期刊文献+
共找到102,112篇文章
< 1 2 250 >
每页显示 20 50 100
Social Cultural and Economic Factors Affecting the Practice of Secondary Prevention among Patients with Type 2 Diabetes Mellitus at Consolata Nkubu and Meru Level Five Hospital in Meru County 认领
1
作者 Dennis Mugambi Ngari Annastacia Munzi Mbisi Teresia Wanjiru Njogu 《临床诊断学期刊(英文)》 2020年第1期1-17,共17页
Diabetes is chronic metabolic disorder characterized by states of hyperglycemia with disturbances of carbohydrates, fat and protein metabolism. Diabetes affects millions of people globally every day and the prevalence... Diabetes is chronic metabolic disorder characterized by states of hyperglycemia with disturbances of carbohydrates, fat and protein metabolism. Diabetes affects millions of people globally every day and the prevalence of the disease is on the rise due to unhealthy diet and lifestyle. The disorder usually results to chronic complications including cardiovascular diseases, diabetic nephropathy, diabetic neuropathy, foot ulcers and diabetic eye diseases that are all preventable through secondary preventive measures. Once an individual has been diagnosed with T2DM, secondary preventive approaches are essential in preventing the occurrence of chronic complications. However, lack of awareness of these measures has been cited as the common reasons for the development of complications. The study aimed to assess the effect of social cultural and economic factors on the practice of secondary diabetes prevention among patients with Type 2 Diabetes Mellitus (T2DM) at Consolata Hospital Nkubu and Meru Level Five Hospital between March and April 2019. A descriptive correlational study design was adopted to collect data from 357 purposively sampled participants with T2DM using questionnaires and Focus Group Discussion Guide. Quantitative data were analyzed using SPSS version 25 at 95% confidence interval and a significance level p ≤ 0.05. Most respondents attended Meru Teaching and Referral Hospital. Majority of the respondents were aged between 40 - 60 years. Most respondents 31.6% had secondary level of education and majority 67% was employed. Concerning secondary prevention, majority did foot examination on every visit 70.6% and BP monitoring 69.5% while 56.5% did annual eye screening. Level of income, affordability of services, health insurance cover of the patients, monthly cost of DM management and traditional beliefs in managing DM all significantly influenced DM secondary prevention at a p value ≤ 0.05. The factors need to be addressed to reduce the global burden posed by the disease. 展开更多
关键词 Type 2 Diabetes MELLITUS Secondary Prevention Economic FACTORS CULTURAL FACTORS Chronic COMPLICATIONS
在线阅读 下载PDF
Digestive Pathologies during Chronic Renal Failure in the Nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali 认领
2
作者 Magara Samaké Seydou Sy +11 位作者 Hamadoun Yattara Moctar Coulibaly Mamadou Badou Sanogo Aboubacar Sidiki Fofana Aboudou Messoum Dolo Djénéba Maiga Djénéba Diallo Atabieme Kodio Bakary Diarra Karamoko Djiguiba Djibril Sy Saharé Fongoro 《临床诊断学期刊(英文)》 2020年第1期41-48,共8页
Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the preva... Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was 48 ± 14 years with extremes of 15 and 84 years. The sample consisted of 59.2% men versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%). Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which 47.4% were monitored by hemodialysis. Hepatitis C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV (7.5%). Endoscopic examinations were represented by fibroscopy (84.5%), rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%). Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions were observed at anuscopy. Conclusion: The prevalence of these digestive manifestations and the endoscopic lesions encountered indicate the importance of digestive endoscopy and the performance of hepatic serologies in chronic renal failure patients with digestive symptoms and/or treated by hemodi 展开更多
关键词 Chronic Renal Failure DIGESTIVE Signs MALI
在线阅读 下载PDF
体外热电场治疗在男性慢性盆腔疼痛综合征中的应用 认领
3
作者 丁虹璐 冯经纬 +6 位作者 吴珍 陈嘉良 刘柏隆 林志钧 谢俊聪 许源城 周祥福 《中华腔镜泌尿外科杂志:电子版》 2020年第1期56-60,共5页
目的从多方面评估体外热电场治疗对男性慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)患者症状的改善情况并进行疗效分析,进而判断其临床应用价值。方法回顾性收集2018年4月至2019年3月,57例使用LR-2005体外热电场治疗机进行治疗的CP/CPPS... 目的从多方面评估体外热电场治疗对男性慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)患者症状的改善情况并进行疗效分析,进而判断其临床应用价值。方法回顾性收集2018年4月至2019年3月,57例使用LR-2005体外热电场治疗机进行治疗的CP/CPPS患者的临床资料,并对其治疗前后所填评分量表进行统计学分析。患者20~50岁,病程3个月~7年,其中行1个疗程治疗17例,2个疗程32例,3个疗程8例。所用评分量表包括:NIH-CPSI评分、PUF评分、VAS评分、QOL评分、SAS评分、SDS评分等。结果治疗前与治疗后,患者NIH-CPSI总评分分别为(25.05±6.32)vs(19.54±6.16)、PUF症状评分为(10.86±4.41)vs(8.46±4.11)、PUF困扰评分为(5.35±2.88)vs(4.03±2.33)、VAS评分为(3.97±2.40)vs(2.03±1.85)、QOL评分为(4.89±1.27)vs(3.95±1.25)、SAS评分为(37.35±8.76)vs(34.00±8.14)、SDS评分为(34.41±7.43)vs(32.05±4.78),治疗后均下降且与治疗前比较差异具有显著统计学意义(P<0.01)。治疗后NIHCPSI评分轻中度人数增加,重度人数明显减少,治疗前后差异具有显著统计学意义(P<0.01)。患者治疗后未见特殊不适或不良反应发生。结论体外热电场治疗能够有效减轻CP/CPPS患者炎症和疼痛反应,改善排尿症状,降低焦虑抑郁程度,提高患者生活质量。其临床疗效显著,治疗有效率高,符合WHO倡导的“无痛、无创、非介入”的治疗模式,患者容易接受,值得临床推广。 展开更多
关键词 体外热电场治疗 CP/CPPS 慢性 盆腔疼痛综合征 慢性 前列腺炎
在线阅读 下载PDF
Non-Communicable Chronic Diseases and Structural Indicators in an Epidemiological Transition Country 认领
4
作者 Natalia Romero-Sandoval S. Ramiro Canelos +3 位作者 Héctor Javier Sánchez-Pérez Ricardo Romero Fernando Cornejo Miguel Martín-Mateo 《流行病学期刊(英文)》 2020年第1期32-42,共11页
Objective: To determine associations between standardized prevalence ratios of Metabolic Syndrome (MS), High Blood Pressure (HBP), and Obesity (O) with structural factors in ecuadorian population aged 20 to 59. Method... Objective: To determine associations between standardized prevalence ratios of Metabolic Syndrome (MS), High Blood Pressure (HBP), and Obesity (O) with structural factors in ecuadorian population aged 20 to 59. Methods: An ecological study was conducted through data from the Ecuador’s National Health and Nutrition Survey 2013-2014, and National Census. Standardized prevalence ratio (SPR) variability was analyzed with Poisson multiple regression models (adjusted Relative Risk). Results: The SPR variability for the three diseases was associated with non-affiliation to social security, and inversely related to lower urbanization. HBP and O were associated with functional illiteracy and higher rates of primary care physicians/1000 inhabitants. HBP and MS were related to poor housing. Conclusions: Policies of non-communicable chronic diseases control in ecological transition countries need to take structural variations into account. 展开更多
关键词 Chronic Illness SOCIAL INEQUALITY STATISTICAL Analysis Policy Process Ecuador
在线阅读 下载PDF
Cutaneous Abnormalities in Chronic Kidney Disease Patients with and without Dialysis 认领
5
作者 Md. Obaidur Rahman Muhammad Rafiqul Alam +4 位作者 Asia Khanam Md. Rezaul Alam Md. Kabir Hossain A. K. M. Shahidur Rahman Fahmida Haque 《生物科学与医学(英文)》 2020年第1期64-76,共13页
Background: Chronic kidney disease (CKD) is increasingly prevalent worldwide. CKD may present with different cutaneous manifestations. Objectives: To evaluate the dermatological manifestations and compare these manife... Background: Chronic kidney disease (CKD) is increasingly prevalent worldwide. CKD may present with different cutaneous manifestations. Objectives: To evaluate the dermatological manifestations and compare these manifestations between patients with maintenance hemodialysis (MHD) and non-dialysis groups. Methods: It was a cross sectional study conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from April 2013 to March 2014. A total of 150 hospital admitted CKD patients were evaluated for dermatological manifestations. Age, gender, haemoglobin level, 24-hours urinary total protein (UTP), serum creatinine, serum fasting lipid profile, estimated glomerular filtration rate (e-GFR) and dermatological manifestations of the study subjects were recorded accordingly. Inter-group comparisons were made between patients with and those without cutaneous abnormality. Results: Out of 150 study subjects, 99 (66%) were male and 51 (34%) were female, 69 (46%) patients were on MHD and 81 (54%) patients were without dialysis, their mean (±SD) age was 44.6 ± 12.3 year. A Total of 126 (84%) patients had cutaneous abnormalities;among them 69 (54.76%) were pre-dialytic and 57 (45.24%) were on MHD group. The mean (±SD) serum creatinine was relatively higher but haemoglobin level was significantly lower (p = 0.021), while UTP was significantly higher (p = 0.038) among patients with cutaneous abnormality. There was no relationship between lipid profile with cutaneous abnormality. Among 126 (84%) patients with cutaneous abnormality;pallor was the most common cutaneous abnormality (72%) followed by xerosis (68.66%), pruritus (65.33%), half and half nails (38.66%), pigmentation (33.33%), purpura/ecchymosis (16.66%), fungal infection (16%), ulcerative stomatitis (10.66%) and bacterial infection (10%). Pigmentation (52.6%), purpura (35.1%), ulcerative stomatitis (21.1%) and bacterial infection (19.3%) were significantly higher in MHD group. Among 69 (54.76%) predialytic patients;11 展开更多
关键词 Chronic Kidney Disease (CKD) CUTANEOUS MANIFESTATIONS Maintenance HEMODIALYSIS (MHD)
在线阅读 免费下载
Cerebral Localization of Chronic Lymphocytic Leukemia Simulating Progressive Multifocal Leukoencephalopathy: The Lessons from a Case 认领
6
作者 T. M. Sandouno S. Chebrek +10 位作者 C. Tchonko G. Pichancourt L. Giovannetti H. Zerazhi Romain Appay H. Lepidi H. Bachir S. Hamaz H. B. Alaoui K. Serraj B. Slama 《临床医学病理报告(英文)》 2020年第4期96-106,共11页
Background: Central neurological involvement is the most frequent extra hematological manifestation of chronic lymphocytic leukemia;it is multifactorial and rarely due to a cerebral localization of the disease. We rep... Background: Central neurological involvement is the most frequent extra hematological manifestation of chronic lymphocytic leukemia;it is multifactorial and rarely due to a cerebral localization of the disease. We report a case of cerebral localization of chronic lymphoid leukemia whose clinical and radiological aspects were very suggestive of progressive multifocal leukoencephalopathy. Case Presentation: A 65-year-old patient who was HIV-negative (human immunodeficiency virus), had consulted for bilateral axillary, cervical and inguinal lymphadenopathy associated with major asthenia and hyper lymphocytosis (lymphocyte count was 11 giga/l). Chronic lymphocyticleukemia with TP53 mutation was diagnosed and treatment with Ibrutinib 420 mg/day was initiated. After 2 months of treatment, the evolution was marked by the onset of neurological disorders whose clinical-radiological presentation and temporal evolution had led to the diagnosis of progressive multifocal leukoencephalopathy. In the absence of virological evidence in the cerebrospinal fluid analysis, a stereotactic biopsy of the brain lesions had been performed, making it possible to formally rule out this infectious hypothesis and to demonstrate cerebral invasion by tumour cells. Immuno-chemotherapy combining Rituximab-Cyclophosphamide-Doxorubicin-Vincristine-Prednisone-Ibrutinib (RCHOP-Ibrutinib) with intrathecal chemotherapy resulted in a very good clinical-radiological response. Conclusion: The appearance of neurological manifestations in the context of chronic lymphocytic leukemia must systematically lead to a search for a cerebral localization of the disease. In the absence of virological evidence in the cerebrospinal fluid, any suspicion of progressive multifocal leukoencephalopathy in this context should lead to the histological study of brain lesions. 展开更多
关键词 Progressive MULTIFOCAL LEUKOENCEPHALOPATHY Chronic LYMPHOCYTIC LEUKEMIA John Cunningham Virus CEREBRAL LOCALIZATION Ibrutinib
在线阅读 免费下载
The Prevalence and Determinants of Stunting among Children 6 - 59 Months of Age in One of the Sub-Counties in the Rwenzori Sub-Region, Western Uganda 认领
7
作者 Enos Mirembe Masereka Arthur Kiconco +1 位作者 Edson Katsomyo Clement Munguiko 《护理学期刊(英文)》 2020年第3期239-251,共13页
Introduction: Despite being referred to as one of the country’s “food baskets”, 41% of children, 6 - 59 months of age in the Rwenzori sub-region, Western Uganda are stunted. Stunting is a form of chronic malnutriti... Introduction: Despite being referred to as one of the country’s “food baskets”, 41% of children, 6 - 59 months of age in the Rwenzori sub-region, Western Uganda are stunted. Stunting is a form of chronic malnutrition in which children are short for their age. In this study, we established the prevalence and determinants of stunting in one of the sub-counties in this region. Methods: This was a cross-sectional descriptive study conducted in one of the sub-counties in the Rwenzori sub-region, Western Uganda from May 26th to June 26th, 2018. A total of 372 mothers and their children were recruited using systematic sampling. Data was collected using a questionnaire. Stunting was determined by taking child’s height or length and comparing it with child’s age. A child whose height or length for age index was less than &#8722;2 Standard Deviations (SD) was considered stunted. We used descriptive statistics to understand characteristics of mothers and multivariable logistic regression model to obtain the determinants of stunting. Data was analyzed using SPSS version 20. Results: A total of 372 mothers and their children were included in this study;majority, 307 (83.0%) of the children were 6 - 24 months old and nearly half, 167 (44.9%) were stunted. We found that reserving food stock for use in the dry season (aOR = 0.23, CI = 0.08 - 0.62, p = 0.004), deworming children (aOR = 0.32, CI = 0.18 - 0.54, p = 0.001) and the family earning at least 10,000 Ushs (2.7USD) at the end of the month (aOR = 0.36, CI = 0.22 - 0.58, P = 0.001) were associated with no stunting. Conclusions: We found a high prevalence of stunting among children 6 - 59 months of age. We recommend enforcing ownership of food granary by households especially during dry season, support to de-worming programs targeting children below five years of age and establishing community based income generating livelihood projects. 展开更多
