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An Ethical Practice Intervention Program for Pediatric Nurses with Varied Nursing Experience 认领
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作者 Naomi Matsumori 《护理学期刊(英文)》 2020年第4期411-428,共18页
Aim: This study aimed to elucidate experience-related differences in the impact of an intervention program promoting ethical nursing practices among pediatric nurses with 0 - 5 years’ experience in varying settings. ... Aim: This study aimed to elucidate experience-related differences in the impact of an intervention program promoting ethical nursing practices among pediatric nurses with 0 - 5 years’ experience in varying settings. Methods: The pediatric nursing care model, defining 24 elements of pediatric nursing practice, was developed to educate nurses with pediatric nursing experience only, as well as those with experience in other settings, on ethical nursing practices toward pediatric patients and their families. Participants’ level of knowledge and frequency of application of these practices were assessed before, directly after and two months after the intervention, with a final follow-up three months post-intervention. Results: Results showed that among those who have experience in nursing areas other than pediatrics, the frequency of practicing items related to children’s rights and dignity significantly increased (p Conclusions: Participants showed an increased awareness of issues related to ethical pediatric nursing practice for patients’ and their parents. 展开更多
关键词 ETHICAL NURSING Practice NURSING EDUCATION PEDIATRIC NURSING PEDIATRIC PATIENT CARE
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Pleuropulmonary Blastoma in Pediatric Age Group: A Very Rare Case Report and Review of Literature 认领
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作者 Kalpesh Onkar Patil 《儿科学期刊(英文)》 2020年第1期109-115,共7页
Pleuropulmonary blastoma (PPB) is a very rare and very aggressive malignant tumor that affects children and adults. Though its presentation in children has been reported in literature, incidence is very low as compare... Pleuropulmonary blastoma (PPB) is a very rare and very aggressive malignant tumor that affects children and adults. Though its presentation in children has been reported in literature, incidence is very low as compared to adults. This neoplasm is characterized on histology by primitive blastema and a malignant mesenchymal stroma that often demonstrates multidirectional differentiation. Even though availability of multimodal therapy, the prognosis of patients with PPB remains poor. 展开更多
关键词 Pleuropulmonary Blastoma RARE PEDIATRIC LUNG CANCERS RARE CAUSES of Solid LUNG LESIONS
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A Survey of Research on Treatment of Pediatric Diarrhea with Massage Ying-Ming 认领
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作者 Ying-Ming Sun Na Sun Ying Wang 《TMR食疗与健康管理》 2020年第3期109-114,共6页
Pediatric diarrhea is a common pediatric disease.Massage has broad application prospects in the treatment of pediatric diarrhea,which is an ideal treatment for pediatric diarrhea.In this paper,the etiology analysis of... Pediatric diarrhea is a common pediatric disease.Massage has broad application prospects in the treatment of pediatric diarrhea,which is an ideal treatment for pediatric diarrhea.In this paper,the etiology analysis of pediatric diarrhea,classification of traditional Chinese medicine(TCM),massage techniques and other aspects were reviewed.In order to provide reference for the clinical application of pediatric massage in the treatment of diarrhea. 展开更多
关键词 Pediatric massage Pediatric diarrhea External therapy REVIEW
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我国2009-2018年儿童药物经济学研究文献质量评价 认领
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作者 徐蔼琳 李文君 +1 位作者 卢梦情 席晓宇 《中国药房》 CAS 北大核心 2020年第6期718-723,共6页
目的:为提高我国儿童药物经济学研究水平提供参考。方法:以"儿童""药物经济学""成本-效果""成本-效益""成本-效用""最小成本"等为关键词,检索中国知网、万方、维普、中国... 目的:为提高我国儿童药物经济学研究水平提供参考。方法:以"儿童""药物经济学""成本-效果""成本-效益""成本-效用""最小成本"等为关键词,检索中国知网、万方、维普、中国生物医学文献数据库中2009年1月-2018年12月发表的儿童药物经济学研究文献,采用儿童药物经济学质量评价问卷对纳入文献进行质量评价,分析现有文献存在的问题并提出建议。结果与结论:共纳入儿童药物经济学研究文献140篇。发文数量总体呈增长态势,期刊分布松散;第一作者以医疗机构为主,主要涉及呼吸系统疾病以及药物治疗等。其中,15篇研究文献注明了研究角度,109篇研究时限≤1年,6篇进行了敏感性分析,多采用成本-效果分析和决策分析模型。质量评价结果显示,纳入的140篇文献在经济评价、比较方案、目标人群、产出、分析、结论等维度得分较高(0.62~1.00分),时间范围和贴现维度得分一般(分别为0.49分和0.53分),但研究视角、成本和资源使用、增量分析、敏感性分析、利益冲突等维度得分较低(0.10~0.31分)。我国儿童药物经济学研究所存在的问题集中于研究视角选取、成本与临床数据收集测算、分析方法选用等方面。建议《中国药物经济学评价指南》补充儿童药物经济学方法学内容,以指导儿童药物经济学相关研究;同时,相关学者开展儿童药物经济学研究应从明确研究视角、规范成本识别测量方法、合理选择健康产出指标、正确运用分析方法等方面进一步提升其研究质量。 展开更多
关键词 质量评价 药物经济学 儿童 儿童药物经济学质量评价问卷 中国
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Immunotherapy for the Post-Infectious Sequela of SARS-CoV-2 Infection 认领
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作者 David S. Younger 《神经科学国际期刊(英文)》 2020年第2期117-120,共4页
The SARS-CoV-2 2019 pandemic is creating challenges to the management of post-infectious autoimmunity in childhood and adult Covid-19 cases due to its high case fatality. Nearly all of the agents envisioned to treat C... The SARS-CoV-2 2019 pandemic is creating challenges to the management of post-infectious autoimmunity in childhood and adult Covid-19 cases due to its high case fatality. Nearly all of the agents envisioned to treat Covid-19 illness, including the newly recognized pediatric multi-system inflammatory syndrome, impact post-infectious mechanisms in keeping with the multiplier effect of infection, immunity and inflammation, known as I-Cubed (I3). 展开更多
关键词 SARS-CoV-2 Covid-19 Intravenous Immune GLOBULIN IVIG Pediatric MULTI-SYSTEM Inflammatory Syndrome
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Surgical Outcomes of Nontraumatic Pediatric Cataracts 认领
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作者 Aslihan Uzun Huban Atilla 《眼科学期刊(英文)》 2020年第2期115-122,共8页
Purpose: To evaluate post-surgical complications in patients who were operated for nontraumatic pediatric cataracts in our clinic. Methods: Medical records of 62 patients (101 eyes) that underwent cataract surgery you... Purpose: To evaluate post-surgical complications in patients who were operated for nontraumatic pediatric cataracts in our clinic. Methods: Medical records of 62 patients (101 eyes) that underwent cataract surgery younger than 15 years of age, without history of ocular trauma and with a minimum follow-up period of 6 months, were reviewed retrospectively. Results: The most common initial complaint was leukocoria. Thirty-nine patients (62.9%) had bilateral cataracts and 23 patients (37.1%) had unilateral cataracts. The most common type was posterior polar cataract (22%) in patients with unilateral cataracts, and total cataract (33%) in patients with bilateral cataracts. The overall prevalence of postoperative complications was 58%, visual axis opacification (VAO) being the most common one (39%). The incidence of VAO was significantly higher in eyes with intact posterior capsules. Secondary glaucoma occurred in 12 (12%) eyes. Thirty-one (50%) patients were orthophoria, 17 (27%) patients had esotropia, and 14 (23%) patients had exotropia. Additional surgery for all of these complications was performed in 53 (53%) eyes. Conclusions: Despite appropriate surgical treatment of nontraumatic pediatric cataracts, post-surgical complications including VAO, glaucoma, or strabismus remain an important cause of morbidity in these patients. Posterior capsulotomy and anterior vitrectomy must be performed in all children below 6 years to reduce the need for additional surgery for VAO. 展开更多
关键词 CONGENITAL CATARACT PEDIATRIC CATARACT Visual AXIS OPACIFICATION GLAUCOMA Surgery
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Endoscopic Third Ventriculostomy versus Ventriculo-Peritoneal Shunt for Infant Hydrocephalus 认领
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作者 Khaled Ismail Abdel-Aziz Radwan Nouby +1 位作者 Mahmoud Ahmed Thabet Mohammad Fekry Elshirbiny 《现代神经外科学进展(英文)》 2020年第2期193-202,共10页
Introduction: Patients with hydrocephalus, which is the most pediatric neurological disorder, undergo Cerebrospinal fluid (CSF) diversion through third ventriculostomy or ventriculo-peritoneal shunt. Up to date, the o... Introduction: Patients with hydrocephalus, which is the most pediatric neurological disorder, undergo Cerebrospinal fluid (CSF) diversion through third ventriculostomy or ventriculo-peritoneal shunt. Up to date, the optimal hydrocephalus treatment modality is not clear. Aim: We compared the outcome of endoscopic third ventriculostomy (ETV) versus ventriculo-peritoneal shunt (VP shunt) as a second surgical intervention in management of Infant hydrocephalus concerning success rate and complications. Patients and Methods: We conducted an observational study of 52 children with hydrocephalus (congenital or acquired) in whom CSF diversion was performed using either ETV or VP shunt in randomized control trial. Results: During the period examined, 52 children, 26 underwent ETV and 26 underwent VP shunt. The mean age was 11.0 ± 4.3 months in ETV and 11.3 ± 4.7 months in VP shunt. Postoperative infection in the ETV group was lower than in the VP shunt group (23.1% vs. 53.8% P = 0.045). Regarding operating time, In ETV group operation duration was 46.9 min and 64.3 min in the V-P shunt group (P = 0.13). There was no statistically significant difference between the two study groups regarding the rate of obstruction, change in occipital frontal circumference (OFC) or the need of revision surgery. One year survival for VP shunt group vs. ETV group was 46.2% vs. 65.4% respectively. Conclusion: ETV associated with lower rates of postoperative infection and shorter operation time with no significant difference in rates of obstruction, change in OFC and revision surgery in comparison to VP shunt. 展开更多
关键词 ETV VPS PEDIATRIC HYDROCEPHALUS
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Comment on pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality 认领
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作者 Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第30期4564-4566,共3页
Since the first successful liver transplantation was performed five decades ago,pediatric liver transplantation has become the gold standard treatment choice for pediatric liver disease,including metabolic diseases,li... Since the first successful liver transplantation was performed five decades ago,pediatric liver transplantation has become the gold standard treatment choice for pediatric liver disease,including metabolic diseases,liver tumors,and some acute liver failure.With improvements in immunosuppression,surgical techniques,and postoperative medical care,long-term outcomes of patients after liver transplantation have markedly improved,especially in pediatric patients. 展开更多
关键词 Pediatric end stage liver disease Living donor pediatric liver transplantation Survival analysis Risk factors Living donor liver transplantation OUTCOMES
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Pediatric Hypertension (HTN) Assessed by Various Methods: A Study among Pediatric Inpatients in University Hospital Gabriel Touré(UH-GT) 认领
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作者 Hamidou Oumar Ba Youssouf Camara +18 位作者 Ibrahima Sangare Maiga Belco Diakite Mamadou A. Dembele Fofana Cheick Hamala Toure Mamadou Hamidou Camara Sogodogo Adama Traore Aladji Sidibe Samba Sidibe Noumou Doumbia Coumba Thiam Maiga Asmaou Kéita Konate Massama Sonfo Boubacar Menta Ichaka Ilo Bella Diall Togo Boubacar Diarra Mamadou Bocary 《心血管病(英文)》 2020年第3期144-154,共11页
Introduction: It is known for decades that a correlation among child blood pressure and adult pressure exist. There are few publications on Hypertension (HTN) in pediatric area. We therefore conducted this study to es... Introduction: It is known for decades that a correlation among child blood pressure and adult pressure exist. There are few publications on Hypertension (HTN) in pediatric area. We therefore conducted this study to estimate the extension of HTN among children and looking for associated factors. Methods: Blood pressure was assessed using the references released by the National institutes of health in the United States, those of the French Society of Pediatric Nephrology and z-score. We used the auscultation method with appropriate cuff adapted to the child’s upper arm. We got for each arm 3 blood pressure measures taken children seated or lying on the back and mean blood pressure was calculated and used for the evaluation of the pressure level. The arm with the higher blood pressure was considered for the study. Socio-demographical and clinical data were collected anonymously on a formulary and then inserted in a Microsoft Access Database. Analysis was done using Statistical Package for the Social Sciences (SPSS) software using appropriate tests. Results: The study involved 154 patients (boys:girls = 56.5:43.5) aged 3 to 16 years. Patients of 11 years and older made 57.1% of the sample. Most patients suffered from severe malaria (35.1%, glomerular and heart diseases with respectively 16.2% and 9.1%. The global proportion of hypertensive patients was 27%, 39% and 5.2% respectively based on references of the French society of nephrology, those of the 4th report of the NHBPEP and standard deviation. Looking for associated factors with hypertension the logistic regression found no predictor for hypertension using pressure cut-offs values based on the French society of nephrology and those of the 4th report of the National High Blood Pressure Education Programm (NHBPEP). Conclusion: Children must be checked for hypertension to avoid organ damage and later cardiovascular complications. Blood pressure assessment should be preferably done on outpatients as the role of the stressful hospitalization environment can be att 展开更多
关键词 HYPERTENSION PEDIATRIC BAMAKO
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Treatment of Pediatric Brain Tumors in Brazzaville (Congo) about a Case Series 认领
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作者 Hugues Brieux Ekouele Mbaki Léon Boukassa +3 位作者 Olivier Brice Ngackosso Sinclair Brice Kinata Bambino Gedeon Colin Thouassa Rel Gerald Boukaka Kala 《现代神经外科学进展(英文)》 2020年第1期27-35,共9页
Introduction: Tumors of the central nervous system are the most common group of solid neoplasm in children and account for 20% to 25%. They are common in Sub-Saharan countries, despite the insufficiency of histologica... Introduction: Tumors of the central nervous system are the most common group of solid neoplasm in children and account for 20% to 25%. They are common in Sub-Saharan countries, despite the insufficiency of histological diagnosis. No study has been performed concerning the pediatric brain tumors in the Republic of Congo. The aim of this study was to describe the conditions of neurosurgical management of pediatric tumors in Brazzaville. Materials and Methods: We performed a retrospective and descriptive study, from January 2014 to December 2017 (48 months), into the neurological unit of the surgical department of Brazzaville. We included all patients aged from 17 years old and below, hospitalized for a brain tumor. Results: We have identified 11 cases of brain tumors. The average age was 8.1 ± 4.3 years old, a sex ratio of 0.57. Ten out of the eleven patients of our series have intracranial hypertension. We found six cases of infratentorial tumors and five of supratentorial location. Only three cases had histology. Ten patients were operated, limited by ventriculoperitoneal shunt in 6 cases, surgical resection in three cases, biopsy in one case. There were no possibilities of radiotherapy and chemotherapy during this period of study. Conclusion: A multidisciplinary team must be organized to improve the management of pediatric brain tumors in our context. Histological diagnosis and possibilities of radiotherapy are imperatively needed. 展开更多
关键词 PEDIATRIC Brain Tumor POSTERIOR Fossa TUMORS Surgical RESECTION BRAZZAVILLE
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文章速递江苏省儿科医务人员对新冠肺炎的认知程度及影响因素研究 认领
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作者 姚银蓥 周亮亮 缪红军 《江苏卫生事业管理》 2020年第10期1261-1266,共6页
目的:了解江苏省儿科医务人员对新冠肺炎的认知水平并分析其影响因素,为抗击新冠肺炎疫情提供参考。方法:以江苏省儿科医务人员群体为对象进行问卷调查,主要包括人员基本情况和了解分析各类人员对新冠肺炎相关知识的掌握情况。结果:本... 目的:了解江苏省儿科医务人员对新冠肺炎的认知水平并分析其影响因素,为抗击新冠肺炎疫情提供参考。方法:以江苏省儿科医务人员群体为对象进行问卷调查,主要包括人员基本情况和了解分析各类人员对新冠肺炎相关知识的掌握情况。结果:本调查有效问卷回收率98.25%,儿科医务人员对新冠肺炎的治疗认知程度最高,其次是对新冠肺炎预防的认知程度,对新冠肺炎的检测与诊断认知程度最低。通过Logistic回归分析,发现职称、医院类型、是否参与抗疫救治工作、单位是否积极开展新冠肺炎相关知识培训是影响江苏省儿科医务人员认知的主要因素。结论:相关部门应加强医务人员对新冠肺炎相关知识的培训与指导,加大宣传推广,儿科医务人员应主动提升医疗诊治水平,快速熟悉救治流程。 展开更多
关键词 新冠肺炎 儿科 医务人员 认知程度 影响因素
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文章速递Impact of pediatric traumatic brain injury on hippocampal neurogenesis 认领
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作者 Mariam Rizk Justin Vu Zhi Zhang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2021年第5期926-933,共8页
Traumatic brain injury(TBI)is a major cause of mortality and morbidity in the pediatric population.With advances in medical care,the mortality rate of pediatric TBI has declined.However,more children and adolescents a... Traumatic brain injury(TBI)is a major cause of mortality and morbidity in the pediatric population.With advances in medical care,the mortality rate of pediatric TBI has declined.However,more children and adolescents are living with TBI-related cognitive and emotional impairments,which negatively affects the quality of their life.Adult hippocampal neurogenesis plays an important role in cognition and mood regulation.Alterations in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases,including TBI.Promoting endogenous hippocampal neurogenesis after TBI merits significant attention.However,TBI affects the function of neural stem/progenitor cells in the dentate gyrus of hippocampus,which results in aberrant migration and impaired dendrite development of adult-born neurons.Therefore,a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature brains.Secondary injuries,such as neuroinflammation and oxidative stress,exert a significant impact on hippocampal neurogenesis.Currently,a variety of therapeutic approaches have been proposed for ameliorating secondary TBI injuries.In this review,we discuss the uniqueness of pediatric TBI,adult hippocampal neurogenesis after pediatric TBI,and current efforts that promote neuroprotection to the developing brains,which can be leveraged to facilitate neuroregeneration. 展开更多
关键词 adult hippocampal neurogenesis astrocytes development microglia neuroinflammation neuroregeneration oxidative stress pediatric traumatic brain injury plasticity stem cell
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文章速递儿科五脏辨证学说源流和特点 认领
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作者 李相珍 黄岩杰 +1 位作者 彭超群 丁雪颖 《中医杂志》 CSCD 北大核心 2020年第20期1771-1774,共4页
为深入探寻儿科五脏辨证学说的发展轨迹、具体内容、学术特点和传承价值,概述了该学说形成和发展的历程、著名医家的贡献,以及与八纲辨证、病因辨证等辨证模式之间的相互影响。结合钱乙《小儿药证直诀》对五脏疾病证候的记述,总结出钱... 为深入探寻儿科五脏辨证学说的发展轨迹、具体内容、学术特点和传承价值,概述了该学说形成和发展的历程、著名医家的贡献,以及与八纲辨证、病因辨证等辨证模式之间的相互影响。结合钱乙《小儿药证直诀》对五脏疾病证候的记述,总结出钱乙将虚、实作为把握五脏病机演变的核心要素,化繁为简,提炼辨证要点,准确指导临床施治,实用价值历久弥新。儿童生理病理特点的独特性决定了儿科五脏辨证学说产生、存在和发展的必然性。 展开更多
关键词 五脏辨证 儿科 钱乙
便携式血气分析仪在儿科血气分析中的应用 认领
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作者 邓芳帆 《中国医疗器械信息》 2020年第13期158-159,184,共3页
目的:探讨便携式血气分析仪在儿科血气分析中的应用。方法:选取2018年10月~2019年5月本院儿科需血气分析的100例患儿作为研究对象,使用随机数字表示法分为对照组与观察组,两组各50例。予以对照组生化室检测,给予观察组便携式血气分析仪... 目的:探讨便携式血气分析仪在儿科血气分析中的应用。方法:选取2018年10月~2019年5月本院儿科需血气分析的100例患儿作为研究对象,使用随机数字表示法分为对照组与观察组,两组各50例。予以对照组生化室检测,给予观察组便携式血气分析仪检测。对比分析两组血气分析结果及采血量和检测时间。结果:观察组血气分析结果与对照组无显著差异(P>0.05);观察组采血量和结果回报时间少于对照组(P<0.05)。结论:在儿科血气分析中使用便携式血气分析仪,检验结果准确,采血量及检测时间较少,对提升幼儿治疗安全性有积极意义。 展开更多
关键词 血气分析 便携式血气分析仪 儿科
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Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model 认领
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作者 Hongzhi Wang Emily W.Baker +3 位作者 Abhyuday Mandal Ramana M.Pidaparti Franklin D.West Holly A.Kinder 《中国神经再生研究:英文版》 SCIE CAS 2021年第2期338-344,共7页
Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;ho... Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia Institutional Animal Care and Use Committee(AUP: 展开更多
关键词 controlled cortical impact gait analysis linear regression magnetic resonance imaging motor function pediatric pig model principal component analysis traumatic brain injury
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儿童晕厥:热点问题 认领
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作者 陶春燕 唐朝枢 +1 位作者 金红芳 杜军保 《科学通报:英文版》 SCIE EI CAS CSCD 2020年第7期513-515,M0003共4页
Syncope,a transient loss of consciousness due to global cerebral hypoperfusion,is common in the young.Around 15%–20%of children and adolescents experience at least one episode of syncope,which greatly impacts their l... Syncope,a transient loss of consciousness due to global cerebral hypoperfusion,is common in the young.Around 15%–20%of children and adolescents experience at least one episode of syncope,which greatly impacts their life quality.Therefore,continuous improvement of the management of syncope is an important issue in the field.On August 24th,2019,the 7th congress on pediatric syncope in China was held in Changsha,China.Over 300 participants from 11 countries attended the conference,at which the treatment progress of pediatric syncope was actively discussed. 展开更多
