The tenth BRICS Summit was held in Johannesburg,South Africa in 2018,which attracted attention from the whole world.Especially,it is of great importance to the BRICS nations,for it is the first ten years of BRICS,whic...The tenth BRICS Summit was held in Johannesburg,South Africa in 2018,which attracted attention from the whole world.Especially,it is of great importance to the BRICS nations,for it is the first ten years of BRICS,which marks its growth.Meanwhile,this year the Trump administration imposed more strict policies on protectionism.Particularly,the trade war between China and the United States is so intensive.China,as the core member of BRICS has great clout on BRICS,so the trade war between China and US also arouse a heat discussion among the BRICS nations.During the Summit,CGTN invited experts from the five BRICS nations to discuss related topics.Systemic Functional Linguistics,as one of the most influential branches of Linguistics,was firstly established by M.A.K.Halliday,and it has been greatly developed over the past decades.Interpersonal meaning is one of the three meta-functions,which focuses on how addressers use language to communicate,establish and maintain relationships with addressees,and express their opinions.Mood and modality are two basic resources to the realization of interpersonal meaning.Mood is used to represent the interaction of the language users,while modality reflects the utterers’attitudes and judgments.The paper discusses the three aspects of modality:modal operators,modal adjuncts and metaphors of modality.The paper applies the modality system to the analysis of the transcript of BRICS TALK.The author selects the experts’speeches on the trade war between China and US as the data.The research questions are as followed:(1)the characteristics of the modality resources appeared in their talks;(2)the BRICS nations attitudes and stance on trade war and America’s protectionism.展开更多
Background:Post-liver transplantation(LT)hepatocellular carcinoma(HCC)recurrence still occurs in approximately 20%of patients and drastically affects their survival.This study aimed to evaluate the efficacy of various...Background:Post-liver transplantation(LT)hepatocellular carcinoma(HCC)recurrence still occurs in approximately 20%of patients and drastically affects their survival.This study aimed to evaluate the efficacy of various treatments for recurrent HCC after LT in a Chinese population.Methods:A total of 64 HCC patients with tumor recurrence after LT were enrolled in this study.Univariate and multivariate analyses were performed to identify factors affecting post-recurrence survival.Results:Of the 64 patients with recurrent HCC after LT,those who received radical resection followed by nonsurgical therapy had a median overall survival(OS)of 20.9 months after HCC recurrence,significantly superior to patients who received only nonsurgical therapy(9.4 months)or best supportive care(2.4 months).The one-and two-year OS following recurrence was favorable for patients receiving radical resection followed by nonsurgical therapy(93.8%,52.6%),poor for patients receiving only nonsurgical therapy(30.8%,10.8%),and dismal for patients receiving best supportive care(0%,0%;overall P<0.001).Median OS in sorafenib-tolerant patients treated with lenvatinib was 19.5 months,far surpassing the patients that discontinued sorafenib or were treated with regorafenib after sorafenib failure(12 months,P<0.001).Compared with tacrolimus-based immunosuppressive therapy,OS was significantly increased with sirolimus-based therapy at one and two years after HCC recurrence(P=0.035).Multivariate analysis showed radical resection combined with nonsurgical therapy for recurrent HCC and sorafenib-lenvatinib sequential therapy were independent favorable factors for post-recurrence survival.Conclusions:Aggressive surgical intervention in well-selected patients significantly improves OS after recurrence.A multidisciplinary treatment approach is required to slow down disease progression for patients with unresectable recurrent HCC.展开更多
Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy...Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic.展开更多
文摘The tenth BRICS Summit was held in Johannesburg,South Africa in 2018,which attracted attention from the whole world.Especially,it is of great importance to the BRICS nations,for it is the first ten years of BRICS,which marks its growth.Meanwhile,this year the Trump administration imposed more strict policies on protectionism.Particularly,the trade war between China and the United States is so intensive.China,as the core member of BRICS has great clout on BRICS,so the trade war between China and US also arouse a heat discussion among the BRICS nations.During the Summit,CGTN invited experts from the five BRICS nations to discuss related topics.Systemic Functional Linguistics,as one of the most influential branches of Linguistics,was firstly established by M.A.K.Halliday,and it has been greatly developed over the past decades.Interpersonal meaning is one of the three meta-functions,which focuses on how addressers use language to communicate,establish and maintain relationships with addressees,and express their opinions.Mood and modality are two basic resources to the realization of interpersonal meaning.Mood is used to represent the interaction of the language users,while modality reflects the utterers’attitudes and judgments.The paper discusses the three aspects of modality:modal operators,modal adjuncts and metaphors of modality.The paper applies the modality system to the analysis of the transcript of BRICS TALK.The author selects the experts’speeches on the trade war between China and US as the data.The research questions are as followed:(1)the characteristics of the modality resources appeared in their talks;(2)the BRICS nations attitudes and stance on trade war and America’s protectionism.
基金the grants from National S&T Major Project(2017ZX10203205)the Medical Science and Technology Project of Zhejiang Province(2014KYA082)+1 种基金the Fundamental Research Funds for the Central Universities(2018FZA7002)the Shulan Talent Foundation.
文摘Background:Post-liver transplantation(LT)hepatocellular carcinoma(HCC)recurrence still occurs in approximately 20%of patients and drastically affects their survival.This study aimed to evaluate the efficacy of various treatments for recurrent HCC after LT in a Chinese population.Methods:A total of 64 HCC patients with tumor recurrence after LT were enrolled in this study.Univariate and multivariate analyses were performed to identify factors affecting post-recurrence survival.Results:Of the 64 patients with recurrent HCC after LT,those who received radical resection followed by nonsurgical therapy had a median overall survival(OS)of 20.9 months after HCC recurrence,significantly superior to patients who received only nonsurgical therapy(9.4 months)or best supportive care(2.4 months).The one-and two-year OS following recurrence was favorable for patients receiving radical resection followed by nonsurgical therapy(93.8%,52.6%),poor for patients receiving only nonsurgical therapy(30.8%,10.8%),and dismal for patients receiving best supportive care(0%,0%;overall P<0.001).Median OS in sorafenib-tolerant patients treated with lenvatinib was 19.5 months,far surpassing the patients that discontinued sorafenib or were treated with regorafenib after sorafenib failure(12 months,P<0.001).Compared with tacrolimus-based immunosuppressive therapy,OS was significantly increased with sirolimus-based therapy at one and two years after HCC recurrence(P=0.035).Multivariate analysis showed radical resection combined with nonsurgical therapy for recurrent HCC and sorafenib-lenvatinib sequential therapy were independent favorable factors for post-recurrence survival.Conclusions:Aggressive surgical intervention in well-selected patients significantly improves OS after recurrence.A multidisciplinary treatment approach is required to slow down disease progression for patients with unresectable recurrent HCC.
文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic.