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Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments 预览
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作者 Garth L. Nicolson 《临床医学国际期刊(英文)》 2019年第10期477-522,共46页
The presence of pathogenic mycoplasmas in various chronic illnesses and their successful suppression using conventional and integrative medicine approaches are reviewed. Evidence gathered over the last three decades h... The presence of pathogenic mycoplasmas in various chronic illnesses and their successful suppression using conventional and integrative medicine approaches are reviewed. Evidence gathered over the last three decades has demonstrated the presence of pathogenic mycoplasma species in the blood, body fluids and tissues from patients with a variety of chronic clinical conditions: atypical pneumonia, asthma and other respiratory conditions;oral cavity infections;urogenital conditions;neurodegenerative and neurobehavioral diseases;autoimmune diseases;immunosuppressive diseases;inflammatory diseases;and illnesses and syndromes of unknown origin, such as fatiguing illnesses. Only recently have these small intracellular bacteria received attention as possible causative agents, cofactors or opportunistic infections or co-infections in these and other conditions. Their clinical management is often inadequate, primarily because of missed diagnosis, under- and inadequate treatment and the presence of persister or dormant microorganisms due to biofilm, resistence and other mechanisms. Pathogenic Mycoplasma species infections have been suppressed slowly by anti-microbial and integrative treatments, resulting in gradual reductions in morbidity, but not in every patient. Even if mycoplasmas are not a cause or an initial trigger for many chronic illnesses, they appear to play important roles in the inception, progression, morbidity and relapse of chronic illnesses in rather large patient subsets. Ignoring such infections can result in failure to achieve eventual patient recovery, even with application of potentially curative treatments. 展开更多
关键词 Chronic Diseases INFECTIONS ANTIBIOTICS Herbel Therapy Immune Enhancement Membrane Lipid Replacement MYCOPLASMA Natural SUPPLEMENTS INTEGRATIVE Medicine
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Prevalence of Intestinal Parasites in Sickle Cell Disease Patients Attending Jos University Teaching Hospital, Nigeria 预览
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作者 Oghenetejiri Anderson-Otunu James Damen 《生物科学与医学(英文)》 2019年第9期1-8,共8页
Several studies have shown that sickle cell disease (SCD) is made worse by infections;it was necessary to carry out this study to ascertain the occurrence of intestinal parasitic infections to the number of SCD patien... Several studies have shown that sickle cell disease (SCD) is made worse by infections;it was necessary to carry out this study to ascertain the occurrence of intestinal parasitic infections to the number of SCD patients infected compared to Non-SCD patients, the impact of the infections on Pack cell volume (PCV) of the SCD patients in Nigeria populace. A total of 140 stool samples were collected from both SCD patients and Non-SCD patients. 3 ml of venous blood, seventy samples in total were collected from the SCD patients only. The blood and stool samples were collected from September 2005 to November 2005;structured questionnaire was administered to each of the patient that gave consent to be part of the study alongside with questionnaire interview. The stool samples were analysed macroscopically and microscopically using saline, iodine and formal-ether concentration technique. The blood samples were analysed by micro-heamatocrit method. The findings showed that a total of six parasites were identified among the SCD patients and a total of thirteen parasites were identified among Non-SCD patients. Although the prevalence of intestinal parasitic infections was low among the research participates, the identified parasites fell into the 4 major categories of intestinal parasites, an indication that SCD patients can be susceptible to any of the intestinal worms/protozoa. Despite a low prevalence of intestinal parasites among the studied individual at the time of this study, it is however, necessary for regular laboratory investigations for intestinal worm/protozoa since they are still a public health problem. 展开更多
