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Extracellular vesicles in the diagnosis and treatment of central nervous system diseases 预览
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作者 Alisa A.Shaimardanova Valeriya V.Solovyeva +3 位作者 Daria S.Chulpanova Victoria James Kristina V.Kitaeva Albert A.Rizvanov 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期586-596,共11页
Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central n... Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems.In many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic proteins.The contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system diseases.Extracellular vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain barrier.Today,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well evidenced.Special attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative diseases.Depending on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and anti-inflammatory.Due to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the brain.This review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles. 展开更多
关键词 biomarkers cell-mediated therapy central nervous system DISEASES diagnosis EXOSOMES EXTRACELLULAR RNAS EXTRACELLULAR vesicles microRNAs MICROVESICLES NEURODEGENERATIVE DISEASES
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Current status and future prospects of stem cell therapy in Alzheimer’s disease 预览
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作者 Fu-Qiang Zhang Jin-Lan Jiang +3 位作者 Jing-Tian Zhang Han Niu Xue-Qi Fu Lin-Lin Zeng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期242-250,共9页
Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only al... Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only alleviate the symptoms without curing the disease, which is a serious issue and influences the quality of life of the patients and their caregivers. In recent years, stem cell technology has provided new insights into the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Currently, the main sources of stem cells include neural stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells. In this review, we discuss the pathophysiology and general treatment of Alzheimer’s disease, and the current state of stem cell transplantation in the treatment of Alzheimer’s disease. We also assess future challenges in the clinical application and drug development of stem cell transplantation as a treatment for Alzheimer’s disease. 展开更多
关键词 Alzheimer's disease β-amyloid drug development embryonic STEM CELLS induced PLURIPOTENT STEM CELLS mesenchymal STEM CELLS nerve REGENERATION NEURAL REGENERATION NEURAL STEM CELLS NEURODEGENERATIVE disorders STEM cell therapy
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Exosomes as mediators of neuron-glia communication in neuroinflammation 预览
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作者 María Pascual Francesc Ibánez Consuelo Guerri 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期796-801,共6页
In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions.These nanovesicles (30–150 nm) co... In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions.These nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal functions.This review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous system.Special emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative disorders.Given the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and neuropathologies.Finally,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation. 展开更多
关键词 biomarkers EXOSOMES glial cells NEUROINFLAMMATION neuron-glia commuication neurons NEUROPATHOLOGY therapy
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肩锁关节脱位研究:如何达到解剖复位和持续性稳定及关节微动 预览
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作者 房燚 赵文志 +5 位作者 潘德悦 韩鑫 张路 何洪涛 石峰 田廷啸 《中国组织工程研究》 CAS 北大核心 2020年第5期796-802,共7页
背景:肩锁关节脱位的治疗方式繁多,尚无统一标准,其治疗效果受损伤机制、脱位类型、治疗方式的选择及术后锻炼等多方面影响。目的:归纳总结目前肩锁关节脱位的研究进展。方法:由第一作者用计算机检索PubMed数据库(2010至2019年),万方数... 背景:肩锁关节脱位的治疗方式繁多,尚无统一标准,其治疗效果受损伤机制、脱位类型、治疗方式的选择及术后锻炼等多方面影响。目的:归纳总结目前肩锁关节脱位的研究进展。方法:由第一作者用计算机检索PubMed数据库(2010至2019年),万方数据库(2010至2019年),以"Acromioclavicular;Dislocation;Diagnosis;Therapy;Anatomical reconstruction;Endobutton;Internal Fixators"为英文检索词,"肩锁关节;脱位;诊断;治疗;解剖重建;Endobutton;骨科植入物"为中文检索词,排除重复性研究,共检索到2 187篇文献,最后保留55篇文献进行归纳总结结果与结论:目前对于RockwoodⅠ、Ⅱ型肩锁关节脱位多采取保守治疗,Ⅳ-Ⅵ型多采取手术治疗,Ⅲ型的治疗尚存争议,为了最大限度地发挥功能,建议年轻和对功能要求高的患者采取积极手术治疗。目前,非手术治疗以吊带固定为主,手术治疗越来越趋向于微创解剖重建喙锁韧带,如关节镜辅助下Endobutton技术,虽能获得良好的短期疗效,但尚需大样本长期随访研究证实其在临床应用中的价值。肩锁关节脱位的治疗仍需进一步的研究,期望寻找一种既能解剖复位,获得持续性稳定,又能保证肩锁关节微动的治疗方法。 展开更多
关键词 肩锁关节 脱位 诊断 治疗 解剖重建 ENDOBUTTON 骨科植入物
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Stem cell therapy for Parkinson’s disease:safety and modeling 预览
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作者 Theo Stoddard-Bennett Renee Reijo Pera 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期36-40,共5页
For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fo... For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fortunately,sparked by the genetic revolution,stem cell reprogramming research and the advancing capabilities of personalization in medicine enable forward-thinking to unprecedented patient-specific modeling and cell therapies for Parkinson’s disease using induced pluripotent stem cells(iPSCs).In addition to modeling Parkinson’s disease more accurately than chemically-induced animal models,patient-specific stem cell lines can be created,elucidating the effects of genetic susceptibility and sub-populations’differing responses to in vitro treatments.Sourcing cell therapy with iPSC lines provides ethical advantages because these stem cell lines do not require the sacrifice of human zygotes and genetically-specific drug trails can be tested in vitro without lasting damage to patients.In hopes of finally slowing the progression of Parkinson’s disease or re-establishing function,iPSC lines can ultimately be corrected with gene therapy and used as cell sources for neural transplantation for Parkinson’s disease.With relatively localized neural degeneration,similar to spinal column injury,Parkinson’s disease presents a better candidacy for cell therapy when compared to other diffuse degeneration found in Alzheimer’s or Huntington’s Disease.Neurosurgical implantation of pluripotent cells poses the risk of an innate immune response and tumorigenesis.Precautions,therefore,must be taken to ensure cell line quality before transplantation.While cell quality can be quantified using a number of assays,a yielding a high percentage of therapeutically relevant dopaminergic neurons,minimal de novo genetic mutations,and standard chromosomal structure is of the utmost importance.Current techniques focus on iPSCs because they can be matched with donors using human leukocyte antigens,thereby reducing the sever 展开更多
关键词 alpha SYNUCLEIN animal model cell therapy DOPAMINERGIC neurons induced PLURIPOTENT STEM CELLS NEURODEGENERATION Parksinson’s disease STEM CELLS
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Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion 预览
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作者 Hyun-Kee Cho Woosuk Kim +4 位作者 Kwon-Young Lee Jin-Ok Ahn Jung Hoon Choi In Koo Hwang Jin-Young Chung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期162-168,共7页
Beta-nerve growth factor(β-NGF)is known to be a major leading cause of neuronal plasticity.To identify the possible action mechanisms ofβ-NGF gene therapy for sciatic nerve recovery,experimental dogs were randomly d... Beta-nerve growth factor(β-NGF)is known to be a major leading cause of neuronal plasticity.To identify the possible action mechanisms ofβ-NGF gene therapy for sciatic nerve recovery,experimental dogs were randomly divided into control,pyridoxine,and pyridoxine+β-NGF groups.We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining.The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal.In addition,we also investigated the effects ofβ-NGF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs.To accomplish this,tyrosine kinase receptor A(TrkA),βIII-tubulin and doublecortin(DCX)immunohistochemical