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A comparison of emissive and cold floating probe techniques for electric potential measurements in rf inductive discharge
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作者 Yaroslav MURZAEV Gen nadii LIZIAKIN +2 位作者 An drey GAVRIKOV Rinat TIMIRKHANOV Valentin SMIRNOV 《等离子体科学与技术:英文版》 SCIE EI CAS CSCD 2019年第4期94-98,共5页
A cold floating probe method was compared with the emissive floating probe method in terms of a low-pressure radio-frequency inductive discharge.The dependences of difference between the plasma potential and the float... A cold floating probe method was compared with the emissive floating probe method in terms of a low-pressure radio-frequency inductive discharge.The dependences of difference between the plasma potential and the floating potential on the electron temperature 1-8 eV,plasma density 109-1012 cm 3 and magnetic field 100-650 G were obtained.It was demonstrated that the difference between the potentials that obtained by these two methods can differ significantly from the expected value of 5.2 kTe/e for argon. 展开更多
关键词 emissive PROBE FLOATING PROBE rf INDUCTIVE DISCHARGE PLASMA potential measurement
Recent progress and challenges in screening and characterization of UGT1A1 inhibitors
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作者 Xia Lv Yangliu Xia +3 位作者 Moshe Finel Jingjing Wu Guangbo Ge Ling Yang 《药学学报:英文版》 CSCD 2019年第2期258-278,共21页
Uridine-diphosphate glucuronosyltransferase 1 A1(UGT1 A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong in... Uridine-diphosphate glucuronosyltransferase 1 A1(UGT1 A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1 A1 may trigger adverse drug/herb–drug interactions, or result in metabolic disorders of endobiotic metabolism. Therefore, both the US Food and Drug Administration(FDA)and the European Medicines Agency(EMA) have recommended assaying the inhibitory potential of drugs under development on the human UGT1 A1 prior to approval. This review focuses on the significance,progress and challenges in discovery and characterization of UGT1 A1 inhibitors. Recent advances in the development of UGT1 A1 probes and their application for screening UGT1 A1 inhibitors are summarized and discussed in this review for the first time. Furthermore, a long list of UGT1 A1 inhibitors, including information on their inhibition potency, inhibition mode, and affinity, has been prepared and analyzed. Challenges and future directions in this field are highlighted in the final section. The information and knowledge that are presented in this review provide guidance for rational use of drugs/herbs in order to avoid the occurrence of adverse effects via UGT1 A1 inhibition, as well as presenting methods for rapid screening and characterization of UGT1 A1 inhibitors and for facilitating investigations on UGT1 A1–ligand interactions. 展开更多
关键词 UGT1A1 INHIBITORS Drug/herbdrug INTERACTIONS Probe SUBSTRATES HIGH-THROUGHPUT SCREENING
广州市社区老年教育的探索与思考 预览
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作者 李坪 李艳娥 《广州城市职业学院学报》 2019年第2期93-95,共3页
我国作为世界人口大国和最大的发展中国家,近年来随着老年人口基数增大、人口老龄化速度加快和经济发展进入新常态,社区老年教育需求日益迫切。我们根据广州本地实际探索开展了城市社区职业教育服务社区互助养老的社区老年教育模式,也... 我国作为世界人口大国和最大的发展中国家,近年来随着老年人口基数增大、人口老龄化速度加快和经济发展进入新常态,社区老年教育需求日益迫切。我们根据广州本地实际探索开展了城市社区职业教育服务社区互助养老的社区老年教育模式,也提出了相应发展城市社区老年教育的对策建议。 展开更多
关键词 城市社区 老年教育 探索
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给排水施工问题的若干探析 预览
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作者 沈周锋 《工程建设(重庆)》 2019年第6期4-5,共2页
随着建筑产业的飞速发展,施工工程的技术质量要求越来越严格,越来越多施工项目开展的同时,人们对建筑物的要求也在逐步提升。给排水工程是建筑施工中极为重要的一环,是建筑工程中的基础设施之一,直接影响到一个建筑物的整体品质。而在... 随着建筑产业的飞速发展,施工工程的技术质量要求越来越严格,越来越多施工项目开展的同时,人们对建筑物的要求也在逐步提升。给排水工程是建筑施工中极为重要的一环,是建筑工程中的基础设施之一,直接影响到一个建筑物的整体品质。而在现实施工中往往会出现很多问题,文章就现存的问题加以探讨并给出些解决方案。 展开更多
关键词 建筑 给排水施工 问题 探析
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Effect of Beam Current and Diameter on Electron Probe Microanalysis of Carbonate Minerals
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作者 Xing Zhang Shuiyuan Yang +3 位作者 He Zhao Shaoyong Jiang Ruoxi Zhang Jing Xie 《地球科学学刊:英文版》 SCIE CAS CSCD 2019年第4期834-842,共9页
The effect of operating conditions on the time-dependent X-ray intensity variation is of great importance for the optimal EPMA conditions for accurate determinations of various elements in carbonate minerals. Beam dia... The effect of operating conditions on the time-dependent X-ray intensity variation is of great importance for the optimal EPMA conditions for accurate determinations of various elements in carbonate minerals. Beam diameters of 0, 1, 2, 5, 10, 15, and 20 μm, and beam currents of 3, 5, 10, 20,and 50 nA were tested. Ca, Mg, Zn, and Sr were found to be more sensitive to electron beam irradiation as compared to other elements, and small currents and large beam diameters minimized the timedependent X-ray intensity variations. We determined the optimal EPMA operating conditions for elements in carbonate: 10 μm and 5 nA for calcite;10 μm and 10 nA for dolomite;5 μm and 10 nA or 10 μm and 20 nA for strontianite;and 20 nA and 5 μm for other carbonate. Elements sensitive to electron beam irradiation should be determined first. In addition, silicate minerals are preferred as standards rather than carbonate minerals. 展开更多
关键词 CARBONATE minerals:electron probe MICROANALYSIS characteristic X-ray TIME-DEPENDENT intensity BEAM current BEAM DIAMETER
单电子晶体管探针的电荷检测机制
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作者 苏丽娜 李文佳 任舰 《微纳电子技术》 北大核心 2019年第6期429-434,共6页
单电子晶体管(SET)具有极高的电荷灵敏度,是一种超灵敏电荷计。在先前工作的基础上,首先建立了电荷检测的电路模型,该SET扫描探针系统将SET器件集成制备在探针针尖上。然后利用从已制备的SET探针系统中提取的器件参数,模拟研究了该探针... 单电子晶体管(SET)具有极高的电荷灵敏度,是一种超灵敏电荷计。在先前工作的基础上,首先建立了电荷检测的电路模型,该SET扫描探针系统将SET器件集成制备在探针针尖上。然后利用从已制备的SET探针系统中提取的器件参数,模拟研究了该探针系统对直流偏置的量子点(QD)进行电荷检测的过程,分析了探针系统的耦合系数、电压灵敏度及空间分辨率等性能参数。模拟结果表明,随着探测距离的增加,探针的电导响应减弱。该SET探针系统的电压灵敏度高达10-6 V/Hz1/2、空间分辨率大于100 nm。通过模拟,最终获得了该探针系统的量子点的二维电势分布图。 展开更多
关键词 单电子晶体管(SET) 探针 电荷计 电荷检测 静电耦合
荧光量子点功能材料在生物医学领域的应用 预览
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作者 俞锴 《医疗装备》 2019年第11期193-195,共3页
荧光量子点功能材料作为一种用于生物示踪的新兴纳米材料,已广泛应用于生物医学研究领域。现介绍了荧光量子点功能材料的基本原理、特点及合成修饰方法,并着重阐述了荧光量子点功能材料在生物大分子和亚细胞结构、生物细胞和生物组织以... 荧光量子点功能材料作为一种用于生物示踪的新兴纳米材料,已广泛应用于生物医学研究领域。现介绍了荧光量子点功能材料的基本原理、特点及合成修饰方法,并着重阐述了荧光量子点功能材料在生物大分子和亚细胞结构、生物细胞和生物组织以及生物体标记中的应用。最后对荧光量子点生物功能材料在生物医学研究领域的发展情况进行总结,指出该材料存在稳定性不足、荧光量子的产率低等诸多问题。但随着荧光量子点加工技术的不断进步,该材料发展前景光明。 展开更多
关键词 荧光标记 量子点功能材料 生物医学 探针
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涡流法检测轴承内圈滚道表面缺陷研究 预览
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作者 张凯胜 王欢 赵燕 《轴承》 北大核心 2019年第7期46-49,共4页
在采用半自动检测装置保证检测稳定性的前提下,对某型轴承内圈滚道表面人工伤对比试样进行测试,分析不同频率、检测速度、缺陷尺寸对检测结果的影响。结果表明:终磨滚道的Cr4Mo4V内圈适宜的检测频率为710~909 kHz,采用自动化工装检测时... 在采用半自动检测装置保证检测稳定性的前提下,对某型轴承内圈滚道表面人工伤对比试样进行测试,分析不同频率、检测速度、缺陷尺寸对检测结果的影响。结果表明:终磨滚道的Cr4Mo4V内圈适宜的检测频率为710~909 kHz,采用自动化工装检测时不受检测速度影响,缺陷长度及宽度增大时涡流检测幅值随之增大,缺陷深度增大时检测幅值和相位角均增大,可通过人工伤对比试样判定不同当量缺陷的深度。 展开更多
关键词 滚动轴承 缺陷 涡流 探头 套圈 滚道
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西门子控制系统在转盘轴承感应淬火中的开发应用 预览
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作者 董振海 邹锦卫 郝丰林 《金属加工:热加工》 2019年第2期68-71,共4页
介绍西门子840D SL数控系统在风力发电行业转盘轴承感应淬火机床中的两个主要功能应用,系统PROBE功能和系统快速模拟量功能,以及如何实现跟踪功能的应用。
关键词 840D SL PROBE 系统快速模拟量功能应用 热处理
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Modification of NiCoCrAlY with Pt: Part Ⅰ. Effect of Pt depositing location and cyclic oxidation performance
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作者 Yingfei Yang Hongrui Yao +2 位作者 Zebin Bao Pan Ren Wei Li 《材料科学技术学报:英文版》 SCIE EI CAS CSCD 2019年第3期341-349,共9页
Pt layers of 5 μm in thickness were electroplated before or after depositing NiCoCrAlY coating by arc ion plating(AIP) aiming for identifying the effect of Pt enriching position on microstructure and cyclic oxidation... Pt layers of 5 μm in thickness were electroplated before or after depositing NiCoCrAlY coating by arc ion plating(AIP) aiming for identifying the effect of Pt enriching position on microstructure and cyclic oxidation behavior of Pt modified NiCoCrAlY coatings. Al-rich zones formed at the same position of Ptrich zones for both modified coatings due to uphill diffusion of Al driven by Pt. Cyclic oxidation tests at 1000 and 1100?C indicated that oxidation resistance of NiCoCrAlY was improved by Pt modification via different mechanisms: at surface, Pt-rich zone promoted selective oxidation of Al to form α-Al2O3,whilst at coating/substrate interface Pt-rich zone acted as effective diffusion barrier for titanium. Roles of Pt played in enhancing the oxidation performance of various Pt-modified NiCoCrAlY coating were investigated. 展开更多
关键词 CYCLIC OXIDATION Pt-modification NICOCRALY Electron probe micro-analysis(EPMA)
英语师范专业创新创业能力培养体系构建与实践探索——以淮南师范学院为例 预览
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作者 张久全 孟焱 《淮南师范学院学报》 2019年第3期127-130,共4页
英语师范专业改革亟需加强学生创新创业能力培养体系建设和实践路径探索。以淮南师范学院英语师范专业综合改革和成效为研究基础,建设“以能力为出发点、以课程为切入点、以平台为支撑点”的创新创业能力培养体系,英语师范专业的教学质... 英语师范专业改革亟需加强学生创新创业能力培养体系建设和实践路径探索。以淮南师范学院英语师范专业综合改革和成效为研究基础,建设“以能力为出发点、以课程为切入点、以平台为支撑点”的创新创业能力培养体系,英语师范专业的教学质量和人才培养质量得到了卓越化和创新化发展。同时,不断摸索“第一课堂”和“第二课堂”的实践路径,改革传统的“重教学,轻实践”“重专业,轻创新”的旧模式,致力于强化英语师范生的创新创业能力培养。 展开更多
关键词 英语师范专业 创新创业能力 培养体系 实践路径 探索
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海上油气田FGS与CCTV系统联动的研究及应用 预览
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作者 周鲁尧 艾如科 《石化技术》 CAS 2019年第7期43-43,76共2页
介绍了海上油气田火气系统与视频监控系统的组成和作用,结合实际工作经验分析提出了存在的问题,并针对该问题阐述了火气系统与视频监控系统联动改造的研究目标和实现方法。改造应用效果良好,具有较高的推广价值。
关键词 海上油气田 FGS CCTV 监控 探头 联动
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A SENSE OF MISSION 预览
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作者 Wang Hairong 《中国东盟报道》 2019年第2期30-32,共3页
On aerospace engineer Wen Bo’s cellphone are four identical photos of herself against the same backdrop taken at four different junctures marking milestones in her career and China’s lunar probe program.
关键词 identical PHOTOS SAME backdrop LUNAR PROBE
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探针技术在OTT TV质量监测系统中的应用 预览
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作者 李天校 《中国有线电视》 2019年第1期45-49,共5页
OTT(Over The Top)是一种通过公共互联网面向电视机传输的由广播电视机构提供视频内容的可管可控服务,其接收终端为智能电视(Smart TV)或者OTT盒子。"三网融合"使得电信和广电基础网络面貌一新,遍及接入、边缘和核心网,广电... OTT(Over The Top)是一种通过公共互联网面向电视机传输的由广播电视机构提供视频内容的可管可控服务,其接收终端为智能电视(Smart TV)或者OTT盒子。"三网融合"使得电信和广电基础网络面貌一新,遍及接入、边缘和核心网,广电行业有线电视数字化整体转换工作已基本完成,DVB+OTT融合是其发展的重要方向,广电运营商需要加快双向网络的改造,大力提供丰富多彩的互动业务,例如VOD、OTT TV、增值应用业务等。视频服务器、IP网络QoS指标和用户体验QoE质量是"三网融合"新业务保证的关键所在。根据安全播出监控和质量保障系统的设计要求,结合广州有线OTT视频业务质量监测系统的部署实例,为实现OTT视频播出质量的监管,提供优秀的视频质量监测服务,通过在前端部署EVA接入探针,对信号源进行实时监测和分析,在智能机顶盒中内嵌QoS Agent实现对用户无干扰式的IP视频业务质量管理、优化和故障排查。通过该监控系统可以实现对OTT TV视频业务的高效运维和业务监控,所有设备应具有广播级技术指标,保证24小时的安全播出。 展开更多
关键词 探针 OTT TV 质量监测
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Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications
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作者 Jingjing Cui Yuhua Yao +3 位作者 Cong Chen Rui Huang Weibing Zhang Junhong Qian 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第5期1071-1074,共4页
Two fluorescent“off-on”probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity.Both probes have two emission bands:The peak of shorter wavelength was sensitive to the polarity,while ... Two fluorescent“off-on”probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity.Both probes have two emission bands:The peak of shorter wavelength was sensitive to the polarity,while that in longer wavelength region was sensitive to the viscosity,which enables us to detect medium polarity and viscosity simultaneously.The lg(Ishort/Ilong)of YYH1 exhibited linear relationship to the solvent polarity,while that of YYH2 was closely related to the solvent viscosity.Furthermore,both probes showed potential in bioimaging mitochondrial polarity or viscosity in living cells. 展开更多
关键词 FLUORESCENT probe MITOCHONDRIA MICROVISCOSITY Micropolarity
Ru(Ⅱ) Bipyridyl Complex and TiO2 Nanocomposite Based Biomolecule-free Photoelectrochemical Sensor for Highly Selective Determination of Ultra-trace Hg^2+ in Aqueous Systems
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作者 WU Shuo YANG Xinlan ZHAO Yanqiu 《高等学校化学研究:英文版》 SCIE CAS CSCD 2019年第3期370-376,共7页
A biomolecule-free photoelectrochemical(PEC) probe(denoted as Ru-1) was designed, synthesized and coupled with TiO2 nanoparticles(NPs) for the highly sensitive and selective PEC detection of Hg^2+, a model analyte wit... A biomolecule-free photoelectrochemical(PEC) probe(denoted as Ru-1) was designed, synthesized and coupled with TiO2 nanoparticles(NPs) for the highly sensitive and selective PEC detection of Hg^2+, a model analyte with hypertoxicity to both human health and ecosystem. The probe Ru-1 was designed with Ru(Ⅱ) bipyridyl complex as the chromophore, thiocyanate ligand as the recognition unit, and carboxylate group as the linkage site to connect Ru-1 to TiO2 nanoparticles. Under irradiation, Ru-1 shows strong affinity to TiO2 and good photophysical properties of strong visible light absorption, slow electron-hole(e-h^+) recombination, and fast photoelectron injection to TiO2 nanoparticles via the bridge of 4-(2,2-bipyridin)-4-yl-thiophene moiety. However, the specific coordination of Hg^2+ with Ru-1 via the thiol moiety in the thiocyanate enlarges the band gap of tlie complex and reduces the photocurrent significantly. The synergistic interaction between TiO2 nanoparticles and the Ru-1 complex led to a selective PEC sensing strategy for Hg^2+ detection. Detectable linear ranges from 10^-12 g/mL to 10^-7 g/mL and from 10^-7g/mL to 10^-3 g/mL were obtained without the interference from possibly co-existed metal ions. The good analytical performances indicate the chemical probe based biomolecule-free PEC platform may offer a new route for the detection of biologically and environmentally important small molecules. 展开更多
关键词 Photoelectrochemical probe Ru(II) BIPYRIDYL COMPLEX Hg2+ detection NANOCOMPOSITE
基于TaqMan PCR鉴定猪源性成分的引物和探针研发 预览
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作者 郭梁 李春冬 +1 位作者 徐伟良 郭元晟 《浙江农业学报》 CSCD 北大核心 2019年第1期74-79,共6页
为了研发具有自主知识产权的猪源性成分检测的引物和探针,比对猪、牛、羊、马、鸡、鸭、兔、鹅等8种动物的线粒体基因组,筛选并设计猪特异性的引物和探针组合进行荧光定量PCR。研究结果表明,所研发的猪源性成分检测的引物和探针仅对猪相... 为了研发具有自主知识产权的猪源性成分检测的引物和探针,比对猪、牛、羊、马、鸡、鸭、兔、鹅等8种动物的线粒体基因组,筛选并设计猪特异性的引物和探针组合进行荧光定量PCR。研究结果表明,所研发的猪源性成分检测的引物和探针仅对猪相关DNA模板有典型扩增曲线,对其他动物来源的DNA模板无扩增,具有高度的猪源性特异性。灵敏度实验表明,利用此引物和探针的检测方法具有高度的灵敏度,可达1 pg级。肉制品中猪源性定量检测实验说明此方法具有较好的定量检测能力。此引物和探针组合适用于猪源性食品和农畜产品的检验检测。 展开更多
关键词 猪源性成分 引物 探针 TAQ MAN PCR
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A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells
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作者 Houna Duan Yu Ding +3 位作者 Chusen Huang Weiping Zhu Rui Wang Yufang Xu 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第1期55-57,共3页
Zinc plays a significant role in oxidative balance and central nervous systems. Herein, we reported a highly sensitive fluorescent probe DR, bearing a morpholine group and a BPEN ligand in the naphthalimide fluorophor... Zinc plays a significant role in oxidative balance and central nervous systems. Herein, we reported a highly sensitive fluorescent probe DR, bearing a morpholine group and a BPEN ligand in the naphthalimide fluorophore. Upon Zn2+binding, DR exhibited remarkable fluorescence enhancement, and showed high sensitivity to Zn2+with the association constant of 4.9 ? 108 L/mol, and the detection limit of15 nmol/L. Confocal imaging experiments indicated that DR was able to localize to lysosomes in MCF-7 cells. Moreover, upon H2 O2 stimulation in SH-SY5 Y cells, endogenous release of Zn2+was observed. 展开更多
关键词 NAPHTHALIMIDE ZINC ions Cellular IMAGING LYSOSOME Fluorescent probe
大厚度奥氏体不锈钢焊缝的超声探头设计 预览
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作者 胡华勇 张洪 张郁 《科技视界》 2019年第13期22-24,共3页
奥氏体不锈钢在工业中应用广泛,但其在焊接过程中容易产生缺陷,这些缺陷会导致事故的发生。超声检测可以有效地检测出焊缝中的缺陷,但由于奥氏体的晶粒尺寸粗大,会导致缺陷信号被噪声掩盖。针对此问题,本文设计了一组适用于大厚度奥氏... 奥氏体不锈钢在工业中应用广泛,但其在焊接过程中容易产生缺陷,这些缺陷会导致事故的发生。超声检测可以有效地检测出焊缝中的缺陷,但由于奥氏体的晶粒尺寸粗大,会导致缺陷信号被噪声掩盖。针对此问题,本文设计了一组适用于大厚度奥氏体焊缝检测的超声探头,最终提高了检测结果的可信度。 展开更多
关键词 奥氏体 焊缝 超声 探头
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Understanding formation of Mg-depletion zones in Al-Mg alloys under high pressure torsion
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作者 Jing Xue Shenbao Jin +3 位作者 Xianghai An Xiaozhou Liao Jiehua Li Gang Sha 《材料科学技术学报:英文版》 SCIE EI CAS CSCD 2019年第5期858-864,共7页
Redistribution of elements may take place in alloys during severe plastic deformation, which significantly alters the mechanical properties of the alloys. Therefore, comprehensive knowledge about deformationinduced re... Redistribution of elements may take place in alloys during severe plastic deformation, which significantly alters the mechanical properties of the alloys. Therefore, comprehensive knowledge about deformationinduced redistribution of elements has to be established. In the present paper, the distribution of Mg in an Al-Mg alloy processed by high pressure torsion was examined using atom probe tomography(APT).With crystallographic information extracted by APT data analysis, this research reveals that the movement of dislocations plays an important role in the formation of Mg-depletion zones in the deformed microstructure. 展开更多
关键词 High-pressure TORSION ATOM probe TOMOGRAPHY Aluminum alloys GRAIN boundary diffusion DISLOCATION
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