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Role of microglial cells in photoreceptor degeneration 预览
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作者 Johnny Di Pierdomenico Diego García-Ayuso +2 位作者 Marta Agudo-Barriuso Manuel Vidal-Sanz María Paz Villegas-Pérez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第7期1186-1190,共5页
Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigment... Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations. 展开更多
关键词 Royal College of SURGEONS RCS P23H-1 MICROGLIA MINOCYCLINE PHOTORECEPTOR retinal DEGENERATION RETINITIS pigmentosa
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巨细胞病毒性视网膜炎诊断和治疗的研究进展
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作者 张雪 欧阳净 陈耀凯 《中华实验和临床病毒学杂志》 CAS CSCD 2019年第4期444-448,共5页
巨细胞病毒性视网膜炎(cytomegalovirus retinitis,CMVR)是艾滋病患者最常见的眼部机会性感染,在缺乏准确诊断和有效治疗的情况下,会给患者造成不同程度的眼部损伤甚至失明,故CMVR的早期诊断和及时治疗尤为重要。为此本文将从CMVR的临... 巨细胞病毒性视网膜炎(cytomegalovirus retinitis,CMVR)是艾滋病患者最常见的眼部机会性感染,在缺乏准确诊断和有效治疗的情况下,会给患者造成不同程度的眼部损伤甚至失明,故CMVR的早期诊断和及时治疗尤为重要。为此本文将从CMVR的临床表现、诊断方法以及治疗药物等方面进行综述。 展开更多
关键词 巨细胞病毒 视网膜炎 艾滋病 诊断 治疗
Effect of individualized therapy for AIDS patients with cytomegalovirus retinitis in intravitreal ganciclovir injections
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作者 Lian-Yong Xie Chao Chen +4 位作者 Wen-Jun Kong Kui-Fang Du Chun-Gang Guo Hong-Wei Dong Wen-Bin Wei 《国际眼科杂志:英文版》 SCIE CAS 2019年第8期1351-1355,共5页
The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome(AIDS) patients with cytomegalovirus retinitis(CMVR) was investigated. A total of 32 eyes in 23... The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome(AIDS) patients with cytomegalovirus retinitis(CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anticytomegalovirus(CMV) agent ganciclovir(5 mg/kg q12 h) combined with intravitreal ganciclovir injection(3 mg/time, 2 times/wk). The visual acuity, fundus photographs, lesion location, and number of intravitreal injections were observed preoperatively and postoperatively. Totally 14 eyes were cured during induction therapy. The number of injections [4.13(2 to 6)] in CMVR patients with peripherally fundus lesions were significantly lower than those with central lesions (4.89(2 to 6))The individualized therapy of intravitreal ganciclovir injections for AIDS patients with CMVR can effectively reduce the numbers of intravitreal injections. 展开更多
关键词 CYTOMEGALOVIRUS RETINITIS acquired immune deficiency syndrome GANCICLOVIR INTRAVITREAL injection MONOTHERAPY
Fundus manifestations and HIV viral loads of AIDS patients before and after HAART
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作者 Yu Di Xin-Yu Zhao +2 位作者 Jun-Jie Ye Bing Li Nan Ma 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1438-1443,共6页
AIM: To investigate the fundus manifestations and human immunodeficiency virus(HIV) viral loads of acquired immune deficiency syndrome(AIDS) patients before and after highly active antiretroviral therapy(HAART).METHOD... AIM: To investigate the fundus manifestations and human immunodeficiency virus(HIV) viral loads of acquired immune deficiency syndrome(AIDS) patients before and after highly active antiretroviral therapy(HAART).METHODS: This retrospective study included 21 AIDS patients(42 eyes) who presented to the Department of Ophthalmology, Peking Union Medical College Hospital, from 2007 to 2011. Among the patients, 16 showed a good response to HAART, 3 presented drug resistance and 2 were pre-HAART. All patients underwent comprehensive ophthalmic examinations. The HIV viral loads and the CD4+ T-cell counts were also determined.RESULTS: The best-corrected visual acuity(BCVA) of 38 eyes(19 patients) was improved, and cytomegalovirus retinitis(CMVR) in 5 eyes(3 patients) regressed after HAART. Furthermore, 16 patients treated with effective HAART had decreased plasma HIV viral loads(<78 copies/mL)and increased CD4+ T-cell counts(343±161 cells/μL, P<0.005), but the HIV viral load in tears was still detected at 2404 copies/mL. The CD4+ T-cell count was lower in the CMVR group than in the non-CMVR group(P=0.022), but the HIV viral load in the tears was not significantly different between the two groups(P=0.439).CONCLUSION: Most patients with AIDS show a good viral response with a decreased HIV viral load and an increased CD4+ T-cell count in plasma after HAART. However, the HIV viral load remain quite high in the tear samples. Based on our results, we suggest that AIDS patients undergo long-term HAART that should not be interrupted. 展开更多
关键词 acquired immune deficiency syndrome CYTOMEGALOVIRUS RETINITIS highly active ANTIRETROVIRAL therapy human immunodeficiency virus viral loads TEARS
非洲布隆迪地区艾滋病并发巨细胞病毒性视网膜炎85例临床分析
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作者 张道远 达克斯 《青海医药杂志》 2019年第4期1-4,共4页
目的:分析艾滋病并发巨细胞病毒性视网膜炎的临床特征及危险因素,并总结疾病管理对策。方法:选取2016年2月-2018年2月,笔者在非洲布隆迪布琼布拉省中心医院援非医疗队工作期间收治的艾滋病(AIDS)并发巨细胞病毒性视网膜炎患者85例,纳入... 目的:分析艾滋病并发巨细胞病毒性视网膜炎的临床特征及危险因素,并总结疾病管理对策。方法:选取2016年2月-2018年2月,笔者在非洲布隆迪布琼布拉省中心医院援非医疗队工作期间收治的艾滋病(AIDS)并发巨细胞病毒性视网膜炎患者85例,纳入病例组。未发生巨细胞病毒性视网膜炎107例,纳入对照组。收集资料、开展描述性分析,并结合患者临床资料进行Logistic因素分析。结果:病例组无光感失明者11.8%,棉绒斑54.1%,CMVR 23.5%,渗出以及散在的出血22.4%,视网膜脱离17.6%,眼压上升25.9%。视力得到不同程度的改善占24.7%,视力下降占37.6%,有2例新发失明。平均随访时间(11.4±5.6)个月,复发率12.9%(11/85)。病例组WBC、年龄、病程高于对照组,CD4低于对照组,差异有统计学意义(P<0.05)。病例组抗病毒药物使用率、原发眼病率低于对照组,病例组逆转录治疗停药率高于对照组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示CD4与原发眼病成为独立影响因素(P<0.05)。结论:艾滋病并发巨细胞病毒性视网膜炎表现多样化,视力受损严重,且会进展变化;因此需要重视艾滋病规范治疗,重视改善免疫功能,积极治疗原发眼病。 展开更多
关键词 非洲 布隆迪 艾滋病 巨细胞病毒感染 视网膜炎
Whole-exome sequencing identifies novel mutations in genes responsible for retinitis pigmentosa in 2 nonconsanguineous Chinese families
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作者 Yan-Shan Hu Hui Song +2 位作者 Yin Li Zi-Yun Xiao Tuo Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第6期915-923,共9页
