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Prevention of macrovascular complications in patients with type 2 diabetes mellitus: Review of cardiovascular safety and efficacy of newer diabetes medications 预览
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作者 Ravi Kant Kashif M Munir +1 位作者 Arshpreet Kaur Vipin Verma 《世界糖尿病杂志:英文版(电子版)》 2019年第6期324-332,共9页
Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized cont... Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician’s armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors. 展开更多
关键词 Newer antidiabetic MEDICATIONS Glucagon-like peptide-1 receptor agonist Sodium-glucose cotransporter-2 inhibitors Type 2 DIABETES MELLITUS Macrovascular complications CARDIOVASCULAR outcome trials Major CARDIOVASCULAR events HEART failure PREVENTION of HEART disease
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Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron 预览
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《世界糖尿病杂志:英文版(电子版)》 2019年第3期169-180,共12页
The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (... The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (DE) are impaired synaptic adaptation and diminished spatial learning capacity. Chronic and progressive cognitive dysfunction, perpetuated by several positive feedback mechanisms in diabetic subjects, facilitates the development of early-onset dementia and Alzheimer’s disease. Despite the numerous clinical manifestations of DE having been described in detail and their pathophysiological substrate having been elucidated in both type 1 and type 2 diabetes mellitus, an effective therapeutic approach is yet to be proposed. Therefore, the aim of this review is to summarize the growing body of evidence concerning the effect of current antidiabetic treatment options on diabetic and non-DE. 展开更多
关键词 MEMORY Spatial learning Cognitive Neural REMODELING Type 2 diabetes MELLITUS ANTIDIABETIC drugs
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黄精属植物抗糖尿病本草学、物质基础及其作用机制研究进展
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作者 陶爱恩 赵飞亚 +3 位作者 王莹 夏从龙 范敏 段宝忠 《中国实验方剂学杂志》 CAS CSCD 北大核心 2019年第15期15-24,共10页
黄精属(Polygonatum)隶属于百合科(Liliaceae),多数植物为'药食同源'类中药材,多具有养阴润燥、生津止渴等功效,民间常用于治疗'口干食少、内热消渴'等证,临床广泛用于糖尿病、高血脂及肿瘤康复。随着黄精属基础研究不... 黄精属(Polygonatum)隶属于百合科(Liliaceae),多数植物为'药食同源'类中药材,多具有养阴润燥、生津止渴等功效,民间常用于治疗'口干食少、内热消渴'等证,临床广泛用于糖尿病、高血脂及肿瘤康复。随着黄精属基础研究不断深入及产业化开发的发展,其防治糖尿病的效应成分群与作用机制不断被揭示。该文通过梳理古代本草及现代文献,对黄精属植物抗糖尿病的本草学、物质基础及其作用机制的研究进行综述,结果表明黄精属在古代本草文献和现代研究中的相关证据支持其用于糖尿病的治疗,其物质基础主要为多糖、黄酮和皂苷类成分。其中,多糖类成分是其降血糖的主要化学成分,其在抗糖尿病领域具有巨大的开发潜力。虽然目前已有学者对黄精属植物抗糖尿病药效和物质基础开展了相关研究,但缺乏系统性,且药效、作用机制、代谢途径等尚不清楚。因此,进一步加强黄精属植物相关研究,特别是从中筛选出显著的活性物质,并对其物质基础、药效学和作用机制开展研究,将对抗糖尿病药物的研发和黄精属植物的开发利用具有重要的现实意义。 展开更多
关键词 黄精属 本草学 物质基础 作用机制 抗糖尿病
Anti-inflammatory properties of antidiabetic agents 预览
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作者 Eleni Xourgia Eleni-Margarita Tzouganatou +1 位作者 Athanasia Papazafeiropoulou Andreas Melidonis 《世界荟萃分析杂志》 2019年第4期129-141,共13页
The reciprocal relationship between hyperglycemia and inflammation in the setting of diabetes mellitus has been the subject of extensive research. Insulin resistance, the hallmark of diabetic metabolic dysregulation, ... The reciprocal relationship between hyperglycemia and inflammation in the setting of diabetes mellitus has been the subject of extensive research. Insulin resistance, the hallmark of diabetic metabolic dysregulation, has been linked to the inflammatory cascade occurring mainly in adipose tissue. The main pathophysiologic processes facilitating the aforementioned interplay, is a phenotype switch of macrophages to the M1 class following gluco- and lipotoxicity and gut microbial remodeling. Given the correlation between inflammation and metabolic abnormalities, the elucidation of the exact mechanisms linking the two along with exploring the possible role of modulation of one in order to alter the other, could open up the possibility of novel therapeutic approaches for diabetes mellitus and its complications. Therefore, the aim of this review is to summarize the growing body of evidence concerning the molecular basis and results of pro-inflammatory processes in diabetic subjects along with the effect of current antidiabetic treatment options on tissue inflammation. 展开更多
关键词 INFLAMMATION ADIPOSE tissue ANTI-INFLAMMATORY Type 2 diabetes MELLITUS ANTIDIABETIC DRUGS
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Antidiabetic agents in patients with hepatic impairment 预览
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作者 Athanasia Papazafiropoulou Andreas Melidonis 《世界荟萃分析杂志》 2019年第8期380-388,共9页
Chronic liver disease (CLD) often coexists with type 2 diabetes mellitus, making diabetes management a challenge to the clinician. It is well known that liver is the major site of drug metabolism, and, therefore, its ... Chronic liver disease (CLD) often coexists with type 2 diabetes mellitus, making diabetes management a challenge to the clinician. It is well known that liver is the major site of drug metabolism, and, therefore, its impairment affects hepatic metabolism of many antidiabetic agents. Furthermore, patients with CLD have serious comorbidities such as impaired renal function, hypoalbuminemia, lactic acidosis, hypoglycemia and malnutrition, making their treatment even more difficult. On the other hand, most of the antidiabetic agents, with the exception of insulin, need dosage titration due to alterations to their pharmacokinetics in patients with CLD. For well-established antidiabetic treatments, like metformin and sulfonylureas there are studies regarding their dosage chance in these patients. However, despite the growing problem of management of diabetes in patients with CLD the existing literature data, especially on newer antidiabetic agents, are limited and, furthermore, no direct guidelines exist. Therefore, in the present review article we try to summarize the existing literature data regarding management of diabetes in patients with CLD. 展开更多
关键词 HEPATIC IMPAIRMENT Type 2 diabetes MELLITUS PHARMACOKINETICS ANTIDIABETIC DRUGS
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Salacca zalacca:A short review of the palm botany, pharmacological uses and phytochemistry
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作者 Mohammed S.M.Saleh Mohammad Jamshed Siddiqui +4 位作者 Ahmed Median Nor Hadiani Ismail Qamar Uddin Ahmed Siti Zaiton Mat So’ad Salima Saidi-Besbes 《亚太热带医药杂志:英文版》 SCIE CAS 2018年第12期645-652,共8页
Salacca zalacca(Gaertn.) Voss(family Arecaceae) is the snake fruit commonly known in Malay language as salak in Malaysia. This exotic fruit has diverse and potential pharmacological properties due to its high antioxid... Salacca zalacca(Gaertn.) Voss(family Arecaceae) is the snake fruit commonly known in Malay language as salak in Malaysia. This exotic fruit has diverse and potential pharmacological properties due to its high antioxidant content. It is often consumed due to its sweet taste. The abundant natural sugar and fibre along with minerals and vitamin makes it a nutritious fruit. Phytochemical investigation on this fruit has revealed the presence of flavonoids, phenolics, glycosides as well as some volatile and aromatic compounds, including gallic acid, quercetin, chlorogenic acid, epicatechin, proanthocyanidins, lycopene and β-carotene. Pharmacological studies on the fruit flesh and peel have shown some tremendous antioxidant, anti-inflammatory, anticancer and antidiabetic potential. This review provides the botanical information of Salacca zalacca as well as its scientific investigations involving the distinct pharmacological and phytochemical benefits. This could help in highlighting the lacking data and research gaps on this plant. 展开更多
关键词 Snake fruit Salacca zalacca ARECACEAE Antioxidant ANTIDIABETIC ANTICANCER
抗糖尿病药物基因组学的研究进展
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作者 尹影 李蕊 +4 位作者 李晓黎 吴坤荣 李玲 杨蕊 李妍 《中国医院药学杂志》 北大核心 2018年第24期2607-2611,共5页
糖尿病是当前威胁全球的重要慢性疾病之一,药物在糖尿病治疗的过程中占有重要地位。药物基因组学确定了个人遗传信息的使用,以其指导药物治疗,已成为实现“个性化医学”的重要工具之一,并且在临床个体化用药、评估药物不良反应发生风险... 糖尿病是当前威胁全球的重要慢性疾病之一,药物在糖尿病治疗的过程中占有重要地位。药物基因组学确定了个人遗传信息的使用,以其指导药物治疗,已成为实现“个性化医学”的重要工具之一,并且在临床个体化用药、评估药物不良反应发生风险和指导新药研发方面起着越来越重要的作用。本文通过文献检索,对近几年抗糖尿病药物在基因组学方面的研究进展做一综述,以期对临床个体化用药提供参考。 展开更多
关键词 2型糖尿病 抗糖尿病药物 药物基因组学 基因多态性
Effects of antidiabetic drugs on epicardial fat 预览
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作者 Eleni Xourgia Athanasia Papazafiropoulou Andreas Melidonis 《世界糖尿病杂志：英文版（电子版）》 2018年第9期141-148,共8页
Epicardial adipose tissue is defined as a deposit of adipoSubmit cytes with pathophysiological properties similar to those of visceral fat,located in the space between the myocardial muscle and the pericardial sac.Whe... Epicardial adipose tissue is defined as a deposit of adipoSubmit cytes with pathophysiological properties similar to those of visceral fat,located in the space between the myocardial muscle and the pericardial sac.When compared with subcutaneous adipose tissue,visceral adipocytes show higher metabolic activity,lipolysis rates,increased insulin resistance along with more steroid hormone receptors.The epicardial adipose tissue interacts with numerous cardiovascular pathways via vasocrine and paracrine signalling comprised of pro-and anti-inflammatory cytokines excretion.Both the physiological differences between the two tissue types,as well as the fact that fat distribution and phenotype,rather than quantity,affect cardiovascular function and metabolic processes,establish epicardial fat as a biomarker for cardiovascular and metabolic syndrome.Numerous studies have underlined an association of altered epicardial fat morphology,type 2 diabetes mellitus(T2DM)and adverse cardiovascular events.In this review,we explore the prospect of using the epicardial adipose tissue as a therapeutic target in T2DM and describe the underlying mechanisms by which the antidiabetic drugs affect the pathophysiological processes induced from adipose tissue accumulation and possibly allow for more favourable cardiovascular outcomes though epicardial fat manipulation. 展开更多
关键词 EPICARDIAL FAT ADIPOSE tissue Type 2 diabetes MELLITUS ANTIDIABETIC DRUGS
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分子对接技术筛选黑沙蒿中黄酮类化合物的PPAR-γ激动活性成分 预览 被引量：2
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作者 肖音 肖斌 +3 位作者 赵娜 张娜 武心亮 苏伊新 《中国药房》 北大核心 2018年第1期58-62,共5页
目的：从黑沙蒿所含黄酮类化合物中筛选过氧化物酶体增殖物激活受体y（PPAR-7）的激动活性成分，为发现黑沙蒿中抗糖尿病药效物质提供参考。方法：以已知PPAR-γ激动药罗格列酮为阳性对照，采用分子对接技术对黑沙蒿中已分离得到的18个... 目的：从黑沙蒿所含黄酮类化合物中筛选过氧化物酶体增殖物激活受体y（PPAR-7）的激动活性成分，为发现黑沙蒿中抗糖尿病药效物质提供参考。方法：以已知PPAR-γ激动药罗格列酮为阳性对照，采用分子对接技术对黑沙蒿中已分离得到的18个黄酮类化合物与PPAR-y靶点进行一一分子对接，并对化合物与PPAR-y靶点的对接亲和力、对接构象等进行分析比较，筛选黑沙蒿中可能的PPAR—γ激动活性成分。结果：有5个黄酮类化合物呈现了较好的对接亲和力，其中以化合物3（5，3＇，4＇-三羟基-7-甲氧基黄酮）亲和力最高（-8．3kcal／m01）；对接构象分析发现，黄酮类化合物A环与B环上的氧原子易与PPAR-γ配体结合域活性位点形成1个（Tyr327）或2个（Tyr327、Arg288）氢键结合，这对于黄酮类化合物与PPAR-γ的结合以及PPAR—γ构象的稳定起着重要作用。结论：采用分子对接技术进行的虚拟筛选结果表明，黑沙蒿中的黄酮类化合物（大多含有多个自由酚羟基）易与PPAR-γ形成较好的对接模式与较高亲和力，具有潜在抗糖尿病活性；本研究可为黑沙蒿治疗2型糖尿病的化学成分研究提供参考。 展开更多
关键词 黑沙蒿 分子对接技术 黄酮类化合物 过氧化物酶体增殖物激活受体-Γ 亲和力 抗糖尿病
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α-Glucosidase inhibitors and antioxidants from root bark of Morusalba
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作者 Bing-rui Liu Tie-ning Yan +1 位作者 Jian Xiao Xiao-ling Wang 《中草药：英文版》 CAS 2018年第3期331-335,共5页
Objective： To study the chemical constituents from root bark of Morus alba and their α-glucosidase inhi-bition and DPPH radical scavenging activities.Methods： The chemical constituents were isolated and purified by... Objective： To study the chemical constituents from root bark of Morus alba and their α-glucosidase inhi-bition and DPPH radical scavenging activities.Methods： The chemical constituents were isolated and purified by repeated column chromatographies onsilica gel, Sephadex LH-20, and preparative HPLC. Their structures were elucidated by 1D and 2D NMRspectra and HR-ESI-MS.Results： Thirteen compounds 1-13 were isolated and identified. The bioactive assays revealed that com-pounds 1, 3 and 8 displayed strong α-glucosidase inhibitory activity with ICso values of （147.1±1.1）,（314.1±0.8）, and （207.6±0.1 ） μmol/L, respectively, which were stronger than the positive control of acar-bose （418.6±0.1 μmol/L）. Compounds 10 and 11 displayed potent DPPH scavenging activity with ECsovalues of （2.9±0.1） and （5.0±0.1） μmol/L [ECso of positive control Vitamin C was （54.8±0.1） μmol/L],respectively.Conclusion： To the best of our knowledge, this is the first report about the compounds 1, 3, and 8 of M.alba with α-glucosidase inhibitory effects. 展开更多
