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Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders 预览
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作者 Chuan-Jun Zhuo Wei-Hong Hou +5 位作者 De-Guo Jiang Hong-Jun Tian Li-Na Wang Feng Jia Chun-Hua Zhou Jing-Jing Zhu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期817-823,共7页
Neuropsychiatric disorders represent a set of severe and complex mental illnesses,and the exact etiologies of which are unknown.It has been well documented that impairments in the early development of the brain contri... Neuropsychiatric disorders represent a set of severe and complex mental illnesses,and the exact etiologies of which are unknown.It has been well documented that impairments in the early development of the brain contribute to the pathogenesis of many neuropsychiatric disorders.Currently,the diagnosis of neuropsychiatric disorders largely relies on subjective cognitive assessment,because there are no widely accepted biochemical or genetic biomarkers for diagnosing mental illness.Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNA (ncRNA) with a closed-loop structure.In recent years,there have been tremendous advances in our understanding of the expression profiles and biological roles of circRNAs.In the brain,circRNAs are particularly enriched and are expressed more abundantly in contrast to linear counterpart transcripts.They are highly active at neuronal synapses.These features make circRNAs uniquely crucial for understanding brain health,disease,and neuropsychiatric disorders.This review focuses on the role of circRNAs in early brain development and other brain-related processes that have been associated with the development of neuropsychiatric disorders.In addition,we discuss the potential for blood or cerebrospinal fluid circRNAs to be used as novel biomarkers in the early diagnosis of neuropsychiatric disorders.The findings reviewed here may provide new insight into the pathological mechanisms underlying the onset and progression of neuropsychiatric disorders. 展开更多
关键词 AUTISM spectrum DISORDERS bipolar disorder brain exosomal circRNAs microRNAs nerve regeneration NON-CODING RNAS OBSESSIVE-COMPULSIVE DISORDERS SCHIZOPHRENIA
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The polygenic risk in schizophrenia: assessing GWASs and evaluating Clozapine, ECT and other treatment modalities 预览
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作者 Shiruli Dash 《TMR生命研究》 2019年第1期22-30,共9页
Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate f... Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate finding better,more effective treatments and strategies for prevention. One of the current obstacles are the complicated gene etiologies that are involved in the pathophyslology of schizophrenia. So far, an increasing number of clinical and experimental studies show links between schizophrenia treatment and genetic conditions. Here, we analyze the literature on schizophrenia genetics, with a particular focus on the brain, the mind and environmental insults. An overlap of schlzophrenla with other psychotic disorders has also been taken into accunt with an attempt to find a parallel relationship between genetics and treatment. Finally, we summarize all the present-day treatment options for schizophrenia like clozapine and electroconvulslve therapy and also take into consideration the relatively unexplored role of traditional Chinese medicine. 展开更多
关键词 SCHIZOPHRENIA TRADITIONAL Chinese medicine SCHIZOPHRENIA genetic SCHIZOPHRENIA treatment
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长链非编码RNA在中枢神经系统及精神分裂症中作用的研究进展 预览
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作者 方钰 王卫娣 +1 位作者 程影 崔东红 《上海交通大学学报:医学版》 CAS CSCD 北大核心 2019年第2期198-202,共5页
精神分裂症是一种遗传度高达80%的复杂重性精神疾病,有关其遗传成分的确切性质、功能以及遗传机制目前尚不清楚。长链非编码RNA(long non-coding RNA,lncRNA)是在机体中广泛表达的一种转录本,其可通过多种方式调控基因的表达,参与神经... 精神分裂症是一种遗传度高达80%的复杂重性精神疾病,有关其遗传成分的确切性质、功能以及遗传机制目前尚不清楚。长链非编码RNA(long non-coding RNA,lncRNA)是在机体中广泛表达的一种转录本,其可通过多种方式调控基因的表达,参与神经细胞的增殖分化及突触的可塑性等生物学过程。近年来,诸多研究表明lncRNA 在精神分裂症患者和小鼠模型中均表达异常,参与疾病的发生与发展。该文就lncRNA 的生物学特征和基因调控机制以及lncRNA 在中枢神经系统和精神分裂症中的作用进行综述。 展开更多
关键词 长链非编码RNA 中枢神经系统 精神分裂症 Gomafu 精神分裂症断裂基因2 胚腹前脑-2
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Biomarkers of Mental Illness—What Can We Learn from Circadian Heart Rate? 预览
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作者 Hans G. Stampfer Simon B. Dimmitt 《精神病学期刊(英文)》 2019年第2期107-123,共17页
Background: Much research in psychiatry has been a search for diagnostic biomarkers of mental illness but practically useful markers have remained elusive. The problem may be unrealistic expectations and the aim in th... Background: Much research in psychiatry has been a search for diagnostic biomarkers of mental illness but practically useful markers have remained elusive. The problem may be unrealistic expectations and the aim in this paper is to show that the relationship between circadian heart rate and psychiatric status can contribute to useful understanding in this regard. Aim: To discuss the biomarker implications of changes in circadian heart rate (CHR) in psychiatric disorders. Methods: Comparisons of CHR were made between and within individuals receiving treatment for different psychiatric disorders diagnosed according to criteria defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Results: Broadly different DSM-5 disorders are associated with distinctly different changes in CHR. Some disorders are more consistently associated with distinctive changes but CHR does not predict symptoms or specific clinical diagnoses reliably. Changes in CHR, particularly during sleep, are state-dependent. Clinical improvement is associated with normalisation of CHR. Conclusion: Changes in CHR are a part of the physiological changes in mental illness. Distinctly different changes in CHR suggest distinctly different physiological changes that may constitute diagnostic discrimination at a physiological level. An analysis of CHR can add objective adjunct information to clinical assessment and the evaluation of treatment but does not predict symptoms or clinical diagnoses reliably. Much the same is likely to apply to all candidate biomarkers of mental illness. 展开更多
关键词 CIRCADIAN Heart Rate Anxiety Depression MANIA SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA PERSONALITY DISORDER
