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Histo-Epidemiological Profile of Head and Neck Cancers in Benin 认领
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作者 Spero H. Raoul Hounkpatin Luc Valere C. Brun +5 位作者 Marie-Claire Balle Fatiou Alabi Bouraima Tire Abdias Bossou Nicolas H. Amegan Marius Claude Flatin Marie-Therese Akélé-Akpo 《耳鼻喉(英文)》 2020年第1期19-29,共11页
Background: The collection of data on cancers is essential to assess their importance in a population and plan control strategies. In Benin as in many sub-Saharan Africa countries, cancer data are often not well infor... Background: The collection of data on cancers is essential to assess their importance in a population and plan control strategies. In Benin as in many sub-Saharan Africa countries, cancer data are often not well informed. Purpose: To study the epidemiological and anatomopathological profiles of head and neck cancers. Methods: This was a descriptive cross-sectional study of head and neck cancers in Benin from January 2009 to 31 December 2014. These tumours were collected in the registers of the 5 anatomy-pathological laboratories in Benin as well as in that of the only hospital in the country that sends its requests for histological examination abroad. Results: During the period, 611 cases of head and neck tumour were reported, including 298 malignant cases, or 48.8%. The average age was 45.3 ± 18.7 years (extremes: 1 year and 91 years) with a maximum of cases between 50 and 60 years (19.1%). The sex ratio was 1.2. The cancers occurred mainly in the pharynx (27.9%), the oral cavity (19.8%), the nose, sinuses and jaws (18.1%), the thyroid (12.8%), the salivary glands (8.7%) and the larynx (8.4%). They were of epithelial origin in 79.5% of cases, mainly squamous cell carcinomas (50.3%) and lymphomas in 12.8% of cases. Conclusion: Head and neck cancer is preventable. A special place should be given to the fight against cancer in Benin. Strategies to prevent and manage these cancers cannot be put in place without accurate data collection. 展开更多
关键词 CANCER of the HEAD and NECK Squamous Cell Carcinoma of the HEAD and NECK CANCER of the Mouth CANCER of the LARYNX
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Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test 认领
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作者 Noel Pin-Vieito María J Iglesias +13 位作者 David Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-Moranta Victoriaálvarez-Sánchez Fernando Fernández-Ba?ares Jaume Boadas Eva Martínez-Bauer Rafael Campo Luis Bujanda ángel Ferrandez Virginia Pi?ol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第1期70-85,共16页
BACKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)detection.Nevertheless,some conditions could theoretically favour blood originating in proximal a... BACKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)detection.Nevertheless,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without CRC.METHODS Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion detection.Ambulatory patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete colonoscopy.Patients without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the research.We determined the cumulative risk of GIC,CRC and upper GIC.Hazard rate(HR)was calculated adjusted by age,sex and presence of significant colonic lesion.RESULTS We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/gr.During a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to CRC.FIT-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An upper GIC was detected in 22(0.8%)patients 展开更多
关键词 COLONOSCOPY Colorectal CANCER FAECAL immunochemical TEST Gastric CANCER GASTROESOPHAGEAL CANCER Gastrointestinal CANCER Symptoms
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Cancer/testis antigen,Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers 认领
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作者 Akiko Shida Takashi Fukuyama +8 位作者 Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe Yoshihito Takahashi 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第4期424-432,共9页
BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk... BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODS We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors.The levels of serum PG I/PG II and IgG against H.pylori were measured.According to their serological status,the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients,63(81.8%)expressed KK-LC-1.The IgG titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/H.pylori infection(+)]was as high as 93.9%high.KK-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H.pylori infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC. 展开更多
关键词 Gastric CANCER Tumor ANTIGEN Cancer/testis ANTIGEN Kita–Kyushu lung CANCER antigen-1 Helicobacter pylori Early detection of CANCER
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Precision medicine for gastrointestinal cancer:Recent progress and future perspective 认领
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作者 Tasuku Matsuoka Masakazu Yashiro 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第1期1-20,共20页
Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate worldwide.Despite significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is cha... Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate worldwide.Despite significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal prognosis.There is an urgent need for new diagnostic and therapeutic approaches.Recent technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI cancer.Here we review the application and status of precision medicine in GI cancer.Analyses of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with malignancy.With the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI cancer.Although the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted drugs.These progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine. 展开更多
关键词 GASTROINTESTINAL CANCER ESOPHAGEAL CANCER Gastric CANCER Colorectal CANCER PRECISION MEDICINE Liquid BIOPSY Gene panel PRECISION surgery Biomarkers
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Information Needs of Breast Cancer Patients at Cancer Diseases Hospital, Lusaka, Zambia 认领
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作者 Beauty Lilala Namushi Marjorie Kabinga Makukula Patricia Katowa Mukwato 《乳腺癌(英文)》 2020年第2期34-53,共20页
Background: Breast cancer is the second most common cancer worldwide and the second most common among Zambian women. Breast cancer diagnosis being a stressful experience, causes psychological and emotional disruption ... Background: Breast cancer is the second most common cancer worldwide and the second most common among Zambian women. Breast cancer diagnosis being a stressful experience, causes psychological and emotional disruption that can be abated by meeting information needs of the affected patients. In light of the escalating cases of Breast cancer among the Zambian women, the study examined a special aspect of cancer management which is usually neglected in most cases. Aim: The main objective of the study was to assess information needs of breast cancer patients at the Cancer Diseases Hospital in Lusaka, Zambia using a modified structured interview schedule adopted from the Toronto Information Needs Questionnaire-Breast Cancer (TINQ-BC). Methods: A descriptive cross-sectional design was used to elicit the information needs of breast cancer patients. One hundred and ten (97% response rate) participants were selected using simple random sampling method and data was collected using a modified structured interview schedule adopted from the Toronto Information Needs Questionnaire-Breast Cancer (TINQ-BC). Stata 10.0 (StataCorp, 2008) was employed for all quantitative data analysis and graphical presentation of data. Results: The overall score for information needs was obtained by adding the scores across all the five information needs categories which were further divided into three categories namely: low important scores, of less than 50%, moderately important scores of 50% - 70% and highly important scores ranged above 70% of the 200 total scores. Out of the 110 participants recruited, 88 (80%) indicated that the information across the five categories was moderately important. Logistic regression of information needs and posited determinants revealed that anxiety levels;education level;presence of co-morbidity;and being on treatment were significant determinants of patients’ informational needs (Effect’s p ≤ 0.05). Conclusion: The findings of this study support the idea that breast cancer patients are seeking more infor 展开更多
关键词 Information Needs BREAST CANCER BREAST CANCER PATIENTS
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Challenges Facing Women Caring for a Spouse Having Cancer Treatment: A Critical Literature Review 认领
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作者 Patience Mbozi Cathy Ratcliff Dave Roberts 《护理学期刊(英文)》 2020年第1期34-68,共35页
Introduction: Cancer affects patients and families, especially female spouses. Female carers are affected emotionally, psychologically, spiritually and physically. Challenges while caring for husbands with cancer incl... Introduction: Cancer affects patients and families, especially female spouses. Female carers are affected emotionally, psychologically, spiritually and physically. Challenges while caring for husbands with cancer include: higher stress;poorer health-related quality of life;emotional strain;impaired immune system;low appetite;high blood pressure;depression and anxiety. Female spousal carers also experience satisfaction that they rendered appropriate care to their spouse. Aim: To analyse challenges facing women caring for a spouse on cancer treatment. Method: Systematic critical literature review through CASP. Thematic analysis of data. Results: 16 studies met the inclusion criteria;12 were selected by critical analysis. 4 themes emerged: “Quality of marital relationship”, “Effective communication”, “Carers” burden and need for support’, and “Coordination of care among providers”. Discussion: 4 themes are discussed in detail and related to literature outside the review. Conclusion: Women caring for a spouse on cancer treatment is affected by the cancer, symptoms, hospital admission and caring. They withhold information from their spouse to protect him. They have poor quality of life and poor health. HCP rarely recognize their role or needs. 展开更多
关键词 Female CARERS CHALLENGES Men with CANCER CANCER
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Immunotherapy – new perspective in lung cancer 认领
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作者 Fillipe Dantas Pinheiro Adriano Fernandes Teixeira +3 位作者 Breno Bittencourt de Brito Filipe Antonio Franca da Silva Maria Luísa Cordeiro Santos Fabrício Freire de Melo 《世界临床肿瘤学杂志:英文版》 CAS 2020年第5期250-259,共10页
Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer death.It is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung cance... Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer death.It is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung cancer.However,such malignancy has been increasingly subdivided into histological and molecular subtypes to guide treatment.Therapies can be used in adjuvant and palliative settings.Regarding immunotherapy,it has been widely tested in both first or subsequent palliative lines.In this sense,drugs such as pembrolizumab,nivolumab,atezolizumab,ipilimumab,avelumab,and durvalumab have been assessed in large studies.Some of these trials have also studied these medicines in adjuvant and in maintenance therapy.In recent years,advances in immunotherapy have raised the hope that the unfavorable prognosis observed in several affected individuals can be changed.Immunotherapy has increased the overall survival in squamous NSCLC,non-squamous NSCLC,and small cell lung cancer.However,it has added to the oncology practice some side effects that are unusual in standard chemotherapy and require special clinical support.In order to show how immunotherapy is being applied in the treatment of lung carcinoma,we reviewed the main studies in adjuvant and palliative scenarios.What is the better scheme?What is the better combination?What is the better dose?When should we use immunotherapy?Does programmed cell death ligand 1 expression significantly interfere in immunotherapy efficiency?Some of these questions have already been answered,while others require more investigations. 展开更多
关键词 Lung cancer Treatment IMMUNOTHERAPY Squamous non-small cell lung cancer Non-squamous non-small cell lung cancer Small cell lung cancer
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Update on oral and oropharyngeal cancer staging-International perspectives 认领
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作者 Masanari G.Kato Chung-Hwan Baek +6 位作者 Pankaj Chaturvedi Richard Gallagher Luiz P.Kowalski C.Rene Leemans Saman Warnakulasuriya Shaun A.Nguyen Terry A.Day 《世界耳鼻咽喉头颈外科杂志(英文)》 2020年第1期66-75,共10页
Squamous cell carcinoma of the oral cavity and oropharynx have been used synonymously and interchangeably in the world literature in the context of head and neck cancers.As the 21st century progresses,divergence betwe... Squamous cell carcinoma of the oral cavity and oropharynx have been used synonymously and interchangeably in the world literature in the context of head and neck cancers.As the 21st century progresses,divergence between the two have become more evident,particularly due to evidence related to human papillomavirus-associated oropharyngeal squamous cell carcinoma.As such,the American Joint Committee on Cancer recently published the 8th edition Cancer Staging Manual,serving as a continued global resource to clinicians and researchers.Through changes in staging related to T and N clinical and pathologic classifications,the new system is expected to influence current management guidelines of these cancers that have distinct anatomic and etiopathogenic characteristics.This article aims to review such impactful changes in a time of critical transition of the staging of head and neck cancer and how these changes may affect clinicians and researchers worldwide. 展开更多
关键词 Oral cancer Oropharyngeal cancer Cancer staging AJCC Human papillomavirus Head and neck cancer management
Prevalence of Various Cancer-Related Risk Factors among the Forcibly Displaced Myanmar National Community, the Rohingya, in Bangladesh: A Preliminary Assessment 认领
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作者 Rumana Dowla Annekathryn Goodman Sadia Akter 《癌症治疗(英文)》 2020年第5期251-264,共14页
Background: Large numbers of Forcibly Displaced Myanmar Nationals (FDMN), also called the Rohingya community, in Bangladesh face chronic life-threatening illnesses. Symptoms concerning for a cancer diagnosis are not e... Background: Large numbers of Forcibly Displaced Myanmar Nationals (FDMN), also called the Rohingya community, in Bangladesh face chronic life-threatening illnesses. Symptoms concerning for a cancer diagnosis are not easily evaluated and treated by healthcare systems available to this population. We conducted a rapid needs assessment of cancer screening and pain and palliative care with the goal of identifying the prevalence of cancer risk factors among the Rohingya who attended local health facilities. Methods: A cross-sectional study was conducted in the Kutupalong camp of Ukhiya, Cox’s Bazar among the Rohingya community. Data were?collected through purposive sampling. Face-to-face interviews were done using a structured questionnaire. Statistics were analyzed by using IBM SPSS 23.?Results: Out of 85 participants, 75 were female and 10 were male. 70 (82.4%) were uneducated (defined as lacking any formal institutional education), 10 (11.8%) people completed the primary level education and only 5 (5.9%) people received secondary level education. There were many participants with pulmonary disease with 35 (41.2%) people endorsing a history of asthma, bronchitis, and/or tuberculosis. There was a lack of female menstrual sanitation and hygiene with only 25 (29.4%) patients using sanitary napkins, that were donated by Non Government Organizations. Only 5.9% of the women had received any form of cervical cancer screening.?Conclusion: This study identifies risk factors associated with cancers and life-limiting diseases among the FDMN Rohingya refugees in Bangladesh. It is necessary to develop targeted education, cancer screening and cancer awareness programs for this population. 展开更多
关键词 CANCER Risk Factors for CANCER Life-Limiting Illness PALLIATIVE Care FDMN (Forcibly DISPLACED Myanmar National) Rohingya MENSTRUAL Hygiene Pulmonary Disease Cox’s Bazar BANGLADESH
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One size does not fit all for pancreatic cancers: A review on rare histologies and therapeutic approaches 认领
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作者 Monica Niger Michele Prisciandaro +13 位作者 Maria Antista Melissa Anna Teresa Monica Laura Cattaneo Natalie Prinzi Sara Manglaviti Federico Nichetti Marta Brambilla Martina Torchio Francesca Corti Sara Pusceddu Jorgelina Coppa Vincenzo Mazzaferro Filippo de Braud Maria Di Bartolomeo 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第8期833-849,共17页
Exocrine pancreatic neoplasms represent up to 95%of pancreatic cancers(PCs)and are widely recognized among the most lethal solid cancers,with a very poor 5-year survival rate of 5%-10%.The remaining<5%of PCs are ne... Exocrine pancreatic neoplasms represent up to 95%of pancreatic cancers(PCs)and are widely recognized among the most lethal solid cancers,with a very poor 5-year survival rate of 5%-10%.The remaining<5%of PCs are neuroendocrine tumors that are usually characterized by a better prognosis,with a median overall survival of 3.6 years.The most common type of PC is pancreatic ductal adenocarcinoma(PDAC),which accounts for roughly 85%of all exocrine PCs.However up to 10%of exocrine PCs have rare histotypes,which are still poorly understood.These subtypes can be distinguished from PDAC in terms of pathology,imaging,clinical presentation and prognosis.Additionally,due to their rarity,any knowledge regarding these specific histotypes is mostly based on case reports and a small series of retrospective analyses.Therefore,treatment strategies are generally deduced from those used for PDAC,even if these patients are often excluded or not clearly represented in clinical trials for PDAC.For these reasons,it is essential to collect as much information as possible on the management of PC,as assimilating it with PDAC may lead to the potential mistreatment of these patients.Here,we report the most significant literature regarding the epidemiology,typical presentation,possible treatment strategies,and prognosis of the most relevant histotypes among rare PCs. 展开更多
关键词 Rare pancreatic cancers Pancreatic acinar cell cancer Pancreatic adenosquamous cancer Undifferentiated pancreatic cancer Pancreatoblastoma Pseudopapillary pancreatic cancer
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Molecular modulation of autophagy: New venture to target resistant cancer stem cells 认领
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作者 Harpreet K Mandhair Miroslav Arambasic +1 位作者 Urban Novak Ramin Radpour 《世界干细胞杂志:英文版(电子版)》 SCIE CAS 2020年第5期303-322,共20页
Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates d... Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis. 展开更多
关键词 AUTOPHAGY Cancer stem cells Cancer cells Cancer therapy Therapeutic resistance Cancer metastasis
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Urban Rural Disparity in Westernization Related Cancers and the Increasing Incidence in Parallel with Socioeconomic Development and Urbanization from 2000-2015 among a Rural Chinese Population: An Observational Study 认领
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作者 Denggui Wen Hongtao He +4 位作者 Yuetong Chen Kohei Akazawa Yunjiang Liu Cuizhi Geng Bao’en Shan 《健康(英文)》 2020年第5期456-473,共18页
Abstract China used to have great urban rural disparity in socioeconomic development. Since the late 1980s, rapid socioeconomic development and urbanization have been taking place in rural settings. It is epidemiologi... Abstract China used to have great urban rural disparity in socioeconomic development. Since the late 1980s, rapid socioeconomic development and urbanization have been taking place in rural settings. It is epidemiologically established that cancer scale and profile will transit as economy prospers and urbanization develops. However, there are few published studies reporting what changes are undergoing in cancer pattern in Chinese rural settings. Population-based tumor registration data collected by us in urban Shijiazhuang city (available for 2,374,827 people in 2012) and in rural Shexian County (available for 408,995 people since 2000) were used for urban rural comparison of age standardized incidence rate (ASIR) of westernization-related cancers in 2012, and the trend of biennial ASIR of these cancers for 2000-2015 in Shexian County was examined following a decade of rapid socioeconomic development and urbanization. From 1988-2015, the Gross Domestic Product per Capita (GDP) in rural Shexian County increased from 860 to 3000 US$, and urbanization rate from 22.4% to 54.8%. The biennial ASIRs of lung, colorectal, gallbladder cancer and leukemia in both sexes, and that of breast, ovary, thyroid, and kidney cancer in women increased significantly from 2000 - 2015. The increase from 2000-2001 to 2014-2015 in man and women for lung cancer was from 15.9 to 34.7 per 105 (P = 0.05) and 9.6 to 16.7 (P = 0.00), for colorectal cancer from 6.6 to 15.9 (P = 0.00) and 4.0 to 11.7 (P = 0.00), for gallbladder cancer from 0.1 to 2.4 (P = 0.00) and 0.3 to 2.7 (P = 0.00), for leukemia from 2.8 to 7.7 (P = 0.00) and 2.3 to 6.2 (P = 0.00);and in women for cancer of breast from 2.8 to 17.3 (P = 0.00), kidney from 0.2 to 2.4 (P = 0.00), ovary from 0.2 to 4.3 (P = 0.00), and thyroid from 0.2 to 4.2 (P = 0.00). Notwithstanding these increases, their ASIRs in 2012 in Shexian County were still significantly lower than that in Shijiazhuang city. Westernization-related cancer is increasing rapidly in rural China. Comprehensive measures are n 展开更多
关键词 Urban-Rural DISPARITY In WESTERNIZATION RELATED CANCER Population Based Tumor Registration SOCIOECONOMIC Development URBANIZATION WESTERNIZATION RELATED CANCER
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Expression and significance of mi R-654-5p and mi R-376b-3p in patients with colon cancer 认领
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作者 Ping Li Jia-Xun Cai +4 位作者 Fei Han Jie Wang Jia-Jie Zhou Kai-Wen Shen Liu-Hua Wang 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第4期492-502,共11页
BACKGROUND The relationship between micro RNAs,such as miR-654-5 p and miR-376 b-3 p,and the prognosis of colon cancer has not been studied until now.AIM To evaluate the expression levels of miR-654-5 p and miR-376 b-... BACKGROUND The relationship between micro RNAs,such as miR-654-5 p and miR-376 b-3 p,and the prognosis of colon cancer has not been studied until now.AIM To evaluate the expression levels of miR-654-5 p and miR-376 b-3 p and their clinical significance in colon cancer.METHODS RT-q PCR was performed to evaluate miR-654-5 p and miR-376 b-3 p expression in34 pairs of colon cancer and adjacent noncancerous tissues.Subsequently,the association of miR-654-5 p and miR-376 b-3 p expression with clinical factors or the survival of patients suffering from colon cancer was determined by using The Cancer Genome Atlas.RESULTS miR-654-5 p was upregulated and miR-376 b-3 p was downregulated in colon cancer tissues compared with adjacent noncancerous tissues(P<0.001).Increased miR-654-5 p and decreased miR-376 b-3 p expression levels weresignificantly associated with metastasis and clinical stage.Moreover,a univariate analysis demonstrated that colon cancer patients with high miR-654-5 p or low miR-376 b-3 p expression(P=0.044 and 0.007,respectively)had a poor overall survival rate.A multivariate analysis identified high miR-654-5 p expression and low miR-376 b-3 p expression as independent predictors of poor survival in colon cancer patients.CONCLUSION Upregulated miR-654-5 p and downregulated miR-376 b-3 p may be associated with tumour progression in colon cancer,and these micro RNAs may serve as independent prognostic markers for colon cancer. 展开更多
关键词 Colorectal CANCER COLON CANCER RECTAL CANCER MiR-654-3p MiR-376b-5p Prognosis Survival The CANCER Genome Atlas
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Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective 认领
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作者 Beatrice Aramini Valentina Masciale Khawaja Husnain Haider 《世界干细胞杂志:英文版(电子版)》 SCIE CAS 2020年第6期406-421,共16页
Since the first publication regarding the existence of stem cells in cancer[cancer stem cells(CSCs)]in 1994,many studies have been published providing in-depth information about their biology and function.This researc... Since the first publication regarding the existence of stem cells in cancer[cancer stem cells(CSCs)]in 1994,many studies have been published providing in-depth information about their biology and function.This research has paved the way in terms of appreciating the role of CSCs in tumour aggressiveness,progression,recurrence and resistance to cancer therapy.Targeting CSCs for cancer therapy has still not progressed to a sufficient degree,particularly in terms of exploring the mechanism of dynamic interconversion between CSCs and non-CSCs.Besides the CSC scenario,the problem of cancer dissemination has been analyzed indepth with the identification and isolation of microRNAs(miRs),which are now considered to be compelling molecular markers in the diagnosis and prognosis of tumours in general and specifically in patients with non-small cell lung cancer.Paracrine release of miRs via“exosomes”(small membrane vesicles(30-100 nm),the derivation of which lies in the luminal membranes of multi-vesicular bodies)released by fusion with the cell membrane is gaining popularity.Whether exosomes play a significant role in maintaining a dynamic equilibrium state between CSCs and non-CSCs and their mechanism of activity is as yet unknown.Future studies on CSC-related exosomes will provide new perspectives for precision-targeted treatment strategies. 展开更多
关键词 Cancer Cancer stem cells EXOSOMES Lungs MIRNA MICROVESICLES Nonsmall cell lung cancer
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Interaction between LCSCs and lung cancer microenvironment and TCM intervention 认领
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作者 Xiao-Di Liu Shan-Qi Guo +2 位作者 Rui-Yu Mou Ming-Xin Wu Xiao-Jiang Li 《肿瘤微环境研究》 2020年第1期16-22,共7页
Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung canc... Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung cancer in the last decade,actually there is no substantial breakthrough for the 5-year survival rate of patients has no significant improvement and is still below 15%.Plenty of evidence suggests that malignant tumors including lung cancer have a unique subgroup of cells featured with self-renewal and multidirectional differentiation potential.Cancer stem cells(CSCs)are the root of tumor growth and metastasis,and the characteristic changes of malignant phenotype(such as recurrence,invasion and metastasis,and drug resistance)are closely linked with CSCs.This paper explored the possible correlated mechanism of the complex interaction between lung cancer stem cells(LCSCs)and lung cancer microenvironment,to provide ideas for the R&D of relevant treatment technologies,the promotion of the progress in traditional medical technology,and the breakthrough of the bottleneck of long-term effect of lung cancer. 展开更多
关键词 LUNG CANCER LUNG CANCER stem cells LUNG CANCER MICROENVIRONMENT
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Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies 认领
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作者 Jian-Nan Li Wei Li +2 位作者 Lan-Qing Cao Ning Liu Kai Zhang 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第4期365-382,共18页
Mesenchymal stem cells(MSCs),which are a kind of stem cell,possess an immune privileged nature,tumour homing features,and multi-lineage differentiation ability.MSCs have been studied in many fields,such as tissue engi... Mesenchymal stem cells(MSCs),which are a kind of stem cell,possess an immune privileged nature,tumour homing features,and multi-lineage differentiation ability.MSCs have been studied in many fields,such as tissue engineering,nervous system diseases,and cancer treatment.In recent years,an increasing number of researchers have focused on the effects of MSCs on various kinds of tumours.However,the concrete anticancer efficacy of MSCs is still controversial.Gastrointestinal(GI)malignancies are the major causes of cancerrelated death worldwide.The interactions of MSCs and GI cancer cells in specific conditions have attracted increasing attention.In this review,we introduce the characteristics of MSCs and analyse the effects of MSCs on GI malignancies,including gastric cancer,hepatoma,pancreatic cancer,and colorectal cancer.In addition,we also provide our perspectives on why MSCs may play different roles in GI malignancies and further research directions to increase the treatment efficacy of MSCs on GI malignancies. 展开更多
关键词 MESENCHYMAL stem cells GASTROINTESTINAL MALIGNANCIES Gastric CANCER HEPATOMA PANCREATIC CANCER Colorectal CANCER
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西黄丸抗癌机制的网络药理学研究 认领
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作者 庄振杰 王雅萱 +4 位作者 朱若辰 林挺 张严 谢静怡 刘展华 《中药新药与临床药理》 CAS CSCD 北大核心 2020年第7期823-831,共9页
目的基于网络药理学方法探讨西黄丸抗癌的潜在作用机制。方法经BATMAN数据库获取西黄丸的潜在活性成分及作用靶点。经DisGeNET数据库与OMIM数据库检索获取癌症疾病的相关靶点。使用Drugbank数据库获取癌症疾病的潜在治疗靶点。采用R软... 目的基于网络药理学方法探讨西黄丸抗癌的潜在作用机制。方法经BATMAN数据库获取西黄丸的潜在活性成分及作用靶点。经DisGeNET数据库与OMIM数据库检索获取癌症疾病的相关靶点。使用Drugbank数据库获取癌症疾病的潜在治疗靶点。采用R软件对药物和疾病靶点进行匹配映射。使用String数据库构建关键靶点蛋白质互作网络,使用DAVID数据库对关键靶点行生物信息学注释,并使用R软件及Cytoscape软件进行绘图可视化。结果通过筛选得到西黄丸44个主要活性成分,共有1908个作用靶点,其中与癌症疾病靶点有关的活性成分为19个,其关键靶点涉及的相关癌种包括前列腺癌、胰腺癌、子宫内膜癌等。西黄丸可通过作用于ESR1、EGFR、SRC等靶蛋白,调节雌激素信号通路、催乳激素信号通路及ErbB信号通路等信号通路而发挥抗癌的治疗作用。结论西黄丸对癌症的治疗潜在治疗作用体现了其多成分、多靶点、多途径的药理学特点。调节癌细胞分化、抑制癌细胞增殖及血管生成、靶向雌激素受体及通路可能是其抗癌治疗的重要药效基础。 展开更多
关键词 西黄丸 癌症 网络药理学 癌细胞分化 癌细胞增殖
Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis 认领
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作者 Henry Y.Jiang Sara Najmeh +16 位作者 Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2020年第3期187-201,共15页
While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its ... While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. 展开更多
关键词 NOD1 iE-DAP ML130 colon CANCER METASTASIS cancer-extracellular matrix adhesion CANCER migration p38 MAPK ACTIVATION intravital microscopy survival analysis
Metabolomics profile in gastrointestinal cancers:Update and future perspectives 认领
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作者 Giulia Nannini Gaia Meoni +1 位作者 Amedeo Amedei Leonardo Tenori 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第20期2514-2532,共19页
Despite recent progress in diagnosis and therapy,gastrointestinal(GI)cancers remain one of the most important causes of death with a poor prognosis due to late diagnosis.Serum tumor markers and detection of occult blo... Despite recent progress in diagnosis and therapy,gastrointestinal(GI)cancers remain one of the most important causes of death with a poor prognosis due to late diagnosis.Serum tumor markers and detection of occult blood in the stool are the current tests used in the clinic of GI cancers;however,these tests are not useful as diagnostic screening since they have low specificity and low sensitivity.Considering that one of the hallmarks of cancer is dysregulated metabolism and metabolomics is an optimal approach to illustrate the metabolic mechanisms that belong to living systems,is now clear that this-omics could open a new way to study cancer.In the last years,nuclear magnetic resonance(NMR)metabolomics has demonstrated to be an optimal approach for diseases’diagnosis nevertheless a few studies focus on the NMR capability to find new biomarkers for early diagnosis of GI cancers.For these reasons in this review,we will give an update on the status of NMR metabolomic studies for the diagnosis and development of GI cancers using biological fluids. 展开更多
关键词 Metabolomics Nuclear magnetic resonance spectroscopy Pancreatic cancer Gastric cancer Colorectal cancer Biological fluids
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Assessing Efficient Risk Ratios: An Application to Surgical Stage Prediction in Cervical Cancer 认领
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作者 Jean C. Jesang Collins O. Odhiambo 《统计学期刊(英文)》 2020年第2期274-302,共29页
Background:?Cervical cancer remains the second most commonly diagnosed cancer and the third leading cause of cancer death in developing countries. Improving clinicians’ knowledge and understanding of surgical staging... Background:?Cervical cancer remains the second most commonly diagnosed cancer and the third leading cause of cancer death in developing countries. Improving clinicians’ knowledge and understanding of surgical staging is critical?in the fight against the disease. However, a systematic evaluation of different ordinal regression models based on diverse predicted outcomes has not been given its due share in literature.?Objective:?To systematically assess the flexibility of odds ratios for three popular ordinal regression models i.e.?the Multinomial Logistic (ML) model, the Continuation Ratio (CR) model and Adjacent Category Logistic (ACL) model when applying cervical cancer data in surgical stage prediction.?Method:?We systematically, compared the performance of CR, ML and the ACL as the predictive mechanisms, and evaluate the most appropriate model in the cervical cancer setting. The study considered women who visited the Oncology department at the Moi Teaching and Referral Hospital’s Chandaria Cancer and Chronic Diseases Center and were diagnosed and surgically treated for cervical cancer from January 2014?to December 2018.?Results and Conclusion:?We presented the comparison between?3?different regression models for ordinal data within the cervical cancer setting. We found that the CR model without proportional odds yielded better results?comparing Akaike Information Criterion (AIC), log likelihood ratio and residual deviance. In addition, the key prognostic factor associated with invasive cervical cancer was the (International Federation of Gynecology and Obstetrics) FIGO clinical stage which in particular, had a higher influence on the surgical Stage 2 outcomes compared to the lesser surgical stage categories. All the 5?independent features selected for classifying the patients into surgical stages were the FIGO clinical stage and partly, the presence or absence of?symptomatic vaginal discharge. 展开更多
关键词 SURGICAL STAGE ORDINAL Regression Cervical Cancer Odds Ratio PREDICTIVE VARIABLES
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