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两种胰岛素强化治疗方案治疗2型糖尿病疗效观察 认领
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作者 乔艳 《中国继续医学教育》 2020年第8期150-152,共3页
目的比较两种不同胰岛素强化治疗方案治疗社区2型糖尿病的临床效果,为临床探讨2型糖尿病有效治疗方案提供依据。方法选择本院2017年2月—2018年11月收治的117例糖尿病患者,随机分为观察组(59例)和对照组(58例),观察组给予胰岛素泵与西... 目的比较两种不同胰岛素强化治疗方案治疗社区2型糖尿病的临床效果,为临床探讨2型糖尿病有效治疗方案提供依据。方法选择本院2017年2月—2018年11月收治的117例糖尿病患者,随机分为观察组(59例)和对照组(58例),观察组给予胰岛素泵与西格列汀片治疗,对照组给予胰岛素泵治疗。比较两组血糖水平、空腹胰岛素及胰岛素抵抗指数、达标时间、用量、低血糖发生率。结果治疗后,两组空腹血糖、餐后2 h血糖水平、胰岛素抵抗指数差异无统计学意义(P>0.05);观察组达标时间为(5.58±1.63)d,对照组为(7.93±1.92)d,观察组较对照组短(P<0.05);观察组每日胰岛素用量为(31.66±4.22)IU,对照组为(36.83±4.39)IU,观察组低于对照组(P<0.05);观察组低血糖发生率为5.08%、对照组为6.90%(P>0.05)。结论胰岛素泵与格列汀片联合治疗社区2型糖尿病可快速控制血糖,缩短达标时间,降低胰岛素用量,且不增加不良反应,较单用胰岛素治疗优势更明显。 展开更多
关键词 胰岛素 强化治疗 社区2型糖尿病 胰岛素泵 磷酸西格列汀 门冬胰岛素
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Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome 认领
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作者 Chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli 《世界糖尿病杂志:英文版(电子版)》 2020年第2期42-51,共10页
BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS w... BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS women.Research has shown that hyperinsulinemia is correlated with increased bone mass.Given that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a result.Subsequently,increased bone mass could be measured using the wrist circumference method.AIM To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with PCOS.METHODS Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were evaluated.The nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and weight.Calculated measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat analyzer.RESULTS The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16.3 cm was found to be the best predictor of IR 展开更多
关键词 WRIST CIRCUMFERENCE INSULIN RESISTANCE Polycystic ovary syndrome Congolese WOMEN Sub-Saharan African WOMEN MARKER of INSULIN RESISTANCE Homeostasis Model Assessment of INSULIN RESISTANCE Easy-to-detect MARKER
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抑制细胞周期蛋白依赖性激酶8表达对小鼠胰岛β细胞增殖及胰岛素分泌功能的影响观察 认领
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作者 张艳 王晨菲 +1 位作者 王思瑶 罗荔 《山东医药》 CAS 2020年第18期35-39,共5页
目的观察抑制细胞周期蛋白依赖性激酶8(CDK8)表达对MIN6胰岛β细胞胰岛素分泌功能及细胞增殖的影响,并探讨其可能作用机制。方法将培养好的MIN6细胞分为3组,观察组转染siRNA-CDK8慢病毒液(可抑制细胞CDK8表达),空白组不给予任何干预,对... 目的观察抑制细胞周期蛋白依赖性激酶8(CDK8)表达对MIN6胰岛β细胞胰岛素分泌功能及细胞增殖的影响,并探讨其可能作用机制。方法将培养好的MIN6细胞分为3组,观察组转染siRNA-CDK8慢病毒液(可抑制细胞CDK8表达),空白组不给予任何干预,对照组转染siRNA-NC慢病毒液(阴性对照),培养48 h。CCK-8检测各组细胞增殖活性(OD值),流式细胞术观察各组细胞周期分布,ELISA法检测各组细胞上清液胰岛素,荧光定量PCR法检测各组细胞CDK8、胰岛素合成相关转录因子(PDX1、INS2和MAFA)、胰岛素转运相关因子GLUT2 mRNA,Western blotting检测各组细胞CDK8、细胞周期蛋白(Cyclin)、过氧化物酶体增殖剂激活受体γ(PPARγ)、增殖细胞核抗原(PCNA)。结果与对照组及空白组比较,观察组细胞OD值降低,G0/G1、S期细胞比例增加,细胞上清液胰岛素水平降低,CDK8、PDX1、INS、MAFA、GLUT2 mRNA相对表达量降低(P均<0.05)。与对照组及空白组比较,观察组CDK8、Cyclin D1、PCNA、PPARγ蛋白相对表达量降低(P均<0.01)。结论抑制CDK8表达的MIN6细胞,细胞增殖活性显著下降,胰岛素分泌减少,其机制可能与抑制Cyclin D1、PCNA及PPARγ蛋白表达相关。 展开更多
关键词 细胞周期素依赖蛋白激酶8 胰腺Β细胞 胰岛素 糖尿病 胰岛素合成相关转录因子 胰岛素转运相关因子 细胞周期蛋白 过氧化物酶体增殖剂激活受体γ 增殖细胞核抗原
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文章速递胰岛素与胰岛素类似物用于胰岛素泵联合二甲双胍对新诊断2型糖尿病患者治疗的临床疗效及药物经济学对比观察 认领
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作者 李玲 李娜 +3 位作者 彭茜 周广举 刘琳 彭乙华 《中国糖尿病杂志》 CAS CSCD 北大核心 2020年第10期747-751,共5页
目的比较Ins及类似物用于胰岛素泵给药(CSⅡ)联合二甲双胍治疗新诊断T2DM的临床疗效与经济性。方法选取2018年1月至2019年2月于我院内分泌科住院治疗的100例新诊断T2DM患者,随机分为诺和灵组(NL组)和诺和锐组(NR组),每组各50例。两组均... 目的比较Ins及类似物用于胰岛素泵给药(CSⅡ)联合二甲双胍治疗新诊断T2DM的临床疗效与经济性。方法选取2018年1月至2019年2月于我院内分泌科住院治疗的100例新诊断T2DM患者,随机分为诺和灵组(NL组)和诺和锐组(NR组),每组各50例。两组均采用CSⅡ联合二甲双胍治疗,比较临床疗效、低BG发生率及成本效果比(C/E)。结果NR、NL组FBG控制时间分别为(4.13±0.34)和(5.31±0.67)d,2 hBG控制时间分别为(5.06±0.53)和(6.07±0.84)d,差异均有统计学意义(P<0.05)。FBG、2 hBG下降1%的成本中NR组C/E分别为21.76元、23.42元,低于NL组32.73元、35.75元。结论使用Ins及类似物用于CSⅡ联合二甲双胍缓释片治疗新诊断T2DM患者可获得较好的临床疗效,胰岛素类似物疗效更佳,经济学效益更高。 展开更多
关键词 胰岛素 胰岛素类似物 二甲双胍 糖尿病 2型 疗效 药物经济学
Predictive Factors of Successful Treatment of Gestational Diabetes with Metformin Monotherapy 认领
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作者 Amr Mostafa Kamel Aboelfath Mustafa Taha Abdelfattah Sharaf El din 《妇产科期刊(英文)》 2020年第8期1036-1044,共9页
<strong>Objective:</strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">To evaluate the factors affecting the success of metformin in ... <strong>Objective:</strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">To evaluate the factors affecting the success of metformin in management of GDM. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A prospective cohort study was done for 94 patients diagnosed with GDM from April 2019 to March 2020 who needed pharmacological treatments in addition to diet and lifestyle modification. Cases treated with metformin monotherapy were compared with others who needed insulin in addition to metformin for glycemic control. Patient characteristics, glycemic control data and neonatal outcome were evaluated. Univariate and multivariate analysis was done to find the independent factors affecting the success of metformin.</span><b><span style="font-family:Verdana;"> Results: </span></b><span style="font-family:Verdana;">Of 94 patients with GDM who needed pharmacological treatment, 73 (77.6%) used only metformin for </span><span><span style="font-family:Verdana;">treatment of GDM and 21 (22.4%) needed insulin to be added to metformin. Multivariate analysis revealed that BMI was the only significant factor that affects the success of metformin alone in control of GDM (p = 0.03). ROC curve of BMI showed that the cut off value of the highest sensitivity is 32.1 above which metformin monotherapy failed to control GDM. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Metformin can be considered as a safe and effective drug for treatment of GDM. Obesity was found as a predictive factor for failure of metformin monotherapy.</span></span></span> 展开更多
关键词 Gestational Diabetes METFORMIN INSULIN
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Overview of Type 2 Diabetes Drugs on the Market 认领
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作者 Yuxi Hu Yongshou Chen 《生物科学与医学(英文)》 2020年第8期1-14,共14页
