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Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties 认领
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作者 Ivonne Rosales Laura Salazar +4 位作者 Daniel Luna Alicia Negrón Igor Bdikin Brian J. Rodriguez Alejandro Heredia 《美国分子生物学期刊(英文)》 2021年第1期1-14,共14页
Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process c... Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases;2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field. 展开更多
关键词 AMYLOID Neurodegenerative Disorders SELF-ASSEMBLY PIEZOELECTRICITY
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基于表面张力的复合微组装技术研究 认领
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作者 常博 徐彬 +2 位作者 王彬开 李席 王敏 《陕西科技大学学报》 CAS 2021年第1期153-158,共6页
微组装在微纳机电系统集成、柔性可拉伸电路及微型传感器制造等领域占据重要地位,然而,在微纳尺度下,由于尺度效应,重力不再起决定性作用,与面积相关的力占据主导地位,导致微器件难以释放及精准定位.提出一种结合机器人微组装与表面张... 微组装在微纳机电系统集成、柔性可拉伸电路及微型传感器制造等领域占据重要地位,然而,在微纳尺度下,由于尺度效应,重力不再起决定性作用,与面积相关的力占据主导地位,导致微器件难以释放及精准定位.提出一种结合机器人微组装与表面张力自组装技术的复合微组装方法,采用机器人微组装技术完成芯片的快速初次定位,利用表面张力自组装技术实现微芯片与基底之间的高精度自对齐.建立了表面张力自组装的仿真模型,研究了芯片与基底之间的错动量、液滴体积对液桥表面自由能和自组装恢复力的影响,结果表明液桥表面自由能及自组装恢复力随错动量和液滴体积的增加而变大.通过实验研究了液滴体积、芯片与基底之间的错动量对自组装成功率和自组装时间的影响,结果表明当错动量在50~500μm范围内,液滴体积在30~110 nL范围内时,自组装成功率可达100%.该方法结合了高速机器人微组装技术以及高精度表面张力自组装技术的优势,为同时实现高效、高精度的微机电系统集成及柔性电路制造等应用领域提供了新方法. 展开更多
关键词 微组装 自对齐 自组装 表面张力 液桥
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文章速递Supramolecular nano drug delivery systems mediated via host-guest chemistry of cucurbit[n]uril(n=6 and 7) 认领
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作者 Shengke Li Yan Gao +2 位作者 Yuanfu Ding Anni Xu Huaping Tan 《中国化学快报:英文版》 SCIE CAS CSCD 2021年第1期313-318,共6页
As a novel family of macrocyclic molecules,cucurbit[n]urils(CB[n]s) have emerged as promising building blocks of supramolecular nano drug delivery systems(SNDDS) in recent years.Direct encapsulation of amphiphilic gue... As a novel family of macrocyclic molecules,cucurbit[n]urils(CB[n]s) have emerged as promising building blocks of supramolecular nano drug delivery systems(SNDDS) in recent years.Direct encapsulation of amphiphilic guests by CB[6] and CB[7] can modulate their amphiphilicity,resulting in formation of supramolecular amphiphiles that self-assemble into supramolecular nanoparticles for drug delivery.Additionally,CB[n]'s host-guest chemistry on the surface of mesoporous nanoparticles makes CB[n] an ideal blocking agent to control drug release from delivery vehicles.These SNDDS possess intrinsic stimuli responsiveness towards external guest or host,which can further incorporate re s ponsiveness to a variety of other stimuli including pH,thermal,redox,photo and enzyme,to realize multiple stimuli-responsive drug release.Moreover,the recent breakthrough in direct functionalization of CB[n]s has provided a feasible method for preparing superior CB[6] and CB[7] derivatives that can be employed to build multifunctional SNDDS with unoccupied macrocycles located on surface,which could be decorated with various functional "tags" through host-guest chemistry.In this review,we summarized the recent progress of CB[6] and CB[7] based SNDDS through formation of supramolecular amphiphiles,supramolecular nanovalves as well as supramolecularly tailorable surface,which we hope to further promote the development of CB[n]s family as building blocks for advanced SNDDS. 展开更多
