期刊文献+
共找到106,431篇文章
< 1 2 250 >
每页显示 20 50 100
Advances in diabetic microvascular complications and related molecular mechanisms
1
作者 Gang Zeng Qun-Fang Ding 《海南医科大学学报(英文版)》 2019年第1期83-86,共4页
With the change of production and life style, the change of dietary structure and the aggravation of population aging, the incidence and fatality rate of diabetes mellitus have been increasing year by year. The pathog... With the change of production and life style, the change of dietary structure and the aggravation of population aging, the incidence and fatality rate of diabetes mellitus have been increasing year by year. The pathogenesis of diabetes varies and is closely related to many factors, such as genetic factors, environmental factors, eating habits and so on. Those that endanger the life quality and survival of diabetic patients are mostly complications, including various macrovascular complications and microvascular complications, such as diabetic cardiomyopathy, diabetic nephropathy, diabetic encephalopathy and diabetic foot. The related molecular mechanisms of the pathogenesis of diabetic nephropathy, diabetic retinopathy and diabetic foot are discussed in this paper to provide reference for new drug research and clinical treatment. 展开更多
关键词 Diabetes COMPLICATIONS MICROVASCULAR COMPLICATIONS DIABETIC NEPHROPATHY DIABETIC FOOT DIABETIC RETINOPATHY
Evolving spectrum of diabetic nephropathy 预览
2
作者 Jonathan Kopel Camilo Pena-Hernandez Kenneth Nugent 《世界糖尿病杂志:英文版(电子版)》 2019年第5期269-279,共11页
Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy (DN), which classically presents with proteinuria followed by a progressive decrease in r... Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy (DN), which classically presents with proteinuria followed by a progressive decrease in renal function. However, an increasing proportion of DN patients have a decline in kidney function and vascular complications without proteinuria, known as nonproteinuric DN (NP-DN). Despite the increased incidence of NP-DN, few clinical or experimental studies have thoroughly investigated the pathophysiological mechanisms and targeted treatment for this form of DN. In this review, we will examine the differences between conventional DN and NP-DN and consider potential pathophysiological mechanisms, diagnostic markers, and treatment for both DN and NP-DN. The investigation of the pathophysiology of NP-DN should provide additional insight into the cardiovascular factors influencing renal function and disease and provide novel treatments for the vascular complications seen in diabetic patients. 展开更多
关键词 DIABETIC NEPHROPATHY Non-proteinuric DIABETIC NEPHROPATHY Diabetes Kidney VASCULAR COMPLICATIONS
在线阅读 免费下载
Early vs late oral nutrition in patients with diabetic ketoacidosis admitted to a medical intensive care unit 预览
3
作者 Kirill Lipatov Kevin K Kurian +4 位作者 Courtney Shaver Heath D White Shekhar Ghamande Alejandro C Arroliga Salim Surani 《世界糖尿病杂志:英文版(电子版)》 2019年第1期57-62,共6页
BACKGROUND Diabetic ketoacidosis(DKA)has an associated mortality of 1%to 5%.Upon admission,patients require insulin infusion and close monitoring of electrolyte and blood sugar levels with subsequent transitioning to ... BACKGROUND Diabetic ketoacidosis(DKA)has an associated mortality of 1%to 5%.Upon admission,patients require insulin infusion and close monitoring of electrolyte and blood sugar levels with subsequent transitioning to subcutaneous insulin and oral nutrition.No recommendations exist regarding the appropriate timing for initiation of oral nutrition.AIM To assess short-term outcomes of oral nutrition initiated within 24 h of patients being admitted to a medical