关键词 Α-GLUCOSIDASE ANTIDIABETIC ANTI-OXIDANT flavonoid MORUS ALBA L.
芙蓉菊化学成分及其生物活性研究进展
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作者 吴琦 王亚君 +2 位作者 赵琳 杨秀伟 马爱进 《药物评价研究》 CAS 2017年第12期1821-1827,共7页
芙蓉菊Crossostephium chinense为菊科蕲艾属植物,主要分布在我国东南部地区及东南亚各国。芙蓉菊叶入药有袪风湿、消肿毒的作用;根入药治疗风湿关节痛和胃脘冷痛;广东民间用其治疗糖尿病,效果良好。现代研究显示芙蓉菊中含有挥发油、... 芙蓉菊Crossostephium chinense为菊科蕲艾属植物,主要分布在我国东南部地区及东南亚各国。芙蓉菊叶入药有袪风湿、消肿毒的作用;根入药治疗风湿关节痛和胃脘冷痛;广东民间用其治疗糖尿病,效果良好。现代研究显示芙蓉菊中含有挥发油、黄酮类、倍半萜类、三萜类、香豆素类、多糖等化学成分;其提取物或单体具有抗糖尿病、抗氧化、镇痛消炎、保肝、抗增殖等生物活性,在治疗糖尿病等方面具有潜在开发前景。 展开更多
关键词 芙蓉菊 三萜 黄酮 生物活性 抗糖尿病
苦参降血糖活性部位分散片剂型研究 预览 被引量：1
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作者 刘瑞驹 袁经权 《中国医药导报》 CAS 2017年第10期17-21,共5页
目的 对具有显著降糖活性的苦参乙酸乙酯部位进行分散片处方工艺研究,为工业化生产和临床应用奠定基础。方法 以分散片硬度、崩解度为考察指标,通过正交试验确定最佳处方工艺。采用转篮法测定溶出度,并计算累积溶出度百分率。结果 最佳... 目的 对具有显著降糖活性的苦参乙酸乙酯部位进行分散片处方工艺研究,为工业化生产和临床应用奠定基础。方法 以分散片硬度、崩解度为考察指标,通过正交试验确定最佳处方工艺。采用转篮法测定溶出度,并计算累积溶出度百分率。结果 最佳处方工艺为主药量25%,1.0%阿斯巴甜作为矫味剂,1.4~1.6 m L/100 g浓度的蒸馏水作为润湿剂,0.5%硬脂酸镁作为润滑剂,2.0%PVPP作为崩解剂,MCC-预胶化淀粉（3︰1）作为填充剂。苦参分散片的累积溶出度平均值为82.65%。结论 苦参分散片处方工艺合理可行,可用于苦参分散片的制备及质量控制。 展开更多
关键词 苦参 处方工艺 抗糖尿病 分散片
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2014—2016年常熟市第二人民医院抗糖尿病药应用分析 预览
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作者 徐振亚 张桂芬 刘英 《中国医院用药评价与分析》 2017年第7期953-956,960共5页
目的：了解常熟市第二人民医院（以下简称＂该院＂）抗糖尿病药应用情况,为临床合理用药提供参考。方法：采用回顾性方法,参照世界卫生组织推荐的限定日剂量法,对2014—2016年该院抗糖尿病药的销售金额及其年增长率、构成比,用药频度（d... 目的：了解常熟市第二人民医院（以下简称＂该院＂）抗糖尿病药应用情况,为临床合理用药提供参考。方法：采用回顾性方法,参照世界卫生组织推荐的限定日剂量法,对2014—2016年该院抗糖尿病药的销售金额及其年增长率、构成比,用药频度（defined daily dose system,DDDs）和限定日费用等指标进行评价与分析。结果：2014—2016年该院抗糖尿病药销售金额分别为1 157.59、1 204.00、1 225.81万元,呈逐年增长趋势,2015年比2014年增长了4.01%、2016年比2015年增长了1.81%,其占西药总销售金额的比例变化不大。3年来,销售金额排序居第1、2位的分别为胰岛素类似物、磺酰脲类药物,DDDs排序居第1、2位的分别为双胍类药物、磺酰脲类药物;销售金额排序居前3位的药品依次为重组甘精胰岛素注射液、门冬胰岛素30注射液和阿卡波糖片,销售金额排序居前10位药品的销售金额累计占抗糖尿病药销售金额的比例〉80%;DDDs排序居前3位的药品依次为二甲双胍（缓释）片、吡格列酮片和格列齐特缓释片,DDDs排序居前10位药品的DDDs累计占抗糖尿病药DDDs的比例〉85%。结论：该院抗糖尿病药的使用基本合理,符合目前抗糖尿病药使用规律和趋势。但仍应加强对糖尿病患者的宣传教育,实施个体化给药。 展开更多
关键词 抗糖尿病药 销售金额 用药频度 构成比 用药分析
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辣木黑茶主要药效学研究 被引量：1
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作者 邵国强 蒋席高 +4 位作者 陈历清 刘迪凡 李心亮 肖梅英 翦林宏 《湖南中医杂志》 2017年第3期154-156,共3页
目的：探讨辣木黑茶的主要药效作用。方法：通过观察辣木黑茶对自由饮食小鼠体质量的影响研究其减肥的功效;通过观察辣木黑茶对小鼠脾指数和胸腺指数的影响研究其调节免疫功能的作用;通过观察辣木黑茶对糖尿病模型大鼠的影响研究其调节... 目的：探讨辣木黑茶的主要药效作用。方法：通过观察辣木黑茶对自由饮食小鼠体质量的影响研究其减肥的功效;通过观察辣木黑茶对小鼠脾指数和胸腺指数的影响研究其调节免疫功能的作用;通过观察辣木黑茶对糖尿病模型大鼠的影响研究其调节血糖的作用;通过观察辣木黑茶对高脂血症模型大鼠的影响研究其调节血脂的作用。结果：辣木黑茶能够显著降低自由饮食小鼠的体质量,且对小鼠免疫功能无影响,与空白组比较,差异有统计学意义（P〈0.01）;辣木黑茶组小鼠胸腺指数显著升高,与空白组比较,差异有统计学意义（P〈0.05）;辣木黑茶能够降低糖尿病大鼠血糖值,与模型组比较,差异有统计学意义（P〈0.05）;辣木黑茶能够显著降低高脂血症大鼠血清TC、TG、LDL水平,与模型组比较,差异有统计学意义（P〈0.01或P〈0.05）。结论：辣木黑茶具有减肥、降血脂、降血糖等功效。 展开更多
关键词 辣木黑茶 减肥 降血脂 降血糖 实验研究
基于实心核颗粒色谱技术结合HPLC法快速测定保健食品中非法添加13种降糖化学成分 被引量：5
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作者 励炯 曹青文 +3 位作者 王姣斐 扈明洁 江海 贾彦博 《中草药》 CSCD 北大核心 2017年第13期2666-2673,共8页
目的建立保健食品中非法添加13种降糖性化学成分（甲苯磺丁脲、格列本脲、格列齐特、格列吡嗪、格列喹酮、格列美脲、马来酸罗格列酮、瑞格列奈、盐酸吡格列酮、盐酸二甲双胍、盐酸苯乙双胍、盐酸丁二胍、格列波脲）的HPLC快速检测方法... 目的建立保健食品中非法添加13种降糖性化学成分（甲苯磺丁脲、格列本脲、格列齐特、格列吡嗪、格列喹酮、格列美脲、马来酸罗格列酮、瑞格列奈、盐酸吡格列酮、盐酸二甲双胍、盐酸苯乙双胍、盐酸丁二胍、格列波脲）的HPLC快速检测方法。方法以高色谱性能的实心核颗粒色谱柱CORTECS-C18（100 mm×4.6 mm,2.7μm）快速分离,二极管阵列检测器（PDA）检测,进行定性定量检测分析,样品以甲醇为溶剂超声提取,在10 min内同时检测添加在保健食品中的甲苯磺丁脲、格列本脲、格列齐特、格列吡嗪、格列喹酮、格列美脲、马来酸罗格列酮、瑞格列奈、盐酸吡格列酮、盐酸二甲双胍、盐酸苯乙双胍、盐酸丁二胍、格列波脲13种化学成分。结果 13种降糖化学成分色谱检测的分离度好,线性范围宽,相关性好,r2≥0.998 7;方法精密度以6次测定值的RSD表示,为0.6%~1.5%;方法回收率用3个质量浓度进行添加实验,回收率为95.9%~104.7%;定量限为1.1~3.3μg/m L;日间精密度的RSD为0.5%~1.6%（n=9）。86批降糖类保健食品中检出17批添加化学药,检出率为20%;样品中检出了格列本脲、盐酸苯乙双胍、马来酸罗格列酮、格列美脲、盐酸二甲双胍、盐酸吡格列酮。结论本方法通用性强,操作简单、快捷,可作为保健食品中非法添加13种降糖化学成分的有效检测方法。 展开更多
关键词 实心核颗粒 保健食品 降糖 非法添加 HPLC 甲苯磺丁脲 格列本脲 格列齐特 格列吡嗪 格列喹酮 格列美脲 马来酸罗格列酮 瑞格列奈 吡格列酮 盐酸二甲双胍 盐酸苯乙双胍 盐酸丁二胍 格列波脲
五味子抗糖尿病和抗氧化作用研究进展 预览 被引量：10
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作者 金银萍 李珊珊 +3 位作者 郑颖 郭靖 焉石 王英平 《特产研究》 2017年第1期64-68,共5页
五味子作为我国传统著名中药,已有2000多年的药用历史,其药理作用受到广泛关注。近年研究报道表明,五味子具有保肝、抑制中枢神经、抗氧化、抗肿瘤等多种药理活性,尤其在防治2型糖尿病及慢性并发症方面具有良好的应用前景。现对五味子... 五味子作为我国传统著名中药,已有2000多年的药用历史,其药理作用受到广泛关注。近年研究报道表明,五味子具有保肝、抑制中枢神经、抗氧化、抗肿瘤等多种药理活性,尤其在防治2型糖尿病及慢性并发症方面具有良好的应用前景。现对五味子抗糖尿病和抗氧化作用的相关研究进展进行综述,为五味子的深入开发利用提供参考。 展开更多
关键词 五味子 抗糖尿病 抗氧化
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Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes 预览
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作者 Olusola Olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu +2 位作者 Jean Paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo 《世界糖尿病杂志：英文版（电子版）》 2017年第7期337-345,共9页
Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adi... Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents. 展开更多
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A review on promising phytochemical, nutritional and glycemic control studies on Moringa oleifera Lam. in tropical and sub-tropical regions
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作者 Hafiz Irfan Muhammad Mohd Zaini Asmawi Nurzalina Abdul Karim Khan 《亚太热带生物医学杂志：英文版》 CAS 2016年第10期896-902,共7页
Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scie... Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scientists using the folk claim as guides to explore medicinal plants. Moringa oleifera is a famous edible plant having therapeutic and nutritive values. The present study was designed to cumulate the research data regarding to what extent, phytochemical, nutritional and glycemic control studies has been explored using its different extracts. The articles indicated that the powder, aqueous, methanol and ethanol extracts of Moringa oleifera(leaves, pods, seeds, stem and root bark) have significant therapeutic herbal potential to treat diabetes mellitus. Collectively, the mechanism behind is intestinal glucose inhibition, insulin release as well as decrease in insulin resistance probably regeneration of b-cells of pancreas, increase in glutathione and reduction in malondialdehyde. Conclusively, this article give descriptive information about antidiabetic effect, claimed marker compounds and proposed antihyperglycemic mechanism of a single plant. It can be suggested a potential herbal source to treat diabetes mellitus as being widely accepted by major population as nutrition and therapeutic agent. 展开更多
