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桐乡市社区高血压患者心血管病发病风险评估 预览
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作者 郭丽花 俞敏 +4 位作者 钟节鸣 方乐 陈向宇 王春梅 谢开婿 《预防医学》 2019年第2期124-127,共4页
目的评估桐乡市社区管理的高血压患者心血管病未来10年发病风险,为制定心血管病防制策略提供依据。方法通过桐乡市居民电子健康档案管理系统收集桐乡市社区管理的高血压患者资料,采用《国人缺血性心血管病(ICVD)10年发病风险评估表》评... 目的评估桐乡市社区管理的高血压患者心血管病未来10年发病风险,为制定心血管病防制策略提供依据。方法通过桐乡市居民电子健康档案管理系统收集桐乡市社区管理的高血压患者资料,采用《国人缺血性心血管病(ICVD)10年发病风险评估表》评估ICVD 10年发病风险。结果纳入资料完整的社区管理高血压患者27 173例,其中男性11 868例,占43.68%;女性15 305例,占56.32%。ICVD10年发病风险总分的M (QR)为8.00(3.00)分,男性高血压患者为9.00(2.00)分,高于女性的8.00(2.00)分(P<0.05)。评估ICVD10年发病风险高危8 764例,占32.25%;女性高危比例高于男性(P<0.05)。男性ICVD 10年高危风险因素权重依次为年龄(54.58%)、收缩压(17.42%)、吸烟(14.27%)、体质指数(7.77%)、总胆固醇(4.51%)和糖尿病(1.45%);女性ICVD高危风险因素权重依次为年龄(63.57%)、收缩压(14.63%)、体质指数(9.81%)、总胆固醇(6.00%)、糖尿病(5.88%)和吸烟(0.11%)。结论桐乡市社区管理的高血压患者ICVD10年的风险较高;男性应重点控制血压和吸烟的影响,女性应重点控制血压和体质量的影响。 展开更多
关键词 高血压 心血管病 发病风险 国人缺血性心血管病10年发病风险评估表
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miR-34a在心血管疾病中的作用及机制研究进展
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作者 李晓伟 奉淑君 +2 位作者 周凤华 靳文 赵一俏 《中国动脉硬化杂志》 CAS 2019年第7期624-628,共5页
微小RNA(miR)是心血管疾病发生发展的重要调控因子。其中,miR-34a因广泛参与心血管疾病的病理生理过程成为目前研究热点。在冠状动脉粥样硬化性心脏病等心血管疾病中均存在miR-34a的异常表达。本文就miR-34a对心血管疾病的作用及其机制... 微小RNA(miR)是心血管疾病发生发展的重要调控因子。其中,miR-34a因广泛参与心血管疾病的病理生理过程成为目前研究热点。在冠状动脉粥样硬化性心脏病等心血管疾病中均存在miR-34a的异常表达。本文就miR-34a对心血管疾病的作用及其机制研究进展进行综述,为寻求心血管疾病标志物及治疗靶点提供新思路。 展开更多
关键词 MIR-34A 心血管疾病 冠状动脉粥样硬化性心脏病
Trends of Cardiovascular Mortality in Blacks Africans from Central African City: Hospital Based Study, Brazzaville (Congo) 预览
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作者 Bertrand F. Ellenga-Mbolla Aude Loko-Lemba +5 位作者 Solange F. Mongo-Ngamami Christian M. Kouala-Landa Igor Ondze-Kafata Stephane M. Ikama Thierry R. Gombet Gisèle Kimbally-Kaky 《心血管病(英文)》 2019年第9期698-705,共8页
Background: To determine mortality causes and the associated factors. Patients and Method: This cross-sectional study was conducted from June 2014 to May 2015 (1 year) in the department of cardiology at University and... Background: To determine mortality causes and the associated factors. Patients and Method: This cross-sectional study was conducted from June 2014 to May 2015 (1 year) in the department of cardiology at University and teaching Hospital of Brazzaville. Patients admitted for cardiovascular diseases were included. Patients admitted for cardiovascular disease in other departments of the hospital, or without cardiovascular diseases were not included. Results: In total, 1035 patients, 605 women (5804%) were included. Mean age was 57.1 ± 7 years (range: 18 - 85 years). The patients were: elderly (n = 498, 48.1%), educated (n = 809, 78.1%), low-income (n = 253, 24.2%). The medical history of patients was: hypertension (n = 440, 42.5%), diabetes (n = 316, 30.5%), reduced physical activity (n = 154, 14.9%), excessive alcohol intake (n = 56, 5.4%). Heart failure was reported in 386 cases (37.3%). The mortality rate was 8% (n = 83);the mean age of deceased was 61.9 ± 7.3 years (p s in death were dilated cardiomyopathy (n = 37, 44.6%, OR 5, 95%CI 3.1 - 8, p -3.3, p = 0.002), atrial fibrillation (n = 24, 29%, OR 3.6, 95%CI 2.2 - 6, p - 9.8, p = 0.005). The associated death comorbidities were: acute respiratory infection (n = 44, 53%, OR 10.1, 95%CI 6.2 - 16, p - 10 p - 6.8, p Conclusion: Hypertension, heart failure and cardiomyopathies are the leading causes of mortality in the department of cardiology. Prevention and patient education in a low-income environment are essential elements to reduce this morbidity. 展开更多
关键词 MORTALITY CARDIOVASCULAR Disease BLACKS AFRICANS Sub-Saharan Africa
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In Defense of the LDL Hypothesis 预览
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作者 David S. Schade Lynda Shey R. Philip Eaton 《心血管病(英文)》 2019年第3期245-252,共8页
Both clinical and basic science studies during the last 30 years have emphasized the importance of cholesterol in the pathogenesis of atherosclerosis. There is a direct relationship between the level of circulating ch... Both clinical and basic science studies during the last 30 years have emphasized the importance of cholesterol in the pathogenesis of atherosclerosis. There is a direct relationship between the level of circulating cholesterol (as LDLc remnant particles) and the incidence of cardiovascular events. However, this hypothesis has not gone unchallenged, both in social media and the scientific literature. This controversy has major consequences to the health of the public,?because atherosclerosis is the number one cause of morbidity and mortality in the Western World.?The proponents of the non-importance of atherosclerosis base their argument on certain studies. We have carefully examined these studies in order to address the validity of the challenges.?Each of these studies has its own deficiencies?as pointed out in this article. Overall, the evidence that cholesterol is not the primary underlying pathogenic factor causing heart attacks and strokes is based on a flawed interpretation of study results. These studies have several serious deficiencies including lost data, inadequate power, excessive drop outs, borderline significance, and lack of a control group. The conclusion that cholesterol is essential in the pathogenesis of atherosclerosis is critical for treating and preventing atherosclerosis and reducing the prevalence of cardiovascular disease. 展开更多
关键词 ATHEROSCLEROSIS CHOLESTEROL LDL CHOLESTEROL Study Design STATINS CARDIOVASCULAR Disease
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深圳市南山区慢病重点监测人群心血管健康指标分析
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作者 马剑平 戴舒红 +5 位作者 彭晓琳 徐珊 陈洪恩 张春惠 韩丽媛 王长义 《中国公共卫生》 CAS CSCD 北大核心 2019年第5期626-629,共4页
目的对深圳市南山区慢病重点监测人群的心血管健康指标进行现况分析。方法通过问卷调查以及现场测量的方式对2017年深圳市南山区社区慢病重点监测人群共9113人的心血管健康指标进行收集与分析,采用χ2检验以及logistic回归分析进行统计... 目的对深圳市南山区慢病重点监测人群的心血管健康指标进行现况分析。方法通过问卷调查以及现场测量的方式对2017年深圳市南山区社区慢病重点监测人群共9113人的心血管健康指标进行收集与分析,采用χ2检验以及logistic回归分析进行统计分析。结果心血管健康指标评分达到5~6分的占7.79%。人群吸烟达到健康指标的占比最高,占84.98%,血压达到健康指标的占比最低,占14.36%。以心血管健康指标评分为5~6分为参照,心血管健康指标评分越低,高血压、糖尿病以及高血压伴随糖尿病危险性越高。结论人群心血管指标达到理想状态的比例较低。南山区慢病重点监测人群吸烟状况处于良好水平,但血压控制和体育锻炼需要作为重点管理目标。 展开更多
关键词 慢性病 心血管健康指标 心血管疾病
The Rationale for a Different Approach to Preventing Cardiovascular Disease 预览
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作者 David S. Schade Barry Ramo +2 位作者 S. Scott Obenshain Ron Schrader R. Philip Eaton 《心血管病(英文)》 2019年第7期489-510,共22页
The Problem: We have previously suggested that an alternative approach to preventing cardiovascular disease is necessary because atherosclerotic cardiovascular disease (ASCVD) has been increasing for the last 50 years... The Problem: We have previously suggested that an alternative approach to preventing cardiovascular disease is necessary because atherosclerotic cardiovascular disease (ASCVD) has been increasing for the last 50 years and has now reached epidemic status. Since the year 2000, approximately 600,000 heart attacks and ASCVD related deaths have occurred annually in the United States. It is the most common cause of death in the U.S., more than all cancers combined. The financial costs are staggering, amounting to 555 billion dollars per year in direct and indirect costs. Outlook for an improvement in these statistics is not encouraging as the U.S. population continues to become more obese and to develop diabetes. The Question: Why is ASCVD continuing to be a major challenge to healthcare providers when the pathogenesis is known and inexpensive preventative treatment is available? The reasons are multiple and complex. First, present financial reimbursement policies of healthcare organizations reward treatment of a disease and its complications instead of preventing the disease. Second, professional guidelines and treatment goals are often too complex, subject to interpretation, and time-consuming to be useful in the clinical setting. Third, no specific follow-up of patients at risk for ASCVD is recommended when the risk assessment changes. Fourth, many expensive cardiovascular diagnostic tests are utilized without meeting appropriate guidelines for their use. Fifth, treatment of individuals without first proving the presence of disease results in poor adherence to therapy. The Solution: This article describes the rationale for a new approach to the prevention of ASCVD in asymptomatic individuals. It is based upon preventing ASCVD by identifying all asymptomatic individuals with subclinical disease before an ASCVD event occurs. It recommends that all adults be screened for ASCVD on or before the age of 50 using a non-invasive atherosclerosis specific coronary artery calcium heart scan. Further recommendations include tre 展开更多
关键词 CARDIOVASCULAR DISEASE Preventing ASCVD
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Relationship between Selected Risk Factors for Cardiovascular Diseases and the Quality of Life 预览
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作者 Rita Nkechi Ativie Uzoma Emmanuella Onah 《康复医学(英文)》 2019年第3期106-119,共14页
The ageing population is more predisposed to chronic diseases and functional disabilities with an increased level of dependence. The delivery of adequate health care services to the ageing population requires enquires... The ageing population is more predisposed to chronic diseases and functional disabilities with an increased level of dependence. The delivery of adequate health care services to the ageing population requires enquires into their quality of life. This cross-sectional study therefore investigated the relationship between some selected risk factors for cardiovascular diseases (CVD) and the quality of life of aging adults. Using a convenient sampling technique, one hundred and forty six (146) adults of ages 50 years and above from varying locations within the Metropolis of Enugu State, Nigeria were recruited. The parameters obtained were participants’ blood pressure, height, body weight, waist circumference and blood sugar level. Health-related quality of life was assessed using the WHO-QOL BREF and physical activity level was assessed with the IPAQ. Data were summarized using descriptive statistics of frequency and percentage while the statistical measures of relationship (Pearson’s moment correlation and spearman rho correlation) were used to calculate the relationship between obtained data. The result revealed a positive relationship between waist circumference (obesity indicator) and the environment domain of quality of life measure (r = 0.227, p = 0.006). Surprisingly, no relationship was found between obesity indicators (waist circumference and BMI) and physical/psychological health status. The result also found a positive relationship between physical activity levels and quality of life;a weak negative relationship between casual blood sugar levels and the social relationship domains of quality of life and a weak negative relationship was also observed between age and physical activity and psychological health. Therefore, reduced physical activity level influences a poor quality of life. We recommend physical activity participation among the older population, as well as detailed similar studies for higher degree of certainty. 展开更多
关键词 CARDIOVASCULAR Disease Quality of LIFE RISK FACTORS Ageing
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Is Intimate Partner Violence a Risk Factor for Cardiovascular Disease in Women? A Review of the Preponderance of the Evidence 预览
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作者 Rose Eva Constantino Alona D. Angosta +8 位作者 Andrew Thomas Reyes Brayden Kameg Linden Wu Jordan Cobb Vivian Hui Daisy Palompon Reema Safadi Mayada Daibes Elizabeth Schlenk 《健康(英文)》 2019年第6期841-854,共14页
This paper examines the relationship between intimate partner violence (IPV) experience in women and cardiovascular disease (CVD), and determines if there is a preponderance of literature evidence. Research is reviewe... This paper examines the relationship between intimate partner violence (IPV) experience in women and cardiovascular disease (CVD), and determines if there is a preponderance of literature evidence. Research is reviewed dealing with the different biopsychosocial factors affecting the relationship between IPV and CVD. As a result of our review, we propose a framework on the biopsychosocial pathway of IPV as a risk factor of CVD of women. Our proposed framework portrays how IPV experiences contribute to long-term biopsychosocial changes that increase the risk of CVD among female victims of IPV. These biopsychosocial changes include chronic inflammation and hypothalamus-pituitary-adrenal axis dysfunction, metabolic or endocrine dysfunction, and mood symptomatology. In our framework, we also included strategies to prevent risks in developing CVD through the three levels of prevention. Because gender disparities exist when examining CVD risk and development, the correlation between IPV and CVD risk in women must be explored. This framework may provide a theoretical foundation for further research on the relationship between IPV and CVD among women. 展开更多
关键词 INTIMATE PARTNER VIOLENCE CARDIOVASCULAR Disease WOMEN
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能量代谢紊乱对疾病的影响及其潜在药物靶点
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作者 张宝月 刘艾林 杜冠华 《药学学报》 CAS CSCD 北大核心 2019年第8期1372-1381,共10页
营养物质利用障碍和线粒体损伤导致的细胞能量代谢紊乱与多种疾病密切相关,包括神经退行性疾病、癌症、代谢性疾病和心血管疾病等,了解能量代谢对疾病的影响将有助于加深对疾病的认识并可能通过改善能量代谢途径延缓疾病进程或者达到治... 营养物质利用障碍和线粒体损伤导致的细胞能量代谢紊乱与多种疾病密切相关,包括神经退行性疾病、癌症、代谢性疾病和心血管疾病等,了解能量代谢对疾病的影响将有助于加深对疾病的认识并可能通过改善能量代谢途径延缓疾病进程或者达到治愈的目的。本文主要综述了常见的能量代谢紊乱相关疾病异常的能量代谢现象,并总结了可能用于新药发现的相关靶点和机制,以及目前在研的通过改善能量代谢缓解疾病进程的新策略。 展开更多
关键词 能量代谢 新药发现 潜在靶点 神经退行性疾病 癌症 代谢性疾病 心血管疾病
Stable Ischemic Heart Disease in the Older Adult 预览
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作者 Juan R.Vilaro 《心血管创新与应用》 2019年第B01期291-296,共6页
Demographic trends worldwide show a progressively aging population and an increase in the overall medical complexity of elderly patients with cardiovascular disease.Elderly patients,especially those aged 75 or older,a... Demographic trends worldwide show a progressively aging population and an increase in the overall medical complexity of elderly patients with cardiovascular disease.Elderly patients,especially those aged 75 or older,are relatively underrepresented in many of the clinical trials that helped create major society guidelines for evaluation and management of ischemic heart disease.Consequently,risk benefi t ratios of a guideline-based approach in these patients are not well defi ned,especially with regards to pharmacotherapies and percutaneous coronary interventions.In this article we offer a practical approach to defi ning the elderly population,and provide an evidenced based review of the diagnostic and therapeutic implications of advanced age in the evaluation and management of ischemic heart disease. 展开更多
关键词 ELDERLY ISCHEMIC heart DISEASE CORONARY artery DISEASE OLDER adult CARDIOVASCULAR DISEASE
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半乳糖凝集素-3在相关疾病中的研究进展 预览
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作者 丁婧 陈晖 《循证医学》 2019年第2期112-118,共7页
半乳糖凝集素-3是半乳糖凝集素家族中的重要一员,其在许多病理生理过程中发挥作用,例如炎症反应、纤维化、细胞增殖及凋亡、血管生成、免疫反应等。越来越多的证据表明半乳糖凝集素-3参与了多种疾病的发生发展,本文就其在相关疾病中的... 半乳糖凝集素-3是半乳糖凝集素家族中的重要一员,其在许多病理生理过程中发挥作用,例如炎症反应、纤维化、细胞增殖及凋亡、血管生成、免疫反应等。越来越多的证据表明半乳糖凝集素-3参与了多种疾病的发生发展,本文就其在相关疾病中的研究进展作一综述,以期为临床治疗提供依据。 展开更多
关键词 半乳糖凝集素-3 心血管疾病 呼吸系统疾病 慢性肾脏疾病 肿瘤
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冠心病PCI术后二级预防现状 预览
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作者 邹晓鸿 邓雯予 王海琴 《世界最新医学信息文摘》 2019年第73期29-30,共2页
冠心病发病率逐年上升,已成为严重危害人类健康、影响人们生活质量最常见的心血管疾病之一。经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)是解决冠脉内严重狭窄,改善心肌缺血并降低由此造成的急慢性心血管事件发生的... 冠心病发病率逐年上升,已成为严重危害人类健康、影响人们生活质量最常见的心血管疾病之一。经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)是解决冠脉内严重狭窄,改善心肌缺血并降低由此造成的急慢性心血管事件发生的主要治疗手段。目前Pci术后支架内再狭窄、主要心血管不良事件(Major adverse cardiovascular events,MACE)高发。本文对Pci术后患者二级预防国内外现状进行综述。 展开更多
关键词 冠心病 心血管疾病 高血压合并冠心病 糖尿病患者冠脉支架
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针灸调节内质网应激的研究进展 被引量:1
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作者 赵华 蒋洁 《针刺研究》 CAS CSCD 北大核心 2019年第1期75-78,F0003共5页
内质网(ER)是蛋白质修饰、折叠和Ca^2+贮存的场所,ER内稳态失衡时,即发生内质网应激(ERS)。ERS及其诱导的凋亡与许多疾病的发生发展密切相关。针灸能够影响细胞ERS以及细胞凋亡因子的表达而调节ERS。本文综述了近5年针灸调节神经系统疾... 内质网(ER)是蛋白质修饰、折叠和Ca^2+贮存的场所,ER内稳态失衡时,即发生内质网应激(ERS)。ERS及其诱导的凋亡与许多疾病的发生发展密切相关。针灸能够影响细胞ERS以及细胞凋亡因子的表达而调节ERS。本文综述了近5年针灸调节神经系统疾病、糖尿病、心血管疾病、非酒精性脂肪肝等相关疾病细胞ERS的研究进展,为阐释针灸防治相关疾病的可能机制提供参考。 展开更多
关键词 内质网应激 针灸 神经系统疾病 糖尿病 心血管疾病 非酒精性脂肪肝
心血管植入式电子器械与三尖瓣反流加重的影响因素 预览
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作者 史成龙 张海青 +3 位作者 苑洪涛 黄亚 张玉霄 卢才义 《中华老年多器官疾病杂志》 2019年第3期180-184,共5页
目的探讨心血管植入式电子器械(CIEDs)患者三尖瓣反流加重的影响因素及可能的发生机制。方法回顾性收集解放军总医院第一医学中心心血管内科2014年1月至2016年12月所有植入CIEDs(单腔或双腔永久式起搏器、埋藏式心律转复除颤器及心脏再... 目的探讨心血管植入式电子器械(CIEDs)患者三尖瓣反流加重的影响因素及可能的发生机制。方法回顾性收集解放军总医院第一医学中心心血管内科2014年1月至2016年12月所有植入CIEDs(单腔或双腔永久式起搏器、埋藏式心律转复除颤器及心脏再同步化治疗)后复查心脏彩超的198例患者的临床资料。根据术后三尖瓣反流是否加重分为三尖瓣反流未加重组146例和加重组52例,比较2组患者的临床资料及术前心脏彩超资料。采用SPSS17.0软件对数据进行统计学处理。组间比较采用Mann-WhitneyU检验、非配对χ^2检验或Fisher精确概率法。采用多因素logistic逐步回归法分析三尖瓣反流加重的相关危险因素。结果与未加重组比较,加重组患者男性、术前肌酐清除率、高脂血症及植入时间>12个月的的患者比例升高,术前右心房内径较小、二尖瓣及三尖瓣存在反流的患者比例较低,差异有统计学意义(P<0.05)。多因素logistic回归分析表明,植入时间(OR=1.000,95%CI1.001~1.003;P=0.013)和高脂血症(OR=2.024,95%CI6.728~22.360;P=0.022)可能是三尖瓣反流加重的独立危险因素;术前存在轻度三尖瓣反流(OR=0.018,95%CI0.049~0.133;P<0.001)可能是三尖瓣反流加重的独立保护因素。结论起搏器植入时间、高脂血症可加重三尖瓣反流,术前三尖瓣反流程度与术后三尖瓣反流加重相关,应注意随访观察。 展开更多
关键词 心血管植入式电子装置 三尖瓣反流 心血管病
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心血管系统的家庭监测技术现状及其研究展望 预览
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作者 曲晓威 陆思宇 +1 位作者 张彤 宋义林 《黑龙江大学工程学报》 2019年第2期63-70,共8页
心血管疾病已成为我国因病致死的头号病因。心血管循环系统(简称心血管系统)的家庭医疗监测对心血管疾病的早发现、早诊断、早治疗具有重要意义。心血管系统的生理参数主要包括血压、心输出量、血糖含量、血氧饱和度以及心电、呼吸等。... 心血管疾病已成为我国因病致死的头号病因。心血管循环系统(简称心血管系统)的家庭医疗监测对心血管疾病的早发现、早诊断、早治疗具有重要意义。心血管系统的生理参数主要包括血压、心输出量、血糖含量、血氧饱和度以及心电、呼吸等。这些生理参数需要长时间的日常监测,才能发现系统的异常及变化。因此,家庭医疗监测是必要的。述评了近年来心血管系统主要参数的家庭监测技术现状,对其未来的研究趋势进行了展望。 展开更多
关键词 心血管系统 心血管疾病 家庭监测 医疗仪器 研究展望
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Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence 预览
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作者 Leonardo Pozo Fatimah Bello +4 位作者 Andres Suarez Francisco E Ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani 《世界糖尿病杂志:英文版(电子版)》 2019年第5期291-303,共13页
Cardiovascular diseases (CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus (T2DM) suffer from both microvascular and macrovascular diseases an... Cardiovascular diseases (CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus (T2DM) suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration (FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and, in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon like peptide-1 receptor agonists (GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular (CV) events in patients with T2DM and established CV disease. SGLT2i have been shown to have a stronger benefit in patients with congestive heart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD. 展开更多
关键词 Type 2 diabetes mellitus Glucagon-like-peptide 1 AGONISTS Sodium-glucose cotransporter-2 inhibitor CARDIOVASCULAR disease Major ADVERSE CARDIOVASCULAR event
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Prevention of macrovascular complications in patients with type 2 diabetes mellitus: Review of cardiovascular safety and efficacy of newer diabetes medications 预览
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作者 Ravi Kant Kashif M Munir +1 位作者 Arshpreet Kaur Vipin Verma 《世界糖尿病杂志:英文版(电子版)》 2019年第6期324-332,共9页
Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized cont... Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician’s armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors. 展开更多
关键词 Newer antidiabetic MEDICATIONS Glucagon-like peptide-1 receptor agonist Sodium-glucose cotransporter-2 inhibitors Type 2 DIABETES MELLITUS Macrovascular complications CARDIOVASCULAR outcome trials Major CARDIOVASCULAR events HEART failure PREVENTION of HEART disease
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新型APJ配体-肽类激素Elabela在心血管系统中的研究进展 预览
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作者 黄思慧 唐其柱 《中国医药导报》 CAS 2019年第15期25-28,共4页
Elabela是一种新型的内源性血管紧张素受体AT1相关受体蛋白(APJ)配体,早期研究认为其主要表达于胚胎组织中,但近年来的研究发现作为一种内源性激素,Elabela在胚胎发育之后同样表达于心脏血管等组织器官中。APJ在哺乳动物心血管系统中发... Elabela是一种新型的内源性血管紧张素受体AT1相关受体蛋白(APJ)配体,早期研究认为其主要表达于胚胎组织中,但近年来的研究发现作为一种内源性激素,Elabela在胚胎发育之后同样表达于心脏血管等组织器官中。APJ在哺乳动物心血管系统中发挥调控作用,而作为APJ配体之一的Elabela同样在心血管系统中有着重要作用。本文主要探讨Elabela在心血管发育及心血管疾病中的作用及其临床应用前景。 展开更多
关键词 Elabela APJ配体 心血管系统 心血管疾病
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血脂康降脂以外的心血管保护作用及机制研究进展
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作者 奉淑君 唐欣颖 +1 位作者 王瑛 匡泽民 《中国新药杂志》 CAS CSCD 北大核心 2019年第10期1192-1196,共5页
心血管疾病是全球"头号杀手",其主要病理基础是动脉粥样硬化。血脂康以特制红曲为原料,对改善动脉粥样硬化具有积极意义。血脂康除能安全、有效降低血脂外,近年来其降脂以外的心血管获益也备受关注。研究表明,血脂康通过调节... 心血管疾病是全球"头号杀手",其主要病理基础是动脉粥样硬化。血脂康以特制红曲为原料,对改善动脉粥样硬化具有积极意义。血脂康除能安全、有效降低血脂外,近年来其降脂以外的心血管获益也备受关注。研究表明,血脂康通过调节内皮功能、保护内皮祖细胞、改善氧化应激和减轻炎症反应等多种机制发挥抗动脉粥样硬化作用,本文从以上几方面综述血脂康抗动脉粥样硬化、心血管保护的研究进展。 展开更多
关键词 血脂康 心血管疾病 心血管获益 动脉粥样硬化 分子机制
重庆某三甲医院恶性肿瘤住院患者伴心血管疾病的流行病学特征分析
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作者 雷海科 李小升 +6 位作者 刘海霞 龙波 罗敏 王璐璐 赵玉兰 周宏 张维 《肿瘤预防与治疗》 2019年第10期900-905,共6页
目的:分析2014~2018年重庆某三甲医院恶性肿瘤住院患者伴心血管疾病的构成情况,探讨恶性肿瘤与心血管疾病的关系,为恶性肿瘤合并心血管疾病的防治措施的制定提供科学依据。方法:回顾性分析2014~2018年间重庆市某三甲医院收治的新发恶性... 目的:分析2014~2018年重庆某三甲医院恶性肿瘤住院患者伴心血管疾病的构成情况,探讨恶性肿瘤与心血管疾病的关系,为恶性肿瘤合并心血管疾病的防治措施的制定提供科学依据。方法:回顾性分析2014~2018年间重庆市某三甲医院收治的新发恶性肿瘤患者,使用医院信息系统提取患者的年龄、性别、治疗方式,TNM分期等信息,采用国际疾病分类ICD-10编码,对出院诊断进行归类,同时利用身份证号进行剔重,统计分析住院治疗的新发恶性肿瘤患者合并心血管疾病的情况。结果:5年共收治11 620例新发恶性肿瘤患者,平均年龄(61. 17±12. 52)岁。其中合并心血管疾病诊断的有4 897人,占42. 14%,平均年龄(65. 82±10. 85)岁;不同年份收治的新发恶性肿瘤患者中合并心血管疾病的比例差异有统计学意义(χ^2=1 436. 691,P <0. 001),其中2018年共有1 322例患者合并心血管疾病,占28. 59%;不同年龄段患者合并心血管的比例差异有统计学意义(χ^2=1 118. 635,P <0. 001),其中大于等于66岁患者合并心血管疾病的人数最多,共计2 571例(占58. 13%);不同治疗方式的患者合并心血管疾病的比例差异有统计学意义(χ^2=237. 519,P <0. 001),其中单纯放、化疗的患者合并心血管疾病的比例相对较高;不同TNM分期的患者合并心血管疾病的比例差异有统计学意义(χ2=94. 271,P <0. 001),其中分期越晚的患者合并心血管疾病的比例越大;不同性别、民族、婚姻状况的患者合并心血管疾病的比例差异无统计学意义。结论:未来肿瘤合并心血管疾病的人群基数会越来越大,更多的肿瘤患者需要在治疗肿瘤的同时兼顾心血管疾病的治疗,尽量避免抗肿瘤治疗引发的心血管毒性。 展开更多
关键词 恶性肿瘤 心血管疾病 住院患者 流行病学 心血管毒性
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