In the field of medical imaging,the traditional local binary pattern (LBP)and its improved algorithms are often sensitive to noise.Traditional LBPs are solely based on the signal information from local differences,and...In the field of medical imaging,the traditional local binary pattern (LBP)and its improved algorithms are often sensitive to noise.Traditional LBPs are solely based on the signal information from local differences,and the binary quantization method oversimplifies the local texture features while disregarding the imaging information from the concaveconvex regions between the high-order pixels and the neighboring sampling points.Therefore,we propose an improved Derived Mean Complete Local Binary Pattern (DM_CLBP) algorithm based on high-order derivatives.In the DM_CLBP method,the grey value of a single pixel is replaced by the mean grey value of the rectangular area block,and the difference between pixel values in the area is obtained using the second-order differentiation method.Based on the calculation concept of the complete local binary pattern (CLBP)algorithm,the cascade signs and magnitudes of the two components are encoded and recombined in DM_CLBP using a uniform pattern.The results from the experiments showed that the proposed DM_CLBP descriptors achieved a classification accuracy of 94.4%.Compared with LBP and other improved algorithms,the DM_CLBP algorithm presented in this study can effectively differentiate between lesion areas and normal areas in thyroid MR,(magnetic resonance)images and shows the improved accuracy of area classification.展开更多
The formation and evolution of permafrost in China during the last 20 ka were reconstructed on the basis of large amount of paleo-permafrost remains and paleo-periglacial evidence, as well as paleo-glacial landforms, ...The formation and evolution of permafrost in China during the last 20 ka were reconstructed on the basis of large amount of paleo-permafrost remains and paleo-periglacial evidence, as well as paleo-glacial landforms, paleo-flora and paleofauna records. The results indicate that, during the local Last Glacial Maximum(LLGM) or local Last Permafrost Maximum(LLPMax), the extent of permafrost of China reached 5.3×106-5.4×106 km2, or thrice that of today, but permafrost shrank to only0.80×106-0.85×106 km2, or 50% that of present, during the local Holocene Megathermal Period(LHMP), or the local Last Permafrost Minimum(LLPMin). On the basis of the dating of periglacial remains and their distributive features, the extent of permafrost in China was delineated for the two periods of LLGM(LLPMax) and LHMP(LLPMin), and the evolution of permafrost in China was divided into seven periods as follows:(1) LLGM in Late Pleistocene(ca. 20000 to 13000-10800 a BP)with extensive evidence for the presence of intensive ice-wedge expansion for outlining its LLPMax extent;(2) A period of dramatically changing climate during the early Holocene(10800 to 8500-7000 a BP) when permafrost remained relatively stable but with a general trend of shrinking areal extent;(3) The LHMP in the Mid-Holocene(8500-7000 to 4000-3000 a BP)when permafrost degraded intensively and extensively, and shrank to the LLPMin;(4) Neoglaciation during the late Holocene(4000-3000 to 1000 a BP, when permafrost again expanded;(5) Medieval Warming Period(MWP) in the late Holocene(1000-500 a BP) when permafrost was in a relative decline;(6) Little Ice Age(LIA) in the late Holocene(500-100 a BP), when permafrost relatively expanded, and;(7) Recent warming(during the 20 th century), when permafrost continuously degraded and still is degrading. The paleo-climate, geography and paleopermafrost extents and other features were reconstructed for each of these seven periods.展开更多
Provincial-level regions restart after a fruitful 2018East China’s Jiangsu Province reported on January 14 that its GDP reached more than 9.2 trillion yuan ($1.36 trillion) in2018, becoming the first Chinese mainland...Provincial-level regions restart after a fruitful 2018East China’s Jiangsu Province reported on January 14 that its GDP reached more than 9.2 trillion yuan ($1.36 trillion) in2018, becoming the first Chinese mainland province to officially announce that its economic aggregate has topped the 9-trillion-yuan hal mark. Jiangsu’s economy has surpassed that of Australia, the 13th largest in the world.Governor Wu Zhenglong unveiled the fi gure at the annual session of the Jiangsu Provincial People’s Congress, the provincial legislature.展开更多