intensive care unit(MICU)for DKA.METHODS A retrospective observational cohort study was conducted at a single academic medical center.The patient population consisted of adults admitted to the MICU with the diagnosis of DKA.Baseline characteristics and outcomes were compared between patients receiving oral nutrition within(early nutrition group)and after(late nutrition group)the first 24 h of admission.The primary outcome was 28-d mortality.Secondary outcomes included 90-d mortality,MICU and hospital lengths of stay(LOS),and time to resolution of DKA.RESULTS There were 128 unique admissions to the MICU for DKA with 67 patients receiving early nutrition and 61 receiving late nutrition.The APACHE(Acute Physiology and Chronic Health Evaluation)IV mortality and LOS scores and DKA severity were similar between the groups.No difference in 28-or 90-d mortality was found.Early nutrition was associated with decreased hospital and MICU LOS but not with prolonged DKA resolution,anion gap closure,or greater rate of DKA complications.CONCLUSION In patients with DKA,early nutrition was associated with a shorter MICU and hospital LOS without increasing the rate of DKA complications. 展开更多
关键词 Diabetes MELLITUS DIABETIC KETOACIDOSIS DIABETIC complications ACIDOSIS KETOSIS Critical care
在线阅读 免费下载
Prevalence of diabetic retinopathy, proliferative diabetic retinopathy and non-proliferative diabetic retinopathy in Asian T2DM patients: a systematic review and Metaanalysis
4
作者 Qian-Hui Yang Yan Zhang +1 位作者 Xiao-Min Zhang Xiao-Rong Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第2期302-311,共10页
AIM:To investigate the pooled prevalence of diabetic retinopathy(DR), proliferative DR(PDR) and nonproliferative DR(NPDR) in Asian type 2 diabetes mellitus(T2 DM) patients. METHODS:We performed a systematic search onl... AIM:To investigate the pooled prevalence of diabetic retinopathy(DR), proliferative DR(PDR) and nonproliferative DR(NPDR) in Asian type 2 diabetes mellitus(T2 DM) patients. METHODS:We performed a systematic search online search using PubMed, EMBASE, Web of Science, the Cochrane Library, and China WeiPu Library to identify eligible studies that reported the prevalence of DR, PDR and NPDR in Asian T2 DM patients. Effect size(ES) with 95% confidence interval(CI) was used to evaluate the prevalence of DR, PDR and NPDR in Asian T2 DM patients, respectively. RESULTS:There were 41 references and 48 995 T2 DM patients involved in this study. The prevalence of DR, PDR, and NPDR was 28%, 6%, and 27% in T2 DM patients, respectively;while the prevalence of PDR and NPDR in DR patients was 17% and 83%, respectively. Subgroup analysis showed that prevalence of DR in T2 DM patients from Singaporean, Indian, South Korean, Malaysian, Asian, and Chinese was 33%, 42%, 16%, 35%, 21% and 25%, respectively. In T2 DM patients with NPDR from Indian, South Korean, Malaysian, Asian, Chinese, higher prevalence was found than that in PDR patients(45% vs 17%, 13% vs 3%, 30% vs 5%, 23% vs 2% and 22% vs 3%), as well as in DR patients(74% vs 26%, 81% vs 19%, 86% vs 14%, 92% vs 8% and 85% vs 15%). The prevalence of PDR in T2 DM from India was higher than patients fromother locations of Asia, and the same results were also observed in NPDR patients. CONCLUSION:In either T2 DM Asian patients or DR patients, NPDR is more common than PDR. Based on our results, we should pay more attention to NPDR screening and management in T2 DM patients, and we also recommend suitable interventions to prevent its progression. 展开更多
关键词 PREVALENCE PROLIFERATIVE DIABETIC RETINOPATHY nonproliferative DIABETIC RETINOPATHY ASIAN type 2 diabetes MELLITUS
Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy
5
作者 Keitaro Hase Atsuhiro Kanda +1 位作者 Kousuke Noda Susumu Ishida 《国际眼科杂志:英文版》 SCIE CAS 2019年第4期692-694,共3页
Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, ... Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, rather than its specific receptors. 展开更多
关键词 INCREASED plasma GALECTIN-1 CORRELATES with advanced glycation end products and INTERLEUKIN-1Β in patients with proliferative DIABETIC RETINOPATHY DIABETIC RETINOPATHY
Vascular endothelial dysfunction, cardiomyopathy a major mediator in diabetic cardiomyopathy
6
作者 Maura Knapp Xin Tu Rongxue Wu 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第1期1-8,共8页
Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic pa... Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients.While ischemic events are commonly observed in diabetic patients,the risk for developing heart failure is also increased,independent of the severity of coronary artery disease and hypertension.This diabetes-associated clinical entity is considered a distinct disease process referred to as "diabetic cardiomyopathy".However,it is not clear how diabetes promotes cardiac dysfunction.Vascular endothelial dysfunction is thought to be one of the key risk factors.The impact of diabetes on the endothelium involves several alterations,including hyperglycemia,fatty acid oxidation,reduced nitric oxide (NO),oxidative stress,inflammatory activation,and altered barrier function. The current review provides an update on mechanisms that specifically target endothelial dysfunction,which may lead to diabetic cardiomyopathy. 展开更多
关键词 CARDIOMYOPATHY diabetes DIABETIC CARDIOVASCULAR COMPLICATIONS ENDOTHELIUM vascular heart failure metabolism
术中前房注射曲安奈德在糖尿病性白内障中的应用 预览
7
作者 金伟平 蒲柳艳 《中国现代医生》 2019年第12期81-84,共4页
目的探讨术中前房注射曲安奈德在糖尿病性白内障中的应用。方法选取2012年1月~2018年2月眼科住院治疗的糖尿病性白内障患者72例(72眼),知情同意后采用抛硬币法分成曲安奈德组(n=36)和对照组(n=36)。两组均在在表面麻醉下行超声乳化白内... 目的探讨术中前房注射曲安奈德在糖尿病性白内障中的应用。方法选取2012年1月~2018年2月眼科住院治疗的糖尿病性白内障患者72例(72眼),知情同意后采用抛硬币法分成曲安奈德组(n=36)和对照组(n=36)。两组均在在表面麻醉下行超声乳化白内障联合人工晶状体植入术,曲安奈德组术中侧切口注入1mg曲安奈德和复方平衡盐溶液以维持前房。对照组按常规方法注入复方平衡盐溶液以形成维持前房。观察并比较两组术后角膜水肿、瞳孔粘连、前房纤维蛋白渗出及后囊浑浊的发生率。结果曲安奈德组术后角膜水肿发生率低于对照组(χ2=4.50,P<0.05)。两组术后瞳孔粘连发生率相接近(χ2=0.26,P>0.05)。曲安奈德组术后前房轻、中、重度渗出总发生率低于对照组(χ2=6.77,P<0.01)。曲安奈德组术后后囊浑浊的发生率低于对照组(χ2=4.13,P<0.05)。结论术中前房注射曲安奈德在糖尿病性白内障中的应用效果较确切,能显著减轻术后角膜水肿和前房纤维蛋白渗出,降低后囊浑浊的发生率。 展开更多
关键词 白内障 糖尿病性 前房 曲安奈德
在线阅读 下载PDF
Relationship between different healing degree and C peptide in elderly patients with diabetic foot ulcers
8
作者 Lin Qu Ya-Li Zhou +1 位作者 Teng Zhou Yan-Hu Dong 《海南医科大学学报(英文版)》 2019年第4期50-55,共6页
Objective:To explore the relationship between different healing degree and C peptide in elderly patients with diabetic foot ulcers.Methods:Totally, two hundred and forty-one DFU patients were selected into our researc... Objective:To explore the relationship between different healing degree and C peptide in elderly patients with diabetic foot ulcers.Methods:Totally, two hundred and forty-one DFU patients were selected into our research from September 2nd, 2011 to September 2nd, 2012. After admission, the patients' sex, age, the course of diabetes, the days of hospitalization, and BMI were recorded. After examination, blood routine and blood biochemistry, urine routine, hepatorenal work were recorded. Follow up 5 years, patients with unhealed ulcers were selected into bad prognosis group during follow-up, and patients with ulcerative healing into good prognosis group. Single factor analysis showed factors affecting the healing of DFU patients;Cox proportional risk model was further evaluated the effect of all factors with statistical significance on the healing of DFU patients. Using the ROC curve to analyze the statistically significant factors and to calculate the area under the curve to evaluate the predictive ability of the healing of the patients with DFU.Results: At the end of the follow-up, 6 patients were lost, 177 had the end point, and the healing rate was 73.44%. Single factor and multifactor analysis showed that the course of diabetes and HbA1C were independent risk factors affecting the prognosis. FCP was an independent protective factor affecting the prognosis. In ROC, the AUC of diabetes course was 0.754 under the ROC curve. The AUC of HbA1C under the line is 0.791, while the AUC of FCP level is 0.581 under the ROC curve.Conclusion: Low FCP is an independent risk factor for DFU healing, but FCP has little predictive effect on patient healing. 展开更多
关键词 DIABETIC FOOT C PEPTIDE OLD age HEALING
毛果鱼藤石油醚提取物对2型糖尿病小鼠炎性因子及血脂的影响
9
作者 杨立芳 邓丽姚 +4 位作者 姜明国 黄仁彬 韦炎冶 石松标 陈兆霓 《中药材》 CAS 北大核心 2019年第1期169-173,共5页
目的:研究毛果鱼藤石油醚提取物对2型糖尿病小鼠炎性因子及血脂的影响。方法:使用尾静脉注射链脲佐菌素辅以高糖高脂饲料建立2型糖尿病小鼠模型,给予模型小鼠不同剂量的药物,给药时间为21 d。给药结束后检测小鼠血清胰岛素、胰岛素敏感... 目的:研究毛果鱼藤石油醚提取物对2型糖尿病小鼠炎性因子及血脂的影响。方法:使用尾静脉注射链脲佐菌素辅以高糖高脂饲料建立2型糖尿病小鼠模型,给予模型小鼠不同剂量的药物,给药时间为21 d。给药结束后检测小鼠血清胰岛素、胰岛素敏感指数(ISI)、总胆固醇(TG)、甘油三酯(TC)、高密度脂蛋白胆固醇(HDL-C)、单核细胞趋化蛋白-1(MCP-1)、白介素-1β(IL-1β)的含量;使用RT-PCR和Western blot法检测毛果鱼藤石油醚提取物对2型糖尿病小鼠肝脏TLR-4、NF-κB、Caspase-3 mRNA及蛋白表达的影响。结果:毛果鱼藤石油醚提取物能有效提高糖尿病小鼠血清胰岛素、ISI、HDL-C水平;显著降低糖尿病小鼠血清TC、TG、IL-1β、MCP-1含量;下调TLR-4、NF-κB、Caspase-3 mRNA及蛋白在肝脏中的表达。结论:毛果鱼藤石油醚提取物具有抗糖尿病的作用,其作用机制与促进胰岛素分泌、调节血脂、抗炎及肝脏保护有关。 展开更多
关键词 毛果鱼藤石油醚提取物 糖尿病 血脂 抗炎作用 肝脏保护
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation
10
作者 Jun He Hao-xue Gao +9 位作者 Na Yang Xiao-dong Zhu Run-bin Sun Yuan Xie Cai-hong Zeng Jing-wei Zhang Jian-kun Wang Fei Ding Ji-ye Aa Guang-ji Wang 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第1期86-97,共12页
Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically.Our pilot experiments and accumulated evidences showed that epalrestat inhibited po... Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically.Our pilot experiments and accumulated evidences showed that epalrestat inhibited polyol pathway and reduced sorbitol production,and suggested the potential renal protection effects of epalrestat on diabetic nephropathy (DN).To evaluate the protective effect of epalrestat,the db/db mice were used and exposed to epalrestat for 8 weeks,both the physiopathological condition and function of kidney were examined.For the first time,we showed that epalrestatmarkedlyreduced albuminuria and alleviated the podocyte foot process fusion and interstitial fibrosis of db/db mice.Metabolomics was employed,and metabolites in the plasma,renal cortex,and urine were profiled using a gas chromatography-mass spectrometry (GC/MS)-based metabolomic platform.We observed an elevation of sorbitol and fructose,and a decrease of myo-inositol in the renal cortex of db/db mice. Epalrestat reversed the renal accumulation of the polyol pathway metabolites of sorbitol and fructose,and increased myo-inositol level.Moreover,the upregulation of aldose reductase,fibronectin,collagen Ⅲ,and TGF-β1 in renal cortex of db/db mice was downregulated by epalrestat.The data suggested that epalrestat has protective effects on DN,and the inhibition ofaldose reductas and the modulation of polyol pathway in nephritic cells be a potentially therapeutic strategy for DN. 展开更多
关键词 diabetes DIABETIC NEPHROPATHY POLYOL pathway metabolomics ALDOSE REDUCTASE
Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis
11
作者 Wan-chun Ye Jian-zhong Ye +3 位作者 Cheng Zheng Xiao-wei He Jia-jie Huang Ren Ye 《中草药:英文版》 CAS 2019年第2期222-230,共9页
Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive resear... Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager(version 5.2) and Stata(version 12.0).Results: A total of 12 randomized controlled trials(RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35,95% CI(1.22, 1.50), P < 0.001], the level of serum albumin [Mean difference(MD)= 3.87, 95% CI(3.12,4.62), P < 0.001], and significantly decreased 24 h urinary protein level [MD =-0.97, 95% CI(-1.19,-0.76), P < 0.001], urinary albumin-excretion rate [MD =-145.53, 95% CI(-227.95,-63.11), P < 0.001],and urinary β2-microglobuli level [MD =-11.86, 95% CI(-13.02,-10.69), P < 0.001]. No significant differences were found in levels of serum creatinine [MD =-0.26, 95% CI(-7.52, 7.00), P > 0.05), blood urea nitrogen [MD = 0.25, 95% CI(-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate[MD =-0.43, 95% CI(-3.48, 2.62), P > 0.05]. However, tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI(1.34, 8.66), P < 0.05].There were no publication bias for all of the pooled effect sizes.Conclusion: Combination therapy of tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed. 展开更多
关键词 DIABETIC NEPHROPATHY META-ANALYSIS TRIPTERYGIUM GLYCOSIDES VALSARTAN
南征教授运用中药治疗消渴气阴两虚挟瘀证的研究
12
作者 张琦 赵芸芸 南征 《吉林中医药》 2019年第3期338-340,350共4页
目的观察南征教授运用中药治疗消渴气阴两虚挟瘀证的疗效。方法选取符合入选标准的消渴患者73例,随机分成观察组43例和对照组30例。对照组给予盐酸二甲双胍片,0.85 g/次,1次/d,随餐口服,观察组给予中药辨证治疗。治疗2个疗程,共8周,分... 目的观察南征教授运用中药治疗消渴气阴两虚挟瘀证的疗效。方法选取符合入选标准的消渴患者73例,随机分成观察组43例和对照组30例。对照组给予盐酸二甲双胍片,0.85 g/次,1次/d,随餐口服,观察组给予中药辨证治疗。治疗2个疗程,共8周,分别观察2组疗效。结果治疗后观察组的总有效率90.6%,对照组的总有效率86.7%,2组空腹血糖(FPG)、餐后血糖(PBG)、糖化血红蛋白(Hb A1c)均下降,且观察组下降幅度更为明显(P <0.05)。结论南征教授运用中药治疗消渴气阴两虚挟瘀证,可使病人达到'阴平阳秘',从根本上治疗消渴病。 展开更多
关键词 消渴 气阴两虚挟瘀证 滋阴清热 益气养阴 活血化瘀
Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway
13
作者 WANG Han-Qing WANG Sha-Sha +2 位作者 Chiufai Kuok WANG Qi CHENG Xiao-Lan 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第5期346-354,共9页
Diabetic nephropathy (DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae (Umb) has been well characterized to exert protective effects in diabete... Diabetic nephropathy (DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae (Umb) has been well characterized to exert protective effects in diabetes. However, the action and mechanism of Umb in DN remains unclear. In this work, we studied the effect of Umb in a streptozotocin (STZ)-induced DN rat model and explore its underlying mechanism. DN rats were treated with Umb (20, 40 mg·kg^-1) or irbesartan (15 mg·kg^-1) for 4 weeks. Levels of serum glucose, insulin, blood uric acid, creatinine, triglycerides (TG) and total cholesterol (TC) were measured by commercial assay kits, respectively. Histopathological changes and inflammatory cytokine levels including IL-6, IL-1β and TNF-α in the kidney were also evaluated. Alterations in the expression of podocin, CD2AP and TLR/NF-κB were assessed by western blotting. Our results showed that Umb reduced renal injury in DN rat model, as evidenced by the decrease in blood glucose, 24 h urinary protein, serum creatinine, and blood uric acid. Umb also significantly ameliorated the renal histopathological alteration, and down-regulated the expression of epithclial-to-mesenchymal transition-related molecular markers podocin and CD2AP. Moreover, Umb inhibited TLR2, TLR4, MyD88 expressions, NF-κB activation and considerably reduced levels of other downstream inflammatory molecules (TNF-α, IL-6, IL-1β). These findings indicated that Umb improved renal function through regulating inflammation and TLR/NF-κB pathway, suggesting the potential efficacy of Umb in DN treatment. 展开更多
关键词 DIABETIC NEPHROPATHY Umbelliferone STREPTOZOTOCIN INFLAMMATION TLR/NF-kB pathway
探析糖尿病合并肺结核患者不同降糖治疗方案与抗结核疗效的关系 预览
14
作者 岳丹 《中国实用医药》 2019年第3期63-64,共2页
