基金This work was supported by the grants from the Shanghai Munici- pal Commission of Health and Family Planning （No. 20174Y0004 to Y.P.）, Applied Basic Research Key Project of Yunnan （No. 2015FA027 to L.R.）, the National Natural Science Foundation of China （Nos. U1602221 and 31771516 to C.C., and No. 81672624 to F.J.）, the Shanghai Health System Outstanding Academic Leader Training Program （No. XBR2013114 to F.J.）, and the Guangdong Medicine Research Fund （No. B2018201 to C.Z.）.