Type 2 Diabetes Mellitus (T2DM) is a systemic metabolic disorder with complex pathogenesis. In recent years, a variety of new T2DM drugs have emerged, such as sodium-dependent glucose transporters 2 (SGLT-2) inhibitor... Type 2 Diabetes Mellitus (T2DM) is a systemic metabolic disorder with complex pathogenesis. In recent years, a variety of new T2DM drugs have emerged, such as sodium-dependent glucose transporters 2 (SGLT-2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors. As traditional medicines, insulin also has developed kinds of formulations such as quick-acting or premixed insulin. In addition, new treatment schedules combining multiple drugs are also fully explored. The efficacy, the administration, the mechanism, the safety and the price of these drugs are all different, providing patients with multiple options. This paper reviews the main types of type 2 diabetes drugs on the market and describes the mechanism of action. The representative type 2 diabetes treatment drugs are listed, and the advantages and disadvantages of these representative drugs are preliminarily evaluated. This information is reviewed to help doctors with clinical medication. 展开更多
关键词 Type 2 Diabetes Mellitus INSULIN Sodium-Dependent Glucose Transporters 2 Glucagon-Like Peptide-1
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A New Supplement for the Treatment of Metabolic Syndrome in Postmenopausal Women 认领
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作者 Annamaria Giacobbe Alessandra Bitto +2 位作者 Vincenzo Arcoraci Roberta Granese Rosario D’Anna 《食品与营养科学(英文)》 2020年第1期23-31,共9页
Background: Metabolic Syndrome (MS) is considered a cluster of metabolic abnormalities whose pathogenesis is principally attributable to insulin resistance. Lack of estrogens occurs in postmenopausal women and worseni... Background: Metabolic Syndrome (MS) is considered a cluster of metabolic abnormalities whose pathogenesis is principally attributable to insulin resistance. Lack of estrogens occurs in postmenopausal women and worsening insulin resistance and lipid profile, predispose to MS. The aim of the study was to show whether a new supplement containing cinnamon, corosolic acid and glycyrrhizic acid may counteract MS manifestations. Methods: A total of 60 postmenopausal women were enrolled in a randomized, controlled trial;the active treatment group was taking the new supplement for 3 months and was on a hypocaloric diet, control group was only on diet. At the beginning and after 3 months, metabolic variables were evaluated. Results: After 3 months, a significant difference in the treated group was observed for glucose, HOMA, total cholesterol and HDL-cholesterol;whereas, in the control group, a significant difference was shown only for glucose. After 3 months, a significant difference between groups was highlighted only for HDL-cholesterol. Conclusion: This study has shown the naturally occurring components of this new supplement may improve insulin resistance and lipid profile in a small sample of postmenopausal women. 展开更多
关键词 METABOLIC Syndrome POSTMENOPAUSE Insulin Resistance CINNAMON Corosolic ACID Glycyrrhizic ACID
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Insulin Sensitivity and Insulin Secretion Estimated by Homeostatic Model Assessment (HOMA) in Gestational Diabetes Mellitus 认领
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作者 Samira Mahjabeen A. K. M. Shahidur Rahman +6 位作者 Mahmudul Hossain Marufa Mustari Mohaiminul Abedin Tahseen Mahmood Tanzina Iveen Chowdhury Tahmidul Islam Rana Mokarram Hossain 《生物科学与医学(英文)》 2020年第7期44-54,共11页
<strong>Background: </strong>Progressive insulin resistance (IR) is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). Homeostatic model assessment (HOMA) is commonly used as a... <strong>Background: </strong>Progressive insulin resistance (IR) is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). Homeostatic model assessment (HOMA) is commonly used as a parameter of the severity of insulin resistance. <strong>Aims:</strong> To determine indices of insulin resistance (IR) and <em>β</em>-cell function in gestational diabetes mellitus (GDM). <strong>Methods:</strong> This cross sectional study was conducted from March 2017 to September 2018 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. The study was performed with 41 GDM and equal number of pregnant women with normal glucose tolerance (NGT) diagnosed on basis of WHO criterion-2013 during 24 - 40 weeks of gestation. Serum glucose was measured by glucose oxidase method and fasting serum insulin was measured by chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate insulin indices like-insulin resistance (HOMA-IR), <em>β</em>-cell function (HOMA-B) and insulin sensitivity (HOMA-%S). Data were analyzed and compared by statistical tests. <strong>Results: </strong>A total of eighty-two (82) subjects [41 women with GDM (age: 28.29 ± 3.79 years, BMI: 27.16 ± 4.13 kg/m2) and 41 women with NGT (age: 26.22 ± 5.13 years, BMI: 25.27 ± 3.01 kg/m2)] were included in this study. It was observed that GDM women were significantly older (p = 0.041) and had significantly higher BMI (p = 0.020) than pregnant women with NGT. The GDM group had significantly higher IR as indicated by higher fasting insulin value [GDM vs. NGT;10.19 (7.71 - 13.34) vs. 6.88 (5.88 - 8.47) μIU/ml, median (IQR);p = 0.001] and HOMA-IR [GDM vs. NGT;2.31 (1.73 - 3.15) vs. 1.42 (1.15 - 1.76), median (IQR);p < 0.001], poor <em>β</em>-cell secretory capacity [GDM vs. NGT;HOMA-B: 112.63 (83.52 - 143.93) vs. 128.60 (108.77 - 157.58), median (IQR);p = 0.04] and low insulin sensitivity [GDM vs. NGT;HOMA-%S: 43.29 (31.77 - 57.98) vs. 70.42 (56.86 - 86.59), me 展开更多
关键词 Gestational Diabetes Mellitus (GDM) Homeostatic Model Assessment (HOMA) Insulin Resistance (IR) Normal Glucose Tolerance (NGT)
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胰岛素不同使用方式在小儿糖尿病中的治疗效果 认领
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作者 吕清 《糖尿病新世界》 2020年第9期8-9,12,共3页
目的对胰岛素不同使用方式治疗小儿糖尿病的临床疗效进行分析。方法以77例小儿糖尿病为该次研究对象,收治时间在2018年2月-2019年2月,患儿入组后根据计算机分组法分为两组,A组经胰岛素多次皮下注射进行治疗,B组经胰岛素泵进行治疗,对比... 目的对胰岛素不同使用方式治疗小儿糖尿病的临床疗效进行分析。方法以77例小儿糖尿病为该次研究对象,收治时间在2018年2月-2019年2月,患儿入组后根据计算机分组法分为两组,A组经胰岛素多次皮下注射进行治疗,B组经胰岛素泵进行治疗,对比治疗效果。结果A组与B组患儿空腹血糖变化比较差异无统计学意义(P>0.05);B组患儿血糖达标时间、胰岛素总用量、住院时间、血糖、血钠、血钾、IL-6、IL-12、IL-18、TNF-α水平变化均优于A组患儿,数据差异有统计学意义(P<0.05)。结论胰岛素泵治疗小儿糖尿病的疗效较好,具有推广意义。 展开更多
关键词 胰岛素 皮下注射 胰岛素泵 小儿糖尿病
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芙蓉花总黄酮对2型糖尿病模型小鼠血糖及抗氧化能力的影响 认领
