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Novel miRNA,miR-sc14,promotes Schwann cell proliferation and migration 预览
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作者 Xi-Meng Ji Shan-Shan Wang +5 位作者 Xiao-Dong Cai Xing-Hui Wang Qian-Yan Liu Pan Wang Zhang-Chun Cheng Tian-Mei Qian 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1651-1656,共6页
MicroRNAs refer to a class of endogenous,short non-coding RNAs that mediate numerous biological functions.MicroRNAs regulate various physiological and pathological activities of peripheral nerves,including peripheral ... MicroRNAs refer to a class of endogenous,short non-coding RNAs that mediate numerous biological functions.MicroRNAs regulate various physiological and pathological activities of peripheral nerves,including peripheral nerve repair and regeneration.Previously,using a rat sciatic nerve injury model,we identified many functionally annotated novel microRNAs,including miR-sc14.Here,we used real-time reverse transcription-polymerase chain reaction to examine miR-sc14 expression in rat sciatic nerve stumps.Our results show that miRsc14 is noticeably altered following sciatic nerve injury,being up-regulated at 1 day and diminished at 7 days.EdU and transwell chamber assay results showed that miR-sc14 mimic promoted proliferation and migration of Schwann cells,while miR-sc14 inhiThe study was approved by the Jiangsu Provincial Laboratory Animal Management Committee,China on March 4,2015(approval No.20150304-004).bitor suppressed their proliferation and migration.Additionally,bioinformatic analysis examined potential target genes of miR-sc14,and found that fibroblast growth factor receptor 2 might be a potential target gene.Specifically,our results show changes of miR-sc14 expression in the sciatic nerve of rats at different time points after nerve injury.Appropriately,up-regulation of miR-sc14 promoted proliferation and migration of Schwann cells.Consequently,miR-sc14 may be an intervention target to promote repair of peripheral nerve injury.The study was approved by the Jiangsu Provincial Laboratory Animal Management Committee,China on March 4,2015(approval No.20150304-004). 展开更多
关键词 NERVE REGENERATION novel microRNAs miR-sc14 PERIPHERAL NERVE injury cell PROLIFERATION cell MIGRATION Schwann cells fibroblast growth factor receptor 2 biological functions PERIPHERAL NERVE REGENERATION regulatory mechanisms neural REGENERATION
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A method to deliver patterned electrical impulses to Schwann cells cultured on an artificial axon 预览
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作者 Antonio Merolli Yong Mao +3 位作者 Gregory Voronin Joseph A.M.Steele N.Sanjeeva Murthy Joachim Kohn 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1052-1059,共8页
Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns.Schwann cells in peripheral nerves receive ... Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns.Schwann cells in peripheral nerves receive molecular signals from axons to coordinate the process of myelination.There is evidence,however,that non-molecular signals play an important role in myelination in the form of patterned electrical impulses generated by neuronal activity.The role of patterned electrical impulses has been investigated in the literature using co-cultures of neurons and myelinating cells.The co-culturing method,however,prevents the uncoupling of the direct effect of patterned electrical impulses on myelinating cells from the indirect effect mediated by neurons.To uncouple these effects and focus on the direct response of Schwann cells,we developed an in vitro model where an electroconductive carbon fiber acts as an artificial axon.The fiber provides only the biophysical characteristics of an axon but does not contribute any molecular signaling.In our“suspended wire model”,the carbon fiber is suspended in a liquid media supported by a 3D printed scaffold.Patterned electrical impulses are generated by an Arduino 101 microcontroller.In this study,we describe the technology needed to set-up and eventually replicate this model.We also report on our initial in vitro tests where we were able to document the adherence and ensheath of human Schwann cells to the carbon fiber in the presence of patterned electrical impulses(hSCs were purchased from ScienCell Research Laboratories,Carlsbad,CA,USA;ScienCell fulfills the ethic requirements,including donor’s consent).This technology will likely make feasible to investigate the response of Schwann cells to patterned electrical impulses in the future. 展开更多
关键词 Schwann cell carbon fiber MYELINATION ELECTRICAL impulse artificial AXON in vitro system Arduino MICROCONTROLLER MYELIN basic protein
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Gene expression changes in dorsal root ganglia following peripheral nerve injury:roles in inflammation,cell death and nociception 预览
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作者 Sarah L. Martin Adam J. Reid +2 位作者 Alexei Verkhratsky Valerio Magnaghi Alessandro Faroni 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期939-947,共9页
Subsequent to a peripheral nerve injury,there are changes in gene expression within the dorsal root ganglia in response to the damage.This review selects factors which are well-known to be vital for inflammation,cell ... Subsequent to a peripheral nerve injury,there are changes in gene expression within the dorsal root ganglia in response to the damage.This review selects factors which are well-known to be vital for inflammation,cell death and nociception,and highlights how alterations in their gene expression within the dorsal root ganglia can affect functional recovery.The majority of studies used polymerase chain reaction within animal models to analyse the dynamic changes following peripheral nerve injuries.This review aims to highlight the factors at the gene expression level that impede functional recovery and are hence are potential targets for therapeutic approaches.Where possible the experimental model,specific time-points and cellular location of expression levels are reported. 展开更多
关键词 Gene expression polymerase chain reaction dorsal root GANGLIA INFLAMMATION NOCICEPTION cell death peripheral NERVE injury Schwann CELLS satellite GLIAL CELLS NERVE regeneration
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3-N-Butylphthalide mitigates high glucose-induced injury to Schwann cells:association with nitrosation and apoptosis 预览
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作者 Dan-Dan Xu Wen-Ting Li +4 位作者 Dan Jiang Huai-Guo Wu Ming-Shan Ren Mei-Qiao Chen Yuan-Bo Wu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第3期513-518,共6页
A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic pe... A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic peripheral neuropathy. Therefore, this study investigated the effects of high glucose on proliferation, apoptosis, and 3-nitrotyrosine levels of Schwann cells treated with butylphthalide. In addition, we explored potential protective mechanisms of butylphthalide on peripheral nerves. Schwann cells were cultured in vitro with high glucose then stimulated with the peroxynitrite anion inhibitors uric acid and 3-n-butylphthalide for 48 hours. Cell Counting Kit-8 and flow cytometry were used to investigate the effects of uric acid and 3-n-butylphthalide on proliferation and apoptosis of Schwann cells exposed to a high glucose environment. Effects of uric acid and 3-n-butylphthalide on levels of 3-nitrotyrosine in Schwann cells were detected by enzyme-linked immunosorbent assay. The results indicated that Schwann cells cultured in high glucose showed decreased proliferation, but increased apoptosis and intracellular 3-nitrotyrosine levels. However, intervention with uric acid or 3-n-butylphthalide could increase proliferation of Schwann cells cultured in high glucose, and inhibited apoptosis and intracellular 3-nitrotyrosine levels. According to our data, 3-n-butylphthalide may inhibit cell nitrification and apoptosis, and promote cell proliferation, thereby reducing damage to Schwann cells caused by high glucose. 展开更多
关键词 nerve REGENERATION Schwann cells 3-N-BUTYLPHTHALIDE 3-NITROTYROSINE nitration stress uric acid PEROXYNITRITE anions diabetic peripheral neuropathy APOPTOSIS proliferation neural REGENERATION
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Increased levels of miR-3099 induced by peripheral nerve injury promote Schwann cell proliferation and migration 预览
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作者 Qian-Yan Liu Yang Miao +3 位作者 Xing-Hui Wang Pan Wang Zhang-Chun Cheng Tian-Mei Qian 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第3期525-531,共7页
MicroRNAs (miRNAs) can regulate the modulation of the phenotype of Schwann cells. Numerous novel miRNAs have been discovered and identified in rat sciatic nerve segments, including miR-3099. In the current study, miR-... MicroRNAs (miRNAs) can regulate the modulation of the phenotype of Schwann cells. Numerous novel miRNAs have been discovered and identified in rat sciatic nerve segments, including miR-3099. In the current study, miR-3099 expression levels following peripheral nerve injury were measured in the proximal stumps of rat sciatic nerves after surgical crush. Real-time reverse transcription-polymerase chain reaction was used to determine miR-3099 expression in the crushed nerve segment at 0, 1, 4, 7, and 14 days post sciatic nerve injury, which was consistent with Solexa sequencing outcomes. Expression of miR-3099 was up-regulated following peripheral nerve injury. EdU and transwell chamber assays were used to observe the effect of miR-3099 on Schwann cell proliferation and migration. The results showed that increased miR-3099 expression promoted the proliferation and migration of Schwann cells. However, reduced miR-3099 expression suppressed the proliferation and migration of Schwann cells. The potential target genes of miR-3099 were also investigated by bioinformatic tools and high-throughput outcomes. miR-3099 targets genes Aqp4, St8sia2, Tnfsf15, and Zbtb16 and affects the proliferation and migration of Schwann cells. This study examined the levels of miR-3099 at different time points following peripheral nerve injury. Our results confirmed that increased miR-3099 level induced by peripheral nerve injury can promote the proliferation and migration of Schwann cells. 展开更多
关键词 NERVE REGENERATION peripheral NERVE injury miR-3099 SCIATIC NERVE gene expression Schwann cells PROLIFERATION MIGRATION target genes mechanisms neural REGENERATION
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Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects 预览
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作者 Alessandro Crosio Benedetta Elena Fornasari +5 位作者 Giovanna Gambarotta Stefano Geuna Stefania Raimondo Bruno Battiston Pierluigi Tos Giulia Ronchi 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1079-1084,共6页
Nerve regeneration after delayed nerve repair is often unsuccessful.Indeed,the expression of genes associated with regeneration,including neurotrophic and gliotrophic factors,is drastically reduced in the distal stump... Nerve regeneration after delayed nerve repair is often unsuccessful.Indeed,the expression of genes associated with regeneration,including neurotrophic and gliotrophic factors,is drastically reduced in the distal stump of chronically transected nerves;moreover,Schwann cells undergo atrophy,losing their ability to sustain regeneration.In the present study,to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth,we combined the use of an effective conduit(a chitosan tube)with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers).This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction.Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft,considered the“gold standard”technique for nerve reconstruction.Since hollow tubes not always lead to good results after long defects(>20 mm),we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps,as muscle fibers create a favorable three-dimensional environment and release trophic factors.All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number:864/2016/PR)on September 14,2016. 展开更多
关键词 tubulization Schwann cells SCAFFOLD tissue engineering NERVE reconstruction morphometrical analyses GRASPING test secondary repair MEDIAN NERVE NERVE REGENERATION
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Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats 预览
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作者 Jian-Tao Yang Jin-Tao Fang +3 位作者 Liang Li Gang Chen Ben-Gang Qin Li-Qiang Gu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1932-1940,共9页
Nerve grafting has always been necessary when the contralateral C7 nerve root is transferred to treat brachial plexus injury. Acellular nerve allograft is a promising alternative for the treatment of nerve defects, an... Nerve grafting has always been necessary when the contralateral C7 nerve root is transferred to treat brachial plexus injury. Acellular nerve allograft is a promising alternative for the treatment of nerve defects, and results were improved by grafts laden with differentiated adipose stem cells. However, use of these tissue-engineered nerve grafts has not been reported for the treatment of brachial plexus injury. The aim of the present study was to evaluate the outcome of acellular nerve allografts seeded with differentiated adipose stem cells to improve nerve regeneration in a rat model in which the contralateral C7 nerve was transferred to repair an upper brachial plexus injury. Differentiated adipose stem cells were obtained from Sprague-Dawley rats and transdifferentiated into a Schwann cell-like phenotype. Acellular nerve allografts were prepared from 15-mm bilateral sections of rat sciatic nerves. Rats were randomly divided into three groups: acellular nerve allograft, acellular nerve allograft + differentiated adipose stem cells, and autograft. The upper brachial plexus injury model was established by traction applied away from the intervertebral foramen with micro-hemostat forceps. Acellular nerve allografts with or without seeded cells were used to bridge the gap between the contralateral C7 nerve root and C5–6 nerve. Histological staining, electrophysiology, and neurological function tests were used to evaluate the effect of nerve repair 16 weeks after surgery. Results showed that the onset of discernible functional recovery occurred earlier in the autograft group first, followed by the acellular nerve allograft + differentiated adipose stem cells group, and then the acellular nerve allograft group;moreover, there was a significant difference between autograft and acellular nerve allograft groups. Compared with the acellular nerve allograft group, compound muscle action potential, motor conduction velocity, positivity for neurofilament and S100, diameter of regenerating axons, myelin sheath thickness, 展开更多
关键词 NERVE REGENERATION peripheral NERVE INJURY brachial plexus INJURY CONTRALATERAL C7 NERVE root acellular NERVE adipose stem CELLS Schwann CELLS tissue engineering NERVE NERVE grafting NERVE defect neural REGENERATION
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Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation 预览
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作者 Gong-Hai Han Jiang Peng +4 位作者 Ping Liu Xiao Ding Shuai Wei Sheng Lu Yu Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第8期1343-1351,共9页
In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve sc... In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury. 展开更多
关键词 NERVE REGENERATION PERIPHERAL NERVE injury NERVE conduits DECELLULARIZATION EXTRACELLULAR matrix Schwann cell neural REGENERATION
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Comparative study of microarray and experimental data on Schwann cells in peripheral nerve degeneration and regeneration:big data analysis 预览
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作者 Ulfuara Shefa Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1099-1104,共6页
A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells.Microarray data provi... A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells.Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses.According to microarray data,several genes exhibit increased expression(fold change)but they are weakly expressed in experimental studies(based on morphology,protein and mRNA levels).In contrast,some genes are weakly expressed in microarray data and highly expressed in experimental studies;such genes may represent future target genes in Schwann cell studies.These studies allow us to learn about additional genes that could be used to achieve targeted results from experimental studies.In the current big data study by retrieving more than 5000 scientific articles from PubMed or NCBI,Google Scholar,and Google,1016(up-and downregulated)genes were determined to be related to Schwann cells.However,no experiment was performed in the laboratory;rather,the present study is part of a big data analysis.Our study will contribute to our understanding of Schwann cell biology by aiding in the identification of genes.Based on a comparative analysis of all microarray data,we conclude that the microarray could be a good tool for predicting the expression and intensity of different genes of interest in actual experiments. 展开更多
关键词 Schwann cells big data analysis PERIPHERAL NERVE DEGENERATION PERIPHERAL NERVE REGENERATION MICROARRAY matched GENES promising GENES gene ranking
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MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronallike cells by Schwann cell-conditioned medium 预览
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作者 Zhi-Jian Wei Bao-You Fan +9 位作者 Yang Liu Han Ding Hao-Shuai Tang Da-Yu Pan Jia-Xiao Shi Peng-Yuan Zheng Hong-Yu Shi Heng Wu Ang Li Shi-Qing Feng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第8期1462-1469,共8页
Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and ident... Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and identified differentially expressed microRNAs in bone marrow- derived mesenchymal stem cells induced by Schwann cell-conditioned medium, and explored targets and related pathways involved in their differentiation into neuronal-like cells. Primary bone marrow-derived mesenchymal stem cells were isolated from femoral and tibial bones, while primary Schwann cells were isolated from bilateral saphenous nerves. Bone marrow-derived mesenchymal stem cells were cultured in unconditioned (control group) and Schwann cell-conditioned medium (bone marrow-derived mesenchymal stem cell + Schwann cell group). Neuronal differentiation of bone marrow-derived mesenchymal stem cells induced by Schwann cell-conditioned medium was observed by time-lapse imaging. Upon induction, the morphology of bone marrow-derived mesencaymal stem cells changed into a neural shape with neurites. Results of quantitative reverse transcription-polymerase chain reaction revealed that nestin mRNA expression was upregulated from 1 to 3 days and downregulated from 3 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. Compared with the control group, microtubule-associated protein 2 mRNA expression gradually increased from 1 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. After 7 days of induction, microRNA analysis iden:ified 83 significantly differentially expressed microRNAs between the two groups. Gene Ontology analysis indicated enrichment of microRNA target genes for neuronal projection development, regulation of axonogenesis, and positive regulation of cell proliferation. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that Hippo, Wnt, transforming growth factor-beta, and Hedgehog signaling pathv/ays were potentially associated with neural differentiation of b 展开更多
关键词 nerve REGENERATION MICRORNA analysis bone marrow-derived mesenchymal stem cells: Schwann CELLS neuronal-like CELLS neuronal differentiation Gene Ontology analysis Hippo SIGNALING PATHWAY Wnt SIGNALING PATHWAY transforming growth FACTOR-BETA SIGNALING PATHWAY Hedgehog SIGNALING PATHWAY neural REGENERATION
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Electrospun polypyrrole-coated polycaprolactone nanoyarn nerve guidance conduits for nerve tissue engineering
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作者 Xin PAN Binbin SUN Xiumei MO 《材料科学前沿:英文版》 SCIE CSCD 2018年第4期438-446,共9页
Nerve guidance conduits (NGCs) can provide suitable microenvironment for nerve repair and promote the proliferation and migration of Schwann cells (SCs). Thus, we developed nerve guidance conduits (NGCs) with polypyrr... Nerve guidance conduits (NGCs) can provide suitable microenvironment for nerve repair and promote the proliferation and migration of Schwann cells (SCs). Thus, we developed nerve guidance conduits (NGCs) with polypyrrole-coated poly-caprolactone nanoyarns (PPy-PCL-NYs) as fillers in this study. PCL-NYs with the oriented structure were prepared with a double-needle electrospinning system and then PPy was coated on PCL-NYs via the in situ chemical polymerization. Subsequently, PCL nanofibers were collected around nanoyarns by the conventional electrospinning process as the outer layer to obtain PPy-PCL-NY nerve guidance conduits (PPy-PCL- NY NGCs). PPy-PCL-NYs were analyzed by SEM, FTIR and XPS. Results showed that PPy was homogeneously and uniformly deposited on the surface of PCL-NY. Strain-stress curves and the Young’s modulus of PPy-PCL-NYs were investigated compared with those of non-coated PCL-NYs. Studies on biocompatibility with SCs indicated that PPy-PCL-NY NGCs were more conducive to the proliferation of SCs than PCL-NY NGCs. In summary, PPy-PCL-NY NGCs show the promising potential for nerve tissue engineering repair and regeneration. 展开更多
关键词 electrospinning Schwann cell (SC) POLYPYRROLE (PPy) POLYCAPROLACTONE nanoyarn (PCL-NY) NERVE GUIDANCE conduit (NGC)
糖尿病周围神经修复再生中雪旺细胞的作用及中药对其影响的研究 被引量:7
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作者 刘伟 梁晓春 《中国中西医结合杂志》 CAS CSCD 北大核心 2016年第8期1021-1024,共4页
糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病常见的慢性并发症之一,可累及感觉、运动及自主神经。周围神经受损后导致神经变性、坏死及功能丧失严重影响患者的生活质量,如何促进神经纤维的修复再生是近年来研究... 糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病常见的慢性并发症之一,可累及感觉、运动及自主神经。周围神经受损后导致神经变性、坏死及功能丧失严重影响患者的生活质量,如何促进神经纤维的修复再生是近年来研究的热点。雪旺细胞(Schwann cells,SCs)是形成周围神经髓鞘的主要胶质细胞[1],其在周围神经修复再生中的作用引起学者的广泛关注。高糖状态易造成周围神经轴突萎缩、 展开更多
关键词 修复再生 雪旺细胞 糖尿病大鼠 神经轴突 神经髓鞘 大鼠坐骨神经 Schwann 神经变性 高糖状态 NEUROPATHY
骨髓间充质干细胞向雪旺细胞诱导分化方法的研究进展
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作者 李爽 马信龙 +1 位作者 马剑雄 孙晓雷 《国际生物医学工程杂志》 CAS 北大核心 2011年第4期227-231,共5页
细胞移植技术治疗周围神经损伤已成为新兴的组织工程学研究热点。骨髓间充质干细胞(BMSCs),由于其具有扩增快、便于分离提纯、可以体外诱导分化成为雪旺细胞(sc)的特性,有可能成为雪旺细胞的有效替代品和组织工程化神经的新型种... 细胞移植技术治疗周围神经损伤已成为新兴的组织工程学研究热点。骨髓间充质干细胞(BMSCs),由于其具有扩增快、便于分离提纯、可以体外诱导分化成为雪旺细胞(sc)的特性,有可能成为雪旺细胞的有效替代品和组织工程化神经的新型种子细胞。就种子细胞雪旺细胞和骨髓间充质干细胞的生理功能、生物学特性、体外诱导骨髓问充质干细胞生成雪旺细胞的方法以及研究前景作一综述。 展开更多
关键词 雪旺细胞 骨髓间充质干细胞 诱导分化 组织工程
试析施莱登与施旺“细胞学说”的理论缺陷 预览
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作者 孙毅霖 《上海交通大学学报:哲学社会科学版》 2003年第6期 48-52,共5页
细胞学说是19世纪自然科学的三大发现之一.该学说在创立之初存在着被很多人忽视的先天性缺陷,即施莱登与施旺把动植物的基本单位--细胞的生成,看作是与无机物的结晶完全相同的物理过程.这种先天性的缺陷,主要是显微镜技术问题以及当时... 细胞学说是19世纪自然科学的三大发现之一.该学说在创立之初存在着被很多人忽视的先天性缺陷,即施莱登与施旺把动植物的基本单位--细胞的生成,看作是与无机物的结晶完全相同的物理过程.这种先天性的缺陷,主要是显微镜技术问题以及当时普遍流行的生命自然发生论的影响造成的. 展开更多
关键词 施莱登 施旺 “细胞学说” 显微镜技术
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海外书刊介绍 预览
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《音乐爱好者》 2001年第3期 5-7,共3页
今年的维也纳新年音乐会邀请哈农库特指挥使观众对这位巴洛克音乐权威阐释者有了新的认识,众所周知,哈农库特本人不仅是指挥家还是音乐学者,60年代前后哈农库特曾经发表过大量论文讨论巴洛克音乐。现在,哈农库特将这些文章汇编为《... 今年的维也纳新年音乐会邀请哈农库特指挥使观众对这位巴洛克音乐权威阐释者有了新的认识,众所周知,哈农库特本人不仅是指挥家还是音乐学者,60年代前后哈农库特曾经发表过大量论文讨论巴洛克音乐。现在,哈农库特将这些文章汇编为《今日巴洛克音乐》一书,借以阐述自己对音乐史、巴洛克音乐演释等诸方面问题的观点。一位指挥家如此系统地提出自己的音乐学观点是少见的,读者可以由此探寻哈农库特指挥艺术的堂奥。哈农库特是一位音乐至上的唯美主义 展开更多
关键词 《今日巴洛克音乐》 西莉亚·芭托莉 《梅纽因——世纪小提琴》 《音乐之友》 Schwann Opus》 《里纳尔多》 《阿尔米达》
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INTRACEREBRAL CO-GRAFTING OF SCHW ANN’S CELLS AND FETAL ADRENAL MEDULLA IN THE TREATMENT OF PARKINSON’S DISEASE
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作者 张瓦城 丁育基 +3 位作者 曹家康 杜建新 张国风 刘玉军 《中华医学杂志:英文版》 SCIE CAS CSCD 1994年第8期25-30,共6页
Intracerebral co-grafting of Schwann’s cells and human fetal adrenal medullary tissue was performed in 10 patients with Parkinson’s disease. One to six months after grafting, symptoms were improved significantly fo... Intracerebral co-grafting of Schwann’s cells and human fetal adrenal medullary tissue was performed in 10 patients with Parkinson’s disease. One to six months after grafting, symptoms were improved significantly for 1 to 3 grade. Among them, 2 patients resumed nearly normal daily activities. Long-term follow-up showed that the symptoms were not improved satisfactorily in some patients. It is considered that careful selection of patients, administration of amantadine, and co-grafting of Schwann’s cells which prompts the survival of chromaffin cells are essential to better results. 展开更多
关键词 GRAFTING Schwann MEDULLARY administration FETAL careful adrenal VOMITING phenome rigidity
细胞大小的制约因子 预览
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作者 周国飞 《浙江海洋学院学报:人文科学版》 1994年第3期64-68,共5页
十九世纪三十年代末,德国植物学家施莱登(M.J.Schleiden)和动物学家施旺(T.Schwann)提出细胞学说,认为细胞是有机体,动、植物都是这些有机体的集合物,它们按照一定的规则排列在动、植物体内。从此,对生命的研究进入了细胞水平,并逐步发... 十九世纪三十年代末,德国植物学家施莱登(M.J.Schleiden)和动物学家施旺(T.Schwann)提出细胞学说,认为细胞是有机体,动、植物都是这些有机体的集合物,它们按照一定的规则排列在动、植物体内。从此,对生命的研究进入了细胞水平,并逐步发现,生物的细胞大小总是限定在某一狭窄的范围内(表1)。 展开更多
关键词 制约因子 施旺 细胞分化 施莱登 细胞学说 Schwann 伸长区 动物学家 等基因 十九世纪
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口腔颌面及颈部神经鞘瘤 预览
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作者 王永海 周树夏 《口腔颌面外科杂志》 CAS 1993年第2期116-117,共2页
神经鞘瘤是1910年Verocay首先报告它来自神经鞘膜的Schwann氏细胞,故亦称为雪旺氏瘤。一般认为此肿瘤在颅内多发于听神经或小脑桥,在末梢神经它可以发生在任何部位。有人对软组织良性肿瘤的统计分析认为神经鞘膜瘤的发生率仅次于血管... 神经鞘瘤是1910年Verocay首先报告它来自神经鞘膜的Schwann氏细胞,故亦称为雪旺氏瘤。一般认为此肿瘤在颅内多发于听神经或小脑桥,在末梢神经它可以发生在任何部位。有人对软组织良性肿瘤的统计分析认为神经鞘膜瘤的发生率仅次于血管瘤、脂肪瘤。发生在口腔颌面颈部的神经鞘瘤李树玲、张船等已有报告,但数量不多。我科自1975年8月以来共收治96例,现总结分析如下。 展开更多
关键词 颈部神经鞘瘤 神经鞘膜瘤 血管瘤 面颈部 Schwann 神经纤维瘤病 鞘膜 恶性神经鞘瘤 良性神经鞘瘤 颈动脉体瘤
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头颈部外周神经肿瘤与恶性血管外皮细胞瘤的临床病理观察 预览
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作者 王文崔 陈必胜 +1 位作者 周洁 陈泳莲 《口腔颌面外科杂志》 CAS 1992年第3期47-49,65共4页
常见的外周神经肿瘤主要为神经鞘瘤(neurolemoma)又称Schwann氏瘤与神经纤维瘤(neurofibroma)或神经纤维瘤病(neurofibromatosis)又称von Rechlinghausen’s病。这类肿瘤好发于头颈部,大多为良性,预后良好,早期手术,多能得到良好的效... 常见的外周神经肿瘤主要为神经鞘瘤(neurolemoma)又称Schwann氏瘤与神经纤维瘤(neurofibroma)或神经纤维瘤病(neurofibromatosis)又称von Rechlinghausen’s病。这类肿瘤好发于头颈部,大多为良性,预后良好,早期手术,多能得到良好的效果,但也有少数病例为恶性或恶变为肉瘤,尚有极少 展开更多
关键词 血管外皮细胞瘤 外周神经 神经纤维瘤病 病理观察 神经鞘瘤 肉瘤变 Schwann 瘤细胞 神经纤维肉瘤 预后良好
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胃蛋白酶的固定化及其在亲和层析法提纯Pepstatin上的应用 预览
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作者 张寅 吉鑫松 《中国生化药物杂志》 CAS CSCD 1989年第4期37-43,共7页
胃蛋白酶(pepsin)是人们较早认识(Spallanzani 1783)并命名(Schwann,1825)的单纯酶,在脲酶以后第二个得到了该酶的结晶。胃蛋白酶是胃液中的主要酶,具有很低的等电
关键词 PEPSTATIN 亲和层析法 固相酶 活力单位 单纯酶 Schwann 柠檬酸缓冲液 游离酶 洗脱条件 湿重
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