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Hepatoprotective effect of Premna corymbosa(Burm.f.) Rottl.& Willd.leaves extract on CCl_4 induced hepatic damage in Wistar albino rats
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作者 Karthikeyan M Deepa K 《亚太热带医药杂志:英文版》 SCIE 2010年第1期17-20,共4页
【正】Objective:To investigate the hepetoprotective activity of Premna corymbosa leaves against carbon tetrachloride(CCl<sub>4</sub>) induced hepatic damage.Methods:Hepatotoxicity was induced in wistar ... 【正】Objective:To investigate the hepetoprotective activity of Premna corymbosa leaves against carbon tetrachloride(CCl<sub>4</sub>) induced hepatic damage.Methods:Hepatotoxicity was induced in wistar rats of both sexes by intraperitoneal injection of CCl<sub>4</sub>,1 mL/kg body weight for every 72 h.The ethanolic extract of Premna corymbosa leaves were administrated at doses of 200 & 400 mL/kg body weight, p.o.,daily for 14 days.The hepatotoxicity and its prevention was assessed by serum markers like serum alkaline phosphatase(SALP),serum triglycerides(STG),serum total protein(STP), serum cholesterol(SC),and liver wet weight and histopathological studies of the liver.Results:In treatment with the ethanolic extract,the toxic effect of CCl<sub>4</sub> was controlled significantly(P【0.01) by restoration of the levels of biochemical parameters as compared to normal and standard drug silymarin treated groups.The liver weight was reduced by the ethanolic extract treated groups. The histopathology of the liver sections evidenced the hepatoprotective activity.Conclusion:The ethanolic extract of the leaves of Premna corymbosa possess significant acute hepatoprotective activity.Premna corymbosa can be recommended for the liver disorders. 展开更多
关键词 Premna corymbosa LEAVES Ethanolic EXTRACT CCl4-induced liver damage HEPATOPROTECTIVE effect
Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl4-induced chronic liver damage in rats 预览 被引量:2
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作者 Yun-Kyoung Yim Hyun Lee +4 位作者 Kwon-Eui Hong Young-Il Kim Byung-Ryul Lee Tae-Han Kim Ji-Young Yi 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2006年第14期2245-2249,共5页
瞄准:在老鼠在导致 CCl4 的长期的肝损坏上在 Yanglingquan (GB34 ) 调查用手的针灸的 hepatoprotective 效果。方法:老鼠与 CCl4 (1 mL/kg ) intraperitoneally 被注射并且与用手的针灸使用对待一个星期为 10 wk 在左 GB34 (Yangling... 瞄准:在老鼠在导致 CCl4 的长期的肝损坏上在 Yanglingquan (GB34 ) 调查用手的针灸的 hepatoprotective 效果。方法:老鼠与 CCl4 (1 mL/kg ) intraperitoneally 被注射并且与用手的针灸使用对待一个星期为 10 wk 在左 GB34 (Yanglingquan ) 增强操作技术 3 次。在左臀的区域的 non-acupoint 作为一个假冒的点被选择。到 hepatoprotective 在 GB34 用手的针灸完成的估计,胆固醇,组织学的分析和血房间数的肝索引,包括浆液中高音的生物化学的试金,著名计算机生产厂商,高山和总数的测量被进行。结果:当与控制相比组和假冒的针灸组织,在 GB34 的用手的针灸减少了肝索引,浆液中高音,著名计算机生产厂商,高山和全部的胆固醇层次。它也增加了并且使正常化白血球和淋巴细胞的人口。结论:有在左 GB34 增强操作技术的用手的针灸减少肝毒性,保护肝功能和肝织物,并且使在使喝醉 CCl4 的老鼠的有免疫力的活动正常化。 展开更多
关键词 针灸治疗 穴位 肝损伤 保护作用
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