 vs. 3.7 ± 0.4 vs. 3.9 ± 0.4 vs. 2.1 ± 0.4 μg/mL), Tmax (13.3 ± 4.0 vs. 10.7 ± 4.0 vs. 13.3 ± 4.0 vs. 2.7 ± 4.0 h), and AUC0-∞ (383.4 ± 126.8 vs. 877.8 ± 155.3 vs. 457.1 ± 126.8 vs. 126.4 ± 126.8 h * μg/mL). Oral meloxicam, especially MM, had extended elimination phases relative to SM. All meloxicam therapies provided effective therapeutic levels but all oral therapies (1 mg/kg) provided longer durations of activity than injectable meloxicam (0.5 mg/kg). 展开更多
关键词 MELOXICAM DAIRY CALVES Pharmacokinetics DIARRHEA ANTI-INFLAMMATORY
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Tannin-Rich Extract of <i>Chasmanthera dependens</i>Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats 认领
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作者 Tijani S. Abiola Ashimolowo O. Susan Babalola O. Olusegun 《美国分子生物学期刊(英文)》 2020年第1期29-43,共15页
Piroxicam is commonly used as anti-inflammatory and pain relieving drug;however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of di... Piroxicam is commonly used as anti-inflammatory and pain relieving drug;however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of different doses of the tannin-rich extract of Chasmanthera dependens stem (TRECDS) on piroxicam-induced nephrotoxicity in adult male Wistar rats. Thirty-two adult rats were divided into four groups of eight rats per group and treated orally for ten days. Rats in group one received 0.5 ml normal saline (0.9% v/v) and served as normal control group. Rats in group two received 20 mg/kg body weight piroxicam alone. Rats in groups three and four received 20 mg/kg body weight of piroxicam with concomitant administration of 200 and 400 mg/kg body weight of TRECDS. At the expiration of the experiment, rats were sacrificed and the kidney was removed. Renal function was evaluated. The results showed that administration of piroxicam alone caused a significant elevation in the serum concentrations of albumin, creatinine, total protein, urea concentrations and the activity of renal nucleotidase with a reduction in the activity of glucose-6-phosphate dehydrogenase (G6PD) when compared to normal control (p < 0.05). Furthermore, renal tissue from the piroxicam alone treated group revealed a significant decrease in the activities of renal superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase as well as reduced glutathione with concomitant increase in lipid peroxidation and hydrogen peroxide generation. In addition, histological assessment of the renal tissue showed noticeable damage in piroxicam alone treated group. However, concomitant administration of TRECDS showed a dose-dependent reduction in the concentrations and the activity of the kidney markers with significant increase in the activities of G6PD and restores the antioxidant status of the kidney. The results show the nephroprotective potential of TREDS against piroxicam-induced renal damage. 展开更多
