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Effect Evaluation of Strychnos nux-vomica L.with Integrative Methods for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma Patients:A Self-Controlled Clinical Trial 认领
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作者 DAI Tie-ying CHEN Chu-chu +6 位作者 HONG Li-li Ge Hang-ping PEI Jun LYU Wen-qi YANG Xue SHEN Jian-ping HU Zhi-ping 《中国结合医学杂志:英文版》 SCIE CAS 2021年第2期131-136,共6页
Objective:To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy(BIPN)of patients with multiple myeloma(MM).Methods:A total of 19 MM patients with BIPN... Objective:To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy(BIPN)of patients with multiple myeloma(MM).Methods:A total of 19 MM patients with BIPN were enrolled and Nux Vomica Capsule(NVC,0.4 g,thrice daily)were orally administrated for 30 days.Comparative analysis on parameters between pre-and post-therapy,including peripheral neuropathy(PN)grade,neurotoxicity score,Chinese medicine(CM)syndrome score,total neuropathy score(TNS),coagulation function,and serum nerve growth factor(NGF)levels were conducted.The adverse events were monitored.Results:In BIPN of MM patients who received NVC,PN grade was lowered,neurotoxicity score was obviously decreased(P 0.01),and both CM syndrome score and TNS were remarkably decreased(P<0.01).After the therapy,activated partial thromboplastin time was prolonged(P<0.01)and fibrinogen was declined(P<0.05),showing improvement in the hypercoagulable state of patients.No significant difference of NGF recovery degrees was detected between pre-and post-therapy(P>0.05).No evident adverse reactions were observed during the course of treatment.Conclusion:Strychnos nux-vomica L.has significantly effect with a good safety in treatment of BIPN in MM patients. 展开更多
关键词 bortezomib-induced peripheral neuropathy grilled nux vomica total neuropathy score Chinese medicine syndrome score nerve growth factor
老年2型糖尿病患者并发周围神经病变的危险因素分析 认领
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作者 王晓林 《黑龙江医学》 2021年第1期19-21,共3页
目的:分析老年2型糖尿病患者并发周围神经病变(DPN)的危险因素,为临床实施预防措施提供参考。方法:选取南阳市宛城区第一人民医院2018年9月-2019年12月就诊104例老年2型糖尿病患者为研究对象,依据DPN诊断标准将所有患者分为并发DPN组与... 目的:分析老年2型糖尿病患者并发周围神经病变(DPN)的危险因素,为临床实施预防措施提供参考。方法:选取南阳市宛城区第一人民医院2018年9月-2019年12月就诊104例老年2型糖尿病患者为研究对象,依据DPN诊断标准将所有患者分为并发DPN组与对照组,统计两组一般资料,如年龄、性别、病程、有无长期吸烟史等,并对其进行实验室检查,分析两组上述指标差异性,指出可能导致年2型糖尿病患者并发DPN的危险因素。结果:入选104例老年2型糖尿病患者中,42例并发DPN,占40.38%。并发DPN组在年龄、性别方面与对照组相比,差异无统计学意义(P>0.05);并发DPN组在病程、有无长期吸烟史、糖化血红蛋白(HbA1C)、HOMA-β方面与对照组相比,差异有统计学意义(P<0.05);经多项非条件logistic回归分析检验结果显示,病程≥5年、长期吸烟史、HbA1C水平升高、HOMA-β降低可能是导致老年2型糖尿病患者并发DPN的危险因素(OR>1,P<0.05)。结论:病程≥5年、长期吸烟史、HbA1C水平升高、HOMA-β降低可能是导致老年2型糖尿病患者并发DPN的危险因素,临床需积极做好预防措施,以期降低DPN发生率。 展开更多
关键词 老年2型糖尿病 周围神经病 危险因素
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社区延续性护理管理现状及发展 认领
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作者 别敏娟 陈红宇 《中国社区医师》 2021年第2期6-7,共2页
