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Ischemic Heart Disease in Women 预览
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作者 Nida Waheed Nicholas Kaufman +1 位作者 Jonathon Seawright Ki Park 《心血管创新与应用》 2019年第B01期305-315,共11页
Cardiovascular disease is a leading cause of morbidity and death among women.Our knowledge of ischemic heart disease has grown tremendously over the past few decades as sex differences in prevalence,presentation,and p... Cardiovascular disease is a leading cause of morbidity and death among women.Our knowledge of ischemic heart disease has grown tremendously over the past few decades as sex differences in prevalence,presentation,and pathophysiology are increasingly being recognized.Women with ischemic heart disease have less coronary atherosclerosis than men.Coronary endothelial dysfunction and microvascular disease have been proposed as important mechanisms that contribute to the cause and prognosis of ischemic heart disease in women.This review outlines sex-specifi c issues in ischemic heart disease,including prevalence,prognosis,pathophysiology,traditional and nontraditional risk factors,screening,and diagnostic testing,as well as management strategies. 展开更多
关键词 ANGINA MICROVASCULAR ANGINA CHEST pain ISCHEMIC heart disease CORONARY MICROVASCULAR DYSFUNCTION
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Emerging Techniques for Cardiovascular PET 预览
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作者 Austin A.Robinson,MD Jamieson M.Bourque,MD,MHS 《心血管创新与应用》 2019年第B04期13-24,共12页
Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular conditions.This review will highlight the status of cardiovascular PET,including the present state of the art an... Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular conditions.This review will highlight the status of cardiovascular PET,including the present state of the art and the expanding pool of clinical evidence guiding its use.Additionally,we highlight upcoming developments in the fi eld,including the development of new tracers and applications of PET to novel indications within cardiovascular medicine. 展开更多
关键词 POSITRON emission tomography(PET) absolute blood fl ow metabolic imaging novel tracers CORONARY artery disease(CAD) CORONARY MICROVASCULAR DYSFUNCTION cardiac infection CONGESTIVE heart failure
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血清YKL-40与2型糖尿病视网膜病变、糖尿病肾病的关系 预览
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作者 林丽君 范培云 +7 位作者 姚勇利 罗玮 蒋艳苹 宋康 王淑琼 范晓霞 谢延玲 李亚楠 《中国高原医学与生物学杂志》 CAS 2019年第2期118-121,129共5页
目的探讨血清几丁质酶3样蛋白1(YKL-40)与2型糖尿病视网膜病变(DR)、糖尿病肾病(DKD)的关系。方法根据眼底检查、尿白蛋白/肌酐(ACR)结果分为无并发症的2型糖尿病(DM)组、非增殖期糖尿病视网膜病变(NPDR)组、增殖期糖尿病视网膜病变(PDR... 目的探讨血清几丁质酶3样蛋白1(YKL-40)与2型糖尿病视网膜病变(DR)、糖尿病肾病(DKD)的关系。方法根据眼底检查、尿白蛋白/肌酐(ACR)结果分为无并发症的2型糖尿病(DM)组、非增殖期糖尿病视网膜病变(NPDR)组、增殖期糖尿病视网膜病变(PDR)组和糖尿病肾病(DKD)组。同时,选取同期在同一医院体检的健康者作为对照(CG)组,通过测定YKL-40等指标,分析健康人、无并发症的2型糖尿病患者及病变程度不同的糖尿病微血管病变患者的血清YKL-40情况。结果1.DR患者血清YKL-40水平明显高于无并发症的T2DM患者,且随DR严重程度加重而升高,YKL-40是DR的独立危险因素;2.DKD患者血清YKL-40水平明显高于无并发症的T2DM患者,YKL-40是DKD的独立危险因素。结论血清YKL-40是2型糖尿病视网膜病变、糖尿病肾病的独立危险因素,与病情严重程度相关,且呈正相关关系。 展开更多
关键词 糖尿病 微血管 病变 炎症 YKL-40
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Novel Imaging Approaches for the Diagnosis of Stable Ischemic Heart Disease in Women 预览
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作者 Viviany R.Taqueti,MD,MPH 《心血管创新与应用》 2019年第B02期375-389,共15页
Conventional recommendations for diagnostic testing for the evaluation of stable ischemic heart disease in women have largely paralleled those in men.Although they are designed primarily for the identifi cation of obs... Conventional recommendations for diagnostic testing for the evaluation of stable ischemic heart disease in women have largely paralleled those in men.Although they are designed primarily for the identifi cation of obstructive coronary artery disease(CAD),traditional approaches can lead to overtesting in women without differentiating who is truly at risk.Several unique factors related to the presentation,diagnosis,and underlying pathophysiology of stable ischemic heart disease in women necessitate a more specific approach to the assessment of their risk,complete with separate guidelines when appropriate.This overview highlights how advanced noninvasive imaging tools,including cardiac computed tomography angiography,positron emission tomography,and cardiac magnetic resonance imaging,are enabling very sensitive assessments of anatomic atherosclerotic plaque burden,macrovessel-and microvessel-related ischemia,and myocardial fi brosis,respectively.Moving forward,effective diagnostic testing will need to identify women at high risk of adverse cardiovascular events(not anatomically obstructive CAD per se)without overtesting those at low risk.Judicious application of novel imaging approaches will be critical to broadening the defi nitions of CAD and ischemia to better refl ect the whole spectrum of pathological phenotypes in women,including nonobstructive CAD and coronary microvascular dysfunction,and aid in the development of needed evidence-based strategies for their management. 展开更多
关键词 CORONARY MICROVASCULAR dysfunction nonobstructive CORONARY artery DISEASE stable ischemic HEART DISEASE HEART DISEASE in WOMEN cardiovascular IMAGING positron emission tomography
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微血管多普勒超声联合吲哚菁绿荧光造影在烟雾病搭桥术中的应用 预览
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作者 邱大志 王宇生 +4 位作者 赵青 朱军 王强 谢满意 李中林 《局解手术学杂志》 2019年第4期279-282,共4页
目的探讨微血管多普勒超声(MDU)联合吲哚菁绿(ICG)荧光造影在治疗烟雾病行颞浅动脉-大脑中动脉(STA-MCA)搭桥术中评估血管通畅性的作用。方法选择2017年1月至2018年4月在徐州医科大学附属医院脑血管外科行STA-MCA搭桥术的13例烟雾病患者... 目的探讨微血管多普勒超声(MDU)联合吲哚菁绿(ICG)荧光造影在治疗烟雾病行颞浅动脉-大脑中动脉(STA-MCA)搭桥术中评估血管通畅性的作用。方法选择2017年1月至2018年4月在徐州医科大学附属医院脑血管外科行STA-MCA搭桥术的13例烟雾病患者,术中运用MDU进行吻合前后STA、MCA近心段和远心段的收缩期峰值血流速度(PSV)、舒张期末血流速度(EDV)、阻力指数(RI)、血流方向及血流频谱形态,分析其差别;并进行荧光造影,与术后复查CTA进行对比。结果术中MDU显示吻合后M4近心段血流速度增快(P<0.01),RI无明显变化(P=0.896),血流方向逆转;M4远心段血流速度增快(P<0.01),RI无明显变化(P=0.103);STA血流速度增快、RI降低(均P<0.01),呈“颅内动脉化”血流频谱改变。术中ICG造影图像清晰,血管形态良好,血流通畅。术后复查CTA,桥血管通畅与术中MDU、荧光造影结果一致。结论术中微血管多普勒超声联合吲哚菁绿荧光造影可无创、反复、准确地判断STA-MCA搭桥术中血管通畅性。 展开更多
关键词 烟雾病 颞浅动脉-大脑中动脉搭桥术 微血管 多普勒超声 吲哚菁绿 荧光造影
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通心络对AMI患者再灌注后心肌和微血管的保护性研究 预览
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作者 周立远 《医学信息》 2019年第11期167-168,共2页
目的研究通心络对急性心肌梗死患者再灌注后心肌和微血管的保护性。方法选取2018年1月~2019年1月在我院治疗的成功实施PCI或溶栓治疗的急性心肌梗死患者94例,随机分为对照组和观察组,各47例。对照组采用常规药物治疗,观察组在对照组基... 目的研究通心络对急性心肌梗死患者再灌注后心肌和微血管的保护性。方法选取2018年1月~2019年1月在我院治疗的成功实施PCI或溶栓治疗的急性心肌梗死患者94例,随机分为对照组和观察组,各47例。对照组采用常规药物治疗,观察组在对照组基础上联合通心络治疗,对比两组治疗后1周、2周、1个月室壁异常节段恢复率、左室舒张末容积(LVEDV)、左室射血分数(LVEF)、丙二醛(MDA)、一氧化氮(NO)等指标。结果观察组治疗后1周、2周、1个月异常室壁运动节段恢复率均高于对照组(P<0.05);治疗后两组LVEF、LVEDV均较治疗前有改善,且观察组优于对照组(P<0.05);治疗后两组MDA均较治疗前降低,NO水平均较治疗前升高,且观察组优于对照组(P<0.05)。结论通心络对急性心肌梗死患者再灌注后心肌和微血管具有良好的保护性,可减轻对患者心肌缺损再灌注损伤。 展开更多
关键词 通心络 急性心肌梗死 微血管
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大鼠狭长窄蒂皮瓣术前局部皮下连续注射rhGH对皮瓣成活、VEGF和CD34表达及微血管的影响 预览
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作者 郑武扬 李均 +4 位作者 方丽焕 黄红浪 万晓群 谢强 李卫华 《临床和实验医学杂志》 2019年第2期133-136,共4页
目的分析大鼠狭长窄蒂皮瓣术前局部皮下连续注射重组人生长激素(rhGH)对皮瓣成活、血管内皮生长因子(VEGF)和CD34表达及微血管的影响。方法随机选取30只健康SD大鼠并分成研究组和对照组,各15只,其中研究组大鼠于术前3d行连续背部右侧拟... 目的分析大鼠狭长窄蒂皮瓣术前局部皮下连续注射重组人生长激素(rhGH)对皮瓣成活、血管内皮生长因子(VEGF)和CD34表达及微血管的影响。方法随机选取30只健康SD大鼠并分成研究组和对照组,各15只,其中研究组大鼠于术前3d行连续背部右侧拟皮瓣区局部皮下注射rhGH,对照组仅于手术当天予皮瓣区局部皮下注射rhGH,两组大鼠均于右侧皮瓣区制作一狭长窄蒂皮瓣模型。术后1周,比较两组大鼠的皮瓣成活面积;并通过酶联免疫吸附试验和免疫组织化学法测定两组大鼠的VEGF和CD34表达,同时比较两组大鼠皮瓣微血管密度。结果术后1周,研究组大鼠的皮瓣成活面积百分率显著高于对照组(P<0.05);同一时间点下,研究组大鼠的VEGF、CD34表达水平、皮瓣微血管密度均较对照组更高(P<0.05)。结论大鼠狭长窄蒂皮瓣术前局部皮下连续注射rhGH有利于提高皮瓣成活率,改善VEGF及CD34表达水平,促进微血管生成,降低皮瓣缺氧、缺血的影响。 展开更多
关键词 大鼠 狭长窄蒂皮瓣术 重组人生长激素 血管内皮生长因子 微血管
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Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability
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作者 Cui-ping Fu Sheng-yu Hao +6 位作者 Xiao-bo Xu Jian Zhou Zi-long Liu Huan Lu Li-min Wang Wei-zhong Jin Shan-qun Li 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第5期630-641,共12页
The integrity of the endothelial barrier is a determinant of the prognosis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated whether and how Sirtuin 1 (SIRT1) maintained the v... The integrity of the endothelial barrier is a determinant of the prognosis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated whether and how Sirtuin 1 (SIRT1) maintained the vascular integrity during ALI. An experimental model of ALI was established in mice through intratracheal administration of LPS (10 mg/kg). LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. Intratracheal administration of the selective SIRT1 activator SRT1720 (6.25 mg/kg) significantly attenuated LPS- induced lung injury, lung hyper-permeability and increased TJs expression, whereas intratracheal administration of the selective SIRT1 inhibitor EX527 (6.25 mg/kg) aggravated LPS-induced ALI. Similar protective effects of SIRT1 on pulmonary cellular permeability were observed in primary human pulmonary microvascular endothelial cells treated with LPS (2 mg/mL) in vitro. We further demonstrated that the RhoA/ROCK signaling pathway was activated in SIRT1 regulation of tight junction permeability. The RhoA/ROCK inhibitor Y-27632 (10 μM) increased the expression of TJs and reversed LPS- or EX527-induced hyper-permeability. In conclusion, SIRT1 ameliorates LPS-induced lung injury via decreasing endothelial tight junction permeability, possibly via RhoA/ ROCK signaling pathway. This finding may contribute to the development of new therapeutic approaches for lung injury. 展开更多
关键词 lung injury LPS SIRT1 protein RhoA/ROCK capillary ENDOTHELIAL PERMEABILITY tight junction proteins SRT1720 EX527 Y-27632 human pulmonary MICROVASCULAR ENDOTHELIAL cells
Magnesium lithospermate B protects the endothelium from in?ammation-induced dysfunction through activation of Nrf2 pathway
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作者 Fei Gao Jiao-meng Li +4 位作者 Cong Xi Hui-hui Li Ying-luo Liu Yi-ping Wang Li-jiang Xuan 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第7期867-878,共12页
Magnesium lithospermate B (MLB) is an active component of Salvia miltiorrhiza Radix, a traditional Chinese herb used in treating cardiovascular diseases. In this study, we investigated the protective effects of MLB ag... Magnesium lithospermate B (MLB) is an active component of Salvia miltiorrhiza Radix, a traditional Chinese herb used in treating cardiovascular diseases. In this study, we investigated the protective effects of MLB against in?ammation-induced endothelial dysfunction in vitro and in vivo, and the underlying mechanisms. Endothelial dysfunction was induced in human dermal microvascular endothelial cells (HMEC-1) in vitro by lipopolysaccharide (LPS, 1 μg/mL). We showed that pretreatment with MLB (10–100 μM) dose-dependently inhibited LPS-induced upregulation of in?ammatory cytokines ICAM1, VCAM1, and TNFα, which contributed to reduced leukocytes adhesion and attenuation of endothelial hyperpermeability in HMEC-1 cells. SD rats were injected with LPS (10 mg/kg, ip) to induce endothelial dysfunction in vivo. We showed that pretreatment with MLB (25–100 mg/kg, ip) dose-dependently restored LPS-impaired endothelial-dependent vasodilation in superior mesenteric artery (SMA), attenuated leukocyte adhesion in mesenteric venules and decreased vascular leakage in the lungs. We further elucidated the mechanisms underlying the protective effects of MLB, and revealed that MLB pretreatment inhibited NF-κB activation through inhibition of IκBα degradation and subsequent phosphorylation of NF-κB p65 in vitro and in vivo. In HMEC-1 cells, MLB pretreatment activated the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway. Knockdown of Nrf2 with siRNA abolished the inhibitory effects of MLB on IκBα degradation and ICAM1 up-regulation, which were mimicked by PKC inhibition (Go6983) or PI3K/Akt inhibition (LY294002). In summary, our results demonstrate that MLB inhibits NF-κB activation through PKC- and PI3K/Akt-mediated Nrf2 activation in HMEC-1 cells and protects against LPS-induced endothelial dysfunction in murine model of acute infammation. 展开更多
关键词 magnesium lithospermate B ENDOTHELIUM human DERMAL MICROVASCULAR endothelial cells rat superior MESENTERIC artery rings LIPOPOLYSACCHARIDE inflammation NRF2 PKC PI3K/Akt
miRNA与糖尿病性微血管损伤与修复的研究进展 预览
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作者 王文一 罗迪 +1 位作者 张依然 王珏 《国际医药卫生导报》 2019年第12期1921-1923,共3页
糖尿病是一种常见的代谢性疾病,血糖浓度长期偏高可导致多器官、系统的微血管损伤并引起一系列并发症,其中糖尿病心肌病症状最为严重。研究表明,miRNA参与糖尿病性心脏病变的发生发展,并能引起血管内皮细胞的生成及功能障碍等。本文miRN... 糖尿病是一种常见的代谢性疾病,血糖浓度长期偏高可导致多器官、系统的微血管损伤并引起一系列并发症,其中糖尿病心肌病症状最为严重。研究表明,miRNA参与糖尿病性心脏病变的发生发展,并能引起血管内皮细胞的生成及功能障碍等。本文miRNA及在糖尿病心肌病的微血管病变及新生机制中的作用作一综述。 展开更多
关键词 MIRNA 糖尿病心肌病 微血管
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微血管周细胞与糖尿病视网膜病变中西医研究进展 预览
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作者 赵永旺 刘峥嵘 秦裕辉 《湖南中医药大学学报》 CAS 2019年第2期277-283,共7页
大量的实验研究已经证实,微血管周细胞在糖尿病视网膜病变早期防治中扮演重要角色。为了观察和研究糖尿病视网膜病变早期微血管周细胞结构和功能变化,本文对近些年微血管周细胞的起源、形态分布、生理功能、细胞培养与鉴定、周细胞凋亡... 大量的实验研究已经证实,微血管周细胞在糖尿病视网膜病变早期防治中扮演重要角色。为了观察和研究糖尿病视网膜病变早期微血管周细胞结构和功能变化,本文对近些年微血管周细胞的起源、形态分布、生理功能、细胞培养与鉴定、周细胞凋亡与糖尿病视网膜病变关系以及中医药防治糖尿病视网膜病变的研究进展进行综述,以期为糖尿病视网膜病变的周细胞研究及早期防治提供一种新思路。 展开更多
关键词 微血管 周细胞 糖尿病视网膜病变 中药 早期防治
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松弛素对冠状动脉微循环的影响 预览
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作者 张楠 王萍 《心血管病学进展》 CAS 2019年第5期704-708,共5页
近年来发现,松弛素不仅可治疗心力衰竭、心肌纤维化、扩张大动脉血管,而且还可扩张微血管,增加微循环血流灌注,抑制炎症活化,保护血管内皮,抑制内皮-间质转化,减轻缺血再灌注损伤,松弛素可以从多方面改善微循环障碍。现就近年来松弛素... 近年来发现,松弛素不仅可治疗心力衰竭、心肌纤维化、扩张大动脉血管,而且还可扩张微血管,增加微循环血流灌注,抑制炎症活化,保护血管内皮,抑制内皮-间质转化,减轻缺血再灌注损伤,松弛素可以从多方面改善微循环障碍。现就近年来松弛素在血管、微血管领域的研究进展进行概述,以期为临床治疗冠状动脉微血管疾病提供新的治疗思路,改善冠状动脉微循环障碍患者的生活质量和减少因心绞痛反复就医带来的巨大医疗消费。 展开更多
关键词 松弛素 微血管 冠状动脉微循环
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Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion 预览
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作者 Zuo-Yan Sun Fu-Jiang Wang +6 位作者 Hong Guo Lu Chen Li-Juan Chai Rui-Lin Li Li-Min Hu Hong Wang Shao-Xia Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期783-793,共11页
Shuxuetong injection composed of leech(Hirudo nipponica Whitman)and earthworm(Pheretima aspergillum)has been used for the clinical treatment of acute stroke for many years in China.However,the precise neuroprotective ... Shuxuetong injection composed of leech(Hirudo nipponica Whitman)and earthworm(Pheretima aspergillum)has been used for the clinical treatment of acute stroke for many years in China.However,the precise neuroprotective mechanism of Shuxuetong injection remains poorly understood.Here,cerebral microvascular endothelial cells(bEnd.3)were incubated in glucose-free Dulbecco’s modified Eagle’s medium containing 95%N2/5%CO2 for 6 hours,followed by high-glucose medium containing 95%O2 and 5%CO2 for 18 hours to establish an oxygen-glucose deprivation/reperfusion model.This in vitro cell model was administered Shuxuetong injection at 1/32,1/64,and 1/128 concentrations(diluted 32-,64-,and 128-times).Cell Counting Kit-8 assay was used to evaluate cell viability.A fluorescence method was used to measure lactate dehydrogenase,and a fluorescence microplate reader used to detect intracellular reactive oxygen species.A fluorescent probe was also used to measure mitochondrial superoxide production.A cell resistance meter was used to measure transepithelial resistance and examine integrity of monolayer cells.The fluorescein isothiocyanate-dextran test was performed to examine blood-brain barrier permeability.Real-time reverse transcription polymerase chain reaction was performed to analyze mRNA expression levels of tumor necrosis factor alpha,interleukin-1β,interleukin-6,and inducible nitric oxide synthase.Western blot assay was performed to analyze expression of caspase-3,intercellular adhesion molecule 1,vascular cell adhesion molecule 1,occludin,vascular endothelial growth factor,cleaved caspase-3,B-cell lymphoma 2,phosphorylated extracellular signal-regulated protein kinase,extracellular signal-regulated protein kinase,nuclear factor-κB p65,I kappa B alpha,phosphorylated I kappa B alpha,I kappa B kinase,phosphorylated I kappa B kinase,claudin-5,and zonula occludens-1.Our results show that Shuxuetong injection increases bEnd.3 cell viability and B-cell lymphoma 2 expression,reduces cleaved caspase-3 expression,inhibits produ 展开更多
关键词 nerve REGENERATION SHUXUETONG injection brain MICROVASCULAR endothelial cells oxygen-glucose deprivation/reperfusion tight junction proteins mitochondrial function inflammatory factors blood-brain barrier neuroprotection neural REGENERATION
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Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension
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作者 Jun-Hong Ren Na Ma +9 位作者 Si-Yu Wang You-Jing Sun Yue-Wei Zhang Fa-Jin Guo Yong-Jun Li Tian-Hui Li Hu Ai Wen-Duo Zhang Peng Li Wei-Hua Ma 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期63-68,共6页
Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP.Thus... Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP.Thus,this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Methods:This will be a single-center diagnostic study with a sample size of 440.Patients with chronic kidney disease (CKD) and suspected of having resistant hypertension will be eligible.Patients with Stages 1–3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA).Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be compared.Moreover,all patients will also undergo radionuclide imaging.The diagnostic value for RAS will be assessed by the receiver operating characteristic curve,including the accuracy,sensitivity,specificity,positive predictive values,negative predictive values,and area under the ROC.Pearson correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. Conclusion:The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension. 展开更多
关键词 RENOVASCULAR hypertension CONTRAST-ENHANCED ultrasound RENAL artery stenosis RENAL MICROVASCULAR perfusion
The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy 预览
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作者 AN Nina YU Luyan +4 位作者 HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun 《中国海洋大学学报:英文版》 SCIE CAS CSCD 2019年第1期253-259,共7页
Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP)has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM).In this study,we aimed to investig... Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP)has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM).In this study,we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model.Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group.Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1),low molecular weight heparin(LMWH),PSS and PSS-NP.Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries.Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats.ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP.Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A,and the phosphorylation of protein kinase B(Akt)and endothelial nitric oxide synthase(eNOS),which were involved in the amelioration of cardiac microvascular endothelial dysfunction.These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM. 展开更多
关键词 PSS-loaded NANOPARTICLES marine drug DCM MICROVASCULAR endothelial DYSFUNCTION
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Do we need to screen every patient in intensive care unit for diabetes in community with high prevalence of diabetes? 预览
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作者 Taru Dutt Rahul Kashyap Salim Surani 《世界糖尿病杂志:英文版(电子版)》 2019年第3期137-139,共3页
Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of e... Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of easily accessibility knowledge about its early signs and symptoms and rapid diagnostic modalities. Critically ill patients with undiagnosed DM are likely to have an increased mortality as compared to intensive care unit (ICU) patients with diagnosed DM. DM may have adverse effect on ICU patients causing organ failure and complications. Early Screening of patients at the risk of developing disease may prevent long term complications. Early screening and management may be beneficial as controlled DM patients have similar morbidity as non DM patients in ICU. An intense glycaemic and blood pressure control improves retinopathy and albuminuria, but may not affect the macrovascular outcomes. 展开更多
关键词 DIABETES MELLITUS INTENSIVE care unit MICROVASCULAR MACROVASCULAR DIABETES screening
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Advances in diabetic microvascular complications and related molecular mechanisms
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作者 Gang Zeng Qun-Fang Ding 《海南医科大学学报(英文版)》 2019年第1期83-86,共4页
With the change of production and life style, the change of dietary structure and the aggravation of population aging, the incidence and fatality rate of diabetes mellitus have been increasing year by year. The pathog... With the change of production and life style, the change of dietary structure and the aggravation of population aging, the incidence and fatality rate of diabetes mellitus have been increasing year by year. The pathogenesis of diabetes varies and is closely related to many factors, such as genetic factors, environmental factors, eating habits and so on. Those that endanger the life quality and survival of diabetic patients are mostly complications, including various macrovascular complications and microvascular complications, such as diabetic cardiomyopathy, diabetic nephropathy, diabetic encephalopathy and diabetic foot. The related molecular mechanisms of the pathogenesis of diabetic nephropathy, diabetic retinopathy and diabetic foot are discussed in this paper to provide reference for new drug research and clinical treatment. 展开更多
关键词 Diabetes COMPLICATIONS MICROVASCULAR COMPLICATIONS DIABETIC NEPHROPATHY DIABETIC FOOT DIABETIC RETINOPATHY
Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression 预览
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作者 Jian Liu Yu-Hong Wang +4 位作者 Wei Li Lin Liu Hui Yang Pan Meng Yuan-Shan Han 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第2期289-297,共9页
Previous studies have shown that models of depression exhibit structural and functional changes to the neurovascular unit. Thus, we hypothesized that diabetes-related depression might be associated with damage to the ... Previous studies have shown that models of depression exhibit structural and functional changes to the neurovascular unit. Thus, we hypothesized that diabetes-related depression might be associated with damage to the hippocampal neurovascular unit. To test this hypothesis, neurons, astrocytes and endothelial cells were isolated from the brain tissues of rat embryos and newborn rats. Hippocampal neurovascular unit co-cultures were produced using the Transwell chamber co-culture system. A model of diabetes-related depression was generated by adding 150 mM glucose and 200 μM corticosterone to the culture system and compared with the neuron + astrocyte and astrocyte + endothelial cell co-culture systems. Western blot assay was used to measure levels of structural proteins in the hippocampal neurovascular unit co-culture system. Levels of basic fibroblast growth factor, angiogenic factor 1, glial cell line-derived neurotrophic factor, transforming growth factor β1, leukemia inhibitory factor and 5-hydroxytryptamine in the hippocampal neurovascular unit co-culture system were measured by enzyme-linked immunosorbent assay. Flow cytometry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling staining was used to assess neuronal apoptosis in the hippocampal neurovascular unit. The neurovascular unit triple cell co-culture system had better barrier function and higher levels of structural and secretory proteins than the double cell co-culture systems. In comparison, in the model of diabetes-related depression, the neurovascular unit was damaged with decreased barrier function, poor structural integrity and impaired secretory function. Moreover, neuronal apoptosis was markedly increased, and 5-hydroxytryptamine levels were reduced. These results suggest that diabetes-related depression is associated with structural and functional damage to the neurovascular unit. Our findings provide a foundation for further studies on the pathogenesis of diabetes-related depression. 展开更多
关键词 nerve REGENERATION hippocampus neurovascular unit neurons astrocytes brain microvascular cells cell culture co-culture diabetes-related DEPRESSION hyperglycemia corticosterone neural REGENERATION
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Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study 预览
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作者 Osman OguzAhsen Kaicheng Liang +3 位作者 Hsiang-Chieh Lee Zhao Wang James G Fujimoto Hiroshi Mashimo 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第16期1997-2009,共13页
BACKGROUND Chronic radiation proctopathy (CRP) occurs as a result of pelvic radiation therapy and is associated with formation of abnormal vasculature that may lead to persistent rectal bleeding. While incidence is de... BACKGROUND Chronic radiation proctopathy (CRP) occurs as a result of pelvic radiation therapy and is associated with formation of abnormal vasculature that may lead to persistent rectal bleeding. While incidence is declining due to refinement of radiation delivery techniques, CRP remains one of the major complications of pelvic radiation therapy and significantly affects patient quality of life. Radiofrequency ablation (RFA) is an emerging treatment modality for eradicating abnormal vasculature associated with CRP. However, questions remain regarding CRP pathophysiology and optimal disease management. AIM To study feasibility of optical coherence tomography angiography (OCTA) for investigating subsurface vascular alterations in CRP and response to RFA treatment. METHODS Two patients with normal rectum and 8 patients referred for, or undergoing endoscopic RFA treatment for CRP were imaged with a prototype ultrahighspeed optical coherence tomography (OCT) system over 15 OCT/colonoscopy visits (2 normal patients, 5 RFA-na?ve patients, 8 RFA-follow-up visits). OCT and OCTA was performed by placing the OCT catheter onto the dentate line and rectum without endoscopic guidance. OCTA enabled depth-resolved microvasculature imaging using motion contrast from flowing blood, without requiring injected dyes. OCTA features of normal and abnormal microvasculature were assessed in the mucosa and submucosa. Blinded reading of OCTA images was performed to assess the association of abnormal rectal microvasculature with CRP and RFA treatment, and rectal telangiectasia density endoscopic scoring. RESULTS OCTA/OCT images are intrinsically co-registered and enabled depth-resolved visualization of microvasculature in the mucosa and submucosa. OCTA visualized normal vascular patterns with regular honeycomb patterns vs abnormal vasculature with distorted honeycomb patterns and ectatic/tortuous microvasculature in the rectal mucosa. Normal arterioles and venules < 200 μm in diameter versus abnormal heterogenous enlarged arterioles and ve 展开更多
关键词 OPTICAL COHERENCE TOMOGRAPHY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY Radiofrequency ablation CHRONIC RADIATION proctopathy Rectal telangiectasia density scoring system Subsurface microvascular imaging
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冠状动脉微血管疾病及其药物治疗研究进展 预览
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作者 朱坤鹏(综述) 陈建英(审校) 《海南医学》 CAS 2018年第23期3369-3372,共4页
近年来,随着冠状动脉造影技术的广泛开展,越来越多胸痛的患者行冠状动脉造影却未发现明显的血管狭窄,现有的研究认为,这些患者可能存在冠状动脉微血管疾病(CMVD),目前其机制尚不十分明确,治疗上也尚无规范化的方法,本文现将CMVD及其药... 近年来,随着冠状动脉造影技术的广泛开展,越来越多胸痛的患者行冠状动脉造影却未发现明显的血管狭窄,现有的研究认为,这些患者可能存在冠状动脉微血管疾病(CMVD),目前其机制尚不十分明确,治疗上也尚无规范化的方法,本文现将CMVD及其药物治疗做一综述,希望为临床诊治CMVD提供一定的参考。 展开更多
关键词 冠状动脉 微血管 冠状动脉微血管疾病 药物治疗 进展
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