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MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression 预览
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作者 Bridget Martinez Philip V.Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期606-619,共14页
Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years... Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years;however,it can occur in young children and much older adults.Factors identified in the distribution of MS include age,gender,genetics,environment,and ethnic background.Multiple sclerosis is usually associated with progressive degrees of disability.The disease involves demyelination of axons of the central nervous system and causes brain and spinal cord neuronal loss and atrophy.Diagnosing multiple sclerosis is based on a patient’s medical history including symptoms,physical examination,and various tests such as magnetic resonance imaging,cerebrospinal fluid and blood tests,and electrophysiology.The disease course of multiple sclerosis is not well correlated with the biomarkers presently used in clinical practice.Blood-derived biomarkers that can detect and distinguish the different phenotypes in multiple sclerosis may be advantageous in personalized treatment with disease-modifying drugs and to predict response to treatment.The studies reviewed have shown that the expression levels of a large number of miRNAs in peripheral blood,serum,exosomes isolated from serum,and cerebrospinal fluid are altered in multiple sclerosis and can distinguish the disease phenotypes from each other.Further studies are warranted to independently validate these findings so that individual or pairs of miRNAs in serum or cerebrospinal fluid can be used as potential diagnostic markers for adult and pediatric multiple sclerosis and for monitoring disease progression and response to therapy. 展开更多
关键词 clinically isolated syndrome CSF disease PROGRESSION EXOSOMES humans microRNA multiple SCLEROSIS PERIPHERAL blood PHENOTYPES serum
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基于超高效液相色谱-质谱联用技术研究婴儿巨细胞病毒肝炎证候实质
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作者 李维薇 杨燕 +6 位作者 戴启刚 徐珊 单进军 谢彤 林丽丽 贺丽丽 汪受传 《中华中医药杂志》 CAS CSCD 北大核心 2019年第5期1881-1887,共7页
目的:从尿液代谢组学层面探讨婴儿巨细胞病毒(HCMV)肝炎患儿湿热内蕴证、脾虚湿困证、气滞血瘀证的证候实质。方法:收集HCMV肝炎湿热内蕴证(44例)、脾虚湿困证(35例)、气滞血瘀证(43例)、正常对照组(40名)患儿,进行生化指标统计分析,同... 目的:从尿液代谢组学层面探讨婴儿巨细胞病毒(HCMV)肝炎患儿湿热内蕴证、脾虚湿困证、气滞血瘀证的证候实质。方法:收集HCMV肝炎湿热内蕴证(44例)、脾虚湿困证(35例)、气滞血瘀证(43例)、正常对照组(40名)患儿,进行生化指标统计分析,同时采用超高效液相色谱-质谱联用技术,对患儿尿液样本进行代谢组学检测,经主成分分析寻找各证型的生物标志物。结果:在生化指标分析中,各证型组在丙氨酸氨基转移酶、门冬氨酸氨基转移酶、总胆红素、结合胆红素、总胆汁酸、谷氨酰转肽酶、碱性磷酸酶、乳酸脱氢酶及凝血酶原时间水平有显著差异。在代谢组学研究中,各证型组在正交偏最小二乘法-判别分析图上区分明显。各证型组均涉及氨基酸代谢紊乱。此外,各证型均有特征性生物标志物。结论:HCMV肝炎湿热内蕴证、脾虚湿困证及气滞血瘀证在生化指标和尿液代谢物水平均存在显著差异,表明不同中医证候有其生物学基础。 展开更多
关键词 婴儿巨细胞病毒肝炎 证候 代谢组学 湿热内蕴证 脾虚湿困证 气滞血瘀证
尘肺病中医证候和证素分布规律的文献研究 预览 被引量:1
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作者 谢洋 赵虎雷 +1 位作者 王佳佳 李建生 《中医学报》 CAS 2019年第5期1117-1120,共4页
