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Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis 预览
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作者 Yu Liang Cheng Zhang Dong-Qiu Dai 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第26期3392-3407,共16页
BACKGROUND DNA methylation, acknowledged as a key modification in the field of epigenetics, regulates gene expression at the transcriptional level. Aberrant methylation in DNA regulatory regions could upregulate oncog... BACKGROUND DNA methylation, acknowledged as a key modification in the field of epigenetics, regulates gene expression at the transcriptional level. Aberrant methylation in DNA regulatory regions could upregulate oncogenes and downregulate tumor suppressor genes without changing the sequences.However, studies of methylation in the control of gene expression are still inadequate. In the present research, we performed bioinformatics analysis to clarify the function of methylation and supply candidate methylation-related biomarkers and drivers for colon cancer.AIM To identify and analyze methylation-regulated differentially expressed genes(MeDEGs) in colon cancer by bioinformatics analysis.METHODS We downloaded RNA expression profiles, Illumina Human Methylation 450 K BeadChip data, and clinical data of colon cancer from The Cancer Genome Atlas project. MeDEGs were identified by analyzing the gene expression and methylation levels using the edgeR and limma package in R software. Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses were performed in the DAVID database and KEGG Orthology-Based Annotation System 3.0, respectively. We then conducted Kaplan–Meier survival analysis to explore the relationship between methylation and expression and prognosis. Gene set enrichment analysis(GSEA) and investigation of protein-protein interactions(PPI) were performed to clarify the function of prognosis-related genes.RESULTS A total of 5 up-regulated and 81 down-regulated genes were identified asMeDEGs. GO and KEGG pathway analyses indicated that MeDEGs were enriched in multiple cancer-related terms. Furthermore, Kaplan–Meier survival analysis showed that the prognosis was negatively associated with the methylation status of glial cell-derived neurotrophic factor(GDNF) and reelin(RELN). In PPI networks, GDNF and RELN interact with neural cell adhesion molecule 1. Besides, GDNF can interact with GDNF family receptor alpha(GFRA1), GFRA2, GFRA3, and RET. RELN can interact with RAFAH1 B 展开更多
关键词 COLON CANCER BIOINFORMATICS analysis The CANCER Genome Atlas project DNA METHYLATION Methylation-regulated DIFFERENTIALLY expressed genes Overall survival
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Prediction of overall survival following colorectal cancer surgery in elderly patients 预览
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作者 Isaac Seow-En Winson Jianhong Tan +7 位作者 Sreemanee Raaj Dorajoo Sharon Hui Ling Soh Yi Chye Law Soo Yeun Park Gyu-Seok Choi Wah Siew Tan Choong Leong Tang Min Hoe Chew 《世界胃肠外科杂志:英文版(电子版)》 2019年第5期247-260,共14页
BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid condition.Justifying major surg... BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid condition.Justifying major surgery for these elderly patients can be challenging.An accurate tool demonstrating post-operative survival probability would be useful for surgeons and their patients.AIM To integrate clinically significant prognostic factors relevant to elective colorectal surgery in the elderly into a validated pre-operative scoring system.METHODS In this retrospective cohort study,patients aged 70 and above who underwent surgery for CRC at Singapore General Hospital between 1 January 2005 and 31 December 2012 were identified from a prospectively maintained database.Patients with evidence of metastatic disease,and those who underwent emergency surgery or had surgery for benign colorectal conditions were excluded from the analysis.The primary outcome was overall 3-year overall survival(OS)following surgery.A multivariate model predicting survival was derived and validated against an equivalent external surgical cohort from Kyungpook National University Chilgok Hospital,South Korea.Statistical analyses were performed using Stata/MP Version 15.1.RESULTS A total of 1267 patients were identified for analysis.The median post-operative length of stay was 8[interquartile range(IQR)6-12]d and median follow-up duration was 47(IQR 19-75)mo.Median OS was 78(IQR 65-85)mo.Following multivariate analysis,the factors significant for predicting overall mortality were serum albumin<35 g/dL,serum carcinoembryonic antigen≥20μg/L,T stage 3 or 4,moderate tumor cell differentiation or worse,mucinous histology,rectal tumors,and pre-existing chronic obstructive lung disease.Advanced age alone was not found to be significant.The Korean cohort consisted of 910 patients.The Singapore cohort exhibited a poorer OS,likely due to a higher proportion of advanced cancers.Despite the clinicopathologic differences,there was successful validation of 展开更多
关键词 COLORECTAL cancer surgery ELDERLY Overall SURVIVAL PRE-OPERATIVE PROGNOSTIC SCORE
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Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors 预览
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作者 Tsutomu Nishida Aya Sugimoto +11 位作者 Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第1期28-38,共11页
BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer (A-GC). AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in ... BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer (A-GC). AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC. METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage IV A-GC who underwent chemotherapy were enrolled. We defined the wait time (WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival (OS). RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin (Alb) levels and higher neutrophil/lymphocyte ratios and C-reactive protein (CRP) levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups (230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias, patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found (303 d vs 311 d, respectively, log-rank P = 0.9832). CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. 展开更多
关键词 Advanced gastric cancer WAITING TIME CHEMOTHERAPY PROGNOSIS Overall survival
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Hypofractionated particle beam therapy for hepatocellular carcinoma–a brief review of clinical effectiveness 预览
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作者 Che-Yu Hsu Chun-Wei Wang +1 位作者 Ann-Lii Cheng Sung-Hsin Kuo 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第8期579-588,共10页
Hepatocellular carcinoma(HCC)is the fifth most common malignancy and the second leading cause of cancer mortality worldwide.The cornerstone to improving the prognosis of HCC patients has been the control of loco-regio... Hepatocellular carcinoma(HCC)is the fifth most common malignancy and the second leading cause of cancer mortality worldwide.The cornerstone to improving the prognosis of HCC patients has been the control of loco-regional disease progression and the lesser toxicities of local treatment.Although radiotherapy has not been considered a preferred treatment modality for HCC,charged particle therapy(CPT),including proton beam therapy(PBT)and carbon ion radiotherapy(CIRT),possesses advantages(for example,it allows ablative radiation doses to be applied to tumors but simultaneously spares the normal liver parenchyma from radiation)and has emerged as an alternative treatment option for HCC.With the technological advancements in CPT,various radiation dosages of CPT have been used for HCC treatment via CPT.However,the efficacy and safety of the evolving dosages remain uncertain.To assess the association between locoregional control of HCC and the dose and regimen of CPT,we provide a brief overview of selected literature on dose regimens from conventional to hypofractionated short-course CPT in the treatment of HCC and the subsequent determinants of clinical outcomes.Overall,CPT provides a better local control rate compared with photon beam therapy,ranging from 80%to 96%,and a 3-year overall survival ranging from 50%to 75%,and it results in rare grade 3 toxicities of the late gastrointestinal tract(including radiation-induced liver disease).Regarding CPT for the treatment of locoregional HCC,conventional CPT is preferred to treat central tumors of HCC to avoid late toxicities of the biliary tract.In contrast,the hypo-fractionation regimen of CPT is suggested for treatment of larger-sized tumors of HCC to overcome potential radio-resistance. 展开更多
关键词 HEPATOCELLULAR carcinoma PROTON beam THERAPY Carbon ion RADIOTHERAPY Local control TOXICITY Overall survival
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Perioperative rh-endostatin with chemotherapy improves the survival of conventional osteosarcoma patients: a prospective non-randomized controlled study 预览
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作者 Hairong Xu Zhen Huang +3 位作者 Yuan Li Qing Zhang Lin Hao Xiaohui Niu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期166-172,共7页
Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the ... Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the probability of distant metastasis-free survival(DMFS) and overall survival(OS) in patients newly diagnosed with non-metastatic conventional osteosarcoma.Methods: This was a controlled non-randomized clinical study that included 388 patients without clinically detectable metastatic disease enrolled from January 2008 to April 2012. The control treatment group had 272 patients;180 were male and 92, female,with a median age of 17 years. The treatment group had 58 patients;36 were male and 22, female, with a median age of 16 years.The control group received preoperative chemotherapy followed by surgery and postoperative chemotherapy. The treatment group received 4 cycles of rh-endostatin perioperatively in addition to chemotherapy as per the control group. Patients were followed up from 6-101 months with a median follow-up period of 50.2 months.Results: The 5-year DMFS of the control group(61%) was significantly lower than that of the rh-endostatin group(79%)(P = 0.013). The 5-year OS of the control group(74%) was significantly lower than that of the rh-endostatin treatment group(87%)(P = 0.029). No difference in adverse drug reactions was found between these 2 groups.Conclusions: The addition of perioperative rh-endostatin to chemotherapy could significantly improve the DMFS and OS of patients with non-metastatic osteosarcoma. 展开更多
关键词 OSTEOSARCOMA rh-endostatin PERIOPERATIVE DISTANT metastasis overall SURVIVAL
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作为总体性的“美好生活”及其可能 预览
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作者 毛勒堂 韩涛 《吉首大学学报:社会科学版》 CSSCI 北大核心 2019年第3期13-19,共7页
新时代的“美好生活”叙事具有深刻的当代中国语境。“美好生活”是一个总体性范畴,既有丰富的理论内涵,又有现实的实践指向,同时具有高远的超越性向度。美好物质生活、美好政治生活、美好精神生活、美好社会生活、美好生态生活等有机... 新时代的“美好生活”叙事具有深刻的当代中国语境。“美好生活”是一个总体性范畴,既有丰富的理论内涵,又有现实的实践指向,同时具有高远的超越性向度。美好物质生活、美好政治生活、美好精神生活、美好社会生活、美好生态生活等有机地构成“美好生活”的基本内容和价值诉求。“美好生活”的成就是一个社会历史过程,在根本上有赖于坚实的物质基础、充分的民主保障、丰厚的文化滋养、良善的秩序基础以及良好的生态环境。因此,“美好生活”的构建有赖于大力发展先进经济、充分发扬人民民主、深度阐扬优秀文化、切实建构公正制度和着力实现人地和解。同时,“美好生活”不是一个静态的实体性存在,而是一个不断超越现存生活状况的社会历史过程。 展开更多
关键词 美好生活 总体性 超越性
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Immune signature profiling identified prognostic factors for gastric cancer 预览
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作者 Wenhui Yang Zhiyong Lai +4 位作者 Yuan Li Jianbing Mu Mudan Yang Jun Xie Jun Xu 《中国癌症研究:英文版》 SCIE CAS CSCD 2019年第3期463-470,共8页
Objective: Tumor microenvironment, especially the host immune system, plays a pivotal role in tumor initiation and progression. Profiling of immune signature within tumor might uncover biomarkers for targeted therapie... Objective: Tumor microenvironment, especially the host immune system, plays a pivotal role in tumor initiation and progression. Profiling of immune signature within tumor might uncover biomarkers for targeted therapies and clinical outcomes. However, systematic analysis of immune-related genes in gastric cancer(GC) has not been reported.Methods: Expressions of a total of 718 immune-related genes were generated in 372 stomach adenocarcinoma(STAD) patients from The Cancer Genome Atlas(TCGA) database using RNA-sequencing data. Integrated bioinformatics analyses were performed to identify prognostic factors as well.Results: Survival analyses revealed 73 genes, which were significantly associated with patient’s overall survival(OS). Taken together with clinicopathological parameters, we established a predictive model, containing 10 immune-related genes, which were NRP1, C6, CXCR4, LBP, PNMA1, TLR5, ITGA6, MICB, PBK and TNFRSF18,with powerful efficiency in distinguishing satisfactory or poor survival of STAD patients. Moreover, the top 3 ranked prognostic genes, NRP1, TGFβ2 and MFGE8, were also significantly associated with patient’s OS by an independent validation achieved from Kaplan-Meier plotter database.Conclusions: We profiled prognostic immune signature and established prognostic predictive model for GC,which could reflect immune disorders within tumor microenvironment, and also may provide novel predictive and therapeutic targets for GC patients in the near future. 展开更多
关键词 Gastric cancer STOMACH ADENOCARCINOMA IMMUNE prognosis overall survival
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Correlation of radiotherapy with prognosis of elderly patients with hormone receptor-positive breast cancer according to immunohistochemical subtyping 预览
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作者 Xiangcheng Zhi Xiaonan Yang +5 位作者 Teng Pan Jingjing Liu Xiao Chen Liping Lou Zhendong Shi Jin Zhang 《中国癌症研究:英文版》 SCIE CAS CSCD 2019年第3期471-480,共10页
Objective: The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone receptor-positive early breast cancer.Methods: A retrospective analysis of 327 patients aged... Objective: The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone receptor-positive early breast cancer.Methods: A retrospective analysis of 327 patients aged ≥65 years, with stage I-II, hormone receptor-positive breast cancer who underwent breast-conserving surgery and received endocrine therapy(ET) or radiotherapy plus endocrine therapy(ET+RT) was performed. Both groups were divided into luminal A type and luminal B type subgroups. Evaluation criteria were 5-year disease-free survival(DFS), local relapse rate(LRR), overall survival(OS), and distant metastasis rate(DMR).Results: There were significant differences in 5-year DFS [hazard ratio(HR)=1.59, 95% confidence interval(95% CI), 1.15-2.19;P=0.005] and LRR(HR=3.33, 95% CI, 1.51-7.34;P=0.003), whereas there were no significant differences in OS and DMR between ET group and ET+RT group. In luminal A type, there was no significant difference in 5-year DFS, LRR, OS and DMR between ET group and ET+RT group. In luminal B type,there were statistically significant differences in 5-year DFS(HR=2.19, 95% CI, 1.37-3.49;P=0.001), LRR(HR=5.45, 95% CI, 1.65-17.98;P=0.005), and OS(HR=1.75, 95% CI, 1.01-3.05;P=0.048) between ET group and ET+RT group. In the ET group, there were significant differences between luminal A type and luminal B type in5-year DFS(HR=1.84, 95% CI, 1.23-2.75;P=0.003) and OS(HR=1.76, 95% CI, 1.07-2.91;P=0.026).Conclusions: After breast-conserving surgery, radiotherapy can reduce the LRR and improve the DFS and OS of luminal B type elderly patients, whereas luminal A type elderly patients do not benefit from radiotherapy.Without radiotherapy, luminal A type patients have better DFS and OS than luminal B type patients. 展开更多
关键词 BREAST-CONSERVING surgery disease-free SURVIVAL endocrine therapy hormone receptor-positive overall SURVIVAL RADIOTHERAPY
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On the Planning of Chinese Marine High-tech Industry Demonstration Zones:From the Perspective of Supply-side Structural Reform 预览
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作者 Zhang Jian Sui Yanhui +2 位作者 Yu Hai Liu Fujiang Xu Qingtong(译) 《当代社会科学(英文)》 2019年第1期113-122,共10页
China’s national agricultural high-tech industry demonstration zones focus on supply-side structural reform in their overall plan of development.This paper selected the China’s marine industry as its research subjec... China’s national agricultural high-tech industry demonstration zones focus on supply-side structural reform in their overall plan of development.This paper selected the China’s marine industry as its research subject and analyzes its current situation and major problems.After summarizing the current researches of China’s marine industry parks,from the perspective of supply-side structural reform,this paper specifies the tasks and objectives of the construction of the marine hi-tech industry demonstration zones.The overall planning of the demonstration zones must set distinctive developmen as its orientation,and we should emphasize innovation-driven and green development,devise a functional zoning that embraces marine-land and allround integration,and seek mechanism innovations that could invigorate the inner drive of development.The paper also puts forward the major principles that the planning of marine hi-tech industry demonstration zones should obey in the context of supply-side structural reform. 展开更多
关键词 supply-side structural REFORM marine INDUSTRY HI-TECH INDUSTRY demonstrationzone overall PLANNING innovation-driven
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Complex Sequence Quality Evaluation Model for Concealed Water Supply Pipeline of Prefabricated Construction 预览
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作者 韩莎莎 陈群 +1 位作者 李杰 戴一璟 《东华大学学报:英文版》 EI CAS 2019年第2期179-186,共8页
The accurate assessment of the quality can materially affect the safety and life of the prefabricated construction.In this paper,we studied the overall module of concealed water supply pipeline,and a new complex seque... The accurate assessment of the quality can materially affect the safety and life of the prefabricated construction.In this paper,we studied the overall module of concealed water supply pipeline,and a new complex sequence quality evaluation model was established.By analyzing the small evaluation index elements of the model,the weight of the larger evaluation index could be deduced.The total quality evaluation score of the overall module could be obtained by calculating the weight value of the evaluation index,and then the quality standard of the overall module could be obtained. 展开更多
关键词 PREFABRICATED construction concealed water supplypipeline overall MODULE COMPLEX SEQUENCE QUALITY EVALUATION model QUALITY EVALUATION system
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Adjuvant treatment for triple-negative breast cancer: a retrospective study of immunotherapy with autologous cytokine-induced killer cells in 294 patients 预览
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作者 Yuhan Zhang Shuaibing Wang +3 位作者 Beibei Yang Su Lu Yiyi Du Hong Liu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第2期350-360,共11页
Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) patients.Methods: A total of ... Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) patients.Methods: A total of 294 post-surgery TNBC patients participated in the research from January 1, 2009 to January 1, 2015. After adjuvant chemotherapy, autologous CIK cells were introduced in 147 cases(CIK group), while adjuvant chemotherapy alone was used to treat the remaining 147 cases(control group). The major endpoints of the investigation were the disease-free survival(DFS) and overall survival(OS). Additionally, the side effects of the treatment were evaluated.Results: In the CIK group, the DFS and OS intervals of the patients were significantly longer than those of the control group(DFS:P = 0.047;OS: P = 0.007). The multivariate analysis demonstrated that the TNM(tumor-node-metastasis) stage and adjuvant CIK treatment were independent prognostic factors for both DFS [hazard ratio(HR)= 0.520, 95% confidence interval(CI):0.271-0.998, P = 0.049;HR = 1.449, 95% CI:1.118-1.877, P = 0.005, respectively] and OS(HR=0.414, 95% CI:0.190-0.903, P = 0.027;HR= 1.581, 95% CI:1.204-2.077, P = 0.001, respectively) in patients with TNBC. Additionally, longer DFS and OS intervals were associated with increased number of CIK treatment cycles(DFS: P = 0.020;OS: P = 0.040). The majority of the patients who benefitted from CIK cell therapy were relatively early-stage TNBC patients.Conclusion: Chemotherapy in combination with adjuvant CIK could be used to lower the relapse and metastasis rate, thus effectively extending the survival time of TNBC patients, especially those at early stages. 展开更多
关键词 IMMUNOTHERAPY TRIPLE-NEGATIVE breast cancer cytokine-induced KILLER cell prognosis disease-free SURVIVAL overall SURVIVAL
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Holonic Management Tree Technique for Performance Improvement Over Self-Similar System Structures 预览
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作者 Andrea Bonci Sauro Longhi Massimiliano Pirani 《管理研究:英文版》 2019年第5期379-413,共35页
This paper presents the detailed definition of technique for the automation of the management of complex business systems, whether they are constituted of services and productions. The technique has been referred here... This paper presents the detailed definition of technique for the automation of the management of complex business systems, whether they are constituted of services and productions. The technique has been referred here for the first time as Holonic Management Tree (HMT) and has been consistently contextualized into undergoing research on technological frameworks for the management cybernetics, in which the concept of viable system represents a fundamental stance. HMT is based on the use of recursive formulas over self-similar holonic structures for the attainment of continuous performance improvement in a complex and continuously evolving process. The problem is associated to a recursive tree of self-similar structures of which in this paper we discuss the interpretation with respect to knowledge modeling domain. The basic expressions for the computation of the 2nd degree trees are provided and explained in detail by means of an example in lean management context. Moreover, this work presents and discusses the expressions that handle the implementation of the n-th degree case as a recurrent abstraction of the basic and simple 2nd degree computation. 展开更多
