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巴菲特的Alpha
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作者 安德里亚·弗拉兹尼 大卫·卡比勒 +1 位作者 拉斯·哈杰·佩德森 许娜(编译) 《金融市场研究》 2019年第4期120-129,共10页
本文通过分析和汇编股票收益、共同基金数据、持股数据、SEC报告以及手工收集的有关伯克希尔-哈撒韦年报的评论,试图揭开伯克希尔-哈撒韦投资组合表现优异之谜。文章认为,沃伦·巴菲特的成功不是靠运气或魔力,而是他选择低价、安全... 本文通过分析和汇编股票收益、共同基金数据、持股数据、SEC报告以及手工收集的有关伯克希尔-哈撒韦年报的评论,试图揭开伯克希尔-哈撒韦投资组合表现优异之谜。文章认为,沃伦·巴菲特的成功不是靠运气或魔力,而是他选择低价、安全、优质股所带来的回报。 展开更多
关键词 巴菲特 ALPHA 投资策略
基于2DAlphaShapes自动生成露天矿台阶爆破边界 预览
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作者 崔年生 《采矿技术》 2019年第2期138-141,共4页
为了实现三维可视化环境下露天矿台阶爆破边界的自动生成,首次将2DAlphaShapes算法应用于爆破边界轮廓线的提取中。先将实测炮孔数据的孔口坐标转化为平面炮孔点,再依据爆破缓冲距离和爆破方向对炮孔点进行偏移,得到炮孔偏移点,最后通过... 为了实现三维可视化环境下露天矿台阶爆破边界的自动生成,首次将2DAlphaShapes算法应用于爆破边界轮廓线的提取中。先将实测炮孔数据的孔口坐标转化为平面炮孔点,再依据爆破缓冲距离和爆破方向对炮孔点进行偏移,得到炮孔偏移点,最后通过2DAlphaShapes算法提取炮孔点和炮孔偏移点的外围轮廓线,生成露天台阶爆破边界。实践结果表明:该方法简洁高效,运行稳定,提取精度高,适用于任何形状的爆破区域边界轮廓线提取。 展开更多
关键词 露天矿 爆破设计 爆破边界提取 2D ALPHA SHAPES
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Ginsenoside Rbl Upregulating AQP5 Protein Expression and Alleviating Salivary Secretion Impairment in Ovariectomized SjOgren's Syndrome Mice
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作者 HE Xi YANG Liu +4 位作者 LIU Xintong WEI Wei SHI Ce LI Baoquan LI Jiang 《高等学校化学研究:英文版》 SCIE CAS CSCD 2019年第3期418-426,共9页
Sjogren's syndrome(SS) is an autoimmune disease characterized as the impairment of salivary secretion mediated by abnormal aquaporin 5(AQP5). Here we used AQP5 promoter as the target to screen the eflective compon... Sjogren's syndrome(SS) is an autoimmune disease characterized as the impairment of salivary secretion mediated by abnormal aquaporin 5(AQP5). Here we used AQP5 promoter as the target to screen the eflective components from natural drugs. Panax quinquefolius and its specific ingredient, Rbl, were identified to increase the AQP5 transcriptional activity and AQP5 expression. Then we investigated the possibility of Rbl binding to sex hormone receptors and demonstrated that Rbl bound specifically to estrogen receptor alpha(ERa), but not to androgen receptor. Next, we found that ERa overexpression magnified the effect of Rbl induced AQP5 transcription, and the silence of ERa blocked this effect, demonstrating that Rbl activated AQP5 transcription via ERa pathway. Importantly, we constructed SS mouse model and investigated the effects of Rbl on salivary secretion in vivo. SS mice exhibited significant impairment in salivary secretion and decreased AQP5 expression in the submandibular gland. Intriguingly, SS mice administered with Rbl exhibited dramatically increased salivary secretion, followed by decreased diary water consumption. In particular, Rbl up-regulated AQP5 expression localized in the submandibular gland, almost similar to the SS mice administered with estrogen. Our data demonstrated that Rbl bound with ERa to up-regulate AQP5 to increase saliva secretion, thus functioned as a potential natural phytoestrogen for the therapy of salivary secretion impairment in SS patients. 展开更多
关键词 Sjogren's syndrome AQUAPORIN 5 Estrogen receptor alpha GINSENOSIDE RBL SUBMANDIBULAR gland
Xijiao Dihuang Decoction(犀角地黄汤)and Rehmannia glutinosa Libosch.Protect Mice against Lipopolysaccharide and Tumor Necrosis Factor Alpha-Induced Acute Liver Failure
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作者 LIU Yan-min ZHU Liu-luan +5 位作者 LI Rui ZHANG Jin-liang YAO Shan-shan ZHOU Xiao-bing ZENG Hui WANG Xian-bo 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第6期446-453,共8页
Objective: To investigate the hepatoprotective effect of Xijiao Dihuang Decoction(犀角地黄汤,XJDHD) on lipopolysaccharide(LPS)-and tumor necrosis factor alpha(TNF-α)-induced acute liver failure(ALF)as well as the und... Objective: To investigate the hepatoprotective effect of Xijiao Dihuang Decoction(犀角地黄汤,XJDHD) on lipopolysaccharide(LPS)-and tumor necrosis factor alpha(TNF-α)-induced acute liver failure(ALF)as well as the underlying mechanism of action, and to clarify the key herbs and components of XJDHD. Methods:LPS/D-galactosamine(D-GalN) or TNF-α/D-GalN were intraperitoneally injected into C57BL/6J mice to induce ALF. Simultaneously, XJDHD or its individual herbs and components were orally administered. Survival rates, transaminase levels in serum, and hepatic histology were examined to evaluate the effects of XJDHD.The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) assay and real-time polymerase chain reaction were additionally performed to expound the mechanism underlying the anti-apoptotic activity of XJDHD. Results: Oral administration of XJDHD protected mice from lethal liver failure induced by LPS and TNF-α, with notable amelioration of liver injury in histology and a significant decrease in transaminase levels in serum. XJDHD signi?cantly inhibited apoptosis of hepatocytes and enhanced expression of the antiapoptosis genes, c-Flip, Iap1, Gadd45 b and A20(all P<0.05). In addition, Rehmannia glutinosa Libosch. was identi?ed as the key herb of XJDHD and galactose as the effective component of Rehmannia glutinosa Libosch.that protects against ALF. Conclusions: XJDHD inhibits TNF-α-induced apoptosis of hepatocytes by promoting the expression of nuclear factor κB-regulated anti-apoptotic genes. Rehmannia glutinosa Libosch. may be the most effective herb of XJDHD and galactose is an active component in this protection. 展开更多
关键词 Xijiao Dihuang DECOCTION Chinese medicine REHMANNIA glutinosa Libosch. acute liver failure LIPOPOLYSACCHARIDES tumor NECROSIS factor alpha
AlphaZero:一种人类从未见过的智慧 预览
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作者 Demis Hassabis 晗冰(编译) 《科学中国人》 2019年第2期74-75,共2页
在围棋上打败天下无敌手之后,DeepMind旗下的Alpha家族开始深入探究所有棋类,其中就包括国际象棋、日本将军棋。2018年12月初,在Alpha Zero诞生一周年之际,《自然》杂志以封面文章发布了AlphaZero经过同行审议的完整论文,Deepmind创始人... 在围棋上打败天下无敌手之后,DeepMind旗下的Alpha家族开始深入探究所有棋类,其中就包括国际象棋、日本将军棋。2018年12月初,在Alpha Zero诞生一周年之际,《自然》杂志以封面文章发布了AlphaZero经过同行审议的完整论文,Deepmind创始人兼CEO哈萨比斯亲自执笔了这一论文。 展开更多
关键词 ALPHA 智慧 人类 《自然》杂志 国际象棋 封面文章 围棋 CEO
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Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer
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作者 Liang-Yu Bie Dan Li +15 位作者 Yu Mu Sheng Wang Bei-Bei Chen Hui-Fang Lyu Li-Li Han Cai-Yun Nie Chang-Cheng Yang Lin Wang Chuan-Chuan Ren Wei-Jie Zhang Ping Guo Feng Shi Qing-Xia Fan Liu-Xing Wang Xiao-Bing Chen Su-Xia Luo 《慢性疾病与转化医学:英文版》 CSCD 2019年第1期44-52,共9页
Objective: To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment. Methods: The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencin... Objective: To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment. Methods: The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencing data were used to predict genes co-expressed with cyclin E. Co-expression genes predicted by cBioPortal online analysis with Pearson correlation coefficient ≥0.4 were analyzed by gene ontology (GO) enrichment annotation using the PANTHER online platform (Ver. 7). Interactions between proteins encoded by these genes were analyzed using the STRING online platform (Ver. 10.5) and Cytoscape software (Ver. 3.5.1). Genes displaying a high degree of connection were analyzed by transcription factor enrichment prediction using FunRich software (Ver. 3). The significant transcription factor and cyclin E expression levels and their impact on gastric cancer progression were analyzed by Western blotting and Kaplan-Meier survival curve analysis. Results: After filtering the co-expression gene prediction results, 78 predicted genes that included 73 protein coding genes and 5 non-coding genes with Pearson correlation coefficient ≥0.4 were selected. The expressions of the genes were considered to be correlated with cyclin E expression. Among the 78 genes co-expressed with cyclin E, 19 genes at the central of the regulatory network associated with cyclin E were discovered. Nuclear transcription factor Y subunit alpha (NF-YA) was identified as a significant transcription factor associated with cyclin E co-expressing genes. Analysis of specimen donors’ clinical records revealed that high expression of NF-YA tended to be associated with increased cyclin E expression. The expression of both was associated with progression of gastric cancer. Western blotting results showed that compared with normal tissues, NF-YA and cyclin E were highly expressed in tumor tissues (P < 0.001). Survival curve analysis clearly demonstrated relatively poor overall survival of gastric cancer patients with high cyclin E or high NF-YA ex 展开更多
关键词 Cyclin E NUCLEAR transcription factor Y SUBUNIT alpha ONCOGENE Gastric cancer
PLZF^posc-KIT^pos-delineated A1-A4-differentiating spermatogonia by subset and stage detection upon Bouin fixation
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作者 Rui-Ling Tang Li-Qing Fan 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期309-318,共10页
While hallmarks of rodent spermatogonia stem cell biomarkers' heterogeneity have recently been identified, their stage and subset distributions remain unclear. Furthermore, it is currently difficult to accurately ... While hallmarks of rodent spermatogonia stem cell biomarkers' heterogeneity have recently been identified, their stage and subset distributions remain unclear. Furthermore, it is currently difficult to accurately identify subset-specific SSC marker distributions due to the poor nuclear morphological characteristics associated with fixation in 4% paraformaldehyde. In the present study, testicular cross-sections and whole-mount samples were Bouin fixed to optimize nuclear resolution and visualized by immunohistochemistry (IHC) and immunofluorescence (IF). The results identified an expression pattern of PLZFhighc-KITpos in A1 spermatogonia, while A2–A4-differentiating spermatogonia were PLZFlowc-KITpos. Additionally, this procedure was used to examine asymmetrically expressing GFRA1 and PLZF clones, asymmetric Apr and false clones were distinguished based on the presence or absence of TEX14, a molecular maker of intercellular bridges, despite having identical nuclear morphology and intercellular distances that were <25 μm. In conclusion, this optimized Bouin fixation procedure facilitates the accurate identification of spermatogonium subsets based on their molecular profiles and is capable of distinguishing asymmetric and false clones. Therefore, the findings presented herein will facilitate further morphological and functional analysis studies and provide further insight into spermatogonium subtypes. 展开更多
关键词 asymmetric division cellular homolog of FELINE sarcoma viral oncogene v-kit false CLONES glial CELL line-derived neurotrophic factor receptor alpha 1 PROMYELOCYTIC leukemia zinc finger SPERMATOGONIA stem CELL
Expression of visual system homeobox 1 in human keratoconus
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作者 Ya-Ni Wang Xian-Ning Liu +5 位作者 Xiao-Dong Wang Yong Yin Yan Chen Xiang-Hua Xiao Kun Xu Xiu-Ping Zhu 《国际眼科杂志:英文版》 SCIE CAS 2019年第2期201-206,共6页
AIM:To investigate the expression of visual system homeobox 1(VSX1)and myofibroblast marker alpha smooth muscle actin(α-SMA)in keratoconus(KC).METHODS:Thirty corneal tissue were collected from KC patients after corne... AIM:To investigate the expression of visual system homeobox 1(VSX1)and myofibroblast marker alpha smooth muscle actin(α-SMA)in keratoconus(KC).METHODS:Thirty corneal tissue were collected from KC patients after corneal transplantation and 15 normal donor corneas were obtained.All corneal tissues divided into 4 parts for different detections.Scanning electron microscopy was used to observe the ultrastructure of the specimens.VSX1 andα-SMA localization in cornea tissues was detected using immunofluorescence histochemistry.Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and Western blot were performed to analyze the expression level of VSX1 andα-SMA.RESULTS:Compared to normal cornea tissue,the collagen fibers in KC stroma were distortional and attenuated and keratocytes were abnormally changed.VSX1 andα-SMA located in the corneal stroma.The mRNA and protein expression level of VSX1 in KC were about 3 times as high as that of normal tissue(P<0.001).α-SMA was hardly expressed in the normal corneas,however,its expression in the KC was about 1.5 times higher than that of the normal corneas(P<0.0001). 展开更多
关键词 visual system HOMEOBOX 1 KERATOCONUS alpha SMOOTH MUSCLE ACTIN KERATOCYTES
HIV-1衣壳蛋白抑制剂体外筛选方法研究进展 预览
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作者 张大为 许晓双 常珊 《中国药理学通报》 CAS CSCD 北大核心 2019年第4期473-477,共5页
HIV-1的感染高度依赖其圆锥形的“富勒烯”型衣壳。衣壳由大约1500个衣壳蛋白组装而成。近年来,衣壳蛋白已成为设计和筛选抗HIV-1药物的理想靶点。目前,文献已报道了多种基于不同原理的HIV-1衣壳蛋白抑制剂的筛选方法,该文将对这些体外... HIV-1的感染高度依赖其圆锥形的“富勒烯”型衣壳。衣壳由大约1500个衣壳蛋白组装而成。近年来,衣壳蛋白已成为设计和筛选抗HIV-1药物的理想靶点。目前,文献已报道了多种基于不同原理的HIV-1衣壳蛋白抑制剂的筛选方法,该文将对这些体外筛选方法进行综述。 展开更多
关键词 HIV-1 衣壳蛋白抑制剂 邻近闪烁分析 均相时间分辨荧光 放大化学发光临近均相检测 噬菌体展示 双分子荧光互补 假病毒 虚拟筛选
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摆脱束缚的跨平台利器HyperX Cloud Mix游戏耳机 预览
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作者 马宇川(文/图) 《微型计算机》 2019年第7期62-64,共3页
在2018年,金士顿旗下电竞品牌HyperX曾发布了一款特别的游戏耳机—HyperX Cloud Alpha。它以特别的双音腔设计、突出定位的能力得到了游戏玩家的关注。而如今为了让玩家能更方便地体验双音腔技术带来的好处,并在PC、手机等不同平台上应... 在2018年,金士顿旗下电竞品牌HyperX曾发布了一款特别的游戏耳机—HyperX Cloud Alpha。它以特别的双音腔设计、突出定位的能力得到了游戏玩家的关注。而如今为了让玩家能更方便地体验双音腔技术带来的好处,并在PC、手机等不同平台上应用,HyperX特别于近期推出了不仅拥有有线连接能力,还可轻松“变形”为蓝牙游戏耳机的HyperX Cloud Mix天际。那么它能带来哪些不一样的体验? 展开更多
关键词 游戏耳机 MIX 跨平台 Alpha 游戏玩家 有线连接 金士顿 腔设计
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腕机屏幕背后的故事柔性显示企业维信诺或将引领下一次的智能手机革命 预览
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《新潮电子》 2019年第5期86-87,共2页
智能穿戴行业最近一个月提振士气的大事件莫过于Nubia Alpha腕机,之所以弓|人关注,是因为它以一个手表的形态,打造出一款真正戴在手腕上的手机。要知道,即使苹果Apple Watch,由于屏幕太小,也只能作为iPhone的一个接入端而已。Nubia Alph... 智能穿戴行业最近一个月提振士气的大事件莫过于Nubia Alpha腕机,之所以弓|人关注,是因为它以一个手表的形态,打造出一款真正戴在手腕上的手机。要知道,即使苹果Apple Watch,由于屏幕太小,也只能作为iPhone的一个接入端而已。Nubia Alpha腕机之所以被视为未来手机的发展方向,是因为它有一块契合手腕弧度的柔性AMOLED屏幕,环绕在手腕上的显示面积均可以作为交互之用。 展开更多
关键词 OLED屏幕 智能手机 柔性显示 ALPHA 企业 iPhone 显示面积 手腕
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Two-year delay in ulcerative colitis diagnosis is associated with antitumor necrosis factor alpha use 预览
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作者 Ho Suk Kang Ja-Seol Koo +5 位作者 Kang Moon Lee Dae-Bum Kim Ji Min Lee Yoon Jae Kim Hyuk Yoon Hyun Joo Jang 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第8期989-1001,共13页
BACKGROUND Ulcerative colitis(UC)is an uncommon inflammatory bowel disease(IBD).However,its incidence has recently increased in South Korea.Moreover,UC diagnoses are frequently delayed,and the relationship between dia... BACKGROUND Ulcerative colitis(UC)is an uncommon inflammatory bowel disease(IBD).However,its incidence has recently increased in South Korea.Moreover,UC diagnoses are frequently delayed,and the relationship between diagnostic delay and UC prognosis has not been extensively studied in South Korean patients.AIM To identify meaningful diagnostic delay affecting UC prognosis and to evaluate risk factors associated with diagnostic delay in South Korean patients.METHODS Medical records of 718 patients with UC who visited the outpatient clinic of six university hospitals in South Korea were reviewed;167 cases were excluded because the first symptom date was unknown.We evaluated the relationship between the prognosis and a diagnostic delay of 3,6,12,18,and 24 mo by comparing the prognostic factors[anti-tumor necrosis factor(TNF)-αuse,admission history due to acute flare-ups,frequent admission due to flare-ups,surgery associated with UC,and the clinical remission state at the latest followup]at each diagnostic interval.RESULTS The mean diagnostic interval was 223.3±483.2 d(median,69 d;75th percentile,195 d).Among the prognostic factors,anti-TNFαuse was significantly increased after a diagnostic delay of 24 mo.Clinical risk factors predictive of a 24-mo diagnostic delay were age<60 years at diagnosis[odd ratio(OR)=14.778,95%confidence interval(CI):1.731-126.121],smoking history(OR=2.688,95%CI:1.239-5.747,P=0.012),and misdiagnosis of hemorrhoids(OR=11.066,95%CI:3.596-34.053).Anti-TNFαuse was associated with extensive UC at diagnosis(OR=3.768,95%CI:1.860-7.632)and 24-mo diagnostic delay(OR=2.599,95%CI:1.006-4.916).CONCLUSION A diagnostic delay>24 mo was associated with increased anti-TNFαuse.Age<60 years at diagnosis,smoking history,and misdiagnosis of hemorrhoids were risk factors for delayed diagnosis. 展开更多
关键词 ULCERATIVE colitis Diagnostic DELAY ANTI-TUMOR NECROSIS factor alpha SMOKING
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Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved 预览
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作者 Raquel Coronel Charlotte Palmer +4 位作者 Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1661-1671,共11页
The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of AP... The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. 展开更多
关键词 AMYLOID precursor protein APP SOLUBLE APP alpha SOLUBLE APP BETA AMYLOID BETA peptide APP intracellular domain NEURAL stem CELLS NEURAL progenitor CELLS neurogenesis signaling pathways
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百度Alpha学院让AI碰撞产业,让大咖遇见大咖
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作者 石嫣然 石珊珊 《培训》 2019年第5期50-58,共9页
AI时代,未来已来。对百度来说,让未来变得更加清晰的方式之一也许是:走出去,和产业融合创新。在未来充满不确定的情况下,认知升级的速度决定了产业智能化的速度与质量,百度Alpha学院建立的初衷正是如此。
关键词 ALPHA 产业 百度 AI 学院 碰撞 融合创新 智能化
Effects of AOS on Bt’s Adhesion Amount on Vegetable Leaves and Its Insecticidal Effect 预览
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作者 Airan CHEN Yinghao MA Dayong JIN 《农业生物技术:英文版》 CAS 2019年第2期235-237,共3页
[Objectives] This study was conducted to investigate the safety of surfactants AOS and Tween 80 on Bt and their effects on Bt’s adhesion amount on crop leaves and its field efficacy.[Methods] Certain concentrations o... [Objectives] This study was conducted to investigate the safety of surfactants AOS and Tween 80 on Bt and their effects on Bt’s adhesion amount on crop leaves and its field efficacy.[Methods] Certain concentrations of AOS and Tween 80 were added to Bt liquid to check the effects of the surfactants on Bt spore germination, the adhesion amount of Bt on vegetable leaves and the field efficacy on beet armyworm.[Results] After treatment with surfactants AOS and Tween 80, Bt spores germinated normally. After adding AOS, the adhesion amounts of Bt spores on scallion, kohlrabi, radish and Chinese cabbage leaves were 209.75, 249.00, 274.00 and 281.75, respectively, which was 3.8, 2.2, 2.0 and 1.6 times higher than the CK. After adding Tween 80, the adhesion amounts of Bt spores on scallion, kohlrabi, radish and Chinese cabbage leaves were 198.25, 203.25, 233.00 and 236.75, respectively, which were 3.6, 1.8, 1.7 and 1.4 times higher than the CK, respectively. The average field insecticidal effect of the Bt liquid reached 81.3% and 79.5% after the addition of surfactants AOS and Tween 80, respectively, while the average insecticidal effect of the CK without the addition of a surfactant was only 53.3%, which was remarkably lower than above two values.[Conclusions] Surfactants AOS and Tween 80 are safe for Bt;and the addition of surfactants AOS and Tween 80 significantly increased the amount of Bt attached to vegetable leaves, and significantly improved the control efficacy of pests on plants rich in cuticle. 展开更多
关键词 Bacillus THURINGIENSIS Surfactant Alpha olefine SULFONATE ADHESION AMOUNT Control efficacy
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A New Calculation of Rotational Bands in Alpha-Cluster Nuclei
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作者 N.Roshanbakht M.R.Shojaei 《理论物理通讯:英文版》 SCIE CAS CSCD 2018年第7期67-70,共4页
关键词 轻原子核 ALPHA 旋转 计算 ALPHA 相对运动 粒子
基于ALPHA语言的复杂查询SQL语句生成 预览
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作者 汪洋 《安庆师范大学学报:自然科学版》 2018年第4期123-125,共3页
用SQL语言表达复杂查询,是数据库教学中的一个重点和难点,但对数据库理论的初学者是个挑战。文章提出了一个复杂查询的SQL语句生成框架,首先将复杂查询用ALPHA语言表示,然后利用逻辑谓词等价变换理论,将ALPHA语句中的全称量词和逻辑蕴... 用SQL语言表达复杂查询,是数据库教学中的一个重点和难点,但对数据库理论的初学者是个挑战。文章提出了一个复杂查询的SQL语句生成框架,首先将复杂查询用ALPHA语言表示,然后利用逻辑谓词等价变换理论,将ALPHA语句中的全称量词和逻辑蕴含进行等价变换,再使用ALPHA语言向SQL语言变换生成算法生成SQL查询。该框架在多年的教学实践中得到了检验,并取得了较好的教学效果。 展开更多
关键词 数据库 复杂查询 ALPHA SQL 谓词等价变换
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Influence of Sodium Carbonate Amount on Crystalline Phase and Structure Stability for Doping Nickel Hydroxide
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作者 赵腾起 朱燕娟 +3 位作者 LI Wenhua FENG Zuyong ZHANG Wei JIAN Xiuwen 《武汉理工大学学报:材料科学英文版》 SCIE EI CAS 2018年第3期552-558,共7页
关键词 镍氢氧化物 结构稳定性 碳酸盐 水晶 ALPHA ALPHA 阶段转变
Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer 预览
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作者 Angeles C Tecalco-Cruz JosuéO Ramírez-Jarquín 《世界临床肿瘤学杂志》 2018年第4期60-70,共11页
Estrogen receptor alpha(ERα)is detected in more than 70%of the cases of breast cancer.Nuclear activity of ERα,a transcriptional regulator,is linked to the development of mammary tumors,whereas the extranuclear activ... Estrogen receptor alpha(ERα)is detected in more than 70%of the cases of breast cancer.Nuclear activity of ERα,a transcriptional regulator,is linked to the development of mammary tumors,whereas the extranuclear activity of ERαis related to endocrine therapy resistance.ERαpolyubiquitination is induced by the estradiol hormone,and also by selective estrogen receptor degraders,resulting in ERαdegradation via the ubiquitin proteasome system.Moreover,polyubiquitination is related to the ERαtranscription cycle,and some E3-ubiquitin ligases also function as coactivators for ERα.Several studies have demonstrated that ERαpolyubiquitination is inhibited by multiple mechanisms that include posttranslational modifica-tions,interactions with coregulators,and formation of specific protein complexes with ERα.These events are responsible for an increase in ERαprotein levels and deregulation of its signaling in breast cancers.Thus,ERαpolyubiquitination inhibition may be a key factor in the progression of breast cancer and resistance to endocrine therapy. 展开更多
关键词 ESTROGEN RECEPTOR ALPHA POLYUBIQUITINATION BREAST cancer ESTROGEN RECEPTOR ALPHA
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Selection and evaluation of potential reference genes for gene expression analysis in greenbug (Schizaphis graminum Rondani) 预览
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作者 ZHANG Bai-zhong LIU Jun-jie +2 位作者 YUAN Guo-hui CHEN Xi-ling GAO Xi-wu 《农业科学学报:英文版》 SCIE CAS CSCD 2018年第9期2054-2065,共12页
关键词 基因表达式 评估 聚合酶链反应 药剂处理 精确估计 目标基因 ALPHA 28S
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