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Effect of site amplifi cation on inelastic seismic response 预览
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作者 Adhikary S Singh Y 《地震工程与工程振动:英文版》 SCIE EI CSCD 2019年第3期535-554,共20页
The available models for eff ective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system. The eff ect of seismic intensity and ductility ... The available models for eff ective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system. The eff ect of seismic intensity and ductility demand, on the eff ective periods, is investigated, and inelastic site amplifi cation is shown to be strongly correlated to the normalized eff ective period. Two non-dimensional parameters, analogous to the conventional site amplifi cation factors in codes, are defi ned to quantify the inelastic site amplifi cation. It is shown that the inelastic site amplifi cation factor (i.e. ratio of constant ductility spectral ordinates at soil site to those at rock outcrop) is able to represent the site eff ects more clearly, as compared to the inelastic site amplifi cation ratio (i.e. ratio of inelastic spectral ordinates at soil site to the corresponding elastic spectral ordinates at rock outcrop). Further, the peak in the amplifi cation factor corresponding to the eff ective site period diminishes rapidly with increasing ductility demand. 展开更多
关键词 SITE amplifi CATION normalized RESPONSE SPECTRA eff ective period INELASTIC SEISMIC RESPONSE INELASTIC SITE amplifi CATION factor
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Effects of adjuvant raw rhubarb enema therapy on systemic inflammatory stress response and intestinal mucosal barrier function in patients with severe pancreatitis
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作者 Ping Fang Xian-Hua Xiao 《海南医科大学学报(英文版)》 2019年第9期50-53,共4页
Objective: To investigate the effects of adjuvant raw rhubarb enema therapy on systemic inflammatory stress response and intestinal mucosal barrier function in patients with severe pancreatitis. Methods: A total of 78... Objective: To investigate the effects of adjuvant raw rhubarb enema therapy on systemic inflammatory stress response and intestinal mucosal barrier function in patients with severe pancreatitis. Methods: A total of 78 patients with severe pancreatitis treated in the Second People's Hospital of Neijiang, Sichuan, China between December 2016 and September 2018 were included in the study. The patients were divided into control group (n=39) and raw rhubarb group (n=39) by simple randomization. The control group of patients received conventional treatment of severe pancreatitis with western medicine, while the raw rhubarb group of patients received raw rhubarb enema on the basis of the treatment of control group, and the efficacy was evaluated after continuous treatment for 1 week. The differences in serum levels of inflammatory mediators (high mobility group protein B1, C-reactive protein, prostaglandin E2 and tumor necrosis factor α), stress hormones (cortisol and epinephrine) as well as intestinal mucosal barrier function indicators (D-lactate, endotoxin and diamine oxidase) were compared between the two groups of patients before and after treatment. Results: Before treatment, there was no statistically significant difference in serum levels of inflammatory mediators, stress hormones and intestinal mucosal barrier function indicators between the two groups (P>0.05). After treatment, serum high mobility group protein B1, C-reactive protein, prostaglandin E2 and tumor necrosis factor levels of the observation group were significantly lower than those of the control group;cortisol and epinephrine levels were significantly lower than those of the control group;D-lactate, endotoxin and diamine oxidase levels were significantly lower than those of the control group (P<0.05). Conclusions:Adjuvant raw rhubarb enema therapy on the basis of western medicine can help alleviate the inflammatory stress response and optimize the intestinal mucosal barrier function in patients with severe pancreatitis. 展开更多
关键词 SEVERE PANCREATITIS RAW RHUBARB enema SYSTEMIC INFLAMMATORY response Stress response Intestinal mucosal barrier function
Effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy
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作者 Jun Li Xiao-Hong Zhang 《海南医科大学学报(英文版)》 2019年第3期31-35,共5页
Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy trea... Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy treated in our hospital between February 2015 and April 2017 were chosen and divided into two groups by random number table, observation group received Qishen Yiqi Drop Pill combined with conventional therapy and control group accepted conventional therapy. The renal function indexes, cytokine contents and oxygen free radical generation were compared before treatment and 3 months after treatment. Results:Urine UREA levels as well as serum β2 microglobulin (β2-MG), cystatin C (CysC), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), stromal cell-derived factor-1 (SDF-1), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) contents of both groups were significantly lower while superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) contents were significantly higher after treatment, and urine UREA level as well as serum β2-MG, CysC, TNF-α, IL-6, SDF-1, IL-17, TGF-β1, MDA and 8-iso-PGF2α contents of observation group after treatment was significantly lower than those of control group while SOD and T-AOC contents were significantly higher than those of control group. Conclusion: Adjuvant Qishen Yiqi Drop Pill therapy can improve the renal function and reduce the inflammatory response and oxidative stress response in early diabetic nephropathy. 展开更多
关键词 DIABETIC NEPHROPATHY Qishen Yiqi DROP PILL Renal function Inflammatory RESPONSE Oxidative stress RESPONSE
Temperature-induced hormesis in plants 预览
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作者 Evgenios Agathokleous Mitsutoshi Kitao +1 位作者 Hisanori Harayama Edward J.Calabrese 《林业研究:英文版》 CAS CSCD 2019年第1期13-20,共8页
Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress.To investigate these,dose– response relationships should be clarified.It was previous... Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress.To investigate these,dose– response relationships should be clarified.It was previously assumed that the fundamental nature of biological dose– responses follows a linear model,either with no threshold or with a threshold below which no effects are expected to occur in biological endpoints.However,substantial literature,including widespread documentation in plants,has revealed that hormesis commonly occurs.Hormesis is highly generalized and can be utilized as a quantitative measure of biological plasticity.Conditioning induced by adaptive responses also occurs in the framework of hormesis and is of particular importance to environmental change biology with regards to evolutionary adaptations.This paper presents additional evidence for hormetic dose responses induced by temperature in plants.The current understanding on hormesis provides a perspective for next generation environmental change research.Hormesis should have a central role in environmental change biology of vegetation. 展开更多
关键词 Adaptive RESPONSE Biological PLASTICITY DOSE RESPONSE HORMESIS Stress BIOLOGY
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Design of Computationally Efficient Sharp FIR Filter Utilizing Modified Multistage FRM Technique for Wireless Communications Systems 预览
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作者 Tirthadip Sinha Jaydeb Bhaumik 《电子科技学刊:英文版》 CAS CSCD 2019年第2期185-192,共8页
Modern wireless communications gadgets demand multi-standard communications facilities with least overlap between different input radio channels. A sharp digital filter of extremely narrow transition-width with lower ... Modern wireless communications gadgets demand multi-standard communications facilities with least overlap between different input radio channels. A sharp digital filter of extremely narrow transition-width with lower stop band ripples offers alias-free switching among the preferred frequency bands. A computationally competent low pass filter (LPF) structure based on the multistage frequency response masking (FRM) approach is proposed for the design of sharp finite impulse response (FIR) filters which are suitable for wireless communications applications. In comparison of basic FRM with other existing multistage FRM structures, the proposed structure has a narrow transition bandwidth and higher stop band attenuation with significant reduction in terms of the number of computational steps. A design example is incorporated to demonstrate the efficiency of the proposed approach. Simulation results establish the improvement of the proposed scheme over other recently published design strategies. 展开更多
关键词 MULTISTAGE frequency RESPONSE MASKING narrow transition-width SHARP finite IMPULSE RESPONSE filter wireless communications
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Correlation of serum apoptotic molecule and cytokine levels with cognitive function in epileptic patients
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作者 Wen Tang Mei-Mei Yang +1 位作者 Ya-Ning Tang Yan Zhao 《海南医科大学学报(英文版)》 2019年第12期28-31,共4页
Objective:To investigate the correlation of serum apoptotic molecule and cytokine levels with cognitive function in epileptic patients.Methods: 78 adult epileptic patients admitted to our hospital between December 201... Objective:To investigate the correlation of serum apoptotic molecule and cytokine levels with cognitive function in epileptic patients.Methods: 78 adult epileptic patients admitted to our hospital between December 2016 and December 2018 were selected as the epilepsy group, and 50 normal people who underwent physical examination in our hospital during the same period were selected as the normal control group. The differences in serum levels of apoptotic molecules [bcl-1, bax, survivin, caspase-3, caspase-4 and caspase-10], inflammatory factors [interleukin-1β (IL-1β), interleukin-2 (IL-2), tumor necrosis factor (TN-α) and high mobility group protein B1 (HMGB1)], oxidative stress indexes [advanced oxidation protein product (AOPP), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px)] and adipokines [adiponectin (APN) and leptin] as well as Mini-Mental State Examination (MMSE) scores were compared between the two groups, and Pearson test was used to evaluate the correlation of serum apoptotic molecule and cytokine levels with cognitive function in patients with epilepsy.Results: Serum bcl-1 and survivin levels in the epilepsy group were lower than those in the normal control group, while bax, caspase-3, caspase-4 and caspase-10 levels were higher than those in the normal control group;serum IL-1β, IL-2, TNF-α and HMGB1 levels were all higher than those in the normal control group;serum AOPP and MDA levels were higher than those in the normal control group, while GSH-Px level was lower than that in the normal control group;serum APN level was lower than that in the normal control group, while Leptin level was higher than that in the normal control group;MMSE score was significantly lower than that in the normal control group (P<0.05). Pearson test showed that the serum levels of apoptotic molecules, inflammatory factors, oxidative stress indexes and adipokines in epileptic patients were directly correlated with MMSE score (P<0.05).Conclusion:The cognitive function of epileptic patients is affected by apopto 展开更多
关键词 EPILEPSY APOPTOTIC MOLECULE Inflammatory RESPONSE Oxidative stress RESPONSE ADIPOKINE Cognitive function
Volatiles from Sophora japonica flowers attract Harmonia axyridis adults(Coleoptera:Coccinellidae) 预览
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作者 XIU Chun-li XU Bin +3 位作者 PAN Hong-sheng ZHANG Wei YANG Yi-zhong LU Yan-hui 《农业科学学报:英文版》 SCIE CAS CSCD 2019年第4期873-883,共11页
The multicolored Asian lady beetle,Harmonia axyridis(Coleoptera:Coccinellidae),is a common generalist predator in China and is occasionally found gathering on the Chinese pagoda tree,Sophora japonica,in summer.In a fi... The multicolored Asian lady beetle,Harmonia axyridis(Coleoptera:Coccinellidae),is a common generalist predator in China and is occasionally found gathering on the Chinese pagoda tree,Sophora japonica,in summer.In a field investigation,we found that H.axyridis adults preferred S.japonica during its flowering period even though their optimal prey(aphid)is absent at this time.In addition,male and female adults were attracted to S.japonica flowers to a similar extent in a Y-tube olfactometer assay.Using coupled gas chromatography-electroantennogram detection(GC-EAD),we identified a flower odor component(nonanal)that elicited a significant electrophysiological response in H.axyridis.Electroantennogram(EAG)dose-dependent responses revealed that the amplitude of the adult beetle’s EAG response increased with increasing concentration of nonanal,peaking at 10 mg mL^–1.In Y-tube olfactometer behavioral tests,H.axyridis adults preferred a 10 mg mL^–1 nonanal source over a 100 mg mL^–1 diluent.Under field conditions,the adults were significantly attracted to both concentrations(10 and 100 mg mL^–1),and high concentrations generally had greater attraction.All these results suggest that nonanal,a volatile compound of S.japonica flowers,greatly attracts H.axyridis adults.This study provides a basis for the development of synthetic attractants of H.axyridis,with the potential to promote biocontrol services of this generalist predator in the native area(e.g.,China)and to suppress its population by mass trapping in its invasive areas. 展开更多
关键词 flower preference plant volatile electrophysiological RESPONSE BEHAVIORAL RESPONSE ATTRACTANTS
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Nomograms for predicting pathological response to neoadjuvant treatments in patients with rectal cancer 预览
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作者 Dong-Lin Ren Juan Li +5 位作者 Hui-Chuan Yu Shao-Yong Peng Wei-Da Lin Xiao-Lin Wang Roshan Ara Ghoorun Yan-Xin Luo 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第1期118-137,共20页
BACKGROUND In recent decades,neoadjuvant therapy(NT)has been the standardized treatment for locally advanced rectal cancer(LARC).Approximately 8%-35%of patients with LARC who received NT were reported to have achieved... BACKGROUND In recent decades,neoadjuvant therapy(NT)has been the standardized treatment for locally advanced rectal cancer(LARC).Approximately 8%-35%of patients with LARC who received NT were reported to have achieved a complete pathological response(pCR).If the pathological response(PR)can be accurately predicted,these patients may not need surgery.In addition,no response after NT implies that the tumor is destructive,resistant to both chemotherapy and radiotherapy,and prone to having a high metastatic potential.Therefore,developing accurate models to predict PR has great clinical significance and can help achieve individualized treatment in LARC patients.AIM To establish nomograms for predicting PR to different NT regimens based on pretreatment parameters for patients with LARC.METHODS Rectal cancer patients were identified from the database of The Sixth Affiliated Hospital,Sun Yat-sen University from January 2012 to December 2016.Logistic regression and