关键词 performance improvement overall THROUGHPUT EFFECTIVENESS MANAGEMENT CYBERNETICS COMPLEXITY holonic systems
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Presence of serum antinuclear antibodies correlating unfavorable overall survival in patients with chronic lymphocytic leukemia
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作者 Qian Sun Li Wang +11 位作者 Hua-Yuan Zhu Yi Miao Wei Wu Jin-Hua Liang Lei Cao Yi Xia Jia-Zhu Wu Yan Wang Rong Wang Lei Fan Wei Xu Jian-Yong Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第5期525-533,共9页
Background: Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), prognostic value of ANAs remains unknown. The aim of this study was to evaluate the role of ANAs a... Background: Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), prognostic value of ANAs remains unknown. The aim of this study was to evaluate the role of ANAs as a prognostic factor in CLL. Methods: This study retrospectively analyzed clinical data from 216 newly diagnosed CLL subjects with ANAs test from 2007 to 2017. Multivariate Cox regression analyses were used to screen the independent prognostic factors related to time to first treatment (TTFT), progression free survival (PFS) and overall survival (OS). Receiver operator characteristic curves and area under the curve (AUC) were utilized to assess the predictive accuracy of ANAs together with other independent factors for OS. Results: The incidence of ANAs abnormality at diagnosis was 13.9%. ANAs positivity and TP53 disruption were independent prognostic indicators for OS. The AUC of positive ANAs together with TP53 disruption was 0.766 (95% confidence interval [CI]: 0.697-0.826), which was significantly larger than that of either TP53 disruption (AUC:0.706, 95% CI:0.634-0.772, P=0.034) or positive ANAs (AUC:0.595, 95% CI:0.520-0.668,P<0.001) in OS prediction. Besides, serum positive ANAs as one additional parameter to CLL-international prognostic index (IPI) obtained superior AUCs in predicting CLL OS than CLL-IPI alone. Conclusion: This study identified ANAs as an independent prognostic factor for CLL, and further investigations are needed to validate this finding. 展开更多
关键词 Chronic LYMPHOCYTIC LEUKEMIA ANTINUCLEAR ANTIBODY AUTOIMMUNITY PROGNOSIS Overall survival
Hollow Nanocages of NixCo1-xSe for Efficient Zinc–Air Batteries and Overall Water Splitting
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作者 Zhengxin Qian Yinghuan Chen +4 位作者 Zhenghua Tang Zhen Liu Xiufang Wang Yong Tian Wei Gao 《纳微快报:英文版》 CAS CSCD 2019年第2期140-156,共17页
Developing Earth-abundant,highly efficient,and anticorrosion electrocatalysts to boost the oxygen evolution reaction(OER),oxygen reduction reaction(ORR),and hydrogen evolution reaction(HER) for the Zn–air battery(ZAB... Developing Earth-abundant,highly efficient,and anticorrosion electrocatalysts to boost the oxygen evolution reaction(OER),oxygen reduction reaction(ORR),and hydrogen evolution reaction(HER) for the Zn–air battery(ZAB) and for overall water splitting is imperative.In this study,a novel process starting with Cu2O cubes was developed to fabricate hollow NixCo1-xSe nanocages as trifunctional electrocatalysts for the OER,ORR,and HER and a reasonable formation mechanism was proposed.The Ni0.2Co0.8Se nanocages exhibited higher OER activity than its counterparts with the low overpotential of 280 mV at 10 mA cm-2.It also outperformed the other samples in the HER test with a low overpotential of 73 mV at 10 mA cm-2.As an air–cathode of a self-assembled rechargeable ZAB,it exhibited good performance,such as an ultralong cycling lifetime of > 50 h,a high round-trip efficiency of 60.86%,and a high power density of 223.5 mW cm-2.For the application in self-made all-solid-state ZAB,it also demonstrated excellent performance with a power density of 41.03 mW cm-2 and an open-circuit voltage of 1.428 V.In addition,Ni0.2Co0.8Se nanocages had superior performance in a practical overall water splitting,in which only 1.592 V was needed to achieve a current density of 10 mA cm-2.These results show that hollow NixCo1-xSe nanocages with an optimized Ni-to-Co ratio are a promising cost-effective and high-efficiency electrocatalyst for ZABs and overall water splitting in alkaline solutions. 展开更多
关键词 NixCo1-xSe HOLLOW NANOCAGES Oxygen EVOLUTION REACTION Hydrogen EVOLUTION REACTION Rechargeable/all-solid-state zinc–air battery Overall water splitting
Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma 预览
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作者 Xiao-Hong Xiang Li Yang +9 位作者 Xing Zhang Xiao-Hua Ma Run-Chen Miao Jing-Xian Gu Yu-Nong Fu Qing Yao Jing-Yao Zhang Chang Liu Ting Lin Kai Qu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第14期1715-1728,共14页
BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors ... BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients. AIM To develop a signature of senescence-associated genes (SAGs) that predicts patients’ overall survival (OS) to improve prognosis prediction of HCC. METHODS SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort (GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO (GSE14520) and the Cancer Genome Atlas datasets, respectively. Time-dependent receiver operating characteristic (ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein (AFP). RESULTS A total of 42 SAGs were screened and seven of them, including KIF18B, CEP55, CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells and upregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients’ 1-, 3-, and 5-year OS. CONCLUSION We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC. 展开更多
关键词 Senescence-associated genes HEPATOCELLULAR carcinoma Overall survival Risk model ASIAN patients
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The annual report on the operation of the wool textile industry in 2018 预览
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《中国纺织:英文版》 2019年第3期46-47,共2页
In 2018, the overall operation of the wool textile industry showed an adjustment and transformation trend. The output of major products declined, and the products with large export volume showed a decline too. The dem... In 2018, the overall operation of the wool textile industry showed an adjustment and transformation trend. The output of major products declined, and the products with large export volume showed a decline too. The demand for market transformation and upgrading was urgent. Plus the high raw material prices in the previous three quarters, the burden on enterprises has been further aggravated, and the polarization of the industry has become more apparent. 展开更多
关键词 overall operation BECOME MORE APPARENT
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Overall National Economy Maintained Stable in the First Two Months 预览
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《中国对外贸易:英文版》 2019年第2期40-41,共2页
In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily ... In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018. 展开更多
关键词 Overall NATIONAL ECONOMY Maintained STABLE First TWO MONTHS
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Innovative analysis of predictors for overall survival from systemic non-Hodgkin T cell lymphoma using quantile regression analysis
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作者 Da-Yong Huang Yi-Fei Hu +5 位作者 Na Wei Li Fu Lin Wu Jing Shen Jing-Shi Wang Zhao Wang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第3期294-301,共8页
Background:Non-Hodgkin T/NK cell lymphoma is a rare and widely variable type of lymphoma with the most dismal prognosis. This study aimed to investigate varied impact of the clinical indicators to the overall survival... Background:Non-Hodgkin T/NK cell lymphoma is a rare and widely variable type of lymphoma with the most dismal prognosis. This study aimed to investigate varied impact of the clinical indicators to the overall survival (OS).Methods:We conducted a retrospective study to identify the non-invasive clinical features of T cell lymphoma that can predict prognosis with an innovative analysis method using quantile regression. A total of 183 patients who visited a top-tier hospital in Beijing, China, were enrolled from January 2006 to December 2015. Demographic information and main clinical indicators were collected including age, erythrocyte sedimentation rate (ESR), survival status, and international prognostic index (IPI) score.Results:The median age of the patients at diagnosis was 45 years. Approximately 80% of patients were at an advanced stage, and the median survival time after diagnosis was 5.1 months. Multivariable analysis of the prognostic factors for inferior OS associated with advanced clinical staging [HR=3.16, 95%CI (1.39-7.2)], lower platelet count [HR=2.57, 95%CI (1.57-4.19), P<0.001] and higher IPI score [HR=1.29, 95%CI (1.01-1.66), P=0.043]. Meanwhile, T cell lymphoblastic lymphoma [HR=0.40, 95%CI (0.20-0.80), P=0.010], higher white blood cell counts [HR=0.57, 95%CI (0.34-0.96), P=0.033], higher serum albumin level [HR=0.6, 95%CI (0.37-0.97), P=0.039], and higher ESR [HR=0.53, 95%CI (0.33-0.87), P=0.011] were protective factors for OS when stratified by hemophagocytic lymphohistiocytosis (HLH). Multivariable quantile regression between the OS rate and each predictor at quartiles 0.25, 0.5, 0.75, and 0.95 showed that the coefficients of serum β2-microglobulin level and serum ESR were statistically significant in the middle of the coefficient curve (quartile 0.25-0.75). The coefficient of IPI was negatively associated with OS. The coefficients of hematopoietic stem cell transplantation (HSCT) and no clinical symptoms were higher at the middle of the quartile level curve but were not statistically signifi 展开更多
