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Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury:a meta-analysis 预览
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作者 Bao-Ping Xu Min Yao +4 位作者 Zhen-Jun Li Zi-Rui Tian Jie Ye Yong-Jun Wang Xue-Jun Cui 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期482-490,共9页
Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury.Data sources:Using“spinal cord injury”,“resveratrol”and“animal experiment”as th... Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury.Data sources:Using“spinal cord injury”,“resveratrol”and“animal experiment”as the main search terms,all studies on the treatment of spinal cord injury in rats by resveratrol were searched for in PubMed,EMBASE,MEDLINE,Web of Science,Science Direct,China National Knowledge Infrastructure,Wanfang,VIP,and SinoMed databases by computer.The search was conducted from their inception date to April 2017.No language restriction was used in the literature search.Data selection:The methodological quality of each study was assessed by the initial Stroke Therapy Academic Industry Roundtable recommendations.Two reviewers independently selected studies according to the title,abstract and full text.The risk of bias in the included studies was also evaluated.Meta-analyses were performed with Review Manager 5.3 software.Outcome measures:Neurological function was assessed by the Basso,Beattie,and Bresnahan scale score,inclined plane score and Gale’s motor function score.Molecular-biological analysis of antioxidative effects was conducted to determine superoxide dismutase levels,malondialdehyde levels,nitric oxide synthase activity,nitric oxide levels,xanthine oxidase and glutathione levels in spinal cord tissues.Results:The methodological quality of the 12 included studies was poor.The results of meta-analysis showed that compared with the control group,resveratrol significantly increased the Basso,Beattie,and Bresnahan scale scores after spinal cord injury(n=300,mean difference(MD)=3.85,95%confidence interval(CI)[2.10,5.59],P<0.0001).Compared with the control group,superoxide dismutase levels were significantly elevated(n=138,standardized mean difference(SMD)=5.22,95%CI[2.98,7.45],P<0.00001),but malondialdehyde levels were significantly diminished(n=84,SMD=–3.64,95%CI[–5.84,–1.43],P=0.001)in the spinal cord of the resveratrol treatment group.Conclusions:Resveratrol promoted neurologi 展开更多
关键词 ANTIOXIDATION META-ANALYSIS NEUROLOGICAL recovery PHARMACOTHERAPY RATS RESVERATROL spinal cord injury systematic review
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Animal models used to study direct peripheral nerve repair:a systematic review 预览
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作者 Francisco Javier Vela Guadalupe Martínez-Chacón +3 位作者 Alberto Ballestín JoséLuis Campos Francisco Miguel Sánchez-Margallo Elena Abellán 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期491-502,共12页
Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severi... Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical skills.Despite the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being studied.Pre-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair studies.Data sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed databases.Data selection:Only preclinical trials on direct nerve repair were included in this review.The articles were evaluated by the first two authors,in accordance with predefined data fields.Outcome measures:The primary outcomes included functional motor abilities,daily activity and regeneration rate.Secondary outcomes included coaptation technique and animal model.Results:This review yielded 267 articles,of which,after completion of the screening,49 studies were analyzed.There were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical models.The nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the rat.Other animal models are also used but the cost-benefit of the rat model provides several strengths over the others.Suture techniques are currently the first option for 展开更多
关键词 NERVE MICROSURGERY peripheral NERVE regeneration REPAIR reconstruction DIRECT NERVE REPAIR animal model coaptation PRISMA systematic review
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Effect of docosahexaenoic acid on the recovery of motor function in rats with spinal cord injury:a meta-analysis 预览
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作者 Zi-Rui Tian Min Yao +4 位作者 Long-Yun Zhou Yong-Jia Song Jie Ye Yong-Jun Wang Xue-Jun Cui 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期537-547,共11页
Objective:Studies have shown that docosahexaenoic acid(DHA)has a beneficial effect in the treatment of spinal cord injury.A meta-analysis was used to study the effect of DHA on the neurological recovery in the rat spi... Objective:Studies have shown that docosahexaenoic acid(DHA)has a beneficial effect in the treatment of spinal cord injury.A meta-analysis was used to study the effect of DHA on the neurological recovery in the rat spinal cord injury model,and the relationship between the recovery of motor function after spinal cord injury and the time and method of administration and the dose of DHA.Data source:Published studies on the effect of DHA on spinal cord injury animal models from seven databases were searched from their inception to January 2019,including PubMed,MEDLINE,EMBASE,the China National Knowledge Infrastructure,Wanfang,VIP,and SinoMed databases.The search terms included“spinal cord injury”“docosahexaenoic acid”,and“rats”.Data selection:Studies that evaluated the influence of DHA in rat models of spinal cord injury for locomotor functional recovery were included.The intervention group included any form of DHA treatment and the control group included treatment with normal saline,vehicle solution or no treatment.The Systematic Review Centre for Laboratory animal Experimentation’s risk of bias assessment tool was used for the quality assessment of the included studies.Literature inclusion,quality evaluation and data extraction were performed by two researchers.Meta-analysis was then conducted on all studies that met the inclusion criteria.Statistical analysis was performed on the data using RevMan 5.1.2.software.Outcome measures:The primary outcome measure was the score on the Basso,Beattie,and Bresnahan scale.Secondary outcome measures were the sloping plate test,balance beam test,stair test and grid exploration test.Results:A total of 12 related studies were included,3 of which were of higher quality and the remaining 9 were of lower quality.The highest mean Basso,Beattie,and Bresnahan scale score occurred at 42 days after DHA treatment in spinal cord injury rats.At 21 days after treatment,the mean difference in Basso,Beattie,Bresnahan scores between the DHA group and the control group was the most 展开更多
关键词 DHA docosahexaenoic ACID FATTY ACID META-ANALYSIS MOTOR FUNCTION MOTOR FUNCTION RECOVER polyunsaturated FATTY ACID PUFA spinal cord injury systematic review
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Prevalence of amblyopia in congenital blepharoptosis: a systematic review and Meta-analysis
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作者 Jia-Ying Zhang Xiao-Wei Zhu +2 位作者 Xia Ding Ming Lin Jin Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1187-1193,共7页
AIM: To con duct a systematic review and Meta-analysis of the published literature to evaluate the pooled prevalence rate of amblyopia in patients with congenital ptosis.METHODS: We searched the PubMed, Embase, the Co... AIM: To con duct a systematic review and Meta-analysis of the published literature to evaluate the pooled prevalence rate of amblyopia in patients with congenital ptosis.METHODS: We searched the PubMed, Embase, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Data, and Chongqing VIP databases for studies reporting the prevalence of amblyopia in patients with congenital ptosis. The reference lists of relevant studies were scanned. Heterogeneity of effect sizes across studies was tested. We calculated prevalence ratios to compare prevale nee estimates for different causes of amblyopia in patients with congenital ptosis, as well as for different geographical regions, year of publication and sample size in subgroup analyses. A systematic review and Meta-analysis were performed.RESULTS: We identified 29 eligible surveys with a total population of 2436. Prevalence rates of amblyopia ranged from 13.8% to 69%. We noted substantial heterogeneity in prevalence estimates for amblyopia in congenital ptosis (Cochran's χ2 significant at P<0.0001;I^2=90%). The pooled prevalence using random-effects models of 29 studies was 32.8%(95%CI: 27.3%-38.4%) in the overall population. Compared to the overall pooled prevalence, amblyopia prevalence was higher in studies in which only subjects with blepharophimosis syndrome were included. CONCLUSION: We con firm that nearly on e-third of congenital ptosis patients are suffering from or at risk for amblyopia. Patients with blepharophimosis syndrome are more likely to develop amblyopia. The identification and management of amblyopia should be integral to the treatment of congenital ptosis. 展开更多
