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Traditional Chinese medicine nursing protocols for chronic renal failure 预览
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作者 Editorial Board of Nursing of Integrated Traditional Chinese and Western Medicine 《中西医结合护理(中英文)》 2019年第3期263-270,共8页
Chronic renal failure (CRF) is defined as the loss of renal function over a period of several years,finally progressing into the end-stage renal disease (ESRD).Nowadays,there are no effective methods to alleviate the ... Chronic renal failure (CRF) is defined as the loss of renal function over a period of several years,finally progressing into the end-stage renal disease (ESRD).Nowadays,there are no effective methods to alleviate the process from the initial CRF to ESRD.In clinic,the integrated therapy of traditional Chinese and western medicine is frequently adopted for CRF in combination with hemodialysis,but in the process of treatment,traditional Chinese medicine (TCM) nursing plays a key role.This article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of CRF in order to further develop the advantages of TCM,improve its efficacy and standardized its nursing behavior. 展开更多
关键词 chronic RENAL failure END-STAGE RENAL disease EDEMA CUTANEOUS PRURITUS traditional Chinese medicine NURSING syndrome differentiation
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Multimodality-imaging manifestations of primary renal-allograft synovial sarcoma: First case report and literature review 预览
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作者 Rui-Fang Xu En-Hui He +3 位作者 Zhan-Xiong Yi Jun Lin Yan-Ning Zhang Lin-Xue Qian 《世界临床病例杂志》 2019年第13期1677-1685,共9页
BACKGROUND Primary renal synovial sarcoma (PRSS) is an extremely rare tumor with a poor prognosis. Its imaging and immunohistochemical characteristics may overlap with other renal tumors, which renders its early diagn... BACKGROUND Primary renal synovial sarcoma (PRSS) is an extremely rare tumor with a poor prognosis. Its imaging and immunohistochemical characteristics may overlap with other renal tumors, which renders its early diagnosis in a dilemma. The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques. Cases of primary renal synovial sarcoma have been previously reported in the literature. However, to our knowledge, primary renal allograft synovial sarcoma was never described. CASE SUMMARY A 43-year-old male patient who underwent kidney transplantation 9 months ago came to our hospital for regular follow-up. Traditional ultrasonography revealed multiple hypo-echo neoplasms in the renal allograft. Contrast-enhanced computed tomography (CECT) showed slightly hyper-density masses with slow homogeneous enhancement. Ultrasound-guided biopsy was conducted for accurate pathological diagnosis. The neoplasms were diagnosed as synovial sarcoma by pathological, immunohistochemical, and genetic analyses. Positron emission tomography/CT showed no evidence of metastasis. At approximately one week post biopsy, contrast-enhanced ultrasound was conducted to eliminate active hemorrhage. One month later, CECT showed that the biggest neoplasm grew from 3.3 cm to 5.7 cm in diameter. Parametric imaging was conducted with SonoLiver CAP to conduct further quantitative analysis, which showed that the enhancement pattern was heterogeneous hyper-vascular enhancement. Radical surgical resection of the whole renal allograft and ureter was conducted without additional adjuvant chemotherapy or external radiotherapy. Anlotinib was chosen for targeted therapy with a good response. CONCLUSION We propose multimodality imaging for accurate diagnosis of renal allograft synovial sarcoma especially when it is formed by spindle-shaped cells. 展开更多
关键词 RENAL ALLOGRAFT Multimodality-imaging RENAL SYNOVIAL SARCOMA Ultrasonography Computed tomography Case report
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Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii
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作者 Na Li Yue Guan +4 位作者 Yan-Ming Tian Hui-Jie Ma Xiangjian Zhang Yi Zhang Sheng Wangb 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第1期79-90,共12页
Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was in... Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was induced by the 2-kidney-1-clip method(2 K1 C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. The arterial blood pressure(ABP), heart rate(HR), and renal sympathetic nerve activity(RSNA) were measured before and after microinjection of L-arginine into the nucleus tractus solitarii(NTS) in anesthetized rats.Evoked excitatory postsynaptic currents(eEPSCs) and spontaneous EPSCs(sEPSCs) were recorded in anterogradely-labeled NTS neurons receiving baroreceptor afferents. We measured the protein expression of neuronal nitric oxide synthase(nNOS) and endothelial NOS(eNOS) in the NTS. The results showed that the ABP in RVH rats was significantly lower after CIHH treatment. The inhibition of ABP, HR, and RSNA induced by L-arginine was less in RVH rats than in sham rats, and greater in the CIHHtreated RVH rats than the untreated RVH rats. The eEPSC amplitude in NTS neurons receiving baroreceptor afferents was lower in the RVH rats than in the sham rats and recovered after CIHH. The protein expression of nNOS and e NOS in the NTS was lower in the RVH rats than in the sham rats and this decrease was reversed by CIHH. In short, CIHH treatment decreases ABP in RVH rats via upregulating NOS expression in the NTS. 展开更多
关键词 Chronic intermittent hypobaric hypoxia RENAL VASCULAR HYPERTENSION Nitric oxide RENAL SYMPATHETIC nerve activity EXCITATORY POSTSYNAPTIC current
Rituximab in kidney disease and transplant 预览
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作者 Kajal Chauhan Anita A. Mehta 《动物模型与实验医学(英文)》 CSCD 2019年第2期76-82,共7页
Rituximab is a chimeric monoclonal antibody that binds to CD20 antigen of B‐cells. It depletes the level of mature B‐cells by various mechanisms such as mediation of antibody‐ dependent cellular cytotoxicity, compl... Rituximab is a chimeric monoclonal antibody that binds to CD20 antigen of B‐cells. It depletes the level of mature B‐cells by various mechanisms such as mediation of antibody‐ dependent cellular cytotoxicity, complement‐dependent cytotoxicity, and B‐cell apoptosis. Rituximab is a USFDA approved drug for clinical use in non‐Hodgkin's B‐cell lymphoma (NHL), rheumatoid arthritis, chronic lymphocytic leukemia (CLL), granulomatosis with polyangiitis and pemphigus vulgaris. It is also known for its “off label” use in renal disease and renal transplant worldwide. However, the exact mechanisms by which it exerts its effect in the aforementioned condition remain unclear but may be related to its long‐term effects on plasma cell development and the impact on B‐cell modulation of T cell responses. This review discusses the current use of rituximab in renal disease and renal transplantation, and its potential role in novel therapeutic protocols. 展开更多
关键词 RENAL DISEASES RENAL TRANSPLANT RITUXIMAB
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Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension
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作者 Jun-Hong Ren Na Ma +9 位作者 Si-Yu Wang You-Jing Sun Yue-Wei Zhang Fa-Jin Guo Yong-Jun Li Tian-Hui Li Hu Ai Wen-Duo Zhang Peng Li Wei-Hua Ma 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期63-68,共6页
Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP.Thus... Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP.Thus,this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Methods:This will be a single-center diagnostic study with a sample size of 440.Patients with chronic kidney disease (CKD) and suspected of having resistant hypertension will be eligible.Patients with Stages 1–3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA).Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be compared.Moreover,all patients will also undergo radionuclide imaging.The diagnostic value for RAS will be assessed by the receiver operating characteristic curve,including the accuracy,sensitivity,specificity,positive predictive values,negative predictive values,and area under the ROC.Pearson correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. Conclusion:The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension. 展开更多
关键词 RENOVASCULAR hypertension CONTRAST-ENHANCED ultrasound RENAL artery stenosis RENAL MICROVASCULAR perfusion
姜黄素后处理肢体缺血再灌注肾损伤模型大鼠基质金属蛋白酶9及基质金属蛋白酶组织抑制因子1平衡的变化 预览
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作者 邹海波 孙晓峰 《中国组织工程研究》 CAS 北大核心 2019年第23期3643-3648,共6页