关键词 Determinants STUNTING Chronic MALNUTRITION CHILDREN WESTERN Uganda
在线阅读 免费下载
Chronic Effusive Pericarditis and Chronic Constrictive Pericarditis 认领
8
作者 C.Richard Conti 《Cardiovascular Innovations and Applications》 2020年第2期291-293,共3页
Chronic Pericarditis is infl ammation that begins gradually,is long lasting and results in fl uid accumulation in the pericardial space or thickening of the pericardium.The etiology is unknown but may be cancer,TB or ... Chronic Pericarditis is infl ammation that begins gradually,is long lasting and results in fl uid accumulation in the pericardial space or thickening of the pericardium.The etiology is unknown but may be cancer,TB or hypothyroidism.Arrhythmias are common and seen in almost half the patients.The commonest arrhythmia is atrial fi brillation.Symptoms and signs are related to increased right atrial pressure and physical fi ndings include elevated JVP and pericardial knock.Non surgical therapy consists mainly of no salt.Surgery cures about 85%of patients,however 5–15%of patients will die.Chronic effusive pericarditis occurs when there is persistent restriction of the visceral pericardium after pericardiocentesis. 展开更多
关键词 chronic constrictive pericarditis chronic effusive pericarditis PERICARDITIS surgical treatment
在线阅读 免费下载
The Therapeutic Role of Guided Mental Imagery in Treating Stress and Insomnia: A Neuropsychological Perspective 认领
9
作者 Ravinder Jerath Connor Beveridge +1 位作者 Michael Jensen Ruchir Paladiya 《医学心理学(英文)》 2020年第1期21-39,共19页
Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmace... Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmaceutical treatments can be addictive, detrimental to health, and in the case of insomnia don’t produce naturalistic sleep. We present a viewpoint on a potential adjunctive treatment of distress and insomnia that harnesses specific mental imagery as a component of mind/body relaxation technique. Via our perspective on the modern nature of stress and insomnia, our theoretical perspective on how specific guided mental imagery can be used to treat these ailments, and our review on the current literature on treatment with mental imagery, we hope to stimulate further research into mental health treatment with mental imagery which has traditionally been neglected. This perspective on the pathology of insomnia and distress is founded in prevailing “dysevolution” and hyper-arousal theories. Hyper-arousal is characterized in part by a vicious cycle of chronic physiological and emotional stimulation/distress. We argue for spatially based mental imagery in the form of nighttime-sky imagery to attenuate such pathology by breaking one away from a vicious cycle of stimulation and distress and discuss neuropsychological bases for its potential treatment mechanisms which include the autonomic nervous system and a phenomenal foundation of conscious cognition. 展开更多
关键词 MENTAL IMAGERY GUIDED IMAGERY INSOMNIA Chronic STRESS HYPERAROUSAL Vicious Cycle
在线阅读 免费下载
Effect of Non-Surgical Periodontal Therapy on the Severity of Rheumatoid Arthritis—A Clinical and Hematological Study 认领
10
作者 Rujuta Krishnakant Pandya Monali Amit Shah Yesha Hareshkumar Raval 《口腔学期刊(英文)》 2020年第1期1-9,共9页
Background: The epidemiological and pathological relations between Periodontitis and Rheumatoid arthritis (RA) have been stated. The citrullination and attendant autoantibody responses are defining features of RA. It ... Background: The epidemiological and pathological relations between Periodontitis and Rheumatoid arthritis (RA) have been stated. The citrullination and attendant autoantibody responses are defining features of RA. It has been recognized that the oral bacteria, inflammation and its mediators might play an important role in RA activity. Hence this study aimed to evaluate the effect of Non-surgical Periodontal Therapy in reducing the severity of Rheumatoid arthritis. Materials and Method: Totally 25 participants diagnosed with RA and Periodontitis were included in the study. Clinical parameters such as CPSS index, BOP% and CAL, estimation of ESR and calculation of DAS28 done at baseline, after Pre-NSPT and after next Post-NSPT were recorded. Results: Statistically significant improvement was noted for CPSS (p < 0.001), BOP% (p < 0.001) and CAL (p < 0.001) after NSPT. The ESR values also showed significant reductions (p < 0.001) and the DAS28 scores also showed statistically significant improvements (p Conclusion: Reduction in the periodontal inflammation positively affects the rheumatoid arthritis activity, hence improving the patient’s health. 展开更多
关键词 Chronic PERIODONTITIS RHEUMATOID ARTHRITIS DAS28
在线阅读 免费下载
Anticonvulsants for Preventing Seizures in Patients with Chronic Subdural Haematoma: Pilot Study 认领
11
作者 Mohamed Adel Ghoneim Waleed Abbass 《现代神经外科学进展(英文)》 2020年第2期237-243,共7页
Introduction: There is increasing of the incidence of chronic subdural hematomas (CSDH), due to increase of the elderly population with increase of intake oral anticoagulation and antiplatelet drugs in this category o... Introduction: There is increasing of the incidence of chronic subdural hematomas (CSDH), due to increase of the elderly population with increase of intake oral anticoagulation and antiplatelet drugs in this category of patients. Seizures occur as a complication in 2.3% to 20.4% of the patients. There is a considerable side effect associated with using of anti-epileptic drugs (AEDs). Aim of the Study: To rule the value of prophylactic antiepileptic drugs in prevention of seizures after surgical evacuation of chronic subdural hematoma. Methods: A prospective controlled non-randomized study was performed on 26 patients with chronic or subacute subdural hematoma that was surgically evacuated through burr-holes from April 2017 to June 2019. We divided the patients into 2 groups: group A patients received prophylactic antiepileptic drugs for 6 month and group B patients didn’t receive prophylactic antiepileptic drugs and the 2 groups were observed to detect occurrence of post-operative seizures for 6-month follow-up after surgery. Medical history, demographic data and imaging characteristics were recorded. Results: Seizure prevalence for all patients during hospitalization and 6-month follow-up was zero among the 13 patients who received prophylactic anti-seizure medications, and was 1 (7.7%) among the 13 patients who didn’t receive prophylactic anti-seizure medications. Conclusions: The incidence of post-operative seizures in patients with chronic subdural hematoma operated upon by burr holes evacuation is low. The administration of prophylactic antiepileptic drugs decreases the incidence of seizures after evacuation of CSDH, but the difference was not significant. So prophylactic antiepileptic drugs should not be routinely given for all patients with CSDH operated upon by burr hole evacuation unless there is risk factor for seizure development. 展开更多
关键词 CHRONIC SUBDURAL HEMATOMA SEIZURE PROPHYLAXIS
在线阅读 免费下载
Effect of Angiotensin Receptor-Neprilysin Inhibitor versus Valsartan on Cardiac Status in Patients with Chronic Heart Failure with Reduced Ejection Fraction: A Randomized Clinical Trial in Rangpur Medical College Hospital, Bangladesh 认领
12
作者 Shakil Ghafur Md. Abu Zahid +4 位作者 Haripada Sarkar Rabindra Nath Barman Abdullah Al-Mahmud Mahbubur Rahman Hasanul Islam 《内科学期刊(英文)》 2020年第1期21-34,共14页
Background: Heart failure with reduced ejection fraction has a significant association with considerable morbidity and mortality, but there is still inadequacy in appropriate treatment to prevent this condition. We ob... Background: Heart failure with reduced ejection fraction has a significant association with considerable morbidity and mortality, but there is still inadequacy in appropriate treatment to prevent this condition. We observed the effect of angiotensin receptor neprilysin inhibitor (ARNi) with such disorder compared to valsartan. Methods: In this single-blind trial, the patients were enrolled with chronic HF aged on or above 40 years, symptomatic NYHA class II - IV, an elevated NT-proBNP above 400 pg/ml level and a reduced LVEF of 40% or less. The patients were randomly assigned 1:1 to the treatment arms either ARNi (50 mg titrated to 100 mg twice a day) or valsartan (40 mg titrated to 80 mg twice a day) and followed for a median of 88 days. The primary outcome was mode of cardiovascular death and re-hospitalization for heart failure. Changes in the level of NT-proBNP and rate of ejection fraction were also measured. Results: Cardiovascular deaths occurred 4 (8%) in the ARNi treatment arm, while 11 (22%) in the valsartan treatment arm with significant hazard ratio in the ARNi group [Hazard Ratio = 0.37;95% CI: 0.34, 0.64;p = 0.042] during a median of 88 days of follow up period and 2 (4%) of the patients from the ARNi treatment arm were hospitalized due to HF, while in the valsartan treatment arm, 10 (20%) patients were hospitalized due to HF followed by receiving treatment respectively with hazard ratio in the ARNi group [Hazard Ratio = 0.80;95% CI: 0.57, 0.92;p Conclusion: Chronic treatment with the angiotensin receptor neprilysin inhibitor (ARNi) strongly decreases the NT-proBNP as well as morbidity and mortality and increases LVEF in patients with heart failure compared to valsartan. 展开更多
关键词 Chronic Heart Failure Ejection Fraction Angiotensin Receptor-Neprilysin INHIBITOR (ARNi) NT-proBNP
在线阅读 免费下载
Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C 认领
13
作者 Sudeep Tanwar Freya Rhodes +2 位作者 Ankur Srivastava Paul M Trembling William M Rosenberg 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第2期109-133,共25页
At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to ... At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. 展开更多
关键词 LIVER INFLAMMATION FIBROSIS Cirrhosis Non-alcoholic fatty LIVER DISEASE CHRONIC hepatitis C CHRONIC LIVER DISEASE Anti-fibrotic Biomarker
在线阅读 免费下载
Evaluation of Access to Care for Patients with Chronic Kidney Disease Not on Dialysis in Saint-Louis Region (SENEGAL) 认领
14
作者 Seck Sidy Mohamed Doupa Dominique +5 位作者 Ndongo Modou Ahoui Seraphin Diop-Dia Amadou Dia Diatou Gueye Ngouampa Blaise Magloire Enguerran Macia 《肾脏病(英文)》 2020年第1期1-10,共10页
Introduction: Patients with chronic diseases, especially kidney diseases, frequently use the health care system and free dialysis policies are being implemented in many countries in Africa. This study aimed to evaluat... Introduction: Patients with chronic diseases, especially kidney diseases, frequently use the health care system and free dialysis policies are being implemented in many countries in Africa. This study aimed to evaluate access to care for patients with chronic kidney disease (CKD) in northern region of Saint-Louis. Methodology: In a cross-sectional survey, we included non-dialyzed CKD patients aged ≥20 years who attended outpatient nephrology clinic at University Hospital of Saint-Louis between January 1st and January 31st 2018. Access to care was measured using a questionnaire that integrated dimensions such as availability, geographic and financial accessibility, convenience, acceptability, effectiveness of care and quality of information. Socio-demographic and clinical data were also collected and analyzed with Epi Info 7. Results: Among 97 surveyed patients, 90 were included (response rate of 92.8%). Patients’ mean age was 35.2 years (20 - 89 years) and 55% were male. Only 30% of patients had health coverage either by the government, or private insurance or community health insurance. Access to care was rated as globally low by 73% of participants. However, we noticed some variations according to dimensions of access. Geographical accessibility and convenience of delivered care were good for the majority of patients, while financial access and acceptability of care were considered as very limited. Bivariate analysis showed that acceptability and effectiveness of care were linked to CKD stage while the quality of patients’ information was correlated with their educational level. Furthermore, health coverage was also associated with financial accessibility of care but not with its availability. Conclusion: This study showed that access to care is poor for majority of patients with CKD in Saint-Louis. Identification of the main barriers will help define appropriate strategies to achieve universal access to quality renal care. 展开更多
关键词 Access to CARE CHRONIC KIDNEY Disease Saint-Louis
在线阅读 免费下载
Hydrocarbon’s Chronic Kidney Disease 认领
15
作者 Pierre Eric Gandzali-Ngabe Richard Loumingou +1 位作者 Hamadoun Yattara Donatien Moukassa 《肾脏病(英文)》 2020年第1期18-22,共5页
Hydrocarbons are dangerous for health, and American Society of Nephrology has already described renal involvement by Hydrocarbon. The Republic of Congo produces oil but there is no study among these working with hydro... Hydrocarbons are dangerous for health, and American Society of Nephrology has already described renal involvement by Hydrocarbon. The Republic of Congo produces oil but there is no study among these working with hydrocarbon to evaluate their renal status. The patient of 39 years working for 5 years as carrier oil, with high exposure to oil or more than 2 hours per day. He has no history of herbal medicine, no edema, no diabetes, no high blood pressure and he was not suffering from infectious diseases and there was no concept of kidney disease in the family. He was hospitalized for febrile generalized tonic convulsions with impaired renal function. After patient stabilization, clinical and biological examinations allowed us to conclude the chronic glomerulonephritis syndrome in five stages of chronic kidney disease. As creatinine at the entrance was 195 mg/l, clearance was 3 ml/min 1.72 m2 by CKD-EPI. The entrance to the BUN was 3.57 g/l. The albumin to creatinine ratio of urinary of 300 mg/g (ACR) is a glomerular disease. HIV serology test was negative. The abdominal-pelvic ultrasound revealed dedifferentiated kidneys of normal size. The patient received 7 hemodialysis sessions with femoral right catheter with heparin. The evolution was good and the patient was enrolled in chronic hemodialysis. This interference could be regarded as an occupational disease and we wish early detection. 展开更多