AIM: To detect the pathogenetic mutations responsible for nonsyndromic autosomal recessive retinitis pigmentosa(RP) in 2 nonconsanguineous Chinese families. METHODS: The clinical data, including detailed medical histo... AIM: To detect the pathogenetic mutations responsible for nonsyndromic autosomal recessive retinitis pigmentosa(RP) in 2 nonconsanguineous Chinese families. METHODS: The clinical data, including detailed medical history, best corrected visual acuity(BCVA), slit-lamp biomicroscope examination, fundus photography, optical coherence tomography, static perimetry, and full field electroretinogram, were collected from the members of 2 nonconsanguineous Chinese families preliminarily diagnosed with RP. Genomic DNA was extracted from the probands and other available family members;wholeexome sequencing was conducted with the DNA samples provided by the probands, and all mutations detected by whole-exome sequencing were verified using Sanger sequencing in the probands and the other available family members. The verified novel mutations were further sequenced in 192 ethnicity matched healthy controls.RESULTS: The patients from the 2 families exhibited the typical symptoms of RP, including night blindness and progressive constriction of the visual field, and the fundus examinations showed attenuated retinal arterioles, peripheral bone spicule pigment deposits, and waxy optic discs. Whole-exome sequencing revealed a novel nonsense mutation in FAM161 A(c.943 A>T, p.Lys315*) and compound heterozygous mutations in RP1 L1(c.56 C>A, p.Pro19 His;c.5470 C>T, p.Gln1824*). The nonsense c.5470 C>T, p.Gln1824* mutation was novel. All mutations were verified by Sanger sequencing. The mutation p.Lys315* in FAM161A co-segregated with the phenotype, and all the nonsense mutations were absent from the ethnicity matched healthy controls and all available databases.CONCLUSION: We identify 2 novel mutations in genes responsible for autosomal recessive RP, and the mutation in FAM161A is reported for the first time in a Chinese population. Our result not only enriches the knowledge of the mutation frequency and spectrum in the genes responsible for nonsyndromic RP but also provides a new target for future gene therapy. 展开更多
关键词 RETINITIS pigmentosa NONSYNDROMIC whole-exome SEQUENCING MUTATION novel
Valproic acid’s effects on visual acuity in retinitis pigmentosa: a systemic review and Meta-analysis
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作者 Wen-Jun Chen Li Ma +1 位作者 Ming-Shu Li Xiang Ma 《国际眼科杂志:英文版》 SCIE CAS 2019年第1期129-134,共6页
AIM: To gain a better understanding of the overall efficacy of valproic acid(VPA) treatment for retinitis pigmentosa(RP). METHODS: Publications in PubMed, EMBASE, Cochrane Library, Web of Science and Clinicaltrials.go... AIM: To gain a better understanding of the overall efficacy of valproic acid(VPA) treatment for retinitis pigmentosa(RP). METHODS: Publications in PubMed, EMBASE, Cochrane Library, Web of Science and Clinicaltrials.gov were searched for clinical trials of patients with RP assigned to treatment with VPA. Patients’ pre-and post-treatment visual field(VF) and best-corrected visual acuity(BCVA) scores were extracted and compared to assess changes. RESULTS: A total of 78 reports were retrieved and 6 studies involving 116 patients were included in the Meta-analysis.The combined results showed a significant decrease in logarithm of minimal angle of resolution(logMAR) scores,calculated using baseline and post-treatment BCVA(P<0.00001, mean difference=-0.05, 95%CI:-0.05,-0.04,I2=36%) scores, which means there was considerable improvement in visual acuity. Meanwhile, more BCVA changes were observed in short-term(≤6 mo) treatment studies(P<0.00001, mean difference=-0.05, 95%CI:-0.05,-0.04, I2=38%), studies conducted in Asia(P<0.00001,mean difference=-0.05, 95%CI:-0.05,-0.04, I2=4%), studies with a sample size of 30 or fewer patients(P<0.00001,mean difference=-0.05, 95%CI:-0.05,-0.04, I2=38%) and prospective studies(P<0.00001, mean difference=-0.05,95%CI:-0.05,-0.04, I2=0%). However, VPA’s effect on VF was inconsistent across studies(P=0.75, mean difference=-22.76, 95%CI:-160.56, 115.05, I2=68%). CONCLUSION: This Meta-analysis reveals that most RP patients who were treated with VPA showed improvement in BCVA. However, its effect on VF remains inconsistent.VPA may be a promising treatment for RP. 展开更多
关键词 RETINITIS pigmentosa valproic ACID VISUAL ACUITY META-ANALYSIS
CD4+ cells as a potential biomarker for cytomegalovirus retinitis in children with acute lymphocytic leukemia
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作者 Jian-Cang Wang Fei-Fan Du +3 位作者 Ming Su Xiao-Ge Yang Mei-Jie Quan Xiao-Ying Zhai 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第3期356-359,共4页
To the Editor: Infection is one of the causes of death after chemotherapy in children with leukemia. About 20% to 30% acute lymphocytic leukemia (ALL) patients die from infection after chemotherapy.[1] Patients with i... To the Editor: Infection is one of the causes of death after chemotherapy in children with leukemia. About 20% to 30% acute lymphocytic leukemia (ALL) patients die from infection after chemotherapy.[1] Patients with immune deficiency, under chemotherapy, or treated with immunosuppressor are more inclined to be infected with human cytomegalovirus (HCMV) which leads to severe systematic disorders.[2] Cytomegalvirus retinitis (CMVR) is a major sight threatening disease which mainly occurs in patients with immune deficiency and results in blindness if treatment is delayed. The decrease of CD4+ T cells has been related to CMVR in immune deficiency syndrome like AIDS.[3] However, little is known about the relation between the level of T cells with different markers and the onset of CMVR in ALL patients under chemotherapy. Therefore, this study was designed to investigate the diagnostic value of T cells with different markers for cytomegalovirus retinitis after chemotherapy in patients with ALL. 展开更多
关键词 CYTOMEGALOVIRUS RETINITIS acute LYMPHOCYTIC LEUKEMIA CD4+ cells
Visual field mean deviation and relevant factors in 928 Chinese retinitis pigmentosa patients
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作者 Hui Ye Xiao-Ping Xia 《国际眼科杂志:英文版》 SCIE CAS 2018年第12期1978-1983,共6页
AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual... AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual acuity and retinal pigmentation were analyzed in 928 RP patients. MD decreasing rate in 10 y and potential influences of gender, age, family history and retinal pigmentation on the rate were explored in 201 RP patients. RESULTS: In the 928 patients, average MD and visual acuity were-14.44±8.61 dB and 0.79±0.35 respectively and when MD was lower than-9.18 dB the visual acuity would be below 1.0(20/20). The average MD medium between eyes with or without retinal pigmentation was-14.82 dB. In 123 non-pigmented eyes, the average MD were lower than the medium but in 153 pigmented eyes it was higher than that. In the 201 patients, the average decreasing value of MD in 10 years’ period was-8.01±3.66 dB and the value were correlated to retinal pigmentation but not to gender, age or RP family history. CONCLUSION: The rate of MD decline in RP eyes is significantly related to retinal pigmentation. Our study demonstrates the quantitative rate of MD decline in RP patients and the value of MD could well reflect the severity of RP. 展开更多
关键词 RETINITIS pigmentosa mean deviation of VISUAL field VISUAL ACUITY RETINAL PIGMENTATION
Successively bilateral cytomegalovirus retinitis in immunocompromised patient with Good's syndrome
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作者 Feng Hu Yuan Du Xiao-Yan Peng 《国际眼科杂志:英文版》 SCIE CAS 2018年第12期2021-2023,共3页
Dear Editor,Iam Dr.Feng Hu,from the Department of Ophthalmology of Beijing Tongren Hospital,Beijing,China.I write to present a case report of cytomegalovirus retinitis (CMVR)in Good's syndrome (GS).GS is an extrem... Dear Editor,Iam Dr.Feng Hu,from the Department of Ophthalmology of Beijing Tongren Hospital,Beijing,China.I write to present a case report of cytomegalovirus retinitis (CMVR)in Good's syndrome (GS).GS is an extremely rare primary immune-deficiency syndrome,which consists of simultaneous occurrence of hypogammaglobinemia and thymoma,and is characterized by both humoral and cellar immunodeficiency^[1]. 展开更多
关键词 IMMUNOCOMPROMISED Good's SYNDROME BILATERAL CYTOMEGALOVIRUS RETINITIS
伪狂犬病毒脑炎临床观察与脑脊液二代测序鉴定 被引量:7
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作者 赵伟丽 乌依罕 +15 位作者 李红芳 李世英 范思远 吴红龙 李永军 吕艳丽 韩军 张武超 赵焱 李国丽 乔小东 任海涛 朱以诚 彭斌 崔丽英 关鸿志 《中华医学杂志》 CSCD 北大核心 2018年第15期1152-1157,共6页
目的通过对病因未明的脑炎患者的临床评估与脑脊液二代测序(NGS)病原体筛查,诊断伪狂犬病毒(PRV)脑炎,描述其临床特征。方法选择2016年12月至2017年12月基于北京协和医院神经科牵头的脑炎多中心临床登记研究,并根据北京脑炎协助... 目的通过对病因未明的脑炎患者的临床评估与脑脊液二代测序(NGS)病原体筛查,诊断伪狂犬病毒(PRV)脑炎,描述其临床特征。方法选择2016年12月至2017年12月基于北京协和医院神经科牵头的脑炎多中心临床登记研究,并根据北京脑炎协助组脑炎诊断标准入组病因未明的脑炎病例,进一步进行病因筛查,对疑似感染性脑炎而病因未明者行脑脊液二代测序。结果共收集到4例疑似PRV脑炎病例,均为从事生猪与生猪肉产销的人员。急性起病,表现为迅速进展的重症脑炎,癫痫大发作、意识障碍、呼吸障碍,需要ICU救治,3例呼吸机支持。2例合并双侧视网膜炎,神经影像学提示灰质受累为主的坏死性脑炎,受累部位包括边缘系统、基底节区与中脑,无明显出血改变。脑脊液压力升高,脑脊液白细胞升高(6~64)×10^6/L,脑脊液细胞学为淋巴细胞性炎症。对2例患者进行脑脊液NGS,检测到伪狂犬病毒,未检测到其他病原体,其他临床病原学检测结果阴性。阿昔洛韦、静脉免疫球蛋白与激素治疗部分有效,末次随访4例患者的改良Rankin评分分别为3、5、5和6分。结论伪狂犬病毒可感染人而导致脑炎、视网膜炎。对于病因不明的脑炎病例,如果流行病学、临床表现、脑脊液与影像学符合该病,应尽快进行脑脊液PRV核酸检测,及时诊断和治疗。 展开更多