关键词 SICKLE CELL Disease INTESTINAL Parasites PREVALENCE PACK CELL Volume INFECTIONS
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Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
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作者 Ke-Liang Li Ben-Zhen Wang +2 位作者 Zi-Pu Li Yi-Lei Li Jing-Jing Liang 《世界儿科杂志(英文版)》 2019年第3期255-261,共7页
Background Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children.Methods A total of 120 RRTI children were randomly divided into active group,remission group,intervention ... Background Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children.Methods A total of 120 RRTI children were randomly divided into active group,remission group,intervention group and control group,meanwhile 30 healthy children were selected as the healthy group.Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months,while the control group received routine treatment.Stool sample were detected to analyze the bacterial strains.The occurrence of respiratory tract infection (RTI) was compared between different groups during 1 year follow-up.Results Compared with the healthy group,the number of Bifidobacteria and Lactobacilli in the active group,remission group,intervention group and control group was significantly decreased (P < 0.05).The number of Bifidobacteria and Lactobacilli in the intervention group was significantly higher compared to other RRTI groups (P < 0.05).During the follow-up period,the average annual frequency of different acute RTI and use of antibiotics were significantly reduced (P < 0.05),the average duration of cough,fever and use of antibiotics at each episode were also significantly shortened (P < 0.05) in the intervention group compared to the control group.Conclusions Children with RRTI are susceptible to intestinal flora imbalance.Oral probiotics can effectively improve the RRTI intestinal microecological balance in children and reduce the frequency of RTI. 展开更多
关键词 Children INTESTINAL FLORA PROBIOTICS RESPIRATORY TRACT INFECTIONS
A组乙型溶血性链球菌感染90例临床分析 预览
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作者 陈阳 朱紫瑶 +1 位作者 章婉 徐志伟 《中国抗生素杂志》 CAS CSCD 2019年第5期591-594,共4页
目的分析总结A组乙型溶血性链球菌(group A Streptococcus pyogens,GAS)感染患者的临床特点以提高诊疗水平。方法收集温州医科大学附属第二医院自2005-2016年收住的90例证实为GAS感染患者的临床资料并进行统计分析。结果GAS感染在儿童... 目的分析总结A组乙型溶血性链球菌(group A Streptococcus pyogens,GAS)感染患者的临床特点以提高诊疗水平。方法收集温州医科大学附属第二医院自2005-2016年收住的90例证实为GAS感染患者的临床资料并进行统计分析。结果GAS感染在儿童中最常见的疾病表现为扁桃体炎(38.0%),成人中则为局部皮肤软组织感染(72.7%)。实验室指标,C反应蛋白(CRP)、白细胞(WBC)、降钙素原(PCT)、抗链球菌溶血素O(ASO)可有所升高。目前GAS对常用抗菌药物仍较敏感。预后89例治愈后出院,1例死亡病例。结论GAS感染在儿童中以学龄期常见,在成人中以中年期常见。GAS感染患者在合理使用抗菌药物后,预后良好,少有危重症感染发生。 展开更多
关键词 A组乙型溶血性链球菌:感染 临床特点
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糖尿病足复发感染90例临床特点及危险因素分析
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作者 吴旭红 廖立新 +1 位作者 潘实 康春福 《中国基层医药》 CAS 2019年第10期1217-1220,共4页
目的通过分析糖尿病足感染患者的临床资料,探讨糖尿病足复发感染的临床特征及相关危险因素。方法选择2014年1月至2017年12月厦门大学附属第一医院整形美容烧伤科收治的糖尿病足感染患者158例为研究对象,其中90例糖尿病足复发感染者,行... 目的通过分析糖尿病足感染患者的临床资料,探讨糖尿病足复发感染的临床特征及相关危险因素。方法选择2014年1月至2017年12月厦门大学附属第一医院整形美容烧伤科收治的糖尿病足感染患者158例为研究对象,其中90例糖尿病足复发感染者,行常规细菌培养,对比分析复发感染与非复发感染患者临床资料,多因素logistic回归分析糖尿病足复发感染相关危险因素。结果90例糖尿病足复发感染者培养108株病原菌,其中革兰阳性菌(G+)、革兰阴性菌(G-)、其他病原菌分别占54.63%(59株)、39.81%(43株)、5.56%(6株),糖尿病足复发感染与非复发感染患者在病程、年龄、白细胞计数、血红蛋白、纤维蛋白原、白蛋白水平及Wanger分级4~5级比例、双下肢周围血管病变、近期使用抗菌药物、溃疡愈合时间比较,差异均有统计学意义(t=6.003、6.132、3.144、4.322、4.513、11.179、7.164,χ^2=4.269、8.613、25.083、23.298,均P<0.05),多因素分析显示糖尿病足复发感染独立危险因素为双下肢周围血管病变、近期使用抗菌药物、溃疡愈合时间≥65 d(χ^2=5.134,4.807,10.512,均P<0.05)。结论溃疡愈合时间≥65 d、双下肢周围血管病变、近期使用抗菌药物的糖尿病足患者复发感染的风险较高,应密切观察,依据患者自身情况早期采取预防措施。 展开更多
关键词 糖尿病足 复发 危险因素 外周血管疾病 抗感染药 伤口愈合
老年股骨转子间骨折患者围手术期程序性死亡受体-1表达水平在判断术后感染中的作用
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作者 张浩 陈楚鹰 +3 位作者 何久盛 张建政 刘智 孙天胜 《中华创伤骨科杂志》 CAS CSCD 北大核心 2019年第9期752-757,共6页
目的探讨老年股骨转子间骨折患者围手术期程序性死亡受体-1(PD-1)表达与感染的关系及预警价值。方法前瞻性招募2015年8月至2016年8月期间解放军总医院第七医学中心骨科收治的119例老年股骨转子间骨折患者(观察组),男86例,女33例;年龄为(... 目的探讨老年股骨转子间骨折患者围手术期程序性死亡受体-1(PD-1)表达与感染的关系及预警价值。方法前瞻性招募2015年8月至2016年8月期间解放军总医院第七医学中心骨科收治的119例老年股骨转子间骨折患者(观察组),男86例,女33例;年龄为(80.7±8.1)岁。选取20例无外伤及严重内科疾病的轻度膝关节骨关节炎患者为对照组。观察组患者采用闭合复位股骨近端髓内钉固定治疗,监测患者术前、术后1、3、5 d外周血T细胞PD-1的表达变化,并根据随访期间是否发生感染分为感染组和无感染组,比较两组患者术前、术后1、3、5 d PD-1的表达变化,分析PD-1表达与感染的关系,评估其预警价值。结果观察组与对照组、感染组与无感染组患者临床基线情况比较差异均无统计学意义(P>0.05),具有可比性。与对照组患者比较,观察组患者术前、术后1、3、5 d PD-1表达显著增高,差异均有统计学意义(P<0.05)。感染组(24例)患者术后1、3、5 d PD-1表达(33.60%±2.44%、35.68%±4.05%、30.36%±4.42%)显著高于无感染组(95例)患者(29.57%±3.20%、21.45%±2.20%、20.94%±2.30%),差异均有统计学意义(P<0.05)。感染组患者PD-1表达在术后3 d达高峰,术后5 d仍未降至术前水平;而无感染组患者PD-1表达仅在术后1 d呈一过性增高。观察组患者术后3 d与术后1 d PD-1表达的差值预测感染并发症的临界值为3.4%,其预测的敏感性和特异性分别为95.6%、92.6%。结论老年股骨转子间骨折患者髓内钉固定术后PD-1表达显著增高,感染患者PD-1表达较无感染患者增高幅度大,持续时间长;术后3 d与术后1 d PD-1表达的差值预测术后28 d内感染发生的敏感性和特异性均较高。 展开更多
关键词 髋骨折 感染 并发症 程序性死亡受体-1
Preface
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作者 Zhi-Ming Zheng Ke Lan +1 位作者 Eric O. Freed Zheng-Li Shi 《中国病毒学:英文版》 CAS CSCD 2019年第2期117-118,共2页
Viral infections remain a global threat to world health in the twenty-first century. They are caused by both DNA and RNA viruses and can manifest as acute or chronic infections, in some cases causing epidemics or even... Viral infections remain a global threat to world health in the twenty-first century. They are caused by both DNA and RNA viruses and can manifest as acute or chronic infections, in some cases causing epidemics or even global pandemics.Persistent viral infections lead to host immunodeficiency and the development of ~12% of human cancers worldwide. 展开更多
关键词 VIRAL INFECTIONS twenty-first CENTURY CANCERS WORLDWIDE
四种常见原发性免疫缺陷病的临床感染和皮肤表现
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作者 刘晓依 陈琢 +3 位作者 吴静 金莹莹 陈同辛 陈戟 《诊断学理论与实践》 2019年第4期442-447,共6页
目的:分析4种原发性免疫缺陷病(primary immunodeficiency disease, PID)的临床感染情况和皮肤特征,帮助皮肤科医师早期识别并诊断这4种疾病。方法:回顾性分析2003年1月至2016年7月在我院确诊的87例年龄为1个月~15岁的PID患者的临床感... 目的:分析4种原发性免疫缺陷病(primary immunodeficiency disease, PID)的临床感染情况和皮肤特征,帮助皮肤科医师早期识别并诊断这4种疾病。方法:回顾性分析2003年1月至2016年7月在我院确诊的87例年龄为1个月~15岁的PID患者的临床感染情况和皮肤特征性表现,其中36例为慢性肉芽肿病(chronic granulomatous disease, CGD),14例为高IgE综合征(hyper-IgE syndrome, HIES),22例为严重联合免疫缺陷病(severe combined immunodeficiency,SCID),15例为Wiskott-Aldrich综合征(Wiskott-Aldrich syndrome, WAS)。结果:87例经临床和基因诊断确诊为PID的患者中,男性为79例,女性为8例,其临床感染情况主要为呼吸道感染(82.76%)、器官脓肿(52.87%)、胃肠道感染(48.28%)、脓毒血症(25.29%)、EB病毒或巨细胞病毒感染(6.90%)。PID患者的皮肤表现主要为早期反复出现的皮肤感染(51.72%),其中细菌感染发生率为42.53%,真菌感染发生率为32.18%,此外还表现为湿疹样(42.53%)、皮肤紫癜(17.24%)等其他一些特征性表现。CGD以早期反复出现的皮肤细菌感染为主,出生不久即有顽固的湿疹和皮肤感染是HIES的主要皮肤表现,SCID则以皮肤黏膜的机会性感染较常见,WAS以皮肤瘀点瘀斑和湿疹表现为主。结论:感染是PID患者的共同特征,而皮肤感染往往是早期识别免疫缺陷的重要临床表现,应予以重视。 展开更多
关键词 原发性免疫缺陷病 慢性肉芽肿病 高IGE综合征 严重联合免疫缺陷病 WAS综合征 感染 皮肤表现
肝衰竭继发感染的预后分析
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作者 高佳师 许振宇 +4 位作者 李琎 何艳 周华英 王文龙 谌资 《中华传染病杂志》 CAS CSCD 2019年第5期271-274,共4页
目的分析继发感染对肝功能衰竭预后的影响.方法回顾性分析中南大学湘雅二医院感染科2015年1月至2017年12月诊断为肝衰竭的住院患者,根据住院期间是否并发感染分为感染组和非感染组,分别检测其肝衰竭病因、感染部位、感染源等.感染组又... 目的分析继发感染对肝功能衰竭预后的影响.方法回顾性分析中南大学湘雅二医院感染科2015年1月至2017年12月诊断为肝衰竭的住院患者,根据住院期间是否并发感染分为感染组和非感染组,分别检测其肝衰竭病因、感染部位、感染源等.感染组又分为细菌和真菌组,分别检测分析其肝肾功能、国际标准化比值( international normalized ratio, INR)、终末期肝病模型( model for end-stage liver disease, MELD)评分、住院天数、住院费用、病死率等.正态分布的连续变量采用t检验,分类变量采用卡方检验比较.结果共纳入住院肝衰竭患者384例,其中男321例,女63例,年龄(45.5 ± 13.4)岁.整个病程中继发感染者240例(62.5%,感染组),无感染者144例(37.5%,未感染组). 384例患者中乙型肝炎病毒(hepatitis B virus, HBV)感染328例(85.4%),丙型肝炎病毒(hepatitis C virus, HCV)感染8例(2.1%),酒精性肝炎10 例(2.6%);肝衰竭临床类型为慢加急性(亚急性)肝衰竭187 例(48.7%),慢性肝衰竭158 例(41.1%).感染组240 例患者中腹腔感染122 例(50.8%),肺部感染84例(35.0%),尿路感染8例(3.3%),胆道感染13例(5.4%),血液感染11例(4.6%).感染组和未感染组入院30 d后总胆红素、肌酐水平,MELD评分,住院天数、住院费用比较差异均有统计学意义(均P<0.01).感染组240例患者送检各种样本362份进行细菌培养,阳性87份(24.0%),病原菌分别为念珠菌15株、曲霉菌8株、鲍曼不动杆菌13株、葡萄球菌10株、大肠埃希菌11株、肺炎克雷伯菌14株,粪产碱杆菌、人苍白杆菌、嗜麦芽窄食单胞菌、嗜水气单胞菌各4株.感染组240例中诊断为细菌感染者182例,真菌感染者58例,两组患者总胆红素、血肌酐、INR、MELD评分和病死率差异均有统计学意义(均P<0.05).结论肝衰竭继发感染率与患者年龄无关,但肝衰竭患者一旦继发感染,尤其是真菌感染,其预后将显著恶化. 展开更多
关键词 肝功能衰竭 继发感染 细菌 真菌 预后
Non-albicans Candida prosthetic joint infections: A systematic review of treatment 预览
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作者 Christos Koutserimpas Stylianos G Zervakis +4 位作者 Sofia Maraki Kalliopi Alpantaki Argyrios Ioannidis Diamantis P Kofteridis George Samonis 《世界临床病例杂志》 2019年第12期1430-1443,共14页
BACKGROUND Non-albicans Candida prosthetic joint infections (PJIs) are rare. Optimal treatment involves a two-stage revision surgery in combination with an antifungal agent. However, no clear guidelines have been deve... BACKGROUND Non-albicans Candida prosthetic joint infections (PJIs) are rare. Optimal treatment involves a two-stage revision surgery in combination with an antifungal agent. However, no clear guidelines have been developed regarding the agent or treatment duration. Hence, a broad range of antifungal and surgical treatments have been reported so far. AIM To clarify treatment of non-albicans Candida PJIs. METHODS A literature review of all existing non-albicans Candida PJIs cases through April 2018 was conducted. Information was extracted about demographics, comorbidities, responsible species, duration and type of antifungal treatment, type of surgical treatment, time between initial arthroplasty and symptom onset, time between symptom onset and definite diagnosis, outcome of the infection and follow-up. RESULTS A total of 83 cases, with a mean age of 66.3 years, were located. The causative yeast isolated in most cases was C. parapsilosis (45 cases;54.2%), followed by C. glabrata (18 cases;21.7%). The mean Charlson comorbidity index was 4.4 ± 1.5. The mean time from arthropalsty to symptom onset was 27.2 ± 43 mo, while the mean time from symptom onset to culture-confirmed diagnosis was 7.5 ± 12.5 mo. A two stage revision arthroplasty (TSRA), when compared to one stage revision arthroplasty, had a higher success rate (96% vs 73%, P = 0.023). Fluconazole was the preferred antifungal agent (59;71%), followed by amphotericin B (41;49.4%). CONCLUSION The combination of TSRA and administration of prolonged antifungal therapy after initial resection arthroplasty is suggested on the basis of limited data. 展开更多
关键词 Fungal PROSTHETIC JOINT INFECTION Knee ARTHROPLASTY INFECTION Hip ARTHROPLASTY INFECTION ANTIFUNGAL TREATMENT Non-albicans Candida PROSTHETIC JOINT infections
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Nested case-control study on risk factors for opportunistic infections in patients with inflammatory bowel disease 预览
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作者 Shan-Shan Gong Yi-Hong Fan +2 位作者 Qing-Qing Han Bin Lv Yi Xu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第18期2240-2250,共11页
BACKGROUND When opportunistic infections occur, patients with inflammatory bowel disease (IBD) commonly display a significantly increased rate of morbidity and mortality. With increasing use of immunosuppressive agent... BACKGROUND When opportunistic infections occur, patients with inflammatory bowel disease (IBD) commonly display a significantly increased rate of morbidity and mortality. With increasing use of immunosuppressive agents and biological agents, opportunistic infections are becoming a hot topic in the perspective of drug safety in IBD patients. Despite the well-established role of opportunistic infections in the prognosis of IBD patients, there are few epidemiological data investigating the incidence of opportunis-tic infections in IBD patients in China. Besides, the risk factors for opportunistic infection in Chinese IBD patients remain unclear. AIM To predict the incidence of opportunistic infections related to IBD in China, and explore the risk factors for opportunistic infections. METHODS A single-center, prospective study of IBD patients was conducted. The patients were followed for up to 12 mo to calculate the incidence of infections. For each infected IBD patient, two non-infected IBD patients were selected as controls. A conditional logistic regression analysis was used to assess associations between putative risk factors and opportunistic infections, which are represented as odds ratios (OR) and 95% confidence intervals (CIs). RESULTS Seventy (28.11%) out of 249 IBD patients developed opportunistic infections. Clostridium difficile infections and respiratory syncytial virus infections were found in 24 and 16 patients, respectively. In a univariate analysis, factors such as the severity of IBD, use of an immunosuppressant or immunosuppressants, high levels of fecal calprotectin, and C-reactive protein or erythrocyte sedimentation rate were individually related to a significantly increased risk of opportunistic infection. Multivariate analysis indicated that the use of any immunosuppressant yielded an OR of 3.247 (95%CI: 1.128-9.341), whereas the use of any two immunosuppressants yielded an OR of 6.457 (95%CI: 1.726-24.152) for opportunistic infection. Interestingly, when immunosuppressants were used in combin 展开更多
关键词 Nested CASE-CONTROL study OPPORTUNISTIC INFECTIONS INFLAMMATORY BOWEL disease
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Clinical characteristics and T-lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections
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作者 贾春辉 《中国医学文摘:内科学分册(英文版)》 2019年第2期81-82,共2页
Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with ... Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with human immunodeficiency virus (HIV)-1 /AIDS and CMV infections were recruited at Peking UnionMedical College Hospital from Jan 2010 to Aug 2017.Their clinical features and immune function were retrospectivelyanalyzed. Patients with only HIV/AIDS inprevious study were recruited as controls. Results All 48patients were at C3 stage, including 36 men and12 women. Five of them were younger than 30 years old,33 cases within 31 - 50 years old,and 10 cases olderthan 50 years old. 展开更多
关键词 CMV Clinical characteristics T-LYMPHOCYTE SUBSETS 48 ACQUIRED immune deficiency syndrome PATIENTS CYTOMEGALOVIRUS INFECTIONS
Mycobacterium chimaera infections following cardiac surgery in Treviso Hospital, Italy, from 2016 to 2019: Cases report 预览
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作者 Walter O Inojosa Mario Giobbia +9 位作者 Giovanna Muffato Giuseppe Minniti Francesco Baldasso Antonella Carniato Francesca Farina Gabriella Forner Maria C Rossi Stefano Formentini Roberto Rigoli Pier G Scotton 《世界临床病例杂志》 2019年第18期2776-2786,共11页
BACKGROUND An epidemic of Mycobacterium chimaera (M. chimaera) infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contaminati... BACKGROUND An epidemic of Mycobacterium chimaera (M. chimaera) infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contamination of the LivaNova 3T heater-cooler unit, which is used also in Italy. International data are advocated to clarify the spectrum of clinical features of the disease as well as treatment options and outcome. We report a series of M. chimaera infections diagnosed in Treviso Hospital, including the first cases notified in Italy in 2016. CASE SUMMARY Since June 2016, we diagnosed a M. chimaera infection in nine patient who had undergone cardiac valve surgery between February 2011 and November 2016. The time between cardiac surgery and developing symptoms ranged from 6 to 97 mo. Unexplained fever, psychophysical decay, weight loss, and neurological symptoms were common complaints. The median duration of symptoms was 32 wk, and the longest was almost two years. A new cardiac murmur, splenomegaly, choroidoretinitis, anaemia or lymphopenia, abnormal liver function tests and hyponatremia were common findings. All the patients presented a prosthetic valve endocarditis, frequently associated to an ascending aortic pseudoneurysm or spondylodiscitis. M. chimaera was cultured from blood, bioprosthetic tissue, pericardial abscess, vertebral tissue, and bone marrow. Mortality is high in our series, reflecting the poor outcome observed in other reports. Three patients have undergone repeat cardiac surgery. Five patients are being treated with a targeted multidrug antimycobacterial regimen. CONCLUSION Patients who have undergone cardiac surgery in Italy and presenting with signs and symptoms of endocarditis must be tested for M. chimaera. 展开更多
关键词 MYCOBACTERIUM chimaera PROSTHETIC valve ENDOCARDITIS SPONDYLODISCITIS Cardiac surgery INFECTIONS Case REPORT
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Community-acquired pneumonia with Acinetobacter radioresistens bacteremia in an immunocompetent host:A case report
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作者 Yi Hern Tan Lishan Jessica Quah Humaira Shafi 《亚太热带医药杂志:英文版》 SCIE CAS 2019年第6期288-290,共3页
Rationale: Acinetobacter radioresistens is a non-fermentative Gram-negative coccobacillus that is environmentally ubiquitous and is an uncommon cause of pneumonia in an immunocompetent patient with no known chronic me... Rationale: Acinetobacter radioresistens is a non-fermentative Gram-negative coccobacillus that is environmentally ubiquitous and is an uncommon cause of pneumonia in an immunocompetent patient with no known chronic medical illness. Patient concerns: A middle-aged Asian male with a smoking history presented with fever and cough. Physical examination was unremarkable. Chest imaging was consistent with pulmonary parenchymal infection and blood culture grew Acinetobacter radioresistens. Diagnosis: Community acquired pneumonia with Acinetobacter radioresistens bacteremia.Interventions: The patient received a combination of intravenous and oral ampicillinsulbactam over 2 weeks.Outcomes: Repeat blood cultures showed resolution of bacteremia. Completion of antimicrobial treatment saw resolution of respiratory symptoms and radiological pneumonic changes. Lessons: Acinetobacter radioresistens causing community-acquired pneumonia in an immunocompetent host has never been described before. It may be a novel emerging infectious agent in pulmonary infections. Its clinical course in this immunocompetent patient appears to be relatively benign. 展开更多
关键词 Case report ACINETOBACTER baumanii BlaOXA-23 gene Carbapenem-hydrolyzing oxacillinases RARE RESPIRATORY INFECTIONS
Status of intestinal parasitic infections among rural and urban populations, southwestern Iran
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作者 Molouk Beiromv Esmat Panabad Abdollah Rafiei 《亚太热带医药杂志:英文版》 SCIE CAS 2019年第3期130-136,共7页
Objective: To evaluate the prevalence and risk factors of intestinal parasitic infections in the urban and rural areas of Shushtar County,southwest Iran.Methods: A total of 1 008 fecal samples were analyzed by direct ... Objective: To evaluate the prevalence and risk factors of intestinal parasitic infections in the urban and rural areas of Shushtar County,southwest Iran.Methods: A total of 1 008 fecal samples were analyzed by direct smear examination,formalinether concentration,and Ziehl-Neelsen and trichrome staining;furthermore,PCR was used to distinguish Trichostrongylus and hookworm species based on 28 S rRNA gene.Results: Totally,16.0% cases tested positive,either with a pathogenic or a non-pathogenic parasite. Protozoa were detected in 14.0%,helminths in 1.0%,protozoa and helminth coinfections were detected in 0.3%,and co-infections of two protozoa were detected in 0.7% of cases. The most common protozoa and helminths were Giardia duodenalis(7.7%) and Trichostrongylus spp.(0.5%),respectively. Among five microscopy Trichostrongylus positive cases,Trichostrongylus culbriformis was successfully identified in three isolates by sequencing. In the rural areas,the prevalence of parasitic infection was higher(9.8%) than that in the urban areas(6.2%). A significant association was found between educational level,type of drinking water,animals contact,hand-washing,and clinical symptoms. Conclusions: This study indicates that intestinal parasitic infections remain as a public health priority in Shushtar County. It seems that drinking water and environmental sanitation are the main risk factors of parasitic infections in rural areas. 展开更多
关键词 INTESTINAL PARASITIC INFECTIONS Risk factors Iran
Prevalence of respiratory syncytial virus infection among children hospitalized with acute lower respiratory tract infections in Southern India 预览
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作者 Sandesh Kini Bhuvanesh Sukhlal Kalal +2 位作者 Sara Chandy Ranjani Shamsundar Anita Shet 《世界临床儿科杂志》 2019年第2期33-42,共10页
BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections among children. AIM To investigate the proportion of RSV and non-RSV respiratory viral infections among hospitalized chil... BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections among children. AIM To investigate the proportion of RSV and non-RSV respiratory viral infections among hospitalized children ≤ 5 years. METHODS Hospitalized children aged < 5 years, with a diagnosis of acute lower respiratory infections (ALRI), admitted between August 2011-August 2013, were included. Cases were defined as laboratory-confirmed RSV and non-RSV respiratory viruses by direct fluorescence assay from the nasopharyngeal wash. RESULTS Of 383 1-59 mo old children hospitalized with an acute lower respiratory infection, 33.9%(130/383) had evidence of viral infection, and RSV was detected in 24.5%(94/383). Co-infections with RSV and other respiratory viruses (influenza A or B, adenovirus, para influenza 1, 2 or 3) were seen in children 5.5%(21/383). Over 90% of the RSV-positive children were under 2 years of age. RSV was detected throughout the year with peaks seen after the monsoon season. Children hospitalized with RSV infection were more likely to have been exposed to a shorter duration of breastfeeding of less than 3 mo. RSV positive children had a shorter hospital stay, although there were significant complications requiring intensive care. Use of antibiotics was high among those with RSV and non-RSV viral infections. CONCLUSION Our study provides evidence of a high proportion of RSV and other virusassociated ALRI among hospitalized children in India. RSV infection was associated with fewer days of hospital stay compared to other causes of lower respiratory infections. A high level of antibiotic use was seen among all respiratory virus-associated hospitalizations. These results suggest the need for implementing routine diagnostics for respiratory pathogens in order to minimize the use of unnecessary antibiotics and plan prevention strategies among pediatric populations. 展开更多
关键词 RESPIRATORY syncytial virus Acute lower RESPIRATORY INFECTIONS CHILDREN Epidemiology India RESPIRATORY VIRAL INFECTION
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Hepatitis in slaughterhouse workers 预览
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作者 Hassan Tariq Muhammad Umar Kamal +5 位作者 Jasbir Makker Sara Azam Usman Ali Pirzada Vaniza Mehak Kishore Kumar Harish Patel 《世界肝病学杂志:英文版(电子版)》 2019年第1期37-49,共13页
Slaughterhouse workers (SHW) are at increased risk of hepatitis which can occur due to different organisms and should be investigated for viral, bacterial, and parasitic organisms. Slaughter house personnel including ... Slaughterhouse workers (SHW) are at increased risk of hepatitis which can occur due to different organisms and should be investigated for viral, bacterial, and parasitic organisms. Slaughter house personnel including butchers are at a higher risk of infections from cuts and blood-letting, with the possible risk of the transmission of blood-borne pathogens to their colleagues. The objective of this review is to evaluate the common etiologies of hepatitis in SHW which will assist in the assessment of these patients presenting with transaminitis. Types of Microorganisms causing hepatitis with their reservoirs, routes of transmission, laboratory diagnosis, clinical features, treatment options and preventive strategies are included in this review. Proper investigation and awareness is of utmost importance as it causes significant financial constraints derived from workers health cost and from livestock production losses when the disease is confirmed. The work up is essential because infected workers might be a source of infections to other colleagues, family and the consumers. 展开更多
关键词 HEPATITIS SLAUGHTERHOUSE workers LIVER INFECTIONS Transaminitis OCCUPATIONAL safety ABATTOIR
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经静脉途径拔除植入心律起搏装置导线25例临床体会
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作者 杨杰 程自平 +6 位作者 陈刚 赵韧 杜丽 冯俊 李超 史学功 林敏 《临床心血管病杂志》 CAS 北大核心 2019年第3期221-224,共4页
目的:回顾性分析和总结经静脉途径拔除植入心律起搏装置(CIED)导线的方法和体会。方法:25例CIED患者(导线断裂3例、感染22例)的47根导线经静脉途径成功拔除,其中6例导线徒手拔除,15例应用锁定钢丝和扩张鞘拔除,1例运用Evolution机械鞘拔... 目的:回顾性分析和总结经静脉途径拔除植入心律起搏装置(CIED)导线的方法和体会。方法:25例CIED患者(导线断裂3例、感染22例)的47根导线经静脉途径成功拔除,其中6例导线徒手拔除,15例应用锁定钢丝和扩张鞘拔除,1例运用Evolution机械鞘拔除,3例经下腔静脉途径拔除;22例患者于对侧植入新的心律起博装置,2例患者无植入新的起搏装置指证,1例患者因感染性心内膜炎积极治疗无效死亡。结果:所有导线均完全拔除,术中术后均未发生严重并发症。结论:经静脉途径拔除CIED导线是根治心律起博装置导线相关问题的重要措施,科学、有效的运用多种器械和技术在复杂病例的应用中十分重要。 展开更多
关键词 植入心律起博装置 导线拔除 感染
Antimicrobial peptides:new hope in the war against multidrug resistance
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作者 James Mwangi Xue Hao +1 位作者 Ren Lai Zhi-Ye Zhang 《动物学研究》 CAS CSCD 2019年第6期488-505,共18页
The discovery of antibiotics marked a golden age in the revolution of human medicine. However,decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevita... The discovery of antibiotics marked a golden age in the revolution of human medicine. However,decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant(MDR) pathogens, including carbapenem-resistant Pseudomonas aeruginosa, vancomycin-resistant enterococci(VRE), methicillin-resistant Staphylococcus aureus(MRSA), and extendedspectrum β-lactamases(ESBL) bearing Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are amongst the most problematic due to the paucity of treatment options,increased hospital stay, and exorbitant medical costs. Antimicrobial peptides(AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs. 展开更多
关键词 MULTIDRUG resistance NOSOCOMIAL INFECTIONS Antimicrobial peptide Antibiotic alternatives
氨基糖苷类等抗菌药物的个体化治疗应用 预览
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作者 匡欢 钟册俊 吕晓菊 《中国抗生素杂志》 CAS CSCD 2019年第11期1232-1237,共6页
合理使用抗菌药物不仅能有力保护人类珍贵的药物资源,而且可促进感染病患者的规范诊治与健康。患者之间、病原菌之间、感染病之间及抗菌药物之间均存在明显差异,抗菌药物个体化治疗是合理用药的必由之路,关注感染病诊治中的人体、病原... 合理使用抗菌药物不仅能有力保护人类珍贵的药物资源,而且可促进感染病患者的规范诊治与健康。患者之间、病原菌之间、感染病之间及抗菌药物之间均存在明显差异,抗菌药物个体化治疗是合理用药的必由之路,关注感染病诊治中的人体、病原体、疾病与药物是个体化治疗的关键,值得临床高度重视。 展开更多
关键词 宿主 病原菌 感染病 抗菌药物 个体化治疗
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