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Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions 预览
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作者 Lan Huong Nguyen William Ong +3 位作者 Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期739-747,共9页
MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which ... MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. 展开更多
关键词 central nervous system electrospinning gene SILENCING GLIA hydrogel MYELINATION nanofibers oligodendroglial POLYCAPROLACTONE spinal cord injury
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甲基丙烯酰胺基明胶水凝胶研究进展 预览
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作者 王毅虎 曹霄峰 +3 位作者 张兵 王佳宁 张炜杰 郭燕川 《影像科学与光化学》 CAS 2020年第1期22-26,共5页
甲基丙烯酰胺基明胶(GelMA)水凝胶的制备及其在生物医学领域的应用是最近十几年的研究热点。GelMA水凝胶因其独特的光致交联特性,可以加工成不同形貌的水凝胶支架材料,同时,因其具有可控的力学性能、降解性能,以及优秀的生物相容性,已... 甲基丙烯酰胺基明胶(GelMA)水凝胶的制备及其在生物医学领域的应用是最近十几年的研究热点。GelMA水凝胶因其独特的光致交联特性,可以加工成不同形貌的水凝胶支架材料,同时,因其具有可控的力学性能、降解性能,以及优秀的生物相容性,已成为具有广泛应用前景的生物高分子聚合物材料。本文主要介绍了GelMA水凝胶在止血材料、创伤敷料、组织工程支架、药物控释、骨缺损修复等领域的研究进展。 展开更多
关键词 甲基丙烯酰胺基明胶 水凝胶 生物医用材料 组织工程
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Analysis about the Behavior and Modeling of pH-Sensitive Hydrogels with Different Ratios of Chitosan and Polyvinylpyrrolidone 预览
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作者 Daniela Ribeiro Gabriel Yuto Silvia Lenyra Meirelles Campos Titotto 《材料科学与化学工程(英文)》 2019年第8期64-76,共13页
Smart material can be defined as a material that can dock or convert energy between physical domains or as a material that can generate a response, in their characteristics, properties or geometries, when submitted to... Smart material can be defined as a material that can dock or convert energy between physical domains or as a material that can generate a response, in their characteristics, properties or geometries, when submitted to an external stimulus, for example, to heat, water presence, light, etc. In this paper, the second definition will be approached. Hydrogels are crosslinked materials that can absorb a big amount of water. They generally can be considered as smart materials once they exhibit sensibility to external stimuli like to pH variation, as will be approached in this paper. Thus, chitosan/polyvinylpyrrolidone hydrogels of three different ratios between these two polymers (1:1, 7:3 and 3:7) were synthesized and putted in aqueous solution with different pHs. The pH was adjusted adding drops of NaOH and HCl, slowly. After the collection of results and in order to understand the phenomena in a visual way, models of the molecules were also elaborated using the Avogadro software. Therefore, it was possible to realize that the greater the ratio of chitosan in the hydrogel, the greater its sensitivity to pH. Such characteristic is associated with the amino (-NH2) groups in it structure, which are capable of protonating and deprotonating (depending of the pH), generating charges under the chemical structure of the material, which will expand its volume in order to minimize the repulsion between charges. In addition, it was also noted that the hydrogel expansion is inversely proportional to the pH increase. By practical tests, it was possible to conclude that chitosan/PVP hydrogel with ratio 7:3 is the most interesting once it presented a greater quantity of chitosan in its composition, what implied in more rigidity than the others and greater ease of handling, resulting in more reliable results. This hydrogel also showed higher sensitivity to pH. 展开更多
关键词 CHITOSAN HYDROGEL SMART MATERIAL pH Sensitivity POLYVINYLPYRROLIDONE Modeling
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Preparation of Photo-thermal Cellulose Nanocrystal-based Hydrogel 预览
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作者 ZiHe Guo Tao Ma ShiYu Fu 《造纸与生物质材料:英文版》 2019年第2期32-39,共8页
Cellulose nanocrystal(CNC)prepared by hydrolysis of cotton linters with sulfuric acid was used to react with chloroauric acid to manufacture a gold nanoparticle/CNC composite.The composite was then graft-copolymerized... Cellulose nanocrystal(CNC)prepared by hydrolysis of cotton linters with sulfuric acid was used to react with chloroauric acid to manufacture a gold nanoparticle/CNC composite.The composite was then graft-copolymerized with N-isopropylacrylamide to obtain a photo-thermal ultrafine gold nanoparticles/CNC-based hydrogel.The hydrogel was studied by performing scanning electron microscopy,and it was found that the prepared hydrogel had a network structure.The temperature of the hydrogel increased from 25℃to 39℃and its volume decreased by 30%when it was exposed to visible light(400~750 nm)for 1 h.The experiment results indicated that the prepared photo-thermal CNC-based hydrogel has thermal responsiveness and photo-thermal properties. 展开更多
关键词 CNC GOLD nanoparticle/CNC composite CNC-based HYDROGEL photo-thermal HYDROGEL
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Hydrogel Fibre: Future Material of Interest for Biomedical Applications 预览
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作者 A. K. M. Ayatullah Hosne Asif Mahbubur Rahman +2 位作者 Priti Sarker Md. Zayedul Hasan Debasree Paul 《纺织科学与技术(英文)》 2019年第4期92-107,共16页
Exploration on hydrogel fibres concerning about smart based application in the medical sector has stimulated great interests for the last couple of years due to its wide range of purposes that include actuators, artif... Exploration on hydrogel fibres concerning about smart based application in the medical sector has stimulated great interests for the last couple of years due to its wide range of purposes that include actuators, artificial adhesives, transplantable tissue organs, cell scaffolds, cell therapeutics, wound healing, cartilage or bone regeneration. Nevertheless, recently hydrogel fibre based biomaterials have drawn great concentration for use in a wide variety of biomedical applications like the sustained release of drugs. This is due to the fact that, hydrogel fibers are biocompatible and their similarity about physical properties is in relation with natural tissue. This review article prescribes about the application of hydrogels with diversified prospects in tissue engineering, wound care dressings, soft tissue recovery and plastic surgery. As the products of hydrogels are composed with a group of polymeric materials, the hydrophilic network structure makes them competent for holding an immense quantity of water in their three-dimensional polymer network structure. A wide-ranging application of these products in modern industrial and environmental areas has already taken into account to be of prime importance. Inevitably, natural hydrogels right is now gradually replaced by synthetic types due to their larger amount of water absorption capacity, durability alongside with wide ranges of raw chemical resources. 展开更多
关键词 HYDROGEL TISSUE Engineering WOUND DRESSING SOFT TISSUE Recovery Plastic Surgery
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自愈合水凝胶的合成机理及生物医学应用 预览
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作者 李进 赵梓年 +2 位作者 李征征 薛松 郑泽邻 《材料导报》 EI CAS CSCD 北大核心 2019年第19期3328-3335,3346共9页
高分子水凝胶是一种具有极高含水量的软物质,一般由低交联度的聚合物构成。水凝胶结构和性质与人体软组织高度相似,因此水凝胶已被广泛应用于生物医学等领域。自我修复水凝胶是一种可以在受到损伤后,自动恢复其完整性和自身功能的一类... 高分子水凝胶是一种具有极高含水量的软物质,一般由低交联度的聚合物构成。水凝胶结构和性质与人体软组织高度相似,因此水凝胶已被广泛应用于生物医学等领域。自我修复水凝胶是一种可以在受到损伤后,自动恢复其完整性和自身功能的一类新型水凝胶。迄今为止,研究者通过物理或动态化学键合成了多种自愈合水凝胶。物理交联水凝胶是通过多重氢键作用、主-客体相互作用、离子键、金属配位、疏水相互作用和超分子相互作用等合成的。化学交联水凝胶则是通过动态化学键合成的自愈合水凝胶,与物理自愈合水凝胶相比,其内部交联网络连接强度较高,从而导致其具有更快的自愈过程和更高的机械强度。因此,动态化学键,如亚胺键、酰腙键和二硫键已被广泛用于制备自愈合水凝胶。自愈合水凝胶作为一种新型智能材料,在医疗生物领域具有十分广泛的应用前景。然而,大部分水凝胶是响应外部刺激反应的亲水性交联三维体系。在体内,一旦外部机械力或生理侵蚀破坏了水凝胶结构的完整性,水凝胶的功能性就会丧失。因此,在使用过程中水凝胶的结构和功能完整性会受到外部机械力或化学侵蚀的影响,特别是在复杂的体内环境中。为解决这一问题,已经设计开发出的具有内在自愈合能力的自愈合水凝胶可以克服内外环境的破坏性因素。凭借自愈能力,水凝胶在有外界刺激或无外界刺激的情况下修复自身损伤并恢复其原有结构和性能,从而提高水凝胶的可靠性与安全性。与传统水凝胶相比,自愈合水凝胶具有更长的使用寿命和更好的力学性能,使得自愈合水凝胶尤其是在三维细胞培养、组织工程、药物传送等方面具有更广阔的应用前景。由于自愈合水凝胶的研究尚处于起步阶段,目前大多数研究还处于探索寻求新型自愈合水凝胶体系的阶段。本� 展开更多
关键词 水凝胶 自愈性 非共价键 动态共价键 生物医学领域
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A Polysaccharide-based Hydrogel and PLGA Microspheres for Sustained P24 Peptide Delivery: An In vitro and In vivo Study Based on Osteogenic Capability
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作者 CAI Qing QIAO Chunyan +3 位作者 NING Jun DING Xinxin WANG Haoyang ZHOU Yanmin 《高等学校化学研究:英文版》 SCIE CAS CSCD 2019年第5期908-915,共8页
A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S [PO4]KIPKASSVPTELSAISTLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone d... A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S [PO4]KIPKASSVPTELSAISTLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone defects, while a continuous sustained delivery of P24 may lead to a better formation of bone tissue. Based on this issue, we have developed a sustained delivery system incorporating P24-loaded poly(lactide-co-glycolide)(PLGA) microspheres and nano-hydroxyapatite(n-HA) into the composite hydrogel. The P24-contained compound material was characterized with NMR, FTIR and SEM to demonstrate the fomiation of compound structure containing P24, PLGA and n-HA. A continuous drug release of P24 was observed for over 60 d that evidently enhanced the efficiency in promoting the proliferation of MC3T3-E1 cells and the secrete of alkaline phosphatase(ALP) in vitro. Moreover, the osteoinduction eflect of the hydrogel system with P24 peptide niicrospheres was demonstrated in vivo and manifested by the result of immunohistochemistry. This novel injectable composite hydrogel is expected to be applied to improving the bone defect treatment in bone tissue engineering. 展开更多
关键词 BMP-2 derived peptide HYDROGEL PLGA MICROSPHERE OSTEOGENESIS Tissue engineering
水凝胶的制备及其在医药领域的应用 预览
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作者 冼钟铖 李培源 《山东化工》 CAS 2019年第21期57-59,共3页
随着科技的不断进步,水凝胶的制备及其应用在很多领域都取得了重大的突破。水凝胶的物理化学性质,如溶胀性、粘附性、环境敏感性等,与其在许多领域应用上有着非常密切的关系,本文主要就水凝胶的制备以及医药等领域的应用进行论述。
关键词 水凝胶 制备 药学
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甲基丙烯酸接枝纳米纤维素水凝胶的制备及吸附性能研究 预览
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作者 朱俊芳 杨嵘晟 冯树波 《化学研究与应用》 CAS CSCD 北大核心 2019年第2期325-331,共7页
本文通过酸解法制备纳米纤维素(nCE),再利用自由基聚合法将甲基丙烯酸(MAA)接枝到纳米纤维素上,得到含有多孔结构的纤维素基水凝胶,并以制备的水凝胶作为吸附剂处理染料废水。用傅里叶变换红外光谱仪(FTIR)、和扫描电镜(SEM)技术对其进... 本文通过酸解法制备纳米纤维素(nCE),再利用自由基聚合法将甲基丙烯酸(MAA)接枝到纳米纤维素上,得到含有多孔结构的纤维素基水凝胶,并以制备的水凝胶作为吸附剂处理染料废水。用傅里叶变换红外光谱仪(FTIR)、和扫描电镜(SEM)技术对其进行了表征。讨论了吸附时间、pH、染料初始浓度、吸附剂用量对染料去除率的影响,优化了吸附条件。并对吸附机理进行了探讨,吸附动力学符合准二级动力学模型,平衡吸附等温线与Langmuir吸附等温方程拟合。通过对吸附等温线的拟合,计算得到了吸附剂对亚甲基蓝(MB)的最大吸附量为1250.00mg·g^-1。 展开更多
关键词 纳米纤维素 甲基丙烯酸 水凝胶 吸附 亚甲基蓝
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大豆分离蛋白基共聚物SPI/AGC水凝胶的制备研究 预览