staining was performed at 3 days after the last pyridoxine treatment.TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group,but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group.TrkA immunoreactivity in the dorsal root ganglia was similar betweenβ-NGF and control groups.The numbers ofβⅢ-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group.However,the reduction ofβⅢ-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in theβ-NGF group was significantly ameliorated than that in the pyridoxine group.These results indicate thatβ-NGF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increasing the TrkA and DCX levels in the dorsal root ganglia.The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC)of Seoul National University,South Korea(approval No.SNU-060623-1,SNU-091009-1)on June 23,2006 and October 9,2009,respectively. 展开更多
关键词 β-nerve growth factor βⅢ-tubulin DOUBLECORTIN gene therapy neuron-glial antigen 2 neuropathy PYRIDOXINE
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Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion 预览
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作者 Bei-Yao Gao Dong-Sheng Xu +6 位作者 Pei-Le Liu Ce Li Liang Du Yan Hua Jian Hu Jia-Yun Hou Yu-Long Bai 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1045-1057,共13页
Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.Ho... Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydrox 展开更多
关键词 brain-derived neurotrophic factor glutamate HIPPOCAMPUS m CIMT middle cerebral artery occlusion modified constraint-induced movement therapy α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor
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Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke 预览
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作者 Bei Zhang Kathryn ESaatman Lei Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期416-424,共9页
Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmace... Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke. 展开更多
关键词 cell death HERBAL compound immune response ISCHEMIC stroke therapy NEUROPLASTICITY NEUROPROTECTION oxidative damage traditional Chinese medicine
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Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage 预览
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作者 Rais Reskiawan Abdulkadir Mansour Alwjwaj +2 位作者 Othman Ahmad Othman Kamini Rakkar Ulvi Bayraktutan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1071-1078,共8页
Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can e... Breakdown of blood-brain barrier,formed mainly by brain microvascular endothelial cells(BMECs),represents the major cause of mortality during early phases of ischemic strokes.Hence,discovery of novel agents that can effectively replace dead or dying endothelial cells to restore blood-brain barrier integrity is of paramount importance in stroke medicine.Although endothelial progenitor cells(EPCs)represent one such agents,their rarity in peripheral blood severely limits their adequate isolation and therapeutic use for acute ischemic stroke which necessitate their ex vivo expansion and generate early EPCs and outgrowth endothelial cells(OECs)as a result.Functional analyses of these cells,in the present study,demonstrated that only OECs endocytosed DiI-labelled acetylated low-density lipoprotein and formed tubules on matrigel,prominent endothelial cell and angiogenesis markers,respectively.Further analyses by flow cytometry demonstrated that OECs expressed specific markers for sternness(CD34),immaturity(CD133)and endothelial cells(CD31)but not for hematopoietic cells(CD45).Like BMECs,OECs established an equally tight in vitro model of human BBB with astrocytes and pericytes,suggesting their capacity to form tight junctions.Ischemic injury mimicked by concurrent deprivation of oxygen and glucose(4 hours)or deprivation of oxygen and glucose followed by reperfusion(20 hours)affected both barrier integrity and function in a similar fashion as evidenced by decreases in transendothelial electrical resistance and increases in paracellular flux,respectively.Wound scratch assays comparing the vasculoreparative capacity of cells revealed that,compared to BMECs,OECs possessed a greater proliferative and directional migratory capacity.In a triple culture model of BBB established with astrocytes,pericytes and BMEC,exogenous addition of OECs effectively repaired the damage induced on endothelial layer in serum-free conditions.Taken together,these data demonstrate that OECs may effectively home to the site of vascular injury and re 展开更多