关键词 伪狂犬病毒 脑炎 脑脊液 二代测序 感染 视网膜炎
45例AIDS合并巨细胞病毒性视网膜炎临床特点分析 预览 被引量:1
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作者 梁津 《传染病信息》 2017年第2期104-106,共3页
目的探究AIDS合并巨细胞病毒(cytomegalovirus,CMV)性视网膜炎临床诊断及治疗措施。方法收集2012年2月—2014年2月收治的45例AIDS合并CMV性视网膜炎患者临床资料并进行回顾性分析,分析患者一般资料、临床特征、实验室检查结果、治疗... 目的探究AIDS合并巨细胞病毒(cytomegalovirus,CMV)性视网膜炎临床诊断及治疗措施。方法收集2012年2月—2014年2月收治的45例AIDS合并CMV性视网膜炎患者临床资料并进行回顾性分析,分析患者一般资料、临床特征、实验室检查结果、治疗及转归。结果患者眼部常见的症状为视力下降和视物模糊,分别为41例(91.11%)和23例(51.11%),另有3例(6.67%)发生失明。眼底检查发现视网膜血管炎和视神经炎,分别为31例(68.89%)和5例(11.11%),另有5例(11.11%)发生视网膜脱离。患者CD4+T细胞计数平均为(56.3±12.6)个/μl,CMV-Ig M阳性15例(33.33%),CMV抗原阳性18例(40.00%)。应用替诺福韦+拉米夫定+依非韦伦进行抗病毒治疗后,19例治愈(42.22%),19例好转(42.22%),7例无效(15.56%)。结论 AIDS患者免疫功能缺损,易合并眼部CMV感染造成视网膜炎症,临床以视力下降和视力模糊为主,眼底检查常见为视网膜血管炎和视神经炎,积极治疗可获得显著效果。 展开更多
关键词 艾滋病 巨细胞病毒 视网膜炎
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视网膜色素变性患者脉络膜厚度变化及对视功能的影响
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作者 王慧 温晏 +1 位作者 闫丽 于晓明 《中国基层医药》 CAS 2017年第5期717-720,共4页
目的:探讨视网膜色素变性(RP)患者脉络膜厚度变化及对视功能的影响。方法选取 RP 患者37例62只患眼和健康志愿者30例60只眼作为对照组,利用光相干断层扫描(OCT)的增强深部成像技术(EDI)对眼黄斑中心凹下脉络膜厚度(SFCT)进行... 目的:探讨视网膜色素变性(RP)患者脉络膜厚度变化及对视功能的影响。方法选取 RP 患者37例62只患眼和健康志愿者30例60只眼作为对照组,利用光相干断层扫描(OCT)的增强深部成像技术(EDI)对眼黄斑中心凹下脉络膜厚度(SFCT)进行检测,进行全视野视网膜电图(ERG)检查,记录 ERG 波形变化,按照 T32或 LVC 程序对 RP 患眼进行视野检查,记录平均光敏感度(MS)、平均缺损度(MD)和丢失方差(LV),利用 Pearson 相关分析对变量间相关性进行分析。结果RP 患者患眼 SFCT 为(218.7±62.8)μm,对照组受检眼 SFCT 为(291.5±54.1)μm,协方差分析结果显示,年龄和组别间并无交互作用(F =1.574,P =0.213),两组相比,差异有统计学意义(t =7.347,P 〈0.001);RP 患者 ERG 波潜伏期长于对照组,而振幅低于对照组,差异均有统计学意义(P 〈0.05);BP 患者62只患眼中,明适应反应波形降低26只,无波形36只,波形降低患眼 SFCT 和无波形患眼差异无统计学意义(P 〉0.05);暗适应反应波形降低23只,无波形39只,波形降低患眼 SFCT 和无波形患眼差异无统计学意义(P 〉0.05);接受 T32程序检查的24只患眼 MD、MS、LV和 SFCT 分别为(19.6±6.1)dB、(10.3±5.2)dB、(33.9±14.9)dB2和(212.9±69.8)μm,Pearson 相关分析显示,患眼 SFCT 与 MD 和 LV 均呈负相关(r =-0.502和-0.687,均 P 〈0.05),而与 MS 呈正相关(r =0.551,P =0.005),接受 LVC 程序检查的38只患眼 MS 和 SFCT 分别为(7.4±4.9)dB 和(229.3±64.7)μm, Pearson 相关分析显示,患眼 SFCT 与 MS 无相关性(r =0.108,P =0.519)。结论RP 患者患眼 SFCT 出现了明显减少,但与全视野视网膜电图波形变化无关,与视野检查相关性受患眼中心视力状况影响,中心视力损伤较轻 展开更多
关键词 视网膜炎 色素性 脉络膜 视力试验
获得性免疫缺陷综合征患者房水中细胞因子的检测
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作者 孔文君 郭纯刚 +4 位作者 谢连永 魏文斌 董宏伟 陈超 杜葵芳 《中华眼科杂志》 CSCD 北大核心 2017年第10期746-752,共7页
目的 探讨不同眼部表现的获得性免疫缺陷综合征(AIDS)患者房水中细胞因子的含量变化情况.方法 病例对照研究.选取2013年12月至2015年7月在首都医科大学附属北京佑安医院感染中心及眼科确诊的AIDS患者38例,男性37例,女性1例,平均(33.7... 目的 探讨不同眼部表现的获得性免疫缺陷综合征(AIDS)患者房水中细胞因子的含量变化情况.方法 病例对照研究.选取2013年12月至2015年7月在首都医科大学附属北京佑安医院感染中心及眼科确诊的AIDS患者38例,男性37例,女性1例,平均(33.7±10.0)岁.按眼部表现分为巨细胞病毒视网膜炎(CMVR)组(16例)、人类免疫缺陷病毒(HIV)视网膜病变组(14例)、眼部正常组(8例),分别进行视力(logMAR)、眼压、眼底照相眼科常规检查,同时检测血液中CD4^+T细胞数目,分别对3个组进行前房穿刺抽液,采用Luminex 200液相芯片分析仪测定各组房水中细胞因子的含量.眼压比较采用单因素方差分析.视力、CD4^+T细胞数、细胞因子含量采用Kruskal-Wallis检验,Mann-Whitney U检验比较两组间差异,组间比较行Bonferroni校正.结果 38例患者视力为1.000(0.000,1.000),3个组视力之间的差别具有统计学意义(χ^2=9.963,v=2,P=0.007),CMVR组明显高于视网膜病变组和眼部正常组.3个组患者的眼压为(13.82±3.91)mmHg(1mmHg=0.133 kPa),3个组眼压的差异无统计学意义(F=0.830,P=0.444).3个组CD4^+T细胞数目58(4,550)个/μ1,组间比较差异有统计学意义(χ^2=6.106,v=2,P=0.047),眼部正常组的CD4^+T细胞数明显高于CMVR组和视网膜病变组,CMVR组和视网膜病变组CD4^+T细胞数差异无统计学意义.巨噬细胞炎性蛋白1b(MIP-1b)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血管内皮生长因子(VEGF)、白细胞介素8(IL-8)、单核细胞趋化蛋白1(MCP-1)、干扰素诱导蛋白10(IP-10)的含量在3个组之间的差异有统计学意义,且CMVR组上述7个因子含量明显高于HIV视网膜病变组和眼部正常组.结论 较之于AIDS眼部正常患者和HIV视网膜病变患者,AIDS患者的CMVR严重影响患者视力,3个组在细胞因子MIP-1b、IL-6、TNF-α 、VEGF、IL-8、MCP-1、IP-1 展开更多
关键词 获得性免疫缺陷综合征 眼房水 细胞因子类 视网膜炎
玻璃体腔注射β淀粉样蛋白制作视网膜炎症模型
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作者 雷春燕 汪家名 +2 位作者 郑仕洁 陶丽妃 雷博 《中华眼视光学与视觉科学杂志》 CAS CSCD 2016年第1期8-13,共6页
目的利用玻璃体腔注射β淀粉样蛋白(amyloidβ,Aβ)制作视网膜炎症模型。方法实验研究。分别向25只C57BL/6J小鼠的玻璃体腔注射2μlPBS或不同浓度(0.5、1.0、1.5、2.0μg/μ1)的Aβ1—402μl,24h后检测视网膜神经层(简称为... 目的利用玻璃体腔注射β淀粉样蛋白(amyloidβ,Aβ)制作视网膜炎症模型。方法实验研究。分别向25只C57BL/6J小鼠的玻璃体腔注射2μlPBS或不同浓度(0.5、1.0、1.5、2.0μg/μ1)的Aβ1—402μl,24h后检测视网膜神经层(简称为神经视网膜)中自介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和NLRP3炎性小体的mRNA水平变化确定适宜的A13诱导浓度。确定浓度后,分别向小鼠玻璃体腔注射2μl最适浓度的A1340.1(n=12)、A131—40(n=12),于第1、4、14天检测神经视网膜和视网膜色素上皮(RPE)/脉络膜复合体中IL-6、TNF-α和NLRP3的mRNA水平变化;分别向小鼠玻璃体腔注射2μl最适浓度的PBS(n=3)、Aβ40-1(n=3)和Aβ1-40(n=3),于第4天取眼球行HE染色,光镜下观察视网膜形态改变。于第4、14天对正常对照组(n=12)、Aβ40—1组(n=8)和Aβ1—40组(n=8)行全视野视网膜电图(ERG)检测视网膜功能。用方差分析对各参数进行统计学处理。结果诱导视网膜炎症损伤模型的最适AIM-40浓度为1.0μg/β1。与注射Aβ40—1组相比,Aβ1—40组在神经视网膜和RPE/脉络膜复合体中的IL-6、TNF-α和NLRP3炎性小体的mRNA水平在第l、4天均有明显升高且差异具有统计学意义。而在第14天时,除神经视网膜中的TNF—α外,神经视网膜和RPE/脉络膜复合体中的各炎性因子mRNA水平的差异均无统计学意义。第4天时.各组HE染色均未发现视网膜有明显的结构紊乱和炎性细胞浸润。玻璃体腔注射后第4、14天时,Aβ1—40组小鼠的ERGa波和b波振幅明显低于正常对照组和A1340—1组且差异具有明显统计学意义:而第14天时正常对照组和Aβ40-1组小鼠的ERG振幅差别除在暗适应光刺激强度为1.0、10.0cd·s/m2以外,在其余条件下差异均无统计学意义。结论玻璃体腔注射Aβ1—40可诱导神经视网膜和RPE/脉络膜复合体产 展开更多
关键词 视网膜炎 淀粉样Β蛋白 黄斑变性 小鼠
合并人免疫缺陷病毒感染的梅毒性葡萄膜视网膜炎的临床表现 被引量:2
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作者 张锐 钱江 +1 位作者 王朱健 袁一飞 《中华眼科杂志》 CAS CSCD 北大核心 2015年第10期739-745,共7页
目的 探讨合并人免疫缺陷病毒(HIV)感染的梅毒性葡萄膜视网膜炎患者的临床表现.方法 回顾性系列病例研究.收集2008年1月至2014年12月在复旦大学附属眼耳鼻喉科医院就诊的葡萄膜视网膜炎患者,对其进行梅毒、HIV血清学检查.选择苍白螺... 目的 探讨合并人免疫缺陷病毒(HIV)感染的梅毒性葡萄膜视网膜炎患者的临床表现.方法 回顾性系列病例研究.收集2008年1月至2014年12月在复旦大学附属眼耳鼻喉科医院就诊的葡萄膜视网膜炎患者,对其进行梅毒、HIV血清学检查.选择苍白螺旋体颗粒凝集试验和快速血浆反应素试验(RPR)均为阳性,且RPR> 1:8,同时HIV病毒检测阳性者,排除其他原因引起的葡萄膜视网膜炎.所有患者均行全面的眼部检查,包括最佳矫正视力、眼前节、眼底、眼压及眼部B超检查,除因玻璃体混浊或因全身因素不能耐受者,均行FFA检查,部分患者行OCT检查.同时进行全身检查.结果 共收集病例26例,其中男性24例(92.3%),女性2例(7.7%),就诊年龄为20~63岁,平均(39.3±13.2)岁.RPR滴度为1:32~1:512.其中3例为单眼发病(11.5%),23例为双眼发病(88.5%),共49只眼.最佳矫正视力为0.6至手动.全葡萄膜炎是最常见的表现,39只眼(79.6%),仅出现前葡萄膜炎者2只眼(4.1%),后葡萄膜炎8只眼(16.3%).前房炎症细胞(-)~(+++),玻璃体混浊轻度至重度.眼底病变表现为视神经视网膜炎16只眼(32.7%)、玻璃体炎27只眼(55.1%)、视网膜脉络膜炎5只眼(10.2%)、视神经炎5只眼(10.2%)、视网膜炎5只眼(10.2%),其中包括坏死性视网膜炎2只眼(4.1%)、视网膜血管炎4只眼(8.2%)、后部鳞状脉络膜视网膜炎2只眼(4.1%),多灶性脉络膜炎2只眼(4.1%).5只眼(10.2%)眼压升高.全身表现包括:皮疹5例(19.2%),阴部溃疡5例(19.2%),下疳3例(11.5%),头痛2例(7.7%),双下肢无力2例(7.7%),发热2例(7.7%),口腔溃疡1例(3.8%),脱发1例(3.8%).结论 合并HIV感染的梅毒性葡萄膜视网膜炎的临床表现缺乏特异性,最常见的眼底表现为视神经视网膜炎,多数患者同时伴有玻璃� 展开更多
关键词 HIV感染 梅毒 葡萄膜炎 视网膜炎
肾单位肾痨临床表型与基因突变研究进展 预览 被引量:4
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作者 孙良忠 《广东医学》 CAS 北大核心 2015年第13期1965-1967,共3页
肾单位肾痨(nephronophthisis,NPHP)是一种以肾囊肿形成为主的慢性肾小管间质疾病,属于常染色体隐性遗传病,是儿童和青少年肾衰竭最常见的遗传性因素。在儿童肾衰竭的因素中,NPHP在美国占5%,在英国占6.5%。NPHP的发病率为1/900 000-1/... 肾单位肾痨(nephronophthisis,NPHP)是一种以肾囊肿形成为主的慢性肾小管间质疾病,属于常染色体隐性遗传病,是儿童和青少年肾衰竭最常见的遗传性因素。在儿童肾衰竭的因素中,NPHP在美国占5%,在英国占6.5%。NPHP的发病率为1/900 000-1/50 000,不同地区有较大的差异。加拿大的报道为1/50 000,美国为9/8 300 000, 展开更多