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Introduction of Music Therapy Incorporated into Cognitive Remediation: A New Approach to Cognitive Dysfunction in Psychiatric Disorders and a Preliminary Report on Its Effects in Schizophrenia 预览
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作者 Naoko Kosugi Chiaki Oshiyama +1 位作者 Naoki Kodama Shin-Ichi Niwa 《精神病学期刊(英文)》 2019年第1期23-38,共16页
Aim: Cognitive dysfunction and negative symptoms interfere social participation in patients with schizophrenia. Cognitive remediation has proven effective for cognitive deficits. While there are few effective treatmen... Aim: Cognitive dysfunction and negative symptoms interfere social participation in patients with schizophrenia. Cognitive remediation has proven effective for cognitive deficits. While there are few effective treatments for the negative symptoms of schizophrenia, music therapy is expected to ameliorate negative symptoms. With the goal of improving both cognitive dysfunction and negative symptoms, we originally developed a program of Music Therapy incorporated into Cognitive Remediation (MTCR). We introduce the MTCR program and our preliminary results of conducting MTCR in patients with schizophrenia. Methods: The program was based on the NEAR (neuropsychological educational approach to cognitive remediation) program. The MTCR program uses instrumental performances and ensemble vocal performances to train cognitive functions, which consists of 30 sessions in total, with each session being 60 minutes long (45 minutes of music, 15 minutes of verbal session). The participants attended sessions semiweekly in groups of fewer than 12 members. We measured the participants’ symptoms twice, before the intervention and after the final session. For both measurements, we used the BACS and BPRS. Thirty-six individuals (26 men, 10 women;average age of 42.4 years) with schizophrenia participated in this study. They participated in an average of 28.2 sessions. Results: BACS total scores (p Conclusions: The present study demonstrated that MTCR program can improve both cognitive dysfunction and negative symptoms of patients with schizophrenia, which implies that it can also potentially facilitate the social participation of such patients. 展开更多
关键词 SCHIZOPHRENIA COGNITIVE REMEDIATION Music Therapy Social PARTICIPATION BACS BPRS
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Factors That Promote Remission in Individuals with Schizophrenia 预览
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作者 Maivor Olsson-Tall Bertil Marklund +3 位作者 Sven Kylén Eric Carlstr?m Lars Helldin Siv B?ck-Pettersson 《护理学期刊(英文)》 2019年第9期935-950,共16页
The knowledge about factors contributing to remission among individuals with schizophrenia is still missing. Studies show that the number of individuals’ reaching remission is varying among psychiatric outpatient car... The knowledge about factors contributing to remission among individuals with schizophrenia is still missing. Studies show that the number of individuals’ reaching remission is varying among psychiatric outpatient care centres. Therefore, the purpose was to investigate case managers (CM) perception of care interventions promoting remission. Semi-structured interviews were conducted with CM (n = 12) and data were analysed with qualitative content analysis. The results show that CM needs to possess competence, master assessment structure and process. These key-points appear to be of crucial importance for a successful promotion of remission among individuals with schizophrenia. 展开更多
关键词 Assessment Case MANAGERS REMISSION TEAMWORK SCHIZOPHRENIA
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利培酮联合多奈哌齐对精神分裂症病人精神症状和认知功能的疗效 预览
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作者 管晓波 徐静文 +3 位作者 刘群 童艳晨 陆峥 刘飞 《青岛大学学报(医学版)》 CAS 2019年第6期657-660,共4页
目的探讨利培酮联合盐酸多奈哌齐对精神分裂症病人精神症状及认知功能的治疗效果。方法选取精神分裂症病人120例,随机分为干预组和对照组。干预组病人联合服用利培酮片和多奈哌齐片,对照组病人只服用利培酮片,共服用24周。分别于治疗前... 目的探讨利培酮联合盐酸多奈哌齐对精神分裂症病人精神症状及认知功能的治疗效果。方法选取精神分裂症病人120例,随机分为干预组和对照组。干预组病人联合服用利培酮片和多奈哌齐片,对照组病人只服用利培酮片,共服用24周。分别于治疗前、治疗12和24周末,采用阳性与阴性症状量表(PANSS)、简易智力状态检查(MMSE)、韦氏记忆量表(WMS)、韦氏成人智力量表(WAIS-RC)对两组病人进行精神症状和认知功能的评定。结果干预组55例、对照组56例完成随访。治疗12、24周末干预组操作IQ、记忆商数评分显著高于对照组(F=7.877~19.075,P<0.01),治疗24周末干预组PANSS的总分、阳性分、阴性分显著低于对照组(F=4.375~6.115,P<0.05)。两因素重复测量方差分析显示,两组PANSS阴性分在不同时间点的数据差异有统计学意义(F=6.616,P<0.01),两组PANSS总分、PANSS阳性分、PANSS阴性分、操作IQ、总IQ、记忆商数评分的分组主效应差异有统计学意义(F=4.027~21.065,P<0.05、0.01)。结论与单用利培酮相比,利培酮联合盐酸多奈哌齐治疗能有效改善精神分裂症病人的精神症状和部分认知功能。 展开更多
关键词 精神分裂症 利哌立酮 多奈哌齐 情感症状 认知 治疗结果
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Comparison of Caregivers of Schizophrenia and Chronic Renal Failure Patients in Terms of Family Burden, Social Support and Psychological Well-Being 预览
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作者 Burak Kulaksizoglu Buket Cinemre 《生物科学与医学(英文)》 2019年第4期33-40,共8页
Objective: Schizophrenia is a lifelong chronic psychiatric disorder with a relatively early onset. Renal failure, a chronic physical disorder has also negative effects on the families and causes a serious burden in a ... Objective: Schizophrenia is a lifelong chronic psychiatric disorder with a relatively early onset. Renal failure, a chronic physical disorder has also negative effects on the families and causes a serious burden in a similar manner. It is aimed in this study to investigate to what extent the burden, social support and psychological wellbeing among the caregivers of schizophrenic patients compare to those of the caregivers of chronic renal failure patients. Methods: Relatives of patients with schizophrenia and chronic renal failure were included in the study. Each group consisted of 30 volunteers. The volunteers completed demographical information questionnaire, Burden Interview Scale (BIS), Multidimensional Scale of Perceived Social Support (MSPSS) and General Health Questionnaire (GSA). Results: A dominance of female caregivers was found in the study. There was no significant difference between the two groups in terms of burden. Among the caregivers of chronic renal failure was a positive correlation both between age and burden and education and social support respectively. It was found out that relatives of chronic renal failure got less social support and reported a poorer psychological wellbeing when compared to the relatives of schizophrenic patients. A negative correlation was found between social support and burden in both of the study groups. Conclusion: The results of this study underline the importance of social support in alleviating the burden of the caregivers of chronic patients. The monitarisation of the psychological states of caregivers of both the schizophrenic and renal failure patients has to be taken into consideration. 展开更多