背景:姜黄素预处理可减轻肢体缺血再灌注对肾脏的损伤,但姜黄素后处理是否对肾脏损伤有保护作用及其机制目前研究甚少。目的:探讨大鼠肢体缺血再灌注肾组织损伤时姜黄素后处理对基质金属蛋白酶9/基质金属蛋白酶组织抑制因子1平衡的影响... 背景:姜黄素预处理可减轻肢体缺血再灌注对肾脏的损伤,但姜黄素后处理是否对肾脏损伤有保护作用及其机制目前研究甚少。目的:探讨大鼠肢体缺血再灌注肾组织损伤时姜黄素后处理对基质金属蛋白酶9/基质金属蛋白酶组织抑制因子1平衡的影响。方法:成年雄性SD大鼠80只由中国医科大学实验室中心提供。实验方案经沈阳医学院附属中心医院动物实验伦理委员会批准。采用随机数字表法,将80只SD大鼠分为4组(n=20):假手术组、缺血再灌注组、姜黄素后处理组和地塞米松组。除假手术组外,其余大鼠采用夹闭双侧股动脉4h,再灌注4h的方法制备肢体缺血再灌注模型。在大鼠肢体缺血后4h,姜黄素后处理组经腹腔注射姜黄素200mg/kg,地塞米松组经腹腔注射地塞米松1.5mg/kg,假手术组、缺血再灌注组以等量生理盐水替代。于再灌注4h后,经颈动脉采集血样,检测肌酐、尿素氮;麻醉下取大鼠肾脏组织检测丙二醛水平,苏木精-伊红染色检测病理变化和肾小管间质半定量评分(SSRT);应用Westen blot法和RT-PCR法分别测定基质金属蛋白酶9、基质金属蛋白酶组织抑制因子1蛋白和核因子κB p65 mRNA含量,计算基质金属蛋白酶9/基质金属蛋白酶组织抑制因子1比值;应用ELESA法检测肺组织肿瘤坏死因子α和白细胞介素1β等炎性因子的水平。结果与结论:①与假手术组比较,缺血再灌注组血浆肌酐、尿素氮和丙二醛均升高(P<0.05);肾苏木精-伊红染色示肾小管扩张,管腔内可见管型,刷状缘消失、肾间质炎症细胞浸润等病变;SSRT升高(P<0.05);基质金属蛋白酶9、基质金属蛋白酶9/基质金属蛋白酶组织抑制因子1比值和核因子κB p65 mRNA含量均升高(P<0.05);肿瘤坏死因子α和白细胞介素1β炎性因子释放增加(P<0.05);②与缺血再灌注组比较,姜黄素后处理组血浆肌酐、尿素氮和丙二醛降低(P<0.05);肾组织炎性细胞浸 展开更多
关键词 姜黄素 缺血再灌注 姜黄素后处理 基质金属蛋白酶9 基质金属蛋白组织抑制因子1 肢体缺血再灌注 肾损伤模型
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Effects of RIRS and Mini-PCNL on liver and kidney function,endocrine changes and trauma in patients with upper ureteral calculi
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作者 Jin-Cheng Yin Jian-Hua Chen +1 位作者 Yan-Qing Gu Hong-Xin Liu 《海南医科大学学报(英文版)》 2019年第3期44-47,共4页
Objective: To investigate the effects of retrograde intrarenal surgery (RIRS) and Mini-percutaneous nephroscope lithoipsy (Mini-PCNL) on liver and kidney function, endocrine changes and trauma in patients with upper u... Objective: To investigate the effects of retrograde intrarenal surgery (RIRS) and Mini-percutaneous nephroscope lithoipsy (Mini-PCNL) on liver and kidney function, endocrine changes and trauma in patients with upper ureteral calculi. Methods: 100 patients with upper ureteral calculi admitted to our hospital from March 2016 to February 2018 were selected. They were randomly divided into observation group (RIRS group) and control group (Mini-PCNL group), with 50 cases in each group. The observation group was given RIRS, while the control group was given Mini-PCNL. At the same time, the expression levels of the liver function [including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma transpeptidase (gamma-GT)], renal function [including urea nitrogen (BUN) and serum creatinine (Scr) levels], endocrine changes [including corticotropin (ACTH), cortisol (Cor), norepinephrine (NE)] and trauma related indexes [Including soluble vascular cell adhesion molecule-1 (sVCAM-1) and erythrocyte sedimentation rate (ESR)] were analyzed and compared between the two groups. Results: There was no significant difference in ALT, AST, γ-GT, BUN and Scr before and after operation between the two groups. The difference was not statistically significant (P>0.05). After operation, the levels of ACTH (27.37±3.29) pg/mL, Cor (150.09±18.47) ng/mL, NE (165.48±26.74) ug/L and sVCAM-1, (596.55±56.24) ng/mL in RIRS group were significantly lower than those in Mini-PCNL group ((38.42±4.33) pg/mL, (222.37±28.70) ng/mL, (287.26±25.29) ug/L and (820.62±72) mL)The differences were statistically significant (P<0.05). While the ESR level in RIRS group (8.29±0.63) mm/h was significantly higher than that in Mini-PCNL group (7.16±0.68) mm/h, and the differences were statistically significant (P<0.05). Conclusions: There is no significant difference in the liver and renal function between RIRS and Mini-PCNL in the treatment of upper ureteral calculi. RIRS can better improve the endocrine status of patients and reduce the 展开更多
关键词 Upper ureteral CALCULI Liver FUNCTION RENAL FUNCTION ENDOCRINE TRAUMA
Effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy
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作者 Jun Li Xiao-Hong Zhang 《海南医科大学学报(英文版)》 2019年第3期31-35,共5页
Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy trea... Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy treated in our hospital between February 2015 and April 2017 were chosen and divided into two groups by random number table, observation group received Qishen Yiqi Drop Pill combined with conventional therapy and control group accepted conventional therapy. The renal function indexes, cytokine contents and oxygen free radical generation were compared before treatment and 3 months after treatment. Results:Urine UREA levels as well as serum β2 microglobulin (β2-MG), cystatin C (CysC), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), stromal cell-derived factor-1 (SDF-1), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) contents of both groups were significantly lower while superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) contents were significantly higher after treatment, and urine UREA level as well as serum β2-MG, CysC, TNF-α, IL-6, SDF-1, IL-17, TGF-β1, MDA and 8-iso-PGF2α contents of observation group after treatment was significantly lower than those of control group while SOD and T-AOC contents were significantly higher than those of control group. Conclusion: Adjuvant Qishen Yiqi Drop Pill therapy can improve the renal function and reduce the inflammatory response and oxidative stress response in early diabetic nephropathy. 展开更多