关键词 Cucurbit[n]uril Host-guest chemistry Self-assembly Nano Drug delivery Stimuli-responsive
文章速递Coordination-driven self-assembly of palladium(Ⅱ)-based metallacalixarenes as anion receptors using flexible pyridine-bridged diimidazole ligands 认领
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作者 Wutong Du Jin Tong +2 位作者 Wei Deng Mingxue Wang Shuyan Yu 《中国化学快报:英文版》 SCIE CAS CSCD 2021年第1期485-488,共4页
Two types of palladiu m(Ⅱ)-based metallacalixarenes [ML]~(2+) and [ML_2]~(2+) have been synthesized through coordination-driven self-assembly from a series of flexible pyridine-bridged diimidazole ligands [2,6-bis((1... Two types of palladiu m(Ⅱ)-based metallacalixarenes [ML]~(2+) and [ML_2]~(2+) have been synthesized through coordination-driven self-assembly from a series of flexible pyridine-bridged diimidazole ligands [2,6-bis((1 H-imidazol-1-yl)methyl) pyridine(L~1),2,6-bis((1 H-benzo[d]imidazol-1-yl)methyl)pyridine(L~2),2,6-bis((1 H-naphtho[2,3-d]imidazol-1-yl)methyl)pyridine(L~3)],with palladium(II)-based building blocks[Pd(BF_4)_2(M~1-BF_4) and(tmeda)Pd(NO_3)_2(M~2-NO_3)(tmeda=N,N,N',N'-tetramethyl-ethylenediamine)].All complexes were characterized by NMR spectroscopy(~1 H NMR and ~(13)C NMR),mass spectrometry(CSIMS,ESI-HRMS) and elemental analysis.The single crystal X-ray diffraction analysis of [M~1 L~2_2](NO_3)_2,[M~1 L~3_2](NO_3)_2,[M~1 L~3_2](PF_6)_2 and [M~2 L~3](NO_3)_2 further confirmed the uniquely single bowl-shape and double bowl-shape structures.The anion binding properties within the metallacalixarenes as receptors were also investigated by NMR titration experiments in DMSO. 展开更多
关键词 Self-assembly Diimidazole ligand Metallacalixarenes Anion receptors
文章速递Layer-by-layer stacked graphene nanocoatings by Marangoni self-assembly for corrosion protection of stainless steel 认领
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作者 Chen Ye Yangguang Zhu +12 位作者 Hongyan Sun Feiyue Chen Huifang Sun Wen Dai Qiuping Wei Li Fu Aimin Yu Shiyu Du Minghui Yang Liang-Feng Huang Jinhong Yu Nan Jiang Cheng-Te Lin 《中国化学快报:英文版》 SCIE CAS CSCD 2021年第1期501-505,共5页
Graphene nanosheets are widely used in anti-corrosion polymeric coating as filler,owing to the excellent electrochemical inertness and barrier property.However,as the arrangement of graphene nanosheets is difficult to... Graphene nanosheets are widely used in anti-corrosion polymeric coating as filler,owing to the excellent electrochemical inertness and barrier property.However,as the arrangement of graphene nanosheets is difficult to form a perfect layered structure,polymeric coating with graphene nanosheets usually needs micron-scale thickness to ensure the enhancement of corrosion protection.In this work,layer-by-layer stacked graphene nanocoatings were fabricated on stainless steel by self-assembly based on Marangoni effect.The anti-corrosion property of graphene coatings were studied through Tafel polarization curves,electrochemical impedance spectroscopy and accelerated corrosion test with extra applied voltage.The self corrosion current density of optimized three-layered graphene coated sample was one quarter of that of bare stainless steel.And the self corrosion potential of optimized sample is increased to-0.045 V.According to the results,graphene nanocoatings composed of layered nanosheets exhibits good anticorrosion property.Besides,the self-assembly method provide a promising approach to make layeredstructure coating for other researches about 2 D material nanosheets. 展开更多
关键词 Self-assembly Graphene nanosheets Layer-by-layer stacking Electrochemical corrosion Anti-corrosion coating
文章速递分子共晶:有机光电子学领域的新星 认领
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作者 朱伟钢 张小涛 胡文平 《科学通报:英文版》 SCIE EI CSCD 2021年第5期512-520,M0004,共10页
从分子共晶出发,综述了晶体的形核生长规律和形貌精准控制,阐述了如何实现具有不同形貌、不同给受体比例共晶的大规模选择性制备,为今后可控制备其他共晶材料提供了有力借鉴.结合介绍本课题组自主发展的微纳米单晶场效应晶体管、光响应... 从分子共晶出发,综述了晶体的形核生长规律和形貌精准控制,阐述了如何实现具有不同形貌、不同给受体比例共晶的大规模选择性制备,为今后可控制备其他共晶材料提供了有力借鉴.结合介绍本课题组自主发展的微纳米单晶场效应晶体管、光响应电子器件、光波导和光子学逻辑运算、非线性光学响应等测试方法及其原理,对分子共晶的新型电子学和光子学性质进行了梳理归纳,总结出了一些具有普适性的"分子结构-分子堆积-光电性质"构效关系规律,认为分子堆积对电荷转移及晶体最终光电磁性质起到决定性作用.设计合成具有三维立体π共轭体系的分子材料、发展三元及多元共晶、大面积图案化制备共晶及其异质结构将是最重要的研究突破口,为分子共晶在有机光电子科学与工程、新材料和化学工程等领域的进一步发展指明了方向. 展开更多
关键词 场效应晶体管 光子学 化学工程 三维立体 逻辑运算 分子材料 异质结构 电荷转移
文章速递自组装三维光子结构的研究进展及其应用 认领
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作者 方文兵 胡建臣 张克勤 《现代化工》 CAS CSCD 北大核心 2021年第1期38-43,48,共7页
概述了三维光子结构的分类、生色机理、制备方法和应用,讨论了自组装光子结构产生结构色的虹彩效应、低色彩饱和度以及结构不稳定的问题,分析了三维光子结构的发展方向。
关键词 结构色 自组装 三维光子结构 虹彩效应 色彩饱和度
文章速递Adaptive Self-Assembly and Induced-Fit Interconversions between Molecular Borromean Rings,Russian Dolls and Ring-in-Ring Complexes 认领
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作者 Ye Lu Dong Liu +2 位作者 Zheng Cui Yue-Jian Lin Guo-Xin Jin 《中国化学:英文版》 SCIE CAS CSCD 2021年第2期360-366,共7页
Herein,we report an artificially assembled interlocked system that features adaptive self-assembly and induced-fit transformation properties in the presence of appropriate guest molecules.By careful choice of solvent ... Herein,we report an artificially assembled interlocked system that features adaptive self-assembly and induced-fit transformation properties in the presence of appropriate guest molecules.By careful choice of solvent and guests,a molecular Borromean rings complex based on organometallic half-sandwich units could be transformed in a stepwise manner to a ring-in-ring complex and a monomeric rectangle,leading to a conversion cycle between these structures.This adaptive self-assembly method was further applied to the construction of a Russian dolls complex,forming another conversion cycle composed of a molecular Borromean rings complex,a Russian dolls complex and a monomeric rectangle.A comprehensive map showing all of the structural transformations between these metallarectangles and interlocked species is drawn up,representing a recoverable and recyclable transformation mechanism. 展开更多
关键词 Supramolecular chemistry Catenanes Self-assembly Borromean rings Ring-in-ring complex
文章速递共价有机框架和荧光分子的一体化自组装对神经毒模拟物的超灵敏检测 认领
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作者 巩彦君 郭永先 +7 位作者 邱长坤 张宗泽 仉凤华 魏延泽 王舒平 车延科 魏璟婧 杨志杰 《中国科学:材料科学(英文版)》 SCIE EI CAS CSCD 2021年第5期1189-1196,共8页