关键词 SCHIZOPHRENIA CRF BURDEN SOCIAL Support PSYCHOLOGICAL Wellbeing
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Disintegration of the Astroglial Domain Organization May Underlie the Loss of Reality Comprehension in Schizophrenia: A Hypothetical Model 预览
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作者 Bernhard J. Mitterauer 《医学心理学(英文)》 2019年第2期15-35,共21页
A pathophysiological model of the loss of reality comprehension in schizophrenia is proposed. Based on a formalism it is hypothesized that astroglial domains exert an information-categorizing function which becomes pr... A pathophysiological model of the loss of reality comprehension in schizophrenia is proposed. Based on a formalism it is hypothesized that astroglial domains exert an information-categorizing function which becomes progressively lost in the schizophrenic process, caused by functional and structural disintegration of astroglial domains. Unconstrained synaptic neurotransmission functionally disintegrates the astroglial domains. Microdomains located between perisynaptic astroglial processes and the synaptic membrane are interpreted as elementary functional units categorizing synaptic information processing. Unconstrained diffusion of neurotransmitters into the extrasynaptic space leads to the dysfunction of microdomain formation. In parallel, atrophic processes of astroglia progressively break up the connectivity between synaptic and extrasynaptic compartments disrupting astroglial domains. Basically, the organization of astroglia into definite functional and structural units (modules) of astroglial-synaptic information processing may enable the brain to comprehend ontological realms such as subjects and objects in the environment and their distinct qualities. This fundamental capability of cognition is lost in schizophrenia. It is suggested that this ontological confusion of astroglial domain boundaries progressively disorganizes reality comprehension and may represent the basic pathology in schizophrenia underlying the main symptoms of the disorder. Finally, the testing of the model is shortly discussed. 展开更多
关键词 SCHIZOPHRENIA Astroglial DOMAINS DISINTEGRATION LOSS of REALITY COMPREHENSION
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团体绘画艺术治疗对稳定期住院精神分裂症患者生活质量和社会功能的影响 预览
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作者 俞玮 杨振东 +3 位作者 童捷 丁霞兰 邱静 王璟 《护士进修杂志》 2019年第18期1651-1654,共4页
目的探讨团体绘画艺术治疗对住院精神分裂症患者生活质量和社会功能的影响。方法选取采用随机数字表法将110名住院精神分裂症患者分为观察组和对照组各55例;观察组接受团体绘画艺术干预、药物治疗和其他康复活动,对照组仅予药物治疗和... 目的探讨团体绘画艺术治疗对住院精神分裂症患者生活质量和社会功能的影响。方法选取采用随机数字表法将110名住院精神分裂症患者分为观察组和对照组各55例;观察组接受团体绘画艺术干预、药物治疗和其他康复活动,对照组仅予药物治疗和其他康复活动;在接受绘画艺术干预之前和之后两组患者都分别接受精神科评定和心理测验。结果观察组患者干预后SQLS量表总分、各因子分后测评分均降低,且前测-后测差值与对照组比较,差异具有统计学意义(P<0.05);观察组SSPI量表总分、各因子分较干预前均增加,且前测-后测差值均与对照组比较差异均有统计学意义(P<0.05)。结论团体绘画艺术干预可以提高精神分裂症患者的生活质量,改善社会功能。 展开更多
关键词 团体绘画艺术治疗 精神分裂症 精神病患者生活质量 护理
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细胞分裂周期蛋白42在神经系统疾病中机制的研究进展 预览
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作者 胡颖 梁涛 张骏 《医学综述》 2019年第6期1076-1080,1089共6页
细胞分裂周期蛋白42(CDC42)是一种小GTP酶,在细胞的生长、存活、黏附、增殖和迁移等生理过程中发挥重要作用,这些功能参与了神经系统疾病的发病机制。CDC42在精神分裂症、阿尔茨海默病、癫痫、脑卒中等神经系统常见疾病的发病机制中发... 细胞分裂周期蛋白42(CDC42)是一种小GTP酶,在细胞的生长、存活、黏附、增殖和迁移等生理过程中发挥重要作用,这些功能参与了神经系统疾病的发病机制。CDC42在精神分裂症、阿尔茨海默病、癫痫、脑卒中等神经系统常见疾病的发病机制中发挥了重要作用。在精神分裂症中,CDC42可能与背外侧额叶皮质的第3层椎体细胞棘缺失有关;CDC42在额叶皮质功能下调中有必不可少的作用,这可能与阿尔茨海默病的发病机制有关;CDC42的活性降低可能与慢性复发性癫痫的发作减少相关;CDC42还可能通过神经炎症介导了脑卒中引起的脑损伤,这些可能为各种神经系统疾病的诊疗提供新思路。 展开更多
关键词 细胞分裂周期蛋白42 精神分裂症 阿尔茨海默病 癫痫 脑卒中
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BDNF基因多态性与精神分裂症发病及临床症状的相关性
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作者 王玉花 胡强 +7 位作者 杨超 李平 赵阿勐 崔光成 闫凤武 刘艺涵 李树忠 田野 《神经疾病与精神卫生》 2019年第1期48-51,共4页
目的探讨BDNF基因rs2030324和rs11030101多态性与精神分裂症发病及临床症状的关系。方法于2017年1月一2018年1月由齐齐哈尔市精神卫生中心招募200例精神分裂症患者(病例组)及200例健康对照(对照组)纳人研究。毎位研究对象抽取5ml静脉血... 目的探讨BDNF基因rs2030324和rs11030101多态性与精神分裂症发病及临床症状的关系。方法于2017年1月一2018年1月由齐齐哈尔市精神卫生中心招募200例精神分裂症患者(病例组)及200例健康对照(对照组)纳人研究。毎位研究对象抽取5ml静脉血提取基因组DNA,对rs2030324和rsll030101两个位点上下游500bp的序列设计引物,进行PCR扩增,比较rs2030324和rsll030101两个位点在两组人群中的基因频率分布及基因型分布。对病例组采用阳性与阴性症状量表(PANSS)评估临床症状,分析PANSS评分与不同基因型的相关性。结果病例组和对照组在rs2030324和rsl1030101两个位点基因频率分布和基因型分布均具有统计学意义(P﹤0.05)。该两个位点的A等位基因,都是精神分裂症的易感基因,OR值=1.532、1.391;95%CI=1.154~2.034、1.027-1.883。rsll030101位点AT基因型的患者与PANSS阴性症状评分相关,AT基因型的患者阴性症状评分最高。结论BDNF基因rs2030324、rsl1030101位点多态性与汉族人群精神分裂症的发病具有相关性,该两个位点的等位基因A均可能是精神分裂症发病的易感等位基因。rsl1030101位点多态性可能影响精神分裂症的临床表现。 展开更多
关键词 精神分裂症 脑源性神经营养因子 单核苷酸多态性 症状
齐拉西酮与奥氮平治疗精神分裂症的疗效比较 预览
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作者 孙兵 骆明杰 《中国继续医学教育》 2019年第19期127-130,共4页
目的比较利用齐拉西酮与奥氮平治疗早期精神分裂症(schizophrenia,SCH)的疗效及其安全性。方法根据前瞻性研究手段,将入住医院治疗的74例精神分裂症患者分为两组,时间以2015年1月—2018年1月为准。随机分为A组和B组,A组以齐拉西酮治疗,... 目的比较利用齐拉西酮与奥氮平治疗早期精神分裂症(schizophrenia,SCH)的疗效及其安全性。方法根据前瞻性研究手段,将入住医院治疗的74例精神分裂症患者分为两组,时间以2015年1月—2018年1月为准。随机分为A组和B组,A组以齐拉西酮治疗,B组以奥氮平治疗。根据患者治疗8周后阳性与阴性症状量表评分(PANSS)来对比两组疗效及安全性。结果A、B两组疗效分别为91.89%、94.59%,不良反应发生率分别为5.41%、8.11%,P>0.05,差异无统计学意义。结论对于早期精神分裂症患者而言,利用齐拉西酮与奥氮平治疗都有较好的效果,且两者安全性相当,可作为治疗精神分裂症的理想药物。 展开更多
关键词 齐拉西酮 奥氮平 精神分裂症 安全性 疗效 早期
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氨磺必利与利培酮治疗首发精神分裂症疗效和安全性对照研究 预览
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作者 吴徳武 陈晓兰 蒋新伟 《中外医疗》 2019年第6期106-108,共3页
目的分析氨磺必利与利培酮治疗首发精神分裂症疗效和安全性。方法回顾性分析,2016年2月—2018年4月该医院收治的首发精神分裂症患者104例入组,选择氨磺必利治疗对象44例,纳入观察组,选择利培酮治疗对象60例纳入对照组,持续8周。对比治... 目的分析氨磺必利与利培酮治疗首发精神分裂症疗效和安全性。方法回顾性分析,2016年2月—2018年4月该医院收治的首发精神分裂症患者104例入组,选择氨磺必利治疗对象44例,纳入观察组,选择利培酮治疗对象60例纳入对照组,持续8周。对比治疗前后PANSS评分以及个人与社会功能评定量表(TESS)评分,以及治疗期间不良反应发生情况。结果 8周后,观察组PANSS总分、TESS分别为(14.3±5.2)分、(56.7±11.3)分,低于对照组(28.2±8.5)分、(61.5±12.4)分,差异有统计学意义(t=9.602、2.024,P=0.000、0.046 <0.05)。观察组失眠/嗜睡、有不良反应发生率分别为2.27%、29.55%低于对照组18.33%、51.67%,差异有统计学意义(χ~2=6.414、5.851,P=0.010、0.016<0.05)。结论氨磺必利与利培酮治疗首发精神分裂症疗效更好,可以有效的降低PANSS评分,改善社会功能,同时不良反应发生风险更低。 展开更多
关键词 精神分裂症 首发 疗效 不良反应 氨磺必利 利培酮
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精神分裂症社区康复技术对农村患者的作用 被引量:1
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作者 刘国友 刘轲 +2 位作者 宋君伟 孙乃娟 张文佳 《中国健康心理学杂志》 2019年第1期18-21,共4页
目的:探讨精神分裂症社区康复技术对农村社区精神分裂症患者的作用。方法:随机选取在农村社区居住的精神分裂症患者442例,随机分为干预组和对照组,对干预组进行精神分裂症社区康复技术训练,共433例患者完成该研究。经12个月的观察,每3... 目的:探讨精神分裂症社区康复技术对农村社区精神分裂症患者的作用。方法:随机选取在农村社区居住的精神分裂症患者442例,随机分为干预组和对照组,对干预组进行精神分裂症社区康复技术训练,共433例患者完成该研究。经12个月的观察,每3个月用自制一般情况调查表、服药依从性调查表、阳性和阴性症状量表(PANSS)、社会功能筛选评定量表(SDSS)对两组进行测评。结果:两组患者的服药依从性在时间因素以及时间和分组的交互作用有统计学意义(F=36.376,10.079;P<0.001)。不同时点比较(F=0.601,0.040,0.349,7.510,9.236;P=0.438,0.841,0.555,0.006,0.003);PANSS评分在时间因素以及时间和分组的交互作用有统计学意义(F=218.08,28.677;P<0.001)。不同时点比较(F=0.055,0.03,0.916,7.718,11.847;P=0.814,0.863,0.339,0.006,0.001);两组社会功能在时间因素、时间因素和分组的交互作用有统计学意义(F=201.616,44.381;P<0.001)。不同时点比较(F=0.418,0.184,6.443,18.243,34.162;P=0.518,0.668,0.011,<0.001,<0.001)。结论:精神分裂症社区康复技术对农村社区精神分裂症患者具有提高服药依从性,有效的缓解患者症状、提高社会功能作用。 展开更多
关键词 精神分裂症 康复 症状 社会功能 社区
二甲双胍对伴发糖尿病的精神分裂症患者认知功能的影响
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作者 王彩侠 施小平 +3 位作者 朱闻 孟召海 江珉娅 易正辉 《神经疾病与精神卫生》 2019年第1期52-55,共4页
目的探讨二甲双胍对伴发糖尿病的精神分裂症患者认知功能的影响。方法选择2016年1月一2017年12月在上海市金山区精神卫生中心住院的100例伴发糖尿病的精神分裂症患者作为研究对象,采用随机数字表法分为对照组和观察组各50例。对照组给... 目的探讨二甲双胍对伴发糖尿病的精神分裂症患者认知功能的影响。方法选择2016年1月一2017年12月在上海市金山区精神卫生中心住院的100例伴发糖尿病的精神分裂症患者作为研究对象,采用随机数字表法分为对照组和观察组各50例。对照组给予非典型抗精神病药物+常规降血糖药物+安慰剂治疗,观察组给予非典型抗精神病药物+常规降血糖药物+二甲双胍治疗。观察两组治疗前后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HhAlc)、重复性成套神经心理状态测验(RBANS)评分,统计两组治疗过程中的不良反应。结果两组治疗后FPG、2hPG、HhAlc水平与治疗前相比较均显著降低(P﹤0.05),且观察组与同期对照组相比降低更明显(P﹤0.05)。两组治疗后即刻记忆、视觉广度、言语功能、注意功能和RBANS总分与治疗前相比均显著升高(P﹤0.05),且观察组与同期对照组相比升高更明显(P﹤0.05)。研究过程中两组均未见低血糖等严重不良反应,肝肾功能均未见异常,安全性良好。结论精神分裂症合并糖尿病的患者在常规治疗的基础上联合二甲双胍治疗可改善认知功能,安全性良好。 展开更多
关键词 精神分裂症 糖尿病 2型 认知障碍 二甲双胍
综合护理干预对长期住院精神分裂症患者康复效果的影响 预览
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作者 张滢滢 沈静霞 《中国卫生标准管理》 2019年第14期129-131,共3页
目的分析探讨综合护理干预对长期住院精神分裂症患者的康复效果的影响。方法研究样本为我院2016年10月-2018年10月收治的92例精神分裂症患者,依据简单分组的方法均分为对照组以及护理组,每组均为46例患者。予以对照组患者常规护理,予以... 目的分析探讨综合护理干预对长期住院精神分裂症患者的康复效果的影响。方法研究样本为我院2016年10月-2018年10月收治的92例精神分裂症患者,依据简单分组的方法均分为对照组以及护理组,每组均为46例患者。予以对照组患者常规护理,予以护理组患者综合护理,对两组的干预效果进行比较。结果干预前,两组患者PANSSE评分及GQOL评分差异无统计学意义(P>0.05);干预后,护理组及对照组患者PANSS评分分别为(21.71±4.87)分、(30.32±5.32)分,而GQOL评分分别为(87.24±5.92)分、(78.06±6.47)分,PANSS评分均下降,GQOL评分均升高,且护理组优于对照组,组间差异具有统计学意义(P<0.05)。结论长期住院精神分裂症患者采用综合护理干预可以有效的改善患者的临床症状,提高生活质量,效果确切。 展开更多
关键词 综合护理 长期住院 精神分裂症 生活质量 临床症状 护理效果
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rTMS联合常规药物治疗精神分裂症伴强迫症的临床观察 被引量:1
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作者 刘琴 《中国健康心理学杂志》 2019年第1期21-25,共5页
目的:探讨rTMS联合常规药物治疗精神分裂症伴强迫症的影响。方法:选取我院2013年3月-2016年3月72例精神分裂症伴强迫症患者为研究对象,将纳入患者随机抽签分为观察组与对照组,每组36例。对照组在抗精神病治疗基础上加用氟西汀,观察组在... 目的:探讨rTMS联合常规药物治疗精神分裂症伴强迫症的影响。方法:选取我院2013年3月-2016年3月72例精神分裂症伴强迫症患者为研究对象,将纳入患者随机抽签分为观察组与对照组,每组36例。对照组在抗精神病治疗基础上加用氟西汀,观察组在对照组基础上给予高频率重复经颅磁刺激,比较血清素、磁共振氢质子波谱、事件相关电位P300、精神症状、强迫症状、不良反应。结果:观察组治疗4周后额叶氮-乙酰天门冬氨酸(NAA)/肌酸(Cr)、N1波幅、P3波幅显著高于对照组(t=2.436,3.201,4.774;P<0.05)。观察组治疗4周后精神症状总分(PANSS)、强迫症状总分(DY-BOCS)显著低于对照组的(t=7.236,3.721;P<0.01)。结论:高频率重复经颅磁刺激可以提高大脑皮质兴奋性,联合氟西汀可以有效改善精神分裂症状与强迫症状。 展开更多
关键词 精神分裂症 强迫症 高频率重复经颅磁刺激 氟西汀
慢性精神分裂症患者庇护性就业训练的疗效观察 预览
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作者 杨彩霞 《医学信息》 2019年第6期120-122,共3页
目的探讨庇护性就业形式的职业治疗对慢性精神分裂症患者症状及功能改善的评价。方法选取2017年8月~12月我院收治的44例慢性精神分裂症患者,随机分为干预组和对照组,每组22例。对照组予以药物治疗,干预组在药物治疗的同时施以庇护性就... 目的探讨庇护性就业形式的职业治疗对慢性精神分裂症患者症状及功能改善的评价。方法选取2017年8月~12月我院收治的44例慢性精神分裂症患者,随机分为干预组和对照组,每组22例。对照组予以药物治疗,干预组在药物治疗的同时施以庇护性就业训练,干预前后对两组患者的症状、认知功能、日常生活能力、社交技能、社会适应功能进行比较。结果干预后6个月、12个月干预组阴性症状、一般精神病理学症状及PANSS总分均低于干预前,差异有统计学意义(P<0.05);对照组12个月的阳性症状、阴性症状、一般精神病理学症状及PANSS总分均高于干预前,差异有统计学意义(P<0.05);干预组的MoCA、ADL、社交技能、社会适应功能评分高于干预前,差异有统计学意义(P<0.05);对照组MoCA评分无明显变化,ADL、社交技能、社会适应功能评分均高于干预前,差异有统计学意义(P<0.05)。干预组的MoCA、ADL、社交技能、社会适应功能评分均高于对照组,差异有统计学意义(P<0.05);对照组复发率及再住院率均高于干预组、再就业率低于干预组,差异有统计学意义(P<0.05)。结论庇护性就业形式的职业训练对慢性精神分裂症患者症状有较好的改善,对于患者恢复社会功能起到积极地作用,使患者最大限度的得到全面康复。 展开更多
关键词 庇护性就业 精神分裂症 认知功能 社会功能
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Brain function differences in drug-nave first-episode auditory verbal hallucination-schizophrenia patients with versus without insight
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作者 Min Chen Chuan-Jun Zhuo +2 位作者 Feng Ji Gong-Ying Li Xiao-Yan Ke 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第18期2199-2205,共7页
Background:Few studies have reported brain function differences in drug-na(i)ve first-episode schizophrenia patients who had auditory verbal hallucinations (AVH) with insight vs.those without insight.This study aimed ... Background:Few studies have reported brain function differences in drug-na(i)ve first-episode schizophrenia patients who had auditory verbal hallucinations (AVH) with insight vs.those without insight.This study aimed to investigate brain function differences between drug-naive first-episode AVH-schizophrenia patients with and without insight.Methods:Forty first-episode drug-naive AVH-schizophrenia patients with or without insight and 40 healthy controls between December 2016 and December 2018 were recruited in this study.The auditory hallucinations rating scale (AHRS) was used to assess AVH severity,while the insight and treatment attitudes questionnaire was used to distinguish insight.The global functional connectivity density (gFCD) between different groups was compared using a voxel-wise one-way analysis of covariance.The relationship between gFCD and AHRS total scores were analyzed using voxel-wise multiple regression.Results:Finally,13 first-episode drug-naive AVH-schizophrenia patients with insight,15 AVH-schizophrenia patients without insight,and 20 healthy controls were included for analysis.Except for global assessment of functioning scores,there were no significant differences in sociodemographic information between the AVH-schizophrenia and healthy groups (P > 0.05).Compared to the healthy controls,AVH-schizophrenia patients with insight demonstrated a decreased gFCD in the supramarginal gyrus within the primary auditory cortex,while those without insight demonstrated an increased gFCD in the inferior frontal gyrus and superior temporal gyrus and decreased gFCD in the supplemental motor area.Compared to the AVH-schizophrenia patients with insight,those without insight demonstrated an increased gFCD in the supra-marginal gyrus and posterior superior temporal lobule and a decreased gFCD in the frontal lobe.No significant correlation between gFCD and AVH severity (AHRS total score:r =0.23,P =0.590;and frequency:r =0.42,P =0.820) was found in both AVH-schizophrenia groups.Condusions:The gFCD-aberrant brain 展开更多
关键词 AUDITORY VERBAL HALLUCINATIONS SCHIZOPHRENIA INSIGHT Global functional connectivity density
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