关键词 AMBLYOPIA CONGENITAL PTOSIS BLEPHAROPHIMOSIS systematic review
Investigational growth factors utilized in animal models of spinal fusion: Systematic review 预览
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作者 Ethan Cottrill A Karim Ahmed +10 位作者 Noah Lessing Zachary Pennington Wataru Ishida Alexander Perdomo-Pantoja Sheng-fu Lo Elizabeth Howell Christina Holmes C Rory Goodwin Nicholas Theodore Daniel M Sciubba Timothy F Witham 《世界骨科杂志(英文版)》 2019年第4期176-191,共16页
BACKGROUND Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current “gold standard” treatment. Tissue e... BACKGROUND Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current “gold standard” treatment. Tissue engineering has the potential to solve this problem via the creation of bone grafts involving bone-promoting growth factors (e.g., bone morphogenetic protein 2). A broad assessment of experimental growth factors is important to inform future work and clinical potential in this area. To date, however, no study has systematically reviewed the investigational growth factors utilized in preclinical animal models of spinal fusion. AIM To review all published studies assessing investigational growth factors for spinal fusion in animal models and identify promising agents for translation. METHODS We conducted a systematic review of the literature using PubMed, Embase, Cochrane Library, and Web of Science databases with searches run on May 29th, 2018. The search query was designed to include all non-human, preclinical animal models of spinal fusion reported in the literature without a timespan limit. Extracted data for each model included surgical approach, level of fusion, animal species and breed, animal age and sex, and any other relevant characteristics. The dosages/sizes of all implant materials, spinal fusion rates, and follow-up time points were recorded. The data were analyzed and the results reported in tables and text. PRISMA guidelines were followed for this systematic review. RESULTS Twenty-six articles were included in this study, comprising 14 experimental growth factors: AB204 (n = 1);angiopoietin 1 (n = 1);calcitonin (n = 3);erythropoietin (n = 1);basic fibroblast growth factor (n = 1);growth differentiation factor 5 (n = 4), combined insulin-like growth factor 1 + transforming growth factor beta (n = 4);insulin (n = 1);NELL-1 (n = 5);noggin (n = 1);P-15 (n = 1);peptide B2A (n = 2);and secreted phosphoprotein 24 (n = 1). The fusion rates of the current gold standard treatment (autologous ili 展开更多
关键词 SPINAL FUSION Growth FACTOR PSEUDOARTHROSIS Systematic REVIEW
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基于灰色综合评价的毕业要求达成度评价与解析
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作者 瞿英 范默苒 +1 位作者 邵冬 吴长莉 《数学的实践与认识》 北大核心 2019年第11期254-260,共7页
毕业要求达成度是基于学习产出教育模式(Outcomes-based Education,OBE)的核心概念,对其评价的合理性直接影响到OBE教育模式的实施效果.以工程教育认证标准对毕业要求的12条能力中的研究能力综合评价为例,以信息管理与信息系统专业的人... 毕业要求达成度是基于学习产出教育模式(Outcomes-based Education,OBE)的核心概念,对其评价的合理性直接影响到OBE教育模式的实施效果.以工程教育认证标准对毕业要求的12条能力中的研究能力综合评价为例,以信息管理与信息系统专业的人才培养目标及学生的毕业要求为依托,建立研究能力指标点与支撑课程关系,形成毕业能力达成度评价指标,运用古林法确定各指标点课程的重要性,避免了主观赋权的弱点;运用灰色综合评价法,对毕业生个体毕业研究能力达成度进行评价,并建立毕业班级整体毕业研究能力达成度的两种评价方法,通过对比研究,给出评价方法使用建议,为OBE实施过程中科学有效评价毕业要求达成度提供方法上指导. 展开更多
关键词 成果导向 毕业要求达成度 灰色综合评价法 系统评价
法律行为的非有效及相关概念的体系化难点——以澳门现行法之规则为起点 预览
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作者 唐晓晴 王星 《求是学刊》 CSSCI 北大核心 2019年第1期119-130,共12页
'非有效'一词用来表示法律行为不发生预定效力的状态,然而它并不是一个被广泛认同的术语。实际上,关于效力的术语在罗马法当中就没有什么章法,《德国民法典》也并没有完成效力否定的体系化工作。相关术语在学理解释和法律移植... '非有效'一词用来表示法律行为不发生预定效力的状态,然而它并不是一个被广泛认同的术语。实际上,关于效力的术语在罗马法当中就没有什么章法,《德国民法典》也并没有完成效力否定的体系化工作。相关术语在学理解释和法律移植过程中,又随着时间而不断演化,生出了更多疑窦。可见,效力否定术语难以体系化的现象,只能在术语的使用中逐渐积累共识,再加以解决。因为这种混乱的形成,本就是历史的结果,是文化的结果,而不是始发的预先安排。 展开更多
关键词 法律行为非有效 无效 可撤销 体系化
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Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis 预览
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作者 Xin-Xing Tantai Long-Bao Yang +4 位作者 Zhong-Cao Wei Cai-Lan Xiao Li-Rong Chen Jin-Hai Wang Na Liu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第21期2683-2698,共16页
BACKGROUND Several studies have explored the association between the use of proton pump inhibitors (PPIs) and the risk of developing hepatic encephalopathy (HE) in patients with advanced liver disease. However, the ev... BACKGROUND Several studies have explored the association between the use of proton pump inhibitors (PPIs) and the risk of developing hepatic encephalopathy (HE) in patients with advanced liver disease. However, the evidence-based conclusions are controversial. We hypothesized that using PPIs may increase the risk of HE in patients with advanced liver disease. If confirmed, clinicians must strictly adhere to the indications for PPI treatment in this population. AIM To evaluate the pooled risk of HE in patients with advanced liver disease who use PPIs. METHODS Three electronic databases (PubMed, EMBASE, and the Cochrane Library) were searched from the date of database inception through January 8, 2019 to identify comparative studies evaluating the association between PPI use and the risk of HE. Data from the included studies were extracted. The random-effects model was used for pooling risk estimates and the corresponding 95% confidence intervals (CIs). Subgroup and sensitivity analyses were also performed. RESULTS In total, 4342 patients from five case-control studies and 188053 patients from four cohort studies were included in this analysis. In patients with advanced liver disease, PPI use was associated with an elevated risk of developing HE, with significant heterogeneity. The pooled odds ratio for case-control studies was 2.58 (95%CI: 1.68-3.94, I2 = 72%). The pooled RR for cohort studies was 1.67 (95%CI: 1.30-2.14, I2 = 67%). The results of the subgroup analyses suggested that the heterogeneity may be the result of differences in the study designs and the definitions of PPI use. The sensitivity and subgroup analyses did not alter our findings. CONCLUSION In patients with advanced liver disease, PPI use is associated with an elevated risk of HE. Future large prospective studies are needed to confirm this association. 展开更多
关键词 PROTON PUMP INHIBITORS CIRRHOSIS Hepatic ENCEPHALOPATHY Systematic review META-ANALYSIS
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Prevention and treatment of childhood and adolescent obesity: a systematic review of meta-analyses
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作者 Theodora Psaltopoulou Stamatios Tzanninis +5 位作者 Ioannis Ntanasis-Stathopoulos George Panotopoulos Myrto Kostopoulou Ioannis-Georgios Tzanninis Anastasia Tsagianni Theodoros N.Sergentanis 《世界儿科杂志(英文版)》 2019年第4期350-381,共32页
Background The goal of this systematic review is to synthesize the published meta-analyses assessing the role of nutritional,behavioral and physical activity factors/interventions on the prevention or treatment of ped... Background The goal of this systematic review is to synthesize the published meta-analyses assessing the role of nutritional,behavioral and physical activity factors/interventions on the prevention or treatment of pediatric and adolescent obesity.Methods An online search was conducted in PubMed (end-of-search:September 30,2015);English-language meta-analyses pooling observational and/or interventional studies examining weight-related indices on children and adolescents were included.Results Sixty-six meta-analyses corresponding to more than 900,000 children and adolescents were retrieved.The majority of meta-analyses included interventional studies most of which referred to mixed or combined interventions,including components such as diet,physical activity and sedentary behavior reduction.Discrepancies between meta-analyses on observational and interventional studies were noted.Combined interventions including physical activity and nutritional modifications seemed to represent the most effective means for tackling childhood obesity.Conclusions Synthesis of interventional or observational evidence may yield discrepant results.The combination of enhanced physical activity and improved nutrition emerged as a promising intervention in the fight against childhood/adolescent obesity.However,further research is needed about the most effective multidimensional prevention strategy. 展开更多
关键词 CHILDHOOD OBESITY DIET META-ANALYSIS Physical activity Systematic review
Reporting and methodological quality of systematic reviews or meta-analyses in nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis 预览
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作者 Si-Yuan Yang Li-Min Guo +1 位作者 Yuan Jia Fan-Jie Meng 《TMR食疗与健康管理》 2019年第2期35-43,共9页
Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MA... Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MAs of nasogastric and nasojejunal enteral nutrition for SAP published in the journal before July.1st 2018 were identified by searching the databases of OVID,Cochrane Library,Wiley,PubMed,CNKI,Wanfang Data and VIP.The methodological and reporting quality of included studies was respectively assessed by AMSTAR 2 scale and PRISMA statement.Results:A total of 6 articles included at last.(1)Several issues of methodological quality in 6 studies were reviewed,such as:no prior design,comprehensive searching strategy,assessment of publication bias,the reason for incorporating the type of research design,or the statement of conflict of interest.(2)The average PRISMA score is 18.83±1.97(17-22).Results on the quality of reporting evaluation showed that 5 SRs/MAs were rated as moderate and 1 as high.What’s more,we assessed the quality of indicators of the result by GRADE,but the grade was low.Conclusion:The quality of the involved studies published at home and abroad is uneven,so it is necessary to seek for further improvement of methodology and standardization of reporting to provide high-quality support for evidenced-based decision. 展开更多
关键词 ENTERAL NUTRITION SEVERE acute pancreatiti Systematic review META-ANALYSIS AMSTAR 2 PRISMA
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新时代国际贸易理论与政策课程体系建设问题研究--以北方民族大学国际经济与贸易专业为例 预览
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作者 夏合群 《对外经贸》 2019年第7期144-145,共2页
课程体系建设是专业体系建设和专业课程(群)体系建设的基础。首先分析当前国际贸易理论与政策课程体系存在的问题,接着分析建设系统化的国际贸易理论与政策课程群的意义,提出课程体系建设过程中要与师资队伍、教材建设、实践教学有机结... 课程体系建设是专业体系建设和专业课程(群)体系建设的基础。首先分析当前国际贸易理论与政策课程体系存在的问题,接着分析建设系统化的国际贸易理论与政策课程群的意义,提出课程体系建设过程中要与师资队伍、教材建设、实践教学有机结合,整合课程资源,改革授课方式,形成多层次的专业课程群的构想。对于深化高校课程体系改革,利用"互联网+"等技术建立在线教学平台,促进高校课程体系建设和质量工程的发展有一定的促进作用。 展开更多
关键词 国际贸易理论与政策 课程体系 系统化 互联网+
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Speech databases for mental disorders: A systematic review 预览
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作者 Yiling Li Yi Lin +1 位作者 Hongwei Ding Chunbo Li 《综合精神医学(英文)》 CSCD 2019年第3期119-129,共11页
Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of con... Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of content, speech corpora capture tones, emotions, rhythms and many other signals beyond content. Hence, the design and development of speech corpora for patients with mental disorders is increasingly important. Aim This review aims to extract the existing speech corpora for mental disorders from online databases and peer-reviewed journals in order to demonstrate both achievements and challenges in this area. Methods The review first covers publications or resources worldwide, and then leads to the reports from China, followed by a comparison between Chinese and nonChinese regions. Results Most of the speech databases were recorded in Europe or the United States by audio or video. Some were even supplemented by brain images and Event- Related Potential (ERP) statistics. The corpora were mostly developed for patients with neurocognitive disorders like stutter and aphasia, and mental illness like dementia, while other types of mental illness such as bipolar disorder, anxiety, d即ression and autism were scarce in number in database development. Strengths and limitations The results demonstrated that database development of neurocognitive disorders in China is much scarcer than that in some European countries, but the existing databases pave an instructive road for psychiatric problems. Also, the methods and applications of databases from the leading countries are inspiring for Chinese scholars, who are searchi ng methods for developing a comprehensive resource for clinical studies. 展开更多
关键词 SPEECH DATABASES MENTAL DISORDERS A systematic REVIEW
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Visit-to-visit Systolic Blood Pressure Variability and Stroke Risk: A Systematic Review and Meta-analysis 预览
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作者 Han WANG Min LI +5 位作者 Shu-hua XIE Ye-tong OYANG Min YIN Bing BAO Zhi-ying CHEN Xiao-ping YIN 《当代医学科学(英文)》 SCIE CAS 2019年第5期741-747,共7页
Visit-to-visit variability in systolic blood pressure(SBP)may have an important additional role in increasing the risk of vascular complications,including stroke.We conducted a meta-analysis to assess the relationship... Visit-to-visit variability in systolic blood pressure(SBP)may have an important additional role in increasing the risk of vascular complications,including stroke.We conducted a meta-analysis to assess the relationship between visit-to-visit SBP variability(SBPV)and stroke risk.PubMed,EMBASE,and the Cochrane library databases were searched for cohort studies with data on visit-to-visit SBPV and stroke risk.Studies that reported adjusted relative risks(RRs)with 95%Cis of stroke associated with SBPV were included.Fourteen cohort studies met the inclusion criteria and were included in our meta-analysis.After adjustment for age,sex,and existing vascular risk factors,the analysis showed that the risk of stroke in patients with SBPV was significantly increased compared with patients with a small baseline SBPV[SD(RR=1.20,95%CI=(1.07-1.35),P=0.0005),CV(RR=1.12,95%CI=(1.00-1.26),P=0.008)].In addition,follow-up variations of more than 5 years were associated with a higher risk of stroke than those of less than 5 years[RR=1.08,95%CI=(1.04-1.11)].Visit-to-visit SBPV was associated with an increased risk of stroke,especially in terms of the time of variation.Taken together,SBPV data may be useful as a preventative diagnostic method in the management of stroke. 展开更多
关键词 blood pressure blood pressure variability META-ANALYSIS STROKE systematic review visit-to-visit systolic blood pressure
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Effectiveness of probiotics in irritable bowel syndrome: methodological quality of meta-analyses and systematic reviews 预览
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作者 Yuan Jia Li-Min Guo +2 位作者 Si-Yuan Yang Qian Wu Fan-Jie Meng 《护理前沿(英文)》 CAS 2019年第2期115-121,共7页
Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessm... Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessment scale AMSTAR and explored the factors that influenced the quality of methodology. It was designed to provide a reference for future research and systematic reviews/metaanalysis. Methods: The methodological quality of existing systematic reviews/meta-analysis was evaluated using the AMSTAR scale. Influencing factors of methodological quality were statistically analyzed using RevMan 5.3 software. The included systematic reviews/metaanalysis must include the following characteristics:(1) methods using systematic evaluation/meta-analysis,(2) probiotic intervention, and (3) language limitation to Chinese and English. Results: The AMSTAR score was 5-9 (7.42 ± 1.22), and the quality is above average. The factors affecting the methodological quality are the number of authors and whether they cooperate with the institution. Conclusions: Studies have shown that current systematic reviews/meta-analysis of the effectiveness of probiotics on IBS does not fully comply with methodological quality standards, and therefore the methodological quality of research in this area needs to be strengthened. To better clarify how probiotics affect IBS, future systematic reviews and meta-analyses should not only follow methodological quality standards but also include more effective outcome measures, and they should focus more on the discussion of research results. We look forward to the development of higher-quality randomized controlled trials in the future. 展开更多
关键词 PROBIOTICS IRRITABLE BOWEL syndrome systematic review META-ANALYSIS methodological quality
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常人方法学视角下社会主义核心价值观培育对策研究 预览
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作者 刘玉生 《成都理工大学学报:社会科学版》 2019年第2期26-30,共5页
常人方法学告诉我们,行动主体具有“权宜性”“索引性”和“反身性”等特点,主体间的社会互动正是借此而得以产生和展开。社会主义核心价值观的培育也需要借助于社会互动,而微观的社会互动所具有的“权宜性”“索引性”和“反身性”的... 常人方法学告诉我们,行动主体具有“权宜性”“索引性”和“反身性”等特点,主体间的社会互动正是借此而得以产生和展开。社会主义核心价值观的培育也需要借助于社会互动,而微观的社会互动所具有的“权宜性”“索引性”和“反身性”的特点要求我们在进行社会主义核心价值观培育时,必须要做到培育的情境化、系统化和权威化,唯有如此才能和不同的主体形成全面、持续和有效的社会互动,进而顺利地实施和开展个体的社会化工作,切实推进社会主义核心价值观的培育。 展开更多
关键词 常人方法学 社会主义核心价值观培育 情境化 系统化 权威化
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Comprehensive analysis of the influence of structural and dynamic parameters on the accuracy of nano-precision positioning stages
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作者 Chengyuan LIANG Fang YUAN +3 位作者 Xuedong CHEN Wei JIANG Lizhan ZENG Xin LUO 《机械工程前沿:英文版》 CSCD 2019年第3期255-272,共18页
