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The Prognostic and Curative Benefits of Primary Tumor Resection versus No Resection in Stage IV Colorectal Cancer: A Comparative Study 认领
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作者 Ibtsam Shehta Harera Taha A. Baiomy +5 位作者 Ahmed A. Obaya Shady E. Shaker Amr Samir Ahmed M. Elsayed Enas Mahmoud Hamed Loay M. Gertallah 《外科学(英文)》 2020年第3期39-49,共11页
Background: Colorectal cancer (CRC) who is initially diagnosed with single or multiple synchronous distant metastases has an incidence of about 20% of all CRC patients. There is a controversy regarding the role of res... Background: Colorectal cancer (CRC) who is initially diagnosed with single or multiple synchronous distant metastases has an incidence of about 20% of all CRC patients. There is a controversy regarding the role of resection of the primary tumors in those patients. The aim of this study was to explore the prognostic roles and survival advantages of surgical excision of the primary colonic tumor in patients with CRC who are primarily diagnosed with distant metastases. Patients and Methods: We included forty patients who were diagnosed initially with stage IV CRC. We have divided the included patients into two categories the first one included 20 patients that underwent surgical excision of the primary cancer followed by administration of chemotherapy and the remaining 20 patients were initially given chemotherapy without excision of the cancer. We followed patients for 24 months to detect progression, response to chemotherapy, recurrence free survival and overall survival rates. Results: There is statistically significant difference between patients underwent different initial management techniques regarding N stage of the tumor (p = 0.039), response to chemotherapy (p = 0.048), occurrence of relapse (p = 0.022), disease free survival (DFS) (p = 0.027) or overall survival (OS) rates (p = 0.001) (DFS and OS were significantly higher among patients who received initial surgical management. Primary surgical removal of the tumor improved OS rate by 8 months (p = 0.001). Conclusion: Surgical removal of the primary malignancy in mCRC patients before chemotherapy administration improves patients’ survival rates and response to chemotherapy that lead to a better prognosis. 展开更多
关键词 METASTATIC CRC (mCRC) Surgical RESECTION Chemotherapy Survival
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Mutation Analysis of EGFR Gene in Patients with Non-Small Cell Lung Cancer in Xinjiang 认领
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作者 Yi Shi Xuelian Pang +3 位作者 Zhiping Ma Wenli Cui Yuqing Ma Wei Zhang 《临床医学国际期刊(英文)》 2020年第4期144-153,共10页
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic ... The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic target for human malignancies, due to its frequent hyperactivation, therefore, it is necessary to investigate the characteristics of EGFR mutation, and identify patients who are likely to benefit from EGFR mutation. In this study, we examined 766 non-small cell lung cancer (NSCLC) patients (675 tissue, 83 thoracic water precipitation and 8 plasma samples) tested in pathology department of First Affiliated Hospital of Xinjiang Medical University from 2013 to 2017 by using ARMS-PCR method. The correlation between EGFR mutations and clinical pathological features was further explored. Subgroup analyses according to ethnicity, histological type, sample type, and tumour grade were done. Subgroup analyses showed the mutation rate of tumor tissue, thoracic water precipitation and plasm was 30.5%, 37.3%, 50.0% respectively. We found female (p < 0.0001), no smoking (p < 0.001), adenocarcinoma (p < 0.0001), and tissue specimens (Tobacco use) were associated with higher EGFR mutation rate. The most common mutations were exon 19 deletions (47.30%) and L858R point (42.32%) mutation. We have not found any differences between EGFR mutations and ethnic groups especially. In addition, we did not find differences in common mutations and rare sensitive mutations in the survival of targeted therapies. 展开更多
关键词 NON-SMALL Cell LUNG Cancer EGFR MUTATIONS SURVIVAL
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2003—2013年广东省中山市主要癌症净生存率分析 认领
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作者 魏矿荣 梁智恒 李柱明 《中国肿瘤》 CAS CSCD 北大核心 2020年第2期103-107,共5页
[目的]评价中山市癌症防治效果。[方法]收集整理2003—20013年诊断、户籍为广东省中山市的主要癌症的生存资料,统计分析其净生存率。[结果]2003—2013年期间,中山市共有符合研究条件的18种主要癌症患者26046例,不同癌症5年标化净生存率... [目的]评价中山市癌症防治效果。[方法]收集整理2003—20013年诊断、户籍为广东省中山市的主要癌症的生存资料,统计分析其净生存率。[结果]2003—2013年期间,中山市共有符合研究条件的18种主要癌症患者26046例,不同癌症5年标化净生存率明显不同。2010—2013年主要癌症5年标化净生存率位于11.7%~74.5%,女性乳腺癌最高,食管癌最低,女性乳腺癌、宫颈癌、结肠癌、儿童急性淋巴母细胞性白血病、直肠癌和前列腺癌的5年标化净生存率>50%,成人淋巴性恶性肿瘤和脑肿瘤,卵巢癌和儿童脑肿瘤的5年标化净生存率位于30%~50%之间,食管、胰腺、肝、肺和胃癌与成人髓样恶性肿瘤的5年标化净生存率<30%。多数癌症的5年标化净生存率比1995—1999年明显上升。[结论]2010—2013年中山市多数主要癌症生存率位于全球CONCORD-3参与地区的中低或较低水平,提示中山市应采取措施以提高其人群癌症生存率。 展开更多
关键词 癌症 生存 5年标化净生存率 广东
Field Durability of <i>Yorkool<sup>®</sup>LN</i>Nets in the Benin Republic 认领
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作者 I. B. Ahogni R. Y. Aï +14 位作者 kpon R. A. Ossè J. F. Dagnon R. Govoetchan R. H. Attolou A. Agbevo R. Azondekon C. Z. Koukpo V. Gnanguenon H. Sagbohan C. Kpanou F. Tokponon B. Akinro G. G. Padonou M. C. Akogbeto 《昆虫学(英文)》 2020年第1期72-92,共21页
Context: Recent publications on WHO recommended methods for estimating the survival of LLINs are good guidelines for assessing the performance of long-lasting insecticidal nets (LLINs). Thus, this field trial study wa... Context: Recent publications on WHO recommended methods for estimating the survival of LLINs are good guidelines for assessing the performance of long-lasting insecticidal nets (LLINs). Thus, this field trial study was undertaken to evaluate the durability of the Yorkool? LN mosquito net distributed during the 2017 campaign in Benin. Methods: The monitoring of Yorkool? LN nets was carried out in two districts (Djougou III and Barienou) in Djougou, department of Donga, northern Benin from October 2017 to March 2019. A representative sample of 250 households that had received the Yorkool? LN polyester LLINs during the 2017 campaign was selected in the rural and urban areas of each district and monitored for 6, 12 and 18 months. An evaluation of the survival of Yorkool? LN nets was conducted based on the rate of loss and physical condition of the surviving nets as measured by the proportional hole index (pHI). Finally, the chemical efficacy of these LLINs during each period was determined using the WHO cone tests. Results: Survival of Yorkool? LN nets was similar in both rural and urban areas, although there was a difference in survival between the 6-month (95.3%), 12-month (89.7%), and 18-month follow-up periods (74.4%). A difference in survival was also observed between the NetCalc model (84%) compared to the Yorkool? LN nets of this study (74.4%). The attrition rate was 29.6% for LLINs at 18 months. Surprisingly, the physical integrity of the LLINs was minimally affected in the municipality. Indeed, the proportion of mosquito nets in good condition without a hole was 51.8% compared to 56.8% with a hole after 18 months. Only 7.8% of the LLINs in the two districts were damaged compared to 2.6% which needed to be replaced. The washing frequency, location of the LLINs and the frequency of use are some factors contributing to the appearance of the holes in LLINs. The bio-efficacy results of LLINs based on the cone test were good with mortality rates of 74%, 66%, 72% and 58% respectively after baseline, 6, 12 and 18 mo 展开更多
关键词 DURABILITY Yorkool? LN LLINs Survival Physical INTEGRITY Bio-Efficacy
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Survival of Juvenile <i>Acer grandidentatum</i>Nutt. (Bigtooth Maple, Aceraceae) in Central Texas Woodlands 认领