关键词 HYDROCARBON CHRONIC KIDNEY DISEASE The REPUBLIC of the CONGO
在线阅读 免费下载
Sickle Cell Patient and Addiction to Tramadol: Case Management in Senegal 认领
16
作者 Abou Sy Jean Augustin Diegane Tine +5 位作者 Safiyah Benmansour Samba Oumar Mamadou Ba Binta Diallo Aissatou Taiwo Lateef Sheikh Thiam Mamadou Habib 《健康(英文)》 2020年第2期99-105,共7页
Introduction: Tramadol* is a synthetic opioid agonist used as an analgesic. Despite its minor potential of addiction, it created recently a lot of concern. Its misuse may be motivated by a need to control the pain or ... Introduction: Tramadol* is a synthetic opioid agonist used as an analgesic. Despite its minor potential of addiction, it created recently a lot of concern. Its misuse may be motivated by a need to control the pain or by looking for her euphoric character. The aim of our study was to proceed a psychopathological reading of a case of addiction to Tramadol in a sickle cell patient with histrionic personality traits. Methods: We report the case’s management of a patient with addiction to Tramadol in a sickle cell patient with histrionic personality traits. The diagnosis was based on the DSM IV criteria. The review was done in the model of semi-structured interviews. Observation: Miss DP is 23 years old, sickle cell patient (AS profile). It is addressed to us for the management of an excessive consumption of Tramadol* started 4 years ago. Because of the difficulties of care in outpatient, we conducted hospitalization. The interviews highlight the histrionic personality traits and disruption of family dynamics. Discussion: Painful chronic diseases require a long analgesic treatment. It is a factor of dependence specially when the patient has a personality disorder. Multidisciplinary treatment between psychiatrist and addiction specialist and medical doctor is a guarantee of success. 展开更多
关键词 COMORBIDITY Derived OPIATE WITHDRAWAL Chronic PAIN Histrionic
在线阅读 免费下载
Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma 认领
17
作者 Jean Fidèle Nnang Essone Tatiana Harly Mba Aki Angue +5 位作者 Mounir Belmalih Rosalie Nkiéma Ludmila Betty Eke Ndouo Emmanuel Anyunzoghe Nathan Ekegue Félix Ovono Abessolo 《神经科学国际期刊(英文)》 2020年第1期42-67,共26页
Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin... Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG+. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG+ and 45 controls (CG-). The chi-2 test compared the proportions, and Spearman’s test studied the correlations between quantitative variables (p Results: CmNgb was 4.1 in CG+, versus 2.3 in CG- (p = 1.52 × 10-5). CmGpx was 1144.7 in CG+, versus 752.8 in GC- (p = 0.0199). CmHIF-1α was 4.1 in CG+, versus 3.5 in CG- (p = 0.4530). CmCyt C was 2303.26 in CG+, versus 1750.44 in CG- (p = 0.0450). In CG+, there was a correlation between CmNgb and CmGpx (r = 0.417;p = 0.004), CmNgb and CmHIF-1α (r = 0.644;p = 1.8 × 10-6), and between CmHIF-1α and CmGpx (r = 0.447;p = 0.002), CmHIF-1α and CmCyt C (r = 0.371;p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126;p = 0.370), as well as CmGpx and CmCyt C (r = 0.102;p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress biomarkers were found between CG+ and CG-, as well as their correlations, suggesting that neuroglobin overexpression is related to its anti-apoptotic, anti-oxidative, and anti-hypoxic properties. 展开更多
关键词 CHRONIC SEVERE GLAUCOMA NEUROGLOBIN Neuroprotective-Properties
在线阅读 免费下载
Effect of Social Media Used by Medical Professionals in Facilitating the Treatment of Chronic Illnesses 认领
18
作者 Hossam Alakhrass Waleed Alenazi Sameh Kamal Al-Akhrass 《健康(英文)》 2020年第2期127-131,共5页
The objective of this research is to describe the effect of social media use by medical professionals in facilitating the treatment of chronic illnesses in chronically ill individuals. This study focuses on the promin... The objective of this research is to describe the effect of social media use by medical professionals in facilitating the treatment of chronic illnesses in chronically ill individuals. This study focuses on the prominent social media used by medical professionals and the way it is used to manage health conditions of chronically ill individuals. 展开更多