关键词 ANTIHYPERGLYCEMIC Aqueous Ethanol Moringa oleifera ANTIDIABETIC
具有降糖作用的鼠李糖乳杆菌生物学特性研究 预览 被引量：1
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作者 陈佩 党辉 +1 位作者 王伟 陈卫 《食品工业科技》 CAS CSCD 北大核心 2016年第21期162-165,171共5页
摘要：本研究旨在评价一株具有降糖作用的鼠李糖乳杆菌的生物学特性。结果表明，该菌株生长较快，2h进入生长对数期，14h后进入稳定期，最适生长pH为5—7，最适生长温度为37℃，最适接种量为1％-2％（V／V）。此外，该菌株在强酸条件下... 摘要：本研究旨在评价一株具有降糖作用的鼠李糖乳杆菌的生物学特性。结果表明，该菌株生长较快，2h进入生长对数期，14h后进入稳定期，最适生长pH为5—7，最适生长温度为37℃，最适接种量为1％-2％（V／V）。此外，该菌株在强酸条件下可以生长，对人工胃肠液都具有很好的耐受性，耐受胆盐的延迟时间为0．86h，在NaCI浓度为9％（W／V）的培养条件下仍可以存活。更为重要的是，这株菌对Caco-2细胞具有较强的粘附能力。综上所述：该鼠李糖乳杆菌菌株可作为一株具有潜在降糖作用的发酵菌株，用以开发具有降糖作用的新型发酵产品。 展开更多
关键词 降糖 鼠李糖乳杆菌 生物学特性
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Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L.leaves extract in normal and streptozotocin-induced diabetic rats 被引量：1
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作者 Leila Mousavi Rabeta Mohd Salleh +1 位作者 Vikneswaran Murugaiyah Mohd Zaini Asmawi 《亚太热带生物医学杂志：英文版》 CAS 2016年第12期1029-1036,共8页
Objective:To investigate the antidiabetic activity of Ocimum tenuiflorum L.(O.tenuiflorum) leaves used in the traditional medicine management of diabetes in Malaysia.Methods:O.tenuiflorum leaves were extracted sequent... Objective:To investigate the antidiabetic activity of Ocimum tenuiflorum L.(O.tenuiflorum) leaves used in the traditional medicine management of diabetes in Malaysia.Methods:O.tenuiflorum leaves were extracted sequentially with hexane,chloroform,ethyl acetate,methanol,and water.The extracts were evaluated in terms of antidiabetic activity by using acute,subcutaneous glucose tolerance,and sub-chronic tests in streptozotocininduced diabetic rats.The extracts were also subjected to phytochemical analyses.Results:With an acute dose(1 g/kg),the methanol extracts showed significant reduction(31%) in fasting blood glucose(FBG) of the streptozotocin-induced diabetic rats.The FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts;the decreasing rates were 20%after 2 h,21%after 3 h,and 8%after 5 and 7 h.After 7 h(31%),the effect of methanol extract on FBG was significantly lower than that of metformin.In the subcutaneous glucose tolerance test,only methanol and hexane extracts showed the similarity of metformin in diabetic rats.After 14 days,the effects of these extracts were similar to those of metformin(63.33%).The total flavonoid and phenolic contents of extracts decreased as the polarity of the extraction solvent increased.Conclusions:The results obtained provide support for a possible use of O.tenuiflorum leaves in managing hyperglycemia and preventing the complications associated with it in type 2 diabetic. 展开更多
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