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Bone health in diabetes and prediabetes 预览
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作者 Silvia Costantini Caterina Conte 《世界糖尿病杂志:英文版(电子版)》 2019年第8期421-445,共25页
Bone fragility has been recognized as a complication of diabetes,both type 1 diabetes (T1D) and type 2 diabetes (T2D),whereas the relationship between prediabetes and fracture risk is less clear.Fractures can deeply i... Bone fragility has been recognized as a complication of diabetes,both type 1 diabetes (T1D) and type 2 diabetes (T2D),whereas the relationship between prediabetes and fracture risk is less clear.Fractures can deeply impact a diabetic patient’s quality of life.However,the mechanisms underlying bone fragility in diabetes are complex and have not been fully elucidated.Patients with T1D generally exhibit low bone mineral density (BMD),although the relatively small reduction in BMD does not entirely explain the increase in fracture risk.On the contrary,patients with T2D or prediabetes have normal or even higher BMD as compared with healthy subjects.These observations suggest that factors other than bone mass may influence fracture risk.Some of these factors have been identified,including disease duration,poor glycemic control,presence of diabetes complications,and certain antidiabetic drugs.Nevertheless,currently available tools for the prediction of risk inadequately capture diabetic patients at increased risk of fracture.Aim of this review is to provide a comprehensive overview of bone health and the mechanisms responsible for increased susceptibility to fracture across the spectrum of glycemic status,spanning from insulin resistance to overt forms of diabetes.The management of bone fragility in diabetic patient is also discussed. 展开更多
关键词 BONE FRACTURES TYPE 1 DIABETES TYPE 2 DIABETES PREDIABETES DIABETES complications BONE density HYPOGLYCEMIC agents
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Diabetes empowerment scores among type 2 diabetes mellitus patients and its correlated factors:A cross-sectional study in a primary care setting in Malaysia 预览
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作者 Thew Hui Zhu Ching Siew Mooi Nurainul Hana Shamsuddin 《世界糖尿病杂志:英文版(电子版)》 2019年第7期403-413,共11页
BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type ... BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type 2 diabetes patients in a primary care clinic in Malaysia.METHODS This is a cross sectional study involving 322 patients with type 2 diabetes mellitus(DM)followed up in a primary care clinic.Systematic sampling method was used for patient recruitment.The Diabetes Empowerment Scale(DES)questionnaire was used to measure patient empowerment.It consists of three domains:(1)Managing the psychosocial aspect of diabetes(9 items);(2)Assessing dissatisfaction and readiness to change(9 items);and(3)Setting and achieving diabetes goal(10 items).A score was considered high if it ranged from 100 to 140.Data analysis was performed using SPSS version 25 and multiple linear regressions was used to