关键词 NEPHROTOXICITY Chasmanthera dependens Tannin-Rich Anti-Inflammatory
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Thionization Method of Glycosyl Urea and Carbamide Sugars 认领
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作者 Baktygul Ernazarova Aida Bakirova +3 位作者 Asylkan Dzhumanazarova Zhypargul Abdullaeva Shamirbek Berkmamatov Gulsara Zhusupbaeva 《有机化学国际期刊(英文)》 2020年第3期111-122,共12页
This work is describing a thionization method for glycosyl urea and carbamide of sugars by using the Lawesson’s reagent. It is proposed the method based on the interaction of glycosyl urea and carbamide of sugars wit... This work is describing a thionization method for glycosyl urea and carbamide of sugars by using the Lawesson’s reagent. It is proposed the method based on the interaction of glycosyl urea and carbamide of sugars with the Lawessons reagent at a 1:1 ratio in the presence of a pyridine. As a result, sulfur-containing derivatives of sugar carbamides are obtained with the help of Lawesson’s reagent. Obtained experimental data are indicating the developed new method for thionization of sugar carbamides, which opens up broad possibilities for synthesis of various carbohydrate derivatives of thiourea. Significance of this work is that, thiourea derivatives are promising bactericidal, fungicidal and anti-inflammatory drugs. Therefore, the preparation of thiourea derivatives and the study of their properties remain topical tasks in the field of chemistry. 展开更多
关键词 Glycosyl Urea Glycosyl Thiourea Synthesis Lawesson’s Reagent ANTI-INFLAMMATORY BACTERICIDAL Fungicidal Properties
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连花清瘟方药理研究进展 认领
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作者 叶祖光 张广平 高云航 《中国实验方剂学杂志》 CAS CSCD 北大核心 2020年第22期181-185,共5页
连花清瘟是国家药监局于2004年批准上市的中药新药,目前有胶囊和颗粒剂两个剂型。其功能主治为清瘟解毒,宣肺泄热。用于治疗流行性感冒属热毒袭肺证。该文对其药理作用进行了综述,既往研究显示,连花清瘟具有广谱抗病毒作用,其对流感病... 连花清瘟是国家药监局于2004年批准上市的中药新药,目前有胶囊和颗粒剂两个剂型。其功能主治为清瘟解毒,宣肺泄热。用于治疗流行性感冒属热毒袭肺证。该文对其药理作用进行了综述,既往研究显示,连花清瘟具有广谱抗病毒作用,其对流感病毒、呼吸道合胞病毒、柯萨奇、肠道病毒、单纯疱疹病毒等多种病毒均显示较好的抗病毒活性,而且还对新型冠状肺炎病毒(SARS-CoV-2)和SARS冠状病毒(SARS-CoV)也具有显著抑制作用。研究显示连花清瘟对多种炎证模型显示出明显抗炎效果,其可明显升高免疫功能低下小鼠(氢化可的松致)对2,4-二硝基氟苯诱发的迟发型超敏反应,提高其细胞免疫功能;能够提高免疫功能低下小鼠腹腔巨噬细胞吞噬功能,提高免疫功能低下小鼠血清溶血素抗体水平,提高其体液免疫功能,具有抗炎免疫调节作用。此外其还对呼吸道感染的症状也具有治疗作用,具有显著的退热、止咳、化痰等作用,从而阻断疾病多个病理环节的恶性循环,发挥中医药多靶点、多环节、多途径整体治疗优势。 展开更多
关键词 连花清瘟 抗冠状病毒 抗病毒 抗炎 免疫调节 止咳化痰
虫草素的药理作用及应用前景 认领
