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The process of retinal vascularization in retinopathy of prematurity after ranibizumab treatment in China
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作者 Qing-Yu Meng Yong Cheng +1 位作者 Ming-Wei Zhao Jian-Hong Liang 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1146-1150,共5页
AIM: To explore the process of retinal vascularization and risk factors for retinopathy of prematurity (ROP) treated with intravitreal ran ibizumab (IVR) as mono therapy.METHODS: Infants with type 1 ROP who received I... AIM: To explore the process of retinal vascularization and risk factors for retinopathy of prematurity (ROP) treated with intravitreal ran ibizumab (IVR) as mono therapy.METHODS: Infants with type 1 ROP who received IVR as primary treatment from August 2014 to October 2016 at Peking University People's HospitaPs Ophthalmology Department were included in the study. All eyes received 0.25 mg ranibizumab at initial treatment. Retinal vascularization was evaluated clinically. Potential risk factors were also recorded and examined.RESULTS: Retinal vascularization was completed in 126 eyes (62.7%), and retinal vascularization terminated in zone Ⅱ and zone Ⅲ with 16 eyes (7.9%) and 44 eyes (21.9%), respectively, after more than 1-year follow-up. In multivariate regression analysis, lower birth weight (BW), severity of ROP and repeated injections were found to be risk factors for peripheral avascular area (P<0.05).CONCLUSION: In our retrospective study, 29.8% of the ROP eyes treated with ranibizumab have peripheral avascular area at the last follow-up. Lighter BW and the severity of ROP are risk factors. Furthermore, repeated injections also increase the risk of retinal peripheral avascular area remaining in ROP patients. 展开更多
关键词 RETINAL VASCULARIZATION RETINOPATHY of PREMATURITY RANIBIZUMAB AVASCULAR RETINAL area
Elevated expression of TREK-TRAAK K2P channels in the retina of adult rd1 mice
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作者 Xiao-Tong Zhang Zhen Xu +4 位作者 Kang-Pei Shi Dian-Lei Guo Han Li Lei Wang Xiao-Bo Zhu 《国际眼科杂志:英文版》 SCIE CAS 2019年第6期924-929,共6页
AIM: To examine the expression of Twik-related K+ channel 1(TREK-1), Twik-related K+ channel 2(TREK-2), and Twik-related arachidonic acid-stimulated K+ channel(TRAAK) in the retina of adult rd1 mice and to detect the ... AIM: To examine the expression of Twik-related K+ channel 1(TREK-1), Twik-related K+ channel 2(TREK-2), and Twik-related arachidonic acid-stimulated K+ channel(TRAAK) in the retina of adult rd1 mice and to detect the protective roles of TREK-TRAAK two-pore-domain K+(K2P) channels against retinal degeneration.METHODS: Twenty-eight-day-old C57BL/6J mice and 28-day-old rd1 mice were used in this study. Retinal protein, retinal RNA, and embedded eyeballs were prepared from these two groups of mice. Real-time quantitative polymerase chain reaction and Western blot analyses were used to assess the gene transcription and protein levels, respectively. Retinal structures were observed using hematoxylin and eosin(H&E) staining. Immunohistochemistry was utilized to observe the retinal localization of TREK-TRAAK channels. Current changes in retinal ganglion cells(RGCs) after activation of TREK-TRAAK channels were examined using a patchclamp technique. RESULTS: Compared with C57BL/6J mice, rd1 mice exhibited significantly higher retinal mRNA and protein expression levels of TREK-1, TREK-2, and TRAAK channels. In both groups, immunohistochemistry showed expression of TREK-TRAAK channels in retinal layers. After addition of the TREK-TRAAK channel agonist arachidonic acid(AA), whole-cell voltage step evoked currents were significantly higher in RGCs from rd1 mice than in RGCs from control C57BL/6J mice, suggesting that TREK-TRAAK channels were opened in RGCs from rd1 mice. CONCLUSION: TREK-TRAAK K2P channels’ expression is increased in adult rd1 mice. AA induced the opening of TREK-TRAAK K2P channels in adult rd1 mice and may thus counterbalance depolarization of RGCs and protect the retina from excitotoxicity. TREK-TRAAK channels may play a protective role against retinal degeneration. 展开更多
