期刊文献+
共找到1,623篇文章
< 1 2 82 >
每页显示 20 50 100
Perioperative rh-endostatin with chemotherapy improves the survival of conventional osteosarcoma patients: a prospective non-randomized controlled study 预览
1
作者 Hairong Xu Zhen Huang +3 位作者 Yuan Li Qing Zhang Lin Hao Xiaohui Niu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期166-172,共7页
Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the ... Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the probability of distant metastasis-free survival(DMFS) and overall survival(OS) in patients newly diagnosed with non-metastatic conventional osteosarcoma.Methods: This was a controlled non-randomized clinical study that included 388 patients without clinically detectable metastatic disease enrolled from January 2008 to April 2012. The control treatment group had 272 patients;180 were male and 92, female,with a median age of 17 years. The treatment group had 58 patients;36 were male and 22, female, with a median age of 16 years.The control group received preoperative chemotherapy followed by surgery and postoperative chemotherapy. The treatment group received 4 cycles of rh-endostatin perioperatively in addition to chemotherapy as per the control group. Patients were followed up from 6-101 months with a median follow-up period of 50.2 months.Results: The 5-year DMFS of the control group(61%) was significantly lower than that of the rh-endostatin group(79%)(P = 0.013). The 5-year OS of the control group(74%) was significantly lower than that of the rh-endostatin treatment group(87%)(P = 0.029). No difference in adverse drug reactions was found between these 2 groups.Conclusions: The addition of perioperative rh-endostatin to chemotherapy could significantly improve the DMFS and OS of patients with non-metastatic osteosarcoma. 展开更多
关键词 OSTEOSARCOMA rh-endostatin PERIOPERATIVE DISTANT metastasis overall SURVIVAL
在线阅读 下载PDF
Stereotactic body radiation therapy for non-small cell lung cancer:A review 预览
2
作者 Kavitha M Prezzano Sung Jun Ma +3 位作者 Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh 《世界临床肿瘤学杂志(英文版)》 2019年第1期14-27,共14页
Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databas... Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databases was completed in July 2018.Inclusion and exclusion criteria were determined prior to the search,and only prospective clinical trials were included.Nineteen trials from 2005 to 2018 met the inclusion criteria,reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC.Patient eligibility,prescription dose and delivery,and follow up duration varied widely.Threeyears overall survival ranged from 43%to 95%with loco-regional control of up to 98%at 3 years.Up to 33%of patients failed distantly after SBRT at 3 years.SBRT was generally well tolerated with 10%-30%grade 3-4 toxicities and a few treatment-related deaths.No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT,central and peripheral lung tumors,or inoperable and operable patients.SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC.SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery.Decreasing fractionation schedules have been consistently shown to be both safe and effective.Distant failure is common,and chemotherapy may be considered for select patients.However,the survival benefit of additional interventions,such as chemotherapy,for early stage NSCLC treated with SBRT remains unclear. 展开更多
关键词 LUNG CANCER NON-SMALL cell LUNG CANCER STEREOTACTIC body radiation therapy STEREOTACTIC ABLATIVE radiotherapy DISTANT failure
在线阅读 免费下载
Establishment and application of distant hybridization technology in fish
3
作者 Shi Wang Chenchen Tang +11 位作者 Min Tao Qinbo Qin Chun Zhang Kaikun Luo Rurong Zhao Jing Wang Li Ren Jun Xiao Fangznou Hu Rong Zhou Wei Duan Shaojun Liu 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第1期22-45,共24页
Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated an... Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated and obtained the main rules regarding inheritance and reproduction related to fish distant hybridization. Furthermore, we established one-step and multistep breeding technologies that were suitable for interspecific hybridization and intraspecific hybridization. Simultaneously, we used these two breeding technologies to produce a batch of diploid fish lineages and tetraploid fish lineages and improved fishes. In addition, we widely discuss the methods, technologies and results of hybridization breeding, referring to the domestic and foreign literature on fish hybridization. We hope that this paper will be beneficial for the research and application of fish hybrid breeding. 展开更多
关键词 FISH DISTANT HYBRIDIZATION INTRASPECIFIC HYBRIDIZATION breeding TECHNOLOGY LINEAGE
Impact of duration of adjuvant chemotherapy in radically resected patients with T4bN1-3M0/TxN3bM0 gastric cancer 预览
4
作者 Qi-Wei Wang Xiao-Tian Zhang +1 位作者 Ming Lu Lin Shen 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2018年第1期31-39,共9页
AIM To provide evidence regarding the postoperative treatment of patients with T4bN1-3M0/TxN3bM0 gastric cancer,for which guidelines have not been established.METHODS Patients who had undergone curative resection betw... AIM To provide evidence regarding the postoperative treatment of patients with T4bN1-3M0/TxN3bM0 gastric cancer,for which guidelines have not been established.METHODS Patients who had undergone curative resection between 1996 and 2014 with a pathological stage of T4bN1-3M0/TxN3bM0 for gastric cancer were retrospectively analyzed;staging was based on the 7th edition of the American Joint Committee on Cancer staging system.The clinicopathological characteristics,administration of adjuvant chemotherapy,and patterns of recurrence were studied.Univariate and multivariate analyses of prognostic factors were conducted.The chemotherapeutic agents mainly included fluorouropyrimidine,platinum and taxanes,used as monotherapy,doublet,or triplet regimens.Patterns of first recurrence were categorized as locoregional recurrence,peritoneal dissemination,or distant metastasis.RESULTS The 5-year overall survival(OS)of the whole group(n=176)was 16.8%,and the median OS was 25.7 mo(95%CI:20.9-30.5).Lymphovascular invasion and a node positive rate(NPR)≥0.8 were associated with a poor prognosis(P=0.01 and P=0.048,respectively).One hundred forty-seven(83.5%)of the 176 patients eventually experienced recurrence;the most common pattern of the first recurrence was distant metastasis.The prognosis was best for patients with locoregional recurrence and worst for those with peritoneal dissemination.Twelve(6.8%)of the 176 patients did not receive adjuvant chemotherapy,while 164(93.2%)patients received adjuvant chemotherapy.Combined chemotherapy,including doublet and triplet regimens,was associated with a better prognosis than monotherapy,with no significant difference in 5-year OS(17.5%vs 0%,P=0.613).The triplet regimen showed no significant survival benefit compared with the doublet regimen for 5-year OS(18.5%vs 17.4%,P=0.661).Thirty-nine(22.1%)patients received adjuvant chemotherapy for longer than six months;the median OS in patients who received adjuvant chemotherapy for longer than six months was 40.2 mo(95%CI:30.6-48.2),significantly l 展开更多
关键词 Gastric cancer T4bN1-3M0/TxN3bM0 RECURRENCE DISTANT metastasis ADJUVANT CHEMOTHERAPY
在线阅读 免费下载
Analysis of a Rainstorm Process Far from the Typhoon "Haitang" 预览
5
作者 Liu Ruixiang Gu Chunlei +2 位作者 Ding Shasha Zhang Yinyi Wang Guichen 《气象与环境研究:英文版》 CAS 2017年第5期30-36,共7页
Based on multiple kinds of observation data and NCEP/NCAR reanalysis data, the circulation background, cloud clusters and radar characteristics of a rainstorm far from the typhoon " Haitang" in Lianyungang, ... Based on multiple kinds of observation data and NCEP/NCAR reanalysis data, the circulation background, cloud clusters and radar characteristics of a rainstorm far from the typhoon " Haitang" in Lianyungang, Jiangsu on the morning of July 31,2017 were analyzed, and causes of convection were discussed from the aspects of dynamic, thermal and water vapor conditions. The results showed that the rainstorm process was caused by convection cells with low center of mass, and strong convection mainly occurred in a position where temperature gradient at cloud top was the largest. In North China at 850 hPa, eastern cold air on the south side of anticyclonic circulation moved southwards and joined southeast air flow on the periphery of typhoon, which was the main reason for the occurrence of convection. The circulation of upper-level divergence and lowerlevel convergence was beneficial to the maintaining of convection. The convergence of southeast wind speed on the periphery of typhoon made water vapor accumulate, thereby providing enough water vapor for the appearance of heavy rainfall. Kindex had good denotative meaning to convection activity, and the process of convection with weak Cape value needs to be paid special attention to in business. The prediction effect of rainfall distribution and areas by the models EC and ECRC was superior to other models. 展开更多
关键词 TYPHOON DISTANT RAINSTORM Low MASS of center Water vapor CONVERGENCE Prediction
在线阅读 下载PDF
Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein–Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma 预览 被引量:1
6
《癌症:英文版》 SCIE CAS CSCD 2017年第12期737-743,共7页
Background: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patient... Background: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein–Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients.Methods: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed.Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic (ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan–Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression model.Results: The 5-year distant metastasis-free survival (DMFS) rates for patients with GTVnd > 18.9 vs. ≤ 18.9 mL were 82.2% vs. 93.2% (P < 0.001), and for patients with EBV DNA copy number > 4000 vs. ≤ 4000 copies/mL were 83.5% vs.93.9% (P < 0.001). After adjusting for GTVnd, EBV DNA copy number, and T category in the Cox regression model, both GTVnd > 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients were divided into low-,moderate 展开更多
关键词 Nasopharyngeal carcinoma LYMPH node VOLUME Epstein–Barr VIRUS DNA DISTANT metastasis Prognostic model
在线阅读 下载PDF
First live birth evidence in dinosaur relative
7
作者 周越 《数理天地:高中版》 2017年第3期48-49,共2页
Scientists have uncovered the first evidence of live births in the group of animals that includes dinosaurs,crocodiles and birds.6500万年前就灭绝的恐龙也好,活化石鳄鱼也好,鸟也好,
关键词 BIRDS fossil BIRTH PRESERVED Montana probably bones reproduction EMBRYO DISTANT
North Azadegan, A Distant Place 预览
8
《中国油气:英文版》 CAS 2017年第2期61-62,133-134共4页
The sandstorm has lasted for three days, coloring the sky with the tintof pale yellow. Looking up, one can see fine sand covering the roof of thecamper. When I meet Zhou Bing, who is dressed in an orange outfit and we... The sandstorm has lasted for three days, coloring the sky with the tintof pale yellow. Looking up, one can see fine sand covering the roof of thecamper. When I meet Zhou Bing, who is dressed in an orange outfit and wearsa white safety helmet, a pair of black safety sunglasses and a checkeredkeffiyeh, he is just coming back from the Center Processing Facilities(CPF) after an HSSE inspection. If judged from his attire, he looks nodifferent from the local Iranian employees. 展开更多
关键词 NORTH Azadegan A DISTANT PLACE
在线阅读 下载PDF
My Father’s Eyes——天地父子情 预览
9
作者 张仪 《新东方英语:中英文版》 2016年第7期24-25,共2页
父亲之爱相较于母亲的细致与唠叨,往往显得隐忍、含蓄。所以,我们常说严父慈母、父爱如山。对于儿女而言,很多人常常是长大成年甚至为人父母后才真正理解父爱的厚重与不易。但无论如何,有父爱就是幸福的,那是一种如钢似铁的精神支柱与... 父亲之爱相较于母亲的细致与唠叨,往往显得隐忍、含蓄。所以,我们常说严父慈母、父爱如山。对于儿女而言,很多人常常是长大成年甚至为人父母后才真正理解父爱的厚重与不易。但无论如何,有父爱就是幸福的,那是一种如钢似铁的精神支柱与寄托。然而,不是所有人都能幸运地享受到父爱。譬如英国摇滚布鲁斯歌手Eric Clapton,他一生未与父亲谋面,中年又尝丧子之痛,这种无父爱眷顾、亲情又无处安放的痛苦全都寄托在歌曲《父亲的眼睛》(My Father’s Eyes)里。 展开更多
关键词 父子情 MY FATHER s EYES 布鲁斯 FATHER tears distant RESTORE SEEDLING teach
在线阅读 下载PDF
The quest for an accurate measurement of cosmic shear
10
作者 Jun Zhang 《国家科学评论:英文版》 CSCD 2016年第2期159-160,共2页
<正>Gravitational lensing refers to the deflection of light of distant sources by the intervening gravity field.This effect is well described in the theory of general relativity and can be observed by measuring ... <正>Gravitational lensing refers to the deflection of light of distant sources by the intervening gravity field.This effect is well described in the theory of general relativity and can be observed by measuring the systematic shape distortions of background galaxy images.Since the 展开更多
关键词 galaxy DISTANT COSMIC gravity deflection morphol challenging GALAXIES REALISTIC PIXEL
自然讲解中心 预览
11
《世界建筑导报》 2015年第3期92-93,共2页
业主:Salinas de Janubio SL地点:西班牙兰萨罗特设计:2010年合作:Alejandro Cervilla García,Miguel Ciria Hernández黑色平面在远方的地平线和西面的大海衬托下,火山岛的"picon"(火山灰或火山石)构成了一种罕见的... 业主:Salinas de Janubio SL地点:西班牙兰萨罗特设计:2010年合作:Alejandro Cervilla García,Miguel Ciria Hernández黑色平面在远方的地平线和西面的大海衬托下,火山岛的"picon"(火山灰或火山石)构成了一种罕见的黑色地貌。丘陵形成了一个自然环带,围绕着一个延伸到大海的平坦区域,中央是一个海水湖,上个世纪在这里形成了一些白色盐矿。鉴于兰萨罗特Salinas de Janubio(Janubio盐田)的这种地貌,我们建议在中央的丘陵上建造一个黑色激进而又引人注目的平面建筑。 展开更多
关键词 萨罗特 平坦区域 火山石 在远方 VOLCANIC LANDSCAPE 遥远的海 ISLAND POWERFUL DISTANT
在线阅读 下载PDF
Using Distant Supervision and Paragraph Vector for Large Scale Relation Extraction 预览
12
作者 Yuming Liu Weiran Xu 《国际计算机前沿大会会议论文集》 2015年第B12期45-47,共3页
Distant supervision has the ability to generate a huge amount training data.Recently,the multi-instance multi-label learning is imported to distant supervision to combat noisy data and improve the performance of relat... Distant supervision has the ability to generate a huge amount training data.Recently,the multi-instance multi-label learning is imported to distant supervision to combat noisy data and improve the performance of relation extraction.But multi-instance multi-label learning only uses hidden variables when inference relation between entities,which could not make full use of training data.Besides,traditional lexical and syntactic features are defective reflecting domain knowledge and global information of sentence,which limits the system’s performance.This paper presents a novel approach for multi-instance multilabel learning,which takes the idea of fuzzy classification.We use cluster center as train-data and in this way we can adequately utilize sentencelevel features.Meanwhile,we extend feature set by paragraph vector,which carries semantic information of sentences.We conduct an extensive empirical study to verify our contributions.The result shows our method is superior to the state-of-the-art distant supervised baseline. 展开更多
关键词 RELATION EXTRACTION DISTANT SUPERVISION PARAGRAPH VECTOR
在线阅读 下载PDF
远距离小切口治疗腋臭效果观察 预览
13
作者 季军 赵天兰 +1 位作者 余道江 于文渊 《中国美容医学》 CAS 2015年第15期10-11,共2页
目的:探讨腋臭小切口位置的优缺点,以改善小切口治疗腋臭中切口愈合的条件。方法:对2008年3月-2014年3月间就医的53例腋臭患者,在腋部外侧非毛区选一小切口,腋臭空心刮匙刮除大汗腺,破坏其导管,手术后加压止血并预防性抗生素治疗。结... 目的:探讨腋臭小切口位置的优缺点,以改善小切口治疗腋臭中切口愈合的条件。方法:对2008年3月-2014年3月间就医的53例腋臭患者,在腋部外侧非毛区选一小切口,腋臭空心刮匙刮除大汗腺,破坏其导管,手术后加压止血并预防性抗生素治疗。结果:53例效果均满意,切口愈合理想。1年内回访效果确切,肩部活动不受限。结论:采用远距离小切口明显降低感染机会,提高切口美观度,且治疗腋臭效果无影响,手术操作简单,值得基层医院推广。 展开更多
关键词 腋臭 远距离 小切口 搔刮
在线阅读 下载PDF
Gall bladder carcinoma:Aggressive malignancy with protean loco-regional and distant spread 预览
14
作者 Amit Nandan Dhar Dwivedi Shivi Jain Ruhi Dixit 《世界临床病例杂志》 2015年第3期231-244,共14页
The most common malignancy of biliary tract is gallbladder cancer(GBC)which is the third most common cancer in gastrointestinal tract.It is a lethal disease for most patients in spite of growing awareness and improved... The most common malignancy of biliary tract is gallbladder cancer(GBC)which is the third most common cancer in gastrointestinal tract.It is a lethal disease for most patients in spite of growing awareness and improved diagnostic techniques.GBC has a very poor prognosis and the 5 year survival rate is<10%.Although etiology of the carcinoma of the gallbladder is still obscure,various factors have been implicated,cholelithiasis being the most frequent.The incidence of GBC worldwide is based on the gender,geography and ethnicity which suggest that both genetic and environmental factors can cause GBC.The major route of spread of gallbladder cancer(GC)is locoregional rather than distant.It spreads by lymphatic,vascular,neural,intraperitoneal,and intraductal routes.Sonography is usually the most common imaging test to evaluate symptoms of biliary tract disease including suspected GC.With recent advances in imaging modalities like multi-detector computed tomography(CT)scanners,magnetic resonance imaging-positron emission tomography/CT diagnosis of gallbladder cancer has improved.Studies have also targeted molecular and genetic pathways.Treatment options have included extended and radical surgeries and adjuvant chemotherapy.This review article deals in detail with important aspects of carcinoma gallbladder and its manifestations and challenges.Role of various imaging modalities in characterization and accurate staging has been discussed.The loco-regional spread of this aggressive malignancy is dealt explicitly. 展开更多
关键词 Gallbladder cancer Loco-regional and DISTANT SPREAD CHOLELITHIASIS Imaging Adenocarcinoma
在线阅读 免费下载
Prognostic value and clinical correlations of18-fluorodeoxyglucose metabolism quantifiers in gastriccancer 预览
15
《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第19期5901-5909,共9页
AIM: To investigate the correlations of pre-treatmentpositron emission tomography-computer tomography(PET-CT) metabolic quantifiers with clinical data ofunstratified gastric cancer (GC) patients.METHODS: Forty P... AIM: To investigate the correlations of pre-treatmentpositron emission tomography-computer tomography(PET-CT) metabolic quantifiers with clinical data ofunstratified gastric cancer (GC) patients.METHODS: Forty PET-CT scans utilising 18-fluorodeoxyglucosein patients who received no prior treatmentwere analysed. Analysis involved measurements ofmaximum and mean standardised uptake volumes(SUV), coefficient of variation (COV), metabolictumour volumes and total lesion glycolysis of differentthresholds above which the tumor volumes wereidentified. The threshold values were: SUV absolutevalue of 2.5, 30% of SUVmax, 40% of SUVmax,and liver uptake-based (marked 2.5, 30, 40 and liv,respectively). Clinical variables such as age, sex,clinical stage, performance index, weight loss, tumorhistological type and grade, and CEA and CA19.9 levelswere included in survival analysis. Patients receivedvarious treatment modalities appropriate to theirdisease stage and the outcome was defined by time tometastasis (TTM) and overall survival (OS). Clinical andmetabolic parameters were evaluated by analysis of variance, receiver operating characteristics, univariateKaplan-Meier, and multivariate Cox models. P 〈 0.05was considered statistically significant.RESULTS: Significant differences were observedbetween initially disseminated and non-disseminatedpatients in mean SUV (6.05 vs 4.13, P = 0.008), TLG2.5(802 cm3 vs 226 cm3; P = 0.031), and TLG30 (436 cm3vs 247 cm3, P = 0.018). Higher COV was associatedwith poor tumour differentiation (0.47 for G3 vs0.28 for G1 and G2; P = 0.03). MTV2.5 was positivelycorrelated to patient weight loss (〈 5%, 5%-10%and 〉 10%: 40.4 cm3 vs 123.6 cm3 vs 181.8 cm3,respectively, P = 0.003). In multivariate Cox analysis,TLG30 was prognostic for OS (HR = 1.001, 95%CI:1.0009-1.0017; P = 0.047) for the whole group ofpatients. In the same model yet only including patientswithout initial disease dissemination TLG30 (HR = 1.009,95%CI: 1.003-1.014; 展开更多
关键词 STOMACH neoplasmas Positron-emissiontomography 18Fluorodeoxyglucose NEOPLASM STAGING DISTANT metastasis
在线阅读 免费下载
Effect of electric acupuncture on the expression of NgR in the cerebral cortex,the medulla oblongata,and the spinal cord of hypertensive rats after cerebral infarction
16
作者 谭峰 《中国医学文摘:内科学分册(英文版)》 2014年第2期74-75,共2页
Objective To observe the effect of electric acupuncture(EA)on the Nogo receptors(NgR)protein expression in the cerebral cortex,the medulla oblongata,and the spinal cord of cerebral ischemia-reperfusion(I/R)stroke-pro... Objective To observe the effect of electric acupuncture(EA)on the Nogo receptors(NgR)protein expression in the cerebral cortex,the medulla oblongata,and the spinal cord of cerebral ischemia-reperfusion(I/R)stroke-prone renovascular hypertensive rats(RHRSP)with middle cerebral artery occlusion(MCAO)at different time points,and to investigate its possible mecha- 展开更多
关键词 HYPERTENSIVE acupuncture cortex ACUPOINT PRONE occlusion Nogo pression DISTANT protective
Surgical strategies in the therapy of non-small cell lung cancer 预览
17
作者 Feras Al-Shahrabani Daniel Vallbohmer +1 位作者 Sebastian Angenendt Wolfram T Knoefel 《世界临床肿瘤学杂志》 2014年第4期595-603,共9页
Lung cancer represents the leading cause of cancer mortality worldwide.Despite improvements in preoperative staging,surgical techniques,neoadjuvant/adjuvant options and postoperative care,there are still major difficu... Lung cancer represents the leading cause of cancer mortality worldwide.Despite improvements in preoperative staging,surgical techniques,neoadjuvant/adjuvant options and postoperative care,there are still major difficulties in significantly improving survival,especially in locally advanced non-small cell lung cancer(NSCLC).To date,surgical resection is the primary mode of treatment for stageⅠandⅡNSCLC and has become an important component of the multimodality therapy of even more advanced disease with a curative intention.In fact,in NSCLC patients with solitary distant metastases,surgical interventions have been discussed in the last years.Accordingly,this review displays the recent surgical strategies implemented in the therapy of NSCLC patients. 展开更多
关键词 NON-SMALL cell lung cancer MULTIMODALITY THERAPY SURGICAL techniques Neoadjuvant/adjuvant THERAPY Solitary DISTANT metastases
在线阅读 免费下载
加拿大风光
18
作者 Lisa.Yu 《走向世界》 2014年第38期90-95,共6页
旅居加拿大的十几年间,我生活在如画风景中,却不自知。一次偶然的机会,我接触到摄影这门艺术,它仿佛为我打开了一扇窗,让我看到了曾经忽视的美丽。学习摄影的过程,也是寻找美、发现美、呈现美的过程。我乐在其中,并享受它带给我的点滴... 旅居加拿大的十几年间,我生活在如画风景中,却不自知。一次偶然的机会,我接触到摄影这门艺术,它仿佛为我打开了一扇窗,让我看到了曾经忽视的美丽。学习摄影的过程,也是寻找美、发现美、呈现美的过程。我乐在其中,并享受它带给我的点滴美好。我很幸运,能用摄影来点缀生活、丰富人生,而不枉度时光。 展开更多
关键词 发现美 加拿大人 景中 PHOTOGRAPHY RAILWAY 蓝鹤 休闲区 BEAUTY QUIET DISTANT
Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer 预览
19
作者 Tokujiro Yano Tatsuro Okamoto +1 位作者 Seiichi Fukuyama Yoshihiko Maehara 《世界临床肿瘤学杂志》 2014年第5期1048-1054,共7页
Postoperative recurrence occurs in approximately half of patients with non-small cell lung cancer(NSCLC),even after complete resection.Disease recurrence after surgical resection reduces the patient’s life expectancy... Postoperative recurrence occurs in approximately half of patients with non-small cell lung cancer(NSCLC),even after complete resection.Disease recurrence after surgical resection reduces the patient’s life expectancy sharply.The prognosis after postoperative recurrence is considered to largely depend on both the mode of first recurrence(distant,locoregional or combined)and the treatment modality:(1)The majority of cases of postoperative recurrence involve distant metastasis with or without locoregional recurrence.Platinum-based systemic chemotherapy is practically accepted as the treatment for these diseases on the basis of evidence for original stageⅣdisease.The advent of both pemetrexed and molecular-targeted drugs has improved the survival of nonsquamous NSCLC and changed the chemotherapeutic algorithm for NSCLC;(2)Among patients with distant metastatic recurrence without locoregional recurrence at the primary tumor site,the metastasis is often limited in both organ and number.Such metastases are referred to as oligometastases.Local therapy,such as surgical resection and radiotherapy,has been suggested to be the first-line treatment of choice for oligometastatic recurrence;and(3)While locoregional recurrence is likely to cause troublesome symptoms,it is a potentially limited disease.Therefore,providing local control is important,and radiation is usually beneficial for treating local recurrence.In order to obtain better control of the disease and provide treatment with curative intent in patients with limited disease,the administration of concurrent platinum-based chemoradiotherapy is recommended according to the results of originally nonresectable stageⅢA andⅢB disease. 展开更多
关键词 NON-SMALL cell lung cancer POSTOPERATIVE RECURRENCE DISTANT metastasis OLIGOMETASTASES Local treatment LOCOREGIONAL RECURRENCE
在线阅读 免费下载
面向远程自主学习的网络课程教学设计研究一以《Photoshop图像处理》课程为例 预览 被引量:3
20
作者 朱世美 房晓东 《中国医学教育技术》 2014年第1期32-35,共4页
网络课程有三种应用目标:面向课堂教学、面向远程自主学习、面向混合式学习。面向远程自主学习的网络课程教学设计以学习者为中心,包含学习资源设计、学习活动设计、学习支持设计、学习评价设计四个最基本的要素。文章结合《Photosho... 网络课程有三种应用目标:面向课堂教学、面向远程自主学习、面向混合式学习。面向远程自主学习的网络课程教学设计以学习者为中心,包含学习资源设计、学习活动设计、学习支持设计、学习评价设计四个最基本的要素。文章结合《Photoshop图像处理》网络课程的教学实践,对以上四个网络课程教学设计要素进行了分析,期望对网络课程教学设计提供借鉴与启发,促进自主学习效果。 展开更多
关键词 远程 自主学习 网络课程 教学设计
在线阅读 下载PDF
上一页 1 2 82 下一页 到第
使用帮助 返回顶部 意见反馈