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Management of betablocked patients after sustained virological response in hepatitis C cirrhosis 预览
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作者 Marta Abadía María Luisa Montes +6 位作者 Dolores Ponce Consuelo Froilán Miriam Romero Joaquín Poza Teresa Hernández Rubén Fernández-Martos Antonio Olveira 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第21期2665-2674,共10页
BACKGROUND Current guidelines do not address the post–sustained virological response management of patients with baseline hepatitis C virus (HCV) cirrhosis and oesophageal varices taking betablockers as primary or se... BACKGROUND Current guidelines do not address the post–sustained virological response management of patients with baseline hepatitis C virus (HCV) cirrhosis and oesophageal varices taking betablockers as primary or secondary prophylaxis of variceal bleeding. We hypothesized that in some of these patients portal hypertension drops below the bleeding threshold after sustained virological response, making definitive discontinuation of the betablockers a safe option. AIM To assess the evolution of portal hypertension, associated factors, non-invasive assessment, and risk of stopping betablockers in this population. METHODS Inclusion criteria were age > 18 years, HCV cirrhosis (diagnosed by liver biopsy or transient elastography > 14 kPa), sustained virological response after directacting antivirals, and baseline oesophageal varices under stable, long-term treatment with betablockers as primary or secondary bleeding prophylaxis. Main exclusion criteria were prehepatic portal hypertension, isolated gastric varices, and concomitant liver disease. Blood tests, transient elastography, and upper gastrointestinal endoscopy were performed. Hepatic venous pressure gradient (HVPG) was measured five days after stopping betablockers. Betablockers could be stopped permanently if gradient was < 12 mmHg, at the discretion of the attending physician. RESULTS Sample comprised 33 patients under treatment with propranolol or carvedilol: median age 64 years, men 54.5%, median Model for End-Stage Liver Disease (MELD) score 9, Child-Pugh score A 77%, median platelets 77.000 × 103/μL, median albumin 3.9 g/dL, median baseline transient elastography 24.8 kPa, 88% of patients received primary prophylaxis. Median time from end of antivirals to gradient was 67 wk. Venous pressure gradient was < 12 mmHg in 13 patients (39.4%). In univariate analysis the only associated factor was a MELD score decrease from baseline. On endoscopy, variceal size regressed in 19/27 patients (70%), although gradient was ≥ 12 mmHg in 12/19 patients. The elastogr 展开更多
关键词 Hepatitis C virus OESOPHAGEAL VARICES PORTAL HYPERTENSION Betablocker Variceal BLEEDING
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Histopathological changes in the oesophageal mucosa in Egyptian children with corrosive strictures:A single-centre vast experience 预览
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作者 Ayman Eskander Carolyne Ghobrial +4 位作者 Nabil A Mohsen Bahaa Mounir Dalia Abd EL-Kareem Sara Tarek Mortada HF El-Shabrawi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第7期870-879,共10页
BACKGROUND The caustic ingestion continues to be a major problem worldwide especially in developing countries.The long-term complications include stricture and increased life time risk of oesophageal carcinoma.Patient... BACKGROUND The caustic ingestion continues to be a major problem worldwide especially in developing countries.The long-term complications include stricture and increased life time risk of oesophageal carcinoma.Patients suffered from corrosive induced oesophageal strictures have more than a 1000-fold risk of developing carcinoma of the oesophagus.AIM To determine the possibility of oesophageal mucosal dysplasia after prolonged dilatation in post corrosive stricture.METHODS This observational study was conducted at the Paediatric Endoscopy Unit in Cairo University Children’s Hospital.It included children of both sexes older than 2 years of age who had an established diagnosis of post-corrosive oesophageal stricture and repeated endoscopic dilatation sessions for more than 6 mo.All patients were biopsied at the stricture site after 6 mo of endoscopic dilatation.A histopathological examination of an oesophageal mucosal biopsy was performed for the detection of chronic oesophagitis,inflammatory cellular infiltration and dysplasia.RESULTS