Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Human-origin <i>Lactobacillus</i> is a preferable source of probiotic bacteria. This stud...Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Human-origin <i>Lactobacillus</i> is a preferable source of probiotic bacteria. This study screened 14 vaginal <i>Lactobacillus</i> strains as probiotic candidates by investigating probiotic-related cell surface characteristics including cell surface hydrophobicity (CSH), Lewis acidity/basicity, autoaggregation, and biofilm formation. Moderate to high CSH and autoaggregation, high basicity and low acidity were prevalent in the 14 tested strains. Biofilm formation varied in a large range among the 14 tested strains. CSH showed a high correlation with Lewis acidity and autoaggregation, while Lewis acidity was highly correlated with autoaggregation and biofilm formation. Four strains were selected as promising probiotic strains. This study was the first one to compare antibiotic sensitivity between biofilm-forming cells and planktonic cells of <i>Lactobacillus</i> species, and found that biofilm-forming cells of a <i>L. fermentum</i> strain had a significantly higher survival rate than planktonic cells in cefotaxime, cefmetazole and tetracycline, but were as sensitive to oxacillin and ampicillin as planktonic cells were.展开更多
The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with pro...The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity.This review highlights some of the important bioactive compounds and probiotic bacteria,suggesting them as a ray of hope in the milieu of the COVID-19 management.展开更多
目的用Meta分析的方式评价益生菌对急性肠胃炎疗效。方法通过检索中外文献库,提取文献中的数据,对益生菌对急性肠胃炎有效率,显效率,腹泻时间进行Meta分析并汇总。结果共计纳入11篇文献,1221例患者,分析显示益生菌在进行急性肠胃炎治疗...目的用Meta分析的方式评价益生菌对急性肠胃炎疗效。方法通过检索中外文献库,提取文献中的数据,对益生菌对急性肠胃炎有效率,显效率,腹泻时间进行Meta分析并汇总。结果共计纳入11篇文献,1221例患者,分析显示益生菌在进行急性肠胃炎治疗时的总体有效率的OR值为6.00,95%CI为(3.68,9.79),益生菌在进行急性肠胃炎治疗时的总体显效率的OR值为3.52,95%CI为(2.06,6.01),益生菌在进行急性肠胃炎治疗时降低腹泻时间的均属差(weighted mean difference,WMD)值为-0.79,95%CI为(-1.33,-0.24),且三项均有统计学意义。结论益生菌可以有效地治疗急性肠胃炎,建议临床上使用益生菌治疗急性肠胃炎。展开更多
Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which...Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary.展开更多
文摘Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Human-origin <i>Lactobacillus</i> is a preferable source of probiotic bacteria. This study screened 14 vaginal <i>Lactobacillus</i> strains as probiotic candidates by investigating probiotic-related cell surface characteristics including cell surface hydrophobicity (CSH), Lewis acidity/basicity, autoaggregation, and biofilm formation. Moderate to high CSH and autoaggregation, high basicity and low acidity were prevalent in the 14 tested strains. Biofilm formation varied in a large range among the 14 tested strains. CSH showed a high correlation with Lewis acidity and autoaggregation, while Lewis acidity was highly correlated with autoaggregation and biofilm formation. Four strains were selected as promising probiotic strains. This study was the first one to compare antibiotic sensitivity between biofilm-forming cells and planktonic cells of <i>Lactobacillus</i> species, and found that biofilm-forming cells of a <i>L. fermentum</i> strain had a significantly higher survival rate than planktonic cells in cefotaxime, cefmetazole and tetracycline, but were as sensitive to oxacillin and ampicillin as planktonic cells were.
文摘The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity.This review highlights some of the important bioactive compounds and probiotic bacteria,suggesting them as a ray of hope in the milieu of the COVID-19 management.
文摘目的用Meta分析的方式评价益生菌对急性肠胃炎疗效。方法通过检索中外文献库,提取文献中的数据,对益生菌对急性肠胃炎有效率,显效率,腹泻时间进行Meta分析并汇总。结果共计纳入11篇文献,1221例患者,分析显示益生菌在进行急性肠胃炎治疗时的总体有效率的OR值为6.00,95%CI为(3.68,9.79),益生菌在进行急性肠胃炎治疗时的总体显效率的OR值为3.52,95%CI为(2.06,6.01),益生菌在进行急性肠胃炎治疗时降低腹泻时间的均属差(weighted mean difference,WMD)值为-0.79,95%CI为(-1.33,-0.24),且三项均有统计学意义。结论益生菌可以有效地治疗急性肠胃炎,建议临床上使用益生菌治疗急性肠胃炎。
文摘Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary.