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FMS样酪氨酸激酶3在恶性肿瘤中的研究进展
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作者 丁园艺 李艳 张蕊 《中国医药》 2019年第8期1277-1280,共4页
FMS样酪氨酸激酶3(FLT3)改变在血液系统及非血液系统恶性肿瘤中均有发现。血液系统疾病研究多集中于伴FLT3突变的急性髓系白血病,FLT3突变通过激活信号传导和转录激活因子5、蛋白激酶B等通路,促进白血病的发生发展。在实体肿瘤中也有研... FMS样酪氨酸激酶3(FLT3)改变在血液系统及非血液系统恶性肿瘤中均有发现。血液系统疾病研究多集中于伴FLT3突变的急性髓系白血病,FLT3突变通过激活信号传导和转录激活因子5、蛋白激酶B等通路,促进白血病的发生发展。在实体肿瘤中也有研究发现FLT3存在一定作用,如FLT3表达在肝癌发生及侵袭过程起关键作用。因此,FLT3可以成为肿瘤有前景的治疗靶点。 展开更多
关键词 恶性肿瘤 FMS样酪氨酸激酶3 血液系统肿瘤
Hepatitis B Reactivation in Patients with Hematological and Solid Malignancies: A Retrospective Analysis of Single Center’s Experience 预览
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作者 Mustafa Yakut Zeynelabidin Demir +1 位作者 Ahmet Siyar Ekinci Fatime Yakut 《临床医学国际期刊(英文)》 2019年第11期622-629,共8页
Background: Hepatitis B reactivation might occur in patients with hematological and solid organ malignancies due to immunosuppressive effect of chemotherapy. Methods: Fourteen patients were evaluated retrospectively f... Background: Hepatitis B reactivation might occur in patients with hematological and solid organ malignancies due to immunosuppressive effect of chemotherapy. Methods: Fourteen patients were evaluated retrospectively from their files to discuss the clinical manifestations, management, and avoiding of Hepatitis B reactivation within patients who receive immunosuppressive treatment. Results: These 14 HbsAg positive patients were being followed up and treated via oncological immunosuppressive chemotherapy. The ages of the patients were between 25 and 72. Seven of the patients were male, and the average follow up period for the patients was between 10 and 74 months. TV 0, 5 mg was started for seven of the patients before the chemotherapy and TFV 245 mg to one of the patients. LAM 100 was started for three patients whose basal HBV DNA was low. It has been analyzed that HBV DNA was negative in further observations. In follow up controls, we noticed HBV reactivation at two patients, LAM was given one of them and TFV was given the other one. One patient was applied allogeneic transplantation whose basal liver tests were normal and Hbsag was negative. Hepatitis B reactivation was detected after the first week of therapy. Conclusions: We offer testing in all patients undergoing cancer therapy for hepatitis B, HBsAg, core antibody (anti-HBc total), and anti-HBs before to start cancer therapy. Patients with higher risk of HBV reactivation require antiviral prophylaxis. 展开更多
关键词 HEPATITIS B MALIGNANCIES IMMUNOSUPPRESSION
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Profile of Gynaecological Malignancies in Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Southeastern Nigeria 预览
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作者 Ayodele A. Olaleye Johnbosco I. Nwafor +5 位作者 Alfred N. Adiele Chuka N. Obi Sunday U. Asogwa Chukwunenye C. Ibo Darlington-Peter C. Ugoji Ikenna C. Ebere 《临床医学国际期刊(英文)》 2019年第9期428-438,共11页
Background: Comprehensive estimates of the incidence of gynaecological malignancies reported from Nigeria are very limited due to limitation in record maintenance. Female cancer is a public health problem the world ov... Background: Comprehensive estimates of the incidence of gynaecological malignancies reported from Nigeria are very limited due to limitation in record maintenance. Female cancer is a public health problem the world over. The malignancies of the female genital organs are major causes of morbidity and mortality which necessitates data for policy formulation and health planning. Aim: To establish the profile of gynaecologic malignancies reported in our centre, with reference to incidence, histological subtypes and frequency of involvement at various sites and to compare the procured data with those from other national and international centers. Materials and Method: In this descriptive retrospective study, the records pertaining to all the pathological specimens categorized as gynaecological malignancies from January 1st, 2013 to December 31st, 2015 at our facility were studied and compared with the available international data. Data analysis was done using Epi Info software version 7.2.1 (CDC Atlanta Georgia). Result: Two hundred and eleven (211) cases of gynaecological malignancies were seen during the study period and this constituted 13.4% of gynaecological admissions. Cervical malignancies were the commonest constituting 49.2% of all gynaecological malignancies followed by ovarian malignancies (27.8%), endometrial cancers (11.9%), vulva (5.6%), choriocarcina (3.9%) and vagina (1.6%). The data obtained was compared with data from Surveillance, Epidemiology and End Result (SEER) programme in the United States and European Union. All malignancies except cervical cancers affected a younger age group at our centre. Cervical cancers presented at a relatively more advanced stage, Ovarian cancers were more localized, whereas uterine, vulva and vaginal cancers presented at a similar stages as compared to Western data. Conclusion: This study presents a composite data of Gynaecological malignancies from Southeast Nigeria. Advanced stage of presentation of cervical cancers suggests lacunae in screening programmes available 展开更多
关键词 PROFILE GYNAECOLOGICAL MALIGNANCIES Abakaliki NIGERIA
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A Case Report of Double Malignancy—Recurrent Nasopharyngeal Carcinoma and Adenocarcinoma of the Uterus 预览
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作者 Ihab E Ali Farid Razali +2 位作者 Sobani Din Tang Phing Phing K. Y. Loh 《耳鼻喉(英文)》 2019年第6期198-203,共6页
Multiple primary malignancies (MPMs) is a rare clinical condition where a patient is diagnosed with two or more cancers around the same time. Published literature reported the incidence of multiple primaries is in the... Multiple primary malignancies (MPMs) is a rare clinical condition where a patient is diagnosed with two or more cancers around the same time. Published literature reported the incidence of multiple primaries is in the range of 2% - 17%. The risk factors for MPMs are smoking, chronic alcoholism, genetic factors and previous treatment of cancer using radiotherapy that may lead to the development of other cancer. This case report describes a rare and unfortunate case of middle-aged Malaysian Chinese lady diagnosed with adenocarcinoma of the uterus and around the same time she had a recurrent nasopharyngeal carcinoma which was first diagnosed and treated 11 years ago. There were no clear risk factors identified in her and she defaulted follow up which eventually led to a fatal complication in which the nasopharyngeal cancer caused massive bleeding in her and she finally succumbed to the complication despite emergency resuscitations. 展开更多
关键词 Multiple PRIMARY MALIGNANCIES
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八段锦联合情志护理对恶性肿瘤患者癌因性疲乏及负性情绪的影响 预览
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作者 邱萍 王宝宽 陈丽 《中西医结合护理(中英文)》 2019年第1期82-85,共4页
目的探讨八段锦联合情志护理对恶性肿瘤患者癌因性疲乏(CRF)及负性情绪的干预效果。方法将71例确诊为恶性肿瘤且评定存在CRF的患者随机分为对照组(n=36)和观察组(n=35),对照组患者给予常规护理,观察组患者在对照组基础上实施八段锦和中... 目的探讨八段锦联合情志护理对恶性肿瘤患者癌因性疲乏(CRF)及负性情绪的干预效果。方法将71例确诊为恶性肿瘤且评定存在CRF的患者随机分为对照组(n=36)和观察组(n=35),对照组患者给予常规护理,观察组患者在对照组基础上实施八段锦和中医情志护理进行干预。结果干预4周后,观察组患者CRF程度明显轻于对照组,差异有统计学意义(Z=-2.561,P=0.010);Zung焦虑自评量表(SAS)评分、Zung抑郁自评量表(SDS)评分均显著低于对照组,差异有统计学意义(P<0.05)。结论八段锦联合情志护理可以改善恶性肿瘤患者CRF和焦虑、抑郁症状,提高患者的生活质量。 展开更多
关键词 八段锦 情志护理 恶性肿瘤 癌因性疲乏 焦虑 抑郁 中医护理
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De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature 预览
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作者 Tommaso Maria Manzia Roberta Angelico +8 位作者 Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第35期5356-5375,共20页
BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with cr... BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of toleran 展开更多
关键词 Pediatric LIVER TRANSPLANT IMMUNOSUPPRESSION WEANING Clinical operational tolerance Adult LIVER TRANSPLANT Graft REJECTION Immune system De novo MALIGNANCIES IMMUNOSUPPRESSION minimization Cancer
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北京市西城区月坛社区卫生服务中心恶性肿瘤患者门诊就诊现状分析
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作者 季燕 陈雪 丁静 《中华全科医师杂志》 2019年第10期977-981,共5页
目的了解北京市西城区月坛社区卫生服务中心肿瘤患者门诊就诊情况及影响因素.方法回顾性选取2016年1月至2017年12月在北京市月坛社区卫生服务中心就诊的恶性肿瘤患者209例为研究对象.根据是否有固定就诊医师,分为固定医师就诊组(92例)... 目的了解北京市西城区月坛社区卫生服务中心肿瘤患者门诊就诊情况及影响因素.方法回顾性选取2016年1月至2017年12月在北京市月坛社区卫生服务中心就诊的恶性肿瘤患者209例为研究对象.根据是否有固定就诊医师,分为固定医师就诊组(92例)和非固定医师就诊组(117例)并分析其影响因素.结果209例恶性肿瘤患者中,男性65例(31.10%),女性144例(68.90%);年龄(69.4±10.0)岁;在合并慢性病方面,合并高血压114例(54.55%)、2型糖尿病52例(24.88%)、血脂异常40例(19.24%).209例患者平均就诊(23.16±3.86)次,固定医师就诊组就诊次数[(27.72±2.67)次]高于非固定医师就诊组[(22.93±2.61)次],差异有统计学意义(χ^2=2.592,P=0.01);107例家医签约者平均就诊(25.64±7.60)次,固定医师就诊组就诊次数[(32.10±2.10)次]高于非固定医师就诊组[(13.56±3.34)次],差异有统计学意义(χ^2=3.938,P<0.01).多因素logistic回归分析显示,高血压(OR=0.445,95%CI:0.213~0.971)、签约《家庭医生式服务》(OR=0.212,95%CI:0.104~0.435)是患者固定医师就诊的独立影响因素.结论月坛社区卫生服务中心恶性肿瘤患者门诊就诊情况达《国家基本公共卫生服务规范》对慢性病的随访要求,固定医师就诊者就诊次数高于非固定医师就诊,合并高血压、签约《家庭医生式服务》者固定医师就诊比率高. 展开更多
关键词 肿瘤 恶性 门诊医疗 家庭医生签约服务
Submental island flap reconstruction for carcinoma of the oral cavity: Experience in 30 cases
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作者 Pradeep Pradhan Swagatika Samal +2 位作者 Dillip Kumar Samal Chappity Preetam Pradipta Kumar Parida 《世界耳鼻咽喉头颈外科杂志(英文)》 2019年第2期65-70,共6页
Objective:The submental flap can be utilized for soft tissue reconstruction in oral cavity malignancies because due to its close approximation to the surgical site,fewer donor site morbidity and the cost effectiveness... Objective:The submental flap can be utilized for soft tissue reconstruction in oral cavity malignancies because due to its close approximation to the surgical site,fewer donor site morbidity and the cost effectiveness of the procedure.Methods:A total of 30 patients with squamous cell carcinoma of the oral cavity were included in the study from July 2012 to August 2015 in a tertiary care referral hospital.Patients with clinical staging Ⅰ/Ⅱ/Ⅲ (T1/T2/T3,N0) oral malignancy were included in the study.Patients with nodal metastasis irrespective of the stage of disease and patients with chronic medical illness/revision cases were excluded from the study.Submental island flap was utilized for the reconstruction of the soft tissue defect in each patient.Patients were followed at monthly interval till 6 months in the postoperative period.Results:The buccal mucosa (12 patients),tongue (10 patients) and floor of mouth (8 patients) were the subsites in the oral cavity.Partial and complete skin necrosis was found in 4 and 2 patients respectively.Postoperative chemoradiation was required in 5 patients.None of the patients had loco regional recurrence till 6 months of follow-up.Conclusion:The submental island flap is considered to be the reliable option for the soft tissue reconstruction in oral cancer because of dependent vascular pedicle,less donor site morbidity and the lower cost compared to the free flaps,often preferred in patients with a lower socioeconomic condition. 展开更多
关键词 ORAL MALIGNANCIES SUBMENTAL ISLAND FLAP Surgical technique OUTCOME
Diagnostic and Prognostic Value of Plasma Factor V Activity and Parameters in Thrombin Generation for Disseminated Intravascular Coagulation in Patients with Hematological Malignancies 预览
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作者 Hai-ming K0U Xiao-ping ZHANG +3 位作者 Man-zhi WANG Jun DENG Heng MEI Yu HU 《当代医学科学(英文)》 SCIE CAS 2019年第4期546-550,共5页
In this study,we used plasma factor V activity and parameters of the thrombin generation test to discuss their diagnostic and prognostic value for disseminated intravascular coagulation (DIC) in patients with hematolo... In this study,we used plasma factor V activity and parameters of the thrombin generation test to discuss their diagnostic and prognostic value for disseminated intravascular coagulation (DIC) in patients with hematological malignancies.A total of 164 patients who were diagnosed with hematological malignancies in the Department of Hematology,Union Hospital,between Apr 2014 and Dec.2014 were enrolled in this study.There were 131 patients in the study group and 33 patients