With rapid environmental degeneration and socio-economie development,the human settlement environment (HSE)has experienced dramatic changes and attracted attention from different communities.Consequently,the spatial-t...With rapid environmental degeneration and socio-economie development,the human settlement environment (HSE)has experienced dramatic changes and attracted attention from different communities.Consequently,the spatial-temporal evaluation of natural suitability of the human settlement environment (NSHSE)has become essential for understanding the patterns and dynamics of HSE,and for coordinating sustainable development among regional populations,resources,and environments.This study aims to explore the spatialtemporal evolution of NSHSE patterns in 1997,2005,and 2009 in Fengjie County near the Three Gorges Reservoir Area (TGRA).A spatially weighted NSHSE model was established by integrating multi-source data (e.g.,census data,meteorological data,remote sensing images,DEM data,and GIS data)into one framework,where the Ordinary Least Squares (OLS)linear regression model was applied to calculate the weights of indices in the NSHSE model.Results show that the trend of natural suitability has been first downward and then upward, which is evidenced by the disparity of NSHSE existing in the south,north,and central areas of Fengjie County. Results also reveal clustered NSHSE patterns for all 30 townships.Meanwhile,NSHSE has significant influence on population distribution,and 71.49% of the total population is living in moderate and high suitable districts.展开更多
In the current study, 108 flume experiments with non-uniform, cohesionless sediments have been done to investigate the local scour process around four pairs of side-by-side bridge piers under both open channel and ice...In the current study, 108 flume experiments with non-uniform, cohesionless sediments have been done to investigate the local scour process around four pairs of side-by-side bridge piers under both open channel and ice-covered flow conditions. Similar to local scour around bridge piers under open channel conditions and a single bridge pier, it was observed in the experiments that the maximum scour depth always occurred at the upstream face of the pier under ice-covered conditions. Further, the smaller the pier size and the greater the spacing distance between the bridge piers, the weaker the horseshoe vortices around the bridge piers, and, thus, the shallower the scour holes around them. Finally, empirical equations were developed to estimate the maximum scour depth around two side-by-side bridge piers under both open channel and ice-covered flow conditions.展开更多
Using 116 earthquakes over ML3. 8 in the Inner Mongolia region from 2008 to 2015, the local earthquake magnitude ML and surface wave magnitude MS are remeasured. Based on norm linear regression (SR1 and SR2) and norm ...Using 116 earthquakes over ML3. 8 in the Inner Mongolia region from 2008 to 2015, the local earthquake magnitude ML and surface wave magnitude MS are remeasured. Based on norm linear regression (SR1 and SR2) and norm (OR) orthogonal regression method, we established the conversion relationship between ML and MS . The results were tested with Gaussian disturbance. The result shows that the orthogonal regression method (OR) result has the best fitting curve, and the conversion relation is MS = 0. 96 ML - 0. 10. The difference between our result and Guo Lücan's (MS = 1. 13 ML -1. 08) may be caused by regional tectonic characteristics. MS Inner Mongolia value is significantly higher than the MS empirical value, with an average difference of 0. 23, the difference distribution of empirical relation and the rectified relation is in the range of 0. 2-0. 3.展开更多
Cover ratio of cloud is a very important factor which affects the quality of a satellite image, therefore cloud detection from satellite images is a necessary step in assessing the image quality. The study on cloud de...Cover ratio of cloud is a very important factor which affects the quality of a satellite image, therefore cloud detection from satellite images is a necessary step in assessing the image quality. The study on cloud detection from the visual band of a satellite image is developed. Firstly, we consider the differences between the cloud and ground including high grey level, good continuity of grey level, area of cloud region, and the variance of local fractal dimension (VLFD) of the cloud region. A single cloud region detection method is proposed. Secondly, by introducing a reference satellite image and by comparing the variance in the dimensions corresponding to the reference and the tested images, a method that detects multiple cloud regions and determines whether or not the cloud exists in an image is described. By using several Ikonos images, the performance of the proposed method is demonstrated.展开更多
Model selection strategies have been routinely employed to determine a model for data analysis in statistics, and further study and inference then often proceed as though the selected model were the true model that we...Model selection strategies have been routinely employed to determine a model for data analysis in statistics, and further study and inference then often proceed as though the selected model were the true model that were known a priori. Model averaging approaches, on the other hand, try to combine estimators for a set of candidate models. Specifically, instead of deciding which model is the ’right’ one, a model averaging approach suggests to fit a set of candidate models and average over the estimators using data adaptive weights.In this paper we establish a general frequentist model averaging framework that does not set any restrictions on the set of candidate models. It broaden, the scope of the existing methodologies under the frequentist model averaging development. Assuming the data is from an unknown model, we derive the model averaging estimator and study its limiting distributions and related predictions while taking possible modeling biases into account.We propose a set of optimal weights to combine the individual estimators so that the expected mean squared error of the average estimator is minimized. Simulation studies are conducted to compare the performance of the estimator with that of the existing methods. The results show the benefits of the proposed approach over traditional model selection approaches as well as existing model averaging methods.展开更多
Through the implementation of national bowel cancer screening programmes we have seen a three-fold increase in early pT1 colorectal cancers, but how these lesions should be managed is currently unclear. Local excision...Through the implementation of national bowel cancer screening programmes we have seen a three-fold increase in early pT1 colorectal cancers, but how these lesions should be managed is currently unclear. Local excision can be an attractive option, especially for fragile patients with multiple comorbidities, but it is only safe from an oncological point of view in the absence of lymph node metastasis. Patient risk stratification through careful analysis of histopathological features in local excision or polypectomy specimens should be performed according to national guidelines to avoid under-or over-treatment. Currently national guidelines vary in their recommendations as to which factors should be routinely reported and there is no established multivariate risk stratification model to determine which patients should be offered major resectional surgery.Conventional histopathological parameters such as tumour grading or lymphovascular invasion have been shown to be predictive of lymph node metastasis in a number of studies but the inter-and intra-observer variation in reporting is high. Newer parameters including tumour budding and poorly differentiated clusters have been shown to have great potential, but again some improvement in the inter-observer variation is required. With the implementation of digital pathology into clinical practice, quantitative parameters like depth/area of submucosal invasion and proportion of stroma can be routinely assessed. In this review we present the various histopathological risk factors for predicting systemic spread in pT1 colorectal cancer and introduce potential novel quantitative variables and multivariable risk models that could be used to better define the optimal treatment of this increasingly common disease.展开更多
In this paper, a memetic algorithm with competition(MAC) is proposed to solve the capacitated green vehicle routing problem(CGVRP). Firstly, the permutation array called traveling salesman problem(TSP) route is used t...In this paper, a memetic algorithm with competition(MAC) is proposed to solve the capacitated green vehicle routing problem(CGVRP). Firstly, the permutation array called traveling salesman problem(TSP) route is used to encode the solution, and an effective decoding method to construct the CGVRP route is presented accordingly. Secondly, the k-nearest neighbor(k NN) based initialization is presented to take use of the location information of the customers. Thirdly, according to the characteristics of the CGVRP, the search operators in the variable neighborhood search(VNS) framework and the simulated annealing(SA) strategy are executed on the TSP route for all solutions. Moreover, the customer adjustment operator and the alternative fuel station(AFS) adjustment operator on the CGVRP route are executed for the elite solutions after competition. In addition, the crossover operator is employed to share information among different solutions. The effect of parameter setting is investigated using the Taguchi method of design-ofexperiment to suggest suitable values. Via numerical tests, it demonstrates the effectiveness of both the competitive search and the decoding method. Moreover, extensive comparative results show that the proposed algorithm is more effective and efficient than the existing methods in solving the CGVRP.展开更多