关键词 DIABETIC NEPHROPATHY Qishen Yiqi DROP PILL Renal function Inflammatory RESPONSE Oxidative stress RESPONSE
Hemorrhagic blisters in fulminant Aeromonas hydrophila bacteremia: Case report and literature review
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作者 Yao-Tien Chang Sung-Yuan Hu Che-An Tsai 《亚太热带医药杂志:英文版》 SCIE CAS 2019年第2期91-94,共4页
The Aeromonas species, belonging to the family Aeromonadaceae, are opportunistic pathogens found in humans with an incidence rate of 76 cases per million inhabitants in Southern Taiwan.The incidence of Aeromonas septi... The Aeromonas species, belonging to the family Aeromonadaceae, are opportunistic pathogens found in humans with an incidence rate of 76 cases per million inhabitants in Southern Taiwan.The incidence of Aeromonas septicemia is relatively low, accounting for less than 15% of cases.Patients diagnosed with Aeromonas hydrophila bacteremia who were presented with skin blisters and septic shock have been reported to have a mortality rate of 100%.Aeromonas infection must be considered in the differential diagnosis of gangrene-like tissue damage or skin lesions in patients with end-stage renal disease, due to the potential sources of infections.A 49-year-old Taiwanese diabetic woman with end-stage renal disease had underwent regular hemodialysis.She was referred to our hospital due to a one-day course of fever, dyspnea, hypotension, and fulminant hemorrhagic blisters covering her whole body.A physical examination uncovered multiple hemorrhagic blisters, along with a ruptured blister over the lower left leg.Laboratory tests revealed an elevation of liver enzymes, impaired renal function, lactatemia, and high anion-gap metabolic acidosis.Cultures of both blood and hemorrhagic blister fluid grew Aeromonas hydrophila.However, she experienced persistent shock despite aggressive intravenous fluid, empiric antibiotics, and inotropic agents with norepinephrine and dopamine.Early diagnosis and prompt management using intravenous fluids, antibiotics and surgical debridement is recommended in order to improve a patient’s survival rate. 展开更多
关键词 Aeromonas HYDROPHILA BACTEREMIA End-stage renal disease HEMORRHAGIC BLISTER
A rare presentation of spontaneous atheroembolic renal disease: A case report 预览
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作者 Paramarajan Piranavan Ashna Rajan +1 位作者 Vishal Jindal Ashish Verma 《世界肾病学杂志:英文版》 2019年第3期67-74,共8页
BACKGROUND Atheroembolic renal disease (AERD) is caused by occlusion of the small renal arteries from embolized cholesterol crystals arising from ulcerated atherosclerotic plaques. This usually manifests as isolated r... BACKGROUND Atheroembolic renal disease (AERD) is caused by occlusion of the small renal arteries from embolized cholesterol crystals arising from ulcerated atherosclerotic plaques. This usually manifests as isolated renal disease or involvement from systemic atheroembolic disease. Here we report a case of AERD that responded well to steroid therapy. CASE SUMMARY A 62-year-old woman with a history of hypertension and stage IIIa chronic kidney disease was referred for rapidly worsening renal function over a 4-mo period. She complained of swollen legs, dyspnea on exertion, and two episodes of epistaxis about a month prior to admission. She reported no history of invasive vascular procedures, use of radio contrast agents, or treatment with anticoagulants or thrombolytic agents. Urinalysis showed a few red blood cells and granular casts. Serology was positive for cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA). Non-contrast-enhanced computed tomography of the chest, abdomen, and pelvis showed diffuse atherosclerotic changes in the aortic arch. Thus, c-ANCA-associated vasculitis was suspected, and the patient was started on pulse intravenous methylprednisolone. Her renal biopsy showed evidence of AERD. She was discharged with oral prednisone, and her renal function continued to improve during the initial follow-up. CONCLUSION In cases of non-vasculitis-associated ANCA, a high degree of clinical suspicion is required to pursue the diagnosis of spontaneous AERD in patients with clinical or radiological evidence of atherosclerotic burden. Although no specific treatment is available, the potential role of statins and steroids requires exploration. 展开更多
关键词 Atheroembolic RENAL DISEASE Antineutrophil CYTOPLASMIC ANTIBODIES associated VASCULITIS Chronic kidney DISEASE Case report
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甲壳质酶蛋白40对肾结核的诊断效能及关系研究 预览
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作者 陈怀安 刘硕 +4 位作者 李秀君 王哲 张潮 李凤岐 苗文隆 《中国现代医学杂志》 CAS 2019年第14期110-113,共4页
目的研究血清甲壳质酶蛋白40(YKL-40)水平对肾结核的诊断效能,分析其与肾结核的关系。方法选取2012年8月—2017年8月河北北方学院附属第一医院收治的46例肾结核患者作为结核组,另选取同期来院体检的46例健康志愿者作为对照组。观察两组... 目的研究血清甲壳质酶蛋白40(YKL-40)水平对肾结核的诊断效能,分析其与肾结核的关系。方法选取2012年8月—2017年8月河北北方学院附属第一医院收治的46例肾结核患者作为结核组,另选取同期来院体检的46例健康志愿者作为对照组。观察两组血清YKL-40水平,分析YKL-40对肾结核的诊断价值。结果研究组血清YKL-40水平高于对照组(P<0.05);病变组织YKL-40水平高于周围健康组织(P<0.05)。实时荧光定量聚合酶链反应(qRT-PCR)检出肾结核阳性患者30例(32.61%),YKL-40检出阳性患者44例(47.83%),YKL-40检出肾结核阳性率高于PCR(P<0.05)。YKL-40检测ROC曲线下面积为0.930,PCR检测ROC曲线下面积为0.790,YKL-40检测ROC曲线下面积大于PCR(P<0.05)。结论YKL-40检测对肾结核诊断效能较高。 展开更多
关键词 结核 诊断 ROC曲线
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Clinical factors associated with hepatitis B screening and vaccination in high-risk adults 预览
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作者 Rotimi Ayoola Sebastian Larion +1 位作者 David M Poppers Renee Williams 《世界肝病学杂志:英文版(电子版)》 2019年第1期86-98,共13页
BACKGROUND Hepatitis B virus is a viral infection that can lead to acute and/or chronic liver disease, and hepatocellular carcinoma (HCC). Hepatitis B vaccination is 95% effective in preventing infection and the devel... BACKGROUND Hepatitis B virus is a viral infection that can lead to acute and/or chronic liver disease, and hepatocellular carcinoma (HCC). Hepatitis B vaccination is 95% effective in preventing infection and the development of chronic liver disease and HCC due to hepatitis B. In 2011, the Centers for Disease Control updated their guidelines recommending that adults at high-risk for hepatitis B infection be vaccinated against hepatitis B including those with diabetes mellitus (DM). We hypothesize that adults at high-risk for hepatitis B infection are not being adequately screened and/or vaccinated for hepatitis B in a large urban healthcare system. AIM To investigate clinical factors associated with Hepatitis B screening and vaccination in patients at high-risk for Hepatitis B infection. METHODS We conducted a retrospective review of 999 patients presenting at a large urban healthcare system from 2012-2017 at high-risk for hepatitis B infection. Patients were considered high-risk for hepatitis B infection based on hepatitis B practice recommendations from the Center for Disease Control. Medical history including hepatitis B serology, concomitant medical diagnoses, demographics, insurance status and social history were extracted from electronic health records. Multivariate logistic regression was used to identify clinical risk factors independently associated with hepatitis B screening and vaccination. RESULTS Among the 999 patients, 556 (55.7%) patients were screened for hepatitis B. Of those who were screened, only 242 (43.5%) patients were vaccinated against hepatitis B. Multivariate regression analysis revealed end-stage renal disease [odds ratio (OR): 5.122; 2.766-9.483], alcoholic hepatitis (OR: 3.064; 1.020-9.206), and cirrhosis or end-stage liver disease (OR: 1.909; 1.095-3.329); all P < 0.05 were associated with hepatitis B screening, while age (OR: 0.785; 0.680-0.906), insurance status (0.690; 0.558-0.854), history of DM (OR: 0.518; 0.364-0.737), and human immunodeficiency virus (OR: 0.443; 0.273-0.718); 展开更多
关键词 Health prevention VACCINATION Hepatitis B VIRUS SCREENING Diabetes mellitus Cirrhosis END-STAGE renal disease Human IMMUNODEFICIENCY VIRUS Intravenous drug users
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Early initiation renal replacement therapy for fluid management to reduce central venous pressure is more conducive to renal function recovery in patients with acute kidney injury
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作者 Zhi-Qun Xing Da-Wei Liu +4 位作者 Xiao-Ting Wang Yun Long Hong-Min Zhang Pan Pan Long-Xiang Su 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第11期1328-1335,共8页
Background:Acute kidney injury (AKI) is a serious complication in critically ill patients with septic shock treated in the intensive care unit. Renal replacement therapy (RRT) is a treatment for severe AKI;however, th... Background:Acute kidney injury (AKI) is a serious complication in critically ill patients with septic shock treated in the intensive care unit. Renal replacement therapy (RRT) is a treatment for severe AKI;however, the time of initiation of RRT and factors that affect the recovery of kidney function remains unclear. This study was to explore whether early initiation of RRT treatment for fluid management to reduce central venous pressure (CVP) can help to improve patients5 kidney function recovery. Methods: A retrospective analysis of septic patients who had received RRT treatment was conducted. Patients received RRT either within 12 h after they met the diagnostic criteria of renal failure (early initiation) or after a delay of 48 h if renal recovery had not occurred (delayed initiation). Parameters such as patients5 renal function recovery at discharge, fluid balance, and levels of CVP were assessed. Results: A total of 141 patients were eligible for enrolment: 40.4% of the patients were in the early initiation group (57 of 141 patients), and 59.6% were in the delayed initiation group (84 of 141 patients). There were no significant differences in the characteristics at baseline between the two groups, and there were no differences in 28-day mortality between the two groups (χ^2 = 2.142, P = 0.143);however, there was a significant difference in the recovery rate of renal function between the two groups at discharge (χ^2 = 4.730, P < 0.001). More importantly, early initiation of RRT treatment and dehydration to reduce CVP are more conducive to the recovery of renal function in patients with AKI. Conclusion: Compared with those who received delayed initiation RRT, patients who received early-initiation RRT for dehydration to reduce CVP have enhanced kidney function recovery. 展开更多
关键词 SEPSIS Acute kidney injury RENAL REPLACEMENT therapy Central VENOUS pressure
Effects of flexible ureteroscopy combined with percutaneous nephrolithotomy on inflammatory immune indexes and related factors in patients with renal calculi
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作者 Wen-Biao Peng Xin Wang +1 位作者 Zhi-Bin Zhong Ya-Wen Xu 《海南医科大学学报(英文版)》 2019年第1期22-26,共5页
Objective:To explore the effects of flexible ureteroscopy combined with percutaneous nephrolithotomy on inflammatory immune indexes and related factors in patients with renal calculi.Methods: From December 2016 to Nov... Objective:To explore the effects of flexible ureteroscopy combined with percutaneous nephrolithotomy on inflammatory immune indexes and related factors in patients with renal calculi.Methods: From December 2016 to November 2017, 97 patients with renal calculi were selected and divided into control group (48 cases) and observation group (49 cases), the control group was treated with percutaneous nephrolithotomy. On the basis of the treatment of the control group, the observation group was treated with ureteroscopic lithotripsy. The changes of inflammatory mediators, immune index, thyroxine (TH), urokinase (UK) and renal function were compared between the two groups before and after treatment.Results: After treatment, the levels of prostaglandin E2 (PGE2), substance P (SP), nitric oxide (NO) and lipid peroxide (LPO) in the two groups were significantly higher than those before treatment, and the levels of PGE2, SP, NO and LPO in the control group were significantly higher than those in the observation group;the levels of CD4+, CD4+/CD8+ in the two groups were significantly lower than those before treatment, but the levels of CD8+ were significantly higher than those before treatment, and the levels of CD4+, CD4+/CD8+in the control group were significantly lower than those in the observation group, and the levels of CD8+ were significantly higher than those in the observation group;the levels of TH in the two groups were significantly lower than those before treatment, but the levels of UK were significantly higher than those before treatment, and the levels of TH in the observation group were significantly lower than those in the control group, and the levels of UK were significantly higher than those in the control group;the levels of urea nitrogen (BUN), serum creatinine (Scr), cystatin C (CysC) in the two groups were significantly higher than those before treatment, and the levels of BUN, Scr, CysC in the control group were significantly higher than those in the observation group. Conclusions:The combination of 展开更多
关键词 URETEROSCOPY PERCUTANEOUS NEPHROLITHOTOMY RENAL CALCULI Inflammatory immunity Related factors
LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21signaling
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作者 Liangsong Zhu Jianfeng Wang +5 位作者 Wen Kong Jiwei Huang Baijun Dong Yiran Huang Wei Xue Jin Zhang 《药学学报:英文版》 CSCD 2019年第2期324-334,共11页
Histone lysine-specific demethylase 1(LSD1) has been implicated in the disease progression of several types of solid tumors. This study provides the first evidence showing that LSD1 overexpression occurred in 62.6%(22... Histone lysine-specific demethylase 1(LSD1) has been implicated in the disease progression of several types of solid tumors. This study provides the first evidence showing that LSD1 overexpression occurred in 62.6%(224/358) of clear cell renal cell carcinomas(ccRCC). LSD1 expression was associated with the progression of ccRCC, as indicated by TNM stage(P ? 0.006), especially tumor stage(P ? 0.017) and lymph node metastasis(P ? 0.030). High LSD1 expression proved to be an independent prognostic factor for poor overall survival(Po0.001) and recurrence-free survival(Po0.001) of ccRCC patients. We further show that LSD1 inhibition by siRNA knockdown or using the small molecule inhibitor SP2509 suppressed the growth of ccRCC in vitro and in vivo. Mechanistically, inhibition of LSD1 decreased the H3 K4 demethylation at the CDKN1 A gene promoter, which was associated with P21 upregulation and cell cycle arrest at G1/S in ccRCC cells. Our findings provide new mechanistic insights into the role of LSD1 in cc RCC and suggest the therapeutic potential of LSD1 inhibitors in ccRCC treatment. 展开更多
关键词 CLEAR CELL RENAL CELL carcinoma LSD1 PROGNOSIS PROLIFERATION P21
Malignancy of renal angiomyolipoma from tuberous sclerosis complex with TSC2 mutation
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作者 Yu-Jing Huang Zong-Pei Jiang +4 位作者 Yu-Ping Chen Jin-Quan Wu Jia-Li Huang Yan-Qiang Chen Meng-Jun Liang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期103-105,共3页
To the Editor:Tuberous sclerosis complex (TSC),with the birth incidence of 1:6000,[1] is an autosomal dominant inherited,multi-system disorder characterized by cellular hyperplasia and tissue dysplasia,among which,ren... To the Editor:Tuberous sclerosis complex (TSC),with the birth incidence of 1:6000,[1] is an autosomal dominant inherited,multi-system disorder characterized by cellular hyperplasia and tissue dysplasia,among which,renal angiomyolipoma (AML) is one common comorbidity.However,malignancy of renal AML is rare.Herein,we shared a case of malignancy of renal AML from TSC in a young man. 展开更多
关键词 MALIGNANCY RENAL ANGIOMYOLIPOMA tuberous SCLEROSIS COMPLEX TSC2 MUTATION
Radiologic features of Castleman’s disease involving the renal sinus: A case report and review of the literature 预览
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作者 Xiao-Wan Guo Xu-Dong Jia +4 位作者 Shan-Shan Shen Hong Ji Ying-Min Chen Qian Du Shu-Qian Zhang 《世界临床病例杂志》 2019年第8期1001-1005,共5页
BACKGROUND We present a rare case of plasma cell type of Castleman’s disease (CD) involving only the right renal sinus in a 65-year-old woman with a duplex collecting system (DCS). CASE SUMMARY The patient presented ... BACKGROUND We present a rare case of plasma cell type of Castleman’s disease (CD) involving only the right renal sinus in a 65-year-old woman with a duplex collecting system (DCS). CASE SUMMARY The patient presented with a right renal sinus lesion after renal ultrasonography. Subsequent abdominal enhanced computed tomography (CT) and magnetic resonance imaging (MRI) of the kidneys showed DCS and a soft tissue mass with mild enhancement at the lower right renal sinus. The lesion was suspected to be a malignant renal pelvic carcinoma. Hence, the patient underwent a right radical nephrectomy. Histological examination revealed hyperplastic lymphoid follicles in the renal sinus. A detailed review of the patient’s CT and MRI images and a literature review suggested that the lesion was hypointense on T2- weighted images and hyperintense on diffusion-weighted image manifestations, and showed mild enhancement, which distinguished the plasma cell type of CD from many other renal sinus lesions. Furthermore, peripelvic soft tissue masses with a smooth internal surface of the renal pelvis were on imaging findings, which suggests that the urinary tract epithelial system is invulnerable and can be used to differentiate the plasma cell type of CD from malignant lymphoma with a focally growth pattern to some extent. CONCLUSION Preoperative diagnosis is often difficult in such cases, as plasma cell type of CD involving only the right kidney is exceedingly rare. However, heightened awareness of this disease entity and its radiographic presentations may alert one to consider this diagnosis. 展开更多
关键词 DUPLEX COLLECTING system Castleman's disease Plasma cell type RENAL SINUS Image Case report
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异丙酚预先给药对肝缺血再灌注小鼠肾损伤时Drp1 Ser637去磷酸化的影响
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作者 于向洋 贾莉莉 +1 位作者 喻文立 杜洪印 《中华麻醉学杂志》 CAS CSCD 北大核心 2019年第1期113-116,共4页
目的评价异丙酚预先给药对肝缺血再灌注小鼠肾损伤时动力相关蛋白1(Drp1)Ser637去磷酸化的影响。方法SPF级健康雄性C57小鼠30只,体重20~25 g,采用随机数字表法分为3组(n=10):假手术组(S组)、肝缺血再灌注组(HI/R组)和异丙酚预先给药组(P... 目的评价异丙酚预先给药对肝缺血再灌注小鼠肾损伤时动力相关蛋白1(Drp1)Ser637去磷酸化的影响。方法SPF级健康雄性C57小鼠30只,体重20~25 g,采用随机数字表法分为3组(n=10):假手术组(S组)、肝缺血再灌注组(HI/R组)和异丙酚预先给药组(P组)。建立小鼠肝缺血再灌注模型。P组于术前30 min腹腔注射1%异丙酚30 mg/kg,S组和HI/R组腹腔注射等容量生理盐水。于再灌注6 h时经左心室采血检测血清尿素氮(BUN)及肌酐(Cr)水平,TUNEL染色法确定肾组织细胞凋指数亡,采用Western blot法检测肾组织Drp1、p-Drp1 Ser637、细胞色素c(Cyt-c)、cleaved caspase-3表达,透射电镜下观察细胞线粒体超微结构。结果与S组比较,HI/R组和P组血清BUN和Cr浓度、肾组织细胞凋亡指数升高,p-Drp1 Ser637表达下调,Cyt-c、cleaved caspase-3表达上调(P<0.05),电镜下部分线粒体肿胀并出现空泡变性,线粒体嵴排列不规律或断裂变短;与HI/R组比较,P组血清BUN和Cr浓度、肾组织细胞凋亡指数降低,p-Drp1 Ser637表达上调,Cyy-c、cleaved caspase-3表达下调(P<0.05),线粒体超微结构明显改善。3组肾组织Drp1表达差异无统计学意义(P>0.05)。结论异丙酚预先给药减轻肝缺血再灌注小鼠肾损伤的机制与抑制Drpl Ser637去磷酸化有关。 展开更多
关键词 二异丙酚 再灌注损伤 动力蛋白质类
Recurrent renal cell carcinoma leading to a misdiagnosis of polycystic liver disease: A case report 预览
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作者 Chen Liang Kazuhiro Takahashi +3 位作者 Masanao Kurata Shingo Sakashita Tatsuya Oda Nobuhiro Ohkohchi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第18期2264-2270,共7页
BACKGROUND Polycystic liver disease (PCLD) with a large cystic volume deteriorates the quality of life of patients through substantial effects on the adjacent organs, recurrent cyst infections, cyst rupture, and hemor... BACKGROUND Polycystic liver disease (PCLD) with a large cystic volume deteriorates the quality of life of patients through substantial effects on the adjacent organs, recurrent cyst infections, cyst rupture, and hemorrhage. Surgical or radiological intervention is usually needed to alleviate these symptoms. We report a rare case of the cystic metastasis of renal cell carcinoma (RCC), which was misdiagnosed as PCLD, as a result of the clinical and radiological similarity between these disorders. CASE SUMMARY A 74-year-old female who had undergone nephrectomy for papillary-type RCC (PRCC) was suffering from abdominal pain and the recurrent intracystic hemorrhage of multiple cysts in the liver. Imaging studies and aspiration cytology of the cysts showed no evidence of malignancy. With a diagnosis of autosomal dominant polycystic liver disease, the patient received hepatectomy for the purpose of mass reduction and infectious cyst removal. Surgery was performed without complications, and the patient was discharged on postoperative day 14. Postoperatively, the pathology revealed a diagnosis of recurrent PRCC with cystic formation. CONCLUSION This case demonstrates the importance of excluding the cystic metastasis of a cancer when liver cysts are observed. 展开更多
关键词 POLYCYSTIC liver DISEASE POLYCYSTIC kidney DISEASE CYSTIC metastasis Renal cell carcinoma Case report
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p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo
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作者 Limin Liu Peng Zhang +10 位作者 Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun 《分子细胞生物学报:英文版》 SCIE CAS CSCD 2019年第5期371-382,共12页
Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis... Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. 展开更多
关键词 RENAL tubulointerstitial FIBROSIS HYPOXIA cell cycle (G2/M) ARREST P53 HIF-lα TGF-β
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