in the control group in terms of the laboratory results for DIC.The patients in the study group were divided into a DIC subgroup (n=59) and a non-DIC subgroup (n=72) based on the International Society of Thrombosis and Hemostasis (ISTH) Integral System,and they were divided into four subgroups [score ≤3 (n=35),score=4 (n=37),score=5 (n=47),and score >6 (n=12)] according to ISTH scores.Using 28-day mortality as the endpoint,the patients in the study group were divided into a survival subgroup (n=111) and a non-survival subgroup (n=20).The results showed that the plasma factor V activity was significantly weaker,and lag time and time to peak were significantly shorter in the study group than in the control group (P<0.01).The factor V activity,peak and endogenous thrombin potential (ETP) were significantly decreased in the DIC subgroup as compared with those in the non-DIC subgroup (P<0.01).Among factor V activity,lag time,peak,ETP,and ttPeak,only the factor V activity was significantly decreased in the nonsurvival subgroup compared with the survival subgroup (P<0.01).With the increase in ISTH score,the ETP and peak decreased gradually.The binary logistic regression analysis revealed that PLT,D-dimer,factor V activity and ETP had linear relationship with DIC diagnosed by ISTH Integral System.Using DIC diagnosed by ISTH Integral System as the endpoint,the area under curve (AUC) of factor V activity was found to be similar to that of blood platelet count (PLT) and prothrombin time (PT).In conclusion,factor V activity,ETP and peak had diagnostic value 展开更多
关键词 DISSEMINATED INTRAVASCULAR coagulation HEMATOLOGICAL MALIGNANCIES factor V ACTIVITY THROMBIN generation test
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FHL2在消化系统恶性肿瘤中的研究进展 预览
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作者 朱翠翠 康海锋 +3 位作者 仇建伟 钱俊波 刘宏斌 张冬梅 《世界华人消化杂志》 CAS 2019年第17期1083-1087,共5页
FHL2是一种参与信号转导和基因转录的支架蛋白,具有FHL蛋白典型的结构特征.FHL2含有四个半LIM结构域,不同的LIM结构域可以与不同的蛋白质结合,从而激活或者抑制转录因子如P53、血清应答因子等的活性,进而影响肿瘤的发生发展.既往研究发... FHL2是一种参与信号转导和基因转录的支架蛋白,具有FHL蛋白典型的结构特征.FHL2含有四个半LIM结构域,不同的LIM结构域可以与不同的蛋白质结合,从而激活或者抑制转录因子如P53、血清应答因子等的活性,进而影响肿瘤的发生发展.既往研究发现,FHL2在肿瘤发生发展中具有复杂的生物学作用,在不同类型肿瘤中发挥促癌或抑癌的作用.本文就FHL2在消化系统恶性肿瘤中的研究进展作一概述. 展开更多
关键词 FHL2 消化系统 恶性肿瘤
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Application of robot-assisted laparoscopic pelvic exenteration in treating gynecologic malignancies
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作者 Qi-Yu Yang Jun-Ying Tang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第8期976-979,共4页
Introduction Pelvic exenteration(PE)refers to the en bloc resection of the involved pelvic organs along with pelvic reconstruction so as to enhance the survival rate for tumor patients.First reported by Brunschwig in ... Introduction Pelvic exenteration(PE)refers to the en bloc resection of the involved pelvic organs along with pelvic reconstruction so as to enhance the survival rate for tumor patients.First reported by Brunschwig in 1948,[1]PE has thereafter been utilized to treat rectal cancer,bladder