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基于超高效液相色谱-质谱联用技术研究婴儿巨细胞病毒肝炎证候实质
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作者 李维薇 杨燕 +6 位作者 戴启刚 徐珊 单进军 谢彤 林丽丽 贺丽丽 汪受传 《中华中医药杂志》 CAS CSCD 北大核心 2019年第5期1881-1887,共7页
目的:从尿液代谢组学层面探讨婴儿巨细胞病毒(HCMV)肝炎患儿湿热内蕴证、脾虚湿困证、气滞血瘀证的证候实质。方法:收集HCMV肝炎湿热内蕴证(44例)、脾虚湿困证(35例)、气滞血瘀证(43例)、正常对照组(40名)患儿,进行生化指标统计分析,同... 目的:从尿液代谢组学层面探讨婴儿巨细胞病毒(HCMV)肝炎患儿湿热内蕴证、脾虚湿困证、气滞血瘀证的证候实质。方法:收集HCMV肝炎湿热内蕴证(44例)、脾虚湿困证(35例)、气滞血瘀证(43例)、正常对照组(40名)患儿,进行生化指标统计分析,同时采用超高效液相色谱-质谱联用技术,对患儿尿液样本进行代谢组学检测,经主成分分析寻找各证型的生物标志物。结果:在生化指标分析中,各证型组在丙氨酸氨基转移酶、门冬氨酸氨基转移酶、总胆红素、结合胆红素、总胆汁酸、谷氨酰转肽酶、碱性磷酸酶、乳酸脱氢酶及凝血酶原时间水平有显著差异。在代谢组学研究中,各证型组在正交偏最小二乘法-判别分析图上区分明显。各证型组均涉及氨基酸代谢紊乱。此外,各证型均有特征性生物标志物。结论:HCMV肝炎湿热内蕴证、脾虚湿困证及气滞血瘀证在生化指标和尿液代谢物水平均存在显著差异,表明不同中医证候有其生物学基础。 展开更多
关键词 婴儿巨细胞病毒肝炎 证候 代谢组学 湿热内蕴证 脾虚湿困证 气滞血瘀证
尘肺病中医证候和证素分布规律的文献研究
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作者 谢洋 赵虎雷 +1 位作者 王佳佳 李建生 《中医学报》 CAS 2019年第5期1117-1120,共4页
目的:基于文献分析探讨尘肺病中医证候要素的分布规律。方法:从中国知网、中国生物医学文献数据库、万方数据库和维普网数据库中检索相关文献,并对文献信息进行收集整理,采用SPSS 20.0统计学软件包进行统计描述的分析。结果:频率较高的... 目的:基于文献分析探讨尘肺病中医证候要素的分布规律。方法:从中国知网、中国生物医学文献数据库、万方数据库和维普网数据库中检索相关文献,并对文献信息进行收集整理,采用SPSS 20.0统计学软件包进行统计描述的分析。结果:频率较高的证型依次为燥邪伤肺证(8.28%)、肺阴虚证(7.64%)、肺气虚证(7.64%)、肺脾气虚证(7.01%)和痰湿阻肺证(7.01%)。构成尘肺病的中医证候要素有20个,病性证素中以气虚(30.57%)、阴虚(24.20%)和痰(21.66%)为主,病位证素中以肺(63.69%)为主;在证素组合中,以两证素和三证素组合最常见,累计频率为(89.18%)。单一病性证素中,气虚、阴虚和燥邪出现的频率较高,其频率分别为34.88%、18.60%和15.12%;两病性组合时,气虚+阴虚、痰+湿、痰+瘀和痰+热出现的频率较高,其频率分别为28.57%、17.46%、14.29%和9.52%。结论:尘肺病的主要病理因素以燥邪、气虚、阴虚和痰为主,病位主要在肺。 展开更多
关键词 尘肺 证候 病位证素 病性证素 文献研究
Contribution of ghrelin to functional gastrointestinal disorders’pathogenesis 预览
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作者 Tilemachos Koutouratsas Theodora Kalli +1 位作者 Georgios Karamanolis Maria Gazouli 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期539-551,共13页
Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology re... Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology remains obscure and,although it is expected to differ according to the specific FGID,disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis.The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions,including regulation of gastrointestinal motility and protection of mucosal tissue.Ghrelin’s gene shows genetic polymorphism,while its protein product undergoes complex regulation and metabolism in the human body.Numerous studies have studied ghrelin’s relation to the emergence of FGIDs,its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment.Despite the mixed results currently available in scientific literature,the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis.The aim of this paper is to review current literature studying these associations,in an effort to uncover certain patterns of alterations in both genetics and expression,which could delineate its true contribution to FGID emergence,either as a causative agent or as a pathogenetic intermediate. 展开更多
关键词 FUNCTIONAL GASTROINTESTINAL disorders FUNCTIONAL colonic diseases Irritable bowel SYNDROME Cyclic VOMITING SYNDROME Infantile COLIC GASTROINTESTINAL disease GHRELIN Genetics Epigenetic processes
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短期大剂量氢化可的松诱发小鼠药源性证候的评价研究
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作者 李亚 潘志强 +1 位作者 钱宏梁 方肇勤 《上海中医药大学学报》 CAS 2019年第2期55-60,65共7页
目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·... 目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·kg^-1·d^-1组),每组8只。氢化可的松不同剂量组小鼠分别灌胃给予相应浓度的氢化可的松溶液,对照组小鼠灌胃给予相同体积灭菌水,连续5 d。分别于给药第1、3、5天称量每只小鼠体质量。末次给药后,采用课题组前期建立的小鼠辨证论治实验方法学检测小鼠表征信息(躯体不同部位红外温度、腋温、抓力);取各只小鼠胸腺、脾脏称重,计算脏器指数;分离肾上腺组织,实时荧光定量PCR技术检测类固醇激素合成酶(Star、Cyp11a1、Cyp21a1、Cyp11b1)基因表达,Western blot检测StAR、SRBI与LDLR蛋白表达。结果:①给药1、3、5 d后,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组小鼠的体质量均较对照组显著降低(P<0.05,P<0.01)。②给药5 d后,氢化可的松12.5 mg·kg^-1·d^-1和25 mg·kg^-1·d^-1组小鼠的头部最高温度均较对照组显著降低(P<0.05),但氢化可的松各剂量组小鼠的躯干平均温度、尾部最低温度、腋温、抓力无明显变化。③与对照组相比,氢化可的松各剂量组小鼠的脾脏指数均明显下降(P<0.01),且呈剂量依赖性;50 mg·kg^-1·d^-1组小鼠的胸腺指数较对照组显著降低(P<0.01)。④与对照组相比,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组肾上腺组织中Star、Cyp11a1、Cyp11b1和Cyp21a1的mRNA表达均显著减少(P<0.05,P<0.01),StAR、LDLR和SRBI蛋白表达均显著降低(P<0.05,P<0.01)。结论:大剂量氢化可的松(25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1)短期给药5 d可显著抑制小鼠肾上腺皮质功能,其证候表现以药源性阴虚证为主。 展开更多
关键词 氢化可的松 肾上腺皮质 证候 阴虚证 小鼠
Novel mutation in OCRL leading to a severe form of Lowe syndrome
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作者 Feng-Qi Zhou Qi-Wei Wang +5 位作者 Zhen-Zhen Liu Xu-Lin Zhang Dong-Ni Wang Mei-Mei Dongye Hao-Tian Lin Wei-Rong Chen 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1057-1060,共4页
AIM: To investigate the phenotype and genotype of a family with X-linked recessive Lowe syndrome. METHODS: All the members in the Chinese pedigree underwent comprehensive ophthalmologic and systemic examinations. Geno... AIM: To investigate the phenotype and genotype of a family with X-linked recessive Lowe syndrome. METHODS: All the members in the Chinese pedigree underwent comprehensive ophthalmologic and systemic examinations. Genomic DNA was isolated from peripheral blood of the pedigree members and 100 unrelated healthy Chinese subjects. Direct sequencing was performed to screen the exons and intron boundaries of OCRL.RESULTS: The ophthalmological and systemic exami nations suggested that the affected individual had Lowe syndrome. The phenotype in the pedigree is severe and consistent among all the affected individuals except for an individual who additionally suffered from congenital heart disease and laryngeal cartilage dysplasia. Directio nal San ger sequenci ng identified a complex mutation c.(2368_2368delG;c.2370A>C) in the Rho-GTPase activating protein domain. This complex mutation causes termination of protein synthesis at amino acid 824 and result in a new peptide with 823 amino acids (p.Ala790ProfsX34). This mutation was not detected in 100 unrelated healthy Chinese subjects.CONCLUSION: Our findings expand the phenotypic and genotypic spectrum of Lowe syndrome. 展开更多
关键词 LOWE SYNDROME oculocerebrorenal SYNDROME OCRL CONGENITAL MEMBRANOUS CATARACT
A review of Behcet’s disease from the perspectives of both Western and Chinese Medicine
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作者 Zhang Jing Tang Yuping +5 位作者 Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期139-148,共10页
Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characte... Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet’s disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East.This article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet’s disease. Furthermore, the etiology of Behcet’s disease will be evaluated from the aspect of Traditional Chinese Medicine(TCM) syndrome differentiation. As Behcet’s disease is complex and intractable, its treatment warrants further research.Traditionally, Behcet’s disease is treated with Western Medicine(WM) via medications that act locally and systemically;this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet’s disease via a combination of WM and TCM.Recent studies have indicated that such a combination of Chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet’s disease, and to outline its possible pathogenesis in terms of both TCM and WM. Based on these findings, the present review proposes a Behcet’s disease treatment protocol composed of a combination of Chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication. 展开更多
关键词 Behcet SYNDROME SYNDROME differentiation treatment VIRULENCE RECURRENCE THERAPEUTICS Review
A rare case of non-ST-segment elevation myocardial infarction triggered by coronary subclavian steal syndrome 预览
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作者 Xiao-Qing CAI Feng TIAN +7 位作者 Shan-Shan ZHOU Jing JING Wei HU Tao ZHANG Xi WANG Ri-Na DU Qiang XU Yun-Dai CHEN 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第4期378-380,共3页
Coronary subclavian steal syndrome (CSSS) has been recognized lately as an unusual clinical entity,giving rise to angina but rarely causing an acute coronary syndrome (ACS). The prerequisites for the appearance of CSS... Coronary subclavian steal syndrome (CSSS) has been recognized lately as an unusual clinical entity,giving rise to angina but rarely causing an acute coronary syndrome (ACS). The prerequisites for the appearance of CSSS are both a patent left internal mammary artery (LIMA) graft and severe stenosis of the left subclavian artery (LSA). However,LSA is often overlooked in the diagnostic evaluation of patients with angina,who have underwent coronary artery bypass grafting (CABG). We report an unusual case of non-ST-segment elevation myocardial infarction (NSTEMI) caused by subtotal occlusion of proximal LSA. 展开更多
关键词 Acute CORONARY SYNDROME CORONARY artery BYPASS GRAFTING CORONARY SUBCLAVIAN steal SYNDROME PERCUTANEOUS CORONARY intervention
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Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients
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作者 ZHAO Hai-ping LIU Ping +3 位作者 XU Chang-min LI Guang-wen GAO Li LUO Yu-min 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第8期590-597,共8页
Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two s... Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two syndrome types in acute ischemic stroke patients. Methods: A microarray assay was performed to assess the expression pattern of miRNAs in the lymphocyte of acute ischemic stroke patients. Target genes for the deregulated miRNAs were predicated using the online bioinformatic algorithms and functional annotation via Kyoto encyclopedia of genes and genomes pathway analysis for miRNAs predicted targets was carried out. Based on the predicted target genes of differentially expressed miRNAs, the miRNA-gene-network and miRNA-pathway network were constructed. Results: Yang score based on tongue texture, urine, dejecta, and appearance, etc. showed that clinical symptoms were distinct between yang and yin syndromes. There were significantly higher total leukocyte number and lower total protein level in patients with yang syndrome compared with those in patients with yin syndrome (P<0.05). Comprehensive miRNA analysis identified 36 unique down-regulated miRNAs in yang syndrome group, and 20 unique down-regulated and 2 unique up-regulated miRNAs in yin syndrome group. The key regulatory miRNAs, gene, and pathways in the yang syndrome were hsa-miR-93-5p and -320b, enabled homolog, the metabolic pathways and mitogen-activated protein kinase signaling pathways, respectively, while those in the yin syndrome were hsa-miR-424-5p and -106b-5p, CNOT4, hepatitis B and pathways in cancer, respectively. Conclusion: These results offered insight into the molecular basis underlying the different pathogenesis of yang or yin syndrome, providing clues for the individualized therapeutic strategies of acute ischemic stroke. 展开更多
关键词 acute ISCHEMIC stroke yang SYNDROME YIN SYNDROME MICRORNAS profile diagnosis Chinese medicine
Chemical screen identifies a geroprotective role of quercetin in premature aging
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作者 Lingling Geng Zunpeng Liu +12 位作者 Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2019年第6期417-435,共19页
Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for ge... Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. 展开更多
关键词 QUERCETIN STEM cell AGING Werner SYNDROME Hutchinson-Gilford progeria SYNDROME
基于1205例文献病例的发作性睡病中医证候及证候要素研究
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作者 郎奕 冯淬灵 +2 位作者 白文 戴中 杨嘉颐 《时珍国医国药》 CAS CSCD 北大核心 2019年第3期754-755,共2页
目的探讨发作性睡病证候及证候要素的分布规律。方法对中国期刊全文数据库(1979年~2017年)、万方数据库(1990年~2017年)的全部期刊进行检索,对符合要求的发作性睡病证候进行规范,提取证候要素,原始数据用EpiData 2.0建立数据库,运用SPSS... 目的探讨发作性睡病证候及证候要素的分布规律。方法对中国期刊全文数据库(1979年~2017年)、万方数据库(1990年~2017年)的全部期刊进行检索,对符合要求的发作性睡病证候进行规范,提取证候要素,原始数据用EpiData 2.0建立数据库,运用SPSS 13.0进行频数、构成比统计。结果共纳入73篇文献,1205例发作性睡病患者,发作性睡病最常见的证候依次是肝郁气滞证369例(30.62%),风痰扰神证315例(26.14%),脾虚湿困证297例(24.65%);提取病性类证候要素15个,最常见的依次为痰519例(43.07%),气虚518例(42.99%),湿404例(33.53%),气滞377例(31.29%),动风369例(30.62%);病位类证候要素10个,最常见的依次为脾652例(54.11%),肝386例(32.03%),脑315例(26.14%)。结论基于文献的发作性睡病证候及证候要素研究,初步反映了本病的证候及证候要素分布规律,可为进一步确定发作性睡病的中医辨证分型标准提供参考和依据。 展开更多
关键词 发作性睡病 证候 证候要素 文献研究
Spectrum of gastrointestinal involvement in Stevens-Johnson syndrome 预览
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作者 Ashish Kumar Jha Arya Suchismita +1 位作者 Rajeev Kumar Jha Vikas Kumar Raj 《世界胃肠内镜杂志:英文版(电子版)》 2019年第2期115-123,共9页
Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus ... Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus membrane lesions usually involve the oral cavity,lips,bulbar conjunctiva and the anogenitalia.The oral/anal mucosa and liver are commonly involved in SJS or TEN.However,intestinal involvement is distinctly rare.We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN.This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN. 展开更多
关键词 STEVENS-JOHNSON SYNDROME TOXIC EPIDERMAL necrolysis Lyell’s SYNDROME Gastrointestinal involvement COLON ILEUM
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Exploratory metabolomics of metabolic syndrome:A status report 预览
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作者 Daniella Lent-Schochet Matthew McLaughlin +1 位作者 Neeraj Ramakrishnan Ishwarlal Jialal 《世界糖尿病杂志:英文版(电子版)》 2019年第1期23-36,共14页
Metabolic syndrome(MetS)is as a cluster of cardio-metabolic factors that greatly increase the risk of chronic diseases such as type II diabetes mellitus and atherosclerotic cardiovascular disease.In the United States,... Metabolic syndrome(MetS)is as a cluster of cardio-metabolic factors that greatly increase the risk of chronic diseases such as type II diabetes mellitus and atherosclerotic cardiovascular disease.In the United States,obesity,physical inactivity,aging,and genetics(to a minor extent)have arisen as risk factors for developing MetS.Although 35%of American adults suffer from MetS,its pathogenesis largely remains unknown.Worse,there is a lack of screening and optimum therapy for this disease.Researchers have consequently turned towards metabolomics to identify biomarkers to better understand MetS.The purpose of this review is to characterize various metabolites and their potential connections to MetS.Numerous studies have also characterized MetS as a disease of increased inflammation,and therefore this review also explores how metabolites play a role in various inflammatory pathways.Our review explores a broad range of metabolites including biogenic amines,branched chain amino acids,aromatic amines,phosphatidylcholines,as well as a variety of other molecules.We will explore their biochemical pathways and their potential role in serving as biomarkers. 展开更多
关键词 METABOLIC SYNDROME SYNDROME X Metabolomics Amino ACIDS CARNITINE Inflammation Biomarkers Diabetes
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Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis 预览
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作者 Ya-Li Zhang Li-Ting Cai +9 位作者 Jun-Yi Qi Yun-Zheng Lin Yan-Cheng Dai Na Jiao You-Lan Chen Lie Zheng Bei-Bei Wang Li-Xin Zhu Zhi-Peng Tang Rui-Xin Zhu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第25期3242-3255,共14页
BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndrome... BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostr 展开更多
关键词 ULCERATIVE colitis Intestinal MICROBIOTA Pi-Xu-Shi-Yun SYNDROME Da-Chang-Shi-Re SYNDROME Traditional Chinese medicine
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从“水饮”论治癫痫的机制探讨 预览
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作者 刘冲冲 孙江燕 +1 位作者 袁斯远 刘金民 《环球中医药》 CAS 2019年第6期862-866,共5页
本文探讨了中医对癫痫病因病机的认识,提出“水饮”是癫痫病因之一。笔者梳理了水饮证的历史源流及形成机理,通过比较癫痫与水饮致病特点之间的内在联系,得出水饮证可以导致癫痫证候的观点,而水饮诱发癫痫发作的内在机制在于水饮上冲,... 本文探讨了中医对癫痫病因病机的认识,提出“水饮”是癫痫病因之一。笔者梳理了水饮证的历史源流及形成机理,通过比较癫痫与水饮致病特点之间的内在联系,得出水饮证可以导致癫痫证候的观点,而水饮诱发癫痫发作的内在机制在于水饮上冲,并通过相关医案验证了从水饮上冲辨治癫痫的可行性。本文通过探索水饮与癫痫之间的内在联系,希望借此丰富中医相关理论,为临床辨治癫痫提供新的思路。 展开更多
关键词 癫痫 病机 证候 水饮证 水饮上冲 医案
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影响证候转化的因素及与疾病预后的关系 预览
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作者 周小青 郑彩杏 《湖南中医药大学学报》 CAS 2019年第1期1-5,共5页
精准医疗,要求诊断的精细观察。除了已经被重视的精准辨证诊病外,证候转化的细致观察应当引起重视。在疾病过程中,证候可有好转或恶化两种转归情况。证候转化,是疾病向愈或恶化的转折处,也是检验辨治正确与否的标准之一。临床中,影响证... 精准医疗,要求诊断的精细观察。除了已经被重视的精准辨证诊病外,证候转化的细致观察应当引起重视。在疾病过程中,证候可有好转或恶化两种转归情况。证候转化,是疾病向愈或恶化的转折处,也是检验辨治正确与否的标准之一。临床中,影响证候转化的因素举不胜举,而证候转化方向提示疾病预后。笔者从疾病的病位、病性、患者的体质等角度阐述影响证候转化的因素,探讨证候转化与疾病预后的相关问题,期望有利于精准诊疗。 展开更多
关键词 证候 证候转化 病位 病性 体质 精准医疗
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当代名中医治疗溃疡性结肠炎经验集萃 预览
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作者 钟晨 王佳佳 +2 位作者 迟莉 巴寅颖 王智瑜 《中国医药导报》 CAS 2019年第4期137-140,共4页
溃疡性结肠炎(UC)是一种慢性难治性肠道炎症疾病,其病因尚未明确,临床治疗复杂,严重影响患者生存质量。当代名中医治疗溃疡性结肠炎积累了丰富的临床经验,认为UC发病以脾虚湿蕴为基本病机,涉及气滞、瘀血、痰浊、寒湿、毒疫、伏毒、血... 溃疡性结肠炎(UC)是一种慢性难治性肠道炎症疾病,其病因尚未明确,临床治疗复杂,严重影响患者生存质量。当代名中医治疗溃疡性结肠炎积累了丰富的临床经验,认为UC发病以脾虚湿蕴为基本病机,涉及气滞、瘀血、痰浊、寒湿、毒疫、伏毒、血热等。证候类型主要有肝郁脾虚证、脾气亏虚证、脾虚湿蕴证、气滞血瘀证、脾肾阳虚证、大肠湿热证、热毒炽盛证等。临床治疗注重将临床分期与辨证论治相结合,消补兼施,内外结合,取得了显著的临床疗效。 展开更多
关键词 溃疡性结肠炎 病因病机 证候 辨证 灌肠
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小儿手足口病中医证候演变规律的研究
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作者 王有鹏 刘璐佳 +3 位作者 曲婉莹 杨阳 景伟超 刘志伟 《辽宁中医杂志》 CAS 2019年第3期521-524,共4页
目的:分析黑龙江地区小儿手足口病各证型演变规律,提出治疗方案。方法:通过收集患儿临床资料,观察入院当天(基线点)、治疗后第3、5、7、10天的临床表现,确定各观察点中医分型,统计不同观察点各证型演变规律。应用证候演变概率法对患儿... 目的:分析黑龙江地区小儿手足口病各证型演变规律,提出治疗方案。方法:通过收集患儿临床资料,观察入院当天(基线点)、治疗后第3、5、7、10天的临床表现,确定各观察点中医分型,统计不同观察点各证型演变规律。应用证候演变概率法对患儿各证候在不同观察点的证候演变规律进行系统分析,并提出相应治疗方案。结果:从基线点当天的发病数量来看,邪犯肺卫证和肺胃热炽证的发病人数居多,从基线点到第3天,以证候的持续存在概率较为突出,其中,湿热交阻证持续存在概率为89. 17%,心脾积热证持续存在概率为84. 41%。第3~5天,邪犯肺卫证及肺胃热炽证发病人数仍较多,且以邪犯肺卫证的持续存在概率较为明显。第5~7天,各证候的持续存在概率大幅度下降的同时,转愈及向肺胃阴伤证的概率增大。第7~10天,剩余患儿仍存在向肺胃阴伤证及其他证型转变的情况。结论:手足口病患儿在各观察点存在不同的演变规律,证实了本病符合温病转归的同时,作者提出了相应的治疗方案。 展开更多
关键词 手足口病 证候 演变规律 治疗
基于因子分析和复杂网络技术的溃疡性结肠炎证素分布特点研究 预览
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作者 刘艳 李毅 +4 位作者 高麦仓 孙婳 唐梦凡 李东阳 李盼盼 《现代中西医结合杂志》 CAS 2019年第17期1825-1828,1833共5页
目的探讨因子分析和复杂网络技术用于溃疡性结肠炎中医证候研究的价值。方法采用自拟《溃疡性结肠炎中医证候流行病学调查表》收集706例溃疡性结肠炎患者的中医症状体征和舌脉表现,并行因子分析和复杂网络技术分析。结果经因子分析、复... 目的探讨因子分析和复杂网络技术用于溃疡性结肠炎中医证候研究的价值。方法采用自拟《溃疡性结肠炎中医证候流行病学调查表》收集706例溃疡性结肠炎患者的中医症状体征和舌脉表现,并行因子分析和复杂网络技术分析。结果经因子分析、复杂网络技术相结合提取出证素12个,病位证素包括肠、脾、肝、肾,病性证素包括湿热、寒湿、风寒、气滞、气虚、阳虚、阴虚、血瘀,常见证候类型为寒滞胃肠证、大肠湿热证、寒湿内盛证、脾胃虚弱证、肝郁脾虚证、脾肾阳虚证、阴虚肠燥证、血瘀肠络证。结论因子分析和复杂网络技术相结合的数理统计方法可用于溃疡性结肠炎证候证素分布特点研究,更能直观、简洁地阐明该病的证候特点,为该病的证候研究提供了一种新的方法。 展开更多
关键词 溃疡性结肠炎 证候 证素 因子分析 复杂网络技术
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Gastrointestinal infection-related disseminated intravascular coagulation mimicking Shiga toxin-mediated hemolytic uremic syndrome - implications of classical clinical indexes in making the diagnosis: A case report and literature review 预览
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作者 Xiang-Yang Li Yan-Fen Mai +1 位作者 Jing Huang Pearl Pai 《世界临床病例杂志》 2019年第13期1660-1670,共11页
BACKGROUND Thrombocytopenia associated with acute kidney injury is a challenging disorder. Thrombotic microangiopathy (TMA) is a potentially life- or organ-threatening syndrome that can be induced by several disorders... BACKGROUND Thrombocytopenia associated with acute kidney injury is a challenging disorder. Thrombotic microangiopathy (TMA) is a potentially life- or organ-threatening syndrome that can be induced by several disorders or medical interventions. There is overlap between the clinical presentation and pathophysiology of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome (HUS), and to a lesser extent, disseminated intravascular coagulation (DIC). We describe a case to illustrate the potential diagnostic difficulty, especially at initial presentation. CASE SUMMARY We reported a case of a 44-year-old woman that presented with diarrhea, thrombocytopenia, schistocytes, elevated serum lactate dehydrogenase (LDH) level