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作者 杨英 杨艳丽 《药学研究》 CAS 2019年第10期580-583,共4页
目的制备大豆分离蛋白基共聚物水凝胶。方法以大豆分离蛋白(SPI)为基材,丙烯酰胺(AM)和壳聚糖(CS)为单体,水溶性的过硫酸铵(APS)为引发剂,N,N′-亚甲基双丙烯酰胺(MBA)作为交联剂,利用原位聚合原理,制备大豆分离蛋白/丙烯酰胺和壳聚糖... 目的制备大豆分离蛋白基共聚物水凝胶。方法以大豆分离蛋白(SPI)为基材,丙烯酰胺(AM)和壳聚糖(CS)为单体,水溶性的过硫酸铵(APS)为引发剂,N,N′-亚甲基双丙烯酰胺(MBA)作为交联剂,利用原位聚合原理,制备大豆分离蛋白/丙烯酰胺和壳聚糖共聚物(SPI/AGC)水凝胶。结果采用红外光谱(FT-IR)、扫描电子显微镜(SEM)和热重分析(TG)对大豆分离蛋白/丙烯酰胺和壳聚糖共聚物水凝胶表征结构形貌等,表明本水凝胶制备成功。结论以大豆分离蛋白为基材,丙烯酰胺和壳聚糖为单体,水溶性的过硫酸铵为引发剂,N,N′-亚甲基双丙烯酰胺作为交联剂,利用原位聚合原理,制备大豆分离蛋白/丙烯酰胺和壳聚糖共聚物水凝胶,采用红外光谱、扫描电子显微镜和热重分析对大豆分离蛋白/丙烯酰胺和壳聚糖共聚物水凝胶表征结构形貌等,表明本水凝胶制备成功,具有理想规则的多孔结构凝胶有望作为药物载体。 展开更多
关键词 大豆分离蛋白 共聚物 水凝胶
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两性离子水凝胶的制备及性能研究 预览
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作者 王雷 李亮 +6 位作者 张潇 王建海 任波 伍亚军 马淑芬 刘广燕 郭娜 《应用化工》 CAS CSCD 北大核心 2019年第4期780-784,788共6页
研制了一种羧基化石墨烯 GO和两性离子基团修饰的两性水凝胶(ZMPA),在不同温度下,利用水和不同盐类对 ZMPA的吸水溶胀能力进行了系统研究。通过缔合作用而形成的两性离子水凝胶颗粒可在高温度和高盐度条件下,其溶胀能力将突然增加,这说... 研制了一种羧基化石墨烯 GO和两性离子基团修饰的两性水凝胶(ZMPA),在不同温度下,利用水和不同盐类对 ZMPA的吸水溶胀能力进行了系统研究。通过缔合作用而形成的两性离子水凝胶颗粒可在高温度和高盐度条件下,其溶胀能力将突然增加,这说明ZMPA对温度和盐度有着较为敏感的适应性。ZMPA在80℃时具有优异的封堵性能,封堵效率高达93.8%,而20℃时的效率仅为33.3%。羧基化石墨烯GO的加入可提高ZMPA的力学稳定性,同时可使 ZMPA在外界环境 pH发生改变时更好的做出响应。 展开更多
关键词 水凝胶 高温高盐度 溶胀性 力学稳定性 封堵性能
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Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release
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作者 Xiao-Qiu Dou Chang-Li Zhao +3 位作者 Nabila Mehwish Ping Li Chuan-Liang Feng Holger Schonherr 《高分子科学:英文版》 SCIE CAS CSCD 2019年第5期437-443,共7页
Photoresponsive hydrogels have been attractive because they can provide precise spatial and temporal control for molecule release, whereas the conventional preparation of photoresponsive hydrogels generally involves c... Photoresponsive hydrogels have been attractive because they can provide precise spatial and temporal control for molecule release, whereas the conventional preparation of photoresponsive hydrogels generally involves complex chemical synthesis steps or specific conditions which limits their practical applications. Herein, a new photoresponsive hydrogel is facilely prepared via co-assembly of two simple molecules, Fmoc-Phe-OH and Azp, without chemical synthesis. The co-assembly mechanism, morphology, and photoresponsiveness of(Fmoc-Phe-OH)-Azp hydrogel are investigated by circular dichroism(CD), ultraviolet-visible(UV-Vis), fluorescence,~1 H nuclear magnetic resonance(~1 H-NMR), attenuated total internal reflection Fourier transform Infrared(ATR-FTIR) spectroscopy, and scanning electron microscopy(SEM). Furthermore, the enhanced release of encapsulated sulforhodamine B(SRB) dye molecules can be achieved via UV light irradiation. The enhanced dye release amount can be controlled by manipulating photoirradiation time. This study provides a facile way to prepare photoresponsive hydrogel which holds great potential for controllable drug release. 展开更多
