Originated in Japan, the <span style="white-space:nowrap;"><i></i></span><i>hikikomori<span style="white-space:nowrap;"></span></i> phenomenon—as a ...Originated in Japan, the <span style="white-space:nowrap;"><i></i></span><i>hikikomori<span style="white-space:nowrap;"></span></i> phenomenon—as a form of individual withdrawal—has progressively widespread and gained international attention, given its psycho-social and economic consequences. In fact, <i><span style="white-space:normal;">hikikomori</span></i> appears today as a problem that cannot be confined solely to the field of mental health. Rather, it appears as a phenomenon that concerns many aspects of modern society, intersecting with medicine, sociology, anthropology, politics, economics, culture and education. In the context of the actual loneliness pandemic, <i><span style="white-space:normal;">hikikomori</span></i> individuals present characteristics that are examined in this article, together with suggestions for its possible management.展开更多
Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and my...Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together,these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses.展开更多
以ISI Web of Science数据库中2006年到2016年的421篇文献为原始数据,应用Citespace知识图谱软件,绘制与害羞研究相关的知识图谱,分析内容包括作者合作分析、研究热点和研究前沿。结果显示:作者合作关系网络中主要以Coplan为中心向外辐...以ISI Web of Science数据库中2006年到2016年的421篇文献为原始数据,应用Citespace知识图谱软件,绘制与害羞研究相关的知识图谱,分析内容包括作者合作分析、研究热点和研究前沿。结果显示:作者合作关系网络中主要以Coplan为中心向外辐射,也包括其他不同处于核心地位的作者,如陈欣银;研究热点涉及害羞与儿童的社会情绪适应(儿童发展、同伴关系、行为问题)和不同文化背景下害羞儿童的发展;研究前沿关注害羞与社交淡漠在社会情绪适应中的差异及保护或风险因素,不同文化背景下害羞儿童的适应,尤其对中国儿童害羞的研究也开始备受关注。展开更多
文摘Originated in Japan, the <span style="white-space:nowrap;"><i></i></span><i>hikikomori<span style="white-space:nowrap;"></span></i> phenomenon—as a form of individual withdrawal—has progressively widespread and gained international attention, given its psycho-social and economic consequences. In fact, <i><span style="white-space:normal;">hikikomori</span></i> appears today as a problem that cannot be confined solely to the field of mental health. Rather, it appears as a phenomenon that concerns many aspects of modern society, intersecting with medicine, sociology, anthropology, politics, economics, culture and education. In the context of the actual loneliness pandemic, <i><span style="white-space:normal;">hikikomori</span></i> individuals present characteristics that are examined in this article, together with suggestions for its possible management.
基金supported by the National Natural Science Foundation of China (31671117).
文摘Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together,these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses.
文摘以ISI Web of Science数据库中2006年到2016年的421篇文献为原始数据,应用Citespace知识图谱软件,绘制与害羞研究相关的知识图谱,分析内容包括作者合作分析、研究热点和研究前沿。结果显示:作者合作关系网络中主要以Coplan为中心向外辐射,也包括其他不同处于核心地位的作者,如陈欣银;研究热点涉及害羞与儿童的社会情绪适应(儿童发展、同伴关系、行为问题)和不同文化背景下害羞儿童的发展;研究前沿关注害羞与社交淡漠在社会情绪适应中的差异及保护或风险因素,不同文化背景下害羞儿童的适应,尤其对中国儿童害羞的研究也开始备受关注。