目的:基于文献分析探讨尘肺病中医证候要素的分布规律。方法:从中国知网、中国生物医学文献数据库、万方数据库和维普网数据库中检索相关文献,并对文献信息进行收集整理,采用SPSS 20.0统计学软件包进行统计描述的分析。结果:频率较高的... 目的:基于文献分析探讨尘肺病中医证候要素的分布规律。方法:从中国知网、中国生物医学文献数据库、万方数据库和维普网数据库中检索相关文献,并对文献信息进行收集整理,采用SPSS 20.0统计学软件包进行统计描述的分析。结果:频率较高的证型依次为燥邪伤肺证(8.28%)、肺阴虚证(7.64%)、肺气虚证(7.64%)、肺脾气虚证(7.01%)和痰湿阻肺证(7.01%)。构成尘肺病的中医证候要素有20个,病性证素中以气虚(30.57%)、阴虚(24.20%)和痰(21.66%)为主,病位证素中以肺(63.69%)为主;在证素组合中,以两证素和三证素组合最常见,累计频率为(89.18%)。单一病性证素中,气虚、阴虚和燥邪出现的频率较高,其频率分别为34.88%、18.60%和15.12%;两病性组合时,气虚+阴虚、痰+湿、痰+瘀和痰+热出现的频率较高,其频率分别为28.57%、17.46%、14.29%和9.52%。结论:尘肺病的主要病理因素以燥邪、气虚、阴虚和痰为主,病位主要在肺。 展开更多
关键词 尘肺 证候 病位证素 病性证素 文献研究
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鼻咽癌前病变证候、证素、证型调查表的研制及评价 预览
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作者 王贤文 田道法 +1 位作者 朱镇华 胡革 《湖南中医药大学学报》 CAS 2019年第9期1129-1132,共4页
目的探索鼻咽癌前病变规范化的四诊信息采集方案,并以此为基础建立鼻咽癌前病变四诊信息采集的相关标准。方法在文献调查研究、专家组讨论基础上,筛选出与鼻咽癌前病变相关的证候、证素及证型,然后参照国际通用调查表的设计,研制出鼻咽... 目的探索鼻咽癌前病变规范化的四诊信息采集方案,并以此为基础建立鼻咽癌前病变四诊信息采集的相关标准。方法在文献调查研究、专家组讨论基础上,筛选出与鼻咽癌前病变相关的证候、证素及证型,然后参照国际通用调查表的设计,研制出鼻咽癌前病变证候、证素、证型调查表,并对该表的信度和效度进行检测。结果研制出了鼻咽癌前病变证候、证素、证型调查表,对其信度和效度进行了检验,结果显示:调查表具备良好的内部一致性信度和重测信度,内容符合中医理论及临床实际,具备较好的真实性和可靠性。结论鼻咽癌前病变证候、证素、证型调查表具备较好的信度与效度,基本达到鼻咽癌前病变中医四诊信息采集规范化的目的。在规范采集四诊信息的基础上,再结合运用证素计量辨证法,应能有效提升中医药防治鼻咽癌前病变的整体水平。 展开更多
关键词 鼻咽癌前病变 证候 证素 证型 调查表
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Contribution of ghrelin to functional gastrointestinal disorders’pathogenesis 预览
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作者 Tilemachos Koutouratsas Theodora Kalli +1 位作者 Georgios Karamanolis Maria Gazouli 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期539-551,共13页
Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology re... Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology remains obscure and,although it is expected to differ according to the specific FGID,disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis.The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions,including regulation of gastrointestinal motility and protection of mucosal tissue.Ghrelin’s gene shows genetic polymorphism,while its protein product undergoes complex regulation and metabolism in the human body.Numerous studies have studied ghrelin’s relation to the emergence of FGIDs,its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment.Despite the mixed results currently available in scientific literature,the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis.The aim of this paper is to review current literature studying these associations,in an effort to uncover certain patterns of alterations in both genetics and expression,which could delineate its true contribution to FGID emergence,either as a causative agent or as a pathogenetic intermediate. 展开更多
关键词 FUNCTIONAL GASTROINTESTINAL disorders FUNCTIONAL colonic diseases Irritable bowel SYNDROME Cyclic VOMITING SYNDROME Infantile COLIC GASTROINTESTINAL disease GHRELIN Genetics Epigenetic processes