目的探析糖尿病合并肺结核患者不同降糖治疗方案与抗结核疗效的关系。方法 74例糖尿病合并肺结核患者,随机分为参照组(给予降糖药物+抗结核治疗)和试验组(给予胰岛素注射+抗结核治疗),各37例。观察比较两组患者治疗前后空腹血糖、餐后2 ... 目的探析糖尿病合并肺结核患者不同降糖治疗方案与抗结核疗效的关系。方法 74例糖尿病合并肺结核患者,随机分为参照组(给予降糖药物+抗结核治疗)和试验组(给予胰岛素注射+抗结核治疗),各37例。观察比较两组患者治疗前后空腹血糖、餐后2 h血糖、病灶吸收效果。结果治疗前,两组患者空腹血糖、餐后2 h血糖水平比较,差异无统计学意义(P>0.05);治疗后,两组患者空腹血糖、餐后2 h血糖水平均低于治疗前,且试验组患者低于参照组,差异具有统计学意义(P<0.05)。试验组患者病灶吸收有效率为86.49%,高于参照组的62.16%,差异具有统计学意义(P<0.05)。结论糖尿病合并肺结核患者实施胰岛素注射+抗结核治疗临床效果更为显著,患者的血糖水平得到改善,病灶吸收率提高,值得临床推荐。 展开更多
关键词 糖尿病 肺结核 降糖治疗方案 抗结核疗效 关系
在线阅读 下载PDF
玻璃体切除联合康柏西普治疗糖尿病视网膜病变
15
作者 范卫华 《中华眼外伤职业眼病杂志》 2019年第5期361-364,共4页
目的评价玻璃体切除术联合康柏西普治疗增生型糖尿病视网膜病变(PDR)的临床效果。方法前瞻性病例对照研究。2016年10月至2017年12月收治的PDR62例(86眼),随机分为两组:单纯玻璃体切除术31例(41眼)为对照组,玻璃体切除术联合康柏西普玻... 目的评价玻璃体切除术联合康柏西普治疗增生型糖尿病视网膜病变(PDR)的临床效果。方法前瞻性病例对照研究。2016年10月至2017年12月收治的PDR62例(86眼),随机分为两组:单纯玻璃体切除术31例(41眼)为对照组,玻璃体切除术联合康柏西普玻璃体内注射31例(45眼)为联合组。术前、术后3个月和6个月检测最佳矫正视力(BCVA)、黄斑视网膜厚度以及黄斑中心区厚度(CMT),并记录并发症情况。结果联合组总有效率优于对照组(95.56%vs75.61%),差异有统计学意义(χ^2=5.5444,P=0.0185)。联合组术前、术后3个月和6个月BCVA(LogMAR)分别为1.13±0.19、0.71±0.22、0.38±0.16;而对照组分别为1.12±0.18、0.73±0.20、0.53±0.18。联合组术后6个月BCVA优于对照组,差异有统计学意义(t=4.0910,P=0.0001)。两组手术前后CMT、黄斑视网膜厚度及术后并发症发生率差异均无统计学意义(P>0.05)。结论采用玻璃体切除术联合康柏西普治疗PDR具有良好的临床效果。 展开更多
关键词 视网膜病变 糖尿病性 增生性 玻璃体切除术 康柏西普 视功能 黄斑中心区厚度
电针对糖尿病大鼠造影剂肾损伤的保护作用 预览
16
作者 祁建丽 赵凯 高巧营 《中国中医急症》 2019年第7期1152-1155,1179共5页
目的观察电针对造影剂肾病模型(CIN模型)大鼠肾损伤的影响。方法选取雄性清洁级SD大鼠50只,随机选取10只大鼠为对照组,将剩余40只制备成糖尿病模型,造模成功30只,随机分为模型组,电针组,冬虫夏草组,各10只,糖尿病模型建好后饲养9周,对... 目的观察电针对造影剂肾病模型(CIN模型)大鼠肾损伤的影响。方法选取雄性清洁级SD大鼠50只,随机选取10只大鼠为对照组,将剩余40只制备成糖尿病模型,造模成功30只,随机分为模型组,电针组,冬虫夏草组,各10只,糖尿病模型建好后饲养9周,对照组与模型组给予等量0.9%氯化钠注射液灌胃,电针组给予电针治疗,冬虫夏草组给予冬虫夏草菌粉[3 g/(kg·d)]灌胃,各组干预1周后建立糖尿病CIN模型,处死大鼠,摘取左肾,以备肾脏病理研究,摘取右肾,用于Western blotting定量分析,观察各组大鼠的尿素氮(BUN)、血肌酐(SCr)、氧化应激指标及肾组织Caspase-3、Caspase-9蛋白检测水平,并采用HE染色和TUNEL染色观察各组肾脏组织的病理改变。结果1)与模型组比较,冬虫夏草组、电针组的大鼠的BUN、Scr、Kim-l、NGAL均明显下降(P<0.05)。2)与模型组比较,冬虫夏草组、电针组氧化应激指标均降低,以及Caspase-9、Caspase-3表达水平均升高(P<0.05)。3)其中冬虫夏草组、电针组差异无统计学意义(P>0.05)。结论电针能够减轻糖尿病大鼠CIN的早期肾损害,且与冬虫夏草治疗效果相当。 展开更多
关键词 造影剂肾病 糖尿病 电针 冬虫夏草 大鼠 肾功能
在线阅读 下载PDF
Effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy
17
作者 Jun Li Xiao-Hong Zhang 《海南医科大学学报(英文版)》 2019年第3期31-35,共5页
Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy trea... Objective: To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy. Methods: The patients with early diabetic nephropathy treated in our hospital between February 2015 and April 2017 were chosen and divided into two groups by random number table, observation group received Qishen Yiqi Drop Pill combined with conventional therapy and control group accepted conventional therapy. The renal function indexes, cytokine contents and oxygen free radical generation were compared before treatment and 3 months after treatment. Results:Urine UREA levels as well as serum β2 microglobulin (β2-MG), cystatin C (CysC), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), stromal cell-derived factor-1 (SDF-1), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) contents of both groups were significantly lower while superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) contents were significantly higher after treatment, and urine UREA level as well as serum β2-MG, CysC, TNF-α, IL-6, SDF-1, IL-17, TGF-β1, MDA and 8-iso-PGF2α contents of observation group after treatment was significantly lower than those of control group while SOD and T-AOC contents were significantly higher than those of control group. Conclusion: Adjuvant Qishen Yiqi Drop Pill therapy can improve the renal function and reduce the inflammatory response and oxidative stress response in early diabetic nephropathy. 展开更多
关键词 DIABETIC NEPHROPATHY Qishen Yiqi DROP PILL Renal function Inflammatory RESPONSE Oxidative stress RESPONSE
Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members 预览
18
作者 Maureen M Leonard Stephanie Camhi +4 位作者 Victoria Kenyon Rebecca A Betensky Craig Sturgeon Shu Yan Alessio Fasano 《世界糖尿病杂志:英文版(电子版)》 2019年第3期189-199,共11页
BACKGROUND Patients with type 1 diabetes (T1D) and their first-degree relatives (FDRs) have an increased risk of developing celiac disease (CD) compared to the general population. This is largely explained by the shar... BACKGROUND Patients with type 1 diabetes (T1D) and their first-degree relatives (FDRs) have an increased risk of developing celiac disease (CD) compared to the general population. This is largely explained by the shared association with major histocompatibility class II human leukocyte antigen (HLA) DQ2 and/or DQ8 between the two disease states. AIM To describe the frequency of CD autoimmunity (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D and their FDRs. Additionally, we aimed at identifying predictors associated with an increased risk of developing CDA in patients with T1D and their family members. METHODS We obtained clinical information and blood samples from 1027 participants (302 with T1D and 725 FDRs) over a five-year period. Samples were tested for autoantibodies associated with CD, HLA-DQ alleles, and haptoglobin genotype.We fit univariate and multiple logistic regression models for CDA separately for subjects with T1D and for FDRs of subjects with T1D. RESULTS Implementation of a screening program increased the frequency of CDA by 2- fold in participants with T1D and 2.8-fold in their FDRs. Multivariate analysis found that, in participants with T1D, having both DR7-DQ2 and DR4-DQ8 was associated with an increased frequency of CDA. In FDRs of T1D patients, reported CD in the family was associated with an increased frequency of CDA during screening. Haptoglobin 2 genotype was not associated with developing CDA in the multivariate analysis. CONCLUSION Patients with T1D and their FDRs have a high frequency of CDA. Carrying both DR7-DQ2 and DR4-DQ8 was associated with development of CDA in patients with T1D. 展开更多
关键词 Screening GLUTEN Diabetic COELIAC HAPTOGLOBIN Human LEUKOCYTE antigen
在线阅读 免费下载
Burden of diabetic foot ulcer in Nigeria: Current evidence from the multicenter evaluation of diabetic foot ulcer in Nigeria 预览
19
作者 Ejiofor Ugwu Olufunmilayo Adeleye +3 位作者 Ibrahim Gezawa Innocent Okpe Marcelina Enamino Ignatius Ezeani 《世界糖尿病杂志:英文版(电子版)》 2019年第3期200-211,共12页
BACKGROUND Nigeria bears the greatest burden of diabetes prevalence in Sub-Saharan Africa. Diabetic foot ulcer (DFU) is a serious and potentially life-threatening complication of diabetes. Significant improvements in ... BACKGROUND Nigeria bears the greatest burden of diabetes prevalence in Sub-Saharan Africa. Diabetic foot ulcer (DFU) is a serious and potentially life-threatening complication of diabetes. Significant improvements in diabetic foot incidence and outcomes have been recorded in many Western countries in the past decade. However, the current burden of DFU in Nigeria is largely unknown. AIM To evaluate the patients’ profile, ulcer characteristics, associated co-morbidities and outcome of patients with DFU in Nigeria. METHODS Multicenter evaluation of diabetic foot ulcer in Nigeria was a one year multicenter observational study of patients hospitalized for DFU in six tertiary health institutions in Nigeria from March 2016 to March 2017. Demographic and diabetes information, ulcer characteristics and associated co-morbidities were assessed. Relevant laboratory and imaging studies were performed. All patients received appropriate multi-disciplinary care and were followed