nomograms were developed to predict the probability of pCR and good downstaging to ypT0-2N0M0(ypTNM 0-I),respectively,based on pretreatment parameters for all LARC patients.Nomograms were also developed for three NT regimens(capecitabine/deGramont-RT,mFOLFOX6,and mFOLFOX6-RT)to predict pCR probability.RESULTS Four hundred and three patients were included in this study;72(17.9%)had pCR at the final pathology report,and 177(43.9%)achieved good downstaging to ypT0-2N0M0(ypTNM 0-I).The nomogram for predicting pCR probability showed that NT regimens,tumor differentiation,mesorectal fascia(MRF)status,and tumor length significantly influenced pCR probability.When predicting the probability of good downstaging,tumor differentiation,MRF status,and clinical T stage were the significant factors.Nomograms were developed based on NT regimens.For the capecitabine/de Gramont-RT group,the multivariate analysis showed that the neutrophil-lymphocyte ratio(NLR)was the only significant factor,thus we could not develop a nomogram for this regimen.For the mFOLFOX6-RT group,the analy 展开更多
关键词 NEOADJUVANT therapy Locally advanced rectal cancer NOMOGRAM Prediction of PATHOLOGICAL RESPONSE Complete PATHOLOGICAL RESPONSE Good DOWNSTAGING
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A time-domain nonlinear effective-stress non-Masing approach of ground response analysis of Guwahati city, India 预览
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作者 Devdeep Basu Madhulatha Boga Arindam Dey 《地震工程与工程振动:英文版》 SCIE EI CSCD 2019年第1期61-75,共15页
The response of subsoil strata subjected to seismic excitations plays an important role in governing the response of the overlying superstructures at any site. Ground response analysis(GRA) helps to assess the influen... The response of subsoil strata subjected to seismic excitations plays an important role in governing the response of the overlying superstructures at any site. Ground response analysis(GRA) helps to assess the influence of soil characteristics on the propagating seismic stress waves from the bedrock level to the ground surface during an earthquake. For the northeastern region of India, located in the highest seismic zone in the country, conducting an extensive GRA study is of prime importance. Conventionally, most of the GRA studies are carried out using the equivalent linear method, which, being a simplistic approach, cannot capture the nonlinear behavior of soil during seismic shaking. This paper presents the outcomes of a one-dimensional effective stress based nonlinear GRA conducted for Guwahati city(located in northeast India) incorporating the non-Masing load/unload/reload characteristics. The various ground response parameters evaluated from this study help in assessing the ground shaking, soil amplification, and site responses expected in this region. 2D contour maps, which are representative of the distribution of some of these parameters throughout Guwahati city, are also developed. The results presented herein can serve as guidelines for the design of foundations and superstructures in this region. 展开更多
关键词 GROUND RESPONSE analysis nonlinear effective STRESS APPROACH non-masing criteria GROUND RESPONSE parameters soil amplification
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Effect of short-term metformin therapy on micro-inflammatory response and oxidative stress response in obese patients with NAFLD
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作者 Kun Wang Li-Ping Shen 《海南医科大学学报(英文版)》 2019年第8期45-48,共4页
Objective:To explore the effect of short-term metformin therapy on micro-inflammatory response and oxidative stress response in obese patients with NAFLD.Methods: Obese patients with NAFLD who received treatment in ou... Objective:To explore the effect of short-term metformin therapy on micro-inflammatory response and oxidative stress response in obese patients with NAFLD.Methods: Obese patients with NAFLD who received treatment in our hospital between March 2014 and January 2018 were selected for retrospective study and divided into control group receiving conventional therapy and the metformin group receiving conventional therapy combined with short-term metformin therapy. Before treatment and 2 weeks after treatment, serum levels of inflammatory factors and oxidative stress indexes were measured.Results: Before treatment, there was no significant difference in serum levels of inflammatory factors or oxidative stress indexes between the two groups. After 2 weeks of treatment, the serum levels of IL-1β, IL-6, IL-18, IL-33, AOPPs, ROS and LHP of both groups decreased, while the levels of SOD and T-AOC increased and the serum levels of IL-1β, IL-6, IL-18, IL-33, AOPPs, ROS and LHP of observation group were lower than those of control group, while the levels of SOD and T-AOC were higher than those of control group.Conclusion: Short-term metformin can effectively inhibit the micro-inflammatory state and reduce the oxidative stress response in obese patients with NAFLD. 展开更多
关键词 Non-alcoholic FATTY liver disease OBESITY METFORMIN Inflammatory RESPONSE Oxidative stress RESPONSE
Effect of Xuebijing combined with ulinastatin on the homeostasis of sepsis patients
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作者 Wei Chen 《海南医科大学学报(英文版)》 2019年第13期41-45,共5页
Objective:To investigate the effect of Xuebijing combined with ulinastatin on the homeostasis of sepsis patients.Methods: 78 patients with post-burn sepsis who received treatment in our hospital between January 2016 a... Objective:To investigate the effect of Xuebijing combined with ulinastatin on the homeostasis of sepsis patients.Methods: 78 patients with post-burn sepsis who received treatment in our hospital between January 2016 and January 2019 were included in the study. The treatment regimen was retrospectively analyzed and used to divide the patients into the group A (n=40) receiving ulinastatin treatment and the group B (n=38) receiving Xuebijing combined with ulinastatin treatment. The efficacy was evaluated after 7 d of continuous treatment.Results:Before treatment, there were no significant differences in levels of inflammatory factors, oxidative stress indicators, myocardial injury markers or coagulation function indicators between the two groups. After treatment, serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) contents in group B were lower than those in group A;serum total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) contents were higher than those in group A, while lipid hydroperoxide (LHP) and advanced protein oxidation product (AOPP) contents were lower than those in group A;serum lactate dehydrogenase (LDH), troponin I (cTn I) and B-type brain natriuretic peptide (BNP) contents were lower than those in group A;peripheral blood prothrombin time (PT), thrombin time (TT) and partial thromboplastin time (APTT) levels were higher than those in group A, while fibrinogen (FIB) level was lower than that in group A.Conclusion: Xuebijing combined with ulinastatin can effectively reduce the inflammatory stress response, actively protect the myocardial function and reduce the hypercoagulable state in patients with post-burn sepsis. 展开更多
关键词 SEPSIS XUEBIJING ULINASTATIN Inflammatory RESPONSE Oxidative stress RESPONSE MYOCARDIAL injury
Correlation of peripheral blood T cell changes with nerve damage, inflammatory response and stress response in patients with acute cerebral infarction
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作者 Qi Lei Ting-Ge Zhu Rui Liu 《海南医科大学学报(英文版)》 2019年第9期15-19,共5页
Objective: To investigate the correlation of peripheral blood T cell changes with nerve damage, inflammatory response and stress response in patients with acute cerebral infarction. Methods: 108 patients with acute ce... Objective: To investigate the correlation of peripheral blood T cell changes with nerve damage, inflammatory response and stress response in patients with acute cerebral infarction. Methods: 108 patients with acute cerebral infarction who received emergency treatment in Xuefu Hospital of Shaanxi Normal University between September 2015 and August 2017 were selected as the cerebral infarction group, and 100 healthy elderly volunteers who underwent physical examination during the same period were selected as the normal control group. The differences in the expressions of CD4+CD25+ regulatory T lymphocytes in peripheral blood as well as the levels of nerve damage indicators, inflammatory factors and oxidative stress indicators in serum were compared between the two groups. Pearson test was used to evaluate the intrinsic relationship between peripheral blood CD4+CD25+ regulatory T lymphocyte expression and infarction condition in patients with acute cerebral infarction. Results:Peripheral blood CD4+CD25+ regulatory T lymphocyte expression of the cerebral infarction group was higher than that of the normal control group;serum nerve damage indicators UCH-L1, GFAP, and Ang-1 levels were higher than those of the normal control group while IGF-1 and BDNF levels were lower than those of the normal control group;serum inflammatory factors IL-1β, VCAM-1, IL-13, and IL-18 levels were higher than those of the normal control group;serum oxidative stress indicators CAT and T-SOD levels were lower than those of the normal control group whereas MDA level was higher than that of the normal control group. Correlation analysis confirmed that peripheral blood CD4+CD25+ regulatory T lymphocyte expression in patients with acute cerebral infarction was directly correlated with the levels of nerve damage indicators, inflammatory factor, and oxidative stress indicators. Conclusion:The abnormal increase of peripheral blood CD4+CD25+ regulatory T lymphocyte expression in patients with acute cerebral infarction is related to the aggravation 展开更多
关键词 Acute CEREBRAL INFARCTION T cell NERVE damage Inflammatory RESPONSE OXIDATIVE stress RESPONSE
Relationship between the high frequency of 23S rRNA point mutations in Treponema pallidum and low serological response rate to azithromycin treatment in China
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作者 Rui-Li Zhang Qian-Qiu Wang +5 位作者 Zhi-Ju Zheng Guo-Jun Liang Li-Jia Yang Li-Gang Yang Dong-Nu Pei Shao-Chun Lin 《国际皮肤性病学杂志(英文)》 2019年第1期6-14,共9页
Objective Although azithromycin is effective against Treponema pallidum (T.pallidum),the causative agent of syphilis,recent reports indicate that the prevalence of azithromycin resistance in China is very high,which m... Objective Although azithromycin is effective against Treponema pallidum (T.pallidum),the causative agent of syphilis,recent reports indicate that the prevalence of azithromycin resistance in China is very high,which may result in the failure of treatment.In this study,we aimed to investigate the association between azithromycin resistance and therapeutic outcomes in early syphilis patients.Methods Between February 2010 and December 2014,patients aged 18-65 years with early syphilis were enrolled.T.pallidum DNA were extracted to test the presence of A2058G and A2059G mutations.Then,eligible patients were randomly assigned to receive oral azithromycin (0.5 g,once daily for 15 days) or intramuscular BPG (2.4 million units,once weekly for 3 weeks).All patients were followed up in 2 weeks and 3,6,9,and 12 months after treatment to collect demographic and clinical characteristics and laboratory results.The differences on serological response,serological failure and serofast rate were compared between the two groups by Chi-square test.Results Among the 187 T.pallidum-infected patients enrolled,172 (92.0%) cases had a mutation associated with azithromycin resistance (A2058G,153 cases;A2059G,19 cases).During the 5-year study period,the percentage of cases enrolled with these mutations steadily increased,from 90.9% in 2010 to 95.3% in 2014.Of the 172 patients presenting with these mutations,only 78 (45.3%;all benzathine penicillin G [BPG]-treated) obtained a serological response to treatment;32.6% and 22.1% of patients presented with serological failure and serofast results,respectively.For azithromycin-treated cases,66.3% and 33.7% had serological failure and serofast results,respectively,in contrast with 1.1% and 11.3% of BPG-treated cases.However,among the A2058G-and A2059G-negative patients,the serological response rates between the two treatment groups were similar.In multivariate analyses,patients with lower rapid plasma reagin (RPR) titers (RPR,≤ 1 ∶ 8;odds ratio [OR],0.23;95% confidence interval [CI],0.09-0.37) 展开更多
关键词 SYPHILIS AZITHROMYCIN MUTATION SEROLOGICAL response TREPONEMA PALLIDUM
Effectiveness of taxanes over anthracyclines in neoadjuvant setting: A systematic-review and meta-analysis 预览
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作者 Mona Pathak Sada Nand Dwivedi +3 位作者 SVS Deo Bhaskar Thakur Vishnubhatla Sreenivas Goura Kishor Rath 《世界荟萃分析杂志》 2019年第4期170-183,共14页
BACKGROUND Anthracyclines and taxanes are more active group of chemotherapy regimen. Randomized controlled trials (RCTs) reported variable evidences regarding efficacy of taxanes over anthracyclines for tumor response... BACKGROUND Anthracyclines and taxanes are more active group of chemotherapy regimen. Randomized controlled trials (RCTs) reported variable evidences regarding efficacy of taxanes over anthracyclines for tumor response and survival outcomes. The present study compares the relative efficacy of taxanes over anthracyclines using pathological complete response (pCR), clinical responses, breast-conserving surgeries and survival outcomes in female breast cancer patients by systematic review and meta-analysis of available RCTs. AIM To assess the effectiveness of taxanes over anthracyclines in neoadjuvant setting in terms of tumor response and survival outcomes. METHODS All RCTs assessing efficacy of taxanes over anthracyclines in neoadjuvant setting for management of breast cancer searched through PubMed and Cochrane register of controlled trials on 28 April 2017 and published in English language were considered. Following PRISMA guideline, retrieved records were screened and data were extracted by two independent reviewers. Meta-analysis was performed using fixed effect or random effect method depending on heterogeneity assessed using I2 statistic. Subgroup meta-analyses on the basis of taxane alone or taxane along with anthracycline in comparison to anthracycline alone were also performed for each considered outcomes.A total of 16 RCTs involving 6752 breast cancer patients were found eligible. Taxanes based chemotherapy significantly improved pCR (n = 7, RR = 1.48, 95%CI: 1.04-2.12), disease free survival [n = 6, RR = 0.89 (0.80-0.99)] and locoregional recurrence free survival [n = 4, RR = 0.74 (0.59-0.94)]. Interestingly in subgroup analysis, addition of taxane to anthracyclines showed better effectiveness regarding these survivals over anthracyclines than taxane alone over anthracycline. CONCLUSION Addition of taxanes to anthracyclines based chemotherapy significantly improves pCR, disease free survival and loco-regional recurrence free survival but with no significant impact on breast conservation rates. 展开更多
关键词 DOCETAXEL Paclitaxel EPIRUBICIN Doxorubicin Pathological complete response Breast CONSERVING surgery
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Fluoride removal from secondary effluent of the graphite industry using electrodialysis:Optimization with response surface methodology
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作者 Xiaomeng Wang Ning Li +8 位作者 Jianye Li Junjun Feng Zhun Ma Yuting Xu Yongchao Sun Dongmei Xu Jian Wang Xueli Gao Jun Gao 《环境科学与工程前沿(英文)》 SCIE EI CAS CSCD 2019年第4期45-55,共11页
Response surface methodology was utilized to model and optimize the operational variables for defluoridation using an electrodialysis process as the treatment of secondary effluent of the graphite industry. Experiment... Response surface methodology was utilized to model and optimize the operational variables for defluoridation using an electrodialysis process as the treatment of secondary effluent of the graphite industry. Experiments were conducted using a Box-Behnken surface statistical design in order to evaluate the effects and the interaction of the influential variables including the operational voltage, initial fluoride concentration and flow rate. The regression models for defluoridation and energy consumption responses were statistically validated using analysis of variance (ANOVA);high coefficient of determination values (R^2 = 0.9772 and R^2 = 0.9814;respectively) were obtained. The quadratic model exhibited high reproducibility and a good fit of the experimental data. The optimum values of the initial fluoride concentration, voltage and flow rate were found to be 13.9 mg/L, 13.4 V, 102.5 L/h, respectively. A fluoride removal efficiency of 99.69% was observed under optimum conditions for the treatment of the secondary effluent of the graphite industry. 展开更多
关键词 Response surface METHODOLOGY FLUORIDE REMOVAL ELECTRODIALYSIS Box-Behnken design
Optimal Method of Extraction Process of Flavonoids from Ginkgo biloba 预览
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作者 Qun CHEN Lang TANG Shitang MA 《亚洲农业研究:英文版》 2019年第7期66-70,共5页
[Objectives] To optimize the extraction of total flavone in folium Ginkgo biloba leaves.[Methods] Using the ultrasonic extraction method, the three levels of maximum impact were selected by each factor selection, and ... [Objectives] To optimize the extraction of total flavone in folium Ginkgo biloba leaves.[Methods] Using the ultrasonic extraction method, the three levels of maximum impact were selected by each factor selection, and the optimal extraction technology was obtained by box-benhnken test design analysis.[Results] After analyzing the results, the optimal process was as follows: a time of 28.89 min and liquid/material ratio of 31.38∶ 1, the temperature was 40.74℃. In this way, NaNO 2-Al (NO 3) 3-NaOH was used as color developing agent, and the theoretical extraction of flavone in ginkgo leaf can reach 11.74 mg/g.[Conclusions] This method can be used to extract total flavonoids from G. biloba leaves with simple operation, low cost and good repeatability. 展开更多
关键词 GINKGO LEAF ULTRASOUND extraction Total FLAVONE Single factor Response method
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内蒙古气温变暖停滞对其影响因子变化的响应 预览
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作者 孙柏林 马龙 +5 位作者 冯起 刘廷玺 梁珑腾 李虹雨 周莹 柳杨 《中国环境科学》 EI CAS CSCD 北大核心 2019年第5期2131-2142,共12页
采用中心聚类、M-K检验等方法,以内蒙古地区为例,利用全球Pacific Decadal Oscillation(PDO)、Multivariate ENSO Index(MEI)等大空间尺度数据以及内蒙古及其周边70个气象站1951~2016年平均最低气温、平均气温、平均最高气温、风速、大... 采用中心聚类、M-K检验等方法,以内蒙古地区为例,利用全球Pacific Decadal Oscillation(PDO)、Multivariate ENSO Index(MEI)等大空间尺度数据以及内蒙古及其周边70个气象站1951~2016年平均最低气温、平均气温、平均最高气温、风速、大气压等站点数据,定性、定量揭示变暖停滞的变化特征及其对影响因子变化的响应.结果表明:研究区各分区3类气温在1981~1993年间发生升温突变,此后1998~2008年间陆续发生变暖停滞.不同类型气温在不同分区与各影响因子的相关性优劣有所不同,如平均最低气温与AMO、PDO、MEI、太阳总辐射、风速、大气压的相关性最好,平均气温次之,平均最高气温最差;西部区气温与AMO、PDO、MEI、太阳总辐射相关性较好,中部区气温则与AMO、风速相关性较好等.整体上,1990s~2000s,随各分区AMO上升驱缓、PDO处于正位相阶段但呈下降趋势或处于负位相时、MEI值与太阳总辐射下降、风速、大气压、相对湿度的持续下降/上升及之后的趋势转变,各分区气温发生变暖停滞,如当AMO开始整体进入上升趋缓阶段,风速持续减小8~13a,倾向率达到-0.26~-0.11m/(s·10a)时,平均气温发生变暖停滞.平均最低气温对3类影响因子变化的响应最敏感,平均气温次之.气温变暖停滞是多种影响因子共同作用的结果.本研究丰富了该方面研究成果,对气候变化研究及防灾减灾等有一定借鉴意义. 展开更多
关键词 气温 变暖停滞 响应 内蒙古
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Evaluation of SWAT Model performance on glaciated and non-glaciated subbasins of Nam Co Lake, Southern Tibetan Plateau, China
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作者 Muhammad ADNAN KANG Shi-chang +3 位作者 ZHANG Guo-shuai Muhammad Naveed ANJUM Muhammad ZAMAN ZHANG Yu-qing 《山地科学学报:英文版》 SCIE CSCD 2019年第5期1075-1097,共23页
This paper presents an assessment of the Soil and Water Assessment Tool(SWAT) on a glaciated(Qugaqie) and a non-glaciated(Niyaqu) subbasin of the Nam Co Lake. The Nam Co Lake is located in the southern Tibetan Plateau... This paper presents an assessment of the Soil and Water Assessment Tool(SWAT) on a glaciated(Qugaqie) and a non-glaciated(Niyaqu) subbasin of the Nam Co Lake. The Nam Co Lake is located in the southern Tibetan Plateau, two subbasins having catchment areas of 59 km~2 and 388 km~2, respectively. The scores of examined evaluation indices(i.e., R~2, NSE, and PBIAS) established that the performance of the SWAT model was better on the monthly scale compared to the daily scale. The respective monthly values of R~2, NSE, and PBIAS were 0.94, 0.97, and 0.50 for the calibration period while 0.92, 0.88, and -8.80 for the validation period. Glacier melt contribution in the