基金The authors would like to thank Constanze Kloβ for providing excellent technical assistance and performing the semen analysis, Ivan Hoffmann, Dr, Petra Kaltwager, and Dr. Solveig Koller are thanked for the recruitment of participants for this study. The study was sponsored in part by a grant from the Wilhelm-Roux program of the Medical Faculty of the Martin Luther University Halle-Wittenberg to TG （FKZ 25/43）. The funding source played no role in the study design and data evaluation.
基金Project supported by the National Natural Science Foundation of China（Grant Nos.61771067,61631014,61471051,and 61401036） the Youth Research and Innovation Program of Beijing University of Posts and Telecommunications,China（Grant Nos.2015RC12 and 2017RC10）
基金This study was funded by the Deutsche Krebshilfe （Grant No. 111450）. COSYCONET was financially supported by the Competence Network Asthma/COPD that is funded by the German Federal Ministry of Education and Research （Grant No. FKZ 01GI1001）, as well as by unrestricted grants from a consortium of pharmaceutical companies including Astra Zeneca GmbH, Bayer Schering, Pharma AG, Boehringer Ingelheim Pharma GmbH ＆ Co. KG, Chiesi GmbH, GlaxoSmithKline, Grifols Deutschland GmbH, MSD Sharp ＆ Dohme GmbH, Mundipharma GmbH, Novartis Deutschland GmbH, Pfizer Pharma GmbH, and Takeda Pharma Vertrieb GmbH ＆ Co. KG of Germany. Hummingbird Diagnostics from Germany contributed to the microarray measurements.