up until discharge or death. Outcome variables of interest were ulcer healing, lower extremity amputation (LEA), duration of hospitalization and mortality. RESULTS A total of 336 patients (55.1% male) with mean age of 55.9 ± 12.5 years were enrolled into this study. Majority (96.1%) had type 2 diabetes. Only 25.9% of the subjects had prior foot care knowledge. Most of the subjects presented late to the hospital and median (IQR) duration of ulcer at presentation was 39 (28-54) d. Ulcers were already advanced (Wagner grades ≥ 3) in 79.2% of the subjects while 76.8% of the ulcers were infected at the time of admission. The commonest comorbidities were systemic hypertension, anemia and hyperglycemic emergencies. One hundred and nineteen subjects (35.4%) suffered LEA while 10.4% left against medical advice. The median (IQR) duration of hospitalization was 52.0 (29-66) d with case fatality rate of 20.5%. CONCLUSION The burden of DFU in Nigeria is very high. The major gaps include low level of foot care knowledge among diabetic patients, overdependence on 展开更多
关键词 BURDEN Diabetes Epidemiology FOOT ULCER Amputation Mortality MULTICENTER EVALUATION of diabetic FOOT ULCER in NIGERIA NIGERIA Africa
在线阅读 免费下载
Risk factors for endophthalmitis after cataract surgery in diabetic patients: a case control study
20
作者 Sukhum Silpa-archa Apichaya Papirachnart +1 位作者 Panisa Singhanetr Janine M Preble 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期417-423,共7页
AIM: To identify risk factors associated with post-cataract surgery endophthalmitis(PCE) in type 2 diabetic patients.METHODS: A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic pati... AIM: To identify risk factors associated with post-cataract surgery endophthalmitis(PCE) in type 2 diabetic patients.METHODS: A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic patients undergoing cataract surgery in Rajavithi Hospital from January 2007 to December 2015. Fifteen patients with PCE were included as the case group and 179 patients without PCE were included as the control group. Potential factors associated with PCE among both groups including demographics, pre-operative characteristics, surgical settings and complications, were statistically analyzed using Chi-square testing and a logistic regression model.RESULTS: Within the case group, 53% were females and the median age was 68 y. Univariate analysis of pre-operative characteristics, surgical settings and complications revealed that recent pre-operative fasting plasma glucose, insulin therapy, presence of diabetic retinopathy, and severe non-proliferative or proliferative diabetic retinopathy were significantly associated with PCE. In a multivariate analysis adjusting for blood glucose level, insulin treatment was the only significant factor associated with an increased risk of PCE(OR 3.9, 95%CI 1.0-15.0, P=0.04) compared to patients without insulin treatment. The most common causative organisms were gram-positive bacteria(89%). Staphylococcus species represented the most common group(67%). Median best corrected visual acuity at 1-month and 3-month follow-up was equal at 0.7 logMAR(20/100).CONCLUSION: The authors identify insulin treatment as the only risk factor associated with endophthalmitis after cataract surgery in type 2 diabetic patients. Further studies with serum levels of pre-operative glycated hemoglobin(HbA1c) and post-operative fasting plasma glucose level are essential to truly demonstrate the role of peri-operative glycemic markers as a risk factor for PCE. 展开更多
关键词 ENDOPHTHALMITIS CATARACT SURGERY DIABETIC patients insulin FASTING plasma GLUCOSE
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