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微液滴制备技术在功能化纳米载体构建中的应用
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作者 沈小钟 葛铭晨 +1 位作者 付泯宇 王亚晶 《中国医药工业杂志》 CAS CSCD 北大核心 2019年第2期148-157,共10页
以微流控芯片为基础的微液滴技术在制备结构和粒径均一的功能纳米载体方面具有独特优势。本文总结了目前利用微液滴技术和不同制备材料构建的具有不同结构和功能的纳米载体在药物递送方面的研究进展。纳米载体主要包括纳米脂质体、聚合... 以微流控芯片为基础的微液滴技术在制备结构和粒径均一的功能纳米载体方面具有独特优势。本文总结了目前利用微液滴技术和不同制备材料构建的具有不同结构和功能的纳米载体在药物递送方面的研究进展。纳米载体主要包括纳米脂质体、聚合物纳米粒、固体脂质纳米粒、杂化纳米复合物、Janus纳米粒等。 展开更多
关键词 微流控 微液滴 脂质体 纳米粒 Janus纳米粒
A tri-layer approach to controlling nanopore formation in oxide supports
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作者 Abha A.Gosavi James L.Hedrick +2 位作者 Peng-Cheng Chen Justin M.Notestein Chad A.Mirkin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第6期1223-1228,共6页
A novel tri-layer approach for immobilizing metal nanoparticles in SiO2 supports is presented.In this work,we show that under rapid heating to temperatures of approximately 1,000 ℃,metal nanoparticles less than 15 nm... A novel tri-layer approach for immobilizing metal nanoparticles in SiO2 supports is presented.In this work,we show that under rapid heating to temperatures of approximately 1,000 ℃,metal nanoparticles less than 15 nm in size will entrench in the SiO2 layer on a silicon wafer to create pores as deep as 250 nm.We studied and characterized this entrenching behavior and subsequent nanopore formation for a wide variety of metal nanoparticles,including Au,Ag,Pt,Pd,and Cu.We also demonstrate that an Al2O3 layer acts as a barrier to such pore formation.Thus,by creating a tri-layer architecture consisting of SiO2 on Al2O3 on silicon wafers,we can control the depth to which nanoparticles entrench between 3-5 nm.This small range allows one to entrench particles for the purpose of immobilization but still present them above the surface.The two advances of moving into the sub-15 nm size regime and of controlled particle immobilization through entrenchment have important implications in studying site-isolated and stabilized metal nanoparticles for applications in sensing,separations,and catalysis. 展开更多
关键词 NANOPORE formation NANOPARTICLE ENTRENCHMENT NANOPARTICLE STABILIZATION atomic force MICROSCOPY Au nanoparticles
纳米杂化有机硅丙烯酸防腐疏水树脂合成及应用 预览
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作者 周涛 李欢 +3 位作者 程琳 段凤仪 杨其儒 孔江榕 《徐州工程学院学报:自然科学版》 CAS 2019年第2期1-9,共9页
文章通过有机硅和纳米粒子双重改性提高丙烯酸树脂的综合性能.采用水解缩合法制备有机硅预聚体,再将其通过自由基聚合改性丙烯酸树脂,并在树脂中加入改性的纳米粒子作为填料.实验表明:有机硅成功与丙烯酸单体发生共聚;有机硅改性有效提... 文章通过有机硅和纳米粒子双重改性提高丙烯酸树脂的综合性能.采用水解缩合法制备有机硅预聚体,再将其通过自由基聚合改性丙烯酸树脂,并在树脂中加入改性的纳米粒子作为填料.实验表明:有机硅成功与丙烯酸单体发生共聚;有机硅改性有效提高了丙烯酸树脂耐热性和疏水性;复合纳米粒子比使用单一纳米SiO2或TiO2粒子更能在保证涂层透明性同时保证紫外屏蔽性能,纳米粒子能进一步提高疏水性,并且SAR3涂层接触角达到108.4°;纳米颗粒添加剂能显著提高防腐性能.SAR3和SAR5的涂层,在3.5%NaCl溶液中经过1800h浸泡后涂层电阻仍保持在109Ω·cm2以上,具有较好防护性能. 展开更多
关键词 耐候缓释 有机硅丙烯酸树脂 纳米粒子 复合涂料
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A rapid and operator-safe powder approach for latent fingerprint detection using hydrophilic Fe3O4@SiO2-CdTe nanoparticles
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作者 Zhaolei Wang Xue Jiang +2 位作者 Wenbin Liu Guolin Lu Xiaoyu Huang 《中国科学:化学英文版》 SCIE EI CAS CSCD 2019年第7期889-896,共8页
A new kind of bifunctional magnetic-fluorescent nanoparticles(NPs)with abundant carboxyls on the surface has been prepared by covalently combining glutathiose(GSH)-modified CdTe quantum dots(QDs)with Fe3O4@SiO2NPs.The... A new kind of bifunctional magnetic-fluorescent nanoparticles(NPs)with abundant carboxyls on the surface has been prepared by covalently combining glutathiose(GSH)-modified CdTe quantum dots(QDs)with Fe3O4@SiO2NPs.The silica-coated Fe3O4NPs were functionalized with amino groups by(3-aminopropyl)triethoxysilane to provide Fe3O4@SiO2-NH2NPs,which was then chemically conjugated with GSH-modified CdTe QDs to form bifunctional magnetic-fluorescent NPs,Fe3O4@SiO2-NH-CO-CdTe-QDs NPs.The properties and morphologies of Fe3O4@SiO2-NH-CO-CdTe-QDs NPs were investigated by FTIR,X-ray diffraction,transmission electron microscopy(TEM),absorption and fluorescence spectroscopy and vibrating sample magnetometry.TEM images display that Fe3O4@SiO2-NH-CO-CdTe-QDsNPs possess spherical core-shell structure with a uniform size about 50 nm.The bifunctional NPs were found to exhibit good magnetic and strong fluorescent properties favorable for their application in the detection of latent fingerprints.Furthermore,the carboxyls on the surface of NPs have good absorptions with water in air and the residues of fingerprints so as to not only avoid dust flying to protect the health of operators,but also improve the efficiency of detection. 展开更多
关键词 FINGERPRINT magnetic NANOPARTICLE FLUORESCENCE quantum DOT
雷公藤甲素抗肿瘤新型给药系统研究进展
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作者 宋基正 刘宇灵 +4 位作者 林龙飞 马红星 付赛 王秀清 李慧 《中草药》 CAS CSCD 北大核心 2019年第5期1269-1275,共7页
雷公藤甲素具有广谱、高效的抗肿瘤活性,但其具有水溶性差、体内消除快和毒副作用强等缺点,限制了雷公藤甲素的临床应用。新型给药系统是靶向递送雷公藤甲素的理想载体,能够将其有效运送至肿瘤组织,提高对肿瘤的治疗效果,新型给药系统... 雷公藤甲素具有广谱、高效的抗肿瘤活性,但其具有水溶性差、体内消除快和毒副作用强等缺点,限制了雷公藤甲素的临床应用。新型给药系统是靶向递送雷公藤甲素的理想载体,能够将其有效运送至肿瘤组织,提高对肿瘤的治疗效果,新型给药系统在改善雷公藤甲素溶解度、降低其毒副作用、提高生物利用度等方面有良好的应用前景。综述近10年来基于脂质体、聚合物胶束、纳米粒的雷公藤甲素抗肿瘤新型给药系统的研究进展,以期为雷公藤甲素新型给药系统在抗肿瘤药物的开发和应用等方面提供参考。 展开更多
关键词 雷公藤甲素 新型给药系统 抗肿瘤 脂质体 聚合物胶束 纳米粒
果胶-酪蛋白酸钠纳米复合物的特性
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作者 张春兰 张璐璐 +2 位作者 谭慧林 陆健康 王丽玲 《食品工业》 CAS 北大核心 2019年第2期194-197,共4页
以果胶、酪蛋白酸钠为原料,在一定条件下制备果胶-酪蛋白酸钠纳米粒子复合物,对复合物特性进行表征。结果表明,随着pH (3.0~8.0)增大,果胶-酪蛋白酸钠复合物的带电量从-10.2 mV降低到-48.6 mV。pH在3.0~5.0范围内粒径较小,均在300 nm以... 以果胶、酪蛋白酸钠为原料,在一定条件下制备果胶-酪蛋白酸钠纳米粒子复合物,对复合物特性进行表征。结果表明,随着pH (3.0~8.0)增大,果胶-酪蛋白酸钠复合物的带电量从-10.2 mV降低到-48.6 mV。pH在3.0~5.0范围内粒径较小,均在300 nm以下,都是单峰,其粒径分布较集中。果胶-酪蛋白酸钠复合物表面疏水性在pH 4时为26.5μg,羰基含量为5.3μmol/g,均比酪蛋白酸钠的高,而游离巯基含量为6.2μmol/g,这为果胶-酪蛋白酸钠复合物的进一步利用提供理论依据。 展开更多
关键词 酪蛋白酸钠 果胶 纳米粒子
磁控溅射制备Cu-Al合金薄膜及光吸收性能研究 预览
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作者 王明腾 宋娟 +4 位作者 高宇浩 张力 侯贵华 关荣锋 杨子润 《盐城工学院学报:自然科学版》 CAS 2019年第1期6-11,共6页
为使沉积态Cu-Al合金薄膜有显著的表面等离子体共振(SPR)吸收峰,采用磁控溅射法分别制备了纯Cu、纯Al和Cu-Al合金薄膜,并采用X射线衍射仪、紫外-可见分光光度计对其物相和光吸收性能进行了测试。结果表明,不连续的较薄Cu膜在沉积态下可... 为使沉积态Cu-Al合金薄膜有显著的表面等离子体共振(SPR)吸收峰,采用磁控溅射法分别制备了纯Cu、纯Al和Cu-Al合金薄膜,并采用X射线衍射仪、紫外-可见分光光度计对其物相和光吸收性能进行了测试。结果表明,不连续的较薄Cu膜在沉积态下可观察到540 nm处的吸收峰,较厚的Cu膜通过在400℃下进行1 h热处理可在400 nm处获得微弱的吸收峰。沉积态的Al膜在可见光范围内无吸收峰,在热处理后,不连续的较薄Al膜可获得580 nm处的吸收峰,而较厚Al膜通过长时间热处理后可获得730 nm处的吸收峰。共溅射制得的较薄Cu-Al合金薄膜无须经过热处理,即可在可见光范围内获得吸收峰。 展开更多
关键词 Cu-Al合金薄膜 表面等离子体共振 纳米颗粒 热处理
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Carbon-based materials for photodynamic therapy: A mini-review
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作者 Di Lu Ran Tao Zheng Wang 《化学科学与工程前沿:英文版》 EI CAS CSCD 2019年第2期310-323,共14页
Carbbased materials have been extensively applied in photodynamic therapy owing to the unique optical characteristics, good biocompatibility and tunable systematic toxicity. This mini-review mainly focuses on the rece... Carbbased materials have been extensively applied in photodynamic therapy owing to the unique optical characteristics, good biocompatibility and tunable systematic toxicity. This mini-review mainly focuses on the recent application of carbbased materials including graphene, carbon nanotube, fullerene, corannulene, carbon dot and mesoporous carbon nanoparticle. The carbon-based materials can perform not only as photosensitizers, but also effective carriers for photosensitizers in photodynamic therapy, and its combined treatment. 展开更多
关键词 photodynamic therapy carbon-based materials graphene CARBON NANOTUBE FULLERENE CORANNULENE CARBON dot MESOPOROUS CARBON nanoparticle
Impacts of Wettability on Immiscible Fluid Flow Pattern-Microfluidic Chip Experiment 预览
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作者 Zheng Xianglei Jang Jaewon 《中国炼油与石油化工:英文版》 SCIE CAS 2019年第1期80-89,共10页
Immiscible fluid flow is frequently found in resource recovery or soil remediation. The flow pattern in the porous media is affected by the wettability of pore surface. In this study, quartz substrates and microfluidi... Immiscible fluid flow is frequently found in resource recovery or soil remediation. The flow pattern in the porous media is affected by the wettability of pore surface. In this study, quartz substrates and microfluidic chips are treated by silica nanoparticles(SNP) and triethoxy(octyl)silane(TES) to fabricate the water-wet and oil-wet surfaces. The wettability of the treated-surface is measured in term of contact angle for several combinations of surrounding fluid and a liquid droplet. The effect of the wettability on the fluid flow pattern is explored by injecting oil and water alternately into the surface-treated microfluidic chips. The results reveal that the SNP-coated quartz substrate shows strong water-wet property and the TES coating makes water-repellent/oil-wet surfaces. In addition, it is found that the maximum and minimum oil and water saturation during alternate injection of oil and water depends on the surface wettability of the microfluidic chips. The characteristics of the pore-scale fluid flow pattern are also described. 展开更多
关键词 WETTABILITY contact angle nanoparticle coating HYDROPHILIC HYDROPHOBIC microfluidic chip
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纳米金属有机框架材料在药物递送领域的应用
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作者 赖欣宜 王志勇 +1 位作者 郑永太 陈永明 《化学进展》 SCIE CAS CSCD 北大核心 2019年第6期783-790,共8页
金属有机框架材料(Metal-Organic Frameworks,MOFs)是一类由金属离子及有机配体自组装而成的多孔材料,具有孔隙率高、比表面积大和结构多样化等独特优点,广泛应用于气体储存、物质分离和催化等领域。纳米尺寸金属有机框架材料(Nanoscale... 金属有机框架材料(Metal-Organic Frameworks,MOFs)是一类由金属离子及有机配体自组装而成的多孔材料,具有孔隙率高、比表面积大和结构多样化等独特优点,广泛应用于气体储存、物质分离和催化等领域。纳米尺寸金属有机框架材料(Nanoscale Metal-Organic Frameworks,NMOFs)既保持了传统MOFs的规整性,也具有纳米颗粒的特殊性质,在生物医药领域中是绝佳的药物载体。相比于传统纳米药物载体,NMOFs与药物的结合方式丰富,展现了多种药物装载模式,可以满足不同药物的制备需求,也可引入不同功能分子优化性能。最近,有越来越多的研究报道了多功能化NMOFs应用于药物递送领域,并实现刺激响应性的可控释放。本文将着重对NMOFs材料作为药物载体负载抗癌药物、光敏剂和核酸的应用进展进行综述。 展开更多
关键词 金属有机框架材料 纳米颗粒 药物递送 抗癌药物 光敏剂 核酸
新型季铵盐纳米颗粒对金黄色葡萄球菌和铜绿假单胞菌生物膜抑制作用的研究
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作者 黄书满 赵玉林 +2 位作者 董栋 张亚倩 耿静 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2019年第4期326-331,共6页
目的:探讨低浓度氯化十六烷基吡啶(CPC)季铵盐纳米颗粒在体外对金黄色葡萄球菌和铜绿假单胞菌生物膜的抑制作用。方法:建立金黄色葡萄球菌ATCC25923和铜绿假单胞菌ATCC15692体外生物膜模型。制备低浓度(0.010%、0.025%和0.050%)CPC-季... 目的:探讨低浓度氯化十六烷基吡啶(CPC)季铵盐纳米颗粒在体外对金黄色葡萄球菌和铜绿假单胞菌生物膜的抑制作用。方法:建立金黄色葡萄球菌ATCC25923和铜绿假单胞菌ATCC15692体外生物膜模型。制备低浓度(0.010%、0.025%和0.050%)CPC-季铵盐纳米颗粒和CPC胶体溶液。用alamarBlue法分别在CPC作用5 min和2 h后检测金黄色葡萄球菌和铜绿假单胞菌游离及其生物膜的活性。应用激光扫描共聚焦显微镜(CLSM)观察CPC-季铵盐纳米颗粒与金黄色葡萄球菌和铜绿假单胞菌生物膜之间的相互作用。结果:低浓度(0.010%、0.025%和0.050%)CPC-季铵盐纳米颗粒和CPC胶体溶液对游离金黄色葡萄球菌和铜绿假单胞菌均有显著的抗菌作用(P<0.05),对金黄色葡萄球菌和铜绿假单胞菌生物膜分别作用5 min和2 h后同样具有显著的抗菌效果(P<0.05)。在CLSM研究中,金黄色葡萄球菌生物膜的面积明显减小,铜绿假单胞菌生物膜中的死菌明显增加。结论:低浓度的CPC-季铵盐纳米颗粒即可对金黄色葡萄球菌和铜绿假单胞菌游离菌及生物膜产生显著的杀伤作用,有望应用于慢性鼻窦炎的治疗。 展开更多
关键词 季铵盐纳米颗粒 金黄色葡萄球菌 铜绿假单胞菌 细菌生物膜
Highly active and stable supported Pd catalysts on ionic liquidfunctionalized SBA-15 for Suzuki–Miyaura cross-coupling and transfer hydrogenation reactions 预览
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作者 Etty N.Kusumawati Takehiko Sasaki 《绿色能源与环境:英文版》 CSCD 2019年第2期180-189,共10页
Highly dispersed palladium nanoparticles were synthesized in the presence of immobilized ionic liquid on mesoporous silica SBA-15.PdNPs(2.4 nm)_me-Im@SBA-15 catalyst was prepared by the reduction using NaBH4 as the re... Highly dispersed palladium nanoparticles were synthesized in the presence of immobilized ionic liquid on mesoporous silica SBA-15.PdNPs(2.4 nm)_me-Im@SBA-15 catalyst was prepared by the reduction using NaBH4 as the reducing agent with controlled feed rate and has been investigated as ligand-free catalyst for Suzuki–Miyaura cross-coupling reaction at room temperature in aqueous solution under air.PdNPs catalyst was also prepared in situ from PdCl4_me-Im@SBA-15 during the reaction and demonstrated high activity and stability towards nitrobenzene hydrogenation at high temperature.Both catalysts were reusable at least for four recycle processes without significant loss in activity with simple procedure.The catalysts were characterized by TEM,EXAFS,FTIR and XPS. 展开更多
关键词 Palladium nanoparticle Ionic liquid SBA-15 Suzuki–Miyaura CROSS-COUPLING HYDROGENATION
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Extending the operational lifetimes of all-direct electron transfer enzymatic biofuel cells by magnetically assembling and exchanging the active biocatalyst layers on stationary electrodes
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作者 Katharina Herkendell Andreas Stemmer Ran Tel-Vered 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第4期767-775,共9页
Enzymatic biofuel cells promise green power generation from a variety of natural resources, yet these systems all suffer from time-dependent degradati on effects, in particular progress! ng inactivation of enzymes, wh... Enzymatic biofuel cells promise green power generation from a variety of natural resources, yet these systems all suffer from time-dependent degradati on effects, in particular progress! ng inactivation of enzymes, which severely limit the operati on al lifetimes of such power sources. To extend operational lifetimes, we introduce a method to magnetically exchange exhausted enzymes for fresh ones. To this end, anodic and cathodic enzymes or enzyme cascades are immobilized on carbon coated magnetic nanoparticles. Under the action of suitable magnetic field gradie nts, these nano particles are assembled on the respective stati onary electrodes, or released from the electrodes for collection and subsequent excha nge. We dem on strate this method on a fructose/oxygen con suming biofuel cell emplo ying fructose dehydroge nase and bilirubin oxidase as well as on anodic and cathodic cascades employing fructose dehydrogenase/invertase and bilirubin oxidase/catalase, respectively. The en zyme-modified nan oparticles support direct electro n transfer bioelectrocatalytic curre nts by wiring the redox active cofactors to the carbonaceous coating and from there to the electrode surfaces. The facile injection, assembly, and removal of enzyme-modified magnetic nan oparticles along with fuel solutio n provides a promisi ng approach to exte nd the operati on al lifetime of enzymatic biofuel cells without the need for exchanging entire systems including chambers and electrodes. 展开更多
关键词 direct electron transfer magnetic nanoparticle ENZYMATIC BIOFUEL cell RECHARGE lifetime enzyme cascade
钴镍复合纳米颗粒的制备及其磁性能研究 预览
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作者 王新新 崔冬 +3 位作者 杨宇 陈红丽 李博 尚梦帆 《山东理工大学学报:自然科学版》 CAS 2019年第2期14-16,23共4页
以乙醇为溶剂,利用液相还原法制备不同比例的钴镍复合纳米颗粒,通过X射线衍射仪(XRD)、扫描电子显微镜(SEM)、振动样品磁强器(VSM)等仪器对产物进行表征,考察了复合材料的结构和磁性能。结果表明:通过优化条件,可以成功制备不同比例的... 以乙醇为溶剂,利用液相还原法制备不同比例的钴镍复合纳米颗粒,通过X射线衍射仪(XRD)、扫描电子显微镜(SEM)、振动样品磁强器(VSM)等仪器对产物进行表征,考察了复合材料的结构和磁性能。结果表明:通过优化条件,可以成功制备不同比例的钴镍复合纳米晶,该纳米晶的磁性随着钴含量的增加呈现规律性的变化,该材料有望成为一种新型的磁性材料和微波吸收材料。 展开更多
关键词 液相还原 钴镍复合 纳米颗粒 磁性能
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环氧树脂基体的原位增韧技术研究进展 预览
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作者 魏波 周金堂 +2 位作者 姚正军 钱逸 钱崑 《材料导报》 EI CAS CSCD 北大核心 2019年第17期2976-2988,共13页
自20世纪初环氧树脂问世以来,其优异的胶黏性能、可加工性能、耐化学腐蚀性能等特性使环氧树脂被广泛应用于涂料、包装、电子产品的制造和封装等众多行业。近年来,环氧树脂优良的热稳定性、电绝缘性和物理、力学性能,使其作为复合材料... 自20世纪初环氧树脂问世以来,其优异的胶黏性能、可加工性能、耐化学腐蚀性能等特性使环氧树脂被广泛应用于涂料、包装、电子产品的制造和封装等众多行业。近年来,环氧树脂优良的热稳定性、电绝缘性和物理、力学性能,使其作为复合材料的浸润基体在航空航天、武器装备等众多国家前沿技术领域发挥了重要的作用。采用不同新型树脂模塑传递技术对以环氧树脂为基体的复合材料进行制备与加工,得到的产品具有收缩率小、整体性均一、耐腐蚀性能优良的优点,同时可以兼顾材料对电气性能和力学性能的要求。迄今,环氧树脂在航空工业仍处于主导地位。随着世界各国航空前沿技术的竞争愈演愈烈,对航空复合材料的发展提出了更高的要求,与航空航天相关的先进复合材料制备技术也在不断丰富和完善。环氧树脂在固化时形成的三维网状立体结构,一方面显著提高了材料的物理强度、硬度,但另一方面,这种结构的形成往往伴随着过高的交联密度,进而导致材料质脆、易裂,在某些极端环境下易发生脆性断裂,限制了环氧树脂的应用和发展。因此,对环氧树脂进行增韧处理,提高最终制品的冲击强度,拓宽其应用领域,一直是航空复合材料领域的研究重点。经过多年对环氧树脂增韧改性的尝试,研究者们已取得了丰硕的成果,各种增韧方案和增韧机理的相继建立大幅拓展了环氧树脂的应用范围。目前,国内外较为成熟的对环氧树脂进行增韧的方案大多属于原位增韧的范畴,即通过在原有均匀分散的环氧树脂多相体系中引入增强相或形成一种新相,保持浸润基体内部不同相的均匀空间分布状态,最终达到对环氧树脂制品增韧的目的。其中增韧效果优异的方案主要有:(1)在环氧树脂基体中引入橡胶粒子,或是添加热致液晶聚合物、超支化聚合物、核壳结构聚� 展开更多
关键词 环氧树脂 增韧 热致液晶 互穿网络聚合物 纳米粒子
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Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration
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作者 Gregory P. Howard Garima Verma +6 位作者 Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第4期837-844,共8页
Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presen... Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective "size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. 展开更多
关键词 BIODEGRADABLE nano particle LYMPH node TRAFFICKING VACCINE delivery NANOPARTICLE size an tigen PRESENTING cells in vivo imaging
两性离子聚合物链长对纳米粒穿黏液及细胞摄取能力的影响
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作者 郭权 郑雅娴 +3 位作者 吴蕾 周锐 刘晨冬 黄园 《药学学报》 CAS CSCD 北大核心 2019年第3期547-554,共8页
本研究旨在构建不同链长的聚磺酸甜菜碱甲基丙烯酸酯[poly(sulfobetaine methacrylate), pSBMA]修饰的纳米粒(pSBMAn NPs),以探究两性离子聚合物链长对纳米粒穿黏液及细胞摄取能力的影响。结合己内酯的开环聚合反应和原子转移自由基聚... 本研究旨在构建不同链长的聚磺酸甜菜碱甲基丙烯酸酯[poly(sulfobetaine methacrylate), pSBMA]修饰的纳米粒(pSBMAn NPs),以探究两性离子聚合物链长对纳米粒穿黏液及细胞摄取能力的影响。结合己内酯的开环聚合反应和原子转移自由基聚合反应(atom transfer radical polymerization, ATRP)合成不同链长的两嵌段聚合物--聚己内酯-聚磺酸甜菜碱甲基丙烯酸酯共聚物[poly(ε-caprolactone)-block-poly(sulfobetaine methacrylate), PCLpSBMA],并通过纳米沉淀法制备相应的纳米粒。采用黏蛋白吸附实验和Transwel小室实验考察纳米粒的穿黏液能力。以人源结肠癌Caco-2细胞和可分泌黏液的HT-MTX-E12细胞为模型,考察链长对纳米粒摄取及穿黏液能力的影响。研究结果表明:制得的pSBMAn NPs粒径相近,均约为100 nm,电位约为-7 mV。短链pSBMA修饰的纳米粒(pSBMA10NPs)的表观渗透系数(apparent permeability coefficient, Papp)仅是长链pSBMA纳米粒(pSBMA80NPs)的42.83%,但细胞摄取是pSBMA80NPs的2.44倍。有黏液存在时, pSBMAn NPs的摄取均降低,但pSBMA10NPs的细胞摄取能力仍最强。体内实验结果表明, pSBMA20NPs的口服生物利用度高于pSBMA10NPs (动物实验根据四川大学关于实验动物的饲养和使用准则进行,并得到四川大学实验动物伦理委员会批准)。本文为两性离子纳米粒的口服研究提供了参考。 展开更多