An aerial photo taken on September 4 shows villagers waiting in lines to sell tomatoes to local vegetable processing factories in Sandaoqiao 丁own in the Hetao Irrigation Area in north Ghina’s Inner Mongolia Autonomo...An aerial photo taken on September 4 shows villagers waiting in lines to sell tomatoes to local vegetable processing factories in Sandaoqiao 丁own in the Hetao Irrigation Area in north Ghina’s Inner Mongolia Autonomous Region. The International Commission on Irrigation and Drainage added the area to its World Heritage Irrigation Structures list that day.展开更多
In the fields of machine learning and data mining, label learning is a nascent area of research, and within this paradigm, there is much room for improving multi-label manifold learning algorithms for high-dimensional...In the fields of machine learning and data mining, label learning is a nascent area of research, and within this paradigm, there is much room for improving multi-label manifold learning algorithms for high-dimensional data. Thus far, researchers have experimented with mapping relationships from the feature space to the traditional logical label space(using neighbors in the label space, for example, to predict logical label vectors from the feature space’s manifold structure). Here we combine the feature manifold’s and label space’s local topological structures to reconstruct the label manifold. To achieve this, we use a nonlinear manifold learning algorithm to transform the local topological structure from the feature space to the label space. Our algorithm adopts a regularized leastsquares kernel method to realize the reconstruction process, employing an optimization function to find the best solution. Extensive experiments show that our algorithm significantly improves multi-label manifold learning in terms of learning accuracy and time complexity.展开更多
The thalamostriatal pathway is implicated in Parkinson’s disease(PD);however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents...The thalamostriatal pathway is implicated in Parkinson’s disease(PD);however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease.展开更多
基金the National Natural Science Foundation of China under Grant Nos_61728205,61772242,61402204, and 61572239the Natural Science Foundation of Jiangsu Province of China under Grant No.BK20130529+3 种基金the Research Fund for Advanced Talents of Jiangsu University of China under Grant No.14JDG141the Science and Technology Project of Zhenjiang City of China under Grant No.SH20140110the Special Software Development Foundation of Zhenjiang City of China under Grant No.201322the Science and Technology Support Foundation of Zhenjiang City (Industrial)under Grant No.GY2014013.
文摘In the field of medical imaging,the traditional local binary pattern (LBP)and its improved algorithms are often sensitive to noise.Traditional LBPs are solely based on the signal information from local differences,and the binary quantization method oversimplifies the local texture features while disregarding the imaging information from the concaveconvex regions between the high-order pixels and the neighboring sampling points.Therefore,we propose an improved Derived Mean Complete Local Binary Pattern (DM_CLBP) algorithm based on high-order derivatives.In the DM_CLBP method,the grey value of a single pixel is replaced by the mean grey value of the rectangular area block,and the difference between pixel values in the area is obtained using the second-order differentiation method.Based on the calculation concept of the complete local binary pattern (CLBP)algorithm,the cascade signs and magnitudes of the two components are encoded and recombined in DM_CLBP using a uniform pattern.The results from the experiments showed that the proposed DM_CLBP descriptors achieved a classification accuracy of 94.4%.Compared with LBP and other improved algorithms,the DM_CLBP algorithm presented in this study can effectively differentiate between lesion areas and normal areas in thyroid MR,(magnetic resonance)images and shows the improved accuracy of area classification.
基金supported by the National Natural Science Foundation of China and Russian Foundation for Basic Research(FRBR)on“Formation,evolution and changes of Pleistocene cryogenic deposits in Eastern Asia”(Grant No.41811530093)the Key Program of the Department of International Cooperation of the Chinese Academy of Sciences(Assessment of changes in permafrost in China,Russia and Mongolia and their impacts on key engineering infrastructures),(Permafrost extent in China during the Last Glaciation Maximum and Megathermal)of the Strategic Pilot Science and Technology Program of the Chinese Academy of Sciences(Grant No.XDA05120302)the CAS Overseas Professorship of Sergey S.Marchenko,and under the auspices of the International Permafrost Association Working Group on Global Permafrost Extent During the Last Permafrost Maximum(LPM).
文摘The formation and evolution of permafrost in China during the last 20 ka were reconstructed on the basis of large amount of paleo-permafrost remains and paleo-periglacial evidence, as well as paleo-glacial landforms, paleo-flora and paleofauna records. The results indicate that, during the local Last Glacial Maximum(LLGM) or local Last Permafrost Maximum(LLPMax), the extent of permafrost of China reached 5.3×106-5.4×106 km2, or thrice that of today, but permafrost shrank to only0.80×106-0.85×106 km2, or 50% that of present, during the local Holocene Megathermal Period(LHMP), or the local Last Permafrost Minimum(LLPMin). On the basis of the dating of periglacial remains and their distributive features, the extent of permafrost in China was delineated for the two periods of LLGM(LLPMax) and LHMP(LLPMin), and the evolution of permafrost in China was divided into seven periods as follows:(1) LLGM in Late Pleistocene(ca. 20000 to 13000-10800 a BP)with extensive evidence for the presence of intensive ice-wedge expansion for outlining its LLPMax extent;(2) A period of dramatically changing climate during the early Holocene(10800 to 8500-7000 a BP) when permafrost remained relatively stable but with a general trend of shrinking areal extent;(3) The LHMP in the Mid-Holocene(8500-7000 to 4000-3000 a BP)when permafrost degraded intensively and extensively, and shrank to the LLPMin;(4) Neoglaciation during the late Holocene(4000-3000 to 1000 a BP, when permafrost again expanded;(5) Medieval Warming Period(MWP) in the late Holocene(1000-500 a BP) when permafrost was in a relative decline;(6) Little Ice Age(LIA) in the late Holocene(500-100 a BP), when permafrost relatively expanded, and;(7) Recent warming(during the 20 th century), when permafrost continuously degraded and still is degrading. The paleo-climate, geography and paleopermafrost extents and other features were reconstructed for each of these seven periods.
文摘Provincial-level regions restart after a fruitful 2018East China’s Jiangsu Province reported on January 14 that its GDP reached more than 9.2 trillion yuan ($1.36 trillion) in2018, becoming the first Chinese mainland province to officially announce that its economic aggregate has topped the 9-trillion-yuan hal mark. Jiangsu’s economy has surpassed that of Australia, the 13th largest in the world.Governor Wu Zhenglong unveiled the fi gure at the annual session of the Jiangsu Provincial People’s Congress, the provincial legislature.
基金the Research Funding for the Continuous Work of Three Gorges Project sponsored by the Executive Office of Three Gorges Project Construction Committee (No. 0001792015CB50002).
文摘With rapid environmental degeneration and socio-economie development,the human settlement environment (HSE)has experienced dramatic changes and attracted attention from different communities.Consequently,the spatial-temporal evaluation of natural suitability of the human settlement environment (NSHSE)has become essential for understanding the patterns and dynamics of HSE,and for coordinating sustainable development among regional populations,resources,and environments.This study aims to explore the spatialtemporal evolution of NSHSE patterns in 1997,2005,and 2009 in Fengjie County near the Three Gorges Reservoir Area (TGRA).A spatially weighted NSHSE model was established by integrating multi-source data (e.g.,census data,meteorological data,remote sensing images,DEM data,and GIS data)into one framework,where the Ordinary Least Squares (OLS)linear regression model was applied to calculate the weights of indices in the NSHSE model.Results show that the trend of natural suitability has been first downward and then upward, which is evidenced by the disparity of NSHSE existing in the south,north,and central areas of Fengjie County. Results also reveal clustered NSHSE patterns for all 30 townships.Meanwhile,NSHSE has significant influence on population distribution,and 71.49% of the total population is living in moderate and high suitable districts.
文摘In the current study, 108 flume experiments with non-uniform, cohesionless sediments have been done to investigate the local scour process around four pairs of side-by-side bridge piers under both open channel and ice-covered flow conditions. Similar to local scour around bridge piers under open channel conditions and a single bridge pier, it was observed in the experiments that the maximum scour depth always occurred at the upstream face of the pier under ice-covered conditions. Further, the smaller the pier size and the greater the spacing distance between the bridge piers, the weaker the horseshoe vortices around the bridge piers, and, thus, the shallower the scour holes around them. Finally, empirical equations were developed to estimate the maximum scour depth around two side-by-side bridge piers under both open channel and ice-covered flow conditions.
基金Science for the Earthquake Resilience,China Earthquake Administration(XH18012)the Major Science and Technology Projects “Application Demonstration Research of Key Engineering Monitoring System Based on Microseismic Location Technology”,Inner Mongolia Autonomous Region.
文摘Using 116 earthquakes over ML3. 8 in the Inner Mongolia region from 2008 to 2015, the local earthquake magnitude ML and surface wave magnitude MS are remeasured. Based on norm linear regression (SR1 and SR2) and norm (OR) orthogonal regression method, we established the conversion relationship between ML and MS . The results were tested with Gaussian disturbance. The result shows that the orthogonal regression method (OR) result has the best fitting curve, and the conversion relation is MS = 0. 96 ML - 0. 10. The difference between our result and Guo Lücan's (MS = 1. 13 ML -1. 08) may be caused by regional tectonic characteristics. MS Inner Mongolia value is significantly higher than the MS empirical value, with an average difference of 0. 23, the difference distribution of empirical relation and the rectified relation is in the range of 0. 2-0. 3.
基金supported by the National Natural Science Foundation of China(61702385)the Key Projects of National Social Science Foundation of China(11&ZD189).
文摘Cover ratio of cloud is a very important factor which affects the quality of a satellite image, therefore cloud detection from satellite images is a necessary step in assessing the image quality. The study on cloud detection from the visual band of a satellite image is developed. Firstly, we consider the differences between the cloud and ground including high grey level, good continuity of grey level, area of cloud region, and the variance of local fractal dimension (VLFD) of the cloud region. A single cloud region detection method is proposed. Secondly, by introducing a reference satellite image and by comparing the variance in the dimensions corresponding to the reference and the tested images, a method that detects multiple cloud regions and determines whether or not the cloud exists in an image is described. By using several Ikonos images, the performance of the proposed method is demonstrated.
基金National Science Foundation of USA (Grant Nos.DMS1812048,DMS-1737857,DMS-1513483 and DMS-1418042)National Natural Science Foundation of China (Grant No.11529101).
文摘Model selection strategies have been routinely employed to determine a model for data analysis in statistics, and further study and inference then often proceed as though the selected model were the true model that were known a priori. Model averaging approaches, on the other hand, try to combine estimators for a set of candidate models. Specifically, instead of deciding which model is the ’right’ one, a model averaging approach suggests to fit a set of candidate models and average over the estimators using data adaptive weights.In this paper we establish a general frequentist model averaging framework that does not set any restrictions on the set of candidate models. It broaden, the scope of the existing methodologies under the frequentist model averaging development. Assuming the data is from an unknown model, we derive the model averaging estimator and study its limiting distributions and related predictions while taking possible modeling biases into account.We propose a set of optimal weights to combine the individual estimators so that the expected mean squared error of the average estimator is minimized. Simulation studies are conducted to compare the performance of the estimator with that of the existing methods. The results show the benefits of the proposed approach over traditional model selection approaches as well as existing model averaging methods.
基金Yorkshire Cancer Researchthe National Institute for Health Research+1 种基金the Pelican Cancer Foundationthe Pathological Society of Great Britain and Ireland.
文摘Through the implementation of national bowel cancer screening programmes we have seen a three-fold increase in early pT1 colorectal cancers, but how these lesions should be managed is currently unclear. Local excision can be an attractive option, especially for fragile patients with multiple comorbidities, but it is only safe from an oncological point of view in the absence of lymph node metastasis. Patient risk stratification through careful analysis of histopathological features in local excision or polypectomy specimens should be performed according to national guidelines to avoid under-or over-treatment. Currently national guidelines vary in their recommendations as to which factors should be routinely reported and there is no established multivariate risk stratification model to determine which patients should be offered major resectional surgery.Conventional histopathological parameters such as tumour grading or lymphovascular invasion have been shown to be predictive of lymph node metastasis in a number of studies but the inter-and intra-observer variation in reporting is high. Newer parameters including tumour budding and poorly differentiated clusters have been shown to have great potential, but again some improvement in the inter-observer variation is required. With the implementation of digital pathology into clinical practice, quantitative parameters like depth/area of submucosal invasion and proportion of stroma can be routinely assessed. In this review we present the various histopathological risk factors for predicting systemic spread in pT1 colorectal cancer and introduce potential novel quantitative variables and multivariable risk models that could be used to better define the optimal treatment of this increasingly common disease.
基金supported by the National Science Fund for Distinguished Young Scholars of China(61525304)the National Natural Science Foundation of China(61873328).
文摘In this paper, a memetic algorithm with competition(MAC) is proposed to solve the capacitated green vehicle routing problem(CGVRP). Firstly, the permutation array called traveling salesman problem(TSP) route is used to encode the solution, and an effective decoding method to construct the CGVRP route is presented accordingly. Secondly, the k-nearest neighbor(k NN) based initialization is presented to take use of the location information of the customers. Thirdly, according to the characteristics of the CGVRP, the search operators in the variable neighborhood search(VNS) framework and the simulated annealing(SA) strategy are executed on the TSP route for all solutions. Moreover, the customer adjustment operator and the alternative fuel station(AFS) adjustment operator on the CGVRP route are executed for the elite solutions after competition. In addition, the crossover operator is employed to share information among different solutions. The effect of parameter setting is investigated using the Taguchi method of design-ofexperiment to suggest suitable values. Via numerical tests, it demonstrates the effectiveness of both the competitive search and the decoding method. Moreover, extensive comparative results show that the proposed algorithm is more effective and efficient than the existing methods in solving the CGVRP.
文摘An aerial photo taken on September 4 shows villagers waiting in lines to sell tomatoes to local vegetable processing factories in Sandaoqiao 丁own in the Hetao Irrigation Area in north Ghina’s Inner Mongolia Autonomous Region. The International Commission on Irrigation and Drainage added the area to its World Heritage Irrigation Structures list that day.
基金the National Natural Science Foundation of China(Nos.61702270 and 41471371)the Project funded by China Postdoctoral Science Foundation(No.2017M621592).
文摘In the fields of machine learning and data mining, label learning is a nascent area of research, and within this paradigm, there is much room for improving multi-label manifold learning algorithms for high-dimensional data. Thus far, researchers have experimented with mapping relationships from the feature space to the traditional logical label space(using neighbors in the label space, for example, to predict logical label vectors from the feature space’s manifold structure). Here we combine the feature manifold’s and label space’s local topological structures to reconstruct the label manifold. To achieve this, we use a nonlinear manifold learning algorithm to transform the local topological structure from the feature space to the label space. Our algorithm adopts a regularized leastsquares kernel method to realize the reconstruction process, employing an optimization function to find the best solution. Extensive experiments show that our algorithm significantly improves multi-label manifold learning in terms of learning accuracy and time complexity.
基金supported by the Science Technological Project of Shandong Province(2018CXGC1502 and 2016GSF201058)the National Natural Science Foundation of China(31571104 and 81501149).
文摘The thalamostriatal pathway is implicated in Parkinson’s disease(PD);however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease.