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Early immune response in post endoscopic retrograde cholangiopancreatography pancreatitis as a model for acute pancreatitis 预览
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作者 Ivana Plavsic Ivana Zitinic +3 位作者 Vera Tulic Goran Poropat Marinko Marusic Goran Hauser 《世界荟萃分析杂志》 2019年第3期96-100,共5页
This opinion review summarizes comparison of clinical presentation and immunology of post-endoscopic pancreatitis and acute pancreatitis (AP) of other etiology. The rationale for this topic was found in studies that m... This opinion review summarizes comparison of clinical presentation and immunology of post-endoscopic pancreatitis and acute pancreatitis (AP) of other etiology. The rationale for this topic was found in studies that mention differences in clinical presentation between these entities, stating that severe form of AP after endoscopic retrograde cholangiopancreatography was more severe than AP of other etiology. Found difference in clinical presentation may have a background in different immunology that needs to be further investigated. 展开更多
关键词 INNATE immunity PANCREATITIS IMMUNOLOGY POST endoscopic retrograde CHOLANGIOPANCREATOGRAPHY PANCREATITIS
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Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter
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作者 Donghao Sun Xuetao Cao Chunmei Wang 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2019年第4期285-294,共10页
Polycomb chromobox(CBX)proteins regulate gene transcription by maintaining chromatin states,which guide a variety of biological processes.Now,epigenetic regulation of innate immune response is an emerging field.Howeve... Polycomb chromobox(CBX)proteins regulate gene transcription by maintaining chromatin states,which guide a variety of biological processes.Now,epigenetic regulation of innate immune response is an emerging field.However,the role of CBX proteins in innate immunity remains unclear.We confirmed that the expression of CBX family proteins,especially Cbx2,was decreased in macrophages upon viral infection,and then we investigated the role of Cbx2 in the antiviral immune response.Silencing or knockdown of Cbx2 in macrophages inhibited virus-induced production of IFNp.Furthermore,heterozygous Cbx2 knockout were susceptible to VSV challenge.Mechanistically,Cbx2 binds to and recruits Jmjd3 to the Ifnb promoter,leading to demethylation of H3K27me3 and increased transcription of IFN-β.Together,our study reveals a nontraditional function of a Cbx protein and adds new insight into the epigenetic regulation of antiviral innate immunity. 展开更多
关键词 Cbx2 Jmjd3 INTERFERON beta INNATE immunity
Chimeric antigen receptor engineered innate immune cells in cancer immunotherapy
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作者 Chu Lin Jun Zhang 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第5期633-639,共7页
Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovation in cancer immunotherapy. As an important type of adaptive immune cells, T cells first caught r... Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovation in cancer immunotherapy. As an important type of adaptive immune cells, T cells first caught researchers’ attention and became great success in chimeric antigen receptor-based immunotherapy. However, engineered T cells seem to hit their bottleneck when resistance of cancerous cells, less encouraging responses in solid tumors and unwanted toxicities to the host remain to be solved.Meanwhile, innate immune cells get to join the race. Representatives such as natural killer cells, natural killer T cells, γδT cells and macrophages also prove to be well redirected with chimeric antigen receptors. Compared to chimeric antigen receptor engineered T cells, these engineered innate immune cells may possess multiple targeting and killing mechanisms, have the potential to crack the barrier of solid tumors and have less side effects in the host. Besides, possible universal access to cell resources and improvements in expansion and transduction techniques make these cells promising candidates with huge potential in translational medicine. Therefore, innate immune cells claim a brand-new dimension and are likely to supplement T cells greatly in the field of chimeric antigen receptor-based immunotherapy. 展开更多
关键词 CHIMERIC ANTIGEN RECEPTOR cancer IMMUNOTHERAPY INNATE IMMUNE cell
Effects and mechanisms of innate immune molecules on inhibiting nasopharyngeal carcinoma
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作者 Fang Xiong Su Deng +9 位作者 Hong-Bin Huang Xia-Yu Li Wen-Ling Zhang Qian-Jin Liao Jian Ma Xiao-Ling Li Wei Xiong Gui-Yuan Li Zhao-Yang Zeng Can Guo 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第6期749-752,共4页
To the Editor: The nasopharyngeal ep让helium is frequently exposed to various harmful carcinogens. When the nasopharvngeal mucosa is damaged, local inflammation is induced.[1] Chronic inflammation of the nasopharyngea... To the Editor: The nasopharyngeal ep让helium is frequently exposed to various harmful carcinogens. When the nasopharvngeal mucosa is damaged, local inflammation is induced.[1] Chronic inflammation of the nasopharyngeal epithelium may eventually evolve into nasopharyngeal carcinoma (NPC). While the mucus secreted by the nasopharyngeal epithelium forms the body's primitive immune protection barrier as it contains a series of proteins and peptides that can sense, bind, degrade and remove various harmful substances. Lactotransferrin (LTF)[2] and bactericidal/permeability-increasing (BPI) protein family members[3] are an important component of the innate immune protection barrier. 展开更多
关键词 EFFECTS and MECHANISMS INNATE immune MOLECULES INHIBITING NASOPHARYNGEAL carcinoma
Expression of macrophage migration inhibitory factor in Aspergillus fumigatus keratitis
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作者 Qiang Xu Li-Ting Hu +4 位作者 Qian Wang Jing Lin Nan Jiang Cui Li Gui-Qiu Zhao 《国际眼科杂志:英文版》 SCIE CAS 2019年第5期711-716,共6页
AIM: To investigate the expression of macrophage migration inhibitory factor(MIF) and detect its role in the innate immune response of fungal keratitis(FK). METHODS: We collected the paraffin-embedded cornea tissues f... AIM: To investigate the expression of macrophage migration inhibitory factor(MIF) and detect its role in the innate immune response of fungal keratitis(FK). METHODS: We collected the paraffin-embedded cornea tissues from 10 FK and 6 ocular trauma patients to explore the MIF expression by immunohistochemistry. Then we cultured telomease-immortalized human corneal epithelial cells(THCEs), stimulated by the hyphae suspension of Aspergillus fumigatus(A. fumigatus) to detect the change of MIF with or without the pretreatment of MIF inhibitor [4-Iodo-6-phenylpyrimidine(4-IPP)] by real-time polymerase chain reaction(PCR). The protein level of MIF was also tested by immunohistochemistry, and the level of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) mRNA were compared between normal, hyphae stimulated and 4-IPP pretreated groups by real-time PCR to study the influence of MIF on the expression of TNF-α and IL-6. Corneal severity of rats’ FK models was documented by clinical scores, and real-time PCR. Western blot and immunohistochemistry were used to test the expression of MIF, TNF-α and IL-6 in rats’ corneas.RESULTS: In the corneas of FK patients, there was much stronger expression of MIF than that in the normal group showed by immunohistochemistry. In cultured THCEs stimulated by A. fumigatus, the expression of MIF became stronger in both immunohistochemistry and PCR at 16, 24, 32 and 48 h post infection(p.i.;P<0.01, P<0.01, P<0.01, P<0.05). After pretreated with 4-IPP, the expression of MIF reduced at 4, 8, 16 h p.i.(P<0.05, P<0.05, P<0.05) and the downstream TNF-α and IL-6 decreased obviously(P<0.05, P<0.01). In rats with A. fumigatus keratitis, the relative mRNA and protein level of MIF increased than thosein the normal group by PCR(at 1 d: P<0.01, 3 d: P<0.01, 5 d: P<0.01), Western blot and immunohistochemistry. After blocked MIF with 4-IPP, the clinical outcomes of rat keratitis showed markedly reduced inflammatory response(P<0.01), with TNF-α and IL-6 decreased in accordance with those in THCEs 展开更多
关键词 macrophage migration INHIBITORY factor FUNGAL KERATITIS INNATE immune A. FUMIGATUS CORNEAL epithelial cells rats
A Plant Immune Receptor Adopts a Two-Step Recognition Mechanism to Enhance Viral Effector Perception
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作者 Jia Li Haining Huang +4 位作者 Min Zhu Shen Huang Wenhua Zhang Savithramma P. Dinesh-Kumar Xiaorong Tao 《分子植物:英文版》 SCIE CAS CSCD 2019年第2期248-262,共15页
Plant intracellular nucleotide binding leucine-rich repeat (NLR) immune receptors play critical roles in pathoge n surveillance. Most plant NLRs characterized so far were found to use a single domain/sensor to recogni... Plant intracellular nucleotide binding leucine-rich repeat (NLR) immune receptors play critical roles in pathoge n surveillance. Most plant NLRs characterized so far were found to use a single domain/sensor to recognize pathogen effectors. Here we report that the Sw-5b NLR immune receptor uses two distinct domains to detect the viral movement protein NSm encoded by tospovirus. In addition to its leucine-rich repeat (LRR) domain that has been previously reported, the N-terminal Solanaceae domain (SD) of Sw- 5b also interacts with NSm and a conserved 21-amino-acid region of NSm (NSm^21). The specific interaction between Sw-5b SD and NSm is required for releasing the inhibitory effect of coiled-coil domain on the NBARC- LRR region. Furthermore, we found that the binding of NSm affects the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm^21 levels are high. Interestingly, Sw-5b SD could significantly enhanee the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilitate its activation and induction of defense response. An Sw-5b SD mutant that is disrupted in NSm recognition failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm^21 . Taken together, our results suggest that Sw-5b SD functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two-step recog nition mechanism to enhance viral effector perception. 展开更多
关键词 plant INNATE immunity nucleotide binding leucine-rich repeat (NLR) immune receptors SOLANACEAE domain (SD) pathogen PERCEPTION TWO-STEP recognition defense response
Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates
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作者 Yuming He Hailin Pan +1 位作者 Guojie Zhang Shunping He 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第4期566-578,共13页
Pattern recognition receptors(PRRs)play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns.The main four PRRs components inc... Pattern recognition receptors(PRRs)play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns.The main four PRRs components including Toll-like receptors(TLRs),RIG-I-like receptors(RLRs),NOD-like receptors(NLRs)and C-type lectin receptors(CLRs)were surveyed in the five genomes of non-teleost ray-finned fishes(NTR)including bichir(Polypterus senegalus),American paddlefish(Polyodon spathula),alligator gar(Atractosteus spatula),spotted gar(Lepisosteus oculatus)and bowfin(Amia calva),representing all the four major basal groups of ray-finned fishes.The result indicates that all the four PRRs components have been well established in these NTR fishes.In the RLR-MAVS signal pathway,which detects intracellular RNA ligands to induce production of type I interferons(IFNs),the MAVS was lost in bichir particularly.Also,the essential genes of recognition of Lipopolysaccharide(LPS)commonly in mammals like MD2,LY96 and LBP could not be identified in NTR fishes.It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals.In addition,we provide a survey of NLR and CLR in NTR fishes.The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution.Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate. 展开更多
关键词 pattern recognition receptors(PRR) Toll-like receptors(TLR) RIG-I-like receptors(RLR) C-type lectin receptors(CLR) NOD-like receptors(NLR) innate immunity
Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility
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作者 Paola A. Caicedo Idalba Mildred Serrato +4 位作者 Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第4期635-648,共14页
Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. a... Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DENV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (DENV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti. 展开更多
关键词 AEDES aegypti DENGUE virus INNATE immune response KNOCKDOWN microarray vector competence
Toll样受体在肿瘤治疗中的作用机制及应用前景
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作者 刘偲奇 韩慈 张德凯 《肿瘤》 CAS CSCD 北大核心 2019年第6期508-514,共7页
Toll样受体(Toll-like receptor,TLR)不仅与肿瘤的生长和免疫抑制有关,还与细胞凋亡及免疫系统的激活相关。TLR可以诱导细胞凋亡并激活固有和适应性免疫应答,这些功能都有可能使其成为抗肿瘤治疗的靶点。许多研究和临床试验表明,肿瘤中... Toll样受体(Toll-like receptor,TLR)不仅与肿瘤的生长和免疫抑制有关,还与细胞凋亡及免疫系统的激活相关。TLR可以诱导细胞凋亡并激活固有和适应性免疫应答,这些功能都有可能使其成为抗肿瘤治疗的靶点。许多研究和临床试验表明,肿瘤中TLR的激活可能与肿瘤治疗有关,因此采用TLR激动剂应用于肿瘤治疗有望成为一种新型的临床治疗方式,尤其在放疗或化疗联合进行治疗中。已有多项研究表明,TLR激动剂在肿瘤治疗中具有巨大潜力,因此对于抑制肿瘤发展的TLR信号通路的研究将是现阶段的重中之重。本综述就近期关于TLR在肿瘤中的作用机制、TLR激动剂在抗肿瘤治疗中的临床应用价值及尚需完善的问题进行综述。 展开更多
关键词 肿瘤 TOLL样受体 免疫 先天 抗肿瘤联合化疗方案
异维A酸对肽聚糖诱导的SZ95人皮脂腺细胞相关炎症基因表达的影响
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作者 曹珂 侯霄枭 +2 位作者 李昕 Christos C.Zouboulis 鞠强 《中华皮肤科杂志》 CAS CSCD 北大核心 2019年第4期248-252,共5页
目的观察异维A酸体外对肽聚糖诱导的SZ95人皮脂腺细胞中与痤疮发病可能相关的炎症基因表达的影响,探讨异维A酸治疗痤疮的分子机制。方法将培养的SZ95细胞分成3组,对照组不做处理,另外两组用20mg/L肽聚糖单独(肽聚糖组)或联合10^-5mol/L... 目的观察异维A酸体外对肽聚糖诱导的SZ95人皮脂腺细胞中与痤疮发病可能相关的炎症基因表达的影响,探讨异维A酸治疗痤疮的分子机制。方法将培养的SZ95细胞分成3组,对照组不做处理,另外两组用20mg/L肽聚糖单独(肽聚糖组)或联合10^-5mol/L异维A酸(共刺激组)共同处理。作用3h后,实时荧光定量PCR检测上述各组SZ95细胞中白细胞介素(IL)-1α、IL-1β、IL-6、IL-8、肿瘤坏死因子α(TNF-α)以及Toll样受体2(TLR2)和其下游基因MyD88 mRNA表达水平;作用24h后酶联免疫吸附试验检测各组细胞培养上清液中IL-1α、IL-1β、IL-6、IL-8、TNF-α蛋白表达水平;作用48h后Western印迹检测TLR2和MyD88蛋白表达水平。采用SPSS23软件,3组间指标的比较采用单因素方差分析,并采用Bonferroni校正进行两两比较。结果对照组、肽聚糖组和共刺激组IL-1α、IL-1β、IL-6、IL-8及TNF-αmRNA和蛋白表达水平差异均有统计学意义(均P<0.01);其中,肽聚糖组上述指标均高于对照组及共刺激组,差异均有统计学意义(均P<0.0167)。上述3组间MyD88mRNA表达差异也均有统计学意义(分别为6.707±0.950、10.270±0.477、7.892±0.900,F=10.17,P<0.01),肽聚糖组高于对照组及共刺激组,差异均有统计学意义(t值分别为4.740、3.298,均P<0.0167)。肽聚糖组TLR2 mRNA和蛋白表达水平均高于对照组,但与共刺激组比较差异无统计学意义。结论异维A酸抑制肽聚糖诱导的SZ95人皮脂腺细胞中与痤疮发病可能相关的炎症因子的表达,其机制可能是通过抑制天然免疫应答中MyD88的表达而非TLR2本身,这可能是异维A酸治疗痤疮的机制之一。 展开更多
关键词 寻常痤疮 异维A酸 药理作用分子作用机制 肽聚糖 细胞因子类 TOLL样受体2 免疫 先天 人皮脂腺细胞
Inflammation and cardiovascular disease 预览
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作者 Christina G Katsiari Dimitrios P Bogdanos Lazaros I Sakkas 《世界转化医学杂志》 2019年第1期1-8,共8页
Cardiovascular disease(CVD)has been associated with the so-called traditional risk factors,such as hypertension,hypercholesterolemia and cigarette smoking.Chronic inflammation,exemplified by elevated high sensitivity ... Cardiovascular disease(CVD)has been associated with the so-called traditional risk factors,such as hypertension,hypercholesterolemia and cigarette smoking.Chronic inflammation,exemplified by elevated high sensitivity C-reactive protein,has been added to these risk factors for CVD as non-traditional risk factor.There are two aspects in this association.The first is whether inflammation plays a pathogenic role in traditional risk factors-mediated CVD or it is just an epiphenomenon.The second is whether chronic inflammation caused by an inflammatory disease has any impact on CVD.Accumulated data have shown that inflammation has a central and inciting role in the development of atherosclerosis leading to increased CVD risk.How inflammation contributes to CVD is a topic of continuous research where mechanisms involving both innate and adaptive immune pathways are involved.Endothelial dysfunction,oxidative stress in vascular endothelial cells,macrophage accumulation,formation of inflammasome,production of tumor necrosis factor(TNF)-a,IL-1 and IL-6 characterize the inflammatory process leading to atherogenesis.Recently clonal hematopoiesis of indeterminate potential represents a surprising and novel mechanism underlying atherogenesis.Data from chronic rheumatic inflammatory diseases exemplify the complexity of mechanisms leading to increased CVD,while they also provide evidence that anti-inflammatory biologic drugs,such as anti-TNF and anti-IL6 agents,could control atherogenesis and ameliorate CVD risk.Recent groundbreaking work using biologic anti-IL-1b therapy to treat men and women who have had a prior heart attack provides the best proof of the pathogenic contribution of inflammation in the development of CVD. 展开更多
关键词 Cardiovascular DISEASE Coronary artery DISEASE ATHEROSCLEROSIS INFLAMMATION INNATE IMMUNITY Adaptive IMMUNITY BIOLOGIC drugs
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论儒学人性论的四个维度 预览
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作者 郭小军 《社会科学》 CSSCI 北大核心 2018年第10期125-133,共9页
儒学是一种作为生活方式的哲学,以人为核心,以修身为根本,追求人格的自我完善。作为一种为己之学和成人之道,儒学人性论中蕴涵着不同的面向:天人合一、继善成性的理论架构指向天成性的维度;即用显体、学以成人的工夫进路蕴藏了生... 儒学是一种作为生活方式的哲学,以人为核心,以修身为根本,追求人格的自我完善。作为一种为己之学和成人之道,儒学人性论中蕴涵着不同的面向:天人合一、继善成性的理论架构指向天成性的维度;即用显体、学以成人的工夫进路蕴藏了生成性的维度;仁礼并重、内圣外王的价值系统展现了构成性的维度;机体主义的形上模式、一体之仁的境界追求彰显了圆成性的维度。通过修身,推动自我人格的不断成长与完善,借此获得根源性的能量去转化家国天下,将自我与他者、个体与社群、德性修养与社会治理有机地沟通融合,充分彰显了儒学“一天人,合外内”的深邃意蕴。 展开更多
关键词 儒学 人性 天成性 生成性 构成性 圆成性
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免疫治疗或可实现慢性乙型肝炎的功能性治愈
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作者 祝丹 潘雯 +1 位作者 刘嘉 杨东亮 《中华临床感染病杂志》 2018年第4期261-268,共8页
临床现有的针对慢性HBV感染的抗病毒治疗手段可以有效地控制HBV复制,但在绝大多数患者中仍难以实现HBsAg的清除和安全停药,即慢性乙型肝炎(CHB)的功能性治愈。机体的免疫应答在HBV的清除中起着关键作用,通过激活患者的天然免疫和... 临床现有的针对慢性HBV感染的抗病毒治疗手段可以有效地控制HBV复制,但在绝大多数患者中仍难以实现HBsAg的清除和安全停药,即慢性乙型肝炎(CHB)的功能性治愈。机体的免疫应答在HBV的清除中起着关键作用,通过激活患者的天然免疫和适应性免疫应答有望实现对HBV感染的持续控制,从而显著提高CHB的功能性治愈率。本文对近年来CHB功能性治愈相关的免疫学研究进展进行总结。 展开更多
关键词 肝炎 乙型 慢性 免疫 先天 免疫 体液 适应性免疫 功能性治愈
Influence of Human Papillomavirus E7 Oncoprotein on Maturation and Function of Plasmacytoid Dendritic Cells In Vitro
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作者 Rui Han Yin-Jing Song +4 位作者 Si-Yuan Sun Qiang Zhou Xian-Zhen Chen Qiao-Li Zheng Hao Cheng 《中国病毒学:英文版》 CAS CSCD 2018年第6期493-501,共9页
The major difficulties of human papillomavirus(HPV) treatment are its persistence and recurrence. The HPV E7 oncoprotein-loaded dendritic cells have been evaluated as cellular vaccine in previous reports. Plasmacytoid... The major difficulties of human papillomavirus(HPV) treatment are its persistence and recurrence. The HPV E7 oncoprotein-loaded dendritic cells have been evaluated as cellular vaccine in previous reports. Plasmacytoid dendritic cells(pDCs) play an essential role of connecting the innate immune response and adaptive immune response in the immune system. But they function in HPV E7 loading is unclear. To investigate whether loading of the HPV type 6b, 11, and 16 E7 proteins affects the activity of pDCs, human peripheral blood-separated pDCs and mouse bone marrow-derived pDCs were pulsed with the HPV E7 proteins. The expression levels of CD40, CD80, CD86, and MHC II were significantly upregulated in pDCs upon HPV 6b/11 E7 protein pulse. The secretion and gene expression of type I IFN and IL-6 were both upregulated by HPV 6b/11 E7 proteins, more significant than HPV 16 E7 protein. The expression of essential factors of TLR signaling pathway and JNK/p38 MAP kinase signaling pathway were all increased in HPV 6b/11 E7 proteins pulsed pDCs. Our results suggest that HPV E7 proteins could promote the differentiation and maturation of pDCs and activate the TLR and MAPK pathway to induce host innate immune response. It might be conducive to explore novel immunotherapy targeting HPV infection with HPV E7 loaded pDC. 展开更多
关键词 Human papillomavirus(HPV) PLASMACYTOID dendritic cells(pDCs) TOLL-LIKE receptors(TLRs) INNATE immunity
Hepatitis B virus-persistent infection and innate immunity defect:Cell-related or virus-related? 预览
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作者 Jian Tang Zhen-Yu Wu +2 位作者 Rong-Juan Dai Jing Ma Guo-Zhong Gong 《世界临床病例杂志》 2018年第9期233-241,共9页
The outcomes of hepatitis B virus(HBV)infection are closely related to the age at which infection was acquired.Infection acquired in adult life tends to be selflimited,in contrast to perinatal acquirement,for which ch... The outcomes of hepatitis B virus(HBV)infection are closely related to the age at which infection was acquired.Infection acquired in adult life tends to be selflimited,in contrast to perinatal acquirement,for which chronic persistence of the HBV is a general outcome.Innate immunity plays an indispensable role in early virus infection,facilitating virus clearance.However,it has been reported that HBV is under-recognized and poorly eliminated by the innate immune system in the early stages of infection,possibly explaining the long-lasting persistence of viremia afterwards.Furthermore,due to the existence of covalently closed circular DNA,chronic HBV clearance is very difficult,even when patients are given interferon-αand nucleotide/nucleoside analogs for antiviral therapy.The mechanism by which HBV evades innate immune recognition and establishes persistent infection remains a subject of debate.Besides,some researchers are becoming more interested in how to eradicate chronic HBV infection by restoring or boosting innate immunity.This review aimed to summarize the current knowledge on how intrahepatocyte signaling pathways and innate immune cells act after the onset of HBV infection and how these actions are related to the persistence of HBV.We anticipate the insights presented herein to be helpful for future development of novel immune therapeutic strategies to fight HBV infection. 展开更多
关键词 Hepatitis B virus INNATE immunity Immune EVASION Pattern recognition RECEPTOR TOLL-LIKE RECEPTOR Natural killer CELLS KUPFFER CELLS Dendritic CELLS
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Ambiguous roles of innate lymphoid cells in chronic development of liver diseases 预览
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作者 Yue Shen Jing Li +1 位作者 Si-Qi Wang Wei Jiang 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第18期1962-1977,共16页
Innate lymphoid cells(ILCs)are defined as a distinct arm of innate immunity.According to their profile of secreted cytokines and lineage-specific transcriptional factors,ILCs can be categorized into the following thre... Innate lymphoid cells(ILCs)are defined as a distinct arm of innate immunity.According to their profile of secreted cytokines and lineage-specific transcriptional factors,ILCs can be categorized into the following three groups:group 1 ILCs(including natural killer(NK)cells and ILC1s)are dependent on T-bet and can produce interferon-γ;group 2 ILCs(ILC2s)are dependent on GATA3 and can produce type 2 cytokines,including interleukin(IL)-5 and IL-13;and,group 3 ILCs(including lymphoid tissue-like cells and ILC3s)are dependent on RORγt and can produce IL-22 and IL-17.Collaborative with adaptive immunity,ILCs are highly reactive innate effectors that promptly orchestrate immunity,inflammation and tissue repair.Dysregulation of ILCs might result in inflammatory disorders.Evidence regarding the function of intrahepatic ILCs is emerging from longitudinal studies of inflammatory liver diseases wherein they exert both physiological and pathological functions,including immune homeostasis,defenses and surveillance.Their overall effect on the liver depends on the balance of their proinflammatory and antiinflammatory populations,specific microenvironment and stages of immune responses.Here,we review the current data about ILCs in chronic liver disease progression,to reveal their roles in different stages as well as to discuss their therapeutic potency as intervention targets. 展开更多
关键词 INNATE LYMPHOID cells CHRONIC LIVER disease Hepatitis LIVER FIBROSIS LIVER cancer
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Targeting tumor cells with antibodies enhances anti-tumor immunity
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作者 Zhichen Sun Yang-Xin FU Hua Peng 《生物物理学报:英文版》 CSCD 2018年第5期243-253,共11页
Tumor-targeting antibodies were initially defined as a group of therapeutic monoclonal antibodies (mAb)that recognize tumor-specific membrane proteins,block cell signaling,and induce tumor-killing through Fc-driven in... Tumor-targeting antibodies were initially defined as a group of therapeutic monoclonal antibodies (mAb)that recognize tumor-specific membrane proteins,block cell signaling,and induce tumor-killing through Fc-driven innate immune responses.However,in the past decade,ample evidence has shown that tumor-targeting mAb (TTmAb)eradicates tumor cells via activation of cytotoxic T cells (CTLs).In this review,we specifically focus on how TTmAbs induce adaptive anti-tumor immunity and its potential in combination therapy with immune cytokines,checkpoint blockade,radiation,and enzymetargeted small molecule drugs.Exploring the mechanisms of these preclinical studies and retrospective clinical data will significantly benefit the development of highly efficient and specific TTmAb-oriented anti-tumor remedies. 展开更多
关键词 TUMOR antigen TARGETING antibody INNATE IMMUNITY Adaptive IMMUNITY Cytokine TUMOR MICROENVIRONMENT
Old game,new players:Linking classical theories to new trends in transplant immunology 预览
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作者 Marina Burgos da Silva Flavia Franco da Cunha +1 位作者 Fernanda Fernandes Terra Niels Olsen Saraiva Camara 《世界移植杂志》 2017年第1期1-25,共25页
The evolutionary emergence of an efficient immune system has a fundamental role in our survival against pathogenic attacks.Nevertheless,this same protective mechanism may also establish a negative consequence in the s... The evolutionary emergence of an efficient immune system has a fundamental role in our survival against pathogenic attacks.Nevertheless,this same protective mechanism may also establish a negative consequence in the setting of disorders such as autoimmunity and transplant rejection.In light of the latter,although research has long uncovered main concepts of allogeneic recognition,immune rejection is still the main obstacle to long-term graft survival.Therefore,in order to define effective therapies that prolong graft viability,it is essential that we understand the underlying mediators and mechanisms that participate in transplant rejection.This multifaceted process is characterized by diverse cellular and humoral participants with innate and adaptive functions that can determine the type of rejection or promote graft acceptance.Although a number of mediators of graft recognition have been described in traditional immunology,recent studies indicate that defining rigid roles for certain immune cells and factors may be more complicated than originally conceived.Current research has also targeted specific cells and drugs that regulate immune activation and induce tolerance.This review will give a broad view of the most recent understanding of the allogeneic inflammatory/tolerogenic response and current insights into cellular and drug therapies that modulate immune activation that may prove to be useful in the induction of tolerance in the clinical setting. 展开更多
关键词 TRANSPLANT IMMUNOLOGY Immune REJECTION Inflammation Adaptive IMMUNITY INNATE IMMUNITY Graft tolerance
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Yersinia type Ⅲ effectors perturb host innate immune responses 预览
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作者 Khavong Pha Lorena Navarro 《世界生物化学杂志:英文版(电子版)》 2016年第1期1-13,共13页
The innate immune system is the first line of defense against invading pathogens. Innate immune cells recognize molecular patterns from the pathogen and mount a response to resolve the infection. The production of pro... The innate immune system is the first line of defense against invading pathogens. Innate immune cells recognize molecular patterns from the pathogen and mount a response to resolve the infection. The production of proinflammatory cytokines and reactive oxygen species, phagocytosis, and induced programmed cell death are processes initiated by innate immune cells in order to combat invading pathogens. However, pathogens have evolved various virulence mechanisms to subvert these responses. One strategy utilized by Gram-negative bacterial pathogens is the deployment of a complex machine termed the type Ⅲ secretion system(T3SS). The T3SS is composed of a syringe-like needle structure and the effector proteins that are injected directly into a target host cell to disrupt a cellular response. The three human pathogenic Yersinia spp.(Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis) are Gramnegative bacteria that share in common a 70 kb virulence plasmid which encodes the T3 SS. Translocation of the Yersinia effector proteins(YopE, YopH, YopT, YopM, YpkA/YopO, and YopP/J) into the target host cell results in disruption of the actin cytoskeleton to inhibit phagocytosis, downregulation of proinflammatory cytokine/chemokine production, and induction of cellular apoptosis of the target cell. Over the past 25 years, studies on the Yersinia effector proteins have unveiled tremendous knowledge of how the effectors enhance Yersinia virulence. Recently, the long awaited crystal structure of YpkA has been solved providing further insights into the activation of the YpkA kinase domain. Multisite autophosphorylation by YpkA to activate its kinase domain was also shown and postulated to serve as a mechanism to bypass regulation by host phosphatases. In addition, novel Yersinia effector protein targets, such as caspase-1, and signaling pathways including activation of the inflammasome were identified. In this review, we summarize the recent discoveries made on Yersinia effector proteins and their contribution to Yersinia path 展开更多
关键词 TYPE SECRETION YERSINIA EFFECTORS INNATE VIRULENCE
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密其为包装打码标识市场增添静电消除新产品 预览
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《绿色包装》 2016年第3期21-22,共2页
数字字母可变信息打码标识,如商品外包装上的“最佳使用日期”、企业网址等,以及条形码、二维码的非接触式喷印,是包装印刷市场的一个重要部分。但承印材料表面所产生的静电,会导致包装印刷质量的降低,甚至会损坏喷印机,从而造成... 数字字母可变信息打码标识,如商品外包装上的“最佳使用日期”、企业网址等,以及条形码、二维码的非接触式喷印,是包装印刷市场的一个重要部分。但承印材料表面所产生的静电,会导致包装印刷质量的降低,甚至会损坏喷印机,从而造成严重损失。 展开更多
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