The mean age of the enrolled children was 5.9±2.6 years;90%of the patients had ingested an alkaline corrosive substance(potash).The total number of endoscopic dilatation sessions were ranging from 16 to 100 with mean number of sessions was 37.2±14.9.Histopathological examination of the specimens showed that 85%of patients had evidence of chronic oesophagitis(group A)in the form of basal cell hyperplasia,hyperkeratosis and subepithelial fibrosis.Thirteen percent of the patients had evidence of reactive atypia(group B)in the form of severe neutrophilic intraepithelial inflammatory cellular infiltration,and 2 patients(2%)had mild squamous dysplasia(group C);we rebiopsied these two patients 6 mo after the initial pathological assessment,guided by chromoendoscopy by Lugol's iodine.CONCLUSION The histopathology of oesophageal mucosal biopsies in post-corrosive patients demonstrates evidence of chronic oesophagitis,intraepithelial inflammatory cellular infiltration and dysplasia.Dysplasi 展开更多
关键词 CHILDREN Endoscopic DILATATION DYSPLASIA OESOPHAGEAL STRICTURES Postcorrosive
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Update on management of gastric varices 预览
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作者 Louisa J Vine Mohsan Subhani Juan G Acevedo 《世界肝病学杂志:英文版(电子版)》 2019年第3期250-260,共11页
Gastric varices (GV) have different physiology and clinical characteristics compared to oesophageal varices (OV). There is little information about the management of GV. Most part of the recommendations is extrapolate... Gastric varices (GV) have different physiology and clinical characteristics compared to oesophageal varices (OV). There is little information about the management of GV. Most part of the recommendations is extrapolated from studies where the majority of participants had OV. Thus, most recommendations lack of strong evidence. This is a comprehensive review on all aspects of management of GV, i.e., primary, secondary prophylaxis and management of acute bleeding. The papers on which international societies' recommendations are based are scrutinised in this review and areas of research are identified. 展开更多
关键词 Gastric VARICES OESOPHAGEAL VARICES PORTAL HYPERTENSION CIRRHOSIS
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Porphyromonas gingivalis and digestive system cancers 预览
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作者 Ying Zhou Guang-Hua Luo 《世界临床病例杂志》 2019年第7期819-829,共11页
Porphyromonas gingivalis (P. gingivalis) is an anaerobic gram-negative bacterium that colonizes in the epithelium and has been strongly associated with periodontal disease. Recently, various degrees of associations be... Porphyromonas gingivalis (P. gingivalis) is an anaerobic gram-negative bacterium that colonizes in the epithelium and has been strongly associated with periodontal disease. Recently, various degrees of associations between P. gingivalis and digestive system cancers, including oral squamous cell carcinoma in the oral cavity, oesophageal squamous carcinoma in the digestive tract, and pancreatic cancer in pancreatic tissues, have been displayed in multiple clinical and experimental studies. Since P. gingivalis has a strong association with periodontal diseases, not only the relationships between P. gingivalis and digestive system tumours but also the effects induced by periodontal diseases on cancers are well-illustrated in this review. In addition, the prevention and possible treatments for these digestive system tumours induced by P. gingivalis infection are also included in this review. At the end, we also highlighted the possible mechanisms of cancers caused by P. gingivalis. One important carcinogenic effect of P. gingivalis is inhibiting the apoptosis of epithelial cells, which also plays an intrinsic role in protecting cancerous cells. Some signalling pathways activated by P. gingivalis are involved in cell apoptosis, tumourigenesis, immune evasion and cell invasion of tumour cells. In addition, metabolism of potentially carcinogenic substances caused by P. gingivalis is also one of the connections between this bacterium and cancers. 展开更多
关键词 PORPHYROMONAS gingivalis Oral SQUAMOUS CELL CARCINOMA OESOPHAGEAL SQUAMOUS CELL CARCINOMA Pancreatic cancer PERIODONTAL diseases
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Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre 预览
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作者 Chris Harrington Lyn Smith +4 位作者 Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley 《世界胃肠内镜杂志:英文版(电子版)》 2018年第1期37-44,共8页
AIM To investigate the impact of endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA)and positron emission tomography-computed tomography(PETCT)in the nodal staging of upper gastrointestinal(GI)cancer in a tert... AIM To investigate the impact of endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA)and positron emission tomography-computed tomography(PETCT)in the nodal staging of upper gastrointestinal(GI)cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015.Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included.Using a positive EUS-FNA result as the gold standard for lymph node involvement,the sensitivity,specificity,positive and negative predictive values(PPV and NPV)and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated.The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included.Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional),forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma.The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases,therefore thirteen patients(10.7%)were excluded from further analysis.There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%).The sensitivity,specificity,PPV and NPV values of PET-CT were 92.5%,50%,52.1%and 91.9%respectively.There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%).MDT discussion led to a radical treatment pathway in twenty seven of these cases,after the final tumour stage was altered as a direct consequence of the EUS-FNA findings.Of these patients,fourteen(51.9%)experienced clinical remission of a median of nine months(range three to forty two months).CONCLUSION EUS-FNA leads to altered staging of upper GI cancer,resulting in more patients receiving radical treatment t 展开更多
关键词 Endoscopic ultrasound Oesophago-gastric CANCER STAGING OESOPHAGEAL CANCER POSITRON emission tomography-computed TOMOGRAPHY MEDIASTINAL nodes
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Construction of an oesophageal cancer-specific ceRNA network based on miRNA,lncRNA,and mRNA expression data 预览
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作者 Wen-Hua Xue Zhi-Rui Fan +4 位作者 Li-Feng Li Jing-Li Lu Bing-Jun Ma Quan-Cheng Kan Jie Zhao 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第1期23-34,共12页
AIM To explore the expression profiles of microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and mRNAs in oesophageal squamous cell carcinoma(ESCC)in order to construct an oesophageal cancer-specific competing endogenous... AIM To explore the expression profiles of microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and mRNAs in oesophageal squamous cell carcinoma(ESCC)in order to construct an oesophageal cancer-specific competing endogenous RNA(ceRNA)network.METHODS In this work,the expression data of miRNAs,lncRNAs,and mRNAs in ESCC were obtained.An oesophageal cancer-specific ceRNA network was then constructed and investigated.RESULTS CeRNAs have the ability to reduce the targeting activity mRNAs with common miRNA response elements.CeRNA interactions have a critical effect in gene regulation and cancer development.CONCLUSION This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers. 展开更多
关键词 Competing ENDOGENOUS RNA MicroRNA Long NON-CODING RNA MRNA OESOPHAGEAL SQUAMOUS cell carcinoma
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Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma:A retrospective single centre experience 预览
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作者 David Graham Nejc Sever +11 位作者 Cormac Magee William Waddingham Matthew Banks Rami Sweis Hannah Al-Yousuf Miriam Mitchison Durayd Alzoubaidi Manuel Rodriguez-Justo Laurence Lovat Marco Novelli Marnix Jansen Rehan Haidry 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第41期4698-4707,共10页
AIM To assess clinical outcomes for submucosal(T1b)oesophageal adenocarcinoma(OAC)patients managed with either surgery or endoscopic eradication therapy.METHODS Patients found to have T1b OAC following endoscopic rese... AIM To assess clinical outcomes for submucosal(T1b)oesophageal adenocarcinoma(OAC)patients managed with either surgery or endoscopic eradication therapy.METHODS Patients found to have T1b OAC following endoscopic resection between January 2008 to February 2016 at University College London Hospital were retrospectively analysed.Patients were split into low-risk and high-risk groups according to established histopathological criteria and were then further categorised according to whether they underwent surgical resection or conservative management.Study outcomes include the presence of lymphnode metastases,disease-specific mortality and overall survival.RESULTS A total of 60 patients were included;22 patients were surgically managed(1 low-risk and 21 high-risk patients)whilst 38 patients were treated conservatively(12 low-risk and 26 high-risk).Overall,lymph node metastases(LNM)were detected in 10 patients(17%);six of these patients had undergone conservative management and LNM were detected at a median of 4 mo after endoscopic mucosal resection(EMR).All LNM occurred in patients with highrisk lesions and this represented 21%of the total high-risk lesions.Importantly,there was no statistically significant difference in tumor-related deaths between those treated surgically or conservatively(P=0.636)and disease-specific survival time was also comparable between the two treatment strategies(P=0.376).CONCLUSION T1b tumours without histopathological high-risk markers of LNM can be treated endoscopically with good outcomes.In selected patients,endoscopic therapy may be appropriate for high-risk lesions. 展开更多
关键词 OESOPHAGEAL ADENOCARCINOMA SUBMUCOSAL invasion T1b LYMPH node metastasis RISK prediction Endoscopy
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Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test? 预览 被引量:1
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作者 GregoryLFalk JohnBeattie +4 位作者 AlvinIng SEFalk MichaelMagee LeticiaBurton HansVanderWall 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第12期3619-3627,共9页
AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms tha... AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease. 展开更多
关键词 Laryngopharyngeal REFLUX P H STUDIES OESOPHAGEAL m
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Treatment of dysplastic Barrett's Oesophagus in lowervolume centres after structured training 预览
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作者 Georgina Chadwick Jack Faulkner Robert Ley-Greaves Panagiotis Vlavianos Rob Goldin Jonathan Hoare 《世界胃肠内镜杂志:英文版(电子版)》 2015年第1期66-72,共7页
AIM: To investigate whether dysplastic Barrett'sOesophagus can be safely and effectively treatedendoscopically in low volume centres after structuredtraining.METHODS: After attending a structured trainingprogram in... AIM: To investigate whether dysplastic Barrett'sOesophagus can be safely and effectively treatedendoscopically in low volume centres after structuredtraining.METHODS: After attending a structured trainingprogram in Amsterdam on the endoscopic treatmentof dysplastic Barrett's Oesophagus, treatment ofthese patients was initiated at St Marys Hospital. Thisis a retrospective case series conducted at a UnitedKingdom teaching Hospital, of patients referred forendoscopic treatment of Barrett's oesophagus with highgrade dysplasia or early cancer, who were diagnosedbetween January 2008 and February 2012. Datawas collected on treatment provided (radiofrequencyablation and endoscopic resection), and success oftreatment both at the end of treatment and at followup. Rates of immediate and long term complicationswere assessed.RESULTS: Thirty-two patients were referred to StMarys with high grade dysplasia or intramucosal cancerwithin a segment of Barrett's Oesophagus. Twentysevenmet the study inclusion criteria, 16 of these hada visible nodule at initial endoscopy. Treatment wasgiven over a median of 5 mo, and patients receiveda median of 3 treatment sessions over this time.At the end of treatment dysplasia was successfullyeradicated in 96% and intestinal metaplasia in 88%, onper protocol analysis. Patients were followed up for amedian of 18 mo. At which time complete eradicationof dysplasia was maintained in 86%. Complicationswere rare: 2 patients suffered from post-procedural bleeding, 4 cases were complicated by oesophageal stenosis. Recurrence of cancer was seen in 1 case. CONCLUSION: With structured training good outcomes can be achieved in low volume centres treating dysplastic Barrett's Oesophagus. 展开更多
关键词 Barrett's OESOPHAGUS OESOPHAGEAL cancer ENDOSCOPIC TREATMENT Radiofrequency ablation ENDOSCOPIC resection
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Capsule endoscopy:Current practice and future directions 预览
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作者 Melissa F Hale Reena Sidhu Mark E McAlindon 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第24期7752-7759,共8页
Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel... Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. 展开更多
关键词 CAPSULE ENDOSCOPY SMALL BOWEL INDICATIONS Technolo
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MiR-210 expression reverses radioresistance of stem-like cells of oesophageal squamous cell carcinoma 预览
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作者 Xin Chen Jia Guo +3 位作者 Ru-Xing Xi Yu-Wei Chang Fei-Yang Pan Xiao-Zhi Zhang 《世界临床肿瘤学杂志》 2014年第5期1068-1077,共10页
AIM:To investigate the expression of miR-210 and the role it plays in the cell cycle to regulate radioresistance in oesophageal squamous cell carcinoma(ESCC).METHODS:MiR-210 expression was evaluated in 37 pairs of ESC... AIM:To investigate the expression of miR-210 and the role it plays in the cell cycle to regulate radioresistance in oesophageal squamous cell carcinoma(ESCC).METHODS:MiR-210 expression was evaluated in 37 pairs of ESCC tissues and matched para-tumorous normal oesophageal tissues from surgical patients who had not received neoadjuvant therapy,and in the cells of two novel radioresistant cell lines,TE-1R and Eca-109R,using quantitative reverse transcription-polymerase chain reaction(qRT-PCR).The transient up-regulation of miR-210 expression in TE-1R and Eca-109R cells was studied using liposomes and was confirmed using qRT-PCR.The rate of cell survival after a series of radio-treatment doses was evaluated using the clone formation assay.Flow cytometry was used to detect the changes to the cell cycle patterns due to radiation treatment.RT-PCR and Western blot were used to detect the expression of ataxia telangiectasia mutated(ATM)and DNA dependent protein kinase(DNA-PKcs)after irradiation,and the cell sphere formation assay was used to evaluate the proliferative ability of the cancer stem-like cells.RESULTS:The level of miR-210 expression was significantly decreased,by 21.3%to 97.2%,with the average being 39.2%±16.1%,in the ESCC tissues of most patients(81.1%,30 of 37 vs patients with high miR-210 expression,P<0.05).A low level of expression of miR-210 was correlated with a poorly differentiated pathological type(P<0.01)but was not correlated with the T-stage or lymph node infiltration(both P>0.05).Early local recurrences(<18 mo,n=19)after radiotherapy were significantly related with low miR-210 expression(n=13,P<0.05).The level of miR-210 was decreased by approximately 73%(vs TE-1,0.27±0.10,P<0.01)in the established radioresistant TE-IR cell line and by 52%(vs Eca-109,0.48±0.17,P<0.05)in the corresponding Eca-109R line.Transient transfection with a miR-210 precursor increased the level of miR-210 expression,leading to a significant increase in cell survival after radiotherapy(P<0.05).Twenty-four hours after radi 展开更多
关键词 MIR-210 OESOPHAGEAL squamous CELL carcinoma Radiation resistance CELL cycle arrest Stem-like CELLS
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Cdx2与食管炎、Barrett’s食管及腺癌的关系 被引量:2
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作者 刘仕琪 吕毅 《国际外科学杂志》 2012年第5期 342-346,共5页
同源异型盒转录因子2是新发现的尾相关同源异型盒转录因子家族中的一个成员,特异地表达于从十二指肠至肛管齿状线的肠道绒毛上皮,在其他空腔脏器黏膜上皮异位表达时可诱导相应部位的肠化生或腺癌发生。在胃十二指肠反流-食管炎一Barr... 同源异型盒转录因子2是新发现的尾相关同源异型盒转录因子家族中的一个成员,特异地表达于从十二指肠至肛管齿状线的肠道绒毛上皮,在其他空腔脏器黏膜上皮异位表达时可诱导相应部位的肠化生或腺癌发生。在胃十二指肠反流-食管炎一Barrett’s食管一食管腺癌演化过程中,同源异型盒转录因子2起着重要的调控作用,并与p63基因、维甲酸、MUC2、骨形态发生蛋白4等多因素共同作用促进了这一过程的发展。 展开更多
关键词 食管 炎症 肠化生 肿瘤 同源异型盒转录因子2
Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? 预览 被引量:1
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作者 Theodore D Tsirlis George Papastratis +4 位作者 Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2008年第17期2691-2701,共11页
转移是癌症死亡的主要原因,与是的淋巴系统肿瘤传播的第一条线路。glycoproteins VEGF-C 和 VEGF-D 是家庭,其角色是最近在胚胎开始期间并且在象发炎,淋巴系统混乱和恶性瘤转移那样的病变作为淋巴系统管理者认出了的脉管的内皮生长因... 转移是癌症死亡的主要原因,与是的淋巴系统肿瘤传播的第一条线路。glycoproteins VEGF-C 和 VEGF-D 是家庭,其角色是最近在胚胎开始期间并且在象发炎,淋巴系统混乱和恶性瘤转移那样的病变作为淋巴系统管理者认出了的脉管的内皮生长因素(VEGF ) 的成员。他们是为淋巴的内皮房间的膜上的 VEGFR-3 受体的 ligands,导致存在淋巴管的膨胀以及在新的(lymphangiogenesis ) 的植被。他们的决心在由免疫吸收并且在由免疫组织化学和反向的抄写聚合酶链反应(RT-PCR ) 的织物标本的传播的血是可行的。试验性并且 clinicopathological 研究连接了 VEGF-C, VEGF-D/VEGFR3 轴到淋巴的传播以及到在几个人的稳固的肿瘤的临床的结果。这些数据的多数从外科的标本和恶意的房间系列被导出,使他们的临床的申请变为可疑,由于主观因素和处理以后的数量化离子。以克服这些缺点,这些分子的传播层次的免疫察觉的一个其他的方法在研究被使用了在上胃,食道并且渲染表面的癌症。他们的结果表示 VEGF-C 的那个数量化离子,在血样品的 VEGF-D 能作为淋巴节点转移服务预兆的简历标记并且贡献胃肠的恶意的外科手术前的阶段。 展开更多
关键词 VEGF-C VEGF-D 胃肠疾病 结直肠癌 淋巴结转移
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Digestive Tract
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《中国医学文摘:内科学分册(英文版)》 2007年第3期160-167,共8页
9.1 Esophagus2007343 Overlapping between gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome.
关键词 DYSPEPSIA IRRITABLE colorectal gastritis EROSIVE NODULAR mucosa pressor OESOPHAGEAL ESOPHAGITIS
GENERAL DIAGNOSIS
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《中国医学文摘:内科学分册(英文版)》 2006年第2期65-66,共2页
2006133 Value of 18F-FDG dual-head coincidence imaging in the diagnosis of recurrent and metastatic oesophageal carcinoma. ZHANG Chun (张春), et al. Dept Nucl Med,Beijing Chaoyang Hosp,Capital Med Sci Univ,Beijing 10... 2006133 Value of 18F-FDG dual-head coincidence imaging in the diagnosis of recurrent and metastatic oesophageal carcinoma. ZHANG Chun (张春), et al. Dept Nucl Med,Beijing Chaoyang Hosp,Capital Med Sci Univ,Beijing 100020. Chin J Nucl Med 2006;26(1):34-36. Objective:To explore the value of 18 F-fluorodeoxyglu-cose (FDG) dual-head coinci dence imaging in the diagnosis of recurrent and metastatic oesophageal carcinoma. 展开更多
关键词 metastatic OESOPHAGEAL COINCIDENCE MODALITY METASTASES hundred metastasis HILAR USEFULNESS postoperative
明显威胁婴幼儿生命事件的病因:系统性回顾 预览
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作者 McGovern M. C. Smith M. B. H. 王一飞 《世界核心医学期刊文摘:儿科学分册》 2005年第4期26-27,共2页
【正】目的:探讨当婴幼儿第一次出现明显威胁生命事件(ALTE)时最可能的诊断。方法:笔者检索了1966-2002年Medline、1980-2002年Embase以及1982-2002年Cinahl数据库的资料。为了进一步研究,笔者与有关专家进行联系。搜集了各种研究、回... 【正】目的:探讨当婴幼儿第一次出现明显威胁生命事件(ALTE)时最可能的诊断。方法:笔者检索了1966-2002年Medline、1980-2002年Embase以及1982-2002年Cinahl数据库的资料。为了进一步研究,笔者与有关专家进行联系。搜集了各种研究、回顾性文章和书籍。对外文研究进行翻译。如果文章对ALTE给出明确 展开更多
关键词 系统性回顾 ALTE OESOPHAGEAL 胃食管返流 单病种 gastro noted LIKELY 下呼吸道感染 APPARENT
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Tuberculous Mediastinal Lymphadenitis Masquerading as Leiomyoma of the Oesophagus:A Report of Four Cases 预览
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作者 杭俊德 陈炽贤 +3 位作者 王长龙 苏惠群 苏守元 尹兴家 《中国医科大学学报》 CAS CSCD 1989年第S2期14-19,共6页
Four Patients with tuberculous mediastinal lymphadenitis resembling leiomyoma of the oesophagus are presented. The differential diagnosis between this disease and leiomyoma of the oesophagus is discussed. In any adu... Four Patients with tuberculous mediastinal lymphadenitis resembling leiomyoma of the oesophagus are presented. The differential diagnosis between this disease and leiomyoma of the oesophagus is discussed. In any adult patient, especially young females with dysphagia and filling defects along the middle third of the oesophagus, the possibility of tuberculous mediastinal lymphadenitis should be considered in the differential diagnosis. The material here presented is based upon conventional radiologic methods which are also available in the developing countries. 展开更多