and acute kidney injury. While the clinical presentation resembled that of Shiga toxin–induced HUS, the disease course was more consistent with gastrointestinal infection-related DIC. To aid in the accurate diagnosis of TMA and other associated disorders, we have undertaken a review and provided a clear interpretation of some typical biomarkers including schistocytes, LDH and platelet count, coagulation profile and more specific indexes of ADAMTS13, complement profile, and the isolation of Shiga toxin-producing Escherichia coli (commonly referred to as STEC). CONCLUSION The use and correct interpretation of classical indexes of schistocyte, LDH, and platelet count is vital in diagnosing TMA and associated disorders. Understanding the characteristics of these biomarkers in the context of thrombocytopenia purpura, HUS and DIC will facilitate the accurate diagnosis and early initiation of appropriate treatment. 展开更多
关键词 THROMBOTIC MICROANGIOPATHY THROMBOTIC THROMBOCYTOPENIC PURPURA HEMOLYTIC UREMIC syndrome Schistocyte Lactate dehydrogenase Thrombocytopenia Case report
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Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values 预览
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作者 Pierluigi Marzuillo Stefano Guarino +5 位作者 Tiziana Esposito Anna Di Sessa Sara Immacolata Orsini Daniela Capalbo Emanuele Miraglia del Giudice Angela La Manna 《世界临床病例杂志》 2019年第9期1021-1027,共7页
BACKGROUND In paediatric patients with complicated nephrotic syndrome (NS), rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G (IgG) levels... BACKGROUND In paediatric patients with complicated nephrotic syndrome (NS), rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G (IgG) levels. AIM To evaluate the effect of RTX on IgG levels and infections in patients with complicated NS and normal basal IgG levels. METHODS We consecutively enrolled all patients with complicated NS and normal basal IgG levels undergoing the first RTX infusion from January 2008 to January 2016. Basal IgG levels were dosed after 6 wk of absent proteinuria and with a maximal interval of 3 mo before RTX infusion. The primary outcome was the onset of IgG hypogammaglobulinemia during the follow-up according to the IgG normal values for age [mean ± standard deviation (SD)]. RESULTS We enrolled 20 patients with mean age at NS diagnosis of 4.2 ± 3.3 years. The mean age at the first RTX infusion was 10.9 ± 3.5 years. Eleven out of twenty patients (55%) developed IgG hypogammaglobulinemia. None of these patients showed severe or recurrent infections. Only one patient suffered from recurrent acute otitis media and underwent substitutive IgG infusion. Three patients undergoing only the two “starting doses” experienced normalization of IgG levels. Using Kaplan-Meier analysis, the cumulative proportion of patients free of IgG hypogammaglobulinemia was 57.8% after the first RTX dose, 51.5% after the third dose, 44.1% after the fourth dose, and 35.5% after the fifth dose.CONCLUSION RTX can induce IgG hypogammaglobulinemia in patients with pre-RTX IgG normal values. None of the treated patients showed severe infections. 展开更多
关键词 Nephrotic SYNDROME RITUXIMAB IGG hypogammaglobulinemia IMMUNOGLOBULIN
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