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Kinematic and Dynamic Analysis of a 3-■US Spatial Parallel Manipulator 认领
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作者 Mervin Joe Thomas M.L.Joy A.P.Sudheer 《中国机械工程学报:英文版》 SCIE EI CAS CSCD 2020年第1期114-130,共17页
Parallel Kinematic Machines(PKMs)are being widely used for precise applications to achieve complex motions and variable poses for the end effector tool.PKMs are found in medical,assembly and manufacturing industries w... Parallel Kinematic Machines(PKMs)are being widely used for precise applications to achieve complex motions and variable poses for the end effector tool.PKMs are found in medical,assembly and manufacturing industries where accuracy is necessary.It is often desired to have a compact and simple architecture for the robotic mechanism.In this paper,the kinematic and dynamic analysis of a novel 3-PRUS(P:prismatic joint,R:revolute joint,U:universal joint,S:spherical joint)parallel manipulator with a mobile platform having 6 Degree of Freedom(Do F)is explained.The kinematic equations for the proposed spatial parallel mechanism are formulated using the Modified Denavit-Hartenberg(DH)technique considering both active and passive joints.The kinematic equations are used to derive the Jacobian matrix of the mechanism to identify the singular points within the workspace.A Jacobian based sti ness analysis is done to understand the variations in sti ness for different poses of the mobile platform and further,it is used to decide trajectories for the end effector within the singularity free region.The analytical model of the robot dynamics is presented using the Euler-Lagrangian approach with Lagrangian multipliers to include the system constraints.The gravity and inertial forces of all links are considered in the mathematical model.The analytical results of the dynamic model are compared with ADAMS simulation results for a pre-defined trajectory of the end effector. 展开更多
关键词 Parallel manipulator Kinematic MODELLING WORKSPACE ANALYSIS Euler-Lagrangian MODELLING SINGULARITY ANALYSIS Stiffness ANALYSIS
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Comparing different domains of analysis for the characterisation of N-glycans on monoclonal antibodies 认领
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作者 Sara Carillo Raquel Perez-Robles +5 位作者 Craig Jakes Meire Ribeiro da Silva Silvia Millan Martín Amy Farrell Natalia Navas Jonathan Bones 《药物分析学报:英文版》 SCIE CAS CSCD 2020年第1期23-34,共12页
With the size of the biopharmaceutical market exponentially increasing,there is an aligned growth in the importance of data-rich analyses,not only to assess drug product safety but also to assist drug development driv... With the size of the biopharmaceutical market exponentially increasing,there is an aligned growth in the importance of data-rich analyses,not only to assess drug product safety but also to assist drug development driven by the deeper understanding of structure/function relationships.In monoclonal antibodies,many functions are regulated by N-glycans present in the constant region of the heavy chains and their mechanisms of action are not completely known.The importance of their function focuses analytical research efforts on the development of robust,accurate and fast methods to support drug development and quality control.Released N-glycan analysis is considered as the gold standard for glycosylation characterisation;however,it is not the only method for quantitative analysis of glycoform heterogeneity.In this study,ten different analytical workflows for N-glycan analysis were compared using four monoclonal antibodies.While observing good comparability between the quantitative results generated,it was possible to appreciate the advantages and disadvantages of each technique and to summarise all the observations to guide the choice of the most appropriate analytical workflow according to application and the desired depth of data generated. 展开更多
关键词 N-GLYCANS Biopharmaceuticals MONOCLONAL ANTIBODIES Intact MASS ANALYSIS MASS SPECTROMETRY Native MASS SPECTROMETRY Glycan ANALYSIS Peptide mapping Glycopeptide ANALYSIS
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Thermo-structural analysis of regenerative cooling thrust chamber cylinder segment based on experimental data 认领
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作者 Di LIU Bing SUN +2 位作者 Taiping WANG Jiawen SONG Jianwei ZHANG 《中国航空学报:英文版》 SCIE EI CAS CSCD 2020年第1期102-115,共14页