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作者 O. W. Van Auken D. L. Taylor 《美国植物学期刊(英文)》 2020年第3期413-425,共13页
Populations of Acer grandidentatum Nutt. (Bigtooth maple, Aceraceae = Sapindaceae) in central Texas are mostly found in isolated, deep, relatively remote, limestone canyons. Acer grandidentatum is found with a few oth... Populations of Acer grandidentatum Nutt. (Bigtooth maple, Aceraceae = Sapindaceae) in central Texas are mostly found in isolated, deep, relatively remote, limestone canyons. Acer grandidentatum is found with a few other mostly deciduous species. Recruitment of juveniles has been reported to be lacking. One population of A. grandidentatum juveniles was found in a limestone canyon in a State Natural Area in Central Texas. Fifty juveniles were located. Wire enclosures were placed around half of the seedlings with half left in the open. In an adjacent canyon, 50 juvenile seedlings were planted in a similar habitat with adult A. grandidentatum trees nearby. Half were in enclosures and half in the open. Plant survival was followed for four growing seasons until November 2019. At the end of that time when survivals were compared between plants in enclosures and those in the open in both canyon communities, there was a significant difference in survival in both communities (χ2, P < 0.001). Survival in the planted population in enclosures was 92% with 52% in the open. In the natural population in enclosures 68% survived, with 32% survivals in the open. When population extinction was compared, extinction for planted juveniles in enclosures using linear regression was 60.5 yrs and it was 11.9 yrs in the open. For native juveniles, it was 12.6 yrs in enclosures and 5.9 yrs in the open. The cause of most mortalities in the open seemed to be herbivory by white-tailed deer (Odocoleus virginianus). 展开更多
关键词 SURVIVAL Mortality Populations EDWARDS Plateau Rare Plants Seedlings WOODLANDS Dynamics
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Prolonged progression-free survival and overall survival are associated with diabetes mellitus but inversely associated with levels of blood glucose in patients with lung cancer 认领
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作者 Ning-Fang Wang Hong-Mei Tang +1 位作者 Fang-Lei Liu Qun-Ying Hong 《中华医学杂志:英文版》 SCIE CAS CSCD 2020年第7期786-791,共6页
Background:Previous studies have provided conflicting evidence about the increased overall survival(OS)in lung cancer patients with diabetes mellitus(DM)compared with those without DM.This study assessed progression-f... Background:Previous studies have provided conflicting evidence about the increased overall survival(OS)in lung cancer patients with diabetes mellitus(DM)compared with those without DM.This study assessed progression-free survival(PFS)/OS in lung cancer patients with or without DM and tentatively analyzed the impact of blood glucose levels on PFS/OS in lung cancer patients.Methods:Data were collected from lung cancer patients based upon admission records from January 2010 to January 2012 and follow-up records from January 2010 to January 2015 in the Department of Pulmonary Medicine,Zhongshan Hospital,Fudan University,Shanghai.The data included patient sex,age,body mass index(BMI),smoking status,history of DM,level of blood glucose,pathological type,clinical stage of cancer,chemotherapy regimen,and history of anti-DM drugs.The Cox regression model and Kaplan-Meier method were used for the analysis of hazard factors and PFS/OS.For comparison of PFS/OS in lung cancer with or without DM,patients were divided into three groups:lung cancer with DM,lung cancer without DM but with elevated level of blood glucose,lung cancer without DM or elevated level of blood glucose.Results:In total,the data from 200 lung cancer patients(138 males/62 females,aged 29.0 to 78.0 years,mean 60.0±8.6 years)were collected.For the comparison