study domain was simulated by using the SWAT model in conjunction with the Degree Day Melt(DDM) approach. The conjunction of DDM with the SWAT Model ensued improved results during both calibration(R~2=0.96, NSE=0.95, and PBIAS=-13.49) and validation (R~2=0.97, NSE=0.96, and PBIAS=-2.87) periods on the monthly time scale. Average contribution(in percentage) of water balance components to the total streamflow of Niyaqu and Qugaqie subbasins was evaluated. We found that the major portion(99.45%) of the streamflow in the Niyaqu subbasin was generated by snowmelt or rainfall surface runoff(SURF_Q), followed by groundwater(GW_Q, 0.47%), and lateral(LAT_Q, 0.06%) flows. Conversely, in the Qugaqie subbasin, major contributor to the streamflow(79.63%) was glacier melt(GLC_Q), followed by SURF_Q(20.14%), GW_Q(0.13%), and LAT_Q(0.089%). The contribution of GLC_Q was the highest(86.79%) in July and lowest(69.95%) in September. This study concludes that the performance of the SWAT model in glaciated catchment is weak without considering glacier component in modeling;however, it performs reasonably well in non-glaciated catchment. Furthermore, the temperature index approach with elevation bands is viable in those catchments where streamflows are driven by snowmelt. Therefore, it is recommended to use the SWAT Model in conjunction with DDM or energy base model to simulat 展开更多
关键词 SWAT MODEL NAM Co Lake DEGREE-DAY MELT MODEL Streamflow HYDROLOGICAL Response Unit
Sliding mode control design for oblique wing aircraft in wing skewing process
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作者 Ting YUE Zijian XU +1 位作者 Lixin WANG Tong WANG 《中国航空学报:英文版》 SCIE EI CAS CSCD 2019年第2期263-271,共9页
When the wing of Oblique Wing Aircraft(OWA) is skewed, the center of gravity, inertia and aerodynamic characteristics of the aircraft all significantly change, causing an undesirable flight dynamic response, affecting... When the wing of Oblique Wing Aircraft(OWA) is skewed, the center of gravity, inertia and aerodynamic characteristics of the aircraft all significantly change, causing an undesirable flight dynamic response, affecting the flying qualities, and even endangering the flight safety. In this study,the dynamic response of an OWA in the wing skewing process is simulated, showing that the threeaxis movements of the OWA are highly coupled and present nonlinear characteristics during the wing skewing. As the roll control efficiency of the aileron decreases due to the shortened control arm in an oblique configuration, the all-moving horizontal tail is used for additional roll and the control allocation is performed based on minimum control energy. Given the properties of pitchroll-yaw coupling and control input and state coupling, and the difficulty of establishing an accurate aerodynamic model in the wing skewing process due to unsteady aerodynamic force, a multi-loop sliding mode controller is formulated by the time-scale separation method. The closed-loop simulation results show that the asymmetric aerodynamics can be balanced and that the velocity and altitude of the aircraft maintain stable, which means that a smooth transition is obtained during the OWA’s wing skewing. 展开更多
关键词 DECOUPLING Dynamic response OBLIQUE WING AIRCRAFT Sliding mode control WING SKEWING PROCESS
Seismic performance evaluation of typical dampers designed by Chinese building code 预览
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作者 Guo Wei Wu Jun +2 位作者 Hu Yao Li Yunsong Yang T.Y. 《地震工程与工程振动:英文版》 SCIE EI CSCD 2019年第2期433-446,共14页
Adding dampers is a commonly adopted seismic risk mitigation strategy for modern buildings, and the corresponding design procedure of dampers has been well established by the Chinese Building Code. Even though all typ... Adding dampers is a commonly adopted seismic risk mitigation strategy for modern buildings, and the corresponding design procedure of dampers has been well established by the Chinese Building Code. Even though all types of dampers are designed by the same procedure, actual seismic performance of the building may differ from one to the others. In this study, a nine-story benchmark steel building is established, and three different and typical types of dampers are designed according to the Chinese Building Code to realize structural vibration control under strong earthquake excitation. The seismic response of the prototype building equipped with a viscoelastic damper, viscous damper and buckling-restrained brace(BRB) subjected to 10 earthquake records are calculated, and Incremental Dynamic Analysis(IDA) is performed to describe progressive damage of the structure under increasing earthquake intensity. In the perspective of fragility, it shows that the viscoelastic damper has the highest collapse margin ratio(CMR), and the viscous damper provides the best drift control. Both the BRB and viscoelastic dampers can effectively reduce the floor acceleration responses in the mid-rise building. 展开更多
关键词 CHINESE building design code viscoelastic DAMPER VISCOUS DAMPER buckling-restrained BRACE seismic response FRAGILITY analysis
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