identify the predictors of total diabetes empowerment scores.RESULTS The median age of the study population was 55 years old.56%were male and the mean duration of diabetes was 4 years.The total median score of the DES was 110[interquartile range(IQR)=10].The median scores of the three subscales were 40 with(IQR=4)for"Managing the psychosocial aspect of diabetes";36 with(IQR=3)for"Assessing dissatisfaction and readiness to change";and 34 with(IQR=5)for"Setting and achieving diabetes goal".According to multiple linear regressions,factors that had significant correlation with higher empowerment scores among type 2 diabetes patients included an above secondary education level(P<0.001),diabetes education exposure(P=0.003),lack of ischemic heart disease(P=0.017),and lower glycated hemoglobin(HbA1c)levels(P<0.001).CONCLUSION Diabetes empowerment scores were high among type 2 diabetes patients in this study population.Predictors for high empowerment scores included above secondary education level,diabetes education exposure,lack of ischemic heart disease status and lower HbA1c. 展开更多
关键词 DIABETES EMPOWERMENT SCORES DIABETES EMPOWERMENT Scale Type 2 DIABETES Primary care MALAYSIA
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A glimpse of endocrine pancreas development from single-cell analyses
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作者 Ce Gao Jinrong Peng 《分子细胞生物学报:英文版》 SCIE CAS CSCD 2019年第6期433-434,共2页
Diabetes is a global public health concern in the 21st century. According to the report in the International Diabetes Federation Diabetes Atlas in 2015, 415 million adults suffer from diabetes globally. Although consi... Diabetes is a global public health concern in the 21st century. According to the report in the International Diabetes Federation Diabetes Atlas in 2015, 415 million adults suffer from diabetes globally. Although considerable progress has made in the treatment of diabetes, such as insulin administration, researchers are still looking for alternative therapeutic approaches, e.g. islet transplantation from cadaveric donors, for its radical cure. However, this approach is limited due to the scarcity of donors and availability of islet cells. 展开更多
关键词 endocrine pancreas DEVELOPMENT SINGLE-CELL ANALYSES International DIABETES FEDERATION DIABETES Atlas
北京市朝阳区糖尿病患者糖尿病管理APP使用现状及影响因素研究
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作者 吴延莉 夏云婷 +5 位作者 李剑虹 申涛 韩晓燕 侯亚楠 李梦 张义成 《中国慢性病预防与控制》 CAS CSCD 北大核心 2019年第5期331-335,共5页
目的了解北京市朝阳区糖尿病患者糖尿病管理APP知晓情况及使用现状,分析其影响因素,为糖尿病管理APP技术开发及推广使用提供依据。方法于2017年11月至2018年1月,在北京市朝阳区2个城市社区和2个农村社区中采用单纯随机抽样方法抽取610名... 目的了解北京市朝阳区糖尿病患者糖尿病管理APP知晓情况及使用现状,分析其影响因素,为糖尿病管理APP技术开发及推广使用提供依据。方法于2017年11月至2018年1月,在北京市朝阳区2个城市社区和2个农村社区中采用单纯随机抽样方法抽取610名2型糖尿病患者,通过面对面问卷调查收集调查对象的一般情况、糖尿病管理APP知晓情况、知晓途径、使用情况,分析糖尿病管理APP不同使用情况的原因。采用SPSS19.0软件进行χ^2检验,糖尿病管理APP知晓及使用的影响因素采用多因素logistic回归进行分析。结果共608名2型糖尿病患者纳入研究,糖尿病管理APP知晓率为8.2%,知晓率随糖尿病患者的年龄增加而降低,城镇高于农村,商业服务人员高于其他职业人群,高中及以上人群高于初中及以下人群,未婚或离婚或丧偶者高于已婚者,差异均有统计学意义(P<0.05,P<0.01)。多因素logistic回归分析显示,18~44岁年龄组糖尿病管理APP知晓情况是60岁及以上年龄组3.106倍(OR=3.106,95%CI:1.059~9.109)。糖尿病管理APP的使用率为2.1%,城镇高于农村,商业服务人员高于其他职业人群,高中及以上人群高于初中及以下人群,差异均有统计学意义(P<0.05)。多因素logistic回归分析显示,从事商业服务的患者糖尿病管理APP使用情况是从事其他劳动者的15.645倍(OR=15.645,95%CI:1.737~137.664)。糖尿病管理APP知晓途径占比从高到低依次为网络或电视、朋友或亲人、医护人员、报纸或杂志及其他,分别占47.8%、43.5%、39.1%、26.1%和4.3%。在知晓糖尿病管理APP的患者中,不使用者、使用者分别占74.0%(37/50)、26.0%(13/50)。13例使用者中8例中途放弃使用(61.5%)。糖尿病管理APP不使用的原因主要为“感觉没有用处”,占54.1%(20/37);使用的原因主要为“能提供糖尿病疾病相关知识”、“能记录血糖值”和“能提供饮食指导”,分别占53.8%(7/13)、53.8%(7/13) 展开更多
关键词 糖尿病 糖尿病管理APP 知晓 使用 影响因素
昆明市城乡老年人糖尿病流行现状的对比分析 预览
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作者 杨舒迪 蔡乐 +2 位作者 马国玉 杨家甜 崔文龙 《昆明医科大学学报》 CAS 2019年第4期41-45,共5页
目的 对比分析昆明市城乡两地60岁及以上老年人糖尿病的流行现状。方法 采用多阶段分层随机抽样方法,抽取昆明市官渡区和宜良县3 225名≥60岁的老年人进行现场问卷与体格检查。结果 昆明市城市老年人糖尿病前期及糖尿病的患病率分别为46... 目的 对比分析昆明市城乡两地60岁及以上老年人糖尿病的流行现状。方法 采用多阶段分层随机抽样方法,抽取昆明市官渡区和宜良县3 225名≥60岁的老年人进行现场问卷与体格检查。结果 昆明市城市老年人糖尿病前期及糖尿病的患病率分别为46.7%和24.6%,农村地区的分别为23.2%和11.1%;城市老年人糖尿病前期和糖尿病的患病率均明显高于农村(P<0.01),且分性别、年龄组和文化程度的患病率也均是城市明显高于农村(P<0.01)。城市老年人糖尿病前期的患病率随着年龄增长逐渐降低(P<0.05)。结论 昆明市老年人糖尿病前期及糖尿病的患病率存在着明显的城乡差异,应根据昆明市城乡两地不同特征老年人群的特点,制定有针对性的糖尿病预防控制措施。 展开更多
关键词 糖尿病 糖尿病前期 患病率 城市 农村 老年人
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Nox4在糖尿病及慢性并发症中的作用研究进展 预览
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作者 于婷 李雷 +1 位作者 许飞 辛青 《医学综述》 2019年第10期2016-2022,2028共8页
随着生活方式的改变和预期寿命的延长,世界范围内糖尿病及其慢性并发症的患病率逐年升高。糖尿病慢性并发症(糖尿病肾病、糖尿病大血管病变、糖尿病心肌病、糖尿病视网膜病变、糖尿病神经病变等)是糖尿病患者致死致残的主要原因。还原... 随着生活方式的改变和预期寿命的延长,世界范围内糖尿病及其慢性并发症的患病率逐年升高。糖尿病慢性并发症(糖尿病肾病、糖尿病大血管病变、糖尿病心肌病、糖尿病视网膜病变、糖尿病神经病变等)是糖尿病患者致死致残的主要原因。还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(Nox4)是催化氧生成活性氧类(ROS)的关键酶,Nox4的活性直接受组织氧分压的调控,由Nox4生成的ROS通过氧化应激在糖尿病及其慢性并发症的发病及进展过程中发挥重要作用。 展开更多
关键词 糖尿病 还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶4 过氧化氢 活性氧自由基 糖尿病慢性并发症
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糖尿病接纳与行动问卷的汉化及信效度检验 预览
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作者 谢婵娟 许湘华 +2 位作者 欧美军 毛婷 谌永毅 《护理研究》 北大核心 2019年第1期37-41,共5页
[目的]翻译并验证糖尿病接纳与行动问卷,为我国糖尿病病人开展接纳与承诺疗法相关研究提供测量工具。[方法]通过跨文化调适形成初始量表;对124例糖尿病病人进行探索性因子分析;从总体随机选取30例病人重测。[结果]问卷结果显示:条目鉴... [目的]翻译并验证糖尿病接纳与行动问卷,为我国糖尿病病人开展接纳与承诺疗法相关研究提供测量工具。[方法]通过跨文化调适形成初始量表;对124例糖尿病病人进行探索性因子分析;从总体随机选取30例病人重测。[结果]问卷结果显示:条目鉴别度检验P<0.001,条目同质性检验相关系数为0.57~0.74;探索性因子分析,只有1个特征根>1的公因子,可解释总变异的43.61%;内部一致性Cronbach′sα系数、分半信度、重测信度分别为0.76、0.73和0.89。[结论]中文版糖尿病接纳与行动问卷具有良好的心理测量学指标,能为我国糖尿病接纳与承诺疗法相关研究提供有效的测评工具。 展开更多
关键词 糖尿病 糖尿病接纳与行动问卷 心理测量学 信度 效度
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糖尿病相关心理痛苦的研究进展 预览
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作者 杨梦莹 王旋 +4 位作者 谢李 张彩虹 李海燕 陈杨 李应 《教育教学论坛》 2019年第22期81-82,共2页
糖尿病相关心理痛苦会在一定程度上影响患者的治疗依从性、自我管理行为和生活质量。本文通过了解国内外糖尿病相关心理痛苦的研究现状,为有效减轻糖尿病相关心理痛苦提供策略,从而提高患者的生活质量。
关键词 糖尿病 糖尿病相关心理痛苦 综述
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糖尿病护理小组在糖尿病患者护理中的应用 预览
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作者 谭红琼 《中国继续医学教育》 2019年第5期181-183,共3页
目的分析糖尿病临床护理中糖尿病护理小组的应用价值。方法2014年5月—2017年12月,于我院收治的糖尿病患者中选取80例,以护理方式为依据,分为两组,对照组患者行常规护理,在此基础上,观察组患者通过糖尿病护理小组接受护理,对比两组患者... 目的分析糖尿病临床护理中糖尿病护理小组的应用价值。方法2014年5月—2017年12月,于我院收治的糖尿病患者中选取80例,以护理方式为依据,分为两组,对照组患者行常规护理,在此基础上,观察组患者通过糖尿病护理小组接受护理,对比两组患者饮食习惯、自理能力、血糖控制效果以及服药依从性等各项临床指标情况与血糖指标波动监测结果。结果与对照组对比,观察组饮食习惯、自理能力、血糖控制效果以及服药依从性等各项临床指标评分更高,MAGE、MODD、MBG各项水平更低,P<0.05。结论糖尿病临床护理中糖尿病护理小组的应用价值显著,有利于提高患者依从性与自理能力,稳定血糖水平。 展开更多
关键词 糖尿病 临床护理 糖尿病护理小组 血糖 常规护理 依从性
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七味白术散合补阳还五汤加减治疗2型糖尿病脾虚湿困证疗效评价 预览
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作者 张绪峰 《糖尿病新世界》 2019年第9期85-86,共2页
目的探讨七味白术散合补阳还五汤加减治疗2型糖尿病脾虚湿困证疗效。方法以随机的方式选取36例在该院进行2型糖尿病脾虚湿困证治疗的患者作为本次调查对比的对象,病例选取时间为2016年3月-2018年9月。根据随机的方式将参与该次调查的患... 目的探讨七味白术散合补阳还五汤加减治疗2型糖尿病脾虚湿困证疗效。方法以随机的方式选取36例在该院进行2型糖尿病脾虚湿困证治疗的患者作为本次调查对比的对象,病例选取时间为2016年3月-2018年9月。根据随机的方式将参与该次调查的患者分为对照组和实验组,每组18例患者。对照组给予患者常规治疗,实验组给予患者七味白术散合补阳还五汤加减治疗。观察对照组和实验组临床治疗效果。结果治疗后对照组中医证候积分高于实验组,空腹血糖高于实验组、餐后2h血糖高于实验组、体质量指数高于实验组,经对比结果证实两组之间的差异有统计学意义(P<0.05)。结论在2型糖尿病脾虚湿困证治疗中,可采取七味白术散合补阳还五汤加减方治疗方式,治疗显著,值得临床应用。 展开更多
关键词 糖尿病 七味白术散 2型糖尿病脾虚湿困证 疗效评价
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糖化血红蛋白检测在妊娠合并糖尿病诊疗中的价值 预览
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作者 程兰 祖木热提·阿布都散力木 +1 位作者 王笑 陈叙(审校) 《国际妇产科学杂志》 CAS 2019年第4期397-401,共5页
妊娠合并糖尿病包括孕前糖尿病(PGDM)和妊娠期糖尿病(GDM),与母儿近远期并发症有关。糖化血红蛋白(HbA1c)可反映近2~3个月血糖水平,近年来用作非妊娠期糖尿病的诊断标准之一。很多学者对不同妊娠时期HbA1c水平能否预测GDM的发生、母儿... 妊娠合并糖尿病包括孕前糖尿病(PGDM)和妊娠期糖尿病(GDM),与母儿近远期并发症有关。糖化血红蛋白(HbA1c)可反映近2~3个月血糖水平,近年来用作非妊娠期糖尿病的诊断标准之一。很多学者对不同妊娠时期HbA1c水平能否预测GDM的发生、母儿不良妊娠结局和母亲产后糖尿病发生风险以及不同种族HbA1c水平差异、HbA1c水平的影响因素等方面进行了大量研究,多数认为HbA1c作为GDM的诊断指标敏感度不高,可能增加漏诊率,但其单独或与更多指标联合是筛查和诊断GDM的有力补充,可以减少口服葡萄糖耐量试验(OGTT)的检测。孕期不同时点的HbA1c水平均可能与妊娠结局有关,而产前HbA1c水平对识别可能进展为2型糖尿病的高危GDM孕妇也有一定的价值。不过,对HbA1c的截断值、包含HbA1c的不同筛查诊断策略意见尚不统一,仍需更多的研究进一步明确。 展开更多
关键词 糖尿病 妊娠 血红蛋白A 糖基化 葡糖耐量试验 糖尿病 预测
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Diabetic neuropathy research: from mouse models to targets for treatment 预览
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作者 Vuong M. Pham Shinji Matsumura +2 位作者 Tayo Katano Nobuo Funatsu Seiji Ito 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1870-1879,共10页
Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the deve... Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment. 展开更多
关键词 brain derived NEUROTROPHIC FACTOR DIABETES extrinsic FACTORS NERVE growth FACTOR NERVE regeneration NEUROTROPHIC FACTORS NON-OBESE type 2 DIABETES phosphatase and tensin homolog stem cell streptozotocin
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腹膜透析患者经透析液吸收葡萄糖的能量不预测新发糖尿病或糖耐量受损 预览
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作者 付纲 王玉柱 董捷 《中国血液净化》 CSCD 2019年第5期295-299,共5页
目的确定腹膜透析患者经透析液吸收葡萄糖的能量和新发糖尿病或糖耐量受损(new-onset diabetes/impaired glucose tolerance,NODI)的关系。方法回顾性单中心的队列研究,入选所有2007年8月~2011年8月的非糖尿病腹膜透析患者。记录基线人... 目的确定腹膜透析患者经透析液吸收葡萄糖的能量和新发糖尿病或糖耐量受损(new-onset diabetes/impaired glucose tolerance,NODI)的关系。方法回顾性单中心的队列研究,入选所有2007年8月~2011年8月的非糖尿病腹膜透析患者。记录基线人口学资料,基线及随后每3个月的生化参数、透析处方、透析充分性和营养参数,计算经透析液吸收的葡萄糖和能量,建立基线和时间平均变量的多元Cox回归模型来预测NODI的危险因素。结果共入选256名腹膜透析患者,平均随访32.4(12.9~60.8)个月,有25(4.1%)例患者诊断为新发糖尿病,7(1.1%)例患者诊断为糖耐量受损。时间平均的经透析液吸收葡萄糖的能量为(310.9±120.1)kcal/天。多变量Cox回归分析发现,经透析液吸收葡萄糖的能量(HR=1.000,95%CI 0.996~1.005,P=0.883)并不预测NODI的风险,时间平均的体质量指数(HR=1.194,95%CI 1.067~1.335,P=0.002)是NODI的独立危险因素。结论腹膜透析患者经透析液吸收葡萄糖的能量并不预测NODI的发生。 展开更多
关键词 腹膜透析 糖尿病 糖耐量受损 新发糖尿病
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Do we need to screen every patient in intensive care unit for diabetes in community with high prevalence of diabetes? 预览
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作者 Taru Dutt Rahul Kashyap Salim Surani 《世界糖尿病杂志:英文版(电子版)》 2019年第3期137-139,共3页
Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of e... Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of easily accessibility knowledge about its early signs and symptoms and rapid diagnostic modalities. Critically ill patients with undiagnosed DM are likely to have an increased mortality as compared to intensive care unit (ICU) patients with diagnosed DM. DM may have adverse effect on ICU patients causing organ failure and complications. Early Screening of patients at the risk of developing disease may prevent long term complications. Early screening and management may be beneficial as controlled DM patients have similar morbidity as non DM patients in ICU. An intense glycaemic and blood pressure control improves retinopathy and albuminuria, but may not affect the macrovascular outcomes. 展开更多
关键词 DIABETES MELLITUS INTENSIVE care unit MICROVASCULAR MACROVASCULAR DIABETES screening
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Risk factors in patients with type 2 diabetes in Bengaluru: A retrospective study 预览
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作者 Jagadeesha Aravinda 《世界糖尿病杂志:英文版(电子版)》 2019年第4期241-248,共8页
BACKGROUND Risk factors such as hereditary, ecological, and metabolic are interrelated and contribute to the development of type 2 diabetes mellitus. Family history (FH) of diabetes mellitus, age, obesity, and physica... BACKGROUND Risk factors such as hereditary, ecological, and metabolic are interrelated and contribute to the development of type 2 diabetes mellitus. Family history (FH) of diabetes mellitus, age, obesity, and physical inactivity are some of the risk factors for the development of type 2 diabetes. AIM To study various aetiological determinants and risk factors for type 2 diabetes in Bangalore, India. This retrospective study examined questionnaire from patients attending the Diabetes Clinic. METHODS Data on various parameters were obtained through a questionnaire from 533 patients on the first visit to the diabetes clinic. Data regarding various aetiological determinants and risk factors viz.: Genetic risk factor and few modifiable risk factors were collected. Chi-squared test was used for statistical analysis. RESULTS A higher incidence of type 2 diabetes in males and younger population was observed in Bangalore, India. Obesity and FH were significant risk factors for not only type 2 diabetes but also early onset of diabetes. In addition, maternal history of type 2 diabetes and consanguinity increased incidence of early onset type 2 diabetes. CONCLUSION Risk factors such as obesity and FH (maternal history of type 2 diabetes) and consanguinity may play an important role in screening of family members of type 2 diabetes patients which may lead to early intervention and reduced risk of subsequent complications. Moreover, susceptible population can be counselled for the management of the type 2 diabetes including periodic investigation of blood glucose levels and lifestyle changes. 展开更多
关键词 Type 2 diabetess MELLITUS Young ONSET DIABETES Family history CONSANGUINITY DIABETES risk factors OBESITY
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张玉琴教授治疗消渴病合并不寐临证经验 预览
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作者 孙欣 张玉琴 《中国当代医药》 2019年第12期138-140,共3页
失眠是糖尿病常见的并发症之一,对糖尿病患者日间社会功能造成严重影响。张玉琴教授从事消渴及其并发症的治疗已四十余载,熟读中医古典理论并结合临床实践,将消渴病合并不寐之病机主要归为气阴两虚兼瘀,热扰心神,心肾不交所致失眠。治... 失眠是糖尿病常见的并发症之一,对糖尿病患者日间社会功能造成严重影响。张玉琴教授从事消渴及其并发症的治疗已四十余载,熟读中医古典理论并结合临床实践,将消渴病合并不寐之病机主要归为气阴两虚兼瘀,热扰心神,心肾不交所致失眠。治疗上张玉琴教授根据患者的不同兼症辨证施治,四诊合参,灵活加减化裁,取得较好的临床疗效。 展开更多
关键词 失眠 糖尿病 消渴病合并不寐
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Prevalence and associated factors of hospitalization for dysglycemia among elderly type 2 diabetes patients: A nationwide study 预览
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作者 Wisit Kaewput Charat Thongprayoon +5 位作者 Narittaya Varothai Anupong Sirirungreung Ram Rangsin Tarun Bathini Michael A Mao Wisit Cheungpasitporn 《世界糖尿病杂志:英文版(电子版)》 2019年第3期212-223,共12页
BACKGROUND The prevalence of older individuals with type 2 diabetes mellitus (T2DM) is increasing due to the aging population and improved medical care. These patients are very susceptible to disease and treatment-rel... BACKGROUND The prevalence of older individuals with type 2 diabetes mellitus (T2DM) is increasing due to the aging population and improved medical care. These patients are very susceptible to disease and treatment-related hospitalizations, resulting in higher health care costs, morbidity, and decreased quality of life. However, data of treatment-related complications, especially dysglycemiarelated hospitalizations, are lacking. AIM To assess the prevalence and associated factors for dysglycemia-related hospitalizations among elderly diabetic patients in Thailand using nationwide patient sample. METHODS T2DM patients aged ≥ 65 years who received medical care at public hospitals in Thailand in the year 2014 were included. The prevalence of hospitalization due to dysglycemia within one year was examined. Multivariable logistic regression was performed to assess the independent factors associated with hospitalization due to hypoglycemia and hyperglycemia RESULTS A total of 11404 elderly T2DM patients were enrolled in this study. The mean age was 72.9 ± 5.5 years. The prevalence of hospital admissions due to diabetic ketoacidosis, hyperosmolar hyperglycemic state, hyperglycemic dehydration syndrome, and hypoglycemia among elderly T2DM patients in the year 2014 was 0.1%, 0.1%, 1.7% and 3.1%, respectively. Increased hospitalization due to hypoglycemia was associated with older age, female sex, had hypertension, dementia, lower body mass index, elevated hemoglobin A1C (HbA1C), decreased kidney function, insulin use. Increased hospitalization due to hyperglycemia was associated with dementia, depression, lower body mass index, elevated HbA1C, and insulin use. CONCLUSION The prevalence of dysglycemia-related hospitalization in elderly T2DM patients in Thailand was 4.9%. Close monitoring of blood glucose should be provided in high-risk patients for prevention and early detection for these complications. 展开更多
关键词 Type 2 DIABETES mellitus HOSPITALIZATION DIABETES in elderly DYSGLYCEMIA HYPOGLYCEMIA HYPERGLYCEMIA
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40岁~59岁男性人群血脂异常与高血压、糖尿病的关系
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作者 邱毅 刘毅菊 +3 位作者 郑祖峰 季晓东 倪雪寅 叶欣欣 《中国卫生检验杂志》 CAS 2019年第14期1738-1741,共4页
目的探讨40岁~59岁男性人群血脂异常与高血压、糖尿病的关系。方法回顾性选取2014年-2017年在本院健康体检者3 400例,进行相关资料统计分析。结果 40岁~59岁男性人群血脂异常患病率为41. 7%,其中总胆固醇、甘油三酯、低密度脂蛋白胆固... 目的探讨40岁~59岁男性人群血脂异常与高血压、糖尿病的关系。方法回顾性选取2014年-2017年在本院健康体检者3 400例,进行相关资料统计分析。结果 40岁~59岁男性人群血脂异常患病率为41. 7%,其中总胆固醇、甘油三酯、低密度脂蛋白胆固醇及非高密度脂蛋白胆固醇升高率分别为17. 4%、25. 5%、11. 4%和14. 2%,高密度脂蛋白胆固降低率为9. 4%,同时3种疾病患病率(糖尿病16. 8%、高血压9. 4%、糖尿病合并高血压4. 9%)均高于血脂正常者(P <0. 01);多因素Logistic回归结果显示,血脂异常男性人群,3种疾病患病风险是正常人群的1. 336倍~3. 720倍;高密度脂蛋白胆固醇减少1个标准差或其他类型血脂每增加1个标准差,3种疾病患病风险增加在28. 7%~65. 3%。结论 40岁~59岁男性人群血脂异常与3种疾病关系密切,已成为公共卫生问题,应予以血脂异常及3种疾病的综合防治。 展开更多
关键词 血脂异常 糖尿病 高血压 糖尿病合并高血压
Vascular endothelial dysfunction, cardiomyopathy a major mediator in diabetic cardiomyopathy
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作者 Maura Knapp Xin Tu Rongxue Wu 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第1期1-8,共8页
Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic pa... Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients.While ischemic events are commonly observed in diabetic patients,the risk for developing heart failure is also increased,independent of the severity of coronary artery disease and hypertension.This diabetes-associated clinical entity is considered a distinct disease process referred to as "diabetic cardiomyopathy".However,it is not clear how diabetes promotes cardiac dysfunction.Vascular endothelial dysfunction is thought to be one of the key risk factors.The impact of diabetes on the endothelium involves several alterations,including hyperglycemia,fatty acid oxidation,reduced nitric oxide (NO),oxidative stress,inflammatory activation,and altered barrier function. The current review provides an update on mechanisms that specifically target endothelial dysfunction,which may lead to diabetic cardiomyopathy. 展开更多
关键词 CARDIOMYOPATHY diabetes DIABETIC CARDIOVASCULAR COMPLICATIONS ENDOTHELIUM vascular heart failure metabolism
个体化健康教育对糖尿病患者医嘱遵从性的影响
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作者 向静 蓝梅 《中华医学教育探索杂志》 2019年第4期424-426,共3页
目的探讨个体化健康教育在糖尿病患者中的应用效果,以及对患者医嘱遵从性的影响。方法102例我院收治的糖尿病患者按1∶1随机分为对照组(n=51)和观察组(n=51),分别采用常规降糖治疗和配合护理个体化健康教育的降糖治疗。通过健康教育调... 目的探讨个体化健康教育在糖尿病患者中的应用效果,以及对患者医嘱遵从性的影响。方法102例我院收治的糖尿病患者按1∶1随机分为对照组(n=51)和观察组(n=51),分别采用常规降糖治疗和配合护理个体化健康教育的降糖治疗。通过健康教育调查评估患者的医嘱遵从情况。采用SPSS 13.0进行卡方检验。结果评估治疗依从(98.04% vs. 80.39%)、戒烟限酒(92.16% vs. 72.55%)、合理饮食(86.27% vs. 66.67%)、运动锻炼(80.39% vs. 58.82%)、血糖监测(84.31% vs. 62.75%)五方面指标,观察组患者的医嘱遵从率均明显高于对照组(P<0.05)。结论个体化健康教育在糖尿病患者中的应用能够有效提高患者对医嘱的遵从性,值得推广使用。 展开更多
关键词 个体化健康教育 糖尿病 医嘱遵从性
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