Nano-precision positioning stages are characterized by rigid-flexible coupling systems. The complex dynamic characteristics of mechanical structure of a stage, which are determined by structural and dynamic parameters... Nano-precision positioning stages are characterized by rigid-flexible coupling systems. The complex dynamic characteristics of mechanical structure of a stage, which are determined by structural and dynamic parameters, exert a serious influence on the accuracy of its motion and measurement. Systematic evaluation of such influence is essential for the design and improvement of stages. A systematic approach to modeling the dynamic accuracy of a nano-precision positioning stage is developed in this work by integrating a multi-rigid-body dynamic model of the mechanical system and measurement system models. The influence of structural and dynamic parameters, including aerostatic bearing configurations, motion plane errors, foundation vibrations, and positions of the acting points of driving forces, on dynamic accuracy is investigated by adopting the H-type configured stage as an example. The approach is programmed and integrated into a software framework that supports the dynamic design of nano-precision positioning stages. The software framework is then applied to the design of a nano-precision positioning stage used in a packaging lithography machine. 展开更多
关键词 nano-precision POSITIONING stage analysis and design structural and DYNAMIC parameters DYNAMIC ACCURACY systematic modeling
Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder:A Systematic Review of Clinical Trials 预览
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作者 Jun LIU Guo-bing WAN +7 位作者 Ming-shi HUANG George Agyapong Tian-le ZOU Xue-ying ZHANG Yen-Wenn LIU Yi-qing SONG Ying-Chieh Tsai Xue-jun KONG 《当代医学科学(英文)》 SCIE CAS 2019年第2期173-184,共12页
The therapeutic potentials of probiotics in autism spectrum disorder(ASD)remains controversial,with the only existing systematic review on this topic published in 2015.Results from new trials have become available in ... The therapeutic potentials of probiotics in autism spectrum disorder(ASD)remains controversial,with the only existing systematic review on this topic published in 2015.Results from new trials have become available in recent years.We therefore conducted an updated systematic review,to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities.Our review includes two randomized controlled trials,which showed improvement of ASD behaviors,and three open trials,all which exhibited a trend of improvement.Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy.Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD. 展开更多
关键词 AUTISM SPECTRUM DISORDER PROBIOTICS systematic review
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Recent advances in endoscopic retrograde cholangiopancreatography in Billroth Ⅱ gastrectomy patients:A systematic review 预览
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作者 Tae Young Park Tae Jun Song 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第24期3091-3107,共17页
BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)in patients with Billroth Ⅱ gastrectomy has been considered a challenging procedure due to the surgically altered gastrointestinal anatomy.However,there ... BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)in patients with Billroth Ⅱ gastrectomy has been considered a challenging procedure due to the surgically altered gastrointestinal anatomy.However,there has been a paucity of comparative studies regarding ERCP in Billroth Ⅱ gastrectomy cases because of procedure-related morbidity and mortality and practical and ethical limitations.This systematic and comprehensive review was performed to obtain a recent perspective on ERCP in Billroth Ⅱ gastrectomy patients.AIM To systematically review the literature regarding ERCP in Billroth Ⅱ gastrectomy patients.METHODS A systematic review was performed on the literature published between May 1975 and January 2019.The following electronic databases were searched:PubMed,EMBASE,and Cochrane Library.The outcomes of successful afferent loop intubation and successful selective cannulation and occurrence of adverse events were assessed.RESULTS A total of 43 studies involving 2669 patients were included.The study designs were 36(83.7%)retrospective cohort studies,4(9.3%)retrospective comparative studies,2(4.7%)prospective comparative studies,and 1(2.3%)prospective cohort study.Of a total of 2669 patients,there were 1432 cases(55.6%)of sideviewing endoscopy,664(25.8%)cases of forward-viewing endoscopy,171(6.6%)cases of balloon-assisted enteroscopy,169(6.6%)cases of anterior obliqueviewing endoscopy,64(2.5%)cases of dual-lumen endoscopy,31(1.2%)cases of colonoscopy,and 14(0.5%)cases of multiple bending endoscopy.The overall success rate of afferent loop intubation was 91.3%(2437/2669),and the overall success rate of selective cannulation was 87.9%(2346/2437).A total of 195 cases(7.3%)of adverse events occurred.The success rates of afferent loop intubation and the selective cannulation rate for each type of endoscopy were as follows:side-viewing endoscopy 98.2%and 95.3%;forward-viewing endoscopy 97.4%and 95.2%;balloon-assisted enteroscopy 95.4%and 97.5%;oblique-viewing endoscopy 94.1%and 97.5%;and dual-lumen endosco 展开更多
关键词 Endoscopic RETROGRADE CHOLANGIOPANCREATOGRAPHY Therapeutic ENDOSCOPE BILLROTH operation ADVERSE event Systematic review
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Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis 预览
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作者 Fernanda P Logiudice Wanderlei M Bernardo +9 位作者 Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura 《世界胃肠内镜杂志:英文版(电子版)》 2019年第4期281-291,共11页
BACKGROUND For palliation of malignant biliary obstruction (MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography (ERCP) with the placement of metallic stents. Endoscopic... BACKGROUND For palliation of malignant biliary obstruction (MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography (ERCP) with the placement of metallic stents. Endoscopic ultrasound (EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure. Recently, however, there have been robust randomized clinical trials (RCTs) comparing EUS-guided drainage and ERCP as primary approaches to MBO. AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO. METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation criteria. RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients (112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96% and 91.81%, respectively, with a risk difference (RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97;I2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of ?0.01%(95%CI:-0.12, 0.10;P = 0.90;I2 = 0%). The mean difference (MD) for the duration of the procedure was -0.12%(95%CI:-8.20, 7.97;P = 0.98;I2 = 84%). In the EUS and ERCP groups, there were 14 and 25 adverse events, respectively, with an RD of -0.06%(95%CI:-0.23, 0.12;P = 0.54;I2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18;P = 0.19;I2 = 44%). The stent dysfunction rate was significantly lower in the EUS group (MD =-0. 展开更多
关键词 Common bile duct neoplasms ENDOSCOPIC retrograde CHOLANGIOPANCREATOGRAPHY ENDOSONOGRAPHY Ultrasonography Interventional/methods ENDOSCOPIC ultrasound Systematic review META-ANALYSIS
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Cautery-assisted palatal stiffening operation for obstructive sleep apnea: A systematic review and meta-analysis
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作者 Charles M.Llewellyn Michael W.Noller Macario Camacho 《世界耳鼻咽喉头颈外科杂志(英文)》 2019年第1期49-56,共8页
Objective:To systematically review outcomes for cautery-assisted palatal stiffening operation (CAPSO) as a treatment for adult obstructive sleep apnea (OSA).Methods:Five databases (including PubMed/MEDLINE) were searc... Objective:To systematically review outcomes for cautery-assisted palatal stiffening operation (CAPSO) as a treatment for adult obstructive sleep apnea (OSA).Methods:Five databases (including PubMed/MEDLINE) were searched through July 12,2017.Results:Eight studies (307 patients) met criteria.Overall,CAPSO alone (80 patients) improved AHI from a mean ± standard deviation (M±SD) of (16.8±11.9) to (9.9±10.9) events/h (41.1% decrease).Mixed CAPSO with/without tonsillectomy (92 patients) improved AHI from a M] SD of (24.8 ± 12.6) to (10.6 ± 9.5) events/h (61.7% decrease).CAPSO with expansion pharyngoplasty (EP),(78 patients) improved AHI from a M ± SD of (26.3 ± 17.7) to (12.6 ± 5.8) events/h (52.1% decrease).CAPSO alone (90 patients) improved lowest oxygen saturation (LSAT) by 5.4 points.Mixed CAPSO with/without tonsillectomy (77 patients) improved LSAT by 10.6 points,and CAPSO with EP (78 patients) improved LSAT by 5.2 points.Sleepiness improved (182 patients) from an Epworth Sleepiness Scale score of 11.8 to 5.1,P < 0.001.Snoring reduced (120 patients) from 7.9 to 2.5 on visual analog scales (0-10 scale),P < 0.001.Conclusions:Apnea-hypopnea index has improved by 41.0% for CAPSO alone,61.7% for CAPSO with tonsillectomy and 52.1% for CAPSO with expansion pharyngoplasty.Additionally,lowest oxygen saturation,sleepiness and snoring have also improved after CAPSO. 展开更多
关键词 Surgery SLEEP APNEA SYNDROMES Systematic review META-ANALYSIS
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