关键词 cell-based therapy endothelial progenitor cells ENDOTHELIUM ischemic stroke NEURODEGENERATION novel therapeutics outgrowth endothelial cells regenerative medicine stem cells translational medicine
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Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review 预览
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作者 Christoph Kolja Boese Philipp Lechler +3 位作者 Michael Frink Michael Hackl Peer Eysel Christian Ries 《世界临床病例杂志》 2019年第14期1825-1836,共12页
BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with imm... BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with immense socio-economic burden. One treatment aspect is parenteral antiinfective therapy, which usually requires an inpatient setting [Inpatient parenteral antibiotic therapy (IPAT)]. An alternative is outpatient parenteral treatment [Outpatient parenteral antibiotic therapy (OPAT)]. To conduct a health economic cost-benefit analysis of OPAT, a detailed cost analysis of IPAT and OPAT is required. So far, there is a lack of knowledge on the health economic effects of IPAT and OPAT for PPJI. AIM To review an economic comparison of IPAT and OPAT. METHODS A systematic literature review was performed through Medline following the PRISMA guidelines. RESULTS Of 619 identified studies, 174 included information of interest and 21 studies were included for quantitative analysis of OPAT and IPAT costs. Except for one study, all showed relevant cost savings for OPAT compared to IPAT. Costs for IPAT were between 1.10 to 17.34 times higher than those for OPAT. CONCLUSION There are only few reports on OPAT for PPJI. Detailed analyses to support economic or clinical guidelines are therefore limited. There is good clinical evidence supporting economic benefits of OPAT, but more high quality studies are needed for PPJI. 展开更多
关键词 Antibiotic THERAPY OUTPATIENT PARENTERAL antibiotic THERAPY INPATIENT PARENTERAL antibiotic THERAPY Cost analysis PERIPROSTHETIC joint infection PARENTERAL
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关注干眼的系统治疗方法 预览
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作者 晋秀明 章悦 《中华实验眼科杂志》 CAS CSCD 北大核心 2019年第3期218-223,共6页
干眼是多因素综合作用引起的眼表疾病,其特征是泪膜稳态失衡,眼表微环境改变,进而导致眼表的不适症状,其发病机制包括泪膜不稳定、泪液高渗透压、眼表炎症与损伤以及角膜神经感觉异常。干眼严重影响患者的工作和生活质量。随着科技的进... 干眼是多因素综合作用引起的眼表疾病,其特征是泪膜稳态失衡,眼表微环境改变,进而导致眼表的不适症状,其发病机制包括泪膜不稳定、泪液高渗透压、眼表炎症与损伤以及角膜神经感觉异常。干眼严重影响患者的工作和生活质量。随着科技的进步,干眼的治疗方法不断更新,轻中度干眼和重度干眼的治疗方法也有所不同。干眼治疗方法的选择因患者病情和治疗机构的条件而异,系统性、规范化、综合性的治疗可明显改善治疗效果。本文系统性总结了传统的与新兴的干眼治疗方法,这些方法操作简单,临床上切实可行,可为不同类型的干眼临床治疗提供参考。 展开更多
关键词 干眼 系统治疗 治疗结局 药物疗法 物理疗法 睑板腺功能障碍
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Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy
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作者 Xuehui Huang Funeng Xu +3 位作者 Huabo Hou Jianwen Hou Yi Wang Shaobing Zhou 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第6期1361-1370,共10页
As a minimally invasive local cancer therapy,photothermal therapy (PTT) has aroused intensive interests in recent years.However,the therapeutic effect of PTT is still unsatisfying due to the production of heat shock p... As a minimally invasive local cancer therapy,photothermal therapy (PTT) has aroused intensive interests in recent years.However,the therapeutic effect of PTT is still unsatisfying due to the production of heat shock proteins.Combination therapy has been regarded as a promising strategy to enhance therapeutic efficiency.In this study,a novel intelligent protoporphyrin (PplX)-based polymer nanoplatform is developed