对补充和替代医学的概念及应用效果进行综述,了解补充和替代医学在化疗所致周围神经病变(CINP)中的干预应用现状,总结应用于化疗所致周围神经毒性的常见防治措施,为CINP患者提供相关的护理指导。
关键词 补充和替代医学 周围神经病变 化疗
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中国人群2型糖尿病周围神经病变危险因素的系统评价 认领
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作者 秦明 宋玉玲 +1 位作者 张亭 刘长梅 《中国当代医药》 2021年第1期20-26,共7页
目的通过系统评价探讨中国人群2型糖尿病周围神经病变相关危险因素。方法计算机系统检索PubMed、EMbase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)和万方科技期刊全文数据库(WanFang)中的中国人... 目的通过系统评价探讨中国人群2型糖尿病周围神经病变相关危险因素。方法计算机系统检索PubMed、EMbase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)和万方科技期刊全文数据库(WanFang)中的中国人群2型糖尿病周围神经病变危险因素的相关研究,检索时间限定为2000年1月~2020年2月,同时补充检索纳入文献的参考文献。由两名评价者根据纳入、排除标准进行独立选择文献、提取资料、评价质量后,采用Rev Man 5.3软件进行系统评价,用固定效应模型或随机效应模型合并OR值及95%可信区间(CI)分析各个相关危险因素,采用敏感性分析评估结果的稳定性,用漏斗图评估文献的发表偏倚。结果共纳入文献12篇,总样本量为7886例。纳入分析的危险因素共10个,分别为年龄、糖化血红蛋白、糖尿病病程、空腹血糖、餐后2 h血糖、收缩压、舒张压、总胆固醇、三酰甘油、体重指数。结果显示,年龄、糖尿病病程、糖化血红蛋白、空腹血糖是影响糖尿病周围神经病变发生的危险因素。结论初步确定年龄、糖尿病病程、糖化血红蛋白、空腹血糖是影响糖尿病周围神经病变发生的重要独立危险因素,为临床上糖尿病周围神经病变发生的早期防预提供重要依据。 展开更多
关键词 2型糖尿病 中国人群 周围神经病变 危险因素 系统评价
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Treatment of Chronic Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review 认领
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作者 Alda Tavares Ana Agrelo Manuela Machado 《癌症治疗(英文)》 2020年第9期519-534,共16页
<strong>Introduction:</strong> <span style="font-family:Verdana;">Oxaliplatin is a platinum-derivative chemotherapeutic agent used in digestive tumours, in the adjuvant and metastatic setti... <strong>Introduction:</strong> <span style="font-family:Verdana;">Oxaliplatin is a platinum-derivative chemotherapeutic agent used in digestive tumours, in the adjuvant and metastatic setting. Oxaliplatin can cause a chronic peripheral sensory neuropathy which impacts</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">the quality of life and is dose limiting. To date, no therapeutic strategies have proved effective in the treatment of oxaliplatin-induced peripheral neuropathy (OIPN). </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A computerized search of the literature on PubMed database was performed. Publisher original articles were included if they focused on treatment of peripheral neuropathy among patients submitted to oxaliplatin. Eleven out of 242 reviewed papers met our inclusion criteria and were subjected to a 19-item quality checklist. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The included studies differed with respect to study design, patient population and sample size, neuropathic symptoms assessment and efficacy measure. Most studies had an</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">adequate quality. Ten trials tested one drug, and one pilot study tested a non-pharmacological treatment</span><span style="font-family:Verdana;">—</span><span style="font-family:Verdana;">the neurofeedback. Of these, 3 trials included only patients submitted to oxaliplatin-based chemotherapy. Duloxetine showed moderate efficacy in 3 trials. Topical treatment with capsaicin or 10% amitriptyline was promisors in 2 single-arm trials with a </span><span style="font-family:Verdana;">few </span><span style="font-family:Verdana;">sample</span><span style="font-family:Verdana;">s</span><span style="font-family:;" "=""><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Conclusion 展开更多