cancer,prostate cancer,and cervical cancer as a curative or palliative treatment for advanced or recurrent malignancies.It is critical to carry out surgical resection of all the involved tumor lesions so as to prolong the overall survival(OS)of patients;nonetheless,such medical manipulation will induce various complications.For patients undergoing radiotherapy in the initial treatment,the increased tissue fragility,together with inflammation,has become trouble intraoperatively. 展开更多
关键词 GYNECOLOGIC MALIGNANCIES ROBOT-ASSISTED LAPAROSCOPIC PELVIC EXENTERATION PELVIC exenteration(PE)
踩球运动对妇科恶性肿瘤患者术后下肢血流动力学的影响 预览
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作者 于秀丽 张赫 +4 位作者 王浩东 朴丽 丛云凤 孟薇 刘玉锦 《护理学杂志》 CSCD 北大核心 2019年第17期33-35,共3页
目的探讨踩球运动对妇科恶性肿瘤术后患者下肢深静脉血流动力学的影响,为临床预防下肢静脉血栓形成提供参考。方法将40例妇科恶性肿瘤术后患者随机分为对照组和观察组各20例,在常规治疗和护理的基础上,对照组麻醉清醒后指导患者床上进... 目的探讨踩球运动对妇科恶性肿瘤术后患者下肢深静脉血流动力学的影响,为临床预防下肢静脉血栓形成提供参考。方法将40例妇科恶性肿瘤术后患者随机分为对照组和观察组各20例,在常规治疗和护理的基础上,对照组麻醉清醒后指导患者床上进行踝泵运动,观察组麻醉清醒后指导患者床上进行踩球运动。于首次运动前后及术后第3天观察两组下肢股静脉血流峰速及血流平均速度情况。结果术后首次运动不同时间点及术后第3天两组下肢血流峰速和血流平均速度比较,差异无统计学意义(均P>0.05)。组内单因素重复测量方差分析示,两组运动前后血流峰速和血流平均速度比较,差异有统计学意义(均P<0.01)。踩球运动或踝泵运动后立即及30min下肢静脉血流峰速和血流速度显著高于静息状态(均P<0.01)。结论对妇科恶性肿瘤术后患者行早期踩球运动可提高下肢血流速度,促进下肢血液回流,可以部分替代踝泵运动或作为踝泵运动的有益补充,作为预防下肢静脉血栓形成的干预措施。 展开更多
关键词 妇科 恶性肿瘤 踩球运动 踝泵运动 血流动力学 下肢静脉血栓
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Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study
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作者 Ling Wang Ying Wang +16 位作者 Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang 《医学前沿:英文版》 CAS CSCD 2019年第3期365-377,共13页
Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish ... Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. 展开更多
关键词 invasive FUNGAL diseases HEMATOLOGICAL MALIGNANCIES CHEMOTHERAPY risk score PROPHYLAXIS
Co-occurrence of IPMN and malignant IPNB complicated by a pancreatobiliary fistula:A case report and review of the literature 预览
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作者 Xu Ren Chun-Lan Zhu +3 位作者 Xu-Fu Qin Hong Jiang Tian Xia Yong-Ping Qu 《世界临床病例杂志》 2019年第1期102-108,共7页
BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is pathologically similar to intraductal papillary mucinous neoplasm(IPMN).However,there are several significant differences between them.The rate of IPM... BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is pathologically similar to intraductal papillary mucinous neoplasm(IPMN).However,there are several significant differences between them.The rate of IPMN associated with extrapancreatic malignancies has been reported to range from 10%-40%,and it may occasionally be complicated with the presence of fistulas.IPMN associated with malignant IPNB is extremely rare and only nine cases have been reported in the literature.CASE SUMMARY We report a 52-year-old man who presented with recurrent cholangitis for nine months.Computed tomography and magnetic resonance cholangiopancreatography showed the common bile duct stricture with dilated pancreatobiliary duct without other abnormal findings.The underlying pathogenesis could not be identified based on the radiologic images.Endoscopic retrograde cholangiopancreatography revealed a pancreatobiliary fistula with dilated main pancreatic duct,biliary stricture with dilated biliary tree,and mucus discharge from the enlarged orifice of the major papilla.The patient underwent SpyGlass cholangiopancreatoscopy due to a suspected mucin-producing biliary neoplasm and indeterminate main pancreatic duct dilatation.Multiple papillary growing neoplasms with vascular images,with the extent of lesions spreading in the biliopancreatic ductal lumens,were identified by SpyGlass.In addition,the presence of a pancreatobiliary fistula was also identified.The patient was diagnosed as having benign IPMN and malignant IPNB with focal invasion by postoperative pathology.Furthermore,varying histological subtypes were present in both IPMN and IPNB.Pylorus-preserving pancreaticoduodenectomy was performed on the patient with excellent results during the 52 month followup period.CONCLUSION We deemed that pancreatography and SpyGlass allowed for an efficient diagnosis of IPMN with pancreatobiliary fistula,whereas the etiology could not be identified by radiologic imaging. 展开更多
关键词 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM of the pancreas INTRADUCTAL PAPILLARY NEOPLASM of the bile duct Extrapancreatic malignancies CO-OCCURRENCE Pancreatobiliary fistula SpyGlass cholangiopancreatoscopy Endoscopic retrograde cholangiopancreatography Case report
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Prostate cancer: molecular and cellular mechanisms and their implications in therapy resistance and disease progression
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作者 Ninghan Feng Jiaoti Huang 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期213-214,共2页
Prostate cancer is among the most common malignancies in Western countries, and its incidence is rapidly rising in Asia where it was traditionally considered an uncommon tumor. Our understanding of the disease and man... Prostate cancer is among the most common malignancies in Western countries, and its incidence is rapidly rising in Asia where it was traditionally considered an uncommon tumor. Our understanding of the disease and management strategies continue to evolve. The first revolution of its treatment was in the 1940s when hormonal therapy was used to treat patients. 展开更多
关键词 PROSTATE cancer is among MALIGNANCIES in WESTERN TREAT patients
预防妇科恶性肿瘤患者术后留置导尿管感染的护理干预 预览
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作者 赵玲 《实用临床医药杂志》 CAS 2019年第4期113-115,共3页
目的探讨护理干预在预防妇科恶性肿瘤患者术后留置导尿管感染中的应用效果。方法将2016年3月—2017年2月妇科恶性肿瘤患者133例设置为对照组,采取常规护理干预,选取2017年3月—2018年2月收治妇科恶性肿瘤行手术治疗患者147例为干预组。... 目的探讨护理干预在预防妇科恶性肿瘤患者术后留置导尿管感染中的应用效果。方法将2016年3月—2017年2月妇科恶性肿瘤患者133例设置为对照组,采取常规护理干预,选取2017年3月—2018年2月收治妇科恶性肿瘤行手术治疗患者147例为干预组。比较2组患者术后留置导尿不同时间段发生导尿管感染概率、平均留置导尿时间、住院时间、并发症发生率及护理干预前后患者生活质量。结果干预组患者在术后不同时间段导尿管感染率显著低于对照组;干预组平均留置导尿时间、住院时间及并发症显著少于对照组;护理干预后2组患者的生活质量均有所改善,且干预组显著优于对照组(P<0.05)。结论妇科恶性肿瘤术后患者采取护理干预,可有效降低患者术后尿路感染率,缩短平均留置导尿及住院时间,减少术后并发症的发生,提高患者护理干预后的生活质量。 展开更多
关键词 护理干预 妇科 恶性肿瘤 术后留置尿管感染
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无意体质量减轻的合理处理 预览
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作者 刘文忠 《胃肠病学》 2018年第10期577-579,共3页
无意体质量减轻是临床常见症状之一,具有潜在严重的临床意义,有许多潜在的病因和特殊因素需要考虑。这些患者的全面评估应基于病史以及体格检查和实验室检查中发现的相关结果。本文的目的是讨论无意体质量减轻的临床重要性、潜在病因和... 无意体质量减轻是临床常见症状之一,具有潜在严重的临床意义,有许多潜在的病因和特殊因素需要考虑。这些患者的全面评估应基于病史以及体格检查和实验室检查中发现的相关结果。本文的目的是讨论无意体质量减轻的临床重要性、潜在病因和合理处理。 展开更多
关键词 体质量减轻 无意 病因 评估 恶性肿瘤 预后
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2014年上海市恶性肿瘤发病和死亡特征分析 预览 被引量:22
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作者 鲍萍萍 龚杨明 +9 位作者 彭鹏 张敏璐 吴春晓 王春芳 顾凯 向詠梅 施亮 邹珍 施燕 付晨 《中国癌症杂志》 CSCD 北大核心 2018年第3期161-176,共16页
背景与目的:恶性肿瘤已成为严重威胁上海市居民健康的重大公共卫生问题。该研究旨在描述和分析2014年上海市恶性肿瘤发病与死亡情况。方法:根据上海市恶性肿瘤病例报告登记系统收集的恶性肿瘤发病资料,按地区、性别分层,分别计算恶性... 背景与目的:恶性肿瘤已成为严重威胁上海市居民健康的重大公共卫生问题。该研究旨在描述和分析2014年上海市恶性肿瘤发病与死亡情况。方法:根据上海市恶性肿瘤病例报告登记系统收集的恶性肿瘤发病资料,按地区、性别分层,分别计算恶性肿瘤发病与死亡粗率、标化率、前10位恶性肿瘤发病与死亡顺位和构成等,应用Joinpoint统计软件分析2002—2014年上海市恶性肿瘤发病和死亡趋势,估算总体和分阶段的年度变化百分比(annual percentage change,APC)。采用Segi’s世界标准人口年龄构成计算标化率。结果:2014年上海市共报告恶性肿瘤新发病例68 541例,死亡病例37 242例。病理学诊断比例为79.49%,只有死亡医学证明书比例为0.04%,死亡发病比为0.54。上海市恶性肿瘤粗发病率为477.79/10万,标化发病率为223.57/10万,男性标化发病率低于女性,市区低于郊区。恶性肿瘤发病在40岁以后快速上升,在80~84岁年龄组达到高峰。全市发病前10位恶性肿瘤依次为肺癌、结直肠癌、甲状腺癌、胃癌、乳腺癌、肝癌、前列腺癌、胰腺癌、脑和中枢神经系统肿瘤以及膀胱癌,前10位恶性肿瘤占全部恶性肿瘤发病的75.89%。全市恶性肿瘤粗死亡率为259.61/10万,标化死亡率为95.73/10万,男性标化死亡率高于女性,市区和郊区基本持平。死亡率在45岁以后快速上升,在≥85岁年龄组达到高峰。死亡前10位恶性肿瘤依次为肺癌、结直肠癌、胃癌、肝癌、胰腺癌、乳腺癌、食管癌、胆囊癌、前列腺癌以及脑和中枢神经系统肿瘤,前10位恶性肿瘤占全部恶性肿瘤死亡的78.12%。2002—2014年,上海市女性所有部位的恶性肿瘤标化发病率呈明显上升趋势(APC为2.17%,P〈0.001),男性标化发病率则较为稳定。男性和女性所有部位的恶性肿瘤标化死亡率均呈明显下降趋势(APC分别为-0.82%和-0.76%,P〈0.05)。结论:肺癌� 展开更多
关键词 恶性肿瘤 发病率 死亡率 趋势 上海
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miRNA-181家族与恶性肿瘤关系的研究进展 预览 被引量:2
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作者 韩宝娟 庞慧 《现代肿瘤医学》 CAS 2018年第3期459-462,共4页
近年来microRNA-181(miR-181)家族已经成为生物医学界所关注的热点之一。许多研究表明,多种恶性肿瘤(肝癌、胃癌、乳腺癌、胰腺癌、肺癌、胶质瘤、白血病等)中miR-181家族表达异常。目前已证实miR-181家族存在众多靶点,miR-181家... 近年来microRNA-181(miR-181)家族已经成为生物医学界所关注的热点之一。许多研究表明,多种恶性肿瘤(肝癌、胃癌、乳腺癌、胰腺癌、肺癌、胶质瘤、白血病等)中miR-181家族表达异常。目前已证实miR-181家族存在众多靶点,miR-181家族作用于其各自的靶点,进而调控恶性肿瘤细胞的增殖、分化、凋亡、侵袭、转移,以及参与恶性肿瘤的耐药等,miR-181家族已经成为众多恶性肿瘤的新型诊断标志物及治疗的靶点。 展开更多
关键词 miR-181家族 恶性肿瘤 进展
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对血清及胸腔积液中细胞因子和肿瘤标志物进行检测在鉴别诊断良恶性胸腔积液中的价值 预览
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作者 章志华 栗爱珍 +2 位作者 杨永辉 安晓颖 李幸彬 《当代医药论丛》 2018年第10期194-195,共2页
目的:探讨对血清及胸腔积液中细胞因子和肿瘤标志物进行检测在鉴别诊断良恶性胸腔积液中的价值。方法:选取2015年1月至2017年11月期间河北省胸科医院收治的46例结核性胸膜炎患者和44例肺癌患者作为研究对象。将其中的46例结核性胸膜... 目的:探讨对血清及胸腔积液中细胞因子和肿瘤标志物进行检测在鉴别诊断良恶性胸腔积液中的价值。方法:选取2015年1月至2017年11月期间河北省胸科医院收治的46例结核性胸膜炎患者和44例肺癌患者作为研究对象。将其中的46例结核性胸膜炎患者设为结核组,将其中的44例肺癌患者设为肺癌组。检测两组患者血清及胸腔积液中的瘦素(LEP)、肿瘤坏死因子-α(TNF-α)、癌胚抗原(CEA)、白介素-6(IL-6)及C-反应蛋白(CPR)的水平。然后比较两组患者的检测结果。结果:检测的结果显示,肺癌组患者血清和胸腔积液中LEP、TNF-α、CEA的水平均高于结核组患者,其血清和胸腔积液中IL-6的水平均低于结核组患者(P〈0.05)。两组患者血清和胸腔积液中CPR的水平相比差异均无统计学意义(P〉0.05)。结论:检测胸腔积液患者血清和胸腔积液中的细胞因子和肿瘤标志物,可有效地鉴别其胸腔积液的性质。 展开更多
关键词 肿瘤标志物 细胞因子 血清 胸腔积液 结核性胸膜炎 肺癌
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