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文章速递Factors Affecting Disease Risk Perception and Self-Management Behaviors among Japanese Long-Term Overseas Volunteers 认领
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作者 Kiriko Sasayama Stuart Gilmour Erika Ota 《健康(英文)》 2021年第1期16-30,共15页
<strong>Introduction:</strong> Many overseas volunteers have worked in low and middle-income countries. However traveling abroad and staying in an unfamiliar environment with inadequate medical infrastruct... <strong>Introduction:</strong> Many overseas volunteers have worked in low and middle-income countries. However traveling abroad and staying in an unfamiliar environment with inadequate medical infrastructure exposes volunteers to a wide range of health risks. The aim of this study was to clarify the relationships among disease knowledge and symptoms, disease risk perception, and self-management skills. <strong>Methods:</strong> This was a questionnaire survey of 189 Japanese who were preparing to volunteer abroad. A factor analysis was conducted on 13 items (six general risk events and seven major diseases) of risk perception. Correlation analysis was performed between the identified risk perception factors and disease knowledge and symptoms. Risk perception scores by factors from the seven disease items were compared between the Self-management Score (SMS) group and disease knowledge and risk of symptoms group, using T-tests. St. Luke’s International University Ethics Committee (19-A092) approved this study. <strong>Results:</strong> Many participants expected to suffer from digestive diseases (69.3%) and dermatitis (55%) in the field. On the other hand, few expected high risk of malaria (26.5%) or dengue fever (36%). Factor analysis yielded robust factor loadings creating a “Dread” and an “Unknown” factor accounting for 62.2% of total variance. Strong correlation was not found between SMS and disease risk perception. A weak negative correlation was observed in dengue fever, digestive disorders, and dermatitis (r = <span style="white-space:nowrap;">&minus;</span>0.20 to <span style="white-space:nowrap;">&minus;</span>0.25, p < 0.001) on the “Unknown” factor. A high SMS score was associated with a lower “Unknown” factor score for malaria, diarrhea, dermatitis, and dental disorders. In addition, higher disease knowledge was significantly associated with higher “Dread” factor score for dental disorders. <strong>Conclusions: </strong>Self-management skills and disease knowledge will enable higher risk awareness of common diseases and high lethality diseases. 展开更多
关键词 Overseas Volunteers Risk Perception Self-Management-Skills Travel-Related Diseases
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Astrocytes: a double-edged sword in neurodegenerative diseases 认领
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作者 Zhi-Bin Ding Li-Juan Song +3 位作者 Qing Wang Gajendra Kumar Yu-Qing Yan Cun-Gen Ma 《中国神经再生研究:英文版》 SCIE CAS 2021年第9期1702-1710,共9页
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects. ... Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects. Astrocytes become activated as a result of inflammatory responses during the progression of pathological changes associated with neurodegenerative disorders. Reactive astrocytes(neurotoxic A1 and neuroprotective A2) are triggered during disease progression and pathogenesis due to neuroinflammation and ischemia. However, only a limited body of literature describes morphological and functional changes of astrocytes during the progression of neurodegenerative diseases. The present review investigated the detrimental and beneficial roles of astrocytes in neurodegenerative diseases reported in recent studies, as these cells have promising therapeutic potential and offer new approaches for treatment of neurodegenerative diseases. 展开更多
关键词 A1 A2 ASTROCYTES neurodegenerative diseases NEUROINFLAMMATION NEURON NEUROPROTECTION NEUROTOXICITY polarization REACTIVITY
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Fused in sarcoma-amyotrophic lateral sclerosis as a novel member of DNA single strand break diseases with pure neurological phenotypes 认领
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作者 Marcel Naumann Julian Laubenthal Andreas Hermann 《中国神经再生研究:英文版》 SCIE CAS 2021年第1期110-112,共3页
Accumulation of DNA damage and genomic instability are believed to have crucial effects in neurodegenerative conditions such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,premature aging diseases ... Accumulation of DNA damage and genomic instability are believed to have crucial effects in neurodegenerative conditions such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,premature aging diseases as well as amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD).Until recently these studies were largely correlative in nature,though raising the possibility that defects in the DNA damage response(DDR)underlie neurodegenerative diseases. 展开更多
关键词 DISEASES HUNTINGTON amyotrophic
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Neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome 认领
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作者 Ricardo Usategui-Martín Ivan Fernandez-Bueno 《中国神经再生研究:英文版》 SCIE CAS 2021年第1期117-118,共2页
Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness worldwide.It had been es... Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness worldwide.It had been estimated that the prevalence of these diseases varies between 1/750 and 1/5000 depending on the region,the level of consanguinity or ethnicity(Na et al.,2017).The functional and structural complexity of the retina makes it susceptible to multiple types of pathogenic damage. 展开更多
关键词 DISEASES protective DEGENERATIVE
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Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases:Progress and prospect 认领
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作者 Jie Shi Yu-Chen Zhao +5 位作者 Zhi-Fang Niu Hao-Jun Fan Shi-Ke Hou Xiao-Qin Guo Lu Sang Qi Lv 《世界干细胞杂志:英文版(电子版)》 SCIE CAS 2021年第1期49-63,共15页
Mesenchymal stem cells(MSCs)are self-renewing,multipotent cells that could differentiate into multiple tissues.MSC-based therapy has become an attractive and promising strategy for treating human diseases through immu... Mesenchymal stem cells(MSCs)are self-renewing,multipotent cells that could differentiate into multiple tissues.MSC-based therapy has become an attractive and promising strategy for treating human diseases through immune regulation and tissue repair.However,accumulating data have indicated that MSC-based therapeutic effects are mainly attributed to the properties of the MSC-sourced secretome,especially small extracellular vesicles(sEVs).sEVs are signaling vehicles in intercellular communication in normal or pathological conditions.sEVs contain natural contents,such as proteins,mRNA,and microRNAs,and transfer these functional contents to adjacent cells or distant cells through the circulatory system.MSC-sEVs have drawn much attention as attractive agents for treating multiple diseases.The properties of MSC-sEVs include stability in circulation,good biocompatibility,and low toxicity and immunogenicity.Moreover,emerging evidence has shown that MSC-sEVs have equal or even better treatment efficacies than MSCs in many kinds of disease.This review summarizes the current research efforts on the use of MSC-sEVs in the treatment of human diseases and the existing challenges in their application from lab to clinical practice that need to be considered. 展开更多
关键词 Mesenchymal stem cells Small extracellular vesicles EXOSOMES Human diseases THERAPEUTICS PROSPECTS
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Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis 认领
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作者 Francisco J.Barrantes 《中国神经再生研究:英文版》 SCIE CAS 2021年第2期242-246,共5页
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles.The classical form of this autoimmune disease is characterized by the presence of antibodies against the m... Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles.The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction,the nicotinic acetylcholine receptor.Other variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral synapse.This review summarizes the participation of the above proteins in building the neuromuscular junction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia gravis.The review also covers the application of a powerful biophysical technique,superresolution optical microscopy,to image the nicotinic receptor in live cells and follow its motional dynamics.The hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor,as observed in myasthenia gravis. 展开更多
关键词 AGRIN autoimmune diseases muscle end-plate muscle specific kinase MuSK myasthenia gravis NANOSCOPY neuromuscular junction nicotinic acetylcholine receptor RAPSYN superresolution microscopy
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Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols 认领
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作者 Stefania Crispi Stefania Filosa 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1411-1412,共2页
Neurodegenerative diseases are becoming a big challenge for modern society.Neurodegenerative disorders strongly impact on patient and their caregivers.Moreover, since the population is becoming older, these pathologie... Neurodegenerative diseases are becoming a big challenge for modern society.Neurodegenerative disorders strongly impact on patient and their caregivers.Moreover, since the population is becoming older, these pathologies will deeply influence medical and socio-economic conditions in the next years.Therefore, efforts are needed to find new strategies devoted to define new protocols and identify novel substances able to prevent neurodegeneration or to improve the quality of life of people affected by neurodegenerative diseases(Alzheimer's Disease International, 2019). 展开更多
关键词 PREVENTION DISEASES NEURODEGENERATION
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热量限制对健康、衰老和疾病机体肠道菌群影响的研究进展 认领
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作者 叶佳美 钟冬灵 +3 位作者 李涓 张惠玲 金荣疆 张安仁 《中国全科医学》 CAS 北大核心 2021年第7期895-900,共6页
热量限制可以促进机体健康、延长寿命、延缓衰老、防止代谢紊乱和与年龄相关疾病的发生发展。近年来,研究发现肠道菌群在宿主的健康、衰老和疾病中均发挥了关键作用,饮食的改变可显著影响肠道有益菌和致病菌的平衡。热量限制是最常采用... 热量限制可以促进机体健康、延长寿命、延缓衰老、防止代谢紊乱和与年龄相关疾病的发生发展。近年来,研究发现肠道菌群在宿主的健康、衰老和疾病中均发挥了关键作用,饮食的改变可显著影响肠道有益菌和致病菌的平衡。热量限制是最常采用的饮食干预疗法之一,其有益作用可能是通过肠道菌群介导的。本文通过综述热量限制对健康、衰老和疾病状态下机体肠道菌群影响的相关研究进展,以期为热量限制的临床应用和推广提供微生物学证据。 展开更多
关键词 热量限制 肠道菌群 健康 衰老 疾病 综述
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Why use pre-differentiated cells to address complex multi-factorial neurodegenerative diseases? 认领
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作者 Alex Kopyov Toni L.Uhlendorf Randy W.Cohen 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1413-1414,共2页
Past four decades have seen a concerted push to develop regenerative treatments for incurable neurodegenerative diseases such as Parkinson's disease(PD).PD's pathophysiology is primarily characterized by dopam... Past four decades have seen a concerted push to develop regenerative treatments for incurable neurodegenerative diseases such as Parkinson's disease(PD).PD's pathophysiology is primarily characterized by dopamine deficiency caused by the progressive depletion of neurons in substantia nigra(Bernheimer et al., 1973). 展开更多
关键词 DISEASES DEGENERATIVE al.
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Metabolomic profiling provides new insights into blood-brain barrier regulation 认领
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作者 Sheng-Fu Huang Omolara O.Ogunshola 《中国神经再生研究:英文版》 SCIE CAS 2021年第9期1786-1787,共2页
Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbo... Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbott et al., 2010). 展开更多
关键词 Metab al. DISEASES
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Current application and future directions of photobiomodulation in central nervous diseases 认领
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作者 Muyue Yang Zhen Yang +1 位作者 Pu Wang Zhihui Sun 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1177-1185,共9页
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions.Photobiomodulation can promote neurogenesis and elici... Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions.Photobiomodulation can promote neurogenesis and elicit anti-apoptotic,antiinflammatory and antioxidative responses.Its therapeutic effects have been demonstrated in studies on neurological diseases,peripheral nerve injuries,pain relief and wound healing.We conducted a comprehensive literature review of the application of photobiomodulation in patients with central nervous system diseases in February 2019.The NCBI PubMed database,EMBASE database,Cochrane Library and ScienceDirect database were searched.We reviewed 95 papers and analyzed.Photobiomodulation has wide applicability in the treatment of stroke,traumatic brain injury,Parkinson’s disease,Alzheimer’s disease,major depressive disorder,and other diseases.Our analysis provides preliminary evidence that PBM is an effective therapeutic tool for the treatment of central nervous system diseases.However,additional studies with adequate sample size are needed to optimize treatment parameters. 展开更多
关键词 Alzheimer’s disease central nervous system diseases major depressive disorder Parkinson’s disease PHOTOBIOMODULATION STROKE traumatic brain injury
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早产儿动脉导管未闭的治疗进展 认领
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作者 赵颖 田秀英 +1 位作者 边希云 张婉娴 《天津医药》 CAS 北大核心 2021年第1期103-107,共5页
动脉导管未闭(PDA)是严重影响新生儿尤其是早产儿存活及生存质量的一种疾病。目前针对PDA的治疗仍存在很大争议。本文介绍了近年来关于PDA的治疗时机选择、治疗方式(内科治疗、手术结扎及预防性治疗)及药物选择(吲哚美辛、布洛芬及对乙... 动脉导管未闭(PDA)是严重影响新生儿尤其是早产儿存活及生存质量的一种疾病。目前针对PDA的治疗仍存在很大争议。本文介绍了近年来关于PDA的治疗时机选择、治疗方式(内科治疗、手术结扎及预防性治疗)及药物选择(吲哚美辛、布洛芬及对乙酰氨基酚)的研究进展,并对其利弊进行分析。 展开更多
关键词 动脉导管未闭 吲哚美辛 布洛芬 醋氨酚 结扎术 婴儿 新生 疾病
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The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease? 认领
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作者 Vanessa Castelli Michele d’Angelo +3 位作者 Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini 《中国神经再生研究:英文版》 SCIE CAS 2021年第4期628-634,共7页
Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which... Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. 展开更多
关键词 age-related diseases brain DYSBIOSIS gut-brain axis MICROBIOTA NEURODEGENERATION NUTRACEUTICALS Parkinson’s disease PROBIOTICS SLAB51
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Hippo signaling:bridging the gap between cancer and neurodegenerative disorders 认领
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作者 Neha Gogia Anuradha Venkatakrishnan Chimata +2 位作者 Prajakta Deshpande Aditi Singh Amit Singh 《中国神经再生研究:英文版》 SCIE CAS 2021年第4期643-652,共10页
During development,regulation of organ size requires a balance between cell proliferation,growth and cell death.Dysregulation of these fundamental processes can cause a variety of diseases.Excessive cell proliferation... During development,regulation of organ size requires a balance between cell proliferation,growth and cell death.Dysregulation of these fundamental processes can cause a variety of diseases.Excessive cell proliferation results in cancer whereas excessive cell death results in neurodegenerative disorders.Many signaling pathways known-to-date have a role in growth regulation.Among them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and development.Neurodegeneration,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to date.During normal development,cell death is required for sculpting of an organ.However,aberrant cell death in neuronal cell population can result in neurodegenerative disorders.Hippo pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging rapidly.This review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo pathway.Understanding Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future. 展开更多
关键词 animal models cell death mechanisms cell-signaling chemical inhibitors Drosophila eye Hippo pathway NEURODEGENERATION neurological diseases therapeutic targets
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晚期早产儿小于胎龄儿围生期呼吸系统并发症的危险因素研究 认领
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作者 袁二伟 郭华贤 +3 位作者 许津莉 赵文慧 赵美林 王玲玲 《中国全科医学》 CAS 北大核心 2021年第5期581-584,602,共5页
背景小于胎龄儿体格发育较适于胎龄儿差,易合并呼吸窘迫综合征、肺部感染、喂养不耐受、脑瘫、生长发育落后等并发症,其中晚期早产儿小于胎龄儿的呼吸系统疾病发生率显著高于适于胎龄儿,而关于晚期早产儿小于胎龄儿围生期呼吸系统并发... 背景小于胎龄儿体格发育较适于胎龄儿差,易合并呼吸窘迫综合征、肺部感染、喂养不耐受、脑瘫、生长发育落后等并发症,其中晚期早产儿小于胎龄儿的呼吸系统疾病发生率显著高于适于胎龄儿,而关于晚期早产儿小于胎龄儿围生期呼吸系统并发症危险因素的相关研究目前相对较少。目的探讨晚期早产儿小于胎龄儿围生期呼吸系统并发症发生情况及其相关危险因素。方法选取河北北方学院附属第一医院2015年1月-2017年1月收治的100例晚期早产儿(剔除大于胎龄儿)的临床资料进行回顾分析。根据新生儿出生时体质量分为小于胎龄儿组(n=45)和适于胎龄儿组(n=55),比较两组呼吸系统并发症的发生情况。另根据小于胎龄儿组中是否发生呼吸系统并发症分为疾病亚组(n=28)和非疾病亚组(n=17),对母亲和新生儿可能的相关因素进行单因素分析。采用多因素Logistic回归分析晚期早产儿小于胎龄儿围生期呼吸系统并发症的危险因素。结果小于胎龄儿组围生期呼吸系统并发症发生率高于适于胎龄儿组(62.2%与41.8%,χ2=4.122,P<0.05)。疾病亚组母亲相关因素中妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、胎盘早剥发生率及新生儿相关因素中脓毒症发生率高于非疾病亚组(P<0.05)。多因素Logistic回归分析显示,妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、新生儿脓毒症为发生呼吸系统并发症的危险因素(P<0.05)。结论晚期早产儿小于胎龄儿围生期呼吸系统并发症发生率高于适于胎龄儿,妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、新生儿脓毒症是引起晚期早产儿小于胎龄儿围生期呼吸系统并发症的高危因素。 展开更多
关键词 婴儿 早产 疾病 晚期早产儿 婴儿 小于胎龄 呼吸系统并发症 危险因素
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Polyglutamine diseases: looking beyond the neurodegenerative universe 认领
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作者 Michal Mielcarek Mark Isalan 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1186-1187,共2页
Multisystem disorders are often manifested by affecting more than one bodily system or tissue.We have recently reported a significantly higher prevalence of coexisting conditions in the cohorts of both pre-and symptom... Multisystem disorders are often manifested by affecting more than one bodily system or tissue.We have recently reported a significantly higher prevalence of coexisting conditions in the cohorts of both pre-and symptomatic Huntington’s disease(HD)gene carriers.We reported that even pre-symptomatic HD patients had a significantly higher number of comorbid conditions,while the symptomatic group of HD patients was characterized by a significantly lower percentage of subjects without any comorbidity(7%)in comparison to the control group(50%). 展开更多
关键词 HUNTINGTON DISEASES patients
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Microglia-oligodendrocyte intercellular communication: role of extracellular vesicle lipids in functional signalling 认领
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作者 Alice Gualerzi Marta Lombardi Claudia Verderio 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1194-1195,共2页
The term microglia refers to the group of resident brain immune-cells that are responsible,mainly,for the immune response and the homeostasis of the brain.Unlike monocyte-derived macrophages that infiltrate the brain,... The term microglia refers to the group of resident brain immune-cells that are responsible,mainly,for the immune response and the homeostasis of the brain.Unlike monocyte-derived macrophages that infiltrate the brain,microglia are longlived cells which arise exclusively from the embryonic yolk sac(Stratoulias et al.,2019).Impairment in microglia functions is at the basis for the development of multiple brain diseases,including multiple sclerosis and neurodegenerative diseases.In the last decade,the number of research articles and reviews dealing with the role of microglia in the pathogenesis of brain disorders has exponentially increased. 展开更多
关键词 al. HOMEOSTASIS diseases
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Oligodendrocytes in a dish for the drug discovery pipeline:the risk of oversimplification 认领
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作者 Vito Antonio Baldassarro Luciana Giardino Laura Calzà 《中国神经再生研究:英文版》 SCIE CAS 2021年第2期291-293,共3页
Myelination,remyelination and demyelination:modeling the in vitro drug discovery pipeline:Demyelination is a multifactorial event occurring in diseases primarily involving myelin forming cells(oligodendrocytes,OLs)and... Myelination,remyelination and demyelination:modeling the in vitro drug discovery pipeline:Demyelination is a multifactorial event occurring in diseases primarily involving myelin forming cells(oligodendrocytes,OLs)and their precursors(oligodendrocyte precursor cells,OPCs)such as multiple sclerosis,but is also involved in the pathology of other central nervous system(CNS)injuries and diseases,such as neonatal encephalopathy。 展开更多
关键词 cytes INJURIES DISEASES
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Implications of Withaferin A in neurological disorders 认领
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作者 Natasha Ram Stephanie L.Peak +1 位作者 Andres R.Perez Umesh K.Jinwal 《中国神经再生研究:英文版》 SCIE CAS 2021年第2期304-305,共2页
Extract from the medicinal herb Withania somnifera(WS),commonly known as Ashwagandha,has therapeutic implications in various conditions such as infection,inflammation,cancer,stress,neurodegenerative diseases,heart dis... Extract from the medicinal herb Withania somnifera(WS),commonly known as Ashwagandha,has therapeutic implications in various conditions such as infection,inflammation,cancer,stress,neurodegenerative diseases,heart disease,diabetes,and others.Withaferin A(WA)。 展开更多
关键词 INFLAMMATION DISEASES INFECTION
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The inducible nitric oxide synthaseinhibitor 1400W as a potential treatment for retinal diseases 认领
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作者 Sven Schnichels Stephanie C.Joachim 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1221-1222,共2页
The overproduction of reactive oxygen species is defined as oxidative stress.While deprived oxygen supply in tissues is known as hypoxia.These mechanisms contribute to the pathogenesis of several retinal diseases,like... The overproduction of reactive oxygen species is defined as oxidative stress.While deprived oxygen supply in tissues is known as hypoxia.These mechanisms contribute to the pathogenesis of several retinal diseases,like glaucoma,age-related macular degeneration(AMD),and retinal ischemia.Glaucoma is a neurodegenerative disease defined by a progressive loss of retinal ganglion cells(RGCs)and their axons causing visual field defects,which ultimately leads to blindness.While AMD pathogenesis is further characterized by soft drusen,it involves the retinal pigment epithelium and the Bruch’s membrane-choroid complex. 展开更多
关键词 AMD DISEASES POTENTIAL
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