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作者 周艳丽 许剑怡 +4 位作者 王宏娟 刘蕊 张景照 赵欣 唐旭东 《中国医药导报》 CAS 2020年第8期39-42,共4页
虫草素是从蛹虫草中分离的一种核苷类抗生素,具有多种生物活性,如抗菌、抗病毒、抗炎、免疫调节、抗肿瘤、降糖降脂和抗衰老等。虫草素对肺部、肝脏、肾脏和胃部等疾病有一定的治疗作用,也可以作为化妆品和保健品原料,还可以用于畜牧业... 虫草素是从蛹虫草中分离的一种核苷类抗生素,具有多种生物活性,如抗菌、抗病毒、抗炎、免疫调节、抗肿瘤、降糖降脂和抗衰老等。虫草素对肺部、肝脏、肾脏和胃部等疾病有一定的治疗作用,也可以作为化妆品和保健品原料,还可以用于畜牧业。随着研究的逐步深入,虫草素的药理作用渐渐被挖掘,其作用机制也愈发清晰。本文总结了近些年来虫草素的药理作用研究及其应用,为后续更加深入地研究虫草素的药理作用和应用奠定了基础。 展开更多
关键词 虫草素 抗炎 抗肿瘤 免疫调节 降糖降脂 抗衰老 应用前景
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“三抗”对乙型肝炎肝衰竭生存者的干预治疗与随访 认领
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作者 莫世燥 王振常 +3 位作者 吕艳杭 吴姗姗 韦琴英 彭丽娜 《中国医药导报》 CAS 2020年第23期102-106,共5页
目的观察抗病毒、抗炎、抗纤维化(“三抗”)对乙型肝炎肝衰竭生存者的疗效。方法选取2016年1月—2018年1月在广西国际壮医医院脾胃肝病科及广西中医药大学第一附属医院肝病中心、广西梧州市藤县中医医院确诊的乙型肝炎肝衰竭生存者240例... 目的观察抗病毒、抗炎、抗纤维化(“三抗”)对乙型肝炎肝衰竭生存者的疗效。方法选取2016年1月—2018年1月在广西国际壮医医院脾胃肝病科及广西中医药大学第一附属医院肝病中心、广西梧州市藤县中医医院确诊的乙型肝炎肝衰竭生存者240例,采用随机数字表法按1∶1∶2原则分为A组(单纯抗病毒治疗,n=60)、B组(抗病毒联合复方益肝灵胶囊,n=60)和C组(“三抗”联合治疗即抗病毒联合复方益肝灵胶囊、柔肝化纤颗粒,n=120)。分析三组治疗前后生物化学应答、肝纤维化指标,HBeAg、HBeAb、HBeAg/Ab转化率及肝组织评分的变化。结果治疗12、24个月后,三组生物化学应答指标谷丙转氨酶(ALT)、总胆红素(TBil)均低于入组时,白蛋白(ALB)、胆碱酯酶(CHE)、凝血酶原(PTA)均高于入组时,且三组间生物化学应答指标比较,差异均有统计学意义(均P<0.05),且C组ALT、TBil低于A、B组,ALB、CHE、PTA高于A、B组(P<0.05);治疗12、24个月后透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(ⅣC)、Ⅲ型前胶原(PCⅢ)均低于入组时,且三组间血清肝纤维化指标比较,差异均有统计学意义(均P<0.05),且C组HA、LN、ⅣC、PCⅢ低于A、B组(P<0.05)。各组治疗后HBeAg/Ab转换低于治疗前(P<0.05),且C组低于A、B组(P<0.05);在度过危险期的56例患者中C组和A、B组治疗前肝组织学评分比较,差异无统计学意义(P>0.05),治疗后的炎症和肝纤维化SSS总分均低于治疗前,且C组低于A、B组(P<0.05)。结论“三抗”联合治疗乙型肝炎肝衰竭生存者能明显改善肝功能、肝脏炎症、肝纤维化及抑制病毒复制,并提高总治疗效率和生存质量。 展开更多
关键词 乙型肝炎肝衰竭 抗病毒 抗炎 抗纤维化
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秋水仙碱抗炎、抗纤维化及抗肿瘤的研究进展 认领
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作者 韦秋琴 张祖隆 《中国现代医学杂志》 CAS 2020年第4期76-81,共6页
秋水仙碱是研究最早的一种生物碱,具有广泛的生物学作用,在临床应用已有200多年历史,具有抗炎、抗纤维化及抗肿瘤等作用,此外临床上还用于治疗白塞病、家族性地中海热等疾病。该文通过相关文献复习,对秋水仙碱的作用机制及其在不同疾病... 秋水仙碱是研究最早的一种生物碱,具有广泛的生物学作用,在临床应用已有200多年历史,具有抗炎、抗纤维化及抗肿瘤等作用,此外临床上还用于治疗白塞病、家族性地中海热等疾病。该文通过相关文献复习,对秋水仙碱的作用机制及其在不同疾病中的疗效作一综述。 展开更多
关键词 秋水仙碱 抗炎 抗纤维化 抗肿瘤 白塞病
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Study on Pharmacological Effects of Calycosin in Astragali Radix 认领
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作者 Yu ZHANG Tong ZHANG +4 位作者 Shinong WANG Yannan LI Hui XUE Wenbo ZUO Chenghao JIN 《药用植物研究:英文版》 2020年第2期38-40,43共4页