关键词 两性离子 链长 纳米粒 黏液 摄取
Mixed-phase Mesoporous TiO2 Film for High Efficiency Perovskite Solar Cells
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作者 XIANG Yan ZHUANG Jia +5 位作者 MA Zhu LU Honglin XIA Haoran ZHOU Weiya ZHANG Tao LI Haimin 《高等学校化学研究:英文版》 SCIE CAS CSCD 2019年第1期101-108,共8页
Mesoporous scaffold structures have played great roles in halide perovskite solar cells(PSCs),due to the excellent photovoltaic performance and commercial perspective of mesoporous PSCs.Here,we reported a mixed-phase ... Mesoporous scaffold structures have played great roles in halide perovskite solar cells(PSCs),due to the excellent photovoltaic performance and commercial perspective of mesoporous PSCs.Here,we reported a mixed-phase TiO2 mesoporous film as an efficient electron transport layer(ETL)for mesoporous perovskite solar cells.Due to the improved crystal phase,fihn thickness and nanopartMe size of TiO2 layer,which were controlled by varying the one-step hydrothermal reaction time and annealing time,the PSCs exhibited an outstanding short circuit photocurrent density of 25.27 mA/cm^2,and a maximum power conversion efficiency(PCE)of 19.87%.It is found that the ultra-high Jsc attributes to the excellent film quality,light capturing and excellent electron transport ability of mixed-phase TiO2 mesoporous film.The results indicate that mix-phase mesoporous metal oxide fihns could be a promising candidate for producing effective ETLs and high efficiency PSCs. 展开更多
关键词 MESOPOROUS PEROVSKITE solar cell MIXED-PHASE TiO2 HYDROTHERMAL method NANOPARTICLE Electron re- combination
Experimental investigation of enhancement of carbon dioxide foam stability, pore plugging, and oil recovery in the presence of silica nanoparticles
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作者 Abdul Rahim Risal Muhammad A. Manan +3 位作者 Nurudeen Yekeen Nur Bashirah Azli Ali Mohamed Samin Xin Kun Tan 《石油科学:英文版》 SCIE CAS CSCD 2019年第2期344-356,共13页
The influence of surface-modified silica(SiO2) nanoparticles on the stability and pore plugging properties of foams in porous media was investigated in this study. The pore plugging ability of foams was estimated from... The influence of surface-modified silica(SiO2) nanoparticles on the stability and pore plugging properties of foams in porous media was investigated in this study. The pore plugging ability of foams was estimated from the pressure drop induced during foam propagation in porous media. The results clearly showed that the modified Si02 nanoparticlestabilized foam exhibited high stability, and the differential pressure increased in porous media by as much as three times.The addition of SiO2 nanoparticles to the foaming dispersions further mitigated the adverse effect of oil toward the foam pore plugging ability. Consequently, the oil recovery increased in the presence of nanoparticles by approximately 15%during the enhanced oil recovery experiment. The study suggested that the addition of surface-modified silica nanoparticles to the surfactant solution could considerably improve the conventional foam stability and pore plugging performance in porous media. 展开更多
关键词 Foam PORE plugging Surface-modified NANOPARTICLE Enhanced oil RECOVERY
Au@SiO2@CuInS2–ZnS/Anti-AFP fluorescent probe improves HCC cell labeling 预览
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作者 Yi-Wen Dai Li-Xin Zhu +5 位作者 Yan Zhang Shu-Hui Wang Kui Chen Tong-Tong Jiang Xiao-Liang Xu Xiao-Ping Geng 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2019年第3期266-272,共7页
Background: Clear tumor imaging is essential to the resection of hepatocellular carcinoma(HCC). This study aimed to create a novel biological probe to improve the HCC imaging. Methods: Au nano-flower particles and CuI... Background: Clear tumor imaging is essential to the resection of hepatocellular carcinoma(HCC). This study aimed to create a novel biological probe to improve the HCC imaging. Methods: Au nano-flower particles and CuInS2 –Zn S core-shell quantum dots were synthesized by hydrothermal method. Au was coated with porous SiO2 and combined with anti-AFP antibody. HCC cell line HepG2 was used to evaluate the targeting efficacy of the probe, while flow cytometry and MTT assay were used to detect the cytotoxicity and bio-compatibility of the probe. Probes were subcutaneously injected to nude mice to explore light intensity and tissue penetration. Results: The fluorescence stability of the probe was maintained 100% for 24 h, and the brightness value was 4 times stronger than that of the corresponding CuInS2 –Zn S quantum dot. In the targeting experiment, the labeled HepG2 emitted yellow fluorescence. In the cytotoxicity experiments, MTT and flow cytometry results showed that the bio-compatibility of the probe was fine, the inhibition rate of HepG2 cell with 60% Cu-QDs/Anti-AFP probe and Au-QDs/Anti-AFP probe solution for 48 h were significantly different(86.3%±7.0% vs. 4.9%±1.3%, t = 19.745, P < 0.05), and the apoptosis rates were 83.3%±5.1% vs. 4.4%±0.8%( P < 0.001). In the animal experiment, the luminescence of the novel probe can penetrate the abdominal tissues of a mouse, stronger than that of CuInS2 –ZnS quantum dot. Conclusions: The Au@SiO2 @CuInS2 –ZnS/Anti-AFP probe can targetedly recognize and label HepG2 cells with good bio-compatibility and no toxicity, and the strong tissue penetrability of luminescence may be helpful to surgeons. 展开更多
关键词 PLASMON enhancement Quantum DOTS NANOPARTICLE LUMINESCENCE CYTOTOXICITY
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