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作者 魏玮 相芳 +1 位作者 许诺 周小苏 《中医学报》 CAS 2020年第6期1262-1265,共4页
目的:观察芙蓉花总黄酮对2型糖尿病模型小鼠血糖及抗氧化能力的影响。方法:低剂量链脲佐菌素(STZ,90 mg·kg^-1)腹腔注射加高脂高糖饲料6周喂养,建立2型糖尿病模型小鼠,随机分为空白对照组,模型组,盐酸二甲双胍组(250 mg·kg^-... 目的:观察芙蓉花总黄酮对2型糖尿病模型小鼠血糖及抗氧化能力的影响。方法:低剂量链脲佐菌素(STZ,90 mg·kg^-1)腹腔注射加高脂高糖饲料6周喂养,建立2型糖尿病模型小鼠,随机分为空白对照组,模型组,盐酸二甲双胍组(250 mg·kg^-1),芙蓉花总黄酮高剂量组、中剂量组、低剂量组(400 mg·kg^-1、200 mg·kg^-1、100 mg·kg^-1)。除空白对照组外,其余各组给予高脂高糖饲料喂养6周,6周后除空白对照组外,各组动物一次性腹腔注射链脲佐菌素90 mg·kg^-1,1周后测定空腹血糖水平。各组成模动物连续灌胃6周,每2周测定动态血糖水平;6周后测定各组小鼠血清中糖化血清蛋白(glycated serum protein,GSP)、胰岛素(insulin,INS)、胰岛素抗体(insulin antibody,ICA)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malonaldehyde,MDA)、总抗氧化能力(total antioxidant capacity,T-AOC)、谷胱甘肽过氧化物酶(glutathion peroxidase,GSH-PX)水平。结果:芙蓉花总黄酮高剂量、中剂量可显著降低成模动物动态血糖水平及血清GSP、ICA、MDA水平,升高血清INS、SOD、T-AOC、GSH-PX水平(P<0.01);芙蓉花总黄酮小剂量可降低模型小鼠动态血糖水平及GSP、ICA、MDA水平,升高血清INS、SOD、GSH-PX水平(P<0.05)。结论:芙蓉花总黄酮可明显改善2型糖尿病模型小鼠血糖水平,增加胰岛素敏感性,提高机体抗氧化能力。 展开更多
关键词 芙蓉花总黄酮 2型糖尿病 糖化血清蛋白 胰岛素 胰岛素抗体 超氧化物歧化酶 丙二醛 总抗氧化能力 谷胱甘肽过氧化物酶 小鼠
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同种异体脐带间充质干细胞移植治疗树鼩代谢综合征 认领
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作者 阮光萍 姚翔 +3 位作者 蔡学敏 李自安 庞荣清 潘兴华 《中国组织工程研究》 CAS 北大核心 2020年第1期51-58,共8页
背景:目前代谢综合征的治疗主要是改善生活和药物为主的综合性治疗,这些治疗要求患者有较强的随访性且不良反应多,尚不能从根本上改善、延缓代谢综合征发展。目的:探讨树鼩脐带间充质干细胞移植治疗树鼩代谢综合征的疗效,为临床应用干... 背景:目前代谢综合征的治疗主要是改善生活和药物为主的综合性治疗,这些治疗要求患者有较强的随访性且不良反应多,尚不能从根本上改善、延缓代谢综合征发展。目的:探讨树鼩脐带间充质干细胞移植治疗树鼩代谢综合征的疗效,为临床应用干细胞移植治疗代谢综合征提供理论基础及参考方法。方法:实验采用贴壁培养法获得树鼩脐带间充质干细胞,鉴定其符合脐带间充质干细胞的生物学特性,深红色荧光碘化物DIR标记树鼩脐带间充质干细胞。32只树鼩给予高糖高胆固醇高盐饲料及糖水饮食,联合注射链脲佐菌素诱导代谢综合征模型,随机分为模型对照组(n=10)和脐带间充质干细胞治疗组(n=22)。治疗组树鼩经尾静脉注射体外标记的脐带间充质干细胞,模型对照组树鼩于同一时间注入等体积的生理盐水。移植后进行血液生化指标、葡萄糖耐量、胰岛素抵抗指数和动脉血压检测。结果与结论:①成功构建树鼩代谢综合征模型,表现出明显的胰岛素抵抗、高血糖、脂代谢紊乱、高血压,符合代谢综合征诊断标准;②脐带间充质干细胞移植能够显著降低代谢综合征树鼩血糖、血脂,改善胰岛素抵抗,调节胰岛素分泌;③移植的脐带间充质干细胞可归巢至代谢综合征树鼩肝脏、肾脏及胰腺组织内,并产生一定的修复作用。 展开更多
关键词 代谢综合征 脐带间充质干细胞 树鼩 细胞移植 血糖 胰岛素 胰岛素抵抗
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沙格列汀联合胰岛素用药在2型糖尿病治疗中的临床作用 认领
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作者 陈维平 谢芸 《中外医学研究》 2020年第15期136-138,共3页
目的:探讨沙格列汀联合胰岛素用药在2型糖尿病治疗中的临床作用。方法:共选取100例2型糖尿病患者为研究对象,选自2018年1月-2019年6月,患者按照随机盲选法平分成两组,分别列入到对照组与观察组中,每组50例,其中一组成员采用胰岛素皮下... 目的:探讨沙格列汀联合胰岛素用药在2型糖尿病治疗中的临床作用。方法:共选取100例2型糖尿病患者为研究对象,选自2018年1月-2019年6月,患者按照随机盲选法平分成两组,分别列入到对照组与观察组中,每组50例,其中一组成员采用胰岛素皮下注射治疗,另外一组成员联合采用沙格列汀治疗,对比两组血糖水平(FBG、2 h PG及HbA1c)及胰岛素抵抗指数(HOMA-β及HOMA-IR)。结果:与对照组比较,观察组FBG、2 h PG及HbA1c水平下降幅度更大,血糖控制效果更佳(P<0.05);观察组HOMA-β指数(40.56±6.18),对照组为(30.85±4.49),观察组显著高于对照组(P<0.05);观察组HOMA-IR指数(2.01±0.2),对照组为(2.55±0.35),观察组显著低于对照组(P<0.05)。结论:针对2型糖尿病患者,沙格列汀联合胰岛素用药降糖效果明显,能有效改善胰岛素抵抗指数,有利于疾病预后。 展开更多
关键词 沙格列汀 胰岛素 2型糖尿病 血糖水平 胰岛素抵抗指数
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Adverse Effects of Sedentary Lifestyles: Inflammation, and High-Glucose Induced Oxidative Stress—A Double Blind Randomized Clinical Trial on Diabetic and Prediabetic Patients 认领
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作者 Xanya Sofra Sheetal Badami 《健康(英文)》 2020年第8期1029-1048,共20页
Sedentary lifestyles promote adipose tissue accumulation that generates systemic inflammation and oxidative damage. Physical activity induces cardiovascular fitness, increases muscle mass, and healthy blood glucose re... Sedentary lifestyles promote adipose tissue accumulation that generates systemic inflammation and oxidative damage. Physical activity induces cardiovascular fitness, increases muscle mass, and healthy blood glucose regulation, while reducing visceral fat, triglycerides and low-density lipoproteins. It is theoretically possible to develop a long-term multi-exercise regimen for health management and enhancement. Pragmatically, time and career restraints, individual choices, genetic factors, or demoralization due to the draconian commitment involved in weight loss, have rendered over a billion of individuals obese, or overweight, burdened by excess lipids, insulin resistance, elevated glucose levels, and inflammation, that foster a number of medical conditions including diabetes. Strenuous overtraining has ensued adverse effects, including an upsurge of proinflammatory cytokines, and hyperglycemia. We implemented an one-month long innovative method with 20 diabetic and prediabetic patients. Results demonstrated a statistically significant reduction of both fasting and PP blood glucose. Fasting and PP insulin reached optimal levels. There was a substantial decline in dyslipidemia, reflecting a reverse relationship of elevated HDL versus triglycerides descending towards the normal range. The notable visceral fat reduction was validated by sonography reports that indicated no evidence of fatty liver in seven patients previously diagnosed with hepatic steatosis. These findings have important implications in improving the health status of obese diabetic and prediabetic individuals, by helping them jumpstart an active lifestyle, or by serving as an exercise alternative to reduce lipids, blood glucose levels and insulin resistance. 展开更多
关键词 INFLAMMATION Oxidative Stress Visceral Adiposity LIPOPROTEINS TRIGLYCERIDES Blood Glucose Insulin Hepatic Steatosis DYSLIPIDEMIA ANALGESIA Diabetes PREDIABETES Weight Loss Exercise
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Influence of Diet Behavior on Insulin Resistance in Hypertensive Black Sub-Saharan Africans: A Multicentric, Cross-Sectional Study 认领
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作者 Kianu Phanzu Bernard Nkodila Natuhoyila Aliocha +4 位作者 Kokusa Zamani Roger Limbole Baliko Emmanuel Kintoki Vita Eleuthère M’buyamba Kabangu Jean-Réné Longo-Mbenza Benjamin 《心血管病(英文)》 2020年第9期615-638,共24页
<div style="text-align:justify;"> <strong>Background</strong>: <span "="">Insulin resistance (IR) is the backbone of cardiovascular diseases (CVDs). The latter are the ... <div style="text-align:justify;"> <strong>Background</strong>: <span "="">Insulin resistance (IR) is the backbone of cardiovascular diseases (CVDs). The latter are the most common non-communicable diseases globally. Diet is an important determinant of CVDs. The link between diet and cardiovascular health could be explained by an association between diet pattern and IR. <b>Aims</b>: To investigate the association between salt and specific food consumption as well as different diet patterns (Mediterranean, westernized, and intermediate dietary patterns) with HOMAIR as a surrogate marker of IR, and fasting insulin in Black, sub-Saharan essential hypertensive</span> patient<span "="">s. <b>Methods</b>: The multicentric, cross-sectional analysis involved 77 Congolese Black hypertensive participants with no history of cardiovascular disease. Daily sodium chloride intake (NaCl g/24h) was estimated from 24-hour urine collection. Dietary behaviours were evaluated through a semi-quantitative food frequency questionnaire (FFQ). Homeostatic model assessment of insulin resistance (HOMAIR) ≥ 2.5 was used as surrogate marker of IR. <b>Results</b>: A decrease in weekly consumption of fruits, vegetables and fish would significantly explain an increase of 29% (r = 0.292;p = 0.010), 24% (r = 0.242;p = 0.034) and 23% (r = 0.226;p = 0.048) of the value of HOMAIR respectively. In contrast, an increase in daily sodium chloride intake was associated with 28% (r = 0.283, p = 0.027) of the increase in HOMAIR. Also, a decrease in the average weekly consumption of fruit, vegetables and fish would significantly explain an increase of 25% (r = 0.247;p = 0.030), 30% (r = 0.302;p = 0.008) and 31% (r = 0.313;p = 0.006) of fasting insulin. In contrast, an increase in red meat consumption was associated with a 26% increase (r = 0.257, p = 0.024) in fasting insulin. In multivariable adjusted analysis 45% of variation in fasting insulin (R<sup>2</sup> = 0.452;overall p = 0.005) were explained by fruits, vegetables and fish consumption. 38% of vari 展开更多
关键词 Diet Behavior Insulin Resistance Hypertension BLACK Sub-Saharan Africans
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评价不同胰岛素给药方式在糖尿病患者治疗中的应用及胰岛素日用剂量的影响 认领
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作者 兰灵 朱晓慧 《糖尿病新世界》 2020年第13期80-82,共3页
目的分析在糖尿病患者治疗中采用不同胰岛素给药方式的效果以及对胰岛素日用剂量的影响。方法将2017年10月—2018年8月在该院接受治疗的92例糖尿病患者纳入研究,均接受胰岛素治疗,根据给药方式差异分为两个组别,对照组(46例)采用皮下注... 目的分析在糖尿病患者治疗中采用不同胰岛素给药方式的效果以及对胰岛素日用剂量的影响。方法将2017年10月—2018年8月在该院接受治疗的92例糖尿病患者纳入研究,均接受胰岛素治疗,根据给药方式差异分为两个组别,对照组(46例)采用皮下注射,实验组(46例)采用胰岛素泵治疗。通过血清生化检验观察两组患者治疗前后空腹血糖和餐后2 h血糖水平;统计两组患者低血糖发生率、血糖达标时间和胰岛素日用剂量。结果实验组治疗后空腹血糖和餐后2 h血糖均低于对照组,差异有统计学意义(P<0.05);对比两组患者低血糖发生率、血糖达标时间和胰岛素日用剂量,实验组明显更低,差异有统计学意义(P<0.05)。结论胰岛素泵给药方式应用于糖尿病患者治疗中,能够在短时间内更好地控制血糖,同时减少低血糖和胰岛素日用剂量,应用价值明显。 展开更多
关键词 胰岛素 糖尿病 胰岛素泵 血糖
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沙格列汀联合胰岛素治疗在2型糖尿病中的应用效果 认领
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作者 何美艳 李远 +1 位作者 邹丹婷 刘俊均 《中国当代医药》 2020年第20期73-75,79,共4页
目的探讨沙格列汀联合胰岛素治疗在2型糖尿病中的应用效果。方法回顾性分析我院2017年1月~2019年1月收治的120例2型糖尿病患者的临床资料,按照用药方式不同分为参照组(n=60)与研究组(n=60)。参照组采用胰岛素治疗,研究组采用胰岛素联合... 目的探讨沙格列汀联合胰岛素治疗在2型糖尿病中的应用效果。方法回顾性分析我院2017年1月~2019年1月收治的120例2型糖尿病患者的临床资料,按照用药方式不同分为参照组(n=60)与研究组(n=60)。参照组采用胰岛素治疗,研究组采用胰岛素联合沙格列汀治疗。比较两组的血糖控制情况、治疗效果、血糖达标时间。结果研究组治疗后的糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PG)水平低于参照组,差异有统计学意义(P<0.05)。研究组的治疗总有效率为96.67%,高于参照组的83.33%,差异有统计学意义(P<0.05)。研究组的胰岛素用量少于参照组,血糖达标时间短于参照组,差异有统计学意义(P<0.05)。研究组治疗后的体重指数低于参照组,日内血糖平均波动幅度(MAGE)、日内血糖波动次数(NGE)、高血糖曲线下面积(AUC)、日间血糖平均绝对差(MODD)低于参照组,差异有统计学意义(P<0.05)。结论采取沙格列汀、胰岛素联合用药治疗2型糖尿病患者,能有效控制其血糖水平,临床效果显著,且可以减少胰岛素用量,缩短血糖达标时间,临床价值显著。 展开更多
关键词 沙格列汀 胰岛素 2型糖尿病 血糖水平 疗效 胰岛素用量
