Background:Resting heart rate(RHR)is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients.Bisoprolol fumarate,a second-generation beta-adrenoreceptor bl...Background:Resting heart rate(RHR)is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients.Bisoprolol fumarate,a second-generation beta-adrenoreceptor blockers(β-blocker)is commonly prescribed drug to manage hypertension.The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease(CAD)patients from the CAD treated with bisoprolol(BISO-CAD)study who had comorbid hypertension.Methods::We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study(n=866),which was a phase IV,multination,multi-center,single-arm,observational study carried out from October 2011 to July 2015 across China,South Korea,and Vietnam.Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome(CCCO),the results were presented as adjusted odds ratio(OR)along with 95%confidence interval(CI)and adjusted P value.Results::A total of 681 patients(mean age:64.77±10.33 years)with hypertension from BISO-CAD study were included in the analysis.Bisoprolol improved CCCOs in CAD patients with comorbid hypertension,with RHR<65 and<70 beats/min compared with RHR≥65 and≥75 beats/min,respectively,in the efficacy analysis(EA)set.In addition,it lowered RHR in both intent-to-treat(ITT)and EA groups after 6,12,and 18 months of treatment.Further,RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients(adjusted OR:4.34;95%CI:1.19-15.89;P=0.03).Also,events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR<69 beats/min in ITT patients.Conclusion::Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence,improve CCCO without affecting their blood pressure.展开更多
目的探讨曲美他嗪联合比索洛尔治疗缺血性心肌病患者的临床效果以及对患者氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)和心功能等指标产生的影响作用。方法将海口市第三人民医院自2016年1月-2018年10月...目的探讨曲美他嗪联合比索洛尔治疗缺血性心肌病患者的临床效果以及对患者氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)和心功能等指标产生的影响作用。方法将海口市第三人民医院自2016年1月-2018年10月间收治的缺血性心肌病患者86例作为研究对象,随机数字表法分为比索洛尔治疗的对照组和曲美他嗪联合比索洛尔治疗的研究组各43例,分别治疗3个月后观察2组患者心功能各项指标和NT-proBNP水平变化情况。结果研究组患者临床总有效率为90.70%,明显高于对照组的74.42%(P<0.05);治疗后2组患者LVEDd和LVESd水平均明显降低,LVEF水平明显升高,其中研究组各项指标改善情况均显著优于对照组,组间差异具有统计学意义(均P<0.05);治疗后2组患者NT-proBNP水平均明显降低,其中研究组降低程度明显优于对照组,组间差异具有统计学意义(P<0.05)。结论曲美他嗪联合比索洛尔治疗缺血性心肌病能够明显改善患者心功能各项指标,降低NT-proBNP水平,提高临床治疗的总有效率,值得推广使用。展开更多
基金This study was funded by Merck Serono Co.,Ltd,an affiliate of Merck KGaA,Darmstadt,Germany.
文摘Background:Resting heart rate(RHR)is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients.Bisoprolol fumarate,a second-generation beta-adrenoreceptor blockers(β-blocker)is commonly prescribed drug to manage hypertension.The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease(CAD)patients from the CAD treated with bisoprolol(BISO-CAD)study who had comorbid hypertension.Methods::We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study(n=866),which was a phase IV,multination,multi-center,single-arm,observational study carried out from October 2011 to July 2015 across China,South Korea,and Vietnam.Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome(CCCO),the results were presented as adjusted odds ratio(OR)along with 95%confidence interval(CI)and adjusted P value.Results::A total of 681 patients(mean age:64.77±10.33 years)with hypertension from BISO-CAD study were included in the analysis.Bisoprolol improved CCCOs in CAD patients with comorbid hypertension,with RHR<65 and<70 beats/min compared with RHR≥65 and≥75 beats/min,respectively,in the efficacy analysis(EA)set.In addition,it lowered RHR in both intent-to-treat(ITT)and EA groups after 6,12,and 18 months of treatment.Further,RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients(adjusted OR:4.34;95%CI:1.19-15.89;P=0.03).Also,events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR<69 beats/min in ITT patients.Conclusion::Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence,improve CCCO without affecting their blood pressure.
文摘目的探讨曲美他嗪联合比索洛尔治疗缺血性心肌病患者的临床效果以及对患者氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)和心功能等指标产生的影响作用。方法将海口市第三人民医院自2016年1月-2018年10月间收治的缺血性心肌病患者86例作为研究对象,随机数字表法分为比索洛尔治疗的对照组和曲美他嗪联合比索洛尔治疗的研究组各43例,分别治疗3个月后观察2组患者心功能各项指标和NT-proBNP水平变化情况。结果研究组患者临床总有效率为90.70%,明显高于对照组的74.42%(P<0.05);治疗后2组患者LVEDd和LVESd水平均明显降低,LVEF水平明显升高,其中研究组各项指标改善情况均显著优于对照组,组间差异具有统计学意义(均P<0.05);治疗后2组患者NT-proBNP水平均明显降低,其中研究组降低程度明显优于对照组,组间差异具有统计学意义(P<0.05)。结论曲美他嗪联合比索洛尔治疗缺血性心肌病能够明显改善患者心功能各项指标,降低NT-proBNP水平,提高临床治疗的总有效率,值得推广使用。