基金We would like to thank Yun Li and Mengjie Chen at University of North Carolina and bioinformatic core facility at Peking University for their help in imputation analysis and helpful suggestions of this study. Part of the analysis is performed on the Computing Platform of the Center for Life Sciences of Peking University. This work was supported by CAMS Innovation Fund for Medical Sciences （Grant No. 2016-12M-4-002 awarded to CW） and the National Key R＆D Program （Grant No. 2016YFC1302701 to CW and Grant No. 2016YFC0901603 to GG）.