of PFS/OS in lung cancer patients with or without DM,patients were divided into three groups:lung cancer with DM(n=31);lung cancer without DM but with elevated levels of blood glucose(n=40);and lung cancer without both DM and elevated levels of blood glucose(n=128),whereas 1 patient dropped out of the study.All the patients underwent complete chemotherapy and were followed up for 36.0 to 60.0 months.Kaplan-Meier survival analysis showed that lung cancer patients with DM had increased PFS and OS compared with those without DM(log-rank,P<0.05,P<0.01);the median PFS in lung cancer with DM was 12.0 months(95%confidence interval[CI],4.0-16.0)vs.6.0 months in those without DM(95%CI,5.8-6.3);and the median OS i 展开更多
关键词 Diabetes MELLITUS Lung cancer Overall SURVIVAL Progression-free SURVIVAL Serum glucose level
Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours 认领
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作者 Jaseela Chiramel Rose Almond +11 位作者 Astrid Slagter Adeel Khan Xin Wang Kok Haw Jonathan Lim Melissa Frizziero Bipasha Chakrabarty Annamaria Minicozzi Angela Lamarca Wasat Mansoor Richard A Hubner Juan William Valle Mairéad Geraldine McNamara 《世界临床肿瘤学杂志:英文版》 2020年第4期205-216,共12页
BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many s... BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy AIM To evaluate the effect of lymph node(LN)status and yield on relapse-free survival(RFS)and overall survival(OS)in patients with resected GEP NETs.METHODS Data on patients who underwent curative resection for GEP NETs between January 2002 and March 2017 were analysed retrospectively.Grade 3 tumours(Ki67>20%)were excluded.Univariate Cox proportional hazard models were computed for RFS and OS and assessed alongside cut-point analysis to distinguish a suitable binary categorisation of total LNs retrieved associated with RFS.RESULTS A total of 217 patients were included in the study.The median age was 59 years(21-97 years)and 51%(n=111)were male.Primary tumour sites were small bowel(42%),pancreas(25%),appendix(18%),rectum(7%),colon(3%),gastric(2%),others(2%).Median follow up times for all patients were 41 mo(95%CI:36-51)and 71 mo(95%CI:63–76)for RFS and OS respectively;50 relapses and 35 deaths were reported.LNs were retrieved in 151 patients.Eight or more LNs were harvested in 106 patients and LN positivity reported in 114 patients.Three or more positive LNs were detected in 62 cases.The result of univariate analysis suggested perineural invasion(P=0.0023),LN positivity(P=0.033),LN retrieval of≥8(P=0.047)and localisation(P=0.0049)have a statistically significant association with shorter RFS,but there was no effect of LN ratio on RFS:P=0.1 or OS:P=0.75.Tumour necrosis(P=0.021)and perineural invasion(P=0.016)were the only two variables significantly associated with worse OS.In the final multivariable analysis,localisation(pancreas HR=27.33,P=0.006,small bowel HR=32.44,P=0.005),and retrieval of≥8 LNs(HR=2.7,P=0.036)were independent prognostic factors 展开更多
关键词 Well differentiated neuroendocrine tumours Pancreatic neuroendocrine tumours Small intestinal neuroendocrine tumours Ki67 Lymph node ratio Lymph node retrieval Lymph node positivity Relapse-free survival Overall survival
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Nomograms predicting long-term survival in patients with invasive intraductal papillary mucinous neoplasms of the pancreas:A population-based study 认领
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作者 Jia-Yuan Wu Yu-Feng Wang +2 位作者 Huan Ma Sha-Sha Li Hui-Lai Miao 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第5期535-549,共15页
BACKGROUND There are few effective tools to predict survival in patients with invasive intraductal papillary mucinous neoplasms of the pancreas.AIM To develop comprehensive nomograms to individually estimate the survi... BACKGROUND There are few effective tools to predict survival in patients with invasive intraductal papillary mucinous neoplasms of the pancreas.AIM To develop comprehensive nomograms to individually estimate the survival outcome of patients with invasive intraductal papillary mucinous neoplasms of the pancreas.METHODS Data of 1219 patients with invasive intraductal papillary mucinous neoplasms after resection were extracted from the Surveillance,Epidemiology,and End Results database,and randomly divided into the training(n=853)and the validation(n=366)cohorts.Based on the Cox regression model,nomograms were constructed to predict overall survival and cancer-specific survival for an individual patient.The performance of the nomograms was measured according to discrimination,calibration,and clinical utility.Moreover,we compared the predictive accuracy of the nomograms with that of the traditional staging system.RESULTS In the training cohort,age,marital status,histological type,T stage,N stage,M stage,and chemotherapy were selected to construct nomograms.Compared with the American Joint Committee on Cancer 7th staging system,the nomograms were generally more discriminative.The nomograms passed the calibration steps by showing high consistency between actual probability and nomogram prediction.Categorial net classification improvements and integrated discrimination improvements suggested that the predictive accuracy of the nomograms exceeded that of the American Joint Committee on Cancer staging system.With respect to decision curve analyses,the nomograms exhibited more preferable net benefit gains than the staging system across a wide range of threshold probabilities.CONCLUSION The nomograms show improved predictive accuracy,discrimination capability,and clinical utility,which can be used as reliable tools for risk classification and treatment recommendations. 展开更多
关键词 INVASIVE INTRADUCTAL papillary MUCINOUS neoplasm PANCREAS Nomogram Overall SURVIVAL Cancer-specific SURVIVAL Surgical resection
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Transcriptional responses to starvation of pathogenic Vibrio harveyi strain DY1 认领
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作者 LIU Xiaodan GAO Xiaojian +4 位作者 CHEN Nan ZHANG Yingying LI Xixi ZHANG Yue ZHANG Xiaojun 《海洋湖沼学报(英文)》 SCIE CAS CSCD 2020年第2期579-587,共9页
Vibrio harveyi is a pathogen of various aquatic organisms that has been recently associated with massive mortality episodes in the aquaculture industry.Recurrent outbreaks of vibriosis are closely correlated with the ... Vibrio harveyi is a pathogen of various aquatic organisms that has been recently associated with massive mortality episodes in the aquaculture industry.Recurrent outbreaks of vibriosis are closely correlated with the capacity of this bacterial species to survive long-term starvation conditions.To study the regulation mechanism of gene expression at the transcriptional level in V.harveyi under starvation conditions,the transcriptomic response profiles were determined of the Portunus trituberculatus pathogen V.harveyi strain DY1 under normal conditions and after four weeks of starvation.A total of 4679 and 4661 genes were expressed in the non-starved and starved cells,respectively.The significantly differentially expressed genes(DEGs)between non-starved and starved groups were identified,in which 255 genes were up-regulated and 411 genes were down-regulated.GO analysis and KEGG enrichment analysis were used to analyze the DEGs and revealed the involvement of these DEGs in many pathways,including ABC transporters,flagellum assembly,and fatty acid metabolism.Several DEGs were randomly selected and their expression levels were confirmed by quantitative real-time PCR(qRT-PCR).This is the first comprehensive transcriptomic analysis of starvation ef fects in V.harveyi.Our findings will facilitate future study on stress adaptation and survival mechanisms of V.harveyi. 展开更多
关键词 VIBRIO HARVEYI STARVATION stress TRANSCRIPTOME sequencing DIFFERENTIALLY expressed genes adaptation and survival mechanisms
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“多花黑麦草-水稻”轮作对稻瘟病发生程度的影响 认领
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作者 颜志波 赵甜 +2 位作者 王方海 辛国荣 李广宏 《草学》 2020年第2期54-58,64共6页
2016~2017年在湘西水稻两熟制地区开展了冬种黑麦草对稻瘟病菌越冬存活力及后作水稻稻瘟病发生的影响研究。结果显示,冬种黑麦草田残留稻兜上的稻瘟病越冬菌丝随越冬时间的推进,存活率从2016年12月的72.80%显著下降到2017年4月的52.80%... 2016~2017年在湘西水稻两熟制地区开展了冬种黑麦草对稻瘟病菌越冬存活力及后作水稻稻瘟病发生的影响研究。结果显示,冬种黑麦草田残留稻兜上的稻瘟病越冬菌丝随越冬时间的推进,存活率从2016年12月的72.80%显著下降到2017年4月的52.80%,冬闲田无明显下降。从越冬病菌产孢量看,冬种黑麦草田稻兜的稻瘟病菌产孢数量从2016年12月至2017年4月均在显著减少,冬闲田则从2016年12月至2017年2月减少显著,2017年2月到4月降低不显著;比较同一调查时间冬种黑麦草田与冬闲田越冬病菌产孢量,发现冬种黑麦草田的越冬病菌产孢量均比冬闲田显著降低。在冬种黑麦草对后作水稻稻瘟病发生的影响上,在同一调查时间,无论是病叶(穗)率还是病情指数,冬种黑麦草田均显著低于冬闲田,其中2017年7月、8月和9月冬种黑麦草田的病叶(穗)率分别比同时期冬闲田的病叶(穗)率低52.83%、26.97%和20.61%,病情指数分别低66.82%、45.48%和39.84%。冬种黑麦草对后作水稻稻瘟病发生的控制以2017年7月最高,为40.05%,8月和9月的控病率分别为31.26%和28.49%。综合以上结果,在稻区实施冬季种植黑麦草,不仅能够显著降低稻瘟病越冬菌丝的存活率,而且也显著降低越冬病菌的产孢数,有效减少后作水稻稻瘟病的初侵染源,并在一定程度上降低后作水稻稻瘟病的发生。 展开更多
关键词 黑麦草-水稻轮作 稻瘟病 越冬病原菌 存活力 发生程度
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晚期癌痛居家宁养患者生存期及其相关因素分析 认领
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作者 杨超 沈超 +3 位作者 陈柳 施丽霞 于瑞华 沈伟 《中国肿瘤》 CAS CSCD 北大核心 2020年第3期235-240,共6页
[目的]通过对晚期癌痛居家患者的基本状况、癌痛强度、活动能力、生活质量、生存期的调查,分析其生活现状及其相关影响因素,构建晚期癌痛居家患者生存模型。[方法]选取310例上海市崇明地区晚期癌痛居家患者作为统计分析对象,分析患者疼... [目的]通过对晚期癌痛居家患者的基本状况、癌痛强度、活动能力、生活质量、生存期的调查,分析其生活现状及其相关影响因素,构建晚期癌痛居家患者生存模型。[方法]选取310例上海市崇明地区晚期癌痛居家患者作为统计分析对象,分析患者疼痛强度数字评分、活动能力、生活质量及生存期与患者性别、年龄、文化水平、居住情况、家庭人均月收入、肿瘤种类之间的相关性,并利用自适应助推法(adaptive boosting)构建晚期癌痛居家患者生存期分类模型。[结果]晚期癌痛居家患者的生存期与患者疼痛数字评分呈负相关,与活动能力评分、生活质量评分呈正相关,患者基本状况包括性别、年龄、文化水平、居住情况、家庭人均月收入和肿瘤种类,都是影响晚期癌痛居家肿瘤患者生存期的直接或间接因素。基于以上研究结果构建了分类正确率约为70%的晚期癌痛居家患者生存期分类模型。[结论]晚期癌痛居家患者作为一个特殊的弱势群体,影响其生活质量及生存期的因素较为复杂,通过adaptive boosting算法构建的分类模型可以为居家医疗服务提供参考意见。 展开更多
关键词 癌痛 居家医疗服务 生存期 生活质量 分类模型
经导管动脉栓塞化疗联合冷循环微波消融治疗原发性肝癌的远期随访研究 认领
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作者 徐超 王媛 +3 位作者 贾秀青 刘晓英 尹雯 冯庆亮 《癌症进展》 2020年第6期614-617,共4页
目的探讨经导管动脉栓塞化疗(TACE)联合冷循环微波消融治疗原发性肝癌的远期疗效。方法根据治疗方式的不同将73例原发性肝癌患者分为对照组(仅行TACE治疗)39例和联合组(行冷循环微波消融联合TACE治疗)34例,比较两组患者的术后生存、局... 目的探讨经导管动脉栓塞化疗(TACE)联合冷循环微波消融治疗原发性肝癌的远期疗效。方法根据治疗方式的不同将73例原发性肝癌患者分为对照组(仅行TACE治疗)39例和联合组(行冷循环微波消融联合TACE治疗)34例,比较两组患者的术后生存、局部复发和远处转移情况。结果截至随访结束,联合组与对照组患者的术后1、2年生存率比较,差异均无统计学意义(P﹥0.05);联合组患者的术后3年生存率高于对照组,中位生存时间长于对照组(P﹤0.05)。两组患者的术后1年局部复发率比较,差异无统计学意义(P﹥0.05);联合组患者的术后第2、3年局部复发率均低于对照组(P﹤0.05)。两组患者的第1、2、3年远处转移率比较,差异均无统计学意义(P﹥0.05)。结论对于原发性肝癌患者,冷循环微波消融联合TACE对于提高生存率、延长生存时间、降低局部复发率均具有一定作用。 展开更多
关键词 冷循环微波消融 经导管动脉栓塞化疗 原发性肝癌 生存 复发 远处转移
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BUB1基因在胃癌组织中高表达:基于Oncomine数据库及生物信息学方法 认领
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作者 李小燕 何杰 +2 位作者 余觅 张维 孙建 《南方医科大学学报》 CAS CSCD 北大核心 2020年第5期683-692,共10页
目的探讨细胞周期有丝分裂纺锤体检测点丝/苏氨酸激酶(BUB1)基因在胃癌(STAD)中的表达及临床价值。方法分别运用Oncomine、GEPIA、BioGPS和Kaplan-Meier Plotter等数据库分析BUB1基因在胃癌组织和正常胃组织的表达差异,并且分析BUB1表... 目的探讨细胞周期有丝分裂纺锤体检测点丝/苏氨酸激酶(BUB1)基因在胃癌(STAD)中的表达及临床价值。方法分别运用Oncomine、GEPIA、BioGPS和Kaplan-Meier Plotter等数据库分析BUB1基因在胃癌组织和正常胃组织的表达差异,并且分析BUB1表达水平与胃癌患者生存预后之间的关系;利用癌症细胞系全科百科全书(CCLE)分析BUB1分别在胃癌组织T细胞和B细胞中的表达,利用String数据库绘制BUB1相关蛋白网络图及基因本体(GO)功能注释,并对京都基因和基因组百科全书(KEGG)相关通路进行分析。采用肿瘤免疫评估资源(TIMER)数据库分析BUB1在免疫浸润物中的表达及对胃癌患者生存预后的影响。为进一步验证Oncomine数据库基因芯片的结果,我们选择成都医学院第一附属医院2018年3月~2019年7月收治的胃癌患者30例,经外科手术获得胃腺癌组织30份,同时获取的癌旁正常组织30份作为对照组,通过PCR和免疫组化技术对Oncomine数据库中BUB1基因表达的数据进行验证。结果Oncomine、GEPIA、BioGPS分析显示:与正常胃组织相比,BUB1在胃癌组织中呈现高表达(P<0.05)。通过Kaplan-Meier生存分析发现,BUB1基因高表达的胃癌患者无进展生存期(HR=0.52,95%CI=0.41~0.67,P<0.05)、总生存期(HR=0.67,95%CI=0.55~0.82,P<0.05)均有所延长。通过string数据收集到与BUB1相关蛋白主要富集于13类细胞学组分、4类分子功能和12类生物学过程,并参与了4条信号通路。TIMER数据库分析显示在免疫微环境中高表达BUB1 mRNA的CD4+T细胞和巨噬细胞对胃癌患者5年生存预后较好。实时定量PCR结果提示胃癌组织样本BUB1的表达水平(4.345±0.421)明显高于配对的癌旁正常胃粘膜组织(1.583±0.122)(t=34.63,P<0.05);免疫组化结果提示胃癌组织BUB1染色成阳性。结论胃癌组织中BUB1基因呈现高表达,BUB1可能具有减少肿瘤免疫抑制作用可协助评估胃癌患者的预后情况。 展开更多
关键词 BUB1基因 胃癌 生存期 生物信息学
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周期性饥饿再投喂对长蛸存活、生长以及肌肉脂肪酸和氨基酸的影响 认领
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作者 宋旻鹏 汪金海 +2 位作者 陈智威 李希豹 郑小东 《水生生物学报》 CAS CSCD 北大核心 2020年第2期372-378,共7页
在19.8—22.2℃条件下,采用周期性饥饿再投喂的方法,研究不同投喂模式对长蛸[Octopus minor,初始体重(94.29±9.35)g,初始胴背长(53.25±5.25)mm]的存活、生长以及脂肪酸和氨基酸的影响。实验分为4个组包括对照组(持续投喂)、S... 在19.8—22.2℃条件下,采用周期性饥饿再投喂的方法,研究不同投喂模式对长蛸[Octopus minor,初始体重(94.29±9.35)g,初始胴背长(53.25±5.25)mm]的存活、生长以及脂肪酸和氨基酸的影响。实验分为4个组包括对照组(持续投喂)、S1F5组(周期性饥饿1d再投喂5d)、S2F4组(周期性饥饿2d再投喂4d)和S3F3组(周期性饥饿3d再投喂3d),持续24d。实验结果如下:随饥饿时间的延长,增重率、肝体比、体重变化量以及终末体重四个指标均呈现出先上升后下降的趋势,其中S1F5组的值均显著高于对照组,而S3F3组的值除肝体比外均显著低于对照组。长蛸的成活率随饥饿时间的增长呈现出下降趋势,但各实验组均与对照组差异不显著;摄食量随饥饿时间的延长,表现出上升趋势,且三个实验组的值均显著高于对照组。在长蛸肌肉脂肪酸中,饱和脂肪酸(SFA)、不饱和脂肪酸(UFA)、单不饱和脂肪酸(MUFA)以及多不饱和脂肪酸(PUFA)的含量均与对照组差异不显著,但S1F5组的值与对照组相比出现了一定程度的升高;在氨基酸含量上,各实验组的必需氨基酸总量(TEAA)、氨基酸总量(TAA)以及必需氨基酸总量/氨基酸总量(TEAA/TAA)的值均与对照组差异不显著。综上所述,S1F5组和S2F4组长蛸出现了补偿生长现象,且S1F5组长蛸具备超补偿生长能力。因此,在长蛸的人工养殖过程中,为保证其养殖效果,建议采用周期性饥饿1d再投喂5d的投喂模式。 展开更多
关键词 长蛸 饥饿再投喂 存活 生长 脂肪酸 氨基酸
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Evaluation of subtropical ornamental trees for reclaiming salinity affected lands 认领
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作者 Jagreeti Gupta R.K.Dubey +1 位作者 Nirmaljit Kaur O.P.Choudhary 《林业研究:英文版》 SCIE CAS CSCD 2020年第3期807-817,共11页
This study was conducted to evaluate the tolerance of 1-year-old seedlings of ten subtropical ornamental tree species against a range of salinity levels of Na Cl from May 2015 to October 2015. The levels were further ... This study was conducted to evaluate the tolerance of 1-year-old seedlings of ten subtropical ornamental tree species against a range of salinity levels of Na Cl from May 2015 to October 2015. The levels were further enhanced from November to April 2017 as 100% survival was observed in the initial concentrations for all species.The seedlings were grown during the first week of April2015 in 1000 earthen pots containing soil: farmyard manure(2:1), irrigated with tap water for 1 month followed by saline irrigation in May by maintaining electrical conductivity at 0.75, 1.00, 1.25, 1.50, 2.25, and 3.00 d S/m for 30,40, 50, 60, 90, and 120 m M Na Cl. Every 3 months,heights, relative leaf water content, and percent survival were determined;total soluble sugars of the upper leaves of each tree were quantified. All species exhibited consistent early growth and survival when supplied with 30, 40, 50 and 60 m M of Na Cl. Koelreutaria paniculata, Ficus benjamina, Putranjiva roxburghii, Bauhinia purpurea and Millettia ovalifolia were sensitive to elevated salinity levels and did not survive at the highest salt concentrations of 90 and 120 m M. 展开更多
关键词 Saline irrigation Ornamental trees Relative leaf water content Survival OSMOLYTES
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肝癌流行现况和趋势分析 认领
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作者 应倩 汪媛 《中国肿瘤》 CAS CSCD 北大核心 2020年第3期185-191,共7页
近年来,全球大部分国家和地区的肝癌发病率呈现上升趋势,但也有资料显示部分国家和地区在过去的数十年中肝癌发病率总趋势呈下降趋势。亚洲国家过去数十年肝癌死亡率总的趋势似有下降。该文主要结合GLOBOCAN2018及《中国肿瘤登记年报》... 近年来,全球大部分国家和地区的肝癌发病率呈现上升趋势,但也有资料显示部分国家和地区在过去的数十年中肝癌发病率总趋势呈下降趋势。亚洲国家过去数十年肝癌死亡率总的趋势似有下降。该文主要结合GLOBOCAN2018及《中国肿瘤登记年报》等资料及相关文献,对肝癌流行情况及变化趋势进行分析。 展开更多
关键词 肝癌 发病率 死亡率 生存率
miR-144通过影响TLR/MyD88通路抑制肝癌SMMC-7721细胞侵袭 认领
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作者 易青松 柳久久 +3 位作者 艾热夏提·库尔班 李竞 罗宏武 孙吉春 《南方医科大学学报》 CAS CSCD 北大核心 2020年第5期765-770,F0003,共7页
目的探讨miR-144基因过表达对肝癌SMMC-7721细胞侵袭及Toll样受体(TLR)/髓样分化因子88(MyD88)免疫通路的影响。方法培养人正常肝细胞HL-7702,肝癌细胞系SMMC-7721,采用荧光实时定量PCR法检测两组细胞miR-144基因表达差异,将SMMC-7721... 目的探讨miR-144基因过表达对肝癌SMMC-7721细胞侵袭及Toll样受体(TLR)/髓样分化因子88(MyD88)免疫通路的影响。方法培养人正常肝细胞HL-7702,肝癌细胞系SMMC-7721,采用荧光实时定量PCR法检测两组细胞miR-144基因表达差异,将SMMC-7721细胞分为空白组、miR-144 NC组、miR-144 mimics组,倒置荧光显微镜检测转染效率,qRT-PCR法检测转染后各组miR-144基因表达情况,通过细胞计数试剂盒(CCK8)法各组SMMC-7721细胞存活情况,通过Transwell法检测各组SMMC-7721细胞侵袭情况,应用免疫印迹法检测各组侵袭相关蛋白基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)以及TLR/MyD88通路相关蛋白表达情况,观察添加40μmol/L MyD88抑制剂TJ-M2010-2组对SMMC-7721细胞TLR/MyD88通路相关蛋白表达情况。结果与正常组相比,SMMC-7721组miR-144基因相对表达量显著降低(P<0.05);与空白组、miR-144 NC组相比,miR-144 mimics组miR-144基因表达显著升高(P<0.05);CCK-8实验显示,与对照组、miR-144 NC组相比,miR-144 mimics组转染48、72、96 h后细胞存活率显著降低(P<0.05);与空白组、miR-144 NC组相比,miR-144 mimics组侵袭细胞数、MMP-2、MMP-9蛋白表达显著降低(P<0.05);与空白组、miR-144 NC组相比,miR-144 mimics组、TJ-M2010-2组Toll样受体4(TLR4)、MyD88、磷酸化核因子-κB(p-NF-κB)/核因子-κB(NF-κB)蛋白表达显著降低(P<0.05),miR-144 mimics组与TJ-M2010-2组TLR4、MyD88、p-NF-κB/NF-κB蛋白表达差异无统计学意义(P>0.05)。结论miR-144过表达可能通过抑制TLR/MyD88通路转导降低SMMC-7721细胞存活、抑制SMMC-7721细胞侵袭。 展开更多
关键词 SMMC-7721细胞 miR-144 存活 侵袭 Toll样受体/髓样分化因子88
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恶性淋巴瘤患者自体造血干细胞移植治疗后的生存及预后因素分析 认领
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作者 王清松 王凌云 王萍 《实用癌症杂志》 2020年第5期756-759,共4页
目的探讨恶性淋巴瘤患者自体造血干细胞移植治疗后的生存及预后因素。方法收集72例进行自体造血干细胞移植治疗的恶性淋巴瘤患者临床资料,另收集同期收治的采用单纯化疗方案治疗的50例恶性淋巴瘤患者临床资料,所有患者均获得3~63个月随... 目的探讨恶性淋巴瘤患者自体造血干细胞移植治疗后的生存及预后因素。方法收集72例进行自体造血干细胞移植治疗的恶性淋巴瘤患者临床资料,另收集同期收治的采用单纯化疗方案治疗的50例恶性淋巴瘤患者临床资料,所有患者均获得3~63个月随访,统计其生存情况,并分析自体造血干细胞移植治疗患者预后影响因素。结果所有患者均获得有效随访,截止随访时间,自体造血干细胞移植治疗患者存活率高于单纯化疗患者(P<0.05)。单因素分析显示,自体造血干细胞移植治疗生存组骨髓侵犯、B症状、IPI评分、移植前状态、乳酸脱氢酶(LDH)水平与死亡组存在差异(P<0.05)。COX比例风险回归模型显示,移植前状态是否为完全缓解(CR)是影响自体造血干细胞移植治疗患者预后的独立因素(P<0.05)。结论自体造血干细胞移植治疗可改善恶性淋巴瘤患者生存状况,其预后与移植前状态有关。 展开更多
关键词 恶性淋巴瘤 自体造血干细胞移植 生存情况 预后影响因素
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A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy 认领
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作者 Ho Kyoung Hwang Keita Wada +8 位作者 Ha Yan Kim Yuichi Nagakawa Yosuke Hijikata Yota Kawasaki Yoshiharu Nakamura Lip Seng Lee Dong Sup Yoon Woo Jung Lee Chang Moo Kang 《中国癌症研究:英文版》 SCIE CAS CSCD 2020年第1期105-114,共10页
Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical ... Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. However, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term survival.Methods: The medical records of patients who underwent pancreatectomy following neoadjuvant treatment from January 2005 to December 2016 at Severance Hospital were retrospectively reviewed. Medical records were collected from five international institutions from Japan and Singapore for external validation.Results: A total of 113 patients were enrolled. The nomogram for predicting 1-year disease-specific survival was created based on 5 clinically detectable preoperative parameters as follows: age(year), symptom(no/yes), tumor size at initial diagnostic stage(cm), preoperative serum carbohydrate antigen(CA) 19-9 level after neoadjuvant treatment(<34/≥34 U/m L), and planned surgery [pancreaticoduodenectomy(PD)(pylorus-preserving PD)/distal pancreatectomy(DP)/total pancreatectomy]. Model performance was assessed for discrimination and calibration.The calibration plot showed good agreement between actual and predicted survival probabilities;the the Greenwood-Nam-D’Agostino(GND) goodness-of-fit test showed that the model was well calibrated(χ~2=8.24,P=0.5099). A total of 84 patients were used for external validation. When correlating actual disease-specific survival and calculated 1-year disease-specific survival, there were significance differences according to the calculated probability of 1-year survival among the three groups(P=0.044).Conclusions: The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of pancreatic cancer. 展开更多
关键词 PANCREATIC cancer NEOADJUVANT treatment PANCREATECTOMY survival NOMOGRAM
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生存·苦痛·乡愁——论“打工诗歌”的抒写角度 认领
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作者 王红 《柳州职业技术学院学报》 2020年第1期102-105,共4页
随着改革开放的发展,外出打工热潮随之而来,与此同时也涌现一批打工诗人,他们把亲身经历写作朴实的诗歌,通过诗歌的语言为底层工作者代言,为他们发声,诉说着他们生存的苦痛与乡愁。从城市到农村间的游走带来的是身与心的疼痛和对家的无... 随着改革开放的发展,外出打工热潮随之而来,与此同时也涌现一批打工诗人,他们把亲身经历写作朴实的诗歌,通过诗歌的语言为底层工作者代言,为他们发声,诉说着他们生存的苦痛与乡愁。从城市到农村间的游走带来的是身与心的疼痛和对家的无限思念。 展开更多
关键词 打工诗歌 生存 苦痛 乡愁
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