关键词 TREK-TRAAK CHANNELS arachidonic acid RETINAL GANGLION cells RETINAL DEGENERATION
Abrupt visual loss during anti-vascular endothelial growth factor treatment for type 3 neovascularization
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作者 Jae Hui Kim Young Suk Chang +2 位作者 Jong Woo Kim Chul Gu Kim Dong Won Lee 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期480-487,共8页
AIM: To investigate the incidence of abrupt visual loss and its associated factors, during anti-vascular endothelial growth factor(VEGF) treatment for type 3 neovascularization.METHODS: This retrospective study includ... AIM: To investigate the incidence of abrupt visual loss and its associated factors, during anti-vascular endothelial growth factor(VEGF) treatment for type 3 neovascularization.METHODS: This retrospective study included 137 eyes that were newly diagnosed with type 3 neovascularization. All eyes were treated with anti-VEGF therapy. Abrupt visual loss was defined as loss of 5 or more lines in best-corrected visual acuity(BCVA) in comparison to the previous visit. The incidence and timing of abrupt visual loss as well as the factors associated with it, were determined. In addition, the BCVA at the final follow-up was compared between the eyes with and those without abrupt visual loss.RESULTS: The mean follow-up period was 42.4±18.9 mo after diagnosis, and abrupt visual loss was noted in 22 eyes(16.1%) at a mean of 19.6±13.9 mo. Abrupt visual loss was found to be associated with subretinal hemorrhage in 11 eyes(50.0%), development of or increase in the height of pigment epithelial detachment with fluid in 8 eyes(36.4%), and tears in the retinal pigment epithelium in 3 eyes(13.6%). The logarithm of minimum angle of resolution(logMAR) mean BCVA at the final follow-up was 2.07±0.67(Snellen equivalents: 20/2349) and 1.00±0.55(20/200) in eyes with and without abrupt visual loss, respectively. BCVA was significantly worse in the eyes with abrupt visual loss(P<0.001).CONCLUSION: Abrupt visual loss is noted in 16.1% of patients with type 3 neovascularization and is associated with poor visual outcome. Additional studies are needed to determine how abrupt visual loss can be prevented. 展开更多
关键词 age-related macular degeneration TYPE 3 NEOVASCULARIZATION RETINAL angiomatous proliferation hemorrhage tear in RETINAL PIGMENT epithelium PIGMENT epithelial DETACHMENT
Advances in the treatment of rhegmatogenous retinal detachment
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作者 Li Liao Xiao-Hua Zhu 《国际眼科杂志:英文版》 SCIE CAS 2019年第4期660-667,共8页
The pathogenesis of rhegmatogenous retinal detachment depends on three factors, namely, retinal rupture, vitreous liquefaction and traction causing the retina to separate from the pigment epithelium, among which retin... The pathogenesis of rhegmatogenous retinal detachment depends on three factors, namely, retinal rupture, vitreous liquefaction and traction causing the retina to separate from the pigment epithelium, among which retinal rupture is the most important. Retinopathy is caused by a gap between the neurosensory retina and the retinal pigment epithelium, which severely damages the visual function of the patient. Therefore, early clinical discovery, prevention and selection of an appropriate treatment are important. This article reviews progress in the treatment of retinal detachment. 展开更多