关键词 DIABETES GLUCOSE Digital SOCIAL MEDIA Technology CHRONIC Illness
在线阅读 免费下载
Assessment of Urinary Albumin/Creatinine Ratio in Non-Obese Non-Diabetic Patients with Nonalcoholic Fatty Liver Disease 认领
19
作者 Ali Hussein Mohammed Ahmed Sedky +1 位作者 Hisham A. Alghany Algahlan Amr M. Zaghloul 《肠胃病学期刊(英文)》 2020年第4期61-71,共11页
Nonalcoholic fatty liver disease (NAFLD) is a pathological condition seen as histological change ranging from simple steatosis to steatohepatitis, advanced fibrosis and liver disease among patients without significant... Nonalcoholic fatty liver disease (NAFLD) is a pathological condition seen as histological change ranging from simple steatosis to steatohepatitis, advanced fibrosis and liver disease among patients without significant alcohol consumption. Microalbuminuria which is defined as the urinary albumin excretion of 30 - 300 mg/24h has been reported to be a risk factor for renal and cardiovascular disorders. It also has independent correlation to high mortality in diabetic and hypertensive patients. NAFLD is affecting non obese non diabetic individuals;Microalbuminuria is correlated to visceral adipose tissue even in non diabetic non obese patients with limited studies in this aspect. Microalbuminuria is considered as a risk factor for cardiovascular and chronic kidney disease. Aim of the work: To assess urinary albumin creatinine ratio in non-obese non-diabetic patients with nonalcoholic fatty liver disease. Patients and methods: Total number of 80 patients with NAFLD that were non diabetic non obese patients. Abdominal ultrasonography and laboratory investigations were done. Results: Eighty non-obese, non-diabetic subjects (32 women, 48 men) with the mean age of 50.9 were included in this study. The population of the study was classified into four groups according to ultrasonographic degrees of steatosis. Control Group (A), (No. 25) 31.25% of total cases are reported as no fat accumulation in liver. Group B;No. 21 26.25% of total cases are reported as had mild steatosis (NAFLD 1). Group C;No. 18 (22.5%) of total cases and reported as had moderate fat accumulation (moderate steatosis). Group D;No. 16 (20%) of total cases reported had severe fat accumulation (severe steatosis). Urinary albumin creatinine ratio also shows increase in its values with increasing in the degree of steatosis among different groups which is highly statistically significant. Triglycerides, total cholesterol and LDL show also significant changes between groups as they are significantly increased in value as regard increasing in degree of steatosis 展开更多
关键词 MICROALBUMINURIA NAFLD CHRONIC KIDNEY DISEASE
在线阅读 下载PDF
Etiologies of Chronic Renal Failure in Adolescent Patients at the University Hospital of Brazzaville 认领
20
作者 R. Loumingou J. Kambourou +1 位作者 B. Diall A. Mbika Cardorelle 《儿科学期刊(英文)》 2020年第1期168-174,共7页
Objectives:?The aim of our work was to identify the etiologies of chronic renal failure in adolescent patients.?Patients and Methods:?This is a descriptive cross-sectional retrospective study that included adolescents... Objectives:?The aim of our work was to identify the etiologies of chronic renal failure in adolescent patients.?Patients and Methods:?This is a descriptive cross-sectional retrospective study that included adolescents aged 10 to 19 years hospitalized between January 2014 and December 2017 in the department of nephrology at the?University Hospital of Brazzaville. The CRF was defined according to the ANAES criteria by an estimated glomerular filtration rate less than 60 ml/min/?1.73?m2?of body surface.?Results:?Forty cases of CRF were collected, representing a prevalence of 4.9%. The average age was 16.32 ± 3.64 years and the sex ratio was 3. The most common mode of discovery was edematous syndrome 62.5%. The most common etiology was glomerular nephropathies 60%, hereditary nephropathies 25% and malformative uropathies in 15%. Ten patients (25%) had moderate CFR at admission, 62.5% had severe CRF, 12.5% had terminal CFR?and all of them died during the year.?Conclusion:?Epidemiological data CRF in adolescent patients in developing countries are scarce and limit treatment. Glomerular pathologies represent the most frequent etiology. Early treatment of chronic renal failure in childhood and multidisciplinary collaboration between pediatrician and nephrologist are necessary. 展开更多
关键词 ADOLESCENT ETIOLOGIES Chronic RENAL Failure
在线阅读 免费下载
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