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HbA1c、C肽、胰岛素、IGF-1对巨大儿诊断的临床价值 认领
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作者 肖淑兰 薛海霞 +2 位作者 刘丽莉 闫引弟 汪淑琴 《宁夏医科大学学报》 2020年第8期827-829,共3页
目的探讨产妇糖化血红蛋白(HbA1c)、C肽、胰岛素、胰岛素样生长因子-1(IGF-1)对巨大儿诊断的临床价值。方法回顾性分析2015年9月至2018年2月在银川市第二人民医院分娩的256例产妇的临床资料。根据分娩新生儿体质量,分为巨大儿组(体质量&... 目的探讨产妇糖化血红蛋白(HbA1c)、C肽、胰岛素、胰岛素样生长因子-1(IGF-1)对巨大儿诊断的临床价值。方法回顾性分析2015年9月至2018年2月在银川市第二人民医院分娩的256例产妇的临床资料。根据分娩新生儿体质量,分为巨大儿组(体质量>4000 g,72例)和对照组(体质量<4000 g,112例)。比较两组产妇HbA1c、血清胰岛素、C肽、IGF-1水平。结果巨大儿组产妇HbA1C、C肽、IGF-1、妊娠期体质量平均增长率和巨大儿家族史比例均高于对照组(P均<0.05)。结论孕期母体血清中的HbA1c、C肽、IGF-1对巨大胎儿的诊断有一定帮助。 展开更多
关键词 HBA1C C肽 胰岛素 IGF-1
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西格列汀与二甲双胍分别联合胰岛素对2型糖尿病患者胰岛素功能及糖脂代谢的影响 认领
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作者 霍光强 《临床医学工程》 2020年第9期1193-1194,共2页
目的探讨西格列汀与二甲双胍分别联合胰岛素对2型糖尿病患者胰岛素功能及糖脂代谢的影响。方法将60例2型糖尿病患者随机分为观察组(n=30)和对照组(n=30)。对照组采用二甲双胍联合胰岛素治疗,观察组采用西格列汀联合胰岛素治疗。比较两... 目的探讨西格列汀与二甲双胍分别联合胰岛素对2型糖尿病患者胰岛素功能及糖脂代谢的影响。方法将60例2型糖尿病患者随机分为观察组(n=30)和对照组(n=30)。对照组采用二甲双胍联合胰岛素治疗,观察组采用西格列汀联合胰岛素治疗。比较两组的胰岛素功能指标及糖脂代谢指标。结果治疗后,观察组的FINS、HOMA-IR水平低于对照组,HOMA-β水平高于对照组(P<0.05)。治疗后,观察组的TC、TG、LDL-C、FPG水平低于对照组,HDL-C水平高于对照组(P<0.05)。结论西格列汀联合胰岛素治疗在改善2型糖尿病患者胰岛素功能及糖脂代谢方面效果更佳,值得临床推广。 展开更多
关键词 2型糖尿病 西格列汀 二甲双胍 胰岛素 胰岛素功能 糖脂代谢
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不同胰岛素给药模式对高龄妊娠期糖尿病患者血糖控制及母婴结局的影响 认领
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作者 蔡玲 《医学信息》 2020年第4期141-143,共3页
目的比较胰岛素泵持续皮下注射与多次皮下注射两种胰岛素给药模式对高龄妊娠期糖尿病(GDM)患者血糖控制及母婴结局的影响。方法选取2017年1月~2018年6月襄州区人民医院收治的高龄GDM患者100例作为研究对象,按照随机数字表法分为对照组... 目的比较胰岛素泵持续皮下注射与多次皮下注射两种胰岛素给药模式对高龄妊娠期糖尿病(GDM)患者血糖控制及母婴结局的影响。方法选取2017年1月~2018年6月襄州区人民医院收治的高龄GDM患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。两组均予以胰岛素治疗,对照组采用多次皮下注射的给药模式,观察组采用胰岛素泵持续皮下注射的给药模式,比较两组血糖控制情况[空腹血糖(FPG)、餐后2h血糖(2h PG)、糖化血红蛋白(HbA1c)]、治疗前后血清同型半胱氨酸(Hcy)及胱抑素C(Cys-C)水平变化及母婴结局。结果观察组血糖达标时间短于对照组,胰岛素用量少于对照组,差异有统计学意义(P<0.05)。治疗后,两组FPG、2h PG、HbA1c、Hcy、Cys-C低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组妊娠期高血压、低血糖、早产、羊水过多及新生儿窒息发生率低于对照组,差异有统计学意义(P<0.05);两组死胎、巨大儿、胎儿生长受限、畸形发生率比较,差异无统计学意义(P>0.05)。结论相比于多次皮下注射模式,胰岛素泵持续皮下注射的胰岛素给药模式能够有效提高血糖控制效果,降低血清Hcy、Cys-C水平,改善母婴结局。 展开更多
关键词 胰岛素 多次皮下给药 胰岛素泵 妊娠期糖尿病 血糖 母婴结局
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药物联合治疗糖尿病对患者血清胰岛素、葡萄糖、白细胞计数及淋巴细胞水平的影响 认领
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作者 吴苏豫 赵建林 +2 位作者 熊承云 孙超 毛小芳 《热带医学杂志》 CAS 2020年第3期380-383,共4页
目的探究血清胰岛素、葡萄糖、白细胞计数(WBC)、淋巴细胞水平变化监测在二甲双胍和阿格列汀联合治疗糖尿病疗效的价值。方法选取新乡市中心医院2017年1月12日-2019年1月12日确诊的180例2型糖尿病患者,将其随机分为观察组(n=84)和对照组... 目的探究血清胰岛素、葡萄糖、白细胞计数(WBC)、淋巴细胞水平变化监测在二甲双胍和阿格列汀联合治疗糖尿病疗效的价值。方法选取新乡市中心医院2017年1月12日-2019年1月12日确诊的180例2型糖尿病患者,将其随机分为观察组(n=84)和对照组(n=96)。对照组患者接受二甲双胍治疗,观察组在对照组基础上联合阿格列汀治疗。两组患者均于清晨抽取空腹静脉血,采用葡萄糖氧化酶法测定血糖浓度,放射免疫法测定血胰岛素水平,WBC、淋巴细胞水平使用全自动血细胞分析仪检测。结果治疗后观察组WBC、CD8^+水平低于对照组,CD3^+水平高于对照组,差异均有统计学意义(P<0.05)。治疗后两组WBC、CD8^+、CD3^+水平与治疗前相比差异均有统计学意义(P<0.05)。治疗后观察组空腹血糖、餐后2 h血糖及糖化血红蛋白水平低于对照组,差异均有统计学意义(P<0.05)。治疗前两组胰岛素释放量差异无统计学意义(P>0.05),治疗后,对照组与观察组胰岛素释放量显著升高(P<0.05),HOMA-IR显著降低(P<0.05)。结论二甲双胍联用阿格列汀可有效纠正糖尿病患者的高血糖,降低患者WBC、CD8^+水平,提高CD3^+与CD4^+/CD8^+水平,改善机体免疫功能,减少感染风险。同时也可改善患者的胰岛素敏感性和胰岛素分泌功能。 展开更多
关键词 2型糖尿病 INSULIN GLUCOSE WBC T淋巴细胞亚群
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