关键词 PHOTORESPONSIVE Supromolecular Co-assembly HYDROGEL DYE RELEASE
水凝胶负载BiOI活化过一硫酸盐降解尼泊金甲酯 预览
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作者 胡优优 李正魁 《中国环境科学》 EI CAS CSCD 北大核心 2019年第8期3249-3254,共6页
以辐射聚合法合成的水凝胶为载体,采用化学沉淀法制备水凝胶基碘氧化铋复合光催化剂(p(HEA-APTMACl)-BiOI).应用扫描电子显微镜(SEM),X射线能谱仪(EDS)和X射线粉末衍射仪(XRD)对材料进行表征,结果显示,BiOI成功负载于水凝胶上.p(HEA-APT... 以辐射聚合法合成的水凝胶为载体,采用化学沉淀法制备水凝胶基碘氧化铋复合光催化剂(p(HEA-APTMACl)-BiOI).应用扫描电子显微镜(SEM),X射线能谱仪(EDS)和X射线粉末衍射仪(XRD)对材料进行表征,结果显示,BiOI成功负载于水凝胶上.p(HEA-APTMACl)-BiOI活化过一硫酸盐(PMS)于可见光下可有效降解尼泊金甲酯(MP).探究氧化剂投加量、BiOI负载量、MP初始浓度等因素对MP降解效率的影响,结果表明,p(HEA-APTMACl)、BiOI与PMS存在协同作用,且在MP初始浓度为0.328mmol/L,PMS浓度为1.5mmol/L,催化剂投加量为0.1g条件下,2h内MP去除率高达99%.Cl-对MP降解速率有促进作用,SO4^ 2-则相反,且HCO3-会抑制MP降解效率,NO3-和H2PO4-对MP降解影响较小. 展开更多
关键词 水凝胶 碘氧化铋 过一硫酸盐 尼泊金甲酯
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聚乙烯醇二维光子晶体水凝胶的制备及乙醇响应行为 预览
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作者 任宸锐 刘根起 +2 位作者 秦夏彤 刘晨辉 范晓东 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2019年第7期1520-1526,共7页
以单分散的聚苯乙烯微球乳液为原料,采用针尖注射法制备了聚苯乙烯二维光子晶体阵列,采用聚乙烯醇填充二维光子晶体阵列,以戊二醛为交联剂,得到聚乙烯醇二维光子晶体水凝胶(PVA·2DPCH).通过测定PVA·2DPCH在不同浓度的乙醇/水... 以单分散的聚苯乙烯微球乳液为原料,采用针尖注射法制备了聚苯乙烯二维光子晶体阵列,采用聚乙烯醇填充二维光子晶体阵列,以戊二醛为交联剂,得到聚乙烯醇二维光子晶体水凝胶(PVA·2DPCH).通过测定PVA·2DPCH在不同浓度的乙醇/水溶液中的德拜环直径(D)变化,研究了PVA·2DPCH对乙醇的响应行为.结果表明,在乙醇体积分数为0~60%范围内,PVA·2DPCH对乙醇没有明显响应,德拜环直径基本保持不变;当乙醇体积分数超过60%时,PVA·2DPCH对乙醇表现出敏感响应,其德拜环直径随乙醇体积分数的增大而增大,响应时间仅需30 s;在乙醇体积分数为60%~100%范围内,PVA·2DPCH的德拜环直径变化(ΔD)与乙醇体积分数(Ve)呈线性相关:当60%≤Ve≤75%时,其线性回归方程为ΔD=50.30 Ve-31.74,r^2=0.9734;当75%<Ve≤100%时,其线性回归方程为ΔD=111.14 Ve-74.03,r^2=0.9902.以制备的PVA·2DPCH为乙醇传感器,利用德拜环法测定市售酒精消毒液中乙醇含量,方法简单快速,兼具无标记、可视化检测的特点. 展开更多
关键词 二维光子晶体 水凝胶 聚乙烯醇 乙醇检测 德拜环
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一种抗菌水凝胶的制备及性能研究 预览
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作者 宋天龙 杨娟 +5 位作者 林家洪 刘永龙 陶宏兵 黄泽彬 黄小茉 谢小保 《工业微生物》 CAS 2019年第5期54-57,共4页
以阿拉伯树胶、聚乙烯醇等为原料,通过戊二醛交联成功制备了具有pH和温度敏感的水凝胶,通过溶液吸附法制备了负载水杨酸的水凝胶。分别研究了pH和温度对水凝胶溶胀性能的影响,以及pH和温度对负载水凝胶的缓释性能。实验结果表明,水凝胶... 以阿拉伯树胶、聚乙烯醇等为原料,通过戊二醛交联成功制备了具有pH和温度敏感的水凝胶,通过溶液吸附法制备了负载水杨酸的水凝胶。分别研究了pH和温度对水凝胶溶胀性能的影响,以及pH和温度对负载水凝胶的缓释性能。实验结果表明,水凝胶对pH和温度有敏感性;负载水杨酸的水凝胶在中性介质下的缓释性能要好于酸性和碱性介质,水凝胶缓释性能受温度影响,随着温度升高,缓释性能提高,凝胶的缓释性与溶胀行为一致。 展开更多
关键词 聚乙烯醇 阿拉伯树胶 水凝胶 缓释性能
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Dye removal by eco-friendly physically cross-linked double network polymer hydrogel beads and their functionalized composites
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作者 Yan Kong Yuan Zhuang +3 位作者 Zhiyong Han Jianwei Yu Baoyou Shi Kun Han 《环境科学学报:英文版》 SCIE EI CAS CSCD 2019年第4期81-91,共11页
Hydrogels have attracted large attention in wastewater treatment fields due to their low-cost and good interaction with pollutants,among which novel double network hydrogel is an outstanding class.To expand the applic... Hydrogels have attracted large attention in wastewater treatment fields due to their low-cost and good interaction with pollutants,among which novel double network hydrogel is an outstanding class.To expand the application of double network hydrogel in water treatment,in this study,eco-friendly physically cross-linked double network polymer hydrogel beads(DAP)are prepared and studied in depth on the mechanism of Methylene Blue(MB)adsorption;and then the polymer hydrogels are further functionalized by inorganic materials.MB adsorption on DAP favors alkaline condition which is due to the increase of electrostatic attraction and adsorption site,and it reaches equilibrium within 10 hr,which is faster than that of the single network hydrogel beads(SAP).Through thermodynamics study,the process shows to be an exothermic and spontaneous process.The adsorption isotherms are well fitted by Langmuir model,with a maximum monolayer adsorption capacity of 1437.48 mg/g,which is larger than SAP(1255.75 mg/g).After being functionalized with common inorganic materials including activated carbon,Fe3O4and graphene oxide(GO),the composites show to have larger pore sizes and have obvious increases in adsorption capacity especially the one contains GO.Then the composites contains Fe3O4are used as heterogeneous Fenton catalyst which shows to have excellent performance in MB degradation.The results indicate the potential of polymer double network to be functionalized in environmental areas. 展开更多
关键词 Adsorption ALGINATE Poly(vinyl alcohol) HYDROGEL METHYLENE Blue
护肤用壳聚糖基凝胶的制备及性能 预览
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作者 范金石 刘丽娜 +2 位作者 雷东 王超 徐桂云 《山东化工》 CAS 2019年第7期4-6,共3页
以壳聚糖(CS)为主要原料,通过与共混组分聚乙烯醇(PVA)和明胶(GEL)的协同增效作用,制得了护肤用壳聚糖基凝胶。以粘性、成膜情况和成膜时间为指标优化了各组分间的配比与制备工艺,以透光度分析了壳聚糖基凝胶组分间的相容性。结果表明,... 以壳聚糖(CS)为主要原料,通过与共混组分聚乙烯醇(PVA)和明胶(GEL)的协同增效作用,制得了护肤用壳聚糖基凝胶。以粘性、成膜情况和成膜时间为指标优化了各组分间的配比与制备工艺,以透光度分析了壳聚糖基凝胶组分间的相容性。结果表明,该壳聚糖基凝胶组分间的相容性良好,符合面膜QB/T2872-2017标准所规定的感化指标及理化指标,适用于皮肤护理。 展开更多
关键词 凝胶 壳聚糖 共混 护肤 面膜
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Effect of the hyaluronic acid‐poloxamer hydrogel on skin‐wound healing: in vitro and in vivo studies 预览
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作者 Xiaojuan Li Aimin Li +7 位作者 Fan Feng Qiyu Jiang Huiwei Sun Yantao Chai Ruichuang Yang Zhijie Wang Jun Hou Ruisheng Li 《动物模型与实验医学(英文)》 CSCD 2019年第2期107-113,共7页
Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air pe... Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Methods: In the present work, we prepared a hyaluronic acid‐poloxamer (HA‐POL) hydrogel and tested the therapeutic effect of the hydrogel on skin‐wound healing. Results: The HA‐POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA‐POL hydrogel promoted skin‐wound healing and increased protein accumulation in the wound area. HA‐POL hydrogel allowed greater air permeability than Band‐aid, a typical wound covering. Results from transwell assays showed that the HA‐POL hydrogel effectively isolated skin‐wounds from bacterial invasion. Conclusion: This work demonstrates the advantages of using HA‐POL gel materials in the treatment of cutaneous wounds. 展开更多
关键词 HA‐POL HYDROGEL hyaluronic acid POLOXAMER 407 skin‐wound HEALING
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神经营养因子3修饰透明质酸-甲基纤维素水凝胶修复脊髓损伤大鼠神经功能的恢复 预览
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作者 何志江 朱雷 +3 位作者 程世翔 黄揆 陈曹 孙明林 《中国组织工程研究》 CAS 北大核心 2019年第14期2202-2207,共6页
背景:透明质酸-甲基纤维素水凝胶不仅能与短肽序列和生长因子缀合实现缓释,还具有封闭硬脊膜缺损并减轻炎症反应的作用,是治疗脊髓损伤的理想生物材料。目的:探讨透明质酸-甲基纤维素-神经营养因子3水凝胶对大鼠脊髓损伤后神经功能恢复... 背景:透明质酸-甲基纤维素水凝胶不仅能与短肽序列和生长因子缀合实现缓释,还具有封闭硬脊膜缺损并减轻炎症反应的作用,是治疗脊髓损伤的理想生物材料。目的:探讨透明质酸-甲基纤维素-神经营养因子3水凝胶对大鼠脊髓损伤后神经功能恢复的效果。方法:将54只雌性SD大鼠(由解放军军事医学科学院实验动物中心提供)随机分成3组,每组18只:假手术组行T10椎板切除;模型组和实验组行T10椎板切除后,利用动脉瘤夹建立脊髓损伤模型,随后实验组脊髓损伤区域局部注射透明质酸-甲基纤维素-神经营养因子3水凝胶。造模后1d及1,2,3,4,5,6,7,8周行Basso Beattie Bresnahan(BBB)功能评分,造模后4,6,8周行斜板实验,评估后肢功能恢复情况;术后1周,利用ELISA法检测脊髓中炎性因子质量浓度;造模后8周,用免疫组织化学染色观察脊髓空洞面积、胶质纤维酸性蛋白表达、神经再生变化情况。结果与结论:①模型组、实验组造模后各时间点的BBB评分均低于假手术组(P<0.05),实验组造模后4-8周的BBB评分高于模型组(P<0.05);②斜板实验中,模型组、实验组术后各时间点的最大倾斜角均低于假手术组(P<0.05),实验组造模后6,8周的最大倾斜角高于模型组(P<0.05);③实验组、模型组肿瘤坏死因子α、白细胞介素1β、白细胞介素6及白细胞介素10质量浓度高于假手术组(P<0.05),实验组肿瘤坏死因子α、白细胞介素1β、白细胞介素6质量浓度低于模型组(P<0.05),实验组白细胞介素10质量浓度高于模型组(P<0.05);④免疫组织化学染色显示,实验组和模型组胶质纤维酸性蛋白表达多于假手术组,实验组胶质纤维酸性蛋白表达低于模型组;实验组脊髓空洞面积小于模型组(P<0.05);⑤结果表明,脊髓损伤后局部注射透明质酸-甲基纤维素-神经营养因子3水凝胶,能有效抑制炎症反应和星型胶质细胞活化增生,减少纤维瘢痕形成,� 展开更多
关键词 水凝胶 透明质酸 甲基纤维素 神经营养因子3 脊髓损伤 炎症反应 星形胶质细胞 神经保护 组织工程
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有机/无机杂化水凝胶纤维研究进展
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作者 危培玲 陈涛 +2 位作者 陈国印 侯恺 朱美芳 《中国基础科学》 2019年第3期11-16,共6页
有机/无机杂化水凝胶是一类具有三维网络结构的高含水、软湿性材料.近年来,基于杂化水凝胶功能与结构的研究积累,为进一步将水凝胶的本征功能与宏观构筑形式相结合,水凝胶纤维材料研究逐步兴起,并已在仿生结构构筑、生物材料等应用领域... 有机/无机杂化水凝胶是一类具有三维网络结构的高含水、软湿性材料.近年来,基于杂化水凝胶功能与结构的研究积累,为进一步将水凝胶的本征功能与宏观构筑形式相结合,水凝胶纤维材料研究逐步兴起,并已在仿生结构构筑、生物材料等应用领域有重要进展.本文综述了近年来水凝胶纤维在制备技术、新型材料、应用领域等方面的研究进展,总结并评述了水凝胶纤维纺丝新技术的发展,及其面向生物、传感等领域的应用前景,并提出了以水凝胶纤维为媒介实现"人体-材料"互联的智能化构建设想. 展开更多
关键词 有机/无机杂化 水凝肢 水凝股纤维 生物应用
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