关键词 肾痨 肾单位 临床表型 肾小管间质疾病 基因突变 肾囊肿 眼-脑-肾综合征 婴儿型 RETINITIS 毯层视网膜变性
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Novel variant syndrome associated with congenital hepatic fibrosis 预览
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作者 Yusuf Bayraktar Ozlem Yonem +3 位作者 Kubilay Varli Hande Taylan Ali Shorbagi Cenk Sokmensuer 《世界临床病例杂志》 2015年第10期904-910,共7页
Congenital hepatic fibrosis is part of many different malformation syndromes,of which oculo-encephalohepato-renal syndrome is the most common.These syndromes largely overlap,and so accurate classification of individua... Congenital hepatic fibrosis is part of many different malformation syndromes,of which oculo-encephalohepato-renal syndrome is the most common.These syndromes largely overlap,and so accurate classification of individual patients may be difficult.We present herein three syndromic siblings who were products of a consanguineous marriage.We investigated in detail at least six organ systems in these patients,namely the liver,brain,eye,kidneys,skeleton,and gonads.The common features observed in these three cases were congenital hepatic fibrosis,retinitis pigmentosa,truncal obesity,rotatory nystagmus,mental retardation,advanced myopia,and high-arched palate.The clinical dysmorphology in these patients was distinct and lacked the major features of the known syndromes associated with congenital hepatic fibrosis.Although some features of these presented cases are similar to those found in Bardet-Biedl syndrome(BBS),the absence of some major criteria of BBS(polydactyly,renal abnormality,and hypogonadism)suggests that this may be a new syndrome.All three patients remain under follow-up in the departments of Gastroenterology,Ophthalmology,and Neurology at Hacettepe University. 展开更多
关键词 CONGENITAL hepatic fibrosis NYSTAGMUS Mental RETARDATION RETINITIS pigmentosa High-arched PALATE
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视网膜色素变性患者房水中血管内皮生长因子含量的测定 预览
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作者 陈星 于建春 +3 位作者 周丹英 孙庆祝 吴雁冰 沈健 《中国眼耳鼻喉科杂志》 2015年第5期358-359,共2页
视网膜色素变性(retinitis pigmentosa,RP)是视网膜变性中最普遍的,发生率约为1/4 000[1]。由于光感受器细胞的缺乏,导致视网膜色素上皮的损坏。RP是一种高变异程度的疾病,有的表现为局部视野缺损,有的表现为周边视野缺损,但最终会发... 视网膜色素变性(retinitis pigmentosa,RP)是视网膜变性中最普遍的,发生率约为1/4 000[1]。由于光感受器细胞的缺乏,导致视网膜色素上皮的损坏。RP是一种高变异程度的疾病,有的表现为局部视野缺损,有的表现为周边视野缺损,但最终会发展为黄斑功能的缺损。眼底表现以骨细胞样色素沉着、视网膜血管变细、视盘萎缩为典型特征,视网膜血管改变是眼底改变突出的特征,早期视网膜血管的变细和晚期血管的纤维化变性是RP患者眼底改变的主要特点。 展开更多
关键词 视网膜色素变性 视网膜血管 视野缺损 视网膜色素上皮 pigmentosa RETINITIS 光感受器细胞 变异程度 眼底改变 视网膜神经
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眼内结核的诊断和治疗 预览 被引量:2
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作者 王晓璇 彭惠 《国际眼科杂志》 CAS 2014年第4期663-665,共3页
结核病是在全球范围内发病率和死亡率都很高的一种慢性传染性疾病,并且极易复发。结核病可累及全身多个器官,当感染眼睛时,可引起眼前段、眼后段及眼的附属器官等病变。本文的目的是阐述眼内结核的临床表现,诊断及治疗。
关键词 眼内结核 结核杆菌 葡萄膜炎 视网膜炎
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