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右半结肠毗邻层面的应用解剖学观察及其临床意义 预览
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作者 王旭 苏军龙 +4 位作者 马延生 王奔 刘力强 刘瑞廷 邱健 《中华结直肠疾病电子杂志》 2020年第1期68-75,共8页
目的应用尸体解剖方法研究右半结肠毗邻的层面关系,为精准右半结肠膜解剖手术提供可靠的应用解剖学依据。方法对经福尔马林固定的5具尸体(男性4具,女性1具)右半结肠毗邻层面进行解剖学观察。结果右半结肠与其周围的毗邻层面,形成了右To... 目的应用尸体解剖方法研究右半结肠毗邻的层面关系,为精准右半结肠膜解剖手术提供可靠的应用解剖学依据。方法对经福尔马林固定的5具尸体(男性4具,女性1具)右半结肠毗邻层面进行解剖学观察。结果右半结肠与其周围的毗邻层面,形成了右Toldt′s融合筋膜区、胰头十二指肠融合筋膜区、大网膜-横结肠融合筋膜区等三个区域。(1)右Toldt′s融合筋膜区:因回盲部、升结肠及其系膜筋膜背侧叶与原始后腹膜形成右Toldt′s融合筋膜而来。右Toldt′s融合筋膜区的头侧界为十二指肠环下缘,内侧界为肠系膜上动脉右缘,右侧与尾侧边界为回盲部、升结肠与后腹膜的愈着缘。在右Toldt′s融合筋膜区背侧依次存在后腹膜延续层面(原始后腹膜)和泌尿生殖层2个层面,依次形成了右Toldt′s融合筋膜间隙、肾前间隙和肾后间隙等三个间隙;(2)胰头十二指肠融合筋膜区:因结肠肝曲及其系膜筋膜背侧叶与胰头十二指肠固有筋膜形成融合筋膜而来。头侧界为胃大网膜在十二脂肠球部附着处,尾侧界为十二指肠环下缘,外侧界为十二指肠环外侧缘,内侧界为大网膜的右缘(其内标志为胃网膜右静脉)。胰头十二指肠融合筋膜区背侧依次为胰头十二指肠、后腹膜延续层面(原始后腹膜)和泌尿生殖层3个层面。依次形成了胰头十二指肠前间隙、胰头十二指肠后间隙、肾前间隙和肾后间隙等4个融合筋膜间隙。右Toldt′s融合筋膜间隙向头侧延续,被胰头十二指肠层面分隔为胰头十二指肠前间隙与胰头十二指肠后间隙;胰十二指肠前上静脉起自胰头,跨越胰头十二指肠前间隙,汇入肠系膜平面的Henle干(Henle trunk);(3)大网膜-横结肠融合筋膜区:起自大网膜右缘,向左侧由大网膜与横结肠系膜筋膜前叶融合而形成的区域。由腹侧向背侧形成网膜囊、胰周间隙和胰后间隙3个间隙。大网膜第3层覆盖� 展开更多
关键词 结肠 解剖 右半结肠 毗邻层面 应用解剖
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基于钕铁硼磁磁压榨技术在肠道吻合中的动物实验研究 预览
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作者 杨树建 吴荣谦 +9 位作者 郑学风 马锋 刘世松 乔玮 史爱华 胡继霖 高源 卢强 吕毅 卢云 《中华结直肠疾病电子杂志》 2020年第1期55-60,共6页
目的通过建立家兔结肠的磁压榨吻合模型,验证磁压榨吻合技术在结肠压榨吻合的可行性,并评估压榨吻合口的粪便转流功能。方法选取8只家兔,在结肠置入一定规格的磁铁实现肠道的侧侧压榨吻合,吻合口形成后,通过结肠造影、解剖观察及病理检... 目的通过建立家兔结肠的磁压榨吻合模型,验证磁压榨吻合技术在结肠压榨吻合的可行性,并评估压榨吻合口的粪便转流功能。方法选取8只家兔,在结肠置入一定规格的磁铁实现肠道的侧侧压榨吻合,吻合口形成后,通过结肠造影、解剖观察及病理检查的方法评估吻合口的形成情况。人为结扎吻合口之间的肠道制造肠梗阻动物模型,评估压榨吻合口的粪便转流功能。结果8只家兔均在术后第6~8天磁铁脱出;1只家兔发生肠梗阻,其余7只家兔吻合口形成良好。吻合口形成后,取3只家兔结扎吻合口之间肠道,1只家兔于术后第6天死亡,其余2只家兔长期存活,实现了压榨吻合口的粪便转流功能。结论磁压榨吻合技术能够实现家兔肠道的吻合,是一种有效的手术方式。 展开更多
关键词 结肠 胃肠吻合术 磁吻合术 磁压榨 消化道重建 动物模型
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胃空肠Roux-en-Y吻合术后吻合口-横结肠瘘一例 预览
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作者 刘书豪 张宪祥 卢云 《中华结直肠疾病电子杂志》 2020年第1期85-87,共3页
胃空肠Roux-en-Y吻合术后发生吻合口-横结肠瘘非常罕见,患者早期症状不明显且容易漏诊和误诊,典型三联征包括腹泻、体重减轻、粪性呕吐或粪性嗳气,确诊方式主要依据消化道造影和胃肠镜检查,对于明确诊断的患者需在营养状况改善的前提下... 胃空肠Roux-en-Y吻合术后发生吻合口-横结肠瘘非常罕见,患者早期症状不明显且容易漏诊和误诊,典型三联征包括腹泻、体重减轻、粪性呕吐或粪性嗳气,确诊方式主要依据消化道造影和胃肠镜检查,对于明确诊断的患者需在营养状况改善的前提下尽早行手术治疗。本例患者通过行上消化造影及胃镜检查确诊该疾病,经过积极的术前准备和一期手术治疗后,症状明显改善。现将本中心对该疾病的诊疗过程及治疗体会报道如下。 展开更多
关键词 结肠 胃肠吻合术 肠瘘 消化道重建
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乙状结肠造口皮肤黏膜深度分离影响因素的探究 预览
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作者 云红 张怡 +1 位作者 于洪霞 张梦怡 《中华结直肠疾病电子杂志》 2020年第1期92-95,共4页
目的探讨乙状结肠造口术后发生皮肤黏膜深度分离的影响因素。方法回顾性分析2016年3月至2019年5月间在中国医学科学院肿瘤医院结直肠外科收治的450例低位直肠癌行腹会阴联合切除术患者的临床资料,采用单因素分析及Logistic二分类多因素... 目的探讨乙状结肠造口术后发生皮肤黏膜深度分离的影响因素。方法回顾性分析2016年3月至2019年5月间在中国医学科学院肿瘤医院结直肠外科收治的450例低位直肠癌行腹会阴联合切除术患者的临床资料,采用单因素分析及Logistic二分类多因素回归分析法研究发生皮肤黏膜深度分离的临床独立影响因素。结果 450例研究对象中发生皮肤黏膜深度分离的患者36例,占8%。单因素分析结果显示,术前行新辅助治疗(P=0.028)、合并糖尿病(P=0.008)、低白蛋白(P=0.010)、术后肠黏膜坏死(P=0.030)、造口局部组织脂肪液化(P=0.038)是皮肤黏膜深度分离的影响因素。多因素回归分析结果显示:低白蛋白(OR=2.514,95%CI:1.217~5.134;P=0.01)、糖尿病(OR=3.014,95%CI:1.287~7.057;P=0.011)、肠黏膜坏死(OR=3.155,95%CI:1.036~9.610;P=0.043)、造口局部组织脂肪液化(OR=5.467,95%CI:1.754~17.038;P=0.003)是皮肤黏膜深度分离的独立影响因素。结论低白蛋白、糖尿病、术后肠造口黏膜坏死和造口局部组织脂肪液化为肠造口术后发生皮肤黏膜深度分离的独立影响因素。 展开更多
关键词 结肠 乙状 结肠造口术 皮肤黏膜深度分离 影响因素
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Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer 预览
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作者 Wan-Ru Ma Peng Xu +4 位作者 Zhao-Jun Liu Jing Zhou Lian-Kun Gu Jun Zhang Da-Jun Deng 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第2期184-198,共15页