Calycosin is an important isoflavone compound in traditional Chinese medicine Astragali Radix.It not only has remarkable anti-oxidation,anti-inflammatory and anti-tumor functions,but also has the characteristics of sm... Calycosin is an important isoflavone compound in traditional Chinese medicine Astragali Radix.It not only has remarkable anti-oxidation,anti-inflammatory and anti-tumor functions,but also has the characteristics of small adverse reactions and low toxicity,so it has attracted wide attention of scholars and researchers.This paper reviewed the pharmacological effects and mechanisms of calycosin in recent years,in the hope of providing a theoretical basis for its clinical application. 展开更多
关键词 CALYCOSIN PHARMACOLOGICAL EFFECT ANTI-OXIDATION ANTI-INFLAMMATORY ANTI-TUMOR
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文章速递The Pattern of Eosinophil Count among Nigerians with Frequent Use of the Commonly Available Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) 认领
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作者 P. K. Uduagbamen A. T. Oyelese +4 位作者 A. O. Adebola Yusuf O. F. Salami C. M. Nwinee M. I. Ogunmola O. Ehioghae 《临床医学国际期刊(英文)》 2020年第10期605-617,共13页
<strong>Introduction: </strong>Non-steroidal anti-inflammatory drugs (NSAIDs) use is very common. NSAIDs use could be associated with elevated eosinophil count which could be a class effect or patient-rela... <strong>Introduction: </strong>Non-steroidal anti-inflammatory drugs (NSAIDs) use is very common. NSAIDs use could be associated with elevated eosinophil count which could be a class effect or patient-related. Inflammation could be the link between NSAIDs use and eosinophilia. <strong>Aims: </strong>To compare the pattern of eosinophil count in the peripheral blood of frequent users of NSAIDs and healthy controls. <strong>Methodology: </strong>Two hundred (one hundred frequent users of NSAIDs and 100 healthy controls) participants who had no known risk factor for kidney disease and had given informed consent were recruited. Blood was taken to determine the white cell count and differentials, serum electrolyte and creatinine, and random blood sugar. <strong>Results:</strong> The mean age of NSAIDs users was not significantly different from controls, P = 0.3. The mean eosinophil count was higher in males than females. The incidence of eosinophilia in NSAIDs users was 4%. The mean Eosinophil count of NSAIDs users was insignificantly higher than controls, 164.3 ± 51 6 vs 135. 6 ± 53.4, P = 0.4. The mean platelet count of NSAIDs users was significantly higher compared to controls, P = 0.04. The mean hematocrit of NSAIDs users was significantly lower than the controls, P = 0.02. Propionic acid derivatives were associated with the highest eosinophil count. Eosinophil count was positively related to age and serum creatinine and inversely related to blood glucose, hematocrit and glomerular filtration rate.<strong> Conclusion: </strong>The incidence of eosinophilia was 4%. The eosinophil count was higher in frequent NSAIDs users than occasional and non-users, in males than females and with use propionic acid derivatives compared to other NSAIDs. The Eosinophil count was positively related to age and platelet count. Being commoner in inflammatory states, the tissue destruction associated with elevated EC can be avoided by the prevention and prompt treatment of inflammatory conditions. 展开更多
关键词 Eosinophilia Kidney Function Non-Steroidal Anti-Inflammatory Drugs Hematocrit Platelet Count Propionic Acid
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文章速递<i>In-Silico</i>Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders 认领
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作者 Vinayak Agarwal Shriya Agarwal +4 位作者 Ramneek Kaur Pranav Pancham Harleen Kaur Siddhi Bhardwaj Manisha Singh 《生物材料与纳米技术(英文)》 2020年第4期279-303,共25页
<strong>Background: </strong>Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also bee... <strong>Background: </strong>Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. <strong>Objective: </strong>The current study is aimed at the <em>in-silico</em> validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. <strong>Methods:</strong> A successful <em>in-silico</em> validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis.<strong> Results & Conclusion:</strong> The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of <span style="white-space:nowrap;">&#8722;</span>17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation. 展开更多
关键词 Antioxidant Anti-Inflammatory Polymeric Nanoparticles Release Kinetics Box Behnken Design Molecular Docking Particle Size Analysis
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文章速递白藜芦醇抗动脉粥样硬化研究进展 认领
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作者 康秉涛 郭蒙 +5 位作者 孙晓莹 田姝薇 李奕衡 靳洁 贾札伊 曹慧玲 《陕西医学杂志》 CAS 北大核心 2020年第11期1527-1530,共4页
心脑血管疾病为全球人类首要死因,动脉粥样硬化(As)是其主要病理基础。As发病机制复杂,与高血脂、高血糖、炎症、内皮损伤等密切相关。白藜芦醇(Res)是多酚类中药单体,具有良好的抗As活性,长期大量使用副作用较小。现综述Res的理化性质... 心脑血管疾病为全球人类首要死因,动脉粥样硬化(As)是其主要病理基础。As发病机制复杂,与高血脂、高血糖、炎症、内皮损伤等密切相关。白藜芦醇(Res)是多酚类中药单体,具有良好的抗As活性,长期大量使用副作用较小。现综述Res的理化性质、提取、合成方法,重点介绍了Res通过改善血脂、抑制炎症、抗氧化、抑制血小板凝聚、降糖等途径改善As的作用,以期为Res的临床应用提供参考。 展开更多
关键词 白藜芦醇 抗动脉粥样硬化 降脂 抗炎 抗氧化
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海菖蒲黄酮FEA对LPS诱导RAW264.7细胞炎症反应的改善作用研究 认领
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作者 朱慧颖 周婉茹 张朝辉 《中国海洋药物》 CAS CSCD 2020年第4期51-55,共5页
目的研究海菖蒲黄酮FEA(Enhalus acoroides flavonoids,FEA)对LPS刺激RAW264.7细胞引起的炎症反应的改善作用。方法用1µg/mL的LPS刺激RAW264.7细胞6 h后,用含有不同浓度的海菖蒲黄酮FEA作用RAW264.7细胞20 h,采用ELISA方法测定RAW2... 目的研究海菖蒲黄酮FEA(Enhalus acoroides flavonoids,FEA)对LPS刺激RAW264.7细胞引起的炎症反应的改善作用。方法用1µg/mL的LPS刺激RAW264.7细胞6 h后,用含有不同浓度的海菖蒲黄酮FEA作用RAW264.7细胞20 h,采用ELISA方法测定RAW264.7细胞分泌的NO、TNF-α、IL-1β和IL-6的含量,采用western-blot方法检测NF-ĸB信号通路中IĸBα、P-IĸBα、p65、P-p65的蛋白表达含量。结果海菖蒲黄酮FEA可以抑制由LPS刺激RAW264.7细胞引起的NO、TNF-α、IL-1β和IL-6细胞因子的分泌,减少磷酸化蛋白IĸBα和p65的表达量。结论海菖蒲黄酮FEA可以减少细胞炎症因子的产生和抑制NF-ĸB信号通路的活化来改善炎症作用。 展开更多
关键词 海菖蒲黄酮FEA 抗炎症 炎症因子 NF-ĸB信号通路
An association between mitochondria and microglia effector function: what do we think we know? 认领
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作者 Gaylia Jean Harry Gabrielle Childers +1 位作者 Sahana Giridharan Irisyunuel Lopez Hernandes 《神经免疫与神经炎症:英文版》 2020年第2期150-165,共16页
While resident innate immune cells of the central nervous system, the microglia, represent a cell population unique in origin, microenvironment, and longevity, they assume many properties displayed by peripheral macro... While resident innate immune cells of the central nervous system, the microglia, represent a cell population unique in origin, microenvironment, and longevity, they assume many properties displayed by peripheral macrophages. One prominent shared property is the ability to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS) upon activation by the pro-inflammatory stimuli lipopolysaccharide. This shift serves to meet specific cellular demands and allows for cell survival, similar to the Warburg effect demonstrated in cancer cells. In contrast, normal surveillance phenotype or stimulation to a non-proinflammatory phenotype relies primarily on OXPHOS and fatty acid oxidation. Thus, mitochondria appear to function as a pivotal signaling platform linking energy metabolism and macrophage polarization upon activation. These unique shifts in cell bioenergetics in response to different stimuli are essential for proper effector responses at sites of infection, inflammation, or injury. Here, we present a summary of recent developments as to how these dynamics characterized in peripheral macrophages are displayed in microglia. The new insights provided by an increased understanding of metabolic reprogramming in macrophages may allow for translation to the central nervous system and a better understanding of microglia heterogeneity, regulation, and function. 展开更多
关键词 Mitochondria bioenergetics INFLAMMASOME MICROGLIA PRO-INFLAMMATORY anti-inflammatory polarization
悬灸早期介入对急性面瘫血清炎性因子的影响 认领
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作者 李德华 李季 +1 位作者 叶小琪 彭倩 《世界中医药》 CAS 2020年第14期2150-2154,共5页
目的:探究悬灸早期介入对急性期面瘫(BP)的抗炎效果,为悬灸急性期介入治疗面瘫提供理论依据。方法:选取2016年3月至2019年3月成都中医药大学附属医院收治的BP患者132例作为研究对象,按照治疗方法的不同分为悬灸组(n=38)、激素组(n=46)... 目的:探究悬灸早期介入对急性期面瘫(BP)的抗炎效果,为悬灸急性期介入治疗面瘫提供理论依据。方法:选取2016年3月至2019年3月成都中医药大学附属医院收治的BP患者132例作为研究对象,按照治疗方法的不同分为悬灸组(n=38)、激素组(n=46)和悬灸加激素组(n=48);同时随机抽取体检中心体检结果无特殊异常者作为正常人群(n=126)。将正常人群同急性期BP患者相关血清炎性因子比较,观察BP患者血清炎性因子有无改变;采用随机对照研究,将急性期BP患者132例分为悬灸组、激素组、悬灸加激素组,均治疗2周,比较患者治疗前后血清炎性因子水平,并同时采用House-Brackmann(H-B)整体评分量表进行疗效评价,观察组间差异。结果:与正常人群比较,急性期BP患者血清相关炎性因子均呈升高趋势,组间比较差异有统计学意义(P<0.05);治疗2周后,3组BP患者血清WBC、NEUT、PLT、TNF、NLR和H-B整体评分与治疗前比较,差异均有统计学意义(P<0.05);治疗后3组间比较,WBC、NEUT、LC差异有统计学意义(P<0.05),其他指标和H-B整体评分3组间比较,差异无统计学意义(P>0.05)。结论:和正常人比较,急性期BP患者血清相关炎性因子呈增高趋势;3种方法均能在一定程度上降低急性期BP患者相关血清炎性因子水平,3种方法疗效差异无统计学意义,悬灸可作为激素的一种替代和补充。 展开更多
关键词 面瘫 贝尔氏麻痹 急性期 悬灸 激素 抗炎 血清炎性因子 疗效评价
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姜黄素类似物A13的抗炎活性研究 认领
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作者 俞聪聪 孔敏 +2 位作者 吴凌智 吕扬歌 沈斌 《中国现代医生》 2020年第25期37-41,F0003,共6页
目的针对本课题组合成的姜黄素类似物A13,研究其抗炎活性。方法采用ELISA检测试剂盒检测脂多糖(LPS)诱导后1 h血清中的肿瘤坏死因子-α(TNF-α)和6 h的白细胞介素-6(IL-6)释放量,观察A13三个剂量(10 mg/kg、15 mg/kg、20 mg/kg)作用后LP... 目的针对本课题组合成的姜黄素类似物A13,研究其抗炎活性。方法采用ELISA检测试剂盒检测脂多糖(LPS)诱导后1 h血清中的肿瘤坏死因子-α(TNF-α)和6 h的白细胞介素-6(IL-6)释放量,观察A13三个剂量(10 mg/kg、15 mg/kg、20 mg/kg)作用后LPS诱导下小鼠炎症因子的释放量变化。采用苏木精-伊红染色(Hematoxylin-Eosin staining,HE染色)切片法比较空白对照Control组、LPS、LPS+A13三组小鼠肝脏和肺脏组织损伤情况。结果LPS组小鼠血清中的TNF-α和IL-6较空白对照Control组均明显升高,差异有统计学意义(P<0.05),LPS诱导下小鼠急性炎症模型造模成功;LPS+A13三个剂量组的炎症因子TNF-α、IL-6释放量均较LPS组降低,分别抑制了45.8%、62.7%、73.1%和20.0%、26.4%、34.7%,差异有统计学意义(P<0.05);与空白对照Control组比较,LPS+A13三个剂量组TNF-α、IL-6释放量均有升高,差异有统计学意义(P<0.05)。A13三个剂量组间两两比较,TNF-α因子差异均有统计学意义(P<0.05);IL-6因子的10 mg/kg与20 mg/kg组比较,差异均有统计学意义(P<0.05);IL-6因子的10 mg/kg与15 mg/kg、15 mg/kg与20 mg/kg组相互比较,差异无统计学意义(P>0.05)。HE染色结果显示A13三个剂量组均肺泡扩张不明显,肺泡腔内渗出物被吸收,肝脏组织结构破坏不明显,肺、肝脏组织结构基本恢复,接近于正常组织结构。结论姜黄素类似物A13能明显抑制LPS诱导的炎症因子TNF-α和IL-6的释放,可改善LPS诱导的肺和肝脏损伤,具有较强抗炎活性。 展开更多
关键词 脂多糖 姜黄素类似物 抗炎 炎症因子
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大蒜素对脂多糖诱导腹腔巨噬细胞炎症反应的抑制作用及机制 认领
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作者 李鸿洋 李敬双 +1 位作者 高泉颀 于洋 《食品工业科技》 CAS 北大核心 2020年第18期308-313,323,共7页
目的:探讨大蒜素对脂多糖(LPS)诱导小鼠腹腔巨噬细胞炎症反应的抑制作用及机制。方法:建立LPS诱导小鼠腹腔巨噬细胞炎症反应细胞模型,并用地塞米松和不同浓度大蒜素处理,MTT法检测细胞活力,中性红吞噬实验检测吞噬能力,Griess法检测一... 目的:探讨大蒜素对脂多糖(LPS)诱导小鼠腹腔巨噬细胞炎症反应的抑制作用及机制。方法:建立LPS诱导小鼠腹腔巨噬细胞炎症反应细胞模型,并用地塞米松和不同浓度大蒜素处理,MTT法检测细胞活力,中性红吞噬实验检测吞噬能力,Griess法检测一氧化氮(NO)及ELISA法检测COX-2酶活性和IL-6的分泌,qPCR检测环氧合酶2(COX-2)、一氧化氮合酶(iNOS)和IL-6的mRNA表达水平,Western Blot检测COX-2、iNOS和IL-6的蛋白表达以及核转录因子NF-κB p65及其磷酸化产物的相对表达。结果:大蒜素浓度在40~160μg/mL范围内对腹腔巨噬细胞均无细胞毒性;与LPS组比较,大蒜素处理组能促进腹腔巨噬细胞的吞噬能力,能显著(P<0.05)抑制炎症因子COX-2酶活性、NO和IL-6的分泌,能显著(P<0.05)抑制基因COX-2、iNOS和IL-6 mRNA和蛋白的相对表达,并极显著(P<0.01)抑制NF-κB p65信号通路的磷酸化。结论:大蒜素能显著抑制LPS诱导的小鼠腹腔巨噬细胞的炎症反应,其机制可能与抑制NF-κB信号通路激活有关。 展开更多
关键词 大蒜素 脂多糖 腹腔巨噬细胞 抗炎 炎症因子 NF-ΚB信号通路
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