To evaluate the structural failure risk of the regenerative cooling thrust chamber cylinder segment,a Finite Element Method(FEM)based on experimental data was developed.The methodology was validated and utilized to re... To evaluate the structural failure risk of the regenerative cooling thrust chamber cylinder segment,a Finite Element Method(FEM)based on experimental data was developed.The methodology was validated and utilized to reveal the thermal response and the nonlinear deformation behavior of the cylinder segment phase by phase.The conclusions of the research are as follows:The 2 D heat flux distribution caused by the injector determines the uneven temperature distribution on the gas-side wall and leads to the temperature disparity between various cooling channels;The reason for the accumulation of residual strain is that the tensile strain generated in the post-cooling phase is greater than the compressive strain produced in the hot run phase;Through the single-cycle simulation,two potential failure locations with conspicuous deformations were found,but it is difficult to determine which point is more dangerous.However,the multi-cycle thermo-structural analysis gives the evolution of the stress-strain curve and gradually discloses that the low-temperature corner of a particular channel is the most likely location to fail,rather than the maximum residual strain point of the gas-side wall.The damage analysis for dangerous point indicates that the quasistatic damage accounts for the majority of the total damage and is the main factor limiting the service life. 展开更多
关键词 Finite element ANALYSIS ROCKET engine REGENERATIVE cooling Structural ANALYSIS THRUST CHAMBER Thermal ANALYSIS
Combination of sensitivity and uncertainty analyses for sediment transport modeling in sewer pipes 认领
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作者 Isa Ebtehaj Hossein Bonakdari +7 位作者 Mir Jafar Sadegh Safari Bahram Gharabaghi Amir Hossein Zaji Hossien Riahi Madavar Zohreh Sheikh Khozani Mohammad Sadegh Es-haghi Aydin Shishegaran Ali Danandeh Mehr 《国际泥沙研究:英文版》 SCIE 2020年第2期157-170,共14页
Mitigation of sediment deposition in lined open channels is an essential issue in hydraulic engineering practice.Hence,the limiting velocity should be determined to keep the channel bottom clean from sediment deposits... Mitigation of sediment deposition in lined open channels is an essential issue in hydraulic engineering practice.Hence,the limiting velocity should be determined to keep the channel bottom clean from sediment deposits.Recently,sediment transport modeling using various artificial intelligence(AI)techniques has attracted the interest of many researchers.The current integrated study highlights unique insight for modeling of sediment transport in sewer and urban drainage systems.A novel methodology based on the combination of sensitivity and uncertainty analyses with a machine learning technique is proposed as a tool for selection of the best input combination for modeling process at non-deposition conditions of sediment transport.Utilizing one to seven dimensionless parameters,127 models are developed in the current study.In order to evaluate the different parameter combinations and select the training and testing data,four strategies are considered.Considering the densimetric Froude number(Fr)as the dependent parameter,a model with independent parameters of volumetric sediment concentration(CV)and relative particle size(d/R)gave the best results with a mean absolute relative error(MARE)of 0.1 and a root means square error(RMSE)of 0.67.Uncertainty analysis is applied with a machine learning technique to investigate the credibility of the proposed methods.The percentage of the observed sample data bracketed by 95%predicted uncertainty bound(95PPU)is computed to assess the uncertainty of the best models. 展开更多
关键词 Non-deposition SEDIMENT transport Sensitivity ANALYSIS SEWER UNCERTAINTY ANALYSIS Urban drainage
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Modal Analysis and Multi-objective Optimization of Pressurizing Pipeline 认领
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作者 王野平 李杭 《东华大学学报:英文版》 EI CAS 2020年第1期43-49,共7页
The pressurizing pipeline of hot press resonates under the excitation load,which poses a serious hidden danger to the safety of the equipment and the operator.In order to increase the natural frequency of the pressuri... The pressurizing pipeline of hot press resonates under the excitation load,which poses a serious hidden danger to the safety of the equipment and the operator.In order to increase the natural frequency of the pressurizing pipeline,modal analysis of the pressurizing pipeline is carried out to study the mechanism of pipeline vibration and common vibration reduction measures.A method of increasing the natural frequency of the pressurizing pipeline was analyzed.The influence of pipeline clamp assembly stiffness,pipeline clamp number and pipeline clamp installation position on the mode of the pressurizing pipeline is studied.Sensitivity analysis is carried out to study the influence of the various parameters on the mode of the pressurizing pipeline.Genetic algorithm based on Pareto optimality is introduced for multi-objective optimization of pressurizing pipeline.The optimization results show that the natural frequency of the pressurizing pipeline increases by 2.4%and the displacement response is reduced by 17.7%. 展开更多
关键词 pressurizing PIPELINE MODAL ANALYSIS sensitivity ANALYSIS PARETO OPTIMALITY genetic algorithm MULTI-OBJECTIVE optimization
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Novel Primate Bocaparvovirus Species 3 Identified in Wild Macaca Mulatta in China 认领
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作者 Yuanyun Ao Zhaojun Duan 《中国病毒学:英文版》 SCIE CAS CSCD 2020年第1期34-42,共9页
Primate bocaparvovirus(BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a gro... Primate bocaparvovirus(BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates(NHPs). Here, we report the identification of a novel BOV(provisionally named Macaca mulatta bocaparvovirus [MmBOV]) in the feces of wild Macaca mulatta in China by viral metagenomic analysis. Seven of 400 fecal samples from Macaca mulatta were positive for MmBOV. An almost complete genome sequence of 4,831 nucleotides was obtained, which had genomic organization and protein motifs similar to human bocaviruses(HOBVs), and shared characteristically low G/C content and weak codon usage bias. Sequence analyses of NS1, NP1, and VP1 revealed that Mm BOV was most closely related to HBOV4 of Primate bocaparvovirus 2(approximately 68.4%/70.6%, 73.3%/67.6%, and 70.4%/73.1% nucleotide/amino acid identities, respectively). Additionally, phylogenetic analysis revealed that Mm BOV formed an independent peripheral branch, but clustered closely with those of the Primate bocaparvovirus species in the BOV genus(particularly HBOV4). These data strongly suggest that HBOV4 originated from NHP bocaparvoviruses around 200–300 years ago, and that NHPs may act as HBOV reservoirs. Following the International Committee of Taxonomy for Viruses guidelines, we propose Mm BOV as a new species(tentatively named Primate bocaparvovirus 3) in the genus Bocaparvovirus, which is the first report of a novel species of primate BOV. Our data facilitate future research on the genetic diversity and evolution of primate bocaparvoviruses and highlight the importance of bocaparvovirus surveys in wild NHPs. 展开更多
关键词 Primate bocaparvovirus(BOV) Novel species Macaca mulatta Sequence analysis Phylogenetic analysis
Evaluation of Temporal Changes in Deep Well Water Quality in Igabi Local Government Area of Kaduna State 认领
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作者 John Jiya Musa Otuaro Ebierni Akpoebidimiyen +2 位作者 Mohammed Tanimu Musa Pius Olusegun Olufemi Dada Elijah Tsado Musa 《环境保护(英文)》 2020年第1期22-33,共12页
The research work was carried out in Igabi Local Government of Kaduna State. Thirty water samples from boreholes were randomly collected within the major towns in November to April (Dry), and May to October (Rainy sea... The research work was carried out in Igabi Local Government of Kaduna State. Thirty water samples from boreholes were randomly collected within the major towns in November to April (Dry), and May to October (Rainy season). The samples were analyzed for physical, chemical, and bacteriological parameters and to observe any changes in the groundwater quality of the area. Analysis of variance (ANOVA), Pearson Correlation were performed on the data obtained using SPSS 10.0 for a window for significant variations and inter-element relationship. High mean turbidity was recorded in boreholes in Danfili (12.2 NTU), Kwarau (6.2 NTU). Mean turbidity of 4.3 NTU was recorded in Dry season for wells with Rigachikun having 5.1 NTU. It was observed that a negative correlation exists between well depth and heavy metal concentration. There was also a linear relationship of 0.686 between well distance and nitrate (faecal contaminant). Mean value for Fluoride (0.22 mg/l), Sodium (20.78 mg/l), Calcium (15.7 mg/l), Iron (0.013 mg/l), Nitrate (3.69 mg/l), Cadmium (0.00102 mg/l) Chloride (22.107 mg/l) recorded for sampled wells were all within WHO standard. A high value of 24 mg/l and 25 mg/l for Nitrate was recorded in Saminaka Road and Danfili. An indication of contamination during the rainy season indicates surface-groundwater intrusion (influx). The results of the bacteriological analysis indicated that most wells sampled have a range of 1 cfu/100 ml to 7 cfu/100 ml with Danfili Mani having the highest value (7 cfu/100 ml) which make it unsaved (not Potable). 展开更多
关键词 TEMPORAL CHANGE Analysis GROUNDWATER Physiochemical Bacteriological Quality
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A Note on Laplace Transforms of Some Common Distributions Used in Counting Processes Analysis 认领
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作者 Eugene Kouassi Edouard Akpata Koffi Pokou 《应用数学(英文)》 2020年第2期67-75,共9页
An important problem of actuarial risk management is the calculation of the probability of ruin. Using probability theory and the definition of the Laplace transform one obtains expressions, in the classical risk mode... An important problem of actuarial risk management is the calculation of the probability of ruin. Using probability theory and the definition of the Laplace transform one obtains expressions, in the classical risk model, for survival probabilities in a finite time horizon. Then explicit solutions are found with the inversion of the double Laplace transform;using algebra, the Laplace complex inversion formula and Matlab, for the exponential claim amount distribution. 展开更多
关键词 LAPLACE Transforms COMMON DISTRIBUTIONS ANALYSIS PROBABILITY DISTRIBUTIONS COUNTING Processes
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Geotechnical forensic investigation of a slope failure on silty clay soil--A case study 认领
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作者 Mohammad Abubakar NAVEED Zulfiqar ALI +3 位作者 Abdul QADIR Umar Naveed LATIF Saad HAMID Umar SARWAR 《结构与土木工程前沿:英文版》 SCIE EI CSCD 2020年第2期501-517,共17页
Qila Bala Hisar is one of the noteworthy places of Peshawar,Khyber Pakhtunkhwa.The fort was constructed on a flled ground during the 18th century and it was renovated several times by the occupants ever since.Recently... Qila Bala Hisar is one of the noteworthy places of Peshawar,Khyber Pakhtunkhwa.The fort was constructed on a flled ground during the 18th century and it was renovated several times by the occupants ever since.Recently,due to an earthquake of magnitude 7.3,the upper part of the south-western wall of the fort collapsed.The collapse of the wall was attributed to the failure of the retained slope.This research was undertaken to characterize the slope material,study causal factors of failure and evaluate remedial strategy.The investigation involved conventional field and laboratory testing and geophysical investigation using electrical resistivity technique to evaluate the nature of stratum.Also,X-ray Diffraction and Scanning Electron Microscopy was used to study the slope material at a molecular level to evaluate the existence of swelling potential.The analysis has shown that excessive seepage of water caused by the poor maintenance of runoff and sewage drains is the causal factor triggered by the seismic event.A remedial strategy involving soil nails,micro piles and improvement of the surface drainage is recommended. 展开更多
关键词 forensic geotechnical investigation slope failure slope analysis finite element method numerical analysis seismic loading Qila Bala Hisar
Understanding roof deformation mechanics and parametric sensitivities of coal mine entries using the discrete element method 认领
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作者 Rami Abousleiman Gabriel Walton Sankhaneel Sinha 《矿业科学技术学报:英文版》 SCIE EI CSCD 2020年第1期123-129,共7页
Although conventional coal mine designs are conservative regarding pillar strength,local failures such as roof-falls and pillar bursts still affect mine safety and operations.Previous studies have identified that disc... Although conventional coal mine designs are conservative regarding pillar strength,local failures such as roof-falls and pillar bursts still affect mine safety and operations.Previous studies have identified that discontinuous,layered roof materials have some self-supporting capacity.This research is a preliminary step towards understanding these mechanics in coal-measure rocks.Although others have considered broad conceptual models and simplified analogs for mine roof behavior,this study presents a unique numerical model that more completely represents in-situ roof conditions.The discrete element method(DEM)is utilized to conduct a parametric analysis considering a range of in-situ stress ratios,material properties,and joint networks to determine the parameters controlling the stability of single-entries modeled in two-dimensions.Model results are compared to empirical observations of roof-support effectiveness(ARBS)in the context of the coal mine roof rating(CMRR)system.Results such as immediate roof displacement,overall stability,and statistical relationships between model parameters and outcomes are presented herein.Potential practical applications of this line of research include:(1)roof-support optimization for a range of coal-measure rocks,(2)establishment of a relationship between roof stability and pillar stress,and(3)determination of which parameters are most critical to roof stability and therefore require concentrated evaluation. 展开更多
关键词 Numerical modeling DISCRETE element method Coal mine ROOF rating ANALYSIS of ROOF bolt systems Sensitivity ANALYSIS Strain softening UBIQUITOUS joints DISCRETE fracture network
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Stability and weighted sensitivity analysis of robust controller for heat exchanger 认领
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作者 Sapna GUPTA Rajeev GUPTA Subhransu PADHEE 《控制理论与技术:英文版》 EI CSCD 2020年第1期56-71,共16页
This study presents a parametric system identification approach to estimate the dynamics of a chemical plant from experimental data and develops a robust PID controller for the plant.Parametric system identification o... This study presents a parametric system identification approach to estimate the dynamics of a chemical plant from experimental data and develops a robust PID controller for the plant.Parametric system identification of the heat exchanger system has been carried out using experimental data and prediction error method.The estimated model of the heat exchanger system is a time-delay model and a robust PID controller for the time-delayed model has been designed considering weighted sensitivity criteria.The mathematical background of parametric system identification,stability analysis,and H∞ weighted sensitivity analysis have been provided in this paper.A graphical plot has been provided to determine the stability region in the(Kp,Ki),(Kp,Kd)and(KuKd)plane.The stability region is a locus dependent on parameters of the controller and frequency,in the parameter plane. 展开更多
关键词 Heat exchanger parametric system identification prediction error method PID controller robust stability analysis weighted sensitivity analysis
Estimation of drift limits for different seismic damage states of RC frame staging in elevated water tanks using Park and Ang damage index 认领
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作者 Suraj O.Lakhade Ratnesh Kumar O.R.Jaiswal 《地震工程与工程振动:英文版》 SCIE EI CSCD 2020年第1期161-177,共17页
Damage to elevated water tanks in past earthquakes can be attributed to the poor performance of their supporting frame staging. In order to ascertain the performance of these elevated water tanks, it is crucial to cat... Damage to elevated water tanks in past earthquakes can be attributed to the poor performance of their supporting frame staging. In order to ascertain the performance of these elevated water tanks, it is crucial to categorize the damage in quantifiable damage states. Among various parameters to quantify the damage states, the top drift of frame staging can be conveniently correlated to the different damage levels. In literature, drift limits corresponding to different damage states of the frame staging of the elevated water tank are not available. In the present study, drift limits for RC frame staging in elevated water tanks corresponding to different seismic damage states have been proposed. Various damage states of the elevated water tank have been determined using the Park and Ang damage index. The Park and Ang damage index utilizes results of both pushover analysis and incremental dynamic analysis. Twelve models of elevated water tanks have been developed considering variation in staging height and tank capacity. Incremental dynamic analysis has been performed using the suite of twelve actual earthquake ground motions. Based on the regression analysis between damage indexes and drift, limiting drift values for each damage state are proposed. 展开更多
关键词 ELEVATED water tank frame STAGING damage states DRIFT limit 3D modelling INCREMENTAL dynamic ANALYSIS PUSHOVER ANALYSIS
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Compiler testing: a systematic literature analysis 认领
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作者 Yixuan TANG Zhilei REN +1 位作者 Weiqiang KONG He JIANG 《中国计算机科学前沿:英文版》 SCIE EI CSCD 2020年第1期1-20,共20页
Compilers are widely-used infrastructures in accelerating the software development,and expected to be trustworthy.In the literature,various testing technologies have been proposed to guarantee the quality of compilers... Compilers are widely-used infrastructures in accelerating the software development,and expected to be trustworthy.In the literature,various testing technologies have been proposed to guarantee the quality of compilers.However,there remains an obstacle to comprehensively characterize and understand compiler testing.To overcome this obstacle,we propose a literature analysis framework to gain insights into the compiler testing area.First,we perform an extensive search to construct a dataset related to compiler testing papers.Then,we conduct a bibliometric analysis to analyze the productive authors,the influential papers,and the frequently tested compilers based on our dataset.Finally,we utilize association rules and collaboration networks to mine the authorships and the communities of interests among researchers and keywords.Some valuable results are reported.We find that the USA is the leading country that contains the most influential researchers and institutions.The most active keyword is“random testing”.We also find that most researchers have broad interests within small-scale collaborators in the compiler testing area. 展开更多
关键词 software engineering compiler-theory and techniques literature analysis collaboration network bibliometric analysis
Sequencing analysis of matrix metalloproteinase 7-induced genetic changes in Schwann cells 认领
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作者 Pan-Jian Lu Gang Wang +2 位作者 Xiao-Dong Cai Ping Zhang Hong-Kui Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第11期2116-2122,共7页
Previous research revealed the positive activity of matrix metalloproteinase 7(MMP7) on migration and myelin regeneration of Schwa nn cells(SCs). However, understanding of the molecular changes and biological activiti... Previous research revealed the positive activity of matrix metalloproteinase 7(MMP7) on migration and myelin regeneration of Schwa nn cells(SCs). However, understanding of the molecular changes and biological activities induced by increased amounts of MMP7 in SCs remains limited. To better understand the underlying molecular events, primary SCs were isolated from the sciatic nerve stump of newborn rats and cultured with 10 nM human MMP7 for 24 hours. The results of genetic testing were analyzed at a relatively relaxed threshold value(fold change ≥ 1.5 and P-value < 0.05). Upon MMP7 exposure, 149 genes were found to be upregulated in SCs, whereas 133 genes were downregulated. Gene Ontology analysis suggested that many differentially expressed molecules were related to cellular processes, single-organism processes, and metabolic processes. Kyoto Enrichment of Genes and Genomes pathway analysis further indicated the critical involvement of cell signaling and metabolism in MMP7-induced molecular regulation of SCs. Results of Ingenuity Pathway Analysis(IPA) also revealed that MMP7 regulates biological processes, molecular functions, cellular components, diseases and functions, biosynthesis, material metabolism, cell movement, and axon guidance. The outcomes of further analysis will deepen our comprehension of MMP7-induced biological changes in SCs. This study was approved by the Laboratory Animal Ethics Committee of Nantong University, China(approval No. 20190225-004) on February 27, 2019. 展开更多
关键词 BIOINFORMATIC ANALYSIS INGENUITY pathway ANALYSIS matrix METALLOPROTEINASE 7 peripheral NERVE regeneration RNA sequencing Schwann cells SCIATIC NERVE injury
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Seismic and stress qualification of LMFR fuel rod and simple method for the determination of LBE added mass effect 认领
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作者 M.Khizer Jian-Wei Chen +3 位作者 Guo-Wei Yang Qing-Sheng Wu Yong Song Yong Zhang 《核技术:英文版》 SCIE CAS CSCD 2020年第1期42-56,共15页
In this study, two different designs of liquid metal fast reactor(LMFR) fuel rods wire-wrapped and nonwire-wrapped(bare) are compared with respect to different parameters as a means of considering the optimum fuel des... In this study, two different designs of liquid metal fast reactor(LMFR) fuel rods wire-wrapped and nonwire-wrapped(bare) are compared with respect to different parameters as a means of considering the optimum fuel design. Nuclear seismic rules require that systems and components that are important for safety must be capable of bearing earthquake effects, and that their integrity and functionality should be guaranteed. Mode shapes, natural frequencies, stresses on cladding, and seismic aspects are considered for comparison using ANSYS. Modal analysis is compared in a vacuum and in lead–bismuth eutectic(LBE) using potential flow theory by considering the added mass effect. A simple and accurate approach is suggested for the determination of the LBE added mass effect and is verified by a manually calculated added mass, which further proved the usefulness of potential flow theory for the accurate estimation of the added mass effect. The verification of the hydrodynamic function(τ) over the entire frequency range further validated the finite element method(FEM) modal analysis results. Stresses obtained for fuel rods against different loading combinations revealed that they were within the allowable limits with maximum stress ratios of 0.25(bare) and 0.74(wire-wrapped). In order to verify the structural integrity of cladding tubes, stresses along the cladding length were determined during different transients and were also calculated manually for static pressure. The manual calculations could be roughly compared with the ANSYS results, and the two showed a close agreement. Contact analysis methodology was selected,and the most appropriate analysis options were suggested for establishing contact between the wire and cladding for the wire-wrapped design grid independence analysis,which proved the accuracy of the results, confirmed the selection of the appropriate procedure, and validated the use of the ANSYS mechanical APDL code for LMFR fuel rod analysis. The results provided detailed insight into the structural desi 展开更多
关键词 LMFR FUEL ROD Added mass SEISMIC ANALYSIS Contact ANALYSIS
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Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage 认领
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作者 Liu-Lin Xiong Lu-Lu Xue +7 位作者 Mohammed Al-Hawwas Jin Huang Rui-Ze Niu Ya-Xin Tan Yang Xu Ying-Ying Su Jia Liu Ting-Hua Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期86-95,共10页
A single-nucleotide polymorphism(SNP)is an alteration in one nucleotide in a certain position within a genome.SNPs are associated with disease susceptibility.However,the influences of SNPs on the pathogenesis of neona... A single-nucleotide polymorphism(SNP)is an alteration in one nucleotide in a certain position within a genome.SNPs are associated with disease susceptibility.However,the influences of SNPs on the pathogenesis of neonatal hypoxic-ischemic brain damage remain elusive.Seven-day-old rats were used to establish a hypoxic ischemic encephalopathy model.SNPs and expression profiles of mRNAs were analyzed in hypoxic ischemic encephalopathy model rats using RNA sequencing.Genes exhibiting SNPs associated with hypoxic ischemic encephalopathy were identified and studied by gene ontology and pathway analysis to identify their possible involvement in the disease mechanism.We identified 89 up-regulated genes containing SNPs that were mainly located on chromosome 1 and 2.Gene ontology analysis indicated that the up-regulated genes containing SNPs are mainly involved in angiogenesis,wound healing and glutamatergic synapse and biological processing of calcium-activated chloride channels.Signaling pathway analysis indicated that the differentially expressed genes play a role in glutamatergic synapses,long-term depression and oxytocin signaling.Moreover,intersection analysis of high throughput screening following PubMed retrieval and RNA sequencing for SNPs showed that CSRNP1,DUSP5 and LRRC25 were most relevant to hypoxic ischemic encephalopathy.Significant up-regulation of genes was confirmed by quantitative real-time polymerase chain reaction analysis of oxygen-glucose-deprived human fetal cortical neurons.Our results indicate that CSRNP1,DUSP5 and LRRC25,containing SNPs,may be involved in the pathogenesis of hypoxic ischemic encephalopathy.These findings indicate a novel direction for further hypoxic ischemic encephalopathy research.This animal study was approved on February 5,2017 by the Animal Care and Use Committee of Kunming Medical University,Yunnan Province,China(approval No.kmmu2019038).Cerebral tissue collection from a human fetus was approved on September 30,2015 by the Ethics Committee of Kunming Medical University,Chin 展开更多
关键词 CSRNP1 DUSP5 gene ontology ANALYSIS human FETAL CORTICAL neurons LRRC25 mRNA NEONATAL HYPOXIC ischemic ENCEPHALOPATHY pathogenesis signaling pathway ANALYSIS
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基于超网络的科技论文关键词关联分析 认领
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作者 吴蕾 梁晓贺 宋红燕 《情报学报》 CSSCI CSCD 北大核心 2020年第3期253-258,共6页
科技论文关键词呈现多类型、多关联关系的属性,可以借助具有多层次、多超边的超网络进行表示建模。本研究构建了由研究对象-实验品种-研究用途-技术方法 4层关键词子网和多种关联超边组成的超网络模型,并将该超网络模型用于"农业... 科技论文关键词呈现多类型、多关联关系的属性,可以借助具有多层次、多超边的超网络进行表示建模。本研究构建了由研究对象-实验品种-研究用途-技术方法 4层关键词子网和多种关联超边组成的超网络模型,并将该超网络模型用于"农业动物生殖细胞和干细胞调控"领域的科技论文的实证分析。该超网络模型在揭示单层关键词子网同质关联关系的同时,也能挖掘多层子网之间的隐性异质关联关系,从而发现了该领域常用技术方法、实验品种、研究对象和研究用途,同时还发现了该领域的技术空白点和技术应用空白点,这些空白点很可能成为未来的研究热点。 展开更多
关键词 分析 关联分析 超网络 科技论文
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Uncertainty assessment in hydro-mechanical-coupled analysis of saturated porous medium applying fuzzy finite element method 认领
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作者 Farhoud KALATEH Farideh HOSSEINEJAD 《结构与土木工程前沿:英文版》 SCIE EI CSCD 2020年第2期387-410,共24页
The purpose of the present study was to develop a fuzzy finite element method,for uncertainty quantification of saturated soil properties on dynamic response of porous media,and also to discrete the coupled dynamic eq... The purpose of the present study was to develop a fuzzy finite element method,for uncertainty quantification of saturated soil properties on dynamic response of porous media,and also to discrete the coupled dynamic equations known as u-p hydro-mechanical equations.Input parameters included fuzzy numbers of Poisson's ratio,Young's modulus,and permeability coefficient as uncertain material of soil properties.Triangular membership functions were applied to obtain the intervals of input parameters in five membership grades,followed up by a minute examination of the effects of input parameters uncertainty on dynamic behavior of porous media.Calculations were for the optimized combinations of upper and lower bounds of input parameters to reveal soil response including displacement and pore water pressure via fuzzy numbers.Fuzzy analysis procedure was verified,and several numerical examples were analyzed by the developed method,including a dynamic analysis of elastic soil column and elastic foundation under ramp loading.Results indicated that the range of calculated displacements and pore pressure were dependent upon the number of fuzzy parameters and uncertainty of parameters within equations.Moreover,it was revealed that for the input variations looser sands were more sensitive than dense ones. 展开更多
关键词 fuzzy finite element method saturated soil hydro mechanical coupled equations coupled analysis uncertainty analysis
Parameter study of sinter waste heat recovery in vertical tank based on energy and exergy analysis 认领
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作者 Jun-sheng Feng Sheng Zhang +1 位作者 Hui Dong Gang Pei 《钢铁研究学报:英文版》 SCIE EI CAS CSCD 2020年第1期22-32,共11页
The parameter study of sinter waste heat recovery in vertical tank was conducted numerically by using energy and exergy analysis,and the experimental data obtained from a homemade experimental apparatus was applied to... The parameter study of sinter waste heat recovery in vertical tank was conducted numerically by using energy and exergy analysis,and the experimental data obtained from a homemade experimental apparatus was applied to verify the reliability of numerical model.Based on the first and second laws of thermodynamics,the effects of flow rate of cooling air(FRCA)and inlet temperature of cooling air(ITCA),as well as the inner diameter of cooling section(IDCS)and height of cooling section(HCS),on the sinter cooling process were analyzed in detail.The results show that the average deviation between the experimental data and calculation values is 4.93%,and the model reliability is verified.The enthalpy exergy of outlet air tends to increase first and then decrease with increasing the FRCA and ITCA,while increasing the IDCS only leads to the increase in enthalpy exergy of outlet air.For a given operational condition,the enthalpy exergy of outlet air can reach a maximum value with increasing the HCS.The vertical tank could obtain the maximum enthalpy exergy of outlet air through the adjustments of FRCA and ITCA,as well as the HCS. 展开更多
关键词 SINTER WASTE heat recovery POROUS medium-Energy ANALYSIS EXERGY ANALYSIS Vertical BANK
Effects of Tidal Channels and Roads on Landscape Dynamic Distribution in the Yellow River Delta,China 认领
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作者 YU Xiaojuan ZHANG Zhongsheng +2 位作者 XUE Zhenshan WU Haitao ZHANG Hongri 《中国地理科学:英文版》 SCIE CSCD 2020年第1期170-179,共10页
Landscape characters in estuarine regions generally controlled by tidal regimes and human activities like road construction.In this work,tidal channels and road construction in the Yellow River Delta(YRD)were extracte... Landscape characters in estuarine regions generally controlled by tidal regimes and human activities like road construction.In this work,tidal channels and road construction in the Yellow River Delta(YRD)were extracted by visual interpretation methods so as to decipher impacts of tidal channel development and road construction on landscape patch change during 1989–2016.Spatial distribution history of three wetlands,which covered by Phragmites australis(freshwater marsh,FM),Suaeda salsa(salt marsh,SM),and mudflats(MD)were also established.Results indicated that tidal channel,number,frequency,and fractal dimension were all the maximum in 2003,and the minimum in 1998,respectively.Road length,number,and density showed increasing trend during 1989–2016.MD were the predominant landscape type,followed by FM and SM during 1989-2016.Principal component analysis implied two extracted factors,F1 and F2,which could represent 91.93% of the total variations.F1 mainly proxied tidal channel development,while F2 represented road construction.A multiple linear regression analysis showed positive effects of both F1 and F2 on FM patch numbers and negative impacts on SM patch areaes with R^2 values of 0.416 and 0.599,respectively.Tidal channels were negatively related to MD patch numbers,while roads were positively related to that.In any case,road construction showed larger impacts on landscape type shifting than that of tidal channel development in the YRD. 展开更多
关键词 TIDAL channel development road construction principal component ANALYSIS multiple linear regression ANALYSIS the YELLOW River DELTA
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