荧光分子通过非共价键作用载入到多孔矩阵中能够拓展其应用范围.本文报道了利用乳液限域的方法将带有苯并噻二唑和9,9-二己基芴基团的荧光分子1和共价有机框架(Covalent Organic Frameworks, COFs)一体化自组装,使得分子1通过CH-π作用... 荧光分子通过非共价键作用载入到多孔矩阵中能够拓展其应用范围.本文报道了利用乳液限域的方法将带有苯并噻二唑和9,9-二己基芴基团的荧光分子1和共价有机框架(Covalent Organic Frameworks, COFs)一体化自组装,使得分子1通过CH-π作用固定在共价有机框架的骨架之上.因此这会极大地抑制荧光分子之间的π-π作用,使其表现出荧光分子单体的光学性质.更有意思的是,共价有机框架和神经毒剂模拟物(DCP)的特殊的作用,使得一体化自组装的复合物能够实现对神经毒剂模拟物高灵敏度的检测(检测限为40 ppb).而且,当前的一体化组装策略能够被拓展用于装载多种不同发射波长的荧光分子来实现白光.我们的结果提供了一种利用荧光探针分子和共价有机框架综合自组装来制备高发光效率多孔材料的新方法. 展开更多
关键词 荧光探针分子 非共价键作用 荧光分子 神经毒剂 模拟物 苯并噻二唑 共价有机框架 高发光效率
萘羧酸膦酸铜配合物的合成与表征 认领
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作者 卜康 吉玉如 +2 位作者 王楠 徐阳 王宣 《人工晶体学报》 EI CAS 北大核心 2021年第1期102-105,112,共5页
本文以萘羧酸膦酸配体(5-pncH 3=(5-phosphono-1-naphthalenecarboxylic acid)和高氯酸铜为原料,在水热条件下自组装得到了一维配合物Cu 0.5(5-pncH 2)(H2O)1.5(1)。采用单晶衍射(X-Ray)、元素分析(EA)、红外光谱(FT-IR)、粉末衍射(Powd... 本文以萘羧酸膦酸配体(5-pncH 3=(5-phosphono-1-naphthalenecarboxylic acid)和高氯酸铜为原料,在水热条件下自组装得到了一维配合物Cu 0.5(5-pncH 2)(H2O)1.5(1)。采用单晶衍射(X-Ray)、元素分析(EA)、红外光谱(FT-IR)、粉末衍射(Powder X-Ray)、热重分析(TG-DTG)对配合物进行晶体结构和热稳定性表征。晶体结构分析表明:该配合物结晶于正交晶系,Pbcm空间群,a=0.66788(2)nm,b=0.88414(2)nm,c=4.17403(9)nm。配合物1的晶体结构中相邻的金属Cu^Ⅱ离子由配位水分子连接成一维锯齿状无机链。这些相邻的无机链通过萘羧酸膦酸配体上未配位的双重羧基氢键连接成层状结构。热稳定性研究表明,配合物呈现出逐级分解过程,在350℃以下能够保持配合物骨架结构的稳定性。 展开更多
关键词 铜配合物 自组装 晶体结构 热稳定性
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Water-soluble hollow nanocrystals from self-assembly of AIEEactive Pt(II)metallomesogens 认领
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作者 Cristian Cuerva Javier Fernandez-Lodeiro +2 位作者 Mercedes Cano Jose Luis Capelo-Martinez Carlos Lodeiro 《纳米研究:英文版》 SCIE EI CAS 2021年第1期245-254,共10页
Luminescent hollow micro-and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II)metal... Luminescent hollow micro-and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II)metallomesogens decorated with four terminal alkyl chains.Oil-in-water droplets have been used to confine the Pt(II)compounds and drive them to be self-assembled via intermolecular Pt…Pt interactions into spherical aggregates of about 200 or 50 nm.Evaporation of the oil phase generates highly-stable aqueous dispersions of nanocrystals that emit a bright orange light as a result of the existence of^(3)MMLCT excited states.Different methods and conditions have been tested for studying the effect of several parameters such as the temperature and the stirring speed in the final particle size and in the polydispersity index.Moreover,the micro-and nanocrystals are able to entrap hydrophobic drugs between the alkyl chains of the compounds,forming stable dispersions of drug-loaded capsules in water.The droplet method is applied in the area of metallomesogens for the first time to synthesize self-assembled Pt(II)nanocapsules,which opens a new field of study that could allow the use of these liquid crystal materials in biomedical applications. 展开更多
关键词 R(II)metallomesogens SELF-ASSEMBLY luminescent nanomaterials droplets NANOCAPSULES
具有附加值的表面活性剂的现状及研究进展(续完) 认领
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作者 肖进新 S.Polarz +2 位作者 M.Kunkel A.Donner M.Schlotter 《日用化学品科学》 CAS 2021年第2期8-13,共6页
4通过物理触发来影响表面活性剂的自组装高性能表面活性剂能够对多种化学触发因素产生反应。这些方法的缺点是刺激响应过程相对缓慢,而且整个体系的组成可能会改变。纯物理触发的优点是——完全可逆性的机率更高,因为体系的组成保持不... 4通过物理触发来影响表面活性剂的自组装高性能表面活性剂能够对多种化学触发因素产生反应。这些方法的缺点是刺激响应过程相对缓慢,而且整个体系的组成可能会改变。纯物理触发的优点是——完全可逆性的机率更高,因为体系的组成保持不变因而它们可以更快地应用。 展开更多
关键词 触发因素 刺激响应 表面活性剂 可逆性 附加值 物理 自组装 研究进展