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Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients
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作者 ZHAO Hai-ping LIU Ping +3 位作者 XU Chang-min LI Guang-wen GAO Li LUO Yu-min 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第8期590-597,共8页
Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two s... Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two syndrome types in acute ischemic stroke patients. Methods: A microarray assay was performed to assess the expression pattern of miRNAs in the lymphocyte of acute ischemic stroke patients. Target genes for the deregulated miRNAs were predicated using the online bioinformatic algorithms and functional annotation via Kyoto encyclopedia of genes and genomes pathway analysis for miRNAs predicted targets was carried out. Based on the predicted target genes of differentially expressed miRNAs, the miRNA-gene-network and miRNA-pathway network were constructed. Results: Yang score based on tongue texture, urine, dejecta, and appearance, etc. showed that clinical symptoms were distinct between yang and yin syndromes. There were significantly higher total leukocyte number and lower total protein level in patients with yang syndrome compared with those in patients with yin syndrome (P<0.05). Comprehensive miRNA analysis identified 36 unique down-regulated miRNAs in yang syndrome group, and 20 unique down-regulated and 2 unique up-regulated miRNAs in yin syndrome group. The key regulatory miRNAs, gene, and pathways in the yang syndrome were hsa-miR-93-5p and -320b, enabled homolog, the metabolic pathways and mitogen-activated protein kinase signaling pathways, respectively, while those in the yin syndrome were hsa-miR-424-5p and -106b-5p, CNOT4, hepatitis B and pathways in cancer, respectively. Conclusion: These results offered insight into the molecular basis underlying the different pathogenesis of yang or yin syndrome, providing clues for the individualized therapeutic strategies of acute ischemic stroke. 展开更多
关键词 acute ISCHEMIC stroke yang SYNDROME YIN SYNDROME MICRORNAS profile diagnosis Chinese medicine
短期大剂量氢化可的松诱发小鼠药源性证候的评价研究
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作者 李亚 潘志强 +1 位作者 钱宏梁 方肇勤 《上海中医药大学学报》 CAS 2019年第2期55-60,65共7页
目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·... 目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·kg^-1·d^-1组),每组8只。氢化可的松不同剂量组小鼠分别灌胃给予相应浓度的氢化可的松溶液,对照组小鼠灌胃给予相同体积灭菌水,连续5 d。分别于给药第1、3、5天称量每只小鼠体质量。末次给药后,采用课题组前期建立的小鼠辨证论治实验方法学检测小鼠表征信息(躯体不同部位红外温度、腋温、抓力);取各只小鼠胸腺、脾脏称重,计算脏器指数;分离肾上腺组织,实时荧光定量PCR技术检测类固醇激素合成酶(Star、Cyp11a1、Cyp21a1、Cyp11b1)基因表达,Western blot检测StAR、SRBI与LDLR蛋白表达。结果:①给药1、3、5 d后,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组小鼠的体质量均较对照组显著降低(P<0.05,P<0.01)。②给药5 d后,氢化可的松12.5 mg·kg^-1·d^-1和25 mg·kg^-1·d^-1组小鼠的头部最高温度均较对照组显著降低(P<0.05),但氢化可的松各剂量组小鼠的躯干平均温度、尾部最低温度、腋温、抓力无明显变化。③与对照组相比,氢化可的松各剂量组小鼠的脾脏指数均明显下降(P<0.01),且呈剂量依赖性;50 mg·kg^-1·d^-1组小鼠的胸腺指数较对照组显著降低(P<0.01)。④与对照组相比,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组肾上腺组织中Star、Cyp11a1、Cyp11b1和Cyp21a1的mRNA表达均显著减少(P<0.05,P<0.01),StAR、LDLR和SRBI蛋白表达均显著降低(P<0.05,P<0.01)。结论:大剂量氢化可的松(25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1)短期给药5 d可显著抑制小鼠肾上腺皮质功能,其证候表现以药源性阴虚证为主。 展开更多
关键词 氢化可的松 肾上腺皮质 证候 阴虚证 小鼠
甲状腺功能亢进症中医证候学调查
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作者 孙科 高天舒 《实用中医内科杂志》 2019年第9期1-3,共3页
[目的]因甲状腺功能亢进症(以下简称甲亢)发病率增高,严重影响人们的正常生活,研究甲亢的证候学特点,为甲亢的辨证处方提供直接数据支持。[方法]我们于2011年3月-2011年10月在辽宁中医药大学附属医院内分泌科门诊进行临床流行病学调查,... [目的]因甲状腺功能亢进症(以下简称甲亢)发病率增高,严重影响人们的正常生活,研究甲亢的证候学特点,为甲亢的辨证处方提供直接数据支持。[方法]我们于2011年3月-2011年10月在辽宁中医药大学附属医院内分泌科门诊进行临床流行病学调查,按照自愿如实的原则,通过问卷调查的方式记录101例确诊为甲亢的患者的症状、体征及脉象,使用数码相机拍摄患者舌象,汇总以上材料,由两名主任中医师确认甲亢患者的证候。[结果]①常见症状按频率依次为:烦躁、心悸、手震颤、乏力、消瘦、甲状腺肿大等。②舌象特点:舌质最多的是舌质鲜红,58(58%);舌苔最多的是少苔,73(73%)。③脉象最多的是脉弦数,45(45%);④辩证分型:甲亢的证候按出现频率依次为肝肾阴虚证、心肝火旺证、脾虚湿盛证、脾肾阳虚证、痰火内扰证。FT4> 4倍正常值上限的这组中,肝肾阴虚证最多,占总数的44%。正常值上限<FT4 <4倍正常值上限这组中,肝肾阴虚证最多,占总数的60%。[结论]中药治疗甲亢应以滋补肝肾之阴为主,佐以疏肝、化痰及活血之品,为中医辨证用药治疗甲亢在证候学方面提供直接数据支持。 展开更多
关键词 甲状腺功能亢进症 证候 相火 肝肾阴虚证
Novel mutation in OCRL leading to a severe form of Lowe syndrome
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作者 Feng-Qi Zhou Qi-Wei Wang +5 位作者 Zhen-Zhen Liu Xu-Lin Zhang Dong-Ni Wang Mei-Mei Dongye Hao-Tian Lin Wei-Rong Chen 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1057-1060,共4页
AIM: To investigate the phenotype and genotype of a family with X-linked recessive Lowe syndrome. METHODS: All the members in the Chinese pedigree underwent comprehensive ophthalmologic and systemic examinations. Geno... AIM: To investigate the phenotype and genotype of a family with X-linked recessive Lowe syndrome. METHODS: All the members in the Chinese pedigree underwent comprehensive ophthalmologic and systemic examinations. Genomic DNA was isolated from peripheral blood of the pedigree members and 100 unrelated healthy Chinese subjects. Direct sequencing was performed to screen the exons and intron boundaries of OCRL.RESULTS: The ophthalmological and systemic exami nations suggested that the affected individual had Lowe syndrome. The phenotype in the pedigree is severe and consistent among all the affected individuals except for an individual who additionally suffered from congenital heart disease and laryngeal cartilage dysplasia. Directio nal San ger sequenci ng identified a complex mutation c.(2368_2368delG;c.2370A>C) in the Rho-GTPase activating protein domain. This complex mutation causes termination of protein synthesis at amino acid 824 and result in a new peptide with 823 amino acids (p.Ala790ProfsX34). This mutation was not detected in 100 unrelated healthy Chinese subjects.CONCLUSION: Our findings expand the phenotypic and genotypic spectrum of Lowe syndrome. 展开更多
关键词 LOWE SYNDROME oculocerebrorenal SYNDROME OCRL CONGENITAL MEMBRANOUS CATARACT
