期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
皱皮木瓜总酚酸分离纯化工艺及生物活性研究 预览 被引量:1
1
作者 肖敏 舒佳为 +2 位作者 覃瑞 刘虹 杨光忠 《中国现代中药》 CAS 2018年第3期316-322,共7页
目的:筛选皱皮木瓜总酚酸的大孔树脂纯化工艺,对其生物活性进行初步探索。方法:以皱皮木瓜总酚酸质量浓度为指标,考察多种型号大孔树脂纯化总酚酸的吸附及洗脱条件。通过对纯化后样品清除自由基能力评价其抗氧化活性,通过对纯化后... 目的:筛选皱皮木瓜总酚酸的大孔树脂纯化工艺,对其生物活性进行初步探索。方法:以皱皮木瓜总酚酸质量浓度为指标,考察多种型号大孔树脂纯化总酚酸的吸附及洗脱条件。通过对纯化后样品清除自由基能力评价其抗氧化活性,通过对纯化后样品抑制α-淀粉酶和α-葡萄糖苷酶的活性,评价纯化后样品的抗氧化和抗糖尿病活性。结果:D101型大孔树脂为分离纯化皱皮木瓜总酚酸的最佳树脂,最佳工艺为上样浓度1 mg·mL-1,流速2 BV·h-1,上样体积20 BV,水洗除杂用量4 BV,流速2 BV·h-1,洗脱剂60%乙醇,洗脱剂用量4 BV,洗脱流速4 BV·h-1。纯化后样品对DPPH和ABTS+的半数抑制浓度分别为(0.038±0.006)mg·mL-1、(5.428±0.163)0x0E?SymbolmA@0x0Fg·mL-1,对α-淀粉酶和α-葡萄糖苷酶的半数抑制浓度为(0.34±0.001)、(0.071±0.024)mg·mL-1。结论:在最佳工艺条件下,皱皮木瓜总酚酸含量由30.3%提高到71.1%,结果表明,皱皮木瓜总酚酸具有一定的抗氧化和抗糖尿病活性。 展开更多
关键词 皱皮木瓜 总酚酸 纯化工艺 抗氧化活性 抗糖尿病活性
在线阅读 下载PDF
Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats
2
作者 Rooh Ullah Shafiq Ahmed Tariq +3 位作者 Naeem Khan Nawaz Sharif Zia Ud Din Khalid Mansoor 《亚太热带生物医学杂志:英文版》 CAS 2017年第7期619-623,共5页
Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla... Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin.Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract.Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature. 展开更多
Antidiabetic activity of methanolic bark extract of Alhizia odoratissima Benth.in alloxan induced diabetic albino mice 被引量:5
3
作者 Dinesh Kumar Sunil Kumar +2 位作者 Sonia Kohli Renu Arya Jyoti Gupta 《亚太热带医药杂志:英文版》 SCIE 2011年第11期900-903,共4页
【正】Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without ... 【正】Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P【0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals. 展开更多
关键词 Albizia odoratissima ANTIDIABETIC potential Methanolic EXTRACT ALLOXAN MICE
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