关键词 rhegmatogenous RETINAL detachment TREATMENT progress SCLERA external-route surgery RETINAL laser PHOTOCOAGULATION PARS plana VITRECTOMY
玻璃体后脱离相关视网膜裂孔的临床观察
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作者 吕刚 孟洁 黄红深 《中华眼外伤职业眼病杂志》 2019年第2期151-152,共2页
目的观察玻璃体后脱离相关视网膜裂孔的临床特点。方法回顾性分析2017年6月至2018年6月玻璃体后脱离相关视网膜裂孔32例(32眼)的临床资料,进行视网膜光凝封闭裂孔。结果32眼光凝均顺利完成。术后3周复诊时光凝斑形成良好。结论玻璃体后... 目的观察玻璃体后脱离相关视网膜裂孔的临床特点。方法回顾性分析2017年6月至2018年6月玻璃体后脱离相关视网膜裂孔32例(32眼)的临床资料,进行视网膜光凝封闭裂孔。结果32眼光凝均顺利完成。术后3周复诊时光凝斑形成良好。结论玻璃体后脱离必须散瞳检查视网膜,视网膜光凝是玻璃体后脱离相关视网膜裂孔有效治疗方法。 展开更多
关键词 脱离 后玻璃体 裂孔 视网膜 光凝 视网膜
Role of microglial cells in photoreceptor degeneration 预览
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作者 Johnny Di Pierdomenico Diego García-Ayuso +2 位作者 Marta Agudo-Barriuso Manuel Vidal-Sanz María Paz Villegas-Pérez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第7期1186-1190,共5页
Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigment... Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations. 展开更多
关键词 Royal College of SURGEONS RCS P23H-1 MICROGLIA MINOCYCLINE PHOTORECEPTOR retinal DEGENERATION RETINITIS pigmentosa
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Activation of autophagy in the retina after optic nerve crush injury in rats
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作者 Li-Hua Kang Su Zhang +1 位作者 Sheng Jiang Nan Hu 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1395-1401,共7页
AIM: To investigate the activation of autophagy in rat retina after optic nerve crush(ONC) and evaluate its relationship with apoptosis of retinal ganglion cells(RGCs).METHODS: The ONC model was established. Western b... AIM: To investigate the activation of autophagy in rat retina after optic nerve crush(ONC) and evaluate its relationship with apoptosis of retinal ganglion cells(RGCs).METHODS: The ONC model was established. Western blots were performed to investigate expression of p62, LC3 and Beclin-1. Transmission electron microscopy was performed to discover the autophagosomes in the retina after ONC. Immunohistochemistry was used to confirm the distribution of LC3. TUNEL was performed to confirm the relationship between autophagy and RGC apoptosis. RESULTS: p62/Beclin-1 ratio was declined shortly after ONC until to day 7 after ONC and then restored to a normal level at day 21. There was an opposite change in the LC3-II/LC3 I ratio in the retina compared to the p62/Beclin-1 ratio. Increased autophagosomes were found after ONC using transmission electron microscopy, and most of the LC3-stained cells were colocalized with RGCs and Müller cells. More LC3-immunoreactive cells and apoptotic RGCs were found on day 7 following ONC. CONCLUSION: Possible activation of autophagy in RGCs after ONC;autophagy mainly occurred in RGCs and Müller cells, and the apoptosis of RGCs after ONC may be partly associated with autophagic activation. 展开更多
关键词 AUTOPHAGY OPTIC nerve CRUSH apoptosis retinal GANGLION cells rat
Does the scleral encircling band provide a protective effect against the progression of diabetic retinopathy?
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作者 Hossam Youssef Abouelkheir Amani E Badawi +5 位作者 Amr M.Abdelkader Amr El-Kanishy Sameh Saleh Waleed Ali Abou Samra Manal Ali Kasem Tharwat Mokbel 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1408-1414,共7页
AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic patients.METHODS: The medical records of diabetic patients who underwent unilateral re... AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic patients.METHODS: The medical records of diabetic patients who underwent unilateral retinal detachment(RD) surgery using scleral buckle and encircling band were reviewed retrospectively. Both eyes of patients were included in the study: one eye in each patient had a scleral buckle with encircling band(the operated eye) and the other one is the non-operated eye. The demographic characters, duration of diabetes and period between surgery and the last recall visit were retrieved from each patient. All the cases underwent fundus photo and fluorescein angiography(when indicated) to confirm the DR staging.RESULTS: Totally 25 patients fulfilled the inclusion and the exclusion criteria were become eligible for the study. A total of 50 eyes of 25 patients were enrolled in this analysis. The mean period of time passed from surgery with encircling band and the last reassessment visit was 12.5±2 y. Even though DR could develop in the operated eyes, it was at a less degree of severity compared to the non-operated eyes of same patients(P=0.027).CONCLUSION: Scleral encircling bands have protective effects against the development and progression of DR. 展开更多
关键词 DIABETIC RETINOPATHY scleral ENCIRCLING BANDS RETINAL DETACHMENT
Down regulation of UCP2 expression in retinal pigment epithelium cells under oxidative stress: an in vitro study
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作者 Ying Liu Yuan Ren +3 位作者 Xia Wang Xu Liu Yun Xu Yuan He 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1089-1094,共6页
AIM: To evaluate the expression of uncoupling protein 2(UCP2) in a retinal pigment epithelium cell line(ARPE-19), under oxidative stress(OS).METHODS: ARPE-19 cells were divided into groups treated with various concent... AIM: To evaluate the expression of uncoupling protein 2(UCP2) in a retinal pigment epithelium cell line(ARPE-19), under oxidative stress(OS).METHODS: ARPE-19 cells were divided into groups treated with various concentrations of hydrogen peroxide(H2 O2;0, 150, 300, 500, 700, and 900 μmol/L) for 24 h, to induce oxidative damage and cell viability was assessed by MTT assay. UCP2 mRNA expression in cells treated with H2 O2 was investigated by reverse transcription-polymerase chain reaction(RT-PCR). UCP2 protein expression was assessed by Western blotting and ROS levels analyzed by flow cytometry(FCM). Further, UCP2-siRNA treated cultures were exposed to H2 O2(0, 75, 150, and 300 μmol/L) for 2 h and cell viability determined by MTT assay.RESULTS: Cells treated with higher concentrations of H2 O2 appeared shrunken;their adhesion to adjacent cells was disrupted, and the number of dead cells increased. The results of cell viability assays demonstrated that the numbers of cells were decreased in a dose-dependent manner following treatment with H2 O2. Compared with untreated controls, cell viability was significantly reduced after treatment with >300 μmol/L H2 O2(P<0.05). Cell metabolic activity was decreased with increased concentrations of H2 O2 as detected by MTT assay. Levels of OS were further decreased in cells treated with UCP2-siRNA compared with those treated with H2 O2 alone(P<0.05). The results of RT-PCR and Western blotting demonstrated that UCP2 expression was reduced in H2 O2-treated groups compared with controls(P<0.05). FCM analysis showed that cell reactive oxygen species(ROS) levels were increased in H2 O2-treated groups and further upregulated by UCP2-si RNA treatment(P<0.05).CONCLUSION: Expression levels of UCP2 are decreased in ARPE-19 cells treated with H2 O2. ROS levels are further increased in cells treated with UCP2-siRNA relative to those treated with H2 O2 alone. UCP2 may have a protective role in ARPE-19 cells during oxidative injury. 展开更多
关键词 UNCOUPLING protein 2 RETINAL PIGMENT EPITHELIUM CELLS oxidative stress
Is there a relationship between dopamine and rhegmatogenous retinal detachment? 预览
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作者 Alessio Martucci Massimo Cesareo +5 位作者 Maria Dolores Pinazo-Durán Michela Di Pierro Matteo Di Marino Carlo Nucci Massimiliano Coletta Raffaele Mancino 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期311-314,共4页
Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing th... Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Ver gata University Hospital(R.S.92.10) on September 24, 2010. 展开更多
关键词 3 4-dihydroxyphenylacetic acid DOPAC DOPAMINE DOPAMINERGIC amacrine cells DOPAMINERGIC NEUROTOXICITY MACULAR pucker oxidative stress PHOTORECEPTOR degeneration rhegmatogenous retinal DETACHMENT vitreous hemorrhage
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Macular retinal thickness and flow density change by optical coherence tomography angiography after posterior scleral reinforcement
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作者 Liya Qiao Xifang Zhang +3 位作者 Catherine Jan Xiaoxia Li Meng Li Huaizhou Wang 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第7期930-936,共7页
Optical coherence tomography angiography(Angio-OCT) has introduced a new non-invasive,quantitative method to assess superficial and deep capillary networks of the retina.In this study,we investigated macular retinal t... Optical coherence tomography angiography(Angio-OCT) has introduced a new non-invasive,quantitative method to assess superficial and deep capillary networks of the retina.In this study,we investigated macular retinal thickness and flow density change following posterior scleral reinforcement(PSR) surgery,using an RTVue XR Avanti Angio-OCT,in patients with pathological myopia.A total of 13 patients with pathological myopia were recruited and all patients completed the 6 months follow-up visit.Data from 22 eyes were used in this study.The mean age was 36.23±15.29 years,and 43%(n=6) were men.Spherical equivalent refractive error(SE) ranged from –8.0 to –24.0 D.Postoperative axial length,best-corrected visual acuity and SE did not change significantly at each follow-up,compared with pre-operative measures(P>0.05).Postoperative flow density of superficial and deep retinal layers at each sector did not change significantly at each follow-up,compared with preoperative measures(P>0.05).However,we found significant decrease in retinal thickness of parafovea-inferior sector after PSR surgery(P<0.01),indicating potential relaxation of vitreofoveal traction after PSR surgery. 展开更多
关键词 MACULAR RETINAL thickness MACULAR flow density optical COHERENCE tomography ANGIOGRAPHY POSTERIOR scleral REINFORCEMENT
Etomidate affects the anti-oxidant pathway to protect retinal ganglion cells after optic nerve transection 预览
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作者 Xuan Zhao Fang Kuang +2 位作者 Yi-Yan You Ming-Mei Wu Si-Wei You 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期2020-2024,共5页
Our previous studies revealed that etomidate, a non-barbiturate intravenous anesthetic agent, has protective effects on retinal ganglion cells within 7 days after optic nerve transection. Whether this process is relat... Our previous studies revealed that etomidate, a non-barbiturate intravenous anesthetic agent, has protective effects on retinal ganglion cells within 7 days after optic nerve transection. Whether this process is related to anti-oxidative stress is not clear. To reveal its mechanism, we established the optic nerve transection injury model by transecting 1 mm behind the left eyeball of adult male Sprague-Dawley rats. The rats received an intraperitoneal injection of etomidate(4 mg/kg) once