BACKGROUND The expression of the membrane receptor protein GFRA1 is frequently upregulated in many cancers,which can promote cancer development by activating the classic RET-RAS-ERK and RET-RAS-PI3K-AKT pathways.Sever... BACKGROUND The expression of the membrane receptor protein GFRA1 is frequently upregulated in many cancers,which can promote cancer development by activating the classic RET-RAS-ERK and RET-RAS-PI3K-AKT pathways.Several therapeutic anti-GFRA1 antibody-drug conjugates are under development.Demethylation(or hypomethylation)of GFRA1 CpG islands(dmGFRA1)is associated with increased gene expression and metastasis risk of gastric cancer.However,it is unknown whether dmGFRA1 affects the metastasis of other cancers,including colon cancer(CC).AIM To study whether dmGFRA1 is a driver for CC metastasis and GFRA1 is a potential therapeutic target.METHODS CC and paired surgical margin tissue samples from 144 inpatients and normal colon mucosal biopsies from 21 noncancer patients were included in this study.The methylation status of GFRA1 islands was determined by MethyLight and denaturing high-performance liquid chromatography and bisulfite-sequencing.Kaplan-Meier analysis was used to explore the effect of dmGFRA1 on the survival of CC patients.Impacts of GFRA1 on CC cell proliferation and migration were evaluated by a battery of biological assays in vitro and in vivo.The phosphorylation of AKT and ERK proteins was examined by Western blot analysis.RESULTS The proportion of dmGFRA1 in CC,surgical margin,and normal colon tissues by MethyLight was 68.4%,73.4%,and 35.9%(median;nonparametric test,P=0.001 and<0.001),respectively.Using the median value of dmGFRA1 peak area proportion as the cutoff,the proportion of dmGFRA1-high samples was much higher in poorly differentiated CC samples than in moderately or welldifferentiated samples(92.3%%vs 55.8%,Chi-square test,P=0.002)and significantly higher in CC samples with distant metastasis than in samples without(77.8%vs 46.0%,P=0.021).The overall survival of patients with dmGFRA1-low CC was significantly longer than that of patients with dmGFRA1-high CC(adjusted hazard ratio=0.49,95%confidence interval:0.24-0.98),especially for 89 CC patients with metastatic CC(adjusted hazard ratio=0. 展开更多
关键词 GFRA1 DEMETHYLATION CpG island Colon cancer METASTASIS Membrane receptor
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Colonoscopic management of diverticular disease 预览
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作者 M Phillip Fejleh James H Tabibian 《世界胃肠内镜杂志:英文版(电子版)》 2020年第2期53-59,共7页
Diverticula are the most common incidental finding during routine colonoscopy,and their prevalence increases with patient age.The term“diverticular disease”encompasses the range of clinical manifestations and compli... Diverticula are the most common incidental finding during routine colonoscopy,and their prevalence increases with patient age.The term“diverticular disease”encompasses the range of clinical manifestations and complications that can occur with colonic diverticula,including diverticular bleeding,diverticulitisassociated strictures,and acute diverticulitis.Colonoscopy is a vital tool in the diagnosis and management of diverticular disease and can be useful in a variety of regards.In this editorial,we concisely delineate the current approach to and practices in colonoscopic management of diverticular disease.In particular,we discuss treatment options for diverticular bleeding,propose consideration of colonic stenting as a bridge to surgery in patients with diverticulitis-associated strictures,and the need for diagnostic colonoscopy following an episode of acute diverticulitis in order to rule out underlying conditions such as colonic malignancy or inflammatory bowel disease.In addition,we offer practical tips for performing safe and successful colonoscopy in patients with dense diverticulosis coli. 展开更多
关键词 Acute diverticulitis Diverticular bleeding Colon stricture
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Metabolite profile comparisons between ascending and descending colon tissue in healthy adults 预览
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作者 Bridget A Baxter Kristopher D Parker +4 位作者 Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第3期335-352,共18页
BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending a... BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished 展开更多
关键词 COLON Ascending DESCENDING Metabolomics OBESITY STOOL
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Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer:A retrospective observational study 预览
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作者 Man Wang Jia-Jie Lu +2 位作者 Wen-Jie Kong Xiao-Jing Kang Feng Gao 《世界临床病例杂志》 2019年第20期3217-3225,共9页
BACKGROUND Colorectal cancer is a common malignant tumor of the digestive tract.The relationship between sentinel polyps(rectal polyps with proximal colon cancer)and proximal colon cancer has received extensive attent... BACKGROUND Colorectal cancer is a common malignant tumor of the digestive tract.The relationship between sentinel polyps(rectal polyps with proximal colon cancer)and proximal colon cancer has received extensive attention in recent years.However,there is still no clear conclusion regarding the relationship.AIM To investigate the clinical characteristics of sentinel polyps and their correlation with proximal colon cancer.METHODS A retrospective analysis of 2587 patients with rectal polyps from January 2006 to December 2017 was performed.According to whether or not proximal colon cancer was diagnosed,the patients were divided into either a sentinel polyp group(192 patients)or a pure rectal polyp group(2395 patients).The endoscopic features,clinicopathological features,therapeutic effects,and short-term prognosis were analyzed and compared between the two groups.RESULTS The mean age of patients in the sentinel polyp group was generally higher than that of the pure rectal polyp group,and the positivity rates of anemia,stool occult blood,and tumor markers of the sentinel polyp group were also significantly higher than those in the rectal polyp group(χ^2=90.56,P<0.01;χ^2=70.30,P<0.01;χ^2=92.80,P<0.01).The majority of the patients in the sentinel polyp group had multiple polyps,large polyps,adenomatous polyps,or sessile polyps(χ^2=195.96,P<0.01;χ^2=460.46,P<0.01;χ^2=94.69,P<0.01;χ^2=48.01,P<0.01).Most of the proximal colon cancers were Duke’s A and B stages in the sentinel polyp group.In the pure rectal polyp group,2203 patients underwent endoscopic treatment,and all of the patients were cured and discharged.In the sentinel polyp group,65 patients underwent radical operation,and 61 patients received endoscopic submucosal dissection or endoscopic mucosal resection.Additionally,21 patients were lost to follow-up after 6-12 mo,and the loss rate was 10.94%.A total of 63.16%of patients experienced remission without tumor recurrence or metastasis,33.33%of patients experienced tumors regression or improved symptoms,and 展开更多
关键词 Sentinel polyps Rectal polyps Proximal colon cancer Ascending colon cancer Transverse colon cancer
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先天性袋状结肠的临床认识和诊治进展
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作者 虞贤贤 蔡威 施诚仁 《中华小儿外科杂志》 CSCD 北大核心 2019年第8期764-768,共5页
先天性袋状结肠是一种较为罕见的先天性畸形,表现为结肠缩短并呈明显的袋状扩张,同时多合并肛门直肠畸形,袋状扩张结肠一般通过瘘管与泌尿生殖道相连。先天性袋状结肠临床特征典型,诊断较为容易,但其临床处理及手术方式等存在争议,大多... 先天性袋状结肠是一种较为罕见的先天性畸形,表现为结肠缩短并呈明显的袋状扩张,同时多合并肛门直肠畸形,袋状扩张结肠一般通过瘘管与泌尿生殖道相连。先天性袋状结肠临床特征典型,诊断较为容易,但其临床处理及手术方式等存在争议,大多考虑先行造瘘进行分期手术,并根据剩余结肠的长度决定是否予以结肠成形。 展开更多
关键词 结肠 畸形 先天性袋状结肠
Closure of the Equine Nephrosplenic Space Using a Single LED Powered Trocar via Standing Mini-Laparotomy 预览
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作者 Christian Bussy Kossay Benredouane +1 位作者 Juan Munoz Diane Petat 《兽医学(英文)》 2019年第2期11-20,共10页
Objective: To evaluate a technique using a custom-developed LED powered Single Port Trocar for closure of the nephrosplenic space via a standing mini-laparotomy. Design: Prospective case series. Animals: 60 client-own... Objective: To evaluate a technique using a custom-developed LED powered Single Port Trocar for closure of the nephrosplenic space via a standing mini-laparotomy. Design: Prospective case series. Animals: 60 client-owned horses with a history of nephrosplenic entrapment. Procedures: The nephrosplenic space was closed under direct visualization through a specifically designed LED powered Single Port Trocar in standing sedated horses having experienced recurrence or previous surgical correction of a nephrosplenic entrapment. Obliteration of the space was performed in a cranial to caudal direction in a simple continuous fashion. Time required for suturing the nephrosplenic space, as well as per and post-operative complications were recorded. Clients and referring veterinarians were asked to communicate any complication that occurred after discharge. Results: Surgical time ranged from 23 to 45 min. No complication except for self-limited spleen capsule bleeding occurred during the procedure. Minor wound discharge was noted in 2 cases, and another 2 horses developed post-surgical sweating patches close to the incision. All horses were allowed to progressively resume exercise, starting 1 month post discharge from the hospital. Cosmetic results were considered satisfactory and no recurrence of left dorsal displacement of the colon was reported post-surgery. Conclusions and clinical relevance: A Single Port LED powered Trocar is a technique that allows effective, fast, and safe closure of the nephrosplenic space in the standing horse with minimal instrumentation. 展开更多
关键词 COLIC Colon Nephrosplenic ENTRAPMENT LAPAROTOMY
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Effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer
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作者 Gang Dai Hai-Qun Chen +2 位作者 Qing-Hao Gong Jie Zhang Ming Gao 《海南医科大学学报(英文版)》 2019年第4期46-49,共4页
Objective:To investigate the effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer. Method:140 patients with colon can... Objective:To investigate the effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer. Method:140 patients with colon cancer admitted to a hospital from January 2016 to November 2017 were divided into control group and observation group according to the operation method, 70 cases in each group. The control group was treated with open radical resection of colon cancer, while the observation group was treated with laparoscopic radical resection of colon cancer. The changes of immune function, stress response, visceral protein and gastrointestinal hormone were compared between the two groups before and after treatment.Results:There was no significant difference in immune function, stress response, visceral protein and gastrointestinal hormone between the two groups before operation (P>0.05). The ratio of Th1 cells was decreased, while the ratio of Th2, Th17 and Treg cells was increased in the two groups (P<0.05). The proportion of Th1 cells in the observation group was higher than that in the control group,while the ratio of Th2, Th17 and Treg cells in the observation group was lower than that of the control group (P<0.05). The levels of Cor, E and NE were increased in the two groups (P<0.05). And the levels of Cor, E and NE in the observation group were lower than those in the control group (P<0.05). The levels of PA, TRF and RBP were decreased in the two groups (P<0.05). And PA, TRF and RBP levels were higher in the observation group than in the control group (P<0.05). The GAS, MTL and GIP levels were lower in the two groups (P<0.05). And the GAS, MTL and GIP levels in the observation group were higher than those in the control group (P<0.05).Conclusion: Laparoscopic radical mastectomy has little effect on the immune function of patients. It can alleviate the surgical stress response to a certain extent, which is beneficial to the recovery of gastrointestinal function and can be extended to clinical application. 展开更多
关键词 LAPAROSCOPIC COLON CANCER radical surgery COLON CANCER Immune FUNCTION Gastrointestinal FUNCTION
棕果蝠胃及肠道的解剖与组织结构的初步观察 预览
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作者 刘为民 林俊青 +5 位作者 罗来福 叶亚琼 赵海全 张晖 陈芳 吕宗吉 《佛山科学技术学院学报:自然科学版》 CAS 2019年第5期1-6,共6页
采用大体及组织学方法观察了产自广东省云浮市野生棕果蝠(Rousettus leschenaulti)的胃和肠道。棕果蝠的胃具有食果蝙蝠的特征,即具有管状的胃底盲囊以及发达的贲门前庭和幽门部。本研究将棕果蝠的胃划分为4个部分:即贲门部、胃底部、... 采用大体及组织学方法观察了产自广东省云浮市野生棕果蝠(Rousettus leschenaulti)的胃和肠道。棕果蝠的胃具有食果蝙蝠的特征,即具有管状的胃底盲囊以及发达的贲门前庭和幽门部。本研究将棕果蝠的胃划分为4个部分:即贲门部、胃底部、胃体部和幽门部,幽门部又进一步分为降段和升段。在贲门部、胃底部、胃体部和幽门部的降段黏膜全部为胃底腺被覆,而在幽门部的升段分布有幽门腺。在幽门括约肌周边没有十二指肠腺分布。棕果蝠肠管分为小肠和大肠两部分。小肠可分为十二指肠和空-回肠。十二指肠较发达,总长约10 cm,可分为前水平部、前曲、降部、后曲和升部。肠绒毛为纵向平行的嵴状或板状,个别例为叶片状。未见十二指肠腺。空-回肠较长,约36~48 cm,其黏膜形成纵向嵴状或板状。大肠较发达,总长约14 cm,包括前结肠、升结肠、横结肠、降结肠和直肠,不含盲肠和阑尾。 展开更多
关键词 棕果蝠 十二指肠 结肠 肠绒毛
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Race,the microbiome and colorectal cancer 预览
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作者 Kendra J Royston Babatunde Adedokun Olufunmilayo I Olopade 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第10期773-787,共15页
In the past decade,more cancer researchers have begun to understand the significance of cancer prevention,which has prompted a shift in the increasing body of scientific literature.An area of fascination and great pot... In the past decade,more cancer researchers have begun to understand the significance of cancer prevention,which has prompted a shift in the increasing body of scientific literature.An area of fascination and great potential is the human microbiome.Recent studies suggest that the gut microbiota has significant roles in an individual’s ability to avoid cancer,with considerable focus on the gut microbiome and colorectal cancer.That in mind,racial disparities with regard to colorectal cancer treatment and prevention are generally understudied despite higher incidence and mortality rates among Non-Hispanic Blacks compared to other racial and ethnic groups in the United States.A comprehension of ethnic differences with relation to colorectal cancer,dietary habits and the microbiome is a meritorious area of investigation.This review highlights literature that identifies and bridges the gap in understanding the role of the human microbiome in racial disparities across colorectal cancer.Herein,we explore the differences in the gut microbiota,common short chain fatty acids produced in abundance by microbes,and their association with racial differences in cancer acquisition. 展开更多
关键词 DIET EPIGENETICS MICROBIOME DISPARITIES Colorectal COLON Cancer
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Hydatid cyst of the colon: A systematic review of the literature 预览
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作者 Miguel Angel Latatu-Córdoba Sergio Ruiz-Blanco +4 位作者 Matilde Sanchez Carmen Santiago-Boyero Paula Soto-García Wenzhong Sun José M Ramia 《世界临床病例杂志》 2019年第13期1634-1642,共9页
BACKGROUND Primary hydatid disease in the colon is an extremely rare finding. We performed a systematic review of cases of hydatidosis of the colon published to date. AIM To systematic review the published papers abou... BACKGROUND Primary hydatid disease in the colon is an extremely rare finding. We performed a systematic review of cases of hydatidosis of the colon published to date. AIM To systematic review the published papers about hydatidosis of the colon. METHODS Following PRISMA guidelines, we performed an unlimited search for articles on CH in the MEDLINE (PubMed), EMBASE, Cochrane, Latindex and Scielo databases, published in English, Spanish, French, German or Italian between January 1, 1960 and December 15, 2018. The search items were:(Colon) AND [(hydatidosis) OR (hydatid disease) OR (echinococcosis)]. RESULTS Nine case reports were found [five men, four women, median age 64.55 years (range: 21-81)]. The most frequent clinical manifestation was abdominal pain (8/9)(88.9%). In almost all cases several image studies were carried out, but abdominal computed tomography was the most used (66.7%). Five resections of the colon (62.5%) and three sutures of the fistula between cyst and colon (37.5%) were performed. Four patients did not present post-operative complications, but one died. Postoperative period was recorded for a mean period of 35 months. No recurrences were recorded. CONCLUSION The most frequent symptom was abdominal pain (evidence level 4). Computed tomography was the most frequently used diagnostic imaging technique (evidence level 4). Colectomy was the most appropriate treatment (evidence level 5). All the diagnostic and therapeutic options for hydatid cysts located in colon have a low level of evidence. 展开更多
关键词 ECHINOCOCCOSIS HYDATIDOSIS HYDATID CYST COLON SURGERY Review
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内镜下球囊扩张术治疗结直肠吻合口良性狭窄的临床回顾性分析
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作者 李冰 周平红 +7 位作者 姚礼庆 徐美东 任重 时强 陈涛 蔡世伦 齐志鹏 钟芸诗 《中华消化内镜杂志》 CSCD 北大核心 2019年第7期479-482,共4页
目的评价内镜下球囊扩张术(EBD)治疗结直肠吻合口良性狭窄的安全性及疗效。方法2011年至2015年,复旦大学附属中山医院内镜中心行EBD治疗的36例结直肠吻合口良性狭窄病例纳入回顾性分析,统计扩张治疗次数、并发症发生情况、短期效果及长... 目的评价内镜下球囊扩张术(EBD)治疗结直肠吻合口良性狭窄的安全性及疗效。方法2011年至2015年,复旦大学附属中山医院内镜中心行EBD治疗的36例结直肠吻合口良性狭窄病例纳入回顾性分析,统计扩张治疗次数、并发症发生情况、短期效果及长期狭窄复发情况。结果36例患者在外科手术后2~49个月(中位时间6个月)出现吻合口狭窄,吻合口距肛缘3~24cm(中位距离6cm)o10例(27.8%)为1级狭窄,15例(41.7%)为2级狭窄,11例(30.5%)为3级狭窄。36例共行80次EBD,平均每例2.22次,其中行1.2次25例(69.4%)、3次及以上11例(30.6%).EBD操作过程中,14例次(17.5%)出现吻合口少量渗血,无术中及术后穿孔发生。术后所有患者梗阻症状得到解除,吻合口直径大于20mm,EBD治疗取得成功。术后随访22~76个月(中位时间44个月),其中4例(11.1%)在EBD治疗成功后再次出现吻合口良性狭窄,出现时间分别为末次扩张术后的7、11、18、63个月,均经再次EBD治疗后好转。结论EBD在治疗结直肠吻合口良性狭窄方面安全有效,能取得较为理想的短期和长期结局。 展开更多
关键词 结肠 直肠 外科吻合口 良性狭窄 内镜下球囊扩张术
Colon cancer arising from colonic diverticulum: A case report 预览
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作者 Hajime Kayano Yusuhiko Ueda +5 位作者 Takashi Machida Shinichiro Hiraiwa Hidenori Zakoji Takuma Tajiri Masaya Mukai Eiji Nomura 《世界临床病例杂志》 2019年第13期1643-1651,共9页
BACKGROUND Colonic diverticulosis is a common disease, and the coexistence of colonic diverticulosis and colorectal cancer is often seen clinically. It is very rare that colon cancer arises from the mucosa of a coloni... BACKGROUND Colonic diverticulosis is a common disease, and the coexistence of colonic diverticulosis and colorectal cancer is often seen clinically. It is very rare that colon cancer arises from the mucosa of a colonic diverticulum. When colon cancer arises in a diverticulum and then tends to develop outside the wall, without developing within the lumen, the differential diagnosis from complicating lesions due to colonic diverticulitis is difficult. CASE SUMMARY A 76-year-old man was admitted to a nearby clinic with a chief complaint of discomfort and urinary frequency. Since a vesicosigmoidal fistula was seen on abdominal computed tomography, he was referred to our hospital. Laparoscopic sigmoidectomy was performed because the various diagnostic findings were diagnosed as a vesicosigmoidal fistula with diverticulitis of the sigmoid colon. However, on histopathological examination, it was diagnosed as a vesicosigmoidal fistula due to colon cancer arising in the diverticulum. Laparoscopic partial resection of the bladder was performed because local recurrence was observed in the bladder wall one and a half years after surgery. It is currently one year after reoperation, but there has been no recurrence or metastasis. CONCLUSION Colon cancer arising in a diverticulum of the colon should be considered when diverticulitis with complications is observed. 展开更多
关键词 COLON cancer DIVERTICULUM Colovesical FISTULA Laparoscopic surgery DIVERTICULITIS Case report
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Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis 预览
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作者 Yu Liang Cheng Zhang Dong-Qiu Dai 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第26期3392-3407,共16页
BACKGROUND DNA methylation, acknowledged as a key modification in the field of epigenetics, regulates gene expression at the transcriptional level. Aberrant methylation in DNA regulatory regions could upregulate oncog... BACKGROUND DNA methylation, acknowledged as a key modification in the field of epigenetics, regulates gene expression at the transcriptional level. Aberrant methylation in DNA regulatory regions could upregulate oncogenes and downregulate tumor suppressor genes without changing the sequences.However, studies of methylation in the control of gene expression are still inadequate. In the present research, we performed bioinformatics analysis to clarify the function of methylation and supply candidate methylation-related biomarkers and drivers for colon cancer.AIM To identify and analyze methylation-regulated differentially expressed genes(MeDEGs) in colon cancer by bioinformatics analysis.METHODS We downloaded RNA expression profiles, Illumina Human Methylation 450 K BeadChip data, and clinical data of colon cancer from The Cancer Genome Atlas project. MeDEGs were identified by analyzing the gene expression and methylation levels using the edgeR and limma package in R software. Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses were performed in the DAVID database and KEGG Orthology-Based Annotation System 3.0, respectively. We then conducted Kaplan–Meier survival analysis to explore the relationship between methylation and expression and prognosis. Gene set enrichment analysis(GSEA) and investigation of protein-protein interactions(PPI) were performed to clarify the function of prognosis-related genes.RESULTS A total of 5 up-regulated and 81 down-regulated genes were identified asMeDEGs. GO and KEGG pathway analyses indicated that MeDEGs were enriched in multiple cancer-related terms. Furthermore, Kaplan–Meier survival analysis showed that the prognosis was negatively associated with the methylation status of glial cell-derived neurotrophic factor(GDNF) and reelin(RELN). In PPI networks, GDNF and RELN interact with neural cell adhesion molecule 1. Besides, GDNF can interact with GDNF family receptor alpha(GFRA1), GFRA2, GFRA3, and RET. RELN can interact with RAFAH1 B 展开更多
关键词 COLON CANCER BIOINFORMATICS analysis The CANCER Genome Atlas project DNA METHYLATION Methylation-regulated DIFFERENTIALLY expressed genes Overall survival
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Patients with Crohn’s disease have longer post-operative in-hospital stay than patients with colon cancer but no difference in complications’rate 预览
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作者 2015 European Society of Coloproctology(ESCP)collaborating group Alaa El-Hussuna 《世界胃肠外科杂志:英文版(电子版)》 2019年第5期261-270,共10页
BACKGROUND Right hemicolectomy or ileocecal resection are used to treat benign conditions like Crohn’s disease(CD)and malignant ones like colon cancer(CC).AIM To investigate differences in pre-and peri-operative fact... BACKGROUND Right hemicolectomy or ileocecal resection are used to treat benign conditions like Crohn’s disease(CD)and malignant ones like colon cancer(CC).AIM To investigate differences in pre-and peri-operative factors and their impact on post-operative outcome in patients with CC and CD.METHODS This is a sub-group analysis of the European Society of Coloproctology’s prospective,multi-centre snapshot audit.Adult patients with CC and CD undergoing right hemicolectomy or ileocecal resection were included.Primary outcome measure was 30-d post-operative complications.Secondary outcome measures were post-operative length of stay(LOS)at and readmission.RESULTS Three hundred and seventy-five patients with CD and 2,515 patients with CC were included.Patients with CD were younger(median=37 years for CD and 71 years for CC(P<0.01),had lower American Society of Anesthesiology score(ASA)grade(P<0.01)and less comorbidity(P<0.01),but were more likely to be current smokers(P<0.01).Patients with CD were more frequently operated on by colorectal surgeons(P<0.01)and frequently underwent ileocecal resection(P<0.01)with higher rate of de-functioning/primary stoma construction(P<0.01).Thirty-day post-operative mortality occurred exclusively in the CC group(66/2515,2.3%).In multivariate analyses,the risk of post-operative complications was similar in the two groups(OR 0.80,95%CI:0.54-1.17;P=0.25).Patients with CD had a significantly longer LOS(Geometric mean 0.87,95%CI:0.79-0.95;P<0.01).There was no difference in re-admission rates.The audit did not collect data on post-operative enhanced recovery protocols that are implemented in the different participating centers.CONCLUSION Patients with CD were younger,with lower ASA grade,less comorbidity,operated on by experienced surgeons and underwent less radical resection but had a longer LOS than patients with CC although complications'rate was not different between the two groups. 展开更多
关键词 Crohn’s disease COLON cancer Complications Length of stay Bowel resection Right HEMICOLECTOMY
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苜蓿草粉和黄酮对断奶仔猪结肠微生物区系的影响 预览
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作者 曲根 刘建宇 +6 位作者 郭志鹏 王苗利 管永卓 张靖雪 郭玉霞 严学兵 张明 《草业学报》 CSCD 北大核心 2019年第6期175-184,共10页
本试验旨在研究苜蓿草粉和苜蓿黄酮对断奶仔猪结肠微生物区系的影响。选取平均体重为(8.1±0.5) kg和胎次相近的(35±1)日龄"杜×长×大"三元杂交断奶仔猪120头,随机分成5组(每组3个重复,每个重复8头猪):对... 本试验旨在研究苜蓿草粉和苜蓿黄酮对断奶仔猪结肠微生物区系的影响。选取平均体重为(8.1±0.5) kg和胎次相近的(35±1)日龄"杜×长×大"三元杂交断奶仔猪120头,随机分成5组(每组3个重复,每个重复8头猪):对照组饲喂基础饲粮,试验组分别添加1(Ⅰ组)、2(Ⅱ组)、4(Ⅲ组)g·kg~(-1)的苜蓿黄酮和50 g·kg~(-1)的苜蓿草粉(Ⅳ组);预试验期3 d,正式试验期32 d。试验采集的结肠内容物,提取总DNA后在Illumina Miseq平台进行测序。结果表明:1)5个组共产生了484个操作分类单元(operational taxonomic units,OTUs),其中共享327个OTU,占总OTU数量的67.56%,其中Ⅰ组的OTU数量最高。2)物种丰富度ACE指数(community richness the ACE estimator,ACE)呈先上升再下降再上升趋势,其中Ⅰ组显著高于对照组(P<0.05);物种丰富度Chao指数(community richness the Chao estimator,Chao)呈先上升再下降再上升趋势,其中Ⅰ组显著高于对照组(P<0.05)。与对照组相比,Ⅳ组的Sobs(the observed richness,Sobs)、ACE、Chao指数均无显著差异(P>0.05)。各组之间的Shannon指数和Simpson指数均无显著差异(P>0.05)。3)在门水平上,各组间厚壁菌门和拟杆菌门的相对丰度均无显著差异(P>0.05)。在属水平上,各组间梭菌属相对丰度有升高的趋势(P>0.05),其中Ⅰ组和Ⅲ组梭菌属相对丰度显著高于对照组(P<0.05)。与对照组相比,Ⅱ组粪球菌属相对丰度显著提高(P<0.05)。各组间真细菌属相对丰度有升高的趋势(P>0.05),其中Ⅱ组真细菌属相对丰度显著高于对照组(P<0.05)。各组间Anaerotruncus相对丰度有显著差异(P<0.05),其中Ⅱ组和Ⅳ组显著高于对照组(P<0.05);各组间NC2004相对丰度有差异(P>0.05),其中Ⅲ组NC2004相对丰度显著提高(P<0.05)。各组间UCG-014、Erysipelotrichaceae和胃球菌属相对丰度有显著差异(P<0.05)。由此可见,饲粮中添加苜蓿草粉和苜蓿黄酮能够改变结肠微生物细菌组成和结构,进而影响营养� 展开更多
关键词 苜蓿 苜蓿黄酮 断奶仔猪 结肠 微生物区系
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升结肠癌合并早期胃癌同时性双原发癌1例报道 预览
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作者 曾小辉 杨兵 叶进军 《胃肠病学和肝病学杂志》 CAS 2019年第9期1079-1080,共2页
多原发癌(multiple primary carcinomas,MPC)发病率低,近期我们诊断1例升结肠癌合并早期胃癌同时性双原发癌,并成功施行根治性外科手术治疗,术后无复发,避免了误诊和漏诊,结合国内外相关文献进行复习,以此提高临床医师对MPC的认识。
关键词 结肠 肿瘤 多原发癌 诊断 治疗 预后
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