关键词 Peripheral Neuropathy OXALIPLATIN Chemotherapy-Induced Peripheral Neuropathy PAIN NEUROTOXICITY Supportive Care
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Current and future applications of ultrasound imaging in peripheral nerve disorders 认领
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作者 Antonia S Carroll Neil G Simon 《世界放射学杂志:英文版(电子版)》 CAS 2020年第6期101-129,共29页
Neuromuscular ultrasound(NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment o... Neuromuscular ultrasound(NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both diagnostic and management pathways in peripheral nerve disorders. This review describes the current and future techniques used in NMUS and details the applications and developments in the diagnosis and monitoring of compressive, hereditary, immune-mediated and axonal peripheral nerve disorders, and motor neuron diseases. Technological advances have allowed the increased utilisation of ultrasound for management of peripheral nerve disorders;however, several practical considerations need to be taken into account to facilitate the widespread uptake of this technique. 展开更多
关键词 Neuromuscular ultrasound Peripheral neuropathy POLYNEUROPATHY Entrapment neuropathy Immune-mediated neuropathy Hereditary neuropathy
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Peripheral Neuropathy under Infliximab Therapy: About One Case 认领
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作者 Fatima-Zahra Hamdoun Hakima Abid +4 位作者 Nada Lahmidani Mounia El Yousfi Dafr-Allah Benajah Mohammed El Abkari Adil Ibrahimi 《肠胃病学期刊(英文)》 2020年第9期242-246,共5页
<span style="font-family:Verdana;">A-TNF inhibitors are increasingly used in various inflammatory disorders. Multiple side effects have been reported in recent years, particularly peripheral neuropathi... <span style="font-family:Verdana;">A-TNF inhibitors are increasingly used in various inflammatory disorders. Multiple side effects have been reported in recent years, particularly peripheral neuropathies. We report a case of axonal neuropathy occurring after the start of treatment with Infliximab. This is a 47 years old patient, followed for Crohn</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s disease requiring treatment with Infliximab. Twenty-two weeks later, the patient presented a grade 4 of axonal neuropathy. We concluded to a medicinal sensitive neuropathy after elimination of other etiologies.</span><span style="font-family:""> </span><span style="font-family:Verdana;">Given the severity of the neurological symptoms, we decided to change the therapeutic class. 展开更多