关键词 TUBERCULOUS possibility filling young tumour admitted OESOPHAGEAL invading likely margin
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THE DIET AS A RISK RACTOR IN THE ETIOLOGY OF OESOPHAGEAL CANCER IN CASPIAN LITTORAL. 预览
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作者 Abed-AliZia’ee Ferdous Rastgar Farzaneh Sabouni 《癌变.畸变.突变》 CAS CSCD 1991年第S1期268-268,共1页
Several risk factors have been nominated for theirsuspected roles in the etiology of oesophageal neopla-sia in north-east of Iran;Mazandaran Province,whichhas shown one of the highest incidence rate in theworld.Howe... Several risk factors have been nominated for theirsuspected roles in the etiology of oesophageal neopla-sia in north-east of Iran;Mazandaran Province,whichhas shown one of the highest incidence rate in theworld.However,the attention is mostly focused on therole of diet,The commonly consumed fish,meat,vege- 展开更多
关键词 OESOPHAGEAL consumed mostly ETIOLOGY incidence north EXTRACTS DNA DRINKING stored
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小潮气量机械通气下经外周动脉监测老年患者心输出量的准确性研究
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作者 赵磊 王天龙 +6 位作者 肖玮 范隆 刘清海 安奕 王萍 李丽霞 李中嘉 《北京医学》 CAS 2019年第2期122-125,共4页
目的探讨经外周动脉连续心输出量监测技术用于小潮气量机械通气老年患者腹腔镜结肠手术术中容量管理的准确性。方法选择2017年3~5月在首都医科大学宣武医院行择期腹腔镜结肠手术的老年患者18例,给予小潮气量机械通气,观察直腿抬高试验... 目的探讨经外周动脉连续心输出量监测技术用于小潮气量机械通气老年患者腹腔镜结肠手术术中容量管理的准确性。方法选择2017年3~5月在首都医科大学宣武医院行择期腹腔镜结肠手术的老年患者18例,给予小潮气量机械通气,观察直腿抬高试验和容量快速冲击试验前后,经外周动脉连续心输出量监测技术和经食道多普勒超声技术获得的每搏量(stroke volume, SV)和每搏量变异度(stroke volume variation, SVV),并进行比较。结果 Bland-Altman法分析两种方法获得的70对SV改变百分比数据,偏倚均值为-0.002%,偏倚标准差为1.73%,95%CI 3.389%~-3.393%,错误百分比为33.6%,但经外周动脉连续心输出量监测技术的SVV对于容量反应性预测不够准确。结论对于小潮气量正压机械通气下实施腹腔镜结肠手术的老年患者,经外周动脉连续心输出量监测技术获得的SV改变与经食道多普勒超声技术获得的SV改变准确度类似,但SVV对于该模式下患者容量反应性的预测能力还需大样本研究证实。 展开更多
关键词 经外周动脉连续心输出量监测 经食道多普勒超声 老年患者 容量反应性 每搏量变异度
三维重建技术在食管癌术前诊断的临床应用价值 预览
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作者 马晓超 王盈舒 +2 位作者 王瑞 刘桂华 崔有斌 《中国实验诊断学》 2019年第2期203-206,共4页
目的三维重建功能在临床上已被广泛应用于临床的术前诊断评估,但对于食管肿瘤术前评估的应用研究甚少。本研究旨在探讨三维重建技术在食管下段肿瘤患者术前诊断中的应用,以提高食管癌的诊断和治疗水平,为患者术前评估提供一种更精准、... 目的三维重建功能在临床上已被广泛应用于临床的术前诊断评估,但对于食管肿瘤术前评估的应用研究甚少。本研究旨在探讨三维重建技术在食管下段肿瘤患者术前诊断中的应用,以提高食管癌的诊断和治疗水平,为患者术前评估提供一种更精准、科学的方法。方法所有患者均于2014年1月至2015年8月在吉林大学第一医院接受食管癌治疗。本研究收集患者的影像资料,应用表面重建技术重建食管肿瘤及邻近结构。分析并计算肿瘤的形状和其他具体参数,并对不同条件下的三维重建结果进行比较。研究使用IBM SPSS 19对所有数据进行分析。所有数据均在3次测量中进行平均。采用t检验、方差分析比较组间差异,P<0.05被视为差异有统计学意义。结果本研究共纳入在72例患者,其中48例胃镜能够通过食道病变,24例不能通过。48例患者的病变部位在30cm-42cm之间。内镜测量长度和三维长度均大于病理长度(P<0.05),但内镜测量长度与三维长度无显著性差异。在CT阳性淋巴结重建数据中,阴性组淋巴结的长度、直径、体积、CT值和重建与阳性组比较有显著性差异。结论三维重建在食管癌术前诊断的应用是安全有效的。三维重建在肿瘤及周围淋巴结的术前评估中起着重要作用,可用于食管癌放疗和化疗远期疗效的评价。 展开更多
关键词 食管癌 三维重建 诊断与治疗
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