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Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia 预览
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作者 Ning-Wei Zhu Xiao-Lan Yin +4 位作者 Ren Lin Xiao-Lan Fan Shi-Jie Chen Yuan-Ming Zhu Xiao-Zhen Zhao 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期332-341,共10页
Oxidative stress is involved in the pathogenesis of vascular dementia. Studies have shown that lycopene can significantly inhibit oxidative stress;therefore, we hypothesized that lycopene can reduce the level of oxida... Oxidative stress is involved in the pathogenesis of vascular dementia. Studies have shown that lycopene can significantly inhibit oxidative stress;therefore, we hypothesized that lycopene can reduce the level of oxidative stress in vascular dementia. A vascular dementia model was established by permanent bilateral ligation of common carotid arteries. The dosage groups were treated with lycopene(50, 100 and 200 mg/kg) every other day for 2 months. Rats without bilateral carotid artery ligation were prepared as a sham group. To test the ability of learning and memory, the Morris water maze was used to detect the average escape latency and the change of search strategy. Hematoxylin-eosin staining was used to observe changes of hippocampal neurons. The levels of oxidative stress factors, superoxide dismutase and malondialdehyde, were measured in the hippocampus by biochemical detection. The levels of reactive oxygen species in the hippocampus were observed by dihydroethidium staining. The distribution and expression of oxidative stress related protein, neuron-restrictive silencer factor, in hippocampal neurons were detected by immunofluorescence histochemistry and western blot assays. After 2 months of drug administration,(1) in the model group, the average escape latency was longer than that of the sham group, and the proportion of straight and tend tactics was lower than that of the sham group, and the hippocampal neurons were irregularly arranged and the cytoplasm was hyperchromatic.(2) The levels of reactive oxygen species and malondialdehyde in the hippocampus of the model group rats were increased, and the activity of superoxide dismutase was decreased.(3) Lycopene(50, 100 and 200 mg/kg) intervention improved the above changes, and the lycopene 100 mg/kg group showed the most significant improvement effect.(4) Neuron-restrictive silencer factor expression in the hippocampus was lower in the sham group and the lycopene 100 mg/kg group than in the model group.(5) The above data indicate that lycopene 100 mg/kg co 展开更多
关键词 bilateral carotid artery ligation LYCOPENE hippocampus learning and memory MALONDIALDEHYDE neuron neuron-restrictive SILENCER factor reactive oxygen species superoxide DISMUTASE
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Characterization of astrocytes and microglial cells in the hippocampal CA1 region after transient focal cerebral ischemia in rats treated with Ilexonin A 预览
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作者 Ai-Ling Xu Guan-Yi Zheng +2 位作者 Hui-Ying Ye Xiao-Dong Chen Qiong Jiang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期78-85,共8页
Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese medicine.Ilexonin A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the... Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese medicine.Ilexonin A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ischemia.However,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain unclear.Focal cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in rats.Ilexonin A(20,40 or 80 mg/kg)was administered immediately after ischemia/reperfusion.The astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot assay.Expression levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 tissue.Astrocytes were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/reperfusion.The number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin A.Microglial cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin A.Ilexonin A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/reperfusion.The results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory factors.This study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China. 展开更多
关键词 ASTROCYTES HIPPOCAMPAL CA1 REGION ilexonin A MICROGLIA middle CEREBRAL artery OCCLUSION neural stem cell neuroprotection transient focal CEREBRAL ischemia
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Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion 预览
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作者 Bei-Yao Gao Dong-Sheng Xu +6 位作者 Pei-Le Liu Ce Li Liang Du Yan Hua Jian Hu Jia-Yun Hou Yu-Long Bai 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1045-1057,共13页
Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.Ho... Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydrox 展开更多
关键词 brain-derived neurotrophic factor glutamate HIPPOCAMPUS m CIMT middle cerebral artery occlusion modified constraint-induced movement therapy α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor
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Stroke gets in your eyes:stroke-induced retinal ischemia and the potential of stem cell therapy 预览
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作者 Chase Kingsbury Matt Heyck +2 位作者 Brooke Bonsack Jea-Young Lee Cesar V.Borlongan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1014-1018,共5页
Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from ret... Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from retinal ischemia,which can inhibit their ability to make a functional recovery and may diminish their overall quality of life.Despite this,no treatments for retinal ischemia have been developed.In both cases,ischemia-induced mitochondrial dysfunction initiates a cell loss cascade and inhibits endogenous brain repair.Stem cells have the ability to transfer healthy and functional mitochondria not only ischemic neurons,but also to similarly endangered retinal cells,replacing their defective mitochondria and thereby reducing cell death.In this review,we encapsulate and assess the relationship between cerebral and retinal ischemia,recent preclinical advancements made using in vitro and in vivo retinal ischemia models,the role of mitochondrial dysfunction in retinal ischemia pathology,and the therapeutic potential of stem cell-mediated mitochondrial transfer.Furthermore,we discuss the pitfalls in classic rodent functional assessments and the potential advantages of laser Doppler as a metric of stroke progression.The studies evaluated in this review highlight stem cell-derived mitochondrial transfer as a novel therapeutic approach to both retinal ischemia and stroke.Furthermore,we posit the immense correlation between cerebral and retinal ischemia as an underserved area of study,warranting exploration with the aim of these treating injuries together. 展开更多
关键词 laser Doppler MCAO mesenchymal stem cells mitochondrial network mitochondrial transfer ophthalmic artery optic nerve oxygen-glucose deprivation regenerative medicine retinal ganglion cells visual impairment
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颈部动脉迂曲与脑动脉狭窄及脑缺血事件的相关性分析 预览
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作者 金戈 展群岭 +5 位作者 陈亮 李鑫 杨涌涛 刘丽 刘冰 张余 《局解手术学杂志》 2019年第2期125-128,共4页
目的探讨颈部动脉迂曲与脑动脉狭窄及脑缺血事件的相关性。方法回顾性分析2018年1~6月在我科完成全脑血管造影(DSA)检查的177例住院患者临床资料。根据缺血事件性质分为急性缺血性卒中组(AIS组,n=73)、短暂性脑缺血发作组(TIA组,n=62)... 目的探讨颈部动脉迂曲与脑动脉狭窄及脑缺血事件的相关性。方法回顾性分析2018年1~6月在我科完成全脑血管造影(DSA)检查的177例住院患者临床资料。根据缺血事件性质分为急性缺血性卒中组(AIS组,n=73)、短暂性脑缺血发作组(TIA组,n=62)和对照组(n=42);根据脑动脉狭窄程度分为重度狭窄组(n=42)、轻中度狭窄组(n=64)和无狭窄组(n=71)。分别测量颈内动脉(ICA)C1段和椎动脉(VA)V1段的迂曲指数(TI)。分别将每例患者双侧ICAC1段和VAV1段的TI最大值分别指定为ICA-TI和VA-TI,MAX-TI指定为ICA-TI和VA-TI的最大值。使用单因素和多因素分析探讨血管迂曲与脑动脉狭窄和脑缺血事件的相关性。结果单因素分析显示高血压的差异具有统计学意义,而ICA-TI、VA-TI和MAX-TI的差异均无统计学意义,有序多分类Logistic回归多因素分析显示ICA-TI[OR=1.044,95%CI(0.919~1.186),P=0.504]、VA-TI[OR=1.008,95%CI(0.959~1.059),P=0.767]和MAX-TI[OR=0.969,95%CI(0.844~1.114),P=0.662]均不是脑缺血事件的独立危险因素。单因素分析显示年龄、高血压病、高脂血症和糖尿病的差异具有统计学意义,而ICA-TI、VA-TI和MAX-TI的差异均无统计学意义。多因素分析显示ICA-TI[OR=1.023,95%CI(0.893~1.172),P=0.744]、VA-TI[OR=1.006,95%CI(0.953~1.06),P=0.84]和MAX-TI[OR=0.972,95%CI(0.838~1.128),P=0.712]均不是脑动脉狭窄的独立危险因素。结论颈部动脉迂曲与脑动脉狭窄及脑缺血事件无明显相关性,但迂曲是否通过其他途径影响或干预动脉粥样硬化和缺血梗死的进程还需深入研究。 展开更多
关键词 动脉 椎动脉 迂曲 脑动脉狭窄 脑缺血 动脉粥样硬化 颈内动脉 卒中
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What can we learn from cases of internal mammary artery damage in coronary artery bypass graft?
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作者 Mi Chen Fang-Jiong Huang +7 位作者 Qiang Wu Yi-Xi Zou En-Jun Zhu Jin-Wei Zhang Yuan Zhou Jian-Bo Yu Ke-Qiang Cai Bo Han 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第3期377-378,共2页
From July 1997 to April 2017, 286 cases of internal mammary artery (IMA) damage were recorded out of the 10,360 coronary artery bypass graft (CABG) operations with IMA harvest, with an incidence up to 2.7%, which is r... From July 1997 to April 2017, 286 cases of internal mammary artery (IMA) damage were recorded out of the 10,360 coronary artery bypass graft (CABG) operations with IMA harvest, with an incidence up to 2.7%, which is relatively high. The main reason for such high incidence might be the surgeons’ experience and the learning curve. Although one surgeon (Huang FJ) performed all these operations, the cases were operated in many different hospitals, and more than 200 surgical assistants who were young and inexperienced harvested the IMA. 展开更多
关键词 INTERNAL MAMMARY ARTERY (IMA) coronary ARTERY BYPASS graft (CABG) INTERNAL MAMMARY ARTERY DAMAGE
Relationship of visual impairment and peripheral artery disease with the occurrence of diabetic foot ulcers in Dr. Moewardi Hospital 预览
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作者 Okti Sri Purwanti Krisna Yetti Tuti Herawati 《护理前沿(英文)》 CAS 2019年第2期157-160,共4页
Objective: One of the diabetes mellitus (DM) complications is foot ulcers. Foot ulcers are influenced by many factors. DM puts patients at risk of injury because of visual impairment. Hyperglycemia can damage blood ve... Objective: One of the diabetes mellitus (DM) complications is foot ulcers. Foot ulcers are influenced by many factors. DM puts patients at risk of injury because of visual impairment. Hyperglycemia can damage blood vessels, which results in peripheral artery disease (PAD). The purpose of this study was to find the relationship of visual impairment and PAD with diabetic foot ulcers. Methods: This research used observational analytic study with case–control methods. It used purposive sampling in 34 DM patients with foot ulcers and 34 DM patients without foot ulcers. The research instruments were an interview guide to assess visual impairment, physical examination to assess PAD, and documentation study, which was used to know the incidence of diabetic ulcers. Results: The results showed that the respondents who experienced ulcers with visual impairment were 44.1% and the respondents who had foot ulcers with PAD were 73.5%. The results of statistical tests showed that there was no relationship between visual impairment and the incidence of ulcers (P = 0.166). The respondents with PAD will have a chance to suffer from foot ulcers 5.808 times higher than those who do not have PAD. Conclusions: There is no relationship between visual impairment and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital, but there is relationship between PAD and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital. Suggestions of this study are to do foot screening and educate about the importance of foot care to prevent the occurrence of diabetic ulcers. 展开更多
关键词 visual IMPAIRMENT peripheral ARTERY DISEASE foot ULCERS diabetes MELLITUS ARTERY DISEASE RETINOPATHY
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Internal mammary artery harvesting with its distal end occluded
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作者 Yoandy Lopez-de la Cruz Yolepsis Quintero-Fleites 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第11期1385-1386,共2页
To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose ... To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose in relation to the internal mammary artery (IMA) harvesting is very useful because they are based on a 20-year experience in more than 10,000 patients. 展开更多
关键词 CORONARY ARTERY MAMMARY LESION of internal MAMMARY ARTERY
Trans-brachial artery access for coronary artery procedures is feasible and safe: data from a single-center in Macau
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作者 U Po Lam Edmundo Patricio Lopes Lao +2 位作者 Kan Chit Lam Mario Evora Na-Qiong Wu 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第12期1478-1481,共4页
Compared with trans-femoral artery access (TFA), trans-radial artery access (TRA) for percutaneous coronary interventions (PCI) has been shown to significantly reduce 30-day mortality, in-hospital major adverse cardia... Compared with trans-femoral artery access (TFA), trans-radial artery access (TRA) for percutaneous coronary interventions (PCI) has been shown to significantly reduce 30-day mortality, in-hospital major adverse cardiac and cardiovascular events (a composite of 30-day mortality and in-hospital myocardial re-infarction, target vessel revascularization, and cerebrovascular events), major bleeding, and access site complications.[1] TRA is more easily compressible, minimizing hematoma risk, and lower crossover rates to another access. Patients may ambulate immediately after procedure, that hospitalization can be shortened significantly. In some centers, patient with TRA can be discharged on the same day of procedure. It is also superior to TFA with closure devices, and becomes the preferred access site for recent PCI.[2] 展开更多
关键词 Trans-brachial ARTERY ACCESS coronary ARTERY PROCEDURES
Percutaneous coronary intervention for ostial lesions of the left main stem in a patient with congenital single left coronary artery:A case report 预览
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作者 Qiang Wu Zong-Zhuang Li +2 位作者 Feng Yue Fang Wei Chen-Yun Zhang 《世界临床病例杂志》 2019年第15期2128-2133,共6页
BACKGROUND Single coronary artery(SCA)originating from a solitary ostium in the aorta and perfusing the entire myocardium is a very rare congenital anomaly of the coronary artery.Furthermore,a right coronary artery(RC... BACKGROUND Single coronary artery(SCA)originating from a solitary ostium in the aorta and perfusing the entire myocardium is a very rare congenital anomaly of the coronary artery.Furthermore,a right coronary artery(RCA)arising from the mid segment of the left anterior descending artery(LAD)is an extremely uncommon variation of SCA.CASE SUMMARY A 76-year-old woman presented a 5-mo history of exertional angina.Selective coronary angiography revealed an SCA,with severe ostial stenosis that originated from the left sinus of Valsalva and bifurcated normally into the LAD and circumflex coronary artery.In addition,an anomalous RCA originated from the mid segment of the LAD as a separate branch.Successful balloon angioplasty and stenting for the SCA ostial stenosis were performed on the patient.CONCLUSION Percutaneous coronary intervention(PCI)of the main trunk for SCA is very similar to PCI of an unprotected left main coronary artery.Although technical difficulties and risks do exist,PCI for severe ostial stenosis of the main trunk is safe and efficacious in selected SCA patients. 展开更多
关键词 CORONARY anomaly SINGLE CORONARY ARTERY LEFT main CORONARY ARTERY Percutaneous CORONARY intervention Case report
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Progression of carotid artery disease could stratify a risk of coronary artery disease patients with type 2 diabetes
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作者 Marijan Bosevski Pece Nikolovski +1 位作者 Lily Stojanovska Vasso Apostolopoulos 《生物化学与生物物理学报:英文版》 SCIE CAS CSCD 2019年第1期120-122,共3页
Diabetes is a common risk factor associated with coronary artery disease (CAD).Importantly,hereditary CAD cannot be discounted which accounts for about one quater of the cases [1].Carotid artery disease (CARD) shares ... Diabetes is a common risk factor associated with coronary artery disease (CAD).Importantly,hereditary CAD cannot be discounted which accounts for about one quater of the cases [1].Carotid artery disease (CARD) shares the same risk factors as CAD [2]. 展开更多
关键词 DISEASE CAROTID ARTERY DISEASE coronary ARTERY DISEASE patients with type 2 diabetes
Central retinal artery occlusion after endovascular coil embolization for internal carotid artery aneurysm
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作者 Ying-Li Wang Yan-Nian Hui +3 位作者 Ran Chen Yang-Yang Jin Jun Tao Yu-Mei Zhou 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期520-522,共3页
Dear Editor,We are writing this letter to report an unexpected rare caseofcentralretinalarteryocclusion(CRAO)happened after stent-assisted coiling for internal carotid artery(ICA)aneurysm in a female patient.CRAO is a... Dear Editor,We are writing this letter to report an unexpected rare caseofcentralretinalarteryocclusion(CRAO)happened after stent-assisted coiling for internal carotid artery(ICA)aneurysm in a female patient.CRAO is a devastating ocular emergency with poor visual prognosis and no universal acceptedtreatmentatpresent.CRAOisusuallyassociated witharterialhypertension,diabetesmellitus,renaldisease. 展开更多
关键词 Figure Central retinal ARTERY occlusion AFTER ENDOVASCULAR coil EMBOLIZATION for internal CAROTID ARTERY ANEURYSM ICA FFA
回旋支起源异常伴急性闭塞1例 预览
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作者 刘朋云 王龙 +1 位作者 白纯福 王福荣 《包头医学院学报》 CAS 2019年第7期124-124,126共2页
正常冠状动脉起源于左右冠状动脉窦,发出LAC(Left Coronary Artery)及RCA(Right Coronary Artery)两支,LAC从左冠状窦发出,RCA从右冠状窦发出。其中LAC又分出LAD(left anterior descending)及LCX(left circumflex branch)两支。冠状动... 正常冠状动脉起源于左右冠状动脉窦,发出LAC(Left Coronary Artery)及RCA(Right Coronary Artery)两支,LAC从左冠状窦发出,RCA从右冠状窦发出。其中LAC又分出LAD(left anterior descending)及LCX(left circumflex branch)两支。冠状动脉起源异常(anomalous origin of coronary artery,AOCA)是一类先天性冠状动脉(冠脉)畸形,通常是指左、右冠脉未能正常地从相对应的主动脉窦起源,而是异常开口于对侧主动脉窦或无冠窦、升主动脉甚至是肺动脉,并伴有冠脉走行的异常[1]。 展开更多
关键词 冠状动脉起源异常 急性闭塞 回旋支 ARTERY 右冠状动脉 ARTERY 左冠状窦 主动脉窦
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Celiomesenteric trunk:New classification based on multidetector computed tomography angiographic findings and probable embryological mechanisms 预览
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作者 Wei Tang Jing Shi +2 位作者 Lian-Qin Kuang Shuang-Yue Tang Yi Wang 《世界临床病例杂志》 2019年第23期3980-3989,共10页
BACKGROUND In previous studies,celiomesenteric trunk(CMT)was narrowly defined as a hepato-gastro-spleno-mesenteric(HGSM)trunk,but other possible types were ignored.With the widespread use of multidetector computed tom... BACKGROUND In previous studies,celiomesenteric trunk(CMT)was narrowly defined as a hepato-gastro-spleno-mesenteric(HGSM)trunk,but other possible types were ignored.With the widespread use of multidetector computed tomography(MDCT)angiography,it is easy to collect a large sampling of data on arterial anatomy of the abdomen in daily radiological practice.A new classification system for CMT may be created based on its MDCT angiographic findings and variation patterns.AIM To identify the spectrum and prevalence of CMT according to a new classification based on MDCT angiographic findings,and discuss the probable embryological mechanisms to explain the CMT variants.METHODS A retrospective study was carried out on 5580 abdominal MDCT angiography images.CMT was defined as a single common trunk arising from the aorta and its branches including the superior mesenteric artery and at least two major branches of the celiac trunk.Various types of CMT were investigated.RESULTS Of the 5580 patients,171(3.06%)were identified as having CMT.According to the new definitions and classification,the CMT variants included five types:Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ,which were found in 96(56.14%),57(33.33%),4(2.34%),3(1.75%)and 8(4.68%)patients,respectively.The CMT variants also were classified as long type(106 patients,61.99%)and short type(65 patients,38.01%)based on the length of single common trunk.Further CMT classification was based on the origin of the left gastric artery:Type a(92 patients,53.80%),type b(57 patients,33.33%),type c(11 patients,6.43%)and type d(8 patients,4.68%).CONCLUSION We systematically classified CMT variants according to our new classification system based on MDCT angiographic findings.Dislocation interruption,incomplete interruption and persistence of the longitudinal anastomosis could all be embryological mechanisms of various types of CMT variants. 展开更多
关键词 Celiac artery Mesenteric artery SUPERIOR Anatomic variation CLASSIFICATION Computed tomography angiography
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Clinical efficacy of different treatments and their impacts on the quality of life of octogenarians with coronary artery disease
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作者 Xiang-Yu Wu Tao Ying +5 位作者 Cheng-Qian Yin Su Wang Yu-Long Gao Yu-Tong Cheng Zhao Li Zhi-Zhong Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第22期2657-2663,共7页
Background:Coronary artery disease(CAD)in octogenarians(age of>80 years)has a high risk of mortality and high expenses.Research shows that the prevalence of CAD is higher among octogenarians than that among younger... Background:Coronary artery disease(CAD)in octogenarians(age of>80 years)has a high risk of mortality and high expenses.Research shows that the prevalence of CAD is higher among octogenarians than that among younger people,but few such patients undergo percutaneous coronary intervention(PCI)or coronary artery bypass grafting(CABG).This study aimed to evaluate different treatments w让h respect to their clinical effects and impacts on quality of life of octogenarians with CAD.Methods:Data of 519 octogenarians with CAD consecutively treated at Beijing Anzhen Hospital,Capital Medical University(Beijing,China)from January 2010 to January 2016 were collected in this study.The patients were categorized into three groups based on the treatments they received:the PCI group(n=292),CABG group(n=110),and medical treatment group(n=117).The followings were recorded during follow-up:clinical data,death(all-cause and cardiovascular-related),re-hospitalization time,Seattle Angina Questionnaire(SAQ)score,and occurrence of hemorrhagic events(cerebral bleeding,gastrointestinal bleeding,and dermal ecchymosis).Results:The median follow-up duration was 25.0(25th,75th percentile:17.0,55.5)months among 417 patients.The all-cause death rates(28.2%vs.12.0%and 14.6%,respectively)and cardiovascular-related death rates(15.4%us.3.8%and 6.4%,respectively)were significantly higher in the medical treatment group than those in the PCI group and CABG group(all P<0.05).The re-hospitalization rate for cardiovascular events was significantly lower in the CABG group than those in the PCI group and medical treatment group(3.8%vs.12.8%and 14.9%,respectively)(x^2=8.23&P=0.018).The SAQ scores of physical limitation,angina frequency,treatment satisfaction,and disease perception were significantly higher in the PCI group and CABG group than those in the medical treatment group(all P<0.05).No significant difference in the angina stability score was observed among the three groups(F=3.179,P=0.204).Conclusion:PCI and CABG result in reduced mortality and better 展开更多
关键词 Coronary artery disease OCTOGENARIAN Percutaneous coronary intervention Coronary artery bypass graft DEATH Life quality
Dissection of the Common Femoral Artery at the Bamako Anatomy Laboratory 预览
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作者 Babou Ba Abdoulaye Kanté +10 位作者 Tata Touré Moumouna Koné Ousmane Ibrahim Touré Cheikh Tidiane Diallo Komlavi David Kouamenou Abdel-Latif Issa-Touré Gaoussou Simpara Aboubacar Sidiki Fofana Mahamadou Daou Nouhoun Ongo?ba Abdel Karim Koumare 《法医学与解剖学研究(英文)》 2019年第4期68-75,共8页
Objectives: The purpose of this work was to determine the dimensions of CFA before the birth of the deep thigh artery, describe the mode of termination of the CFA, search for CFA collaterals, and describe the anatomic... Objectives: The purpose of this work was to determine the dimensions of CFA before the birth of the deep thigh artery, describe the mode of termination of the CFA, search for CFA collaterals, and describe the anatomical variations of the CFA. Methodology: This was a prospective study conducted at the Anatomy Laboratory of the Faculty of Medicine and Odonto-Stomatology of Bamako. CFA arteries of 12 fresh corpses of adults include 9 men and 3 women. A total of 24 CFA arteries were dissected and photographed. Results: The mean length of CFA was 50.9 ± 12.55 mm (range: 31 and 93 mm). Its average diameter was 9.12 ± 1.17 mm (range: 7 and 12 mm). In 70.83%, the CFA artery ended without any particularity. There was 29.17% anatomic variation in the CFA termination mode. The CFA divided into 3 branches (trifurcation) in 25%. The 3 branches were in 20.83%, the FS and a common core to LFCA and AQ;in 4.17%, they were the SFA, the DFA and the MFCA. In 4.17%, it divided into 4 branches which are: the SFA, the DFA, the MFCA and a common core to QA and LFCA. The CFA gave as collateral: circumflex superficial iliac artery in 22 cases (91.67%), superficial epigastric artery in 19 cases (79.17%), upper external pudendal artery in 20 cases (83.33%), and lower external pudendal artery in 14 cases (58.33%). We noted in our series 9 anatomical variations at the collateral level of the CFA or 37.5%. The CFA gave birth to the following branches: the MFCA in 4 cases or 16.67%, the LFCA in 1 case or 4.17%, the QA in 1 case or 4.17%, and a common core to the QA and LFCA in 3 cases or 12.5%. Conclusion: The length of CFA is important. The variations of CFA are frequent and important to know in clinical and surgical practice. 展开更多
关键词 ARTERY FEMORAL ANATOMY VARIATIONS
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桡动脉侧支穿支皮瓣在肘后皮肤严重缺损中的应用 预览
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作者 徐卿芯 崔光怀 +2 位作者 万蓁蓁 刘玉树 刘文明 《中国整形与重建外科(英文)》 2019年第1期14-17,共4页
exposed wound of deep tissue behind elbow. Methods From April 2016 to December 2018, 28 patients with posterior elbow skin and soft tissue defect with exposed bone and tendon were treated in our hospital. the radial c... exposed wound of deep tissue behind elbow. Methods From April 2016 to December 2018, 28 patients with posterior elbow skin and soft tissue defect with exposed bone and tendon were treated in our hospital. the radial collateral artery perforator flap was used to repair the wound. There were 19 cases of skin defect with ulna exposure after electric shock injury, 5 cases of hot compression injury and 4 cases of bone exposure caused by skin contusion after traffic accident. Results There is no complication after the operation, all the flaps were survived. The flaps had good quality and satisfactory recovery of appearance and function. Conclusion The lateral upper arm flap designed by perforating branch of radial collateral artery is an effective method for posterior elbow skin and soft tissue defect because of its constant anatomic position and long vascular pedicle. 展开更多
关键词 RADIAL COLLATERAL artery Soft tissue defects PERFORATOR FLAP T ransplantation
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Minor ST-segment deviations followed by tall T waves in precordial leads caused by acute left main coronary artery occlusion:A case report
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作者 詹中群 吴立昊 +3 位作者 韩利红 李静 蔡婕 栗洋 《岭南心血管病杂志:英文版》 CAS 2019年第3期197-200,共4页
A 53-year-old male with chest pain complicated with cardiogenic shock was presented to the emergency department. The electrocardiogram showed features of acute myocardial infarction due to left main coronary artery oc... A 53-year-old male with chest pain complicated with cardiogenic shock was presented to the emergency department. The electrocardiogram showed features of acute myocardial infarction due to left main coronary artery occlusion,and minor ST-segment deviations followed by tall T waves in precordial leads with concomitant left anterior fascicular block. Emergency coronary angiogram revealed left main coronary artery complete occlusion without collateral circulation. Percutaneous intervention of the left main coronary artery was then carried out. The ECG features of a left main occlusion were discussed with this case report. 展开更多
关键词 ACUTE myocardial INFARCTION CARDIOGENIC shock left main coronary artery OCCLUSION ECG
小切口与胸骨正中切口非体外循冠状动脉搭桥术的疗效分析 预览
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作者 申宇 《中国药物与临床》 CAS 2019年第1期45-47,共3页
近年来,我国人口老龄化发展速度加快,冠心病的发病率和死亡率也逐年升高,其对人类健康的危害已经远远超过肿瘤,已成为威胁人类健康的第一杀手[1].目前,冠状动脉搭桥手术(coronary artery bypass grafting,CABG)仍然是治疗冠心病最有效... 近年来,我国人口老龄化发展速度加快,冠心病的发病率和死亡率也逐年升高,其对人类健康的危害已经远远超过肿瘤,已成为威胁人类健康的第一杀手[1].目前,冠状动脉搭桥手术(coronary artery bypass grafting,CABG)仍然是治疗冠心病最有效的方法之一,尤其对于病情重、合并症多的患者.早期采用的体外循环下冠状动脉搭桥术极易引起患者全身炎症反应,死亡率比较高.随着技术水平的提高,胸外小切口冠状动脉搭桥逐渐在临床应用.笔者选取我院2017年1月至12月间行冠状动脉搭桥手术患者为研究对象78例,对比研究小切口冠脉搭桥与正中切口不停跳冠状动脉搭桥术的临床效果,现报道如下. 展开更多
关键词 不停跳冠状动脉搭桥术 胸骨正中切口 小切口 疗效分析 冠状动脉搭桥手术 非体外 artery 全身炎症反应
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一种连续动脉血糖监测设备的创新思路及设计方案
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作者 余洁 丁亚萍 +5 位作者 许勤 赵青 王蓉 曾庆化 戴琪 刘彦麟 《中华危重病急救医学》 CAS CSCD 北大核心 2019年第7期906-909,共4页
高血糖症是危重患者的常见并发症,目前临床主要以间断监测某一个时间点的末梢血糖来评估危重患者的血糖变化,这种测量方法无法体现真实的血糖波动及控制水平,更难以发现无症状的高血糖和低血糖,因此对血糖控制的指导价值有限.由于动脉... 高血糖症是危重患者的常见并发症,目前临床主要以间断监测某一个时间点的末梢血糖来评估危重患者的血糖变化,这种测量方法无法体现真实的血糖波动及控制水平,更难以发现无症状的高血糖和低血糖,因此对血糖控制的指导价值有限.由于动脉血是血糖监测采样最精确的样本,保证动脉血标本采样的准确性就成为当务之急.南京医科大学第一附属医院普外科重症加强治疗病房(ICU)自主研发了一种连续动脉血糖监测设备,并获得国家实用新型专利,这种设备能够极大提高医护工作人员的工作效率,并提供精确动态的统计数据,为医生的临床决策提供重要依据.该设备主要由动脉压力测量监护仪、程控动态血糖仪、导线、电动开关、一体化采集注射器、电动夹子、旋转电动支架、血糖试纸等部分组成,能够连续周期性地动态监测患者动脉血糖值,并进行自动记录、报警等各种附加增值功能. 展开更多
关键词 血糖监测 动脉 自动化 程控血糖仪 一体化采集器
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