Objective To study the significance of authorized generic drugs due to the successive relevant documents issued by China’s government in recent years,which clearly stipulated that China should establish a drug patent...Objective To study the significance of authorized generic drugs due to the successive relevant documents issued by China’s government in recent years,which clearly stipulated that China should establish a drug patent linkage system.Methods The authorized generic drugs play an important role in keeping the balance between brandname drugs and generic drugs in the US.Therefore,this system was investigated,focusing on its difference from independent generics,marketing procedures,application in patent litigation and legitimacy analysis through case evidence.This analogy analysis could provide a reference for the research of authorized generic drug systems in China.Results and Conclusion As an important factor affecting the balance between brand-name drugs and generic drugs,authorized generic drugs should be comprehensively analyzed and discussed,and a suitable system for China’s national conditions should be established by referring to the experiences of the US.展开更多
文摘为研究影响刚性桩复合地基沉降的影响因素,对刚性桩复合地基进行室内压缩试验,基于DUNCAN-CHANG模型利用有限元软件对不同桩长、不同桩径、不同褥垫层厚度和不同桩数(相同置换率)等影响刚性桩复合地基沉降的主要影响因素进行数值模拟.结果表明:随着桩长和桩径的增加,刚性桩复合地基沉降减小,控制桩长比控制桩径对刚性桩复合地基沉降影响效果更加显著,桩侧正负摩阻力的分界点大致在0.4~0.6倍桩长范围内变化,桩土应力比则是在15~17之间变化;当褥垫层厚度较小时,对桩侧摩阻力和桩土之间的受力调节效果不明显,而褥垫层厚度较大时,造成的总体沉降增大,在实际工程中应对褥垫层厚度进行合理设计,建议采用30~50 cm.
文摘Objective To study the significance of authorized generic drugs due to the successive relevant documents issued by China’s government in recent years,which clearly stipulated that China should establish a drug patent linkage system.Methods The authorized generic drugs play an important role in keeping the balance between brandname drugs and generic drugs in the US.Therefore,this system was investigated,focusing on its difference from independent generics,marketing procedures,application in patent litigation and legitimacy analysis through case evidence.This analogy analysis could provide a reference for the research of authorized generic drug systems in China.Results and Conclusion As an important factor affecting the balance between brand-name drugs and generic drugs,authorized generic drugs should be comprehensively analyzed and discussed,and a suitable system for China’s national conditions should be established by referring to the experiences of the US.