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商陆皂苷甲降低银屑病模型小鼠Th17细胞相关细胞因子的表达
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作者 吕瑞华 冯飞雪 +2 位作者 冯昭 马添翼 吕蕊花 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2019年第7期595-600,共6页
目的观察商陆皂苷甲(EsA)对银屑病小鼠17型辅助T(Th17)细胞相关细胞因子表达的影响。方法将48只雌性BALB/c小鼠随机分为空白对照组、模型组、退银汤组[66.60 g/(kg·d)]、 EsA低剂量组[5 mg/(kg·d)],EsA中剂量组[10 mg/(kg... 目的观察商陆皂苷甲(EsA)对银屑病小鼠17型辅助T(Th17)细胞相关细胞因子表达的影响。方法将48只雌性BALB/c小鼠随机分为空白对照组、模型组、退银汤组[66.60 g/(kg·d)]、 EsA低剂量组[5 mg/(kg·d)],EsA中剂量组[10 mg/(kg·d)],EsA高剂量组[20 mg/(kg·d)],每组8只。采用咪喹莫特乳膏诱导小鼠银屑病模型,以皮损面积和严重程度指数(PASI)评分为标准,观察银屑病样小鼠皮损的变化情况;HE染色观察皮损组织形态学变化,ELISA检测小鼠血清Th17细胞相关细胞因子白细胞介素17(IL-17)、IL-22、 IL-6、肿瘤坏死因子α(TNF-α)的水平。结果与模型组相比,退银汤组、 EsA各组PASI评分降低,退银汤组与EsA高剂量组降低较明显;各用药组对银屑病样小鼠背部皮肤组织病理变化减轻;与空白对照组相比,模型组小鼠Th17细胞相关细胞因子水平显著升高,各用药组细胞因子水平明显低于模型组,其中EsA高剂量组IL-6含量接近于空白对照组。结论 EsA可能通过降低Th17细胞相关细胞因子的表达改善银屑病样小鼠皮损状况。 展开更多
关键词 银屑病 商陆皂苷甲 退银汤 Thl7细胞相关因子 银屑病样小鼠模型 银屑病皮损面积和严重度指数(PASI)评分
早发型和晚发型银屑病的遗传学研究进展 预览
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作者 焦运慧 谢媛媛 +1 位作者 刘鑫 骆志成 《医学综述》 2019年第3期439-443,共5页
银屑病是一种常见的慢性复发性炎症性皮肤病,其病因和发病机制目前尚不清楚。根据发病年龄常将银屑病分为早发型银屑病和晚发型银屑病,其中早发型银屑病与遗传的相关性较晚发型银屑病强,且家族史通常阳性。HLA-Cw*0602、角质形成素、嗜... 银屑病是一种常见的慢性复发性炎症性皮肤病,其病因和发病机制目前尚不清楚。根据发病年龄常将银屑病分为早发型银屑病和晚发型银屑病,其中早发型银屑病与遗传的相关性较晚发型银屑病强,且家族史通常阳性。HLA-Cw*0602、角质形成素、嗜乳脂样蛋白2、内质网氨基肽酶1、血管内皮生长因子等是影响早发型银屑病发病的基因。白细胞介素1是影响晚发型银屑病发病的基因。深入探究遗传因素在不同亚型银屑病中的作用,对明确银屑病发病机制、制定合理的治疗措施、降低复发率及提高生活质量有重要意义。 展开更多
关键词 银屑病 早发型银屑病 晚发型银屑病 基因多态性 遗传学
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A New Regimen in the Treatment of Psoriasis Using Oral Methotrexate 预览
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作者 Khalifa E. Sharquie Adil A. Noaimi Mays H. Alobaidi 《化妆品、皮肤病及应用期刊(英文)》 2019年第2期165-176,共12页
Background: Methotrexate is a well-known standard therapy for psoriasis. The standard regimen is using six (2.5 mg) tablets/week that might be with many side effects. Objective: Finding a new regimen for oral methotre... Background: Methotrexate is a well-known standard therapy for psoriasis. The standard regimen is using six (2.5 mg) tablets/week that might be with many side effects. Objective: Finding a new regimen for oral methotrexate aiming to decrease side effects and increase its effectiveness. Patients and Methods: This therapeutic, comparative study done at the Center of Dermatology, Medical city, from October 2017 to October 2018. Fifty-three patients with moderate to severe psoriasis completed the study. They were divided into: Group (A) (27) patients were treated with the new oral regimen and Group (B) (26) patients were treated with the six tablets/week. Investigations including CBC, LFT and RFT were done. PASI score, BSA and side effects especially gastrointestinal ones were recorded. Results: They were 29 males and 24 females. Age ranged from 18 - 67 years. Disease duration ranged from 1 - 30 years. BSA involved ranged from 20% - 79%. The PASI score ranged from 10.2 - 45.7. After 8 weeks of treatment, there was statistically significant difference (p-value > 0.001) regarding PASI score and gastrointestinal side effects being less in Group (A). Group A patients were more satisfied. Conclusion: The new regimen used in the present study has lower gastrointestinal side effects and more efficacy. 展开更多
关键词 PSORIASIS METHOTREXATE NEW REGIMEN
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脓疱型银屑病的生物制剂治疗 预览
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作者 何芳 尹志强 《中国麻风皮肤病杂志》 2019年第4期249-252,共4页
脓疱型银屑病是银屑病中比较严重、治疗困难、可危及患者生命的类型。目前治疗方法主要包括系统使用阿维A酸、环孢素和甲氨喋呤,以及光化学疗法和局部治疗。但一些患者对上述治疗效果不佳,最近国际上报道了一些生物制剂治疗脓疱型银屑... 脓疱型银屑病是银屑病中比较严重、治疗困难、可危及患者生命的类型。目前治疗方法主要包括系统使用阿维A酸、环孢素和甲氨喋呤,以及光化学疗法和局部治疗。但一些患者对上述治疗效果不佳,最近国际上报道了一些生物制剂治疗脓疱型银屑病的临床研究。本文对这些研究进行了综述。 展开更多
关键词 银屑病 生物制剂 脓疱型银屑病
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健脾祛湿法在银屑病湿疹样变中的临床应用研究
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作者 郭岱炯 杨玉峰 +1 位作者 黄艳红 钟玲玲 《广州中医药大学学报》 CAS 2019年第8期1160-1164,共5页
【目的】研究健脾祛湿法在治疗银屑病湿疹样变中的治疗效果。【方法】将60例患者随机分为试验组和对照组,每组各30例。2组患者均给予外涂达力士软膏治疗,在此基础上,试验组给予口服健脾祛湿颗粒治疗,对照组给予口服雷公藤多苷片和开瑞... 【目的】研究健脾祛湿法在治疗银屑病湿疹样变中的治疗效果。【方法】将60例患者随机分为试验组和对照组,每组各30例。2组患者均给予外涂达力士软膏治疗,在此基础上,试验组给予口服健脾祛湿颗粒治疗,对照组给予口服雷公藤多苷片和开瑞坦治疗,疗程1个月。观察2组患者治疗前后银屑病面积与严重性指数评分(PASI)、瘙痒程度视觉模拟评分(VAS)及皮肤病生活质量指标调查表评分(DLQI)的变化情况,评价2组的疗效、安全性及复发情况。【结果】(1)经1个月治疗后,试验组总有效率为93.3%,对照组为73.3%,组间比较,试验组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者PASI、VAS和DLQI评分均较治疗前明显降低(P<0.05),且试验组对各项评分的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)在整个治疗过程中,2组患者均未发生严重不良反应事件。(4)停药1周后,2组患者均没有出现病情复发的情况。【结论】以健脾祛湿法治疗脾虚湿热型银屑病湿疹样变患者疗效显著,在改善瘙痒程度、减少皮损面积及提高患者生活质量方面均优于口服雷公藤多苷片和开瑞坦治疗的对照组,且无毒副作用,安全有效。 展开更多
关键词 银屑病 湿疹样变 健脾祛湿法 健脾祛湿颗粒
银屑病患者外周血TNF-α、IL-17A、IL-23、IL-36γ表达水平及临床意义
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作者 乔菊 高祎濛 +5 位作者 李峰 何春霞 余晓玲 吴超 贾倩楠 晋红中 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2019年第3期280-284,共5页
目的探讨肿瘤坏死因子α(TNF-α)、白细胞介素17A(IL-17A)、白细胞介素23(IL-23)、白细胞介素36γ(IL-36γ)在银屑病患者外周血的表达情况及其与银屑病皮损面积和严重程度指数(PASI)之间的相关性。方法收集中重度斑块型银屑病患者(n=66... 目的探讨肿瘤坏死因子α(TNF-α)、白细胞介素17A(IL-17A)、白细胞介素23(IL-23)、白细胞介素36γ(IL-36γ)在银屑病患者外周血的表达情况及其与银屑病皮损面积和严重程度指数(PASI)之间的相关性。方法收集中重度斑块型银屑病患者(n=66)和健康对照者(n=56)血清,采用酶联免疫吸附试验(ELISA)比较两组人群血清中TNF-α、IL-17A、IL-23、IL-36γ蛋白表达水平有无差异;利用Spearman相关分析法评估患者血清IL-36γ与TNF-α、IL-17A、IL-23表达水平之间有无线性相关关系,TNF-α、IL-17A、IL-23、IL-36γ表达水平与PASI之间有无线性相关关系。结果中重度斑块型银屑病患者血清TNF-α、IL-17A、IL-23、IL-36γ蛋白表达水平均明显高于健康对照组。血清IL-36γ与IL-17A(r=0.783,P<0.001)、IL-23(r=0.929,P<0.001)有显著的正相关关系。血清TNF-α和PASI有明确的正相关关系(r=0.300,P=0.014)。结论银屑病发病可能与多种细胞因子的过度分泌有关,其中银屑病患者外周血IL-36γ与IL-17A、IL-23表达水平具有显著相关性,提示TNF-α/IL-23/IL-17通路与IL-36通路可能存在正向反馈炎性反应环路;TNF-α在中重度斑块型银屑病患者的血清中表达上调,和疾病的严重程度正相关,或可作为辅助评价寻常性银屑病严重程度的相对客观的实验室指标。 展开更多
关键词 银屑病 细胞因子 银屑病皮损面积和严重程度指数(PASI) 相关性 发病机制
Solasodine Glycosides from the Eggplant in a Topical Cream Psorend<sup>BEC</sup>Are Effective against Psoriasis 预览
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作者 Tania R. Chase Kai E. Cham Bill E. Cham 《临床医学国际期刊(英文)》 2019年第3期174-182,共9页
Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can ... Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat psoriasis. Case Presentation: We report a case of a 54-year-old French-Vietnamese male who presented with diagnosed erythematous scaly annular recalcitrant psoriasis scattered throughout his body. Method: After failing conventional treatment regimens for over 10 years the patient received a trial with a topical cream formulation PsorendBEC, containing solasodine glycosides, for his psoriasis. Result: Topical applications of PsorendBEC twice daily resulted in complete resolution of cutaneous lesions after 4 weeks of treatment with no recurrence post 1 year after therapy. Conclusion: Topical PsorendBEC therapy rapidly removes recalcitrant psoriasis with no apparent side effects. 展开更多
关键词 PSORIASIS BEC SOLASODINE GLYCOSIDES PsorendBEC EGGPLANT Devil’s Apple Black Nightshade
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Targeting the Inflammation Culprit in Patients with Psoriasis/Psoriatic Arthritis and Associated Cardiovascular Comorbidities. Is the IL-17 Inhibitor the New Kid on the Block? 预览
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作者 Cornel Pater 《心血管病(英文)》 2019年第4期267-294,共28页
Despite half-century old, but comprehensive national and international guidance, evidence of clinical effectiveness and widespread agreement on management of risk factors along with sophisticated measures for primary ... Despite half-century old, but comprehensive national and international guidance, evidence of clinical effectiveness and widespread agreement on management of risk factors along with sophisticated measures for primary and secondary prevention of major cardiovascular events, cardiovascular disease remains the dominant cause of death and disability world-wide. Life style changes at population-level (e.g., lower salt and saturated fat consumption or reduced/banned amount of industrially-produced trans fatty acids in specific products, etc.) or changes at individual level (e.g., targeting modifiable risk factors/life style changes affecting smoking/tobacco use, poor diet, high blood cholesterol, high blood pressure, insufficient physical activity, overweight/obesity) have reduced coronary heart disease mortality to variable extent in different countries (mostly so reported in Finland, Iceland and Sweden) at the beginning of the new century. Overall, however, cardiovascular mortality is estimated to increase in the next coming years until 2030 at a cost exceeding US $1044 billion. Several decades of status quo are also noted in the therapeutic spectrum of cardiovascular disease, mainly consisting of variations to LDL-C lowering agents, antihypertensives, anticoagulants, antiplatelets and fibrinolytics. Most of the therapeutic interventions are “tertiary” in nature (probably some 60%), meaning that treatment is instituted once the individual has developed a pathologic condition;“secondary prevention” may cover some 25%?-?30% (meant to prevent re-occurrence of the condition or occurrence of complications) while “primary prevention” is left with 10%?-?15% share (most commonly implying life style changes at individual level and rarely pharmacological intervention). For almost three decades, the so-called inflammatory hypothesis has been promoted as a reasonable pathogenetic theory behind initiation and growth of atherosclerotic plaque (Alexander RW, 1994;Ross R, 1999). With the discovery of molecular and cellul 展开更多
关键词 PSORIASIS Psoriatic Arthritis CARDIOVASCULAR COMORBIDITIES INFLAMMATION Cy-tokines IL-17
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托法替布治疗中、重度银屑病的疗效及安全性的系统评价和Meta分析
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作者 张爱玲 孟海阳 +2 位作者 杨莉萍 胡欣 张晓坚 《中国药学杂志》 CAS CSCD 北大核心 2019年第8期665-670,共6页
目的系统评价托法替布对中、重度银屑病的疗效及安全性。方法检索The Cochrane Library、PubMed、EMbase、Clinical Trials、CNKI、万方数据库、维普数据库和中国生物医学文献数据库(CBM),检索时间截至2018年5月,由2位研究者按纳入与排... 目的系统评价托法替布对中、重度银屑病的疗效及安全性。方法检索The Cochrane Library、PubMed、EMbase、Clinical Trials、CNKI、万方数据库、维普数据库和中国生物医学文献数据库(CBM),检索时间截至2018年5月,由2位研究者按纳入与排除标准筛选文献、提取资料并评价纳入研究的质量;采用Rev Man5. 3和Stata 12. 0软件进行Meta分析。结果最终纳入8项随机对照研究(RCT),共3 308例银屑病患者。Meta分析结果显示,与对照组相比,托法替布可显著降低患者银屑病面积和严重程度指数下降75%(RR 3. 27,95%CI:1. 79~5. 98,P=0. 000 1);银屑病面积和严重程度指数下降90%(RR 12. 61,95%CI:7. 66~20. 76,P <0. 000 01);医师整体评估(RR 4. 38,95%CI:3. 51~5. 47,P <0. 000 01)。安全性评价结果显示,与对照组相比,胆固醇水平增加(RR 2. 57,95%CI:1. 22~5. 38,P=0. 01);带状疱疹发生率增加(RR 3. 20,95%CI:0. 86~11. 91,P=0. 08)。结论托法替布临床使用相对安全有效,传统治疗药物效果较差的中重度银屑病患者可采用该药治疗。 展开更多
关键词 托法替布 银屑病 安全性 银屑病面积和严重程度指数 META分析
麻防犀角地黄汤干预寻常性银屑病寒包火证的疗效及作用机制
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作者 刘爱民 张步鑫 +2 位作者 宋坤 吴盘红 徐胜东 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2019年第10期1194-1197,共4页
目的临床观察麻防犀角地黄汤治疗冬季银屑病寒包火证的疗效并探讨其作用机制。方法将确诊为冬季寒包火证的患者90例,随机分为治疗组、对照组A和对照组B,每组各30例。治疗组口服麻防犀角地黄汤加减,对照组A口服犀角地黄汤,对照组B口服阿... 目的临床观察麻防犀角地黄汤治疗冬季银屑病寒包火证的疗效并探讨其作用机制。方法将确诊为冬季寒包火证的患者90例,随机分为治疗组、对照组A和对照组B,每组各30例。治疗组口服麻防犀角地黄汤加减,对照组A口服犀角地黄汤,对照组B口服阿维A胶囊,三组均同法外用卡泊三醇软膏,治疗8周后判断疗效并检测IL-17和VEGF的变化。结果治疗组显效率90.00%(27/30)优于对照组A 40.00%(12/30)和对照组B 46.67%(14/30)(P<0.05);治疗组PASI积分下降程度优于对照组A(P<0.05)和对照组B(P<0.05);治疗前3组患者的IL-17和VEGF值之间差异无统计学意义(P>0.05),治疗组和对照组B治疗前后IL-17差异均有统计学意义(P<0.05),且治疗后两组IL-17差异无统计学意义(P>0.05);3组治疗前后的VEGF差异均有统计学意义(P<0.05),治疗后治疗组VEGF水平低于两个对照组,且差异均有统计学意义(P<0.05)。结论麻防犀角地黄汤对寻常性银屑病寒包火证疗效显著,其机制可能与下调IL-17和VEGF水平有关。 展开更多
关键词 银屑病 寒包火 麻防犀角地黄汤 白细胞介素-17 血管内皮生长因子
Genetic Factors and Psoriatic Arthritis 预览
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作者 Monica Greco Simone Negrini +4 位作者 Chiara Schiavi Francesca Giusti Matteo Borro Francesco Puppo Giuseppe Murdaca 《风湿病与自身免疫疾病期刊(英文)》 2019年第3期111-120,共10页
Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis depends both on genetic factors and environment. PsA patients may present a wide range of clinical manifestations including skin and ... Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis depends both on genetic factors and environment. PsA patients may present a wide range of clinical manifestations including skin and nail abnormalities. Indeed, articular involvement is variable too. Disease development relies on a heterogeneous net made of multiple cytokines pathways which are regulated by several factors including human leucocyte antigen (HLA) expression, miRNAs, microbiome. Among genetic polymorphisms which can lead to abnormal cytokine expression, tumor necrosis factor (TNF) polymorphisms have been studied. Thus, leading to the development of new therapeutic agents. Finally, further studies on genetic factors and epigenetics will give new insights into this complex disorder. The aim of this mini-review is to provide the reader with a summary of the fundamental and most innovative aspects of genetic and epigenetic factors involved in the PsA, thus including human leucocyte antigen (HLA) expression, tumor necrosis factor (TNF) polymorphisms, micro RNAs and microbiome. 展开更多
关键词 Psoriatic ARTHRITIS PSORIASIS HLA Associations Genetic HETEROGENEITY PHENOTYPIC HETEROGENEITY EPIGENETICS Micro RNA MICROBIOME TNF Polymorphisms
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银屑病患者心理干预对生活质量影响的探究 预览
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作者 吴美清 祁冬冬 +2 位作者 刘军 王艳红 张雄 《中国继续医学教育》 2019年第17期81-83,共3页
目的探讨心理干预对银屑病患者生活质量的影响效果。方法选取2017年4月-2019年1月在本院进行医治的46例银屑病患者作为研究对象,将其均等划分为A组与B组,每组各23例患者。A组患者进行常规的治疗,B组在A组的基础上,再进行心理干预。比较... 目的探讨心理干预对银屑病患者生活质量的影响效果。方法选取2017年4月-2019年1月在本院进行医治的46例银屑病患者作为研究对象,将其均等划分为A组与B组,每组各23例患者。A组患者进行常规的治疗,B组在A组的基础上,再进行心理干预。比较两组患者治疗前后的DLQI量表和Zung量表评分。结果干预后,两组患者的DLQI量表各项指标均显著改善,差异均具有统计学意义(P<0.05),且B组患者的改善程度优于A组,差异具有统计学意义(P<0.05);干预后,两组患者的Zung抑郁量表评分和Zung焦虑量表评分都均优于治疗前,差异均具有统计学意义(P<0.05)且B组患者的改善效果优于A组患者,差异具有统计学意义(P<0.05)。结论在银屑病患者的治疗中增加心理干预,能够有效改善患者的负面心理,从而提高患者的生存质量。 展开更多
关键词 银屑病 心理干预 生活质量 DLQI量表评分 Zung量表评分 影响效果
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HLA-Cw6基因对生物制剂治疗银屑病疗效影响的Meta分析 预览
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作者 向志 马一平 +1 位作者 崔盘根 陈敏 《中国麻风皮肤病杂志》 2019年第6期321-326,共6页