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冷冻电子显微镜观察人釉原蛋白的自组装 认领
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作者 赖婷婷 陈亮 +1 位作者 张川 田鲲 《实用口腔医学杂志》 CAS 北大核心 2021年第1期114-118,共5页
目的:采用冷冻电子显微镜(cryo TEM)体外观察人釉原蛋白的自组装过程,分析自组装各阶段蛋白的聚集状态及细微结构。方法:提取青少年下颌第三磨牙牙胚细胞总RNA,用RT-PCR获得人釉原蛋白基因全长,再与pMD19-T载体构建重组质粒,转入宿主菌E... 目的:采用冷冻电子显微镜(cryo TEM)体外观察人釉原蛋白的自组装过程,分析自组装各阶段蛋白的聚集状态及细微结构。方法:提取青少年下颌第三磨牙牙胚细胞总RNA,用RT-PCR获得人釉原蛋白基因全长,再与pMD19-T载体构建重组质粒,转入宿主菌E.coli Top10中诱导表达并纯化。冷冻电子显微镜观察pH值从3.5跃升至8.0时釉原蛋白发生自组装的聚合状态。结果:当pH值为8.0时在1~20 min内观察到釉原蛋白由低聚体逐步组装成多聚体、纳米球及纳米链等结构。结论:在适宜条件下,人釉原蛋白能分级组装成纳米球。 展开更多
关键词 冷冻电子显微镜 釉原蛋白 自组装
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基于透明质酸生物活性自组装胶体粒子制备及乳化性能 认领
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作者 张翠歌 胡良 +2 位作者 孙元峰 林浩东 罗宇浩 《化学研究与应用》 CAS 北大核心 2021年第2期309-316,共8页
用透明质酸(HA)和溶菌酶(Lys)静电自组装制备胶体粒子。研究了溶菌酶和透明质酸的质量比(WR)对胶体粒子性质的影响,得到最佳质量比下的胶体粒子。用纳米粒度仪和透射电镜对胶体粒子的尺寸和形貌进行表征。结果显示,形成的胶体粒子为球... 用透明质酸(HA)和溶菌酶(Lys)静电自组装制备胶体粒子。研究了溶菌酶和透明质酸的质量比(WR)对胶体粒子性质的影响,得到最佳质量比下的胶体粒子。用纳米粒度仪和透射电镜对胶体粒子的尺寸和形貌进行表征。结果显示,形成的胶体粒子为球形结构,粒径约250 nm。此胶体粒子可二次组装在油水界面稳定水包油型类凝胶Pickering乳液。详细研究了pH和盐浓度对胶体粒子性质和乳化性能的影响。结果表明,随着pH增加,胶体粒子粒径先减小后增加;乳液滴粒径逐渐减小,乳化性能逐渐增加。随着盐浓度增加,胶体粒子和乳液滴粒径先降低后增加,乳化性能先增加后降低。进一步研究了pH和盐浓度对乳液中溶菌酶活性的影响。研究表明,制备的乳液均保留了一定的活性,在食品、医药和化妆品领域具有潜在的应用。 展开更多
关键词 自组装 胶体粒子 透明质酸 溶菌酶 酶活
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Phz-H2ca铁电共晶的形貌控制及其各向异性拉曼光谱 认领
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作者 朱伟钢 王云丽 +6 位作者 黄程程 朱凌云 甄永刚 董焕丽 魏志祥 郭栋 胡文平 《中国科学:材料科学(英文版)》 SCIE EI 2021年第1期169-178,共10页
本文首次报道了Phz-H2ca铁电共晶的一种线状形貌,并通过原子力显微镜、透射电子显微镜、X射线衍射、紫外可见吸收光谱、差示扫描量热法和固体核磁等实验手段证实.共晶成核生长实验和Materials Studio软件模拟研究发现,(020)面具有最大... 本文首次报道了Phz-H2ca铁电共晶的一种线状形貌,并通过原子力显微镜、透射电子显微镜、X射线衍射、紫外可见吸收光谱、差示扫描量热法和固体核磁等实验手段证实.共晶成核生长实验和Materials Studio软件模拟研究发现,(020)面具有最大的结合能,在较低前驱体浓度下晶核沿[010]方向组装形成动力学稳定的线状形貌,(002)面具有最小的表面能和最大生长势垒,即使在超饱和前驱体浓度下也只有(200)和(020)等晶面的生长势垒被突破,使晶核沿[100]和[010]两个方向生长为热力学稳定的六边形片状形貌.微区拉曼光谱实验研究表明,两种Phz-H2ca共晶的拉曼峰具有截然不同的各向异性响应性,归因于其不同的分子排布取向.该研究工作实现了对分子共晶的控制制备,阐明了其中的结构功能关系,为共晶功能材料的进一步大规模应用提供了有力借鉴. 展开更多
关键词 前驱体浓度 形貌控制 差示扫描量热法 紫外可见吸收光谱 原子力显微镜 热力学稳定 各向异性 拉曼光谱
Lateral epitaxial growth of two-dimensional heterostructure linked by gold adatoms 认领
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作者 Nan Si Tao Shen +5 位作者 Xinyi Liu Dechun Zhou Qingmin Ji Wei Liu Shuang Li Tianchao Niu 《纳米研究:英文版》 SCIE EI CAS 2021年第3期887-892,共6页
Lateral two-dimensional(2D)heterostructures have great potential for device engineering at the atomistic scale.Their production is hindered by difficulties in obtaining atomically sharp interface free from intermixtur... Lateral two-dimensional(2D)heterostructures have great potential for device engineering at the atomistic scale.Their production is hindered by difficulties in obtaining atomically sharp interface free from intermixture.Here we report the continuous construction of a lateral heterostructure using blue phosphorene and tetrafluoro-tetracyanoquinodimethane(F_(4)TCNQ)as the building blocks.The lateral heterostructure is achieved by linking the semiconducting F_(4)TCNQ-Au metal organic framework and the metallic blue phosphorene-Au network via Au adatoms.The structural and electronic properties of the heterostructure have been investigated by means of scanning tunneling microscopy and spectroscopy(STM/S),complemented by density functional theory(DFT)calculations,demonstrating a structurally and electrically abrupt interface.Our approach offers the possibility of high flexibility and control that can be extended to other metal-organic species and 2D materials,establishing a foundation for the development of atomically thin in-plane superlattice and devices. 展开更多
