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Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210 预览
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作者 Xuelian Chen Lanying Ma +7 位作者 Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期173-180,共8页
Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangio... Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces;84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. 展开更多
关键词 REACTIVE capillary HEMANGIOMAS SHR-1210 skin TOXICITY ANTI-TUMOR efficacy
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棉花膜下“一管四行”滴灌工程设计探讨 预览
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作者 张晔 《水资源开发与管理》 2019年第2期16-19,共4页
本文以新疆昌吉市头屯河灌区农田项目为例,针对棉花田间灌溉区水资源利用率较低、灌水定额偏高、水资源严重浪费等问题,提出棉花膜下“一管四行”滴灌工程的管网布置方案,并详细介绍了相关参数的计算方法。该工程采用的滴灌模式为“支管... 本文以新疆昌吉市头屯河灌区农田项目为例,针对棉花田间灌溉区水资源利用率较低、灌水定额偏高、水资源严重浪费等问题,提出棉花膜下“一管四行”滴灌工程的管网布置方案,并详细介绍了相关参数的计算方法。该工程采用的滴灌模式为“支管+辅管”,大大降低了棉花田间灌溉区的灌溉用水量,将灌溉水利用率提高到了97%,缓解了区域内水资源的供需矛盾,其经验可为类似工程提供必要的技术参考。 展开更多
关键词 节水灌溉 滴灌工程 “一管四行” 毛管 设计
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Open tubular capillary electrochromatography with block co-polymer coating for separation of β-lactam antibiotics
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作者 Liping Zhao Juan Qiao +2 位作者 Hongyi Zhang Fangnan Xie Li Qi 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第2期349-352,共4页
A new open-tubular capillary electrochromatography (OT-CEC) method for analysis of β-lactam antibiotics has been developed with unique block co-polymer coating. To obtain the highly ordered block polymer chains, reve... A new open-tubular capillary electrochromatography (OT-CEC) method for analysis of β-lactam antibiotics has been developed with unique block co-polymer coating. To obtain the highly ordered block polymer chains, reversible addition fragmentation chain transfer radical polymerization method was used to synthesize poly (maleic anhydride-styrene-N-isopropylacrylamide). The prepared block copolymer coating was characterized with NMR, fourier transform infrared spectroscopy and scanning electron microscope. Several key separation factors of OT-CEC, which including polymer amount,stability of the coating, temperature, species of organic additives, buffer pH and concentration, were investigated in detail. Our results indicated that the separation efficiency was improved greatly with the coating capillary and the three test analytes could be baseline separated. Then, the separation mechanism was briefly explored. Moreover, the proposed OT-CEC method displayed promising quantitative analysis property of the three test analytes with good linearity (R2>0.99), repeatability (relative standard deviations <0.9%) and high recovery (95.4%-106.2%). Further, the assay was applied in monitoring the three test β-lactam antibiotics (cephradine, cephalexin and amoxicillin) in serum samples, providing a useful platform for construction of novel polymer coatings in OT-CEC system and for analysis of drugs in real bio-samples. 展开更多
关键词 OPEN-TUBULAR capillary ELECTROCHROMATOGRAPHY β-Lactam antibiotics BLOCK CO-POLYMER COATING Serum drugs SEPARATION
Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability
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作者 Cui-ping Fu Sheng-yu Hao +6 位作者 Xiao-bo Xu Jian Zhou Zi-long Liu Huan Lu Li-min Wang Wei-zhong Jin Shan-qun Li 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第5期630-641,共12页
The integrity of the endothelial barrier is a determinant of the prognosis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated whether and how Sirtuin 1 (SIRT1) maintained the v... The integrity of the endothelial barrier is a determinant of the prognosis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated whether and how Sirtuin 1 (SIRT1) maintained the vascular integrity during ALI. An experimental model of ALI was established in mice through intratracheal administration of LPS (10 mg/kg). LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. Intratracheal administration of the selective SIRT1 activator SRT1720 (6.25 mg/kg) significantly attenuated LPS- induced lung injury, lung hyper-permeability and increased TJs expression, whereas intratracheal administration of the selective SIRT1 inhibitor EX527 (6.25 mg/kg) aggravated LPS-induced ALI. Similar protective effects of SIRT1 on pulmonary cellular permeability were observed in primary human pulmonary microvascular endothelial cells treated with LPS (2 mg/mL) in vitro. We further demonstrated that the RhoA/ROCK signaling pathway was activated in SIRT1 regulation of tight junction permeability. The RhoA/ROCK inhibitor Y-27632 (10 μM) increased the expression of TJs and reversed LPS- or EX527-induced hyper-permeability. In conclusion, SIRT1 ameliorates LPS-induced lung injury via decreasing endothelial tight junction permeability, possibly via RhoA/ ROCK signaling pathway. This finding may contribute to the development of new therapeutic approaches for lung injury. 展开更多
关键词 lung injury LPS SIRT1 protein RhoA/ROCK capillary ENDOTHELIAL PERMEABILITY tight junction proteins SRT1720 EX527 Y-27632 human pulmonary MICROVASCULAR ENDOTHELIAL cells
人全血的毛细管显微拉曼光谱分析 预览
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作者 张铭 彭文 +4 位作者 赖珍荃 王泓鹏 袁汝俊 何强 万雄 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2019年第3期797-801,共5页
血液中含有众多生物信息,如激素、酶、抗体等丰富的蛋白质成分。通过对血液中众多生物信息进行检测鉴定可以起到对该血液种属判定、溯源的目的。因此,血液检测技术的发展在诸如刑事案件侦破、物种鉴定、疾症预防等领域具有重要意义。目... 血液中含有众多生物信息,如激素、酶、抗体等丰富的蛋白质成分。通过对血液中众多生物信息进行检测鉴定可以起到对该血液种属判定、溯源的目的。因此,血液检测技术的发展在诸如刑事案件侦破、物种鉴定、疾症预防等领域具有重要意义。目前,传统血液检测手段多为显微观测、免疫法、DNA/基因检测法等,这些技术会对血液样本造成不可逆转的破坏性,且存在分析周期长、结构装置复杂、试验价格昂贵等问题。随着激光技术的发展,拉曼光谱技术作为一种非线性散射光谱技术,在血液检测技术中得到了应用。在血液检测技术中,拉曼光谱技术通常与共聚焦显微系统结合,对涂在载玻片上或盛放在透明容器中的血液样品进行光谱信号采集。该技术具有快速、无损等优势,但复杂的光路系统及昂贵的实验装置限制了该技术的广泛推广。为提出一种装置简单、操作简便的血液拉曼检测新技术,研究采用基于毛细管的显微拉曼技术方案采集并分析人全血的拉曼信号。血液样品通过毛细管的虹吸效应取样,与载玻片的涂样方式相比毛细管的方案具有模拟人血管、维持血液活性、减小空气对实验过程中血液成分的影响、降低激光对血液样品的灼伤效果等优势。为避开可见光部分荧光较强区域的荧光干扰,研究采用360nm紫外激光器作为激发光源,防止可见荧光信号的干扰。积分时间设为800ms,有效避免因激光长时间照射对血液样品的灼伤效果,影响实验数据的稳定性与真实性,光谱平均次数为2次,避免单次测量所带来的数据的不准确性影响。光谱扫描范围为500~1800cm^-1,结果表明此范围内可较好的避开可见光部分荧光较强区域的干扰。测得的拉曼光谱信号通过滤波去噪及基线校正进行处理。首先采用5阶离散小波变换滤波,进行1层信号分解,滤除高频噪声信号,保留� 展开更多
关键词 全血 毛细管 显微 拉曼光谱
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On-line trapping/capillary hydrophilic-interaction liquid chromatography/mass spectrometry for sensitive determination of RNA modifications from human blood
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作者 Chubo Qi Hanpeng Jiang +2 位作者 Jun Xiong Bifeng Yuan Yuqi Feng 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第3期553-557,共5页
RNA modification has recently been proposed to play important roles in biological regulation.The detection and quantification of RNA modifications generally are challenging tasks since most of the modifications exist ... RNA modification has recently been proposed to play important roles in biological regulation.The detection and quantification of RNA modifications generally are challenging tasks since most of the modifications exist in low abundance in vivo.Here we developed an on-line trapping/capillary hydrophilic-interaction liquid chromatography/electrospray ionization-mass spectrometry(on-line trapping/cHILIC/MS) method for sensitive and simultaneous quantification of RNA modifications of N~6-methyladenosine(m~6A) and 5-methylcytosine(5-mC) from human blood.The hydrophilic organic-silica hybrid monolith was prepared using sol-gel combined with "thiol-ene" click reaction for the separation of nucleosides.A poly(MAA-co-EGDMA) monolithic capillary was used as the on-line trapping column.With the developed on-line trapping/cHILIC/MS analytical platform, the detection limits of m~6A and 5-mC can reach to 0.06 fmol and 0.10 fmol.We then investigated the contents of m~6A and 5-mC in human blood RNA from healthy persons at the age of 6-14 and 60-68 years.Our results showed that both m~6A and 5-mC contents were significantly decreased in elder persons, suggesting the RNA modifications of m~6A and 5-mC are correlated to aging. 展开更多
关键词 N^6-Methyladenosine 5-Methylcytosine Hydrophilic-interaction liquid chromatography CAPILLARY monolithic column Mass spectrometry
Eff ects of the Imbibition Ability of Extinguishant in Pulverized Coals 预览
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作者 Liyan Liu Haoshuang Gong +3 位作者 Xin Shi Dong Lv Wei Tan Guorui Zhu 《天津大学学报:英文版》 EI CAS 2019年第1期45-51,共7页
The imbibition ability of extinguishant is an important factor influencing the extinguishing eff ect for smoldering fi re in pulverized coals. The coal particle size, bulk compactness, and aqueous solution properties ... The imbibition ability of extinguishant is an important factor influencing the extinguishing eff ect for smoldering fi re in pulverized coals. The coal particle size, bulk compactness, and aqueous solution properties signifi cantly aff ect the imbibition ability of extinguishment. This work aims to reveal the influence of the properties of pulverized coals and aqueous solution on the imbibition ability of extinguishant for smoldering fi re through experiments and capillary theories. The imbibition height and rate were adopted to evaluate the imbibition ability of extinguishment. The results showed that a relatively small bulk compactness and a fi ne coal particle size negatively influenced the extinguishing process dominantly because of its high surface energy and low wettability. An additive was used to adjust the properties of aqueous solution. The liquid with a larger surface tension, a smaller contact angle, and a lower viscosity induced a better imbibition ability of extinguishment. 展开更多
关键词 Pulverized COAL SMOLDERING fire IMBIBITION ABILITY CAPILLARY theories
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相对渗透率与含水饱和度关系微观机理 预览
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作者 赖令彬 潘婷婷 +3 位作者 张虎俊 邹存友 石建姿 韩洁 《科学技术与工程》 北大核心 2019年第12期115-122,共8页
经验表明大多数岩石的相对渗透率随饱和度变化曲线具有中间段为直线但两端弯曲的特征。然而,目前对于相对渗透率比值变化规律的微观机理及原因不清楚。岩石多孔介质可以认为由一束束弯曲毛细管束组成,因此岩石多孔介质渗流规律是毛细管... 经验表明大多数岩石的相对渗透率随饱和度变化曲线具有中间段为直线但两端弯曲的特征。然而,目前对于相对渗透率比值变化规律的微观机理及原因不清楚。岩石多孔介质可以认为由一束束弯曲毛细管束组成,因此岩石多孔介质渗流规律是毛细管孔隙微观渗流的宏观反映。基于毛细管孔隙的两相渗流规律,在毛细管两相流流型分析基础上,研究了毛细管不同流态的微观渗流机理,建立了相对渗透率比值和流体饱和度关系的微观机理模型,从理论上阐述了岩石相对渗透率比值随流体饱和度变化的微观机理。研究表明:相对渗透率变化的微观机理模型与多孔介质渗流的经验规律相一致;液滴流及环状流分别导致了相对渗透率曲线的上翘及下翘;弹状流流态下相对渗透率变化的微观模型与经验公式拟合曲线基本一致;弹状流是曲线出现直线规律的根本原因,也是经验公式的理论基础。 展开更多
关键词 相对渗透率 饱和度 渗流 流态 毛细管
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储气罐闷头与毛细管焊接方法研究 预览
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作者 葛宁 王晓玲 赵和明 《航天制造技术》 2019年第2期38-40,共3页
通过弯曲试验、扭转试验、拉脱试验和微观分析,对比储气罐闷头和毛细管采用激光焊和锡焊两种焊接方法的焊接质量。结果表明,激光焊和锡焊的弯曲和扭转性能相当;激光焊的拉脱性能优于锡焊;锡焊存在局部未覆盖情况,影响焊接强度,激光焊缝... 通过弯曲试验、扭转试验、拉脱试验和微观分析,对比储气罐闷头和毛细管采用激光焊和锡焊两种焊接方法的焊接质量。结果表明,激光焊和锡焊的弯曲和扭转性能相当;激光焊的拉脱性能优于锡焊;锡焊存在局部未覆盖情况,影响焊接强度,激光焊缝成型较好,未出现气孔、夹杂、裂纹等缺陷。 展开更多
关键词 闷头 毛细管 激光焊 锡焊
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Quantification of Aromatic Amino Acids in Cordyceps fungi by Micellar Electrokinetic Capillary Chromatography
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作者 WEI Xin SU Yaxia +3 位作者 HU Hankun LI Xiangtang XU Rui LIU Yiming 《武汉大学学报:自然科学英文版》 CAS CSCD 2019年第3期245-250,共6页
A facile micellar electrokinetic chromatography(MEKC) method was developed for quantification of aromatic amino acids in Cordyceps fungi. The proposed MEKC method had linear calibration curves and detection limits at ... A facile micellar electrokinetic chromatography(MEKC) method was developed for quantification of aromatic amino acids in Cordyceps fungi. The proposed MEKC method had linear calibration curves and detection limits at the μmol/L level. Contents of aromatic amino acids in Cordyceps were found in the range from 0.004 9 % to 0.028 0% for tryptophan(Trp), 0.036 6% to 0.078 1% for tyrosine(Tyr), and 0.029 1% to 0.136 2% for phenylalanine(Phe). Levels of amino acids in cultivated Cordyceps militaris were found higher than those in natural Cordyceps sinensis. Interestingly, the ratio of Tyr to its precursor, Phe, in C. sinensis(1.20 ± 0.091, n=3) was significantly higher than that in cultivated C. militaris(0.54 ± 0.170, n=3). This is likely because the enzyme-catalyzed in vivo biotransformation of Phe to Tyr is much more effective in natural C. sinensis, a biological hybrid of larva and parasitic fungus, than in cultivated C. militaris. 展开更多
关键词 aromatic amino acids MICELLAR ELECTROKINETIC capillary chromatography EDIBLE CORDYCEPS FUNGUS CULTIVATED CORDYCEPS militaris
Speciation of organomercury compounds by capillary electrophoresis with pre-column derivatization and on-line stacking
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作者 Dandan Cao Yongguang Yin Bin He 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第3期650-652,共3页
Simultaneous separation and detection of three organomercury species, namely methylmercury(MeHg),ethylmercury(EtHg), and phenylmercury(PhHg), was performed by using capillary electrophoresis(CE)with UV detection. Pre-... Simultaneous separation and detection of three organomercury species, namely methylmercury(MeHg),ethylmercury(EtHg), and phenylmercury(PhHg), was performed by using capillary electrophoresis(CE)with UV detection. Pre-column derivatization with thiosalicylic acid and on-line salt-induced stacking significantly improved the detection performance. Buffer pH, ion strength, and additive were optimized for CE separation, concentration of NaCl in sample solution and injection time were optimized for on-line stacking. The limits of detection were 76.9,83.0 and 76.4 μg/L for PhHg, EtHg and MeHg, respectively. The developed method was validated by certified reference material and liquid chromatography-atomic fluorescence spectroscopy, which suggests this method could be useful in the speciation of organomercury compounds in biological samples. 展开更多
关键词 Capillary ELECTROPHORESIS Mercury SPECIATION DERIVATIZATION ON-LINE STACKING
基于Micro-PIV的毛细管内流场的可视化研究 预览
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作者 田海栋 刘方 +1 位作者 刘江 陈强 《上海电力学院学报》 CAS 2019年第1期31-35,58共6页
采用Micro-PIV和FLUENT软件,对水包油乳液在内径为0.7mm的圆截面毛细管内的流场结构进行了实验和模拟研究,得到了毛细管内的速度矢量场分布。研究结果显示,实验结果与模拟结果较接近,毛细管内从层流到紊流的转捩发生在Re为2000左右,与... 采用Micro-PIV和FLUENT软件,对水包油乳液在内径为0.7mm的圆截面毛细管内的流场结构进行了实验和模拟研究,得到了毛细管内的速度矢量场分布。研究结果显示,实验结果与模拟结果较接近,毛细管内从层流到紊流的转捩发生在Re为2000左右,与宏观尺度管内流动的临界雷诺数接近,并未发现流动转捩提前的现象。 展开更多
关键词 MICRO-PIV 毛细管 水包油 临界雷诺数
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毛细管封口钎焊工艺研究 预览
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作者 严雅灯 《中小企业管理与科技》 2019年第9期161-162,共2页
论文介绍了一种毛细管封口钎焊工艺,该加工工艺采用电磁感应加热方式将空腔内的钎焊丝熔融成液态焊料,液态焊料冷却固化后形成充盈空腔的深堵焊栓,使钎焊丝整体速熔充盈空腔来消除微气孔,使汽车空调热力膨胀阀产品达到了消除微气孔、封... 论文介绍了一种毛细管封口钎焊工艺,该加工工艺采用电磁感应加热方式将空腔内的钎焊丝熔融成液态焊料,液态焊料冷却固化后形成充盈空腔的深堵焊栓,使钎焊丝整体速熔充盈空腔来消除微气孔,使汽车空调热力膨胀阀产品达到了消除微气孔、封口密闭、品质一致、延长使用寿命的目的. 展开更多
关键词 毛细管 封口 钎焊 工艺
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毛细管气相色谱法同时检测农产品中17种农药残留的分析 预览
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作者 杨海燕 《现代食品》 2018年第7期86-88,共3页
农业生产步伐不断加快,农药残留检测也得到了社会上的高度关注,应用毛细管气相色谱法可对大量农药残留实施同时检测。文章针对毛细管气相色谱法同时检测农产品中17种农药残留展开讨论,并提出合理化建议。
关键词 毛细管 气相色谱法 检测
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低渗透气藏启动压力梯度实验测试新方法 预览
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作者 房茂军 盛舒遥 +2 位作者 段永刚 魏明强 李昊 《重庆科技学院学报:自然科学版》 CAS 2018年第6期59-61,共3页
针对传统方法测量精度较低的不足,提出一种新的启动压力实验测量方法。基于毛细管有色液滴移动原理,进行高精度启动压力梯度测试,测试精度达到10-4~10-5mL数量级。将该方法应用于鄂尔多斯盆地临兴区块低渗气藏储层岩样启动压力梯度测试... 针对传统方法测量精度较低的不足,提出一种新的启动压力实验测量方法。基于毛细管有色液滴移动原理,进行高精度启动压力梯度测试,测试精度达到10-4~10-5mL数量级。将该方法应用于鄂尔多斯盆地临兴区块低渗气藏储层岩样启动压力梯度测试中,讨论低渗透率及含水饱和度对启动压力梯度的影响。研究结果表明,新方法测试的低渗储层启动压力梯度范围为0.69~11.06kPam,比传统方法测试的启动压力梯度值低1~2个数量级,且同一岩样的启动压力梯度随含水饱和度增加而增大。 展开更多
关键词 低渗气藏 启动压力梯度 毛细管 渗透率 含水饱和度
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毛细管口气泡的曲率半径和附加压力变化 预览
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作者 谢治辉 《大学化学》 CAS 2018年第10期110-113,共4页
通过直接绘制气泡形成过程中弯曲表面关键状态的形状示意图,得到了曲率半径随时间变化的关系曲线。利用该曲线有助于加深学生对最大泡压法测表面张力实验中曲率半径和附加压力变化的理解,同时该曲线也可用于解析一些与附加压力有关的习题。
关键词 毛细管 曲率半径 附加压力 表面张力
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IFCC参考方法在五种糖化血红蛋白检测系统评价中的应用
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作者 张天娇 蒲云罡 +7 位作者 周慧娟 马嵘 张江涛 王大光 李传保 李淼 王玉飞 张传宝 《中华检验医学杂志》 CSCD 北大核心 2018年第11期821-826,共6页
要目的以国际临床化学与检验医学联合会(IFCC)糖化血红蛋白参考方法为参比方法,对4个离子交换高效液相色谱法检测系统和1个毛细管电泳检测系统进行方法学评价研究。方法制备40个浓度水平的溶血液样本,分别用IFCC参考方法和待评价的... 要目的以国际临床化学与检验医学联合会(IFCC)糖化血红蛋白参考方法为参比方法,对4个离子交换高效液相色谱法检测系统和1个毛细管电泳检测系统进行方法学评价研究。方法制备40个浓度水平的溶血液样本,分别用IFCC参考方法和待评价的5个糖化血红蛋白检测系统进行测定,按照美国临床实验室标准化协会(CLSI)EP9-A3文件的程序进行正确度验证。使用全血样本,对5种系统的精密度、线性和分析干扰进行评价。结果IFCC参考方法测定40个溶血液样本的平均变异系数(CV)为1.4%(范围0.2%~2.5%)。经统计,5个系统测定结果未检出离群值,回归方程的斜率范围为0.990 2~1.026 7,截距范围为-0.152 6 mmol/mol ~ +0.151 2 mmol/mol,决定系数的范围为0.996 2~0.997 1,两个医学决定水平处估计值的偏倚均小于0.3%HbA1c。各系统实验室内CV均小于2%(NGSP单位)。线性评价中所有系统测定结果与理论值的百分偏差均小于5%。高浓度葡萄糖对糖化血红蛋白检测存在一定的分析干扰。结论5个糖化血红蛋白检测系统测定结果与IFCC参考方法具有较好的可比性,精密度和线性评价的结果符合相关标准的要求。 展开更多
关键词 血红蛋白A 糖基化 参考值 参考标准 色谱法 高压液相 色谱法 离子交换 电泳 毛细管 评价研究
改良毛细管免疫分型技术在冷球蛋白分型鉴定中的应用
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作者 秦绪珍 李鹏昌 +6 位作者 曹欣欣 李剑 王亚静 刘荔 刘茜 李航 苏薇 《中华检验医学杂志》 CSCD 北大核心 2018年第11期832-836,共5页
目的改良毛细管免疫分型技术用于冷球蛋白鉴定的方法建立与临床应用。方法参考文献及工作经验,建立改良毛细管免疫分型技术用于冷球蛋白鉴定。严格按照冷球蛋白采样要求,收集2016年11月至2017年7月在北京协和医院检测冷球蛋白阳性的标... 目的改良毛细管免疫分型技术用于冷球蛋白鉴定的方法建立与临床应用。方法参考文献及工作经验,建立改良毛细管免疫分型技术用于冷球蛋白鉴定。严格按照冷球蛋白采样要求,收集2016年11月至2017年7月在北京协和医院检测冷球蛋白阳性的标本78份,其中39份分别采用改良的毛细管免疫分型和免疫固定电泳方法进行分型鉴定。结果采用改良毛细管免疫分型技术,78例冷球蛋白阳性标本中鉴定出Ⅲ型冷球蛋白最多,其次是Ⅱ型、Ⅰ型,不同类型冷球蛋白血症患者临床特点与既往报道相似。在检测速度、结果判读的清晰度和准确度上,改良毛细管免疫分型技术明显优于免疫固定电泳方法,两者可报告比例为1:0.87。结论毛细管免疫分型技术是一种准确而简便易行的冷球蛋白鉴定方法,适于临床实验室使用。 展开更多
关键词 冷球蛋白类 电泳 毛细管 免疫电泳
毛细管区带电泳测定大黄提取物中有效成分的含量 预览 被引量:1
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作者 曾雪 杨元娟 +2 位作者 陈竹 刘应杰 夏培元 《重庆医学》 2018年第2期220-222,共3页
目的 采用毛细管区带电泳测定大黄提取物中大黄素、大黄酚和大黄酸的含量。方法 以熔融石英毛细管柱(67.4cm×75.0μm,有效长度51.0cm)为分离柱,60mmol/L Na2B4O7,40mmol/L Na2CO3,40mmol/Lβ-环糊精(pH 8.9)为缓冲溶液,检测波... 目的 采用毛细管区带电泳测定大黄提取物中大黄素、大黄酚和大黄酸的含量。方法 以熔融石英毛细管柱(67.4cm×75.0μm,有效长度51.0cm)为分离柱,60mmol/L Na2B4O7,40mmol/L Na2CO3,40mmol/Lβ-环糊精(pH 8.9)为缓冲溶液,检测波长254nm。结果 大黄提取物含量测定中大黄素、大黄酚和大黄酸精密度的相对标准偏差(RSD)分别为1.79%、4.46%和2.30%;3组分共同线性范围为1.1~19.0mg/mL;大黄素、大黄酚和大黄酸的平均回收率分别为100.14%、99.65%和98.44%,RSD分别为2.43%、2.54%和2.02%(n=3)。结论 该方法可用于大黄提取物的含量检测。 展开更多
关键词 电泳 毛细管 大黄 含量测定
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压缩机变频毛细管空气源热泵的实验研究 预览
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作者 牛建会 许树学 +1 位作者 马国远 刘帅领 《制冷与空调(四川)》 2018年第6期590-594,共5页
针对目前我国北方“煤改电”工程中广泛应用的空气源热泵,提出以毛细管作为节流元件,采用变频压缩机的空气源热泵系统。搭建实验装置,实验研究在不同的毛细管长度下,压缩机吸气压力、排气温度及机组制热性能随工况和压缩机频率的变化规... 针对目前我国北方“煤改电”工程中广泛应用的空气源热泵,提出以毛细管作为节流元件,采用变频压缩机的空气源热泵系统。搭建实验装置,实验研究在不同的毛细管长度下,压缩机吸气压力、排气温度及机组制热性能随工况和压缩机频率的变化规律,为优化设计空气源热泵提供参考。 展开更多
关键词 空气源热泵 压缩机变频 毛细管 制热性能
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