A review of Behcet’s disease from the perspectives of both Western and Chinese Medicine
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作者 Zhang Jing Tang Yuping +5 位作者 Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期139-148,共10页
Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characte... Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet’s disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East.This article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet’s disease. Furthermore, the etiology of Behcet’s disease will be evaluated from the aspect of Traditional Chinese Medicine(TCM) syndrome differentiation. As Behcet’s disease is complex and intractable, its treatment warrants further research.Traditionally, Behcet’s disease is treated with Western Medicine(WM) via medications that act locally and systemically;this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet’s disease via a combination of WM and TCM.Recent studies have indicated that such a combination of Chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet’s disease, and to outline its possible pathogenesis in terms of both TCM and WM. Based on these findings, the present review proposes a Behcet’s disease treatment protocol composed of a combination of Chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication. 展开更多
关键词 Behcet SYNDROME SYNDROME differentiation treatment VIRULENCE RECURRENCE THERAPEUTICS Review
糖尿病证候研究思路与方法的现状及展望 预览
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作者 石白 倪青 《环球中医药》 CAS 2019年第8期1281-1286,共6页
随着现代科学的发展,证候的相关研究取得了更深次的进展,同时临床研究也表明它正在影响着中医学的规范化与现代化。证候的相关研究主要是指对证候要素的研究,常见的研究类型有文献研究、专家问卷和临床试验等;常见的研究方法有聚类分析... 随着现代科学的发展,证候的相关研究取得了更深次的进展,同时临床研究也表明它正在影响着中医学的规范化与现代化。证候的相关研究主要是指对证候要素的研究,常见的研究类型有文献研究、专家问卷和临床试验等;常见的研究方法有聚类分析、因子分析、决策树、人工神经网络、Logistic回归分析、随机森林法等。与此同时,为了适应科研和临床需要,已有许多专家在糖尿病证候诊断规范方面提供了相关研究方法与思路,如建立证候动物模型,建立证候量化诊断标准,将证候客观化和微观化,病证结合与统一等方法,在糖尿病证候演变规律方面常采用横断面调查、回顾性研究、前瞻性研究等方法,从而使得对糖尿病证候研究做到客观化、微观化、定量化,对糖尿病诊疗做到病证结合,方证统一。 展开更多
关键词 糖尿病 证候 方法与思路 聚类分析 病证结合
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A rare case of non-ST-segment elevation myocardial infarction triggered by coronary subclavian steal syndrome 预览
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作者 Xiao-Qing CAI Feng TIAN +7 位作者 Shan-Shan ZHOU Jing JING Wei HU Tao ZHANG Xi WANG Ri-Na DU Qiang XU Yun-Dai CHEN 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第4期378-380,共3页
Coronary subclavian steal syndrome (CSSS) has been recognized lately as an unusual clinical entity,giving rise to angina but rarely causing an acute coronary syndrome (ACS). The prerequisites for the appearance of CSS... Coronary subclavian steal syndrome (CSSS) has been recognized lately as an unusual clinical entity,giving rise to angina but rarely causing an acute coronary syndrome (ACS). The prerequisites for the appearance of CSSS are both a patent left internal mammary artery (LIMA) graft and severe stenosis of the left subclavian artery (LSA). However,LSA is often overlooked in the diagnostic evaluation of patients with angina,who have underwent coronary artery bypass grafting (CABG). We report an unusual case of non-ST-segment elevation myocardial infarction (NSTEMI) caused by subtotal occlusion of proximal LSA. 展开更多
关键词 Acute CORONARY SYNDROME CORONARY artery BYPASS GRAFTING CORONARY SUBCLAVIAN steal SYNDROME PERCUTANEOUS CORONARY intervention
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基于名医名家临证经验的前列腺增生症中医证候、证素分布文献分析
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作者 吴梦婷 王停 +3 位作者 刘珊 陈聪 范琼尹 苏泽琦 《中国实验方剂学杂志》 CAS CSCD 北大核心 2019年第20期173-180,共8页
目的:基于名医名家临证经验,明确前列腺增生症(BPH)证候类型及证候要素分布规律,以期为指导临床实践及科学研究提供依据。方法:确定名医名家名单,系统检索1997年1月1日至2018年12月31日,中国知网(CNKI),中国生物医学文献服务系统(CBM)... 目的:基于名医名家临证经验,明确前列腺增生症(BPH)证候类型及证候要素分布规律,以期为指导临床实践及科学研究提供依据。方法:确定名医名家名单,系统检索1997年1月1日至2018年12月31日,中国知网(CNKI),中国生物医学文献服务系统(CBM)、重庆维普中文期刊数据库(QVIP)、万方数据库中名医名家诊治BPH相关文献,根据纳入标准及排除标准,对检索的相关文献阅读后,纳入合格文献。建立文献分析数据库,分析、整合中医证候及证候要素相关内容,应用SPSS 20. 0软件进行统计,获得BPH中医证候类型及证候要素分布特点。结果:该研究共纳入合格文献141篇,涉及92位名医名家,结合医家对BPH整体论述及医案列举,得到BPH常见证候类型为肾虚血瘀证、膀胱湿热证、肾阴虚证、肾阳虚证、肝郁气滞证等;病位证素主要为肾、膀胱、脾、肺、肝;病性证素主要为血瘀、气虚、热、阳虚、湿等。对医案中症状特点进行归纳整理,得到BPH常见症状为尿频、尿滴沥、尿急、夜尿增多、排尿困难等;舌质以淡红、红、暗红、瘀斑瘀点为主;舌苔以黄腻、薄白、薄黄、白腻为主;脉象以沉细、细涩、弦脉、弦滑为主。结论:该研究基于名医名家临证经验,得出BPH病位在下焦,主要责之肾与膀胱,核心病机总属本虚标实,肾虚为本,瘀血、湿热、痰浊、气滞为标,且以复合证型多见。 展开更多
关键词 前列腺增生 证候 证候要素 文献研究
Chemical screen identifies a geroprotective role of quercetin in premature aging
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作者 Lingling Geng Zunpeng Liu +12 位作者 Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2019年第6期417-435,共19页
Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for ge... Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. 展开更多
关键词 QUERCETIN STEM cell AGING Werner SYNDROME Hutchinson-Gilford progeria SYNDROME
慢性非萎缩性胃炎与慢性萎缩性胃炎证候、证素分布规律文献研究
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作者 黄远程 黄超原 +3 位作者 梁怀枫 潘静琳 李培武 刘凤斌 《中医杂志》 CSCD 北大核心 2019年第16期1417-1422,共6页
目的探讨慢性非萎缩性胃炎(CNAG)与慢性萎缩性胃炎(CAG)的证候、证素分布规律及差异。方法检索中国生物医学文献数据库、中国知网全文数据库、万方数据库和重庆维普中文期刊数据库,纳入有关CNAG、CAG证候的流行病学调查研究及中医临床... 目的探讨慢性非萎缩性胃炎(CNAG)与慢性萎缩性胃炎(CAG)的证候、证素分布规律及差异。方法检索中国生物医学文献数据库、中国知网全文数据库、万方数据库和重庆维普中文期刊数据库,纳入有关CNAG、CAG证候的流行病学调查研究及中医临床辨证分型治疗研究。收集文献的一般资料、病例辨证分型并建立数据库,分别统计CNAG、CAG证候和病性类、病位类证素的频次、病例数以及构成比,并比较二者差异。结果共纳入文献241篇,其中CNAG文献64篇,CAG文献177篇,共计病例数36 315例,其中CNAG病例11535例,CAG病例24780例。CNAG常见证候类型依次为肝胃不和证、脾胃气虚证、脾胃湿热证、脾胃阳虚证、胃阴亏虚证、瘀阻胃络证,CAG常见证候类型依次为肝胃不和证、胃阴亏虚证、脾胃气虚证、脾胃湿热证、脾虚气滞证,其中CNAG肝胃气滞证多于CAG,CAG瘀阻胃络证多于CNAG。CNAG常见病性类证素依次为气虚、热、气滞、湿、阳虚,CAG常见病性类证素依次为气虚、热、阴虚、湿、气滞。其中CNAG气滞、阳虚证素多于CAG,CAG瘀证素多于CNAG (P <0. 05)。CNAG和CAG病位均以胃、脾、肝、肠为主,其中CNAG病位多在胃,CAG病位多在脾(P <0. 05)。结论肝胃不和证和脾胃气虚证为CNAG和CAG的核心证候,其中CNAG病机以胃气滞为显著,CAG病机以脾气虚更为显著。胃阴亏虚、胃络瘀阻是CAG区别于CNAG的主要证候特点。 展开更多
关键词 慢性非萎缩性胃炎 慢性萎缩性胃炎 证候 证素 肝胃不和 脾胃气虚
Symptom frequency and development of a generic functional disorder symptom scale suitable for use in studies of patients with irritable bowel syndrome, fibromyalgia syndrome or chronic fatigue syndrome
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作者 Michael E.Hyland Alison M.Bacon +1 位作者 Joseph W.Lanario Anthony F.Davies 《慢性疾病与转化医学:英文版》 CSCD 2019年第2期129-138,共10页
Objectives: To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom q... Objectives: To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom questionnaire. Methods: A patient-derived 61-item symptom-frequency questionnaire was completed by participants recruited through IBS, FMS and CFS self-help websites. Principal axis factor analysis with oblimin rotation was performed separately for those reporting an IBS, FMS or CFS diagnosis. Results: Questionnaires were completed by 1751 participants of whom 851 reported more than one of the three diagnoses. Stomach pain on at least a weekly basis was reported by 79% of IBS, 52% of FMS, and 43% of CFS single diagnosis participants. Pain increasing the day after activity was reported by 32% of IBS, 94% of FMS, and 85% of CFS single diagnosis participants. Waking still tired at least once weekly was reported by 75% of IBS, 97% of FMS, and 95% of CFS single diagnosis participants. Exploratory factor analysis produced consistent results across all three diagnostic groups, the 61 items loading on 12 correlated factors with a single higher order factor on which all items loaded. Frequency analysis led to the rejection of one item (cold sores on or near lips), and freeform reporting by participants of additional symptoms identified an additional five, namely, restless legs, hair loss/brittle hair/thinning, dizziness/balance problems, blurred vision and urination problems. Conclusions: IBS, FMS and CFS are polysymptomatic spectrum disorders with a wide range of overlapping symptoms, many of which are unrelated to diagnostic criteria. Frequency analysis and factor analysis confirm the validity of using the same questionnaire across different diagnostic categories. The 65-item general symptom questionnaire (GSQ-65) is a valid generic symptom scale suitable for assessing the many different symptoms of people with IBS, FMS and CFS. 展开更多
关键词 Functional DISORDER FIBROMYALGIA IRRITABLE BOWEL SYNDROME Chronic fatigue SYNDROME SYMPTOM measurement
Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis 预览
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作者 Ya-Li Zhang Li-Ting Cai +9 位作者 Jun-Yi Qi Yun-Zheng Lin Yan-Cheng Dai Na Jiao You-Lan Chen Lie Zheng Bei-Bei Wang Li-Xin Zhu Zhi-Peng Tang Rui-Xin Zhu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第25期3242-3255,共14页
BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndrome... BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostr 展开更多
关键词 ULCERATIVE colitis Intestinal MICROBIOTA Pi-Xu-Shi-Yun SYNDROME Da-Chang-Shi-Re SYNDROME Traditional Chinese medicine