关键词 phosphorene SELF-ASSEMBLY scanning tunneling microscopy two-dimensional materials density functional theory
Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines 认领
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作者 Fangyuan Li&Daishun Ling Yang Du +6 位作者 Zheng Chen Ji Young Lee Peihua Lin Fan Xia Yunan Guan Fangyuan Li Daishun Ling 《中国科学:化学英文版》 SCIE EI CAS 2021年第2期204-217,共14页
Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized medicine.The integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedi... Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized medicine.The integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical research.Mesoporous silica nanoparticles(MSN)with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic nanomedicines.The rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each nanocomponent.In this review,the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are summarized.We categorize MSN-based nanomedicines by their unique heterostructures,including core-shell,yolk-shell,core-satellite,heterodimer and core-shell-satellite structures,and discuss the controlled assembly approaches as well as the intriguing applications for disease theranostics.Finally,a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted. 展开更多
关键词 self-assembly THERANOSTICS HETEROSTRUCTURE mesoporous silica NANOMEDICINES
3D confined self-assembling of QD within super-engineering block copolymers as biocompatible superparticles enabling stimulus responsive solid state fluorescence 认领
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作者 Xiaohong He Kun Jia +2 位作者 Robert Marks Yiguo Hu Xiaobo Liu 《纳米研究:英文版》 SCIE EI CAS 2021年第1期285-294,共10页
Eliminating colloidal toxicity and enabling its intrinsic fluorescence in aggressive environmental conditions are the key challenges for commercializing hydrophobic cadmium based quantum dots(QD).Polyarylene ether nit... Eliminating colloidal toxicity and enabling its intrinsic fluorescence in aggressive environmental conditions are the key challenges for commercializing hydrophobic cadmium based quantum dots(QD).Polyarylene ether nitriles(PEN)are an example of super-engineering thermoplastics that possess a unique combination of thermal stability,intrinsic fluorescence,biocompatibility and distinct emulsion self-assembly feature.Herein,the co-self-assembly of amphiphilic PEN with hydrophobic CdSe@ZnS QD,confined in the three-dimensional(3D)oil-in-water emulsion droplets,has been explored tofabricate fluorescent microparticles(FMP).It was found that these FMP demonstrated good biocompatibility(cell viability above 90%),while exhibiting a fluorescence emission in aqueous solution that was retained(intensity retention ratio above 80%)within the whole pH range of 1-14,as well as,after being subjected to autoclaving at 120℃for 1 h.Interestingly,it was discovered that introduction of calcium ions in the emulsion self-assembly contributed to in-situ generation of phase changing nanoplates inside the FMP,which led to the photo-thermal modulated solid state fluorescence from drop-casted FMP film.Thanks to their versatile fluorescence,these FMP colloids were exploited as fluorescent probes for macrophages imaging,while micro-patterns with reversible changing of emission color were induced via thermal treatment and direct laser lithography. 展开更多
关键词 three-dimensional(3D)confinement self-assembly quantum dots amphiphilic polyarylene ether nitrile stimulus responsive fluorescence
聚苯乙烯-聚丁二烯嵌段共聚物在选择性溶剂2-丁酮中的自组装行为及其辐射交联固化效应 认领
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作者 樊凯 李林繁 李吉豪 《辐射研究与辐射工艺学报》 CAS 2021年第1期21-28,共8页
借助Delsa™Nano亚微米粒度粒子动态光散射分析仪、原子力显微镜(AFM)、扫描电子显微镜(SEM)和热重分析仪(TGA)研究了聚苯乙烯-聚丁二烯(PS-b-PB)嵌段共聚物在选择性溶剂2-丁酮中的自组装行为,以及所形成胶束在γ射线辐照后的交联固化效... 借助Delsa™Nano亚微米粒度粒子动态光散射分析仪、原子力显微镜(AFM)、扫描电子显微镜(SEM)和热重分析仪(TGA)研究了聚苯乙烯-聚丁二烯(PS-b-PB)嵌段共聚物在选择性溶剂2-丁酮中的自组装行为,以及所形成胶束在γ射线辐照后的交联固化效应。由于2-丁酮是PS链段的良好溶剂,PB链段的不良溶剂,因此,在适当条件下,PS-b-PB在选择性溶剂中会形成单分散的“核-壳”结构的纳米胶束。而本文的实验结果也表明,通过控制PS-b-PB在溶剂中的质量分数可以在较大范围内调整胶束尺寸。同时,本文进一步通过γ射线辐照的方法,对2-丁酮/PS-b-PB嵌段聚合物体系的胶束溶液进行无氧辐照,结果发现辐照后的胶束无论在微观形貌还是热力学稳定性方面,均有一定的提升,导致这种现象的原因是由于γ射线辐照诱导胶束中的PB链段发生交联反应而固化,固化后的胶束不再受超声震荡、溶剂稀释和挥发等因素的影响。本项研究为制备高分子纳米胶束提供了新的思路和方法。 展开更多
关键词 聚苯乙烯-聚丁二烯(PS-b-PB) 嵌段共聚物 自组装 胶束 γ 射线 交联
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Growth regulation of luminescent gold nanoparticles directed from amphiphilic block copolymers:highly-controlled nanoassemblies toward tailored in-vivo transport 认领
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作者 Liting Nong Tingyao Zhou +2 位作者 Huarui Chen Bing Tang Jinbin Liu 《中国科学:化学英文版》 SCIE EI CAS 2021年第1期157-164,共8页
The understanding of amphiphilic block copolymers(ABC)in encapsulation and transport of inorganic nanomedicines is highly desired.Still,it remains limited due to the challenges in the fabrication of nanoassemblies(NAs... The understanding of amphiphilic block copolymers(ABC)in encapsulation and transport of inorganic nanomedicines is highly desired.Still,it remains limited due to the challenges in the fabrication of nanoassemblies(NAs)with highly-controlled shape and loading of nanoparticles.Herein,through growth regulation of luminescent gold nanoparticles(Au NPs)by different reductants with ABC pluronic F127 as a template,a straightforward strategy is reported for in-situ fabrication of three wellcontrolled gold NAs(Au NAs)that display tunable shapes from spherical to elongated nanostructures and controllable surface chemistry and loading of Au NPs with distinct emissions but identical individual Au NP size.The three Au NAs exhibit tailored invivo transport behaviours:those with spherical shape and more hydrophilic surface show longer blood retention with higher tumor-targeting efficiency(~25.3%injection dose/g)and excellent long-term near-infrared tumor imaging even after 96 h postinjection.These findings provide a useful guidance in designing specific nanostructures for future nanomedicine transport. 展开更多
关键词 luminescence gold nanoparticle self-assembly in-vivo transport imaging
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