关键词 SYSTEMIC NON-HODGKIN T cell LYMPHOMA Overall survival QUANTILE regression ANALYSIS
Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study 预览
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作者 Zhao-Qing Du Jun-Zhou Zhao +8 位作者 Jian Dong Jian-Bin Bi Yi-Fan Ren Jia Zhang Bilawal Khalid Zheng Wu Yi Lv Xu-Feng Zhang Rong-Qian Wu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第28期3798-3807,共10页
BACKGROUND Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral antic... BACKGROUND Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral anticoagulants including aspirin. However, the long-term impact of postoperative aspirin on cirrhotic patients after splenectomy remains unknown. AIM The main purpose of this study was to investigate the effect of postoperative long-term low-dose aspirin administration on the development of HCC and longterm survival of cirrhotic patients after splenectomy. METHODS The clinical data of 264 adult patients with viral hepatitis-related cirrhosis who underwent splenectomy at the First Affiliated Hospital of Xi’an Jiaotong University from January 2000 to December 2014 were analyzed retrospectively. Among these patients, 59 who started taking 100 mg/d aspirin within seven days were enrolled in the aspirin group. The incidence of HCC and overall survival were analyzed.RESULTS During follow-up, 41 (15.53%) patients developed HCC and 37 (14.02%) died due to end-stage liver diseases or other serious complications. Postoperative longterm low-dose aspirin therapy reduced the incidence of HCC from 19.02% to 3.40% after splenectomy (log-rank test, P=0.028). Univariate and multivariate analyses showed that not undertaking postoperative long-term low-dose aspirin therapy [odds ratio (OR)=6.211, 95% confidence interval (CI): 1.142-27.324, P=0.016] was the only independent risk factor for the development of HCC. Similarly, patients in the aspirin group survived longer than those in the control group (log-rank test, P=0.041). Univariate and multivariate analyses showed that the only factor that independently associated with improved overall survival was postoperative long-term low-dose aspirin therapy [OR = 0.218, 95%CI: 0.049- 0.960, P=0.044]. CONCLUSION In patients with viral hepatitis-related cirrhosis, long-term post-splenectomy administration of low-dose aspirin reduces the incidence of HCC and improves the long-term 展开更多
关键词 ASPIRIN SPLENECTOMY PROGNOSIS HEPATOCELLULAR carcinoma Overall survival
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Transfer matrix method for multibody systems(Rui method) and its applications
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作者 RUI XiaoTing WANG Xun +1 位作者 ZHOU QinBo ZHANG JianShu 《中国科学:技术科学英文版》 SCIE EI CAS CSCD 2019年第5期712-720,共9页
The transfer matrix method for multibody systems, namely the 'Rui method', is a new method for studying multibody system dynamics, which avoids the global dynamics equations of the system, keeps high computati... The transfer matrix method for multibody systems, namely the 'Rui method', is a new method for studying multibody system dynamics, which avoids the global dynamics equations of the system, keeps high computational speed, and allows highly formalized programming. It has been widely applied to scientific research and key engineering of lots of complex mechanical systems in 52 research directions. The following aspects regarding the transfer matrix method for multibody systems are reviewed systematically in this paper: history, basic principles, formulas, algorithm, automatic deduction theorem of overall transfer equation, visualized simulation and design software, highlights, tendency, and applications in 52 research directions in over 100 key engineering products. 展开更多
关键词 MULTIBODY system dynamics TRANSFER matrix METHOD for MULTIBODY systems Rui METHOD automatic DEDUCTION THEOREM of overall TRANSFER equation theory computation software APPLICATIONS
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