per day for 7 days. The results showed that etomidate significantly enhanced the number of retinal ganglion cells retrogradely labeled with Fluorogold at 7 days after optic nerve transection. Etomidate also significantly reduced the levels of nitric oxide and malonaldehyde in the retina and increased the level of glutathione at 12 hours after optic nerve transection. Thus, etomidate can protect retinal ganglion cells after optic nerve transection in adult rats by activating an anti-oxidative stress response. The study was approved by the Animal Ethics Committee at Air Force Medical University, China(approval No. 20180305) on March 5, 2018. 展开更多
关键词 NERVE REGENERATION ETOMIDATE retinal ganglion cells optic NERVE TRANSECTION anti-oxidative stress nitric oxide MALONALDEHYDE glutathione neural REGENERATION
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Widefield optical coherence tomography of foveal dragging in retinopathy of prematurity
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作者 Victor M.Villegas Stephen G.Schwartz +2 位作者 Audina M.Berrocal Timothy G.Murray Harry W. Flynn Jr. 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1219-1223,共5页
Dear Editor,Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with struct... Dear Editor,Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with structural retinal abnormalities (including retinal detachment, retinal folds, and pigmentary retinopathy), cataract, glaucoma, and amblyopia due to refractive error or strabismus[2]. 展开更多
关键词 RETINOPATHY of prematurity(ROP) foveal DRAGGING structural RETINAL ABNORMALITIES
硅油填充眼发生视网膜脱离的原因及治疗效果
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作者 张威 王文战 《中华眼外伤职业眼病杂志》 2019年第3期165-168,共4页
目的分析硅油填充眼发生视网膜脱离的原因及治疗效果。方法回顾性分析2017年1月至2018年6月本院玻璃体切除术后硅油填充眼发生视网膜脱离70例(70只眼)的临床资料结果硅油眼发生视网膜脱离的原因有3类:视网膜下积液的产生者10只眼(14. 29... 目的分析硅油填充眼发生视网膜脱离的原因及治疗效果。方法回顾性分析2017年1月至2018年6月本院玻璃体切除术后硅油填充眼发生视网膜脱离70例(70只眼)的临床资料结果硅油眼发生视网膜脱离的原因有3类:视网膜下积液的产生者10只眼(14. 29%);原发裂孔闭合不佳或新裂孔形成者13只眼(18.57%);增生性玻璃体视网膜病变(PVR)进展者47只眼(67. 14%).所有患者经再次行视网膜修复术后视网膜均复位,再次术后的视力(BCVA)提高者60只眼(85.71%),不变化者9只眼(12.86%),下降者1只眼(1.43%)。术后平均视力(logMAR)优于术前,差异有统计学意义(t= 8.316,P = 0.000)(结论硅油眼发生视网膜脱离的主要原因是PVR进展,其次是原发裂孔闭合不佳或新裂孔形成,以及视网膜下积液产生。再次行视网膜复位手术可取得较好的治疗效果。 展开更多
关键词 视网膜脱离 原因 效果 治疗
抗VEGF联合激光治疗视网膜静脉阻塞合并黄斑水肿 预览
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作者 欧玉仑 周小平 +4 位作者 谢丽莲 田涛 刘茹 彭婧丽 邝国平 《国际眼科杂志》 CAS 北大核心 2019年第7期1162-1165,共4页
目的:观察抗VEGF联合激光治疗视网膜静脉阻塞合并黄斑水肿的临床疗效。方法:选取2017-03/09在我院眼科确诊的视网膜静脉阻塞合并黄斑水肿患者62例62眼,随机进行分组,A组行单纯视网膜激光治疗,B组和C组先分别行玻璃体腔注射康柏西普和雷... 目的:观察抗VEGF联合激光治疗视网膜静脉阻塞合并黄斑水肿的临床疗效。方法:选取2017-03/09在我院眼科确诊的视网膜静脉阻塞合并黄斑水肿患者62例62眼,随机进行分组,A组行单纯视网膜激光治疗,B组和C组先分别行玻璃体腔注射康柏西普和雷珠单抗,再进行视网膜激光治疗。随访6mo,观察三组患者的临床疗效。结果:治疗后三组患者黄斑中心视网膜厚度(CMT)均较治疗前显著降低,且B组和C组患者CMT均低于A组( P < 0.05),但两组之间无差异( P >0.05)。治疗后6mo,三组患者治疗总有效率分别为44%、86%、86%( P <0.05),B组和C组患者治疗总有效率均高于A组( P <0.0167)。结论:玻璃体腔注射康柏西普或雷珠单抗联合视网膜激光治疗视网膜静脉阻塞合并黄斑水肿可有效减轻黄斑水肿,改善视力,疗效相似。 展开更多
关键词 雷珠单抗 康柏西普 视网膜激光治疗 视网膜静脉阻塞
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Novel transscleral sutureless subretinal fluid drainage using a 25-gauge trocar-cannula with a self-closing valve in patients with advanced Coats disease
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作者 Liang Li Song-Feng Li +4 位作者 Jing-Hua Liu Guang-Da Deng Yan Ma Jing Ma Hai Lu 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1444-1449,共6页
AIM: To assess surgical outcomes of a novel method of transscleral drainage of subretinal fluid using a 25-gauge trocar-cannula with a self-closing valve(DTV) in patients with severe exudative retinal detachment(ERD) ... AIM: To assess surgical outcomes of a novel method of transscleral drainage of subretinal fluid using a 25-gauge trocar-cannula with a self-closing valve(DTV) in patients with severe exudative retinal detachment(ERD) in Coats disease.METHODS: Retrospective consecutive cases of 20 patients(20 eyes) of severe ERD due to Coats disease(stage 3 B) in total 156 Coats patients between June 2015 and April 2019 were included in this study. The participants were aged 1 to 10 y with a mean age of 3.50±1.79 y. The mean follow-up time were 11.9 mo. Subretinal fluid was drained transsclerally using a novel method of DTV. The height of the retinal detachment and the regression of abnormal vessels including telangiectasias and aneurysms were observed. Complications including vitreoretinal fibrosis, tractional retinal detachments(TRD), endophthalmitis, retinal holes, and hemorrhages were evaluated.RESULTS: Following surgeries, the patients showed the replacement of ERD and regression of telangiectatic retinal vessels observed with binocular indirect ophthalmoscopy. Six patients received retinal cryotherapies and 12 patients received laser photocoagulations following first external subretinal fluid drainage using DTV. All patients underwent intravitreal anti-vascular endothelial growth factor therapies to induce residual subretinal fluid absorption. During followups, 8 patients underwent a second drainage operation, 17 patients received retinal laser photocoagulations and 7 patients received cryotherapies. Vitreoretinal fibrosis was found in 7 patients and 6 patients underwent microinvasive vitrectomies during the follow-up period. Severe TRD, iatrogenic retinal holes, and hemorrhages were not found.CONCLUSION: The authors present a new therapeutic approach that successfully drains subretinal fluid in advanced stage 3 B Coats disease with severe ERD. This is a simple, safe and less invasive approach when compared with traditional managements. However, it should be strictly selected for patients with high bullous ERD close to the 展开更多
关键词 Coats disease subretinal fluid EXUDATIVE retinal DETACHMENT transscleral drainage
前房灌注联合玻璃体手术治疗伴有脉络膜脱离的视网膜脱离
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作者 曲申 林梦真 +5 位作者 牛耘丽 韩雯婷 徐海玥 张娟 毕燕龙 荣翱 《中华眼外伤职业眼病杂志》 2019年第8期567-571,共5页
目的评价前房灌注联合玻璃体切除术治疗伴有脉络膜脱离的视网膜脱离的效果。方法回顾性分析2017年1月至2018年2月在同济大学附属同济医院眼科就诊的伴有脉络膜脱离的视网膜脱离者16例(16只眼)的临床资料。所有患者在前房灌注的辅助下行... 目的评价前房灌注联合玻璃体切除术治疗伴有脉络膜脱离的视网膜脱离的效果。方法回顾性分析2017年1月至2018年2月在同济大学附属同济医院眼科就诊的伴有脉络膜脱离的视网膜脱离者16例(16只眼)的临床资料。所有患者在前房灌注的辅助下行玻璃体切除联合硅油填充术,术后随访6个月以上。结果术后1天至3个月所有患者视网膜均复位,复位率达100%。术后6个月,在硅油取出术中发现视网膜再次脱离1例,进行硅油置换。术后1、3及6个月,视力(LogMAR)依次为1.75±0.45、1.50±0.53、1.33±0.66,与手术前比较,差异有统计学意义(F=59.58,P=0.001)。术后1、3及6个月,眼压依次为(12.67±6.91)mmHg、(14.35±6.75)mmHg、(15.12±6.16)mmHg(1mmHg=0.133 kPa)。与术前比较,差异均有统计学意义(F=2.26,P=0.01)。结论玻璃体切除术联合前房灌注可有效治疗伴有脉络膜脱离的视网膜脱离。脉络膜及视网膜复位情况较好,视力有一定改善。 展开更多
关键词 脱离 视网膜 脱离 脉络膜 玻璃体切除术 灌注 前房
Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina
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作者 Takahiro Kurose Eriko Sugano +7 位作者 Akihisa Sugai Raki Shiraiwa Mariyo Kato Yoko Mitsuguchi Yoshihiro Takai Kitako Tabata Yoichi Honma Hiroshi Tomita 《国际眼科杂志:英文版》 SCIE CAS 2019年第8期1231-1237,共7页
AIM: To evaluate the neuroprotective effect of a dietary supplement(ClearVision EX~?;CV) against glutamateinduced excitotoxicity in retina.METHODS: We evaluated the protective effects CV on glutamate-induced cell toxi... AIM: To evaluate the neuroprotective effect of a dietary supplement(ClearVision EX~?;CV) against glutamateinduced excitotoxicity in retina.METHODS: We evaluated the protective effects CV on glutamate-induced cell toxicity of an immortalized mouse hippocampal cell line(HT-22) in vitro and N-methyl-Daspartate(NMDA) induced retinal injury in vivo. Once-daily oral administration of CV or vehicle(5% Arabic gum) was started the day before the NMDA injection and continued until the end of the study. Electroretinograms(ERGs) were recorded to evaluate the retinal function at 2 d after NMDA injection. Furthermore, a histological evaluation, Western blot analysis, and immunohistochemistry were performed for assessing the signal transduction pathway. RESULTS: HT-22 cell death was induced by the addition of glutamate and co-incubation with CV protected against it. Oral administration of CV inhibited the decrease in scotopic threshold response amplitudes induced by the intravitreal injection of NMDA and those of the thickness of the inner retinal layer in the histological evaluation. The increased phosphorylated levels of extracellular signalregulated kinase(ERK) but not cAMP response element binding protein(CREB) or Akt were observed 1 h after NMDA injection in both the vehicle-and CV-treated rats;however, p ERK activation was no more upregulated at 3 h after NMDA injection. pERK upregulation was observed in Müller cells.CONCLUSION: CV shows a protective effect against both glutamate-induced HT-22 cell death and NMDAinduced retinal damage. pERK upregulation in the Müller cells plays a key role in the protective effect of CV against glutamate-induced retinal toxicity. 展开更多
关键词 glutamate-induced toxicity retinal GANGLION CELLS HT-22 CELLS PERK
康柏西普联合光凝治疗视网膜分支静脉阻塞黄斑水肿
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作者 赵学军 张小鹏 张超玲 《中华眼外伤职业眼病杂志》 2019年第2期143-146,共4页
目的观察玻璃体内注射康柏西普联合光凝治疗缺血型视网膜分支静脉阻塞所致黄斑水肿的临床疗效。方法回顾性分析2014年6月至2018年4月在本院眼科缺血型视网膜分支静脉阻塞所致黄斑水肿48例(48眼)的临床资料,患者按住院顺序平均分为观察... 目的观察玻璃体内注射康柏西普联合光凝治疗缺血型视网膜分支静脉阻塞所致黄斑水肿的临床疗效。方法回顾性分析2014年6月至2018年4月在本院眼科缺血型视网膜分支静脉阻塞所致黄斑水肿48例(48眼)的临床资料,患者按住院顺序平均分为观察组和对照组,观察组行康柏西普联合视网膜激光光凝治疗,对照组直接行视网膜激光光凝治疗。观察两组治疗前及治疗后1周、1个月、3个月的最佳矫正视力、黄斑中心区视网膜厚度及并发症情况。结果观察组和对照组的视力和黄斑中心区视网膜厚度的差异在治疗后各时间点均有统计学意义(P<0.05)。结论玻璃体内注射康柏西普联合激光治疗缺血型视网膜分支静脉阻塞所致黄斑水肿可提高视力,减轻水肿,预防并发症的发生。 展开更多
关键词 阻塞 分支静脉 视网膜 水肿 黄斑 康柏西普 玻璃体内注射 光凝 激光
Rac1 Modulates Excitatory Synaptic Transmission in Mouse Retinal Ganglion Cells
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作者 Ling-Zhu Li Ning Yin +8 位作者 Xue-Yan Li Yanying Miao Shuo Cheng Fang Li Guo-Li Zhao Shu-Min Zhong Xin Wang Xiong-Li Yang Zhongfeng Wang 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第4期673-687,共15页
Ras-related C3 botulinum toxin substrate 1(Racl),a member of the Rho GTPase family which plays important roles in dendritic spine morphology and plasticity,is a key regulator of cytoskeletal reorganization in dendrite... Ras-related C3 botulinum toxin substrate 1(Racl),a member of the Rho GTPase family which plays important roles in dendritic spine morphology and plasticity,is a key regulator of cytoskeletal reorganization in dendrites and spines.Here,we investigated whether and how Racl modulates synaptic transmission in mouse retinal ganglion cells(RGCs)using selective conditional knockout of Racl(Racl-cKO).Racl-cKO significantly reduced the frequency of AMPA receptor-mediated miniature excitatory postsynaptic currents,while glycine/GABA_A receptor-mediated miniature inhibitory postsynaptic currents were not affected.Although the total GluA1 protein level was increased in Racl-cKO mice,its expression in the membrane component was unchanged.RaclcKO did not affect spine-like branch density in single dendrites,but significantly reduced the dendritic complexity,which resulted in a decrease in the total number of dendritic spine-like branches.These results suggest that Racl selectively affects excitatory synaptic transmission in RGCs by modulating dendritic complexity. 展开更多
关键词 RAC1 Retinal GANGLION cell EXCITATORY SYNAPTIC transmission DENDRITE Dendritic SPINE
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