关键词 PERFUSION CEREBRAL PEDIATRIC
脑瘫儿认知功能损害的3T多模态脑功能MR成像 认领
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作者 张晓凡 郝明珠 +7 位作者 王志伟 王芳 朱凯 张毅 刘畅 曾立红 丁凤姝 汪洋 《中国医学计算机成像杂志》 CSCD 北大核心 2020年第1期1-8,共8页
目的:探索BOLD及DKI磁共振功能成像技术在认知功能损害脑瘫儿的应用。方法:选取伴有认知功能障碍脑瘫患儿(CP组)52例及正常小儿(CG组)50例,使用PhilipsIngenia3.0T多模态磁共振功能成像技术,在静息状态下行高分辨T1WI、BOLD及可行性DKI... 目的:探索BOLD及DKI磁共振功能成像技术在认知功能损害脑瘫儿的应用。方法:选取伴有认知功能障碍脑瘫患儿(CP组)52例及正常小儿(CG组)50例,使用PhilipsIngenia3.0T多模态磁共振功能成像技术,在静息状态下行高分辨T1WI、BOLD及可行性DKI扫描,采集统计及分析MR功能数据。结果:CP组与CG组比较:①BOLD成像ALFF值:左丘脑、左壳核、左楔前回及右角回、右扣带回后部的ALFF值升高(P <0.05)。②ReHo值:左额上回、左岛叶皮质、左枕回、右额中回、右颞上回Reho值降低(P<0.05);左额叶白质、左顶下小叶、左丘脑、右额叶白质、右扣带回Reho值升高(P <0.05)。③DKI成像MK值:CP组双额叶、双顶叶、双枕叶MK值均低于CG组(P <0.05)。结论:RS-fMRI为无创性敏感研究认知功能障碍脑瘫儿脑灰白质功能、微观结构及病损的重要影像学方法。 展开更多
关键词 脑瘫 血氧水平依赖功能成像 扩散峰度成像 小儿
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热炎宁合剂的非临床幼年动物毒理学研究 认领
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作者 周晓冰 郭隽 +8 位作者 曹兆军 褚亚军 霍桂桃 屈哲 杨莹 赵婷婷 王伟凡 耿兴超 张河战 《中国药事》 CAS 2020年第9期1040-1046,共7页
目的:采用幼年动物对热炎宁合剂进行毒理学研究,进一步为其儿科用药提供临床前安全性数据。方法:采用10日龄SD大鼠连续36天灌胃给予热炎宁合剂,观察主要毒性靶器官及损害的可逆程度,评估大鼠产生的毒性反应及其严重程度。结果:给药后动... 目的:采用幼年动物对热炎宁合剂进行毒理学研究,进一步为其儿科用药提供临床前安全性数据。方法:采用10日龄SD大鼠连续36天灌胃给予热炎宁合剂,观察主要毒性靶器官及损害的可逆程度,评估大鼠产生的毒性反应及其严重程度。结果:给药后动物出现棕褐色水样便,与药物的药效作用相关;而深黄色尿液症状可能与受试物本身性状相关。离乳前高剂量组雌、雄动物体重下降,给药初期高剂量组雌、雄动物体重增长幅度减少;给药结束时高剂量组雌、雄动物血红蛋白、红细胞比容降低,雄性动物网织红细胞含量及比例升高;给药结束时高剂量组雌性动物血清中甘油三脂含量升高;给药组雌、雄性动物尿比重、尿酮体增加,尿颜色加深,雄性动物尿隐血含量增加、尿白细胞含量增加;以上指标在恢复期结束时均可恢复。此外,未观察到热炎宁合剂对其他指标的影响。给药组动物尿生化指标的变化并未观察到相应肾脏组织病理学的明显改变。结论:在本试验条件下,热炎宁合剂对幼龄动物不产生明显毒性作用的剂量为65.1 g/kg(相当于生药量)。这些结果为临床儿科剂量及毒副反应的监测提供参考依据。 展开更多
关键词 热炎宁合剂 幼年动物 儿科 毒理学研究
高频振荡通气治疗小儿重度肺源性急性呼吸窘迫综合征的疗效分析 认领
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作者 耿文锦 张若璇 +3 位作者 靳梅 石晓娜 刘刚 徐梅先 《中国中西医结合急救杂志》 CAS CSCD 北大核心 2020年第4期427-430,共4页
目的评估高频振荡通气(HFOV)治疗小儿重度肺源性急性呼吸窘迫综合征(ARDSp)的临床疗效。方法选择河北省儿童医院2015年1月至2018年7月收治的ARDSp患儿28例,在采用常频机械通气(CMV)失败后行HFOV治疗。参数设置:初始设置平均气道压较CMV... 目的评估高频振荡通气(HFOV)治疗小儿重度肺源性急性呼吸窘迫综合征(ARDSp)的临床疗效。方法选择河北省儿童医院2015年1月至2018年7月收治的ARDSp患儿28例,在采用常频机械通气(CMV)失败后行HFOV治疗。参数设置:初始设置平均气道压较CMV时高2~3 cmH2O(1 cmH2O≈0.098 kPa),吸入氧浓度(FiO2)0.6~1.0,维持经皮脉搏血氧饱和度(SpO2)0.89以上;振幅以观察到胸壁振荡延续到患儿腹股沟处为限,振荡频率为9~12 Hz,偏置气流25~30 L/min;吸气时间百分比初始设置为33%,根据血气水平调整呼吸机参数:动脉血二氧化碳分压(PaCO2)增高时提高振幅,降低频率,反之亦反。观察治疗前及治疗后12、24、48、72 h通气-氧合指标、循环指标的变化以及患儿预后。结果与治疗前比较,HFOV治疗后12、24、48、72 h患儿通气-氧合指标均有明显改善,PaCO2明显降低〔mmHg(1 mmHg≈0.133 kPa):45.7±13.2、41.4±11.7、43.5±12.8、42.4±10.7比52.3±16.1,均P<0.05〕,氧合指数(OI)也明显降低(24.5±2.3、23.7±2.4、22.7±2.5、21.6±1.7比29.7±2.8,均P<0.01),动脉血氧分压和吸入氧浓度比值(PaO2/FiO2)均明显升高(mmHg:115.5±12.2、120.7±14.2、151.8±10.5、113.8±12.6比69.3±11.2,均P<0.01)。随时间延长,HFOV治疗后患儿心率较治疗前逐渐降低并趋向于正常(次/min:147.0±9.4、139.1±11.5、124.1±10.3、125.3±11.6比172.1±9.5,均P<0.01),治疗前后各时间点平均动脉压(MAP)无明显变化(mmHg:50.2±7.6、51.5±8.6、50.6±8.5、51.2±6.3比52.6±7.8,均P>0.05)。本组患儿存活18例,死亡10例(病死率为35.7%)。结论对CMV治疗无效的ARDSp患儿,尽早实施HFOV治疗可有效改善肺部氧合及通气,对血流动力学无不良影响。HFOV可作为ARDSp患儿的重要抢救措施。 展开更多
关键词 高频振荡通气 肺源性急性呼吸窘迫综合征 小儿
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社区营造视角下的医院社会工作——以某院儿科病区为例 认领
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作者 江卫忠 马凯旋 +1 位作者 孙瑛 金钟鸣 《中国医学伦理学》 2020年第9期1116-1119,共4页
从社区营造的概念出发,讨论了社区营造与医院社会工作的关系,并以上海交通大学医学院附属新华医院儿科病区为例,展示了在医院中开展社区营造的主体与目标、主要步骤和内容。为即将初步开展社会工作的医疗机构提供借鉴的经验。
关键词 社区营造 医院社会工作 儿科
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