for synergistic enhancement of cancer treatment through combined PTT and nitric oxide (NO) therapy.The core of the nanoparticle is composed of closely packed porphyrin-based NO donors and PplX branches of the block copolymer.The prepared nanoparticles exhibit good photothermal conversion capability and high sensitivity to release NO under light illumination.And the produced high localized temperature and intracellular NO concentration could efficiently inhibit cancer cells both in vitro and in vivo.More important,this therapeutic nanoplatform can fundamentally eliminate the emergence of multidrug resistance and overcome the hypoxia microenvironment in tumors because of the absence of chemotherapeutic drugs and the oxygen-independent process,thus opening up new ideas for multifunctional therapeutic agent design for treatment of multidrug-resistant cancer. 展开更多
关键词 PHOTOTHERMAL THERAPY GAS THERAPY micelles combination THERAPY NANOCARRIER
1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕疗效研究 预览 被引量:1
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作者 宋婷 罗莉 +1 位作者 贾菲 高琳 《陕西医学杂志》 CAS 2019年第2期241-243,共3页
目的:评价1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕的临床疗效。方法:80例凹陷性痤疮瘢痕患者纳入本研究,其中观察组40例、对照组40例。1540nm非剥脱性点阵激光治疗后观察组患者应用水凝胶医用冷敷贴,对照组应用... 目的:评价1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕的临床疗效。方法:80例凹陷性痤疮瘢痕患者纳入本研究,其中观察组40例、对照组40例。1540nm非剥脱性点阵激光治疗后观察组患者应用水凝胶医用冷敷贴,对照组应用医用冰袋冷敷。分别对两组患者术后的瘢痕改善、视觉模拟评分(VAS)、疼痛持续时间、结痂时间、脱痂时间及完全愈合时间、不良反应等进行评价分析。结果:两组患者经过治疗后痤疮瘢痕均有不同程度改善,差异无统计学意义(P>0.05)。观察组患者术后VAS评分(2.48±1.15)分、疼痛持续时间(2.43±0.86)h、结痂时间(2.45±1.13)d、脱痂时间(5.20±1.01)d及完全愈合时间(8.50±1.24)d均短于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率明显低于对照组(P<0.05)。结论:1540nm非剥脱性点阵激光治疗凹陷性痤疮瘢痕后联合应用水凝胶医用冷敷贴,可以有效降低患者治疗后疼痛及灼烧感,缩短红斑持续时间及结脱痂时间,不良反应发生率低。 展开更多
关键词 寻常痤疮 瘢痕 治疗 激光疗法 水凝胶医用冷敷贴 疗效
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Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy 预览
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作者 Sadayuki Kawai Tadakazu Shimoda +4 位作者 Takashi Nakajima Masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第35期5334-5343,共10页
BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among patholog... BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histologi 展开更多
关键词 STOMACH NEOPLASM NEOADJUVANT THERAPY Drug THERAPY Pathology PROGNOSTIC factor
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Preoperative Short-Course Radiation Therapy in Rectal Cancer 预览
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作者 Pham Nguyen Tuong Pham Nguyen Cuong +2 位作者 Le Trong Hung Nguyen Thanh Ai Huynh Thanh Hai 《美中医学:英文版》 2019年第2期100-104,共5页
Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed... Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed preoperative short-course radiation therapy at Hue Central Hospital Vietnam between June 2016 and July 2018,using pelvic 3D-Conformal Radiation Therapy with the total radiation dose being 25 Gy in 5 fractions over five days.Results:Mean age 57.1±13.6 with 46.7%of patients in the range of 41-60 year-old.Male/female ratio:2/1.Tumour stage T3 and T4 was 70%and 30%,respectively;stage III and stage IV was 86.7%and 13.3%,respectively.Positive lymph node rates on endoscopic ultrasound were 85.7%in T3 and 77.8%in T4.Downstaging rate for stage III,T4 and T3 was 65.4%,65.4%and 4.8%,respectively.For upper third of the rectum:100%of T3 stage patients got no downstaging.For middle rectum:downstaging rate for stage III,T4 and T3 was 55.6%,57.1%and 7.1%,respectively.For lower rectum:downstaging rate for stage III,T4 was 50.0%and 100.0%,respectively.No acute toxicity was seen,86.7%of the patients performed laparoscopic sphincter-preserving surgery.Conclusion:For the treatment of locally advanced rectal cancer,neoadjuvant therapy is standard.Preoperative short-course radiation therapy is a reasonable therapeutic option because it demonstrates benefits in tumour downstaging especially for middle and lower rectum. 展开更多
关键词 Rectal cancer short-course RADIATION THERAPY PREOPERATIVE DOWNSTAGING pelvic 3D-conformal RADIATION therapy.
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Comparison of efficacy and safety between late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy for cervical cancer complicated with pelvic lymph node metastasis 预览
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作者 Yi Cheng Nan Huang +3 位作者 Jing Zhao Jianhua Wang Chen Gong Kai Qin 《肿瘤学与转化医学:英文版》 2019年第1期25-29,共5页
Objective This study aimed to compare and analyze the clinical efficacy and safety of late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy(IMRT) for cervical cancer complicated... Objective This study aimed to compare and analyze the clinical efficacy and safety of late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy(IMRT) for cervical cancer complicated with pelvic lymph node metastasis. Methods Sixty patients with cervical cancer complicated with pelvic lymph node metastasis who were admitted to our hospital from January 2013 to January 2015 were enrolled. The patients were randomly divided into the late-course dose-increasing IMRT group and the simultaneous integrated dose-increasing IMRT group, with 30 cases included in each group, respectively. All patients were concurrently treated with cisplatin. After treatment, the clinical outcomes of the two groups were compared. Results The remission rate of symptoms in the simultaneous integrated dose-increasing IMRT group was significantly higher than that in the late-course dose-increasing IMRT group(P < 0.05). The follow-up results showed that the overall survival time, progression-free survival time, and distant metastasis time of patients in the simultaneous integrated dose-increasing IMRT group were significantly longer than those in the late-course dose-increasing IMRT group(P < 0.05). The recurrent rate of lymph nodes in the radiation field in the simultaneous integrated dose-increasing IMRT group was significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in the incidence of cervical and vaginal recurrence and distant metastasis between the two groups(P > 0.05). The radiation doses of Dmax in the small intestine, D1 cc(the minimum dose to the 1 cc receiving the highest dose) in the bladder, and Dmax in the rectum in the simultaneous integrated dose-increasing IMRT group were significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in intestinal D2 cc(the minimum dose to the 2 cc receiving the highest dose) between the two groups(P > 0.05). The incidence of bone marrow suppr 展开更多
关键词 simultaneous integrated dose-increasing INTENSITY-MODULATED radiation therapy late-course dose-increasing INTENSITY-MODULATED radiation therapy cervical cancer COMPLICATED with pelvic lymph node metastasis clinical efficacy safety
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Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: A case report 预览
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作者 Si-Qi Zhang Kui-Jie Liu +5 位作者 Hong-Liang Yao San-Lin Lei Zhen-Dong Lei Wen-Jun Yi Li Xiong Hua Zhao 《世界临床病例杂志》 2019年第6期798-804,共7页
BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has b... BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has been reported that photodynamic therapy (PDT) as a remedial treatment for esophageal cancer. Colorectal cancer and esophageal cancer has many similarities, however, PDT as a salvage therapy for rectal cancer is rare. CASE SUMMARY Here, we describe a 56-year-old man who was admitted to the hospital due to a 6- mo history of hemafecia, which had been aggravated for 1 mo. Colonoscopy revealed a 3 × 4 cm ulcerated mass in the rectum 4 cm from the anus. Preoperative pathological examination showed villous adenoma, moderate-tohigh- grade dysplasia, good differentiation, and invasion of the mucosal muscle. The patient had R1 after ultra-low anterior resection, but he refused extended resection and experienced severe liver function impairment after 3 cycles of chemotherapy. Ultimately, the patient underwent PDT to remove R1. After five years of follow-up, there was no liver function impairment, recurrence, metastasis, sexual dysfunction, or abnormal defecation function. CONCLUSION This is the first case worldwide in which R1 of rectal cancer were successfully treated by PDT. 展开更多
关键词 Low RECTAL CANCER Photodynamic THERAPY Positive MICROSCOPIC distal margin SALVAGE THERAPY Removal RESIDUAL MICROSCOPIC CANCER Case report
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Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy
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作者 Yuanwen Zou Wei Zhang +7 位作者 Hongqiao Zhou Changhui Fu Longfei Tan Zhongbing Huang Xiangling Ren Jun Ren Xudong Chen Xianwei Meng 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第2期481-484,共4页
Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticanc... Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy. 展开更多
关键词 MICROWAVE thermal THERAPY ZIRCONIUM metal-organic framework NANOCUBES MICROWAVE SENSITIZER Tumor THERAPY BIOSAFETY
Traditional Chinese medicine five-tone therapy 预览
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作者 Haoran Zhang 《TMR生命研究》 2019年第2期80-83,共4页
From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-to... From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-tone therapy with Tibetan Singing bowl music therapy. The ancient music therapy is a kind of medical means which is oriented to the treatment effect. At first, it was mainly based on the music medical behavior of Taoist, and then gradually evolved into the modern treatment application of folk pentatonic therapy. On the basis of inheritance and development of ancient traditional music treatment, contemporary medicine proposed a new individualized music treatment. Therefore, the theory of five-tone therapy has updated the research on traditional Chinese music treatment theory and system, and will provide reference for the establishment of accurate music treatment system in the future. 展开更多
关键词 sound THERAPY music THERAPY TCM fiveelements FIVE TONES
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Does ‘super-responder’ patients to cardiac resynchronization therapy still have indications for neuro-hormonal antagonists? Evidence from long-term follow-up in a single center 预览
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作者 Yi-Ran HU Wei HUA +6 位作者 Han JIN Min GU Xiao-Han FAN Hong-Xia NIU Li-gang DING Jing WANG Shu ZHANG 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第3期251-258,共8页
Background Whether cardiac resynchronization therapy super-responders (CRT-SRs) still have indications for neuro-hormonal antagonists or not remains uninvestigated.Methods We reviewed clinical data from 376 patients w... Background Whether cardiac resynchronization therapy super-responders (CRT-SRs) still have indications for neuro-hormonal antagonists or not remains uninvestigated.Methods We reviewed clinical data from 376 patients who underwent CRT implantation in Fuwai Hospital from 2009 to 2015 and followed up to 2017.CRT-SRs were defined by an improvement of the New York Heart Association functional class and left ventricular ejection fraction to ≥ 50% in absolute values at 6-month follow-up.All CRT-SRs were assigned into two groups on the basis of whether persistently receiving neuro-hormonal antagonists (NHA)(defined as angiotensin-converting enzyme inhibitors/ angiotensin receptor blockers and β-blockers) after 6-month follow-up and then we compared long-term outcome.Results A total of 60 patients met criteria for super-response.One of thirteen (7.7%) CRT-SRs without NHA had all-cause death,which also occurred in 2 of 47 (4.3%) in CRT-SRs with NHA (P = 0.526).However,3 of 13 (23.1%) CRT-SRs without NHA had heart failure (HF) hospitalization,1 of 47 (2.1%) CRT-SRs with NHA had this endpoint (P = 0.040).Besides,subgroup analysis indicated that,for ischemic etiology group,CRT-SRs receiving NHA had considerably lower incidence of HF hospitalization than those without NHA (0 vs.75%,P = 0.014),which was not observed in non-ischemic etiology group (2.6% vs.0,P = 1.000) during long-term follow-up.Conclusions Our study found that for ischemic etiology,compared with CRT-SRs with NHA,CRT-SRs without NHA were associated with a higher risk of HF hospitalization.However,for non-ischemic etiology,we found that CRT-SRs with NHA or without NHA at follow-up were associated with similar outcomes,which needed further investigation by prospective trials. 展开更多
关键词 Cardiac RESYNCHRONIZATION THERAPY Heart failure Super-responder Optimal medical THERAPY
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