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Syndrome differentiation of Zang-Fu for Tourette syndrome in children 预览
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作者 Zhao Mu Teng Huang Zhan-Ling Zhang 《TMR整合医学》 2019年第13期1-8,共8页
As a kind of psychoneurotic disease, the incidence of Tourette syndrome (TS) is increasing graduaLy in recent years. Modern medicine for the pathogenesis of this disease has not been cteary in the treatment is mainty ... As a kind of psychoneurotic disease, the incidence of Tourette syndrome (TS) is increasing graduaLy in recent years. Modern medicine for the pathogenesis of this disease has not been cteary in the treatment is mainty symptomatic treatment. Based on syndrome differentiation and treatment traditional medicine treats the unique system of etiotogy and pathogenesis of the disease, and achieves remarkable results in treatment. Chinese medicine treatment of children's diseases generaLy from the viscera diatecticaL In this paper, we summarize the ctinicat experience of the treatment of pediatric TS by syndrome differentiation of viscera in order to provide reference for the ctinicat treatment and research of pediatric TS. 展开更多
关键词 TOURETTE SYNDROME TCMy SYNDROME DIFFERENTIATION REVIEW
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基于1205例文献病例的发作性睡病中医证候及证候要素研究
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作者 郎奕 冯淬灵 +2 位作者 白文 戴中 杨嘉颐 《时珍国医国药》 CAS CSCD 北大核心 2019年第3期754-755,共2页
目的探讨发作性睡病证候及证候要素的分布规律。方法对中国期刊全文数据库(1979年~2017年)、万方数据库(1990年~2017年)的全部期刊进行检索,对符合要求的发作性睡病证候进行规范,提取证候要素,原始数据用EpiData 2.0建立数据库,运用SPSS... 目的探讨发作性睡病证候及证候要素的分布规律。方法对中国期刊全文数据库(1979年~2017年)、万方数据库(1990年~2017年)的全部期刊进行检索,对符合要求的发作性睡病证候进行规范,提取证候要素,原始数据用EpiData 2.0建立数据库,运用SPSS 13.0进行频数、构成比统计。结果共纳入73篇文献,1205例发作性睡病患者,发作性睡病最常见的证候依次是肝郁气滞证369例(30.62%),风痰扰神证315例(26.14%),脾虚湿困证297例(24.65%);提取病性类证候要素15个,最常见的依次为痰519例(43.07%),气虚518例(42.99%),湿404例(33.53%),气滞377例(31.29%),动风369例(30.62%);病位类证候要素10个,最常见的依次为脾652例(54.11%),肝386例(32.03%),脑315例(26.14%)。结论基于文献的发作性睡病证候及证候要素研究,初步反映了本病的证候及证候要素分布规律,可为进一步确定发作性睡病的中医辨证分型标准提供参考和依据。 展开更多
关键词 发作性睡病 证候 证候要素 文献研究
Spectrum of gastrointestinal involvement in Stevens-Johnson syndrome 预览
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作者 Ashish Kumar Jha Arya Suchismita +1 位作者 Rajeev Kumar Jha Vikas Kumar Raj 《世界胃肠内镜杂志:英文版(电子版)》 2019年第2期115-123,共9页
Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus ... Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus membrane lesions usually involve the oral cavity,lips,bulbar conjunctiva and the anogenitalia.The oral/anal mucosa and liver are commonly involved in SJS or TEN.However,intestinal involvement is distinctly rare.We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN.This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN. 展开更多
关键词 STEVENS-JOHNSON SYNDROME TOXIC EPIDERMAL necrolysis Lyell’s SYNDROME Gastrointestinal involvement COLON ILEUM
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