目的:Meta分析评价HLA-Cw6基因阳性对生物制剂治疗银屑病疗效的影响。方法:检索1976年1月至2018年12月Pubmed、Embase、The Cochrane Library、中国生物医学文献数据库、万方数据库及中国知网等数据库中关于HLA-Cw6基因与生物制剂疗效... 目的:Meta分析评价HLA-Cw6基因阳性对生物制剂治疗银屑病疗效的影响。方法:检索1976年1月至2018年12月Pubmed、Embase、The Cochrane Library、中国生物医学文献数据库、万方数据库及中国知网等数据库中关于HLA-Cw6基因与生物制剂疗效关联的文献,对最终符合入选标准的文献进行Meta分析。结果:符合入选标准的文献共11篇,涉及三种生物制剂,包括:2项关于IL17A拮抗剂Secukinumab研究,3项抗肿瘤坏死因子α(TNF-α)拮抗剂的研究及6项IL-12/IL-23拮抗剂Ustekinumab的研究。对Ustekinumab疗效关联的6项研究Meta分析显示治疗后HLA-Cw6阳性患者中PASI评分下降75%的比例(PASI75)高于HLA-Cw6阴性患者,差异有统计学意义(P<0.05 )。Secukinumab的2项研究及TNF-α拮抗剂治疗的3项研究Meta分析显示HLA-Cw6阳性患者中PASI75较HLA-Cw6阴性者无明显增高,差异无统计学意义(P>0.05)。结论:携带HLA-Cw6基因患者对IL-12/IL-23拮抗剂Ustekinumab的疗效优于未携带者,HLA-Cw6对Secukinumab和TNF-α拮抗剂疗效无明显影响。 展开更多
关键词 银屑病 HLA-Cw6基因 生物制剂 META分析
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Effect of Traditional Chinese Medicine plus narrow-band medium- wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series
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作者 Li Tiantian Zhou Dongmei +19 位作者 Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping 《中医杂志:英文版》 SCIE CAS CSCD 2019年第5期692-699,共8页
OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with modera... OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. 展开更多
关键词 PSORIASIS ULTRAVIOLET therapy Medicine Chinese Traditional Quality of life
Correlation analysis of Treg/Th17 cells and related cytokines in patients with psoriasis vulgaris
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作者 Qu Tiange Mei Chencheng +2 位作者 Zeng Yajun Li Lingling Duan Xingwu 《中医杂志:英文版》 SCIE CAS CSCD 2019年第5期700-706,共7页
OBJECTIVE: To investigate potential differences in circulating levels of T regulatory (Treg)/T helper 17 (Th17) cells, related inflammatory cytokines and specific transcription factors in healthy individuals and patie... OBJECTIVE: To investigate potential differences in circulating levels of T regulatory (Treg)/T helper 17 (Th17) cells, related inflammatory cytokines and specific transcription factors in healthy individuals and patients with psoriasis conforming to one of three Traditional Chinese Medicine (TCM) syndromes: blood-heat syndrome (BHS), blood-stasis syndrome (BSS) and blood-dryness syndrome (BDS). METHODS: Sixty-seven patients with psoriasis were recruited and assigned to one of three corresponding TCM syndrome groups: BHS (n = 40), BSS (n = 14) and BDS (n = 13 patients). The control group comprised 21 healthy individuals. The circulating levels of Treg/Th17 cells in peripheral blood were assessed using flow cytometry;the levels of inflammatory cytokines interleukin (IL)-10 and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay;and the mRNA expression of T cell-specific transcription factors retinoic acid-related orphan receptor γt (RORγt) and forkhead box P3 (Foxp3) by quantitative real-time PCR. RESULTS: The ratio of Th17 cells and the levels of TNF-α and RORγt were all significantly higher in the BHS and BSS groups than the control group (P < 0.05), while the ratio of Treg cells and the levels of IL-10 and Foxp3 mRNA in the BHS group were significantly lower compared with the control group (P < 0.05). No significant differences were seen between the BSS group and the control group. The ratio of Th17 cells and the levels of TNF-α and RORγt in the BDS group were not significantly different from those of the control group;however, the ratio of Treg cells and the levels of IL-10 and Foxp3 were all lower than those in the healthy controls (P < 0.05). CONCLUSION: Compared with healthy individuals, the ratio of Th17 cells and the levels of related cytokines were higher, while the ratio of Treg cells and the levels of related cytokines were lower, in the peripheral blood of psoriasis/BHS patients;corresponding results for the BSS and BDS groups also showed differences. We propose that patterns of d 展开更多
关键词 PSORIASIS VULGARIS Blood-heat BLOOD STASIS T-Lymphocytes regulatory Th17 cells Medical informatics
银屑病患者肠道菌群多样性分析:单中心前瞻性研究 预览
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作者 王丽玮 段志敏 +3 位作者 童建波 曾荣 徐浩翔 李岷 《协和医学杂志》 CSCD 2019年第3期223-230,共8页
目的探讨银屑病患者与健康人群肠道菌群多样性的差异。方法收集2017年5月至2018年6月间在中国医学科学院皮肤病研究所住院治疗的银屑病患者(银屑病组)及同期本院健康体检人群(健康组)的新鲜粪便标本,分析受试者相关临床资料。提取肠道菌... 目的探讨银屑病患者与健康人群肠道菌群多样性的差异。方法收集2017年5月至2018年6月间在中国医学科学院皮肤病研究所住院治疗的银屑病患者(银屑病组)及同期本院健康体检人群(健康组)的新鲜粪便标本,分析受试者相关临床资料。提取肠道菌群DNA,采用16SrDNA基因扩增和Illumina平台双端2×300策略测序,基于Gold数据库按>97%的相似性聚类操作分类单元(operational taxonomic unit,OTU),对照Silva数据库进行物种注释及分类,各层级样本采用轶和检验分析物种差异;QIIME软件计算α多样性主要指数、β多样性分析,t检验分析指数差异,P<0.05为差异有统计学意义。相关研究结果通过R及GraphPadPrism作图展示。结果符合入选和排除标准的11例银屑病患者及21例健康对照者入选本研究,两组研究对象的性别构成比、年龄和体质量指数无统计学差异(P均>0.05)。DNA测序分析显示样本测序覆盖深度>0.99。银屑病组肠道菌群的OTU数量(278.18±89.75比722.95±152.81,t=10.36,P<0.01)、赵氏指数(433.38±147.47比1156.08±292.50,t=9.291,P<0.01)、香农指数(3.56±0.87比5.73±0.78,t=6.972,P<0.01)和辛普森指数(0.79±0.15比0.94±0.04,t=3.287,P<0.01)均显著低于健康组。Rank-Abundance曲线显示银屑病组肠道菌群均匀程度较低。PCoA分析(unweighted)显示银屑病组与健康组在第一主成分(24.35%)可显著分离,WeightedUniFrac分析可见银屑病组混杂在健康样本中无法区分,且与银屑病亚型无关。样本聚类分析显示,银屑病组肠道菌群与健康组有一定重叠性,银屑病样本特异性菌群少;在门层级,健康组中可检测到TM7,相对丰度为0.0000669(0.0000334~0.0002005),而银屑病组仅在个别样本中显示有微量存在,相对丰度为0(P<0.05);在属层级,银屑病组双歧杆菌属[0.0000334(0.0000167~0.0001003)比0.0004011(0.0002005~0.0013370)]、布劳特氏菌属[0.0004679(0.0001838~0.0004345)比0.0022060(0.0009359~0.0055820)]、粪 展开更多
关键词 银屑病 肠道菌群 16SrDNA 测序
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三维质控护理措施对银屑病院外延续性护理的效果研究 预览
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作者 谭燕 邓兴华 《中外女性健康研究》 2019年第12期21-22,共2页
目的:研究三维质控护理措施对银屑病院外延续性护理的效果。方法:选取本院就诊的102例银屑病患者,采用随机数表法将其随机均分为观察组(51例)和对照组(51例),对照组采用常规护理,观察组采用三维质控护理措施实施院外延续性护理,护理后,... 目的:研究三维质控护理措施对银屑病院外延续性护理的效果。方法:选取本院就诊的102例银屑病患者,采用随机数表法将其随机均分为观察组(51例)和对照组(51例),对照组采用常规护理,观察组采用三维质控护理措施实施院外延续性护理,护理后,比较两组患者护理前后生活质量和满意度。结果:两组患者护理后躯体功能、社会功能、精神健康、活力、情绪角色、总体健康评分差异显著,观察组患者评分优于对照组,两组比较有统计学差异(P<0.05)。观察组患者满意度(96.08%)明显高于对照组(50.98%),两组患者比较差异有统计学意义(P<0.05)。结论:使用三维质控护理措施对银屑病院外延续性护理效果显著,可改善患者生活质量,提升患者满意度。 展开更多
关键词 三维质控护理措施 银屑病 院外延续性护理 效果研究
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虫类药治疗银屑病的体会 预览
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作者 乔民 苗德光 《中国中医药现代远程教育》 2019年第6期26-27,36共3页
虫类药物性攻逐走窜,可通经达络,搜剃疏利而无所不至;同时,虫类药为血肉有情之品。对于银屑病的治疗,可以充分发挥其祛邪及补虚两个方面的优势。已故国医大师朱良春教授善用虫类药物,本文在对朱老运用虫类药物经验继承的基础上,在运用... 虫类药物性攻逐走窜,可通经达络,搜剃疏利而无所不至;同时,虫类药为血肉有情之品。对于银屑病的治疗,可以充分发挥其祛邪及补虚两个方面的优势。已故国医大师朱良春教授善用虫类药物,本文在对朱老运用虫类药物经验继承的基础上,在运用部分虫类药物治疗银屑病的体会进行了初步归纳与总结。 展开更多
关键词 僵蚕 蝉蜕 地龙 蜈蚣 全蝎 银屑病
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重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白对中重度银屑病患者血清脂肪因子水平的影响:前瞻性非随机对照试验 预览
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作者 乔菊 李峰 +2 位作者 何春霞 吴超 晋红中 《协和医学杂志》 CSCD 2019年第3期243-248,共6页
目的分析注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白对中重度斑块型银屑病患者血清脂联素(adiponectin,APN)、视黄醇结合蛋白4(retinol binding protein 4,RBP4)、瘦素(leptin,LEP)3种脂肪因子水平的影响。方法选取2016年11月至201... 目的分析注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白对中重度斑块型银屑病患者血清脂联素(adiponectin,APN)、视黄醇结合蛋白4(retinol binding protein 4,RBP4)、瘦素(leptin,LEP)3种脂肪因子水平的影响。方法选取2016年11月至2018年5月在北京协和医院皮肤科就诊的30例中重度斑块型银屑病患者作为治疗组,同时选取在本院健康医学部进行体检的25名健康人作为健康对照组。治疗组均给予重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白50mg皮下注射,每周1次,共12次。检测健康对照组及治疗组治疗前(基线)和治疗后12周血清APN、RBP4、LEP的浓度;分析两组之间以及治疗组治疗前后血清脂肪因子水平是否存在差异,并采用Spearman相关分析法评估治疗组基线血清APN、RBP4、LEP表达水平与银屑病皮损面积和严重程度指数(psoriasis area and severity index,PASI)之间有无线性相关关系。结果治疗组基线APN水平[9.73(6.69,12.37)比(14.25(10.53,23.28),P<0.001]、LEP水平[0.42(0.17,2.60)比3.90(1.38,7.20),P=0.002]较健康对照组降低,RBP4较健康对照组升高[12.29(10.62,21.33)比9.13(7.36,15.78),P=0.024];治疗组治疗后APN水平[11.95(8.12,15.26)比9.73(6.69,12.37),P=0.027]、LEP水平[2.84(1.04,9.34)比0.42(0.17,2.60),P<0.001]较治疗前明显升高,而RBP4水平较治疗前差异无统计学意义(P=0.125);基线APN、RBP4、LEP浓度均与PASI无线性相关关系。结论脂肪因子可能参与了银屑病的慢性炎症过程,抗肿瘤坏死因子α治疗可能改善银屑病的炎症状态。 展开更多
关键词 银屑病 脂联素 视黄醇结合蛋白4 瘦素 重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白
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凉血解毒汤联合窄谱中波紫外线治疗寻常性银屑病血热证的临床观察
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作者 毛常亮 苏孟 +1 位作者 周双琳 杨蓉娅 《实用皮肤病学杂志》 2019年第2期106-108,共3页
目的观察中药汤剂凉血解毒汤联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病血热证的临床疗效。方法将96例寻常性银屑病血热证患者随机分为试验组和对照组,每组48例,试验组给予凉血解毒汤联合NB-UVB照射治疗,对照组只给予NB-UVB照射治疗,... 目的观察中药汤剂凉血解毒汤联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病血热证的临床疗效。方法将96例寻常性银屑病血热证患者随机分为试验组和对照组,每组48例,试验组给予凉血解毒汤联合NB-UVB照射治疗,对照组只给予NB-UVB照射治疗,两组均同时外用白凡士林治疗,4周后采用银屑病皮损面积及严重度指数(PASI)评分评价疗效。结果试验组治愈15例(31.3%)、显效20例(41.7%)、好转11例(22.9%)、无效2例(4.2%),总有效率95.8%;对照组治愈10例(20.8%)、显效13例(27.1%)、好转18例(37.5%)、无效7例(14.6%),总有效率85.4%;两组比较差异有统计学意义(P<0.05)。两组治疗前后PASI评分比较,试验组和对照组治疗前后PASI评分比较,差异均有统计学意义(P均<0.05);两组间治疗前PASI评分比较,差异无统计学意义(P> 0.05),两组治疗后PASI评分差异有统计学意义(P <0.05)。结论两组治疗均有效且试验组疗效优于对照组,中药凉血解毒汤联合NB-UVB治疗寻常性银屑病血热证临床疗效确切,安全性高。 展开更多
关键词 银屑病 寻常性 凉血解毒汤 窄谱中波紫外线 血热证
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