关键词 Crohn’s Disease INFLIXIMAB Peripheral Neuropathy
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Factors Associated with Occurrence of Peripheral Neuropathy among HIV/AIDS Clients at Kombewa Sub County Hospital of Kisumu County, Kenya 认领
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作者 Damian Otieno Opemo 《护理学期刊(英文)》 2020年第7期665-675,共11页
Peripheral Neuropathy (PN) commonly arises as HIV related nerve complication. The study made attempts to assess the underlying factors leading to peripheral neuropathy, the disabling effects of peripheral neuropathy o... Peripheral Neuropathy (PN) commonly arises as HIV related nerve complication. The study made attempts to assess the underlying factors leading to peripheral neuropathy, the disabling effects of peripheral neuropathy on a patient’s life quality and measures which can be implemented to prevent or lessen the burdening effects of these neuropathies. A descriptive design was adopted where cross-sectional data targeting a sample of 100 consenting adult HIV/AIDS clients were collected utilizing structured questionnaires as key instruments of data collection. In this study variables such as age, height, the past and current CD4 lymphocytes, the viral load, the average duration of antiretroviral treatment (ART), use and the presence of certain co-infection, diabetes or alcohol abuse were analyzed to determine their effects of occurrence of peripheral neuropathy. Fifty eight percent (58%) of the clients were classified to be having neuropathic as compared 42% who did not have neuropathic pain. Duration of diagnosis with HIV and previous CD4 count did not significantly determine the occurrence of neuropathic pain. Viral load at time of diagnosis with HIV;nutritional uptake and HAART regimen significantly contribute to occurrence of PN among HIV/AIDS clients. There was no significant association between cases of peripheral neuropathy and demographic factors such as age, gender, height of the respondents and level of education. Clients with peripheral neuropathy were not receiving adequate health talks on peripheral neuropathy. Effect of PN on physical activity was observed. There is need for providing both medical and palliative treatment to HIV/AIDS patients suffering from peripheral neuropathy. 展开更多
关键词 Peripheral Neuropathy HIV/AIDS Kenya
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高频超声与剪切波弹性成像结合临床指标评估糖尿病患者胫神经病变风险 认领
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作者 孙冉 梁丹艳 +2 位作者 吴国柱 刘倩 红华 《临床超声医学杂志》 CSCD 2020年第3期189-193,共5页
目的探讨高频超声与剪切波弹性成像结合临床指标评估2型糖尿病周围神经病变患者胫神经病变风险的临床应用价值。方法选取我院糖尿病患者72例,其中周围神经病变患者34例(DPN组),无周围神经病变患者38例(NDPN组),比较两组患者性别、年龄... 目的探讨高频超声与剪切波弹性成像结合临床指标评估2型糖尿病周围神经病变患者胫神经病变风险的临床应用价值。方法选取我院糖尿病患者72例,其中周围神经病变患者34例(DPN组),无周围神经病变患者38例(NDPN组),比较两组患者性别、年龄、病程、体质量指数(BMI)、同型半胱氨酸(Hcy)、胰岛素样生长因子-1(IGF-1)、糖化血红蛋白(HbA1c),以及高频超声所测参数胫神经的左右径、前后径、横截面积(CSA)及剪切波弹性成像所测弹性模量值;分析超声参数与实验室指标的相关性;对临床资料、实验室指标、超声参数进行多因素分析,并对结果进行量化评分。结果DPN组患者的年龄、病程均高于NDPN组(均P<0.05),性别、BMI差异无统计学意义;DPN组胫神经左右径、前后径、CSA、弹性模量值、HbA1c、Hcy均高于NDPN组,IGF-1低于NDPN组,差异均有统计学意义(均P<0.05);胫神经左右径与Hcy、HbA1c呈正相关(r=0.339、0.288,均P<0.05);前后径与IGF-1呈负相关(r=-0.406,P<0.05);CSA与Hcy、HbA1c呈正相关(r=0.351、0.257,均P<0.05),与IGF-1呈负相关(r=-0.334,P<0.05);弹性模量值与Hcy、HbA1c呈正相关(r=0.246、0.192,均P<0.05)。多因素分析结果显示,病程、CSA、弹性模量值、HbA1c是DPN的独立危险因素(OR=3.267、1.925、1.117、3.542,均P<0.05),而IGF-1是保护因素(OR=0.892,P=0.004);列线图结果显示评分达180分,周围神经病变的风险达70%。结论高频超声与剪切波弹性成像结合临床指标可评估糖尿病周围神经病变患者胫神经病变风险,其中病程、CSA、弹性模量值及HbA1c的增高是评估糖尿病周围神经病变患者胫神经病变的独立危险因素,而IGF-1增高是保护因素。 展开更多
关键词 超声检查 高频 剪切波弹性成像 周围神经病变 糖尿病 胫神经病变 IGF-1 HBA1C Hcy
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Potential use of corneal confocal microscopy in the diagnosis of Parkinson's disease associated neuropathy 认领
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作者 Ning-Ning Che Hong-Qi Yang 《转化神经变性病(英文)》 SCIE CAS 2020年第3期344-353,共10页
Parkinson's disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of 65.In recent years,Parkinson's research has mainly focused on motor and non-motor ... Parkinson's disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of 65.In recent years,Parkinson's research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls.Corneal confocal microscopy(CCM)is a real-time,non-invasive,in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders.CCM has shown significantly lower corneal nerve fiber density(CNFD)in patients with PD compared to healthy controls.Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD.This review provides an overview of the ability of CCM to detect nerve damage associated with PD. 展开更多
关键词 Parkinson's disease Peripheral neuropathy Corneal confocal microscopy Small fiber neuropathy
多伦多临床神经病变评分在2型糖尿病周围神经病变筛查中的应用及对临床治疗的评价 认领 被引量:2
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作者 杨曼 李奕平 +1 位作者 杨莹 毛文文 《昆明医科大学学报》 CAS 2020年第5期75-79,共5页
目的分析多伦多临床神经病变评分在2型糖尿病周围神经病变筛查中的应用及对临床治疗评价作用。方法选取2018年1月至2019年3月昆明医科大学第四附属医院收治的120例2型糖尿病患者,以多伦多临床神经病变评分量表(toronto clinical scoring... 目的分析多伦多临床神经病变评分在2型糖尿病周围神经病变筛查中的应用及对临床治疗评价作用。方法选取2018年1月至2019年3月昆明医科大学第四附属医院收治的120例2型糖尿病患者,以多伦多临床神经病变评分量表(toronto clinical scoring system,TCSS)进行糖尿病周围神经病变(diabetic peripheral neuropathies,DPN)筛查,同时行神经肌电图检查,进行对比;随后将TCSS评分在6~19分的患者按照电脑随机法分为观察组和对照组,对照组以维生素B12结合前列地尔进行治疗,观察组则采用硫辛酸结合前列地尔进行治疗。对比TCSS筛查符合率、两组治疗前后TCSS评分变化并分析TCSS对评价DPN治疗的作用和价值。结果120例患者完成TCSS评分时间平均为(11.25±1.48)min,其中≤5分占比41.67%,6~19分占比58.33%;神经肌电图检查阳性率为63.33%;两种方法筛查符合率对比,差异无统计学意义(P>0.05);TCSS评分在6~19分的患者分为观察组和对照组,两组治疗前DPN分级对比,差异无统计学意义(P>0.05),观察组治疗后DPN(-)较治疗前比率明显升高而DPN(+++)较治疗前比率明显降低(P<0.0.5),观察组治疗后DPN(-)比率高于对照组而DPN(+++)低于对照组(P<0.05);两组治疗前TCSS评分对比,差异无统计学意义(P>0.05),两组治疗后TCSS评分相较于治疗前明显降低(P<0.05),观察组治疗后TCSS评分低于对照组(P<0.05)。结论将TCSS评分用于2型糖尿病周围神经病变筛查中效果良好,能够作为筛查DPN的工具;且使用TCSS评分可以对临床治疗方案和效果进行评价,具有良好的推广应用价值。 展开更多
关键词 多伦多临床神经病变评分量表 2型糖尿病 周围神经病变
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Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Peripheral Nerve Injury:A Case Report 认领
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作者 Fangjie Huang Shimei Zhou +4 位作者 Mangsuo Zhao Jing Wang Jingfen Huang HongzhiGuan Liyan Qiao 《医学科学进展杂志(英文)》 2020年第2期12-16,共5页
A patient with Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis presented with quadriplegia and multiple peripheral neuropathy with axonal lesion,confirmed by electrophysiological examination.The muscle strength ... A patient with Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis presented with quadriplegia and multiple peripheral neuropathy with axonal lesion,confirmed by electrophysiological examination.The muscle strength in the limbs of the patient gradually recovered almost completely,accompanied by the reversal of neuroelectrophysiological symptoms,and the improvement of clinical manifestations,including consciousness,respiration and cognitive function.It was revealed that the neuropathy in NMDAR encephalitis involved motor or sensorimotor nerves more than pure sensory nerves.No autoantibodies were detectable,in contrast to other anti-NMDAR overlapping syndromes.Although the underlying mechanism remains unclear,it may be associated with autoimmune generalization.In conclusion,when patients with NMDAR encephalitis present with severe limb paralysis,the possibility of peripheral nerve damage should be considered. 展开更多
关键词 Anti-NMDAR encephalitis Peripheral nerve disease Multiple peripheral neuropathy Autoimmune generalization Overlapping syndrome
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糖尿病足发病机制研究进展 认领
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作者 何元旭 何志军 +2 位作者 刘涛 陈梓瑜 王海刚 《河南中医》 2020年第10期1614-1617,共4页
糖尿病足的发病机制较为复杂,多种损伤机制相互作用,目前研究公认的发病机制有周围血管病变、周围神经病变以及在周围神经血管病变基础上的感染,其他发病机制如:氧化应激、相关通路、基因遗传等。针对糖尿病足,相关学者依据中医学理论... 糖尿病足的发病机制较为复杂,多种损伤机制相互作用,目前研究公认的发病机制有周围血管病变、周围神经病变以及在周围神经血管病变基础上的感染,其他发病机制如:氧化应激、相关通路、基因遗传等。针对糖尿病足,相关学者依据中医学理论提出多种病机学说,可用于指导临床辨证施治,首先络病学说与周围血管病变关系密切,其中感染又可归之于外毒侵袭,毒损脉络;其次玄府理论与周围神经病变又有相通之处,脏腑学说贯穿疾病发展始终。今后,在治疗过程中能够更好地发挥中医与西医各自的优势,提高糖尿病足的治疗水平。 展开更多
关键词 糖尿病足 中医病机 发病机制 络病学说 玄府理论 脏腑学说 周围血管疾病 周围神经病变 感染
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加味黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变患者的临床疗效 认领
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作者 陈强 吕美娟 《中国药物经济学》 2020年第3期63-66,共4页
目的探讨加味黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变(DPN)患者的临床疗效。方法选取2019年3—9月辽宁中医药大学附属医院收治的100例DPN患者作为研究对象,利用随机分配法将其分为对照组和观察组,每组50例。对照组患者在常规治疗... 目的探讨加味黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变(DPN)患者的临床疗效。方法选取2019年3—9月辽宁中医药大学附属医院收治的100例DPN患者作为研究对象,利用随机分配法将其分为对照组和观察组,每组50例。对照组患者在常规治疗(控制血糖、饮食指导、运动处方建立)基础上采用硫辛酸注射液治疗,观察组在对照组西医治疗基础上予以加味黄芪桂枝五物汤口服。比较两组患者治疗前后中医主症积分、一氧化氮(NO)、前列环素(PGI2)、多伦多临床评分系统(TCSS)评分、密西根神经病变筛选表(MNSI)评分变化情况。结果治疗后,两组中医主症评分、NO及PGI2表达水平、TCSS评分、MNSI评分有所改善,且观察组明显优于对照组,差异有统计学意义(P<0.05)。结论在西医常规治疗基础上采用加味黄芪桂枝五物汤治疗DPN,可有效改善患者微循环,改善肢体麻凉、疼痛等症状,减轻患者痛苦。 展开更多
关键词 糖尿病 周围神经病变 阳虚血瘀 中西医结合 微循环
名老中医赵继福教授治疗糖尿病周围神经病变辨治思路探析 认领
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作者 包扬 徐凯 +4 位作者 李志浩 赵书彬 胥玲 惠严夕 赵继福 《中国中医药现代远程教育》 2020年第13期51-52,共2页
糖尿病周围神经病变归属于中医"消渴""痹病"范畴,是消渴病的慢性并发症之一。赵继福教授通过对消渴病病变进展的深入研究,指出糖尿病周围神经病变多发生于消渴病虚损阶段,并根据临床症状与病因病机特点,提出以益气... 糖尿病周围神经病变归属于中医"消渴""痹病"范畴,是消渴病的慢性并发症之一。赵继福教授通过对消渴病病变进展的深入研究,指出糖尿病周围神经病变多发生于消渴病虚损阶段,并根据临床症状与病因病机特点,提出以益气温阳通络法治疗本病,临床疗效显著。 展开更多
关键词 益气温阳通络法 糖尿病 周围神经病变 辨治思路 消渴 脉痹
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Effects of Hirudin on High Glucose-Induced Oxidative Stress and Inflammatory Pathway in Rat Dorsal Root Ganglion Neurons 认领 被引量:1
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作者 LIU Wei LIANG Xiao-chun SHI Yue 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2020年第3期197-204,共8页
Objective:To investigate protective effects of hirudin on oxidative stress and apoptosis of spinal dorsal root ganglion cells in high-glucose rats at the cellular and molecular level.Methods:Dorsal root ganglion neuro... Objective:To investigate protective effects of hirudin on oxidative stress and apoptosis of spinal dorsal root ganglion cells in high-glucose rats at the cellular and molecular level.Methods:Dorsal root ganglion neurons(DRGn)were harvested from embryonic day in 15 SD rats,purified and identificated after primary culture.They were divided into the normal control group,high-glucose(HG)group,positive control(alpha-lipoic acid,ALA)group,low-dose hirudin group(H1),medium-dose hirudin group(H2)and high-dose hirudin group(H3).The control group was cultured by neuron specific culture medium,while the HG group was cultured by neuron specific culture medium and 20 mmol/L glucose(HG medium).The hirudin groups were cultured by HG medium+0.25 IU/mL hirudin(H1),HG medium+0.5 IU/mL hirudin(H2)and HG medium+1 IU/mL hirudin(H3).The ALA group was cultured by HG medium +100μmol/L ALA.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt etrazolium bromide(MTT)assay was used to explore the optimum concentration and intervention time.Flow cytometry assay was used to detect the level of reactive oxygen series(ROS).Western blot and quantificational realtime polymerase chain reaction(qRT-PCR)were used to detect the expression of protein and mRNA of nuclear factor erythroid 2-related factor 2(Nrf-2),hemeoxygence-1(HO-1),nuclear factor-κB(NF-κB)and Caspase-3.TUNEL assay was used to test the apoptosis rate of different groups.Results:After 24 h of culture,the cell activity of hirudin and ALA groups were higher than that of HG group,and there was a statistical difference between the H1 group and HG group(P<0.05).In hirudin groups,the apoptosis rate of cells,the expression of activated Caspase-3 protein and Caspase-3 mRNA were lower than those of HG group(P<0.01),higher than those of ALA group(P<0.01 or P<0.05).The ROS level of hirudin groups was higher than that of ALA group(P<0.01),lower than that of HG group(P<0.01 or P<0.05).The expression of NF-κB(P65)protein in H3 group were lower than those of HG group(P<0.05).The expression of Nrf-2 protein 展开更多
关键词 HIRUDIN DIABETIC peripheral NEUROPATHY oxidative stress apoptosis DORSAL root GANGLION NEURON
4例异烟肼致周围神经病患者的电生理特点及文献复习 认领
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作者 张铁英 李嫚 +3 位作者 常明则 张格娟 马娟 刘敏 《临床医学研究与实践》 2020年第2期3-4,共2页
目的探讨异烟肼所致周围神经病的临床特点及电生理改变。方法对4例异烟肼所致周围神经病患者的临床及电生理特点进行总结,并进行文献回顾性分析。结果周围神经病是异烟肼常见的不良反应,主要表现为痛性感觉过敏及感觉异常,以感觉神经受... 目的探讨异烟肼所致周围神经病的临床特点及电生理改变。方法对4例异烟肼所致周围神经病患者的临床及电生理特点进行总结,并进行文献回顾性分析。结果周围神经病是异烟肼常见的不良反应,主要表现为痛性感觉过敏及感觉异常,以感觉神经受累为主,严重者可累及运动神经,下肢重于上肢,神经传导速度测定呈现对称性感觉神经及运动神经动作电位波幅减低或消失,潜伏期及传导速度正常。电生理特点为对称性、长度依赖性轴索型感觉运动神经病。结论异烟肼可导致周围神经病损,神经电生理检查可作为早期诊断依据,早期呈可逆性,停药并辅以维生素B6治疗有效。 展开更多
关键词 异烟肼 周围神经病 电生理学 维生素B6
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住院2型糖尿病合并周围神经病变患者临床指标及肌电图特点分析 认领
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作者 刘湘 《中国社区医师》 2020年第17期37-38,共2页
目的:分析住院2型糖尿病合并周围神经病变患者临床指标和肌电图的特点。方法:2017年3月-2018年4月收治2型糖尿病患者114例,其中研究组57例为合并周围神经病变患者;对照组57例为未合并周围神经病变患者。两组患者均进行血压、生化检查以... 目的:分析住院2型糖尿病合并周围神经病变患者临床指标和肌电图的特点。方法:2017年3月-2018年4月收治2型糖尿病患者114例,其中研究组57例为合并周围神经病变患者;对照组57例为未合并周围神经病变患者。两组患者均进行血压、生化检查以及肌电图检查,对比检查结果。结果:两组患者收缩压、舒张压、空腹血糖、餐后2 h血糖、糖化血红蛋白等指标水平比较,差异无统计学意义(P>0.05);两组患者肌酐、尿酸、肾小球滤过率、血清胱抑素C(Cys-C)等指标水平比较,差异有统计学意义(P<0.05);两组患者肌电图各项数据水平比较,差异有统计学意义(P<0.05)。结论:2型糖尿病合并周围神经病变患者肌酐、尿酸、Cys-C水平均较高,肾小球滤过率低,肌电图为上下肢感觉神经、运动神经均出现一定损伤,具体为潜伏期过长,波幅出现下降,传导速度慢。 展开更多
关键词 2型糖尿病 周围神经病变 临床指标 肌电图
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艾灸对糖尿病周围神经病变肢体疼痛患者的疗效观察 认领
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作者 兰花兰 刘凤彬 廖秀娥 《中外医学研究》 2020年第9期169-171,共3页
目的:观察艾灸用于糖尿病周围神经病变肢体疼痛患者的疗效,为临床护理提供依据.方法:从福建中医药大学附属人民医院内分泌科抽取符合纳入标准的糖尿病周围神经病变肢体疼痛患者100例,并按就诊顺序分为试验组和对照组,各50例.对照组患者... 目的:观察艾灸用于糖尿病周围神经病变肢体疼痛患者的疗效,为临床护理提供依据.方法:从福建中医药大学附属人民医院内分泌科抽取符合纳入标准的糖尿病周围神经病变肢体疼痛患者100例,并按就诊顺序分为试验组和对照组,各50例.对照组患者给予常规护理;试验组患者在此基础上使用艾灸仪灸丰隆穴和足三里穴治疗.观察两组患者干预前后的空腹血糖、神经病变情况、疼痛情况.结果:干预后,两组空腹血糖值均较干预前下降(P<0.05),但干预后两组比较差异无统计学意义(P>0.05);试验组的多伦多临床神经病变评分(TCSS)、简易疼痛量表评分(VAS)低于对照组,差异均有统计学意义(P<0.05).结论:常规治疗护理结合多功能艾灸仪施灸可缓解糖尿病患者周围神经病变肢体疼痛的症状,提高患者的生活质量. 展开更多
关键词 周围神经病变 艾灸 肢体疼痛
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关注COVID-19合并周围神经病 认领
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作者 郭军红 蒲传强 《中华神经科杂志》 CAS CSCD 北大核心 2020年第11期865-867,共3页
突如其来的新型冠状病毒肺炎(COVID-19)大暴发尽管在我国已经被控制,但仍在全世界暴发和流行,死亡人数仍在不断增加。绝大多数的COVID-19确实是以肺部不同程度损伤为主,也是导致死亡的最主要原因,但是各个临床学科都在关注本系统是否有... 突如其来的新型冠状病毒肺炎(COVID-19)大暴发尽管在我国已经被控制,但仍在全世界暴发和流行,死亡人数仍在不断增加。绝大多数的COVID-19确实是以肺部不同程度损伤为主,也是导致死亡的最主要原因,但是各个临床学科都在关注本系统是否有重要的受损现象。神经内科同行更关注COVID-19是否直接或间接地累及神经系统。从我国8万多个病例看,所报道的资料中,真正并发神经系统受损的客观证据不多。而欧美自COVID-19大流行以来,报道了一些合并周围神经受累病例,值得同行们关注。 